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Conserved domains on  [gi|503427328|ref|WP_013661989|]
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ABC transporter permease [Marinomonas mediterranea]

Protein Classification

ABC transporter permease( domain architecture ID 11439449)

ABC transporter permease is the transmembrane (TM) subunit in a periplasmic binding protein (PBP)-dependent ATP-binding cassette (ABC) transporter which generally binds a type 2 PBP; similar to the permease subunit of ABC-type dipeptide/oligopeptide/nickel transport systems

Gene Ontology:  GO:0140359|GO:0042626
PubMed:  25750732|24638992
TCDB:  3.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DppC COG1173
ABC-type dipeptide/oligopeptide/nickel transport system, permease component [Amino acid ...
 15-307 1.63e-93

ABC-type dipeptide/oligopeptide/nickel transport system, permease component [Amino acid transport and metabolism, Inorganic ion transport and metabolism];


:

Pssm-ID: 440786 [Multi-domain]  Cd Length: 275  Bit Score: 278.53  E-value: 1.63e-93
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503427328  15 ANRLHHIWAGVVGDKLAIMACAAFIFYCVVSVLAPLIAPYDindPNFMDLLNAEIAPYWvsgdeRFLLGTDSQGRDLLSV 94
Cdd:COG1173    2 RSRWRRAWRRLRRNPLAVIGLVILLLLVLLALFAPLLAPYD---PTAQDLAARLQPPSA-----AHWLGTDQLGRDVLSR 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503427328  95 ILYGTRLSLTIGILAVAIQAFIGISIGLISGYVGGRVDSFLMRFADVQLSFSTIMTAIVFLAIFQATfgvdtyedlaMLM 174
Cdd:COG1173   74 LLYGARISLLVGLLAVLIALVIGVLLGLLAGYFGGWVDAVLMRLVDVLLAFPSLLLAIALVAVLGPG----------LLN 143

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503427328 175 LILVIGLAEWPLFARTIRASVLAEKQKEYIDAARVMGIGKTRIMFRHILPNTLTPVLVIFTIQIANAIIAEAALSFLGLG 254
Cdd:COG1173  144 VILALGLTGWPGYARLVRAQVLSLREREYVEAARALGASPLRIIFRHILPNVLPPLIVQATLGIASAILAEAGLSFLGLG 223

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 503427328 255 MPSTEPSLGALISSGFRYLFSgAWWICVIPSVALIGLILVMNLLGDWLRDYLN 307
Cdd:COG1173  224 VQPPTPSWGTMLSEGRNYLLT-APWLALFPGLAIVLTVLAFNLLGDGLRDALD 275
 
Name Accession Description Interval E-value
DppC COG1173
ABC-type dipeptide/oligopeptide/nickel transport system, permease component [Amino acid ...
 15-307 1.63e-93

ABC-type dipeptide/oligopeptide/nickel transport system, permease component [Amino acid transport and metabolism, Inorganic ion transport and metabolism];


Pssm-ID: 440786 [Multi-domain]  Cd Length: 275  Bit Score: 278.53  E-value: 1.63e-93
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503427328  15 ANRLHHIWAGVVGDKLAIMACAAFIFYCVVSVLAPLIAPYDindPNFMDLLNAEIAPYWvsgdeRFLLGTDSQGRDLLSV 94
Cdd:COG1173    2 RSRWRRAWRRLRRNPLAVIGLVILLLLVLLALFAPLLAPYD---PTAQDLAARLQPPSA-----AHWLGTDQLGRDVLSR 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503427328  95 ILYGTRLSLTIGILAVAIQAFIGISIGLISGYVGGRVDSFLMRFADVQLSFSTIMTAIVFLAIFQATfgvdtyedlaMLM 174
Cdd:COG1173   74 LLYGARISLLVGLLAVLIALVIGVLLGLLAGYFGGWVDAVLMRLVDVLLAFPSLLLAIALVAVLGPG----------LLN 143

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503427328 175 LILVIGLAEWPLFARTIRASVLAEKQKEYIDAARVMGIGKTRIMFRHILPNTLTPVLVIFTIQIANAIIAEAALSFLGLG 254
Cdd:COG1173  144 VILALGLTGWPGYARLVRAQVLSLREREYVEAARALGASPLRIIFRHILPNVLPPLIVQATLGIASAILAEAGLSFLGLG 223

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 503427328 255 MPSTEPSLGALISSGFRYLFSgAWWICVIPSVALIGLILVMNLLGDWLRDYLN 307
Cdd:COG1173  224 VQPPTPSWGTMLSEGRNYLLT-APWLALFPGLAIVLTVLAFNLLGDGLRDALD 275
PRK10913 PRK10913
dipeptide ABC transporter permease DppC;
18-309 3.46e-49

dipeptide ABC transporter permease DppC;


Pssm-ID: 182833 [Multi-domain]  Cd Length: 300  Bit Score: 165.73  E-value: 3.46e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503427328  18 LHHIWAGVVGDKLAIMACAAFIFYCVVSVLAPLIAPYDINDpNFMDLLNAeiAPYWVSGDE-RFLLGTDSQGRDLLSVIL 96
Cdd:PRK10913  19 LQEFWHYFKRNKGAVVGLVYVVIMLFIAIFANWIAPHNPAE-QFRDALLA--PPVWQEGGSwAHILGTDDVGRDVLSRLM 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503427328  97 YGTRLSLTIGILAVAIQAFIGISIGLISGYVGGRVDSFLMRFADVQLSFSTIMTAIVFLAIFQATFGVdtyedlAMLMLI 176
Cdd:PRK10913  96 YGARLSLLVGCLVVVLSLVMGVILGLIAGYFGGLVDNIIMRVVDIMLALPSLLLALVLVAIFGPSIVN------AALALT 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503427328 177 LViglaEWPLFARTIRASVLAEKQKEYIDAARVMGIGKTRIMFRHILPNTLTPVLVIFTIQIANAIIAEAALSFLGLGMP 256
Cdd:PRK10913 170 FV----ALPHYVRLTRAAVLVEVNRDYVTASRVAGAGAMRQMFINILPNCLAPLIVQASLGFSNAILDMAALGFLGMGAQ 245

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 503427328 257 STEPSLGALISSGFRYLFSgAWWICVIPSVALIGLILVMNLLGDWLRDYLNPR 309
Cdd:PRK10913 246 PPTPEWGTMLSDVLQFAQS-AWWVVTFPGLAILLTVLAFNLMGDGLRDALDPK 297
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 100-291 2.91e-17

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 78.09  E-value: 2.91e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503427328 100 RLSLTIGILAVAIQAFIGISIGLISGYVGGRVDSFLMRFADVQLSFSTIMTAIVFLAIFQATFGVDTYEDLAMLMLILVI 179
Cdd:cd06261    2 LNTLLLALIATLLALVLGLLLGIILARKRGKLDRLLRRIIDLLLSLPSLVLGLLLVLLFGVLLGWGILPGLGLPALILAL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503427328 180 GLaeWPLFARTIRASVLAEKQKEYIDAARVMGIGKTRIMFRHILPNTLTPVLVIFTIQIANAIIAEAALSFLGLGMPSTe 259
Cdd:cd06261   82 LL--IAPFARLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFALVSFLGGGEAPG- 158

                        170       180       190
                 ....*....|....*....|....*....|..
gi 503427328 260 PSLGALISSGFRYLFSGAWWICVIPSVALIGL 291
Cdd:cd06261  159 PGTGLLLIFAILFPGDLGVAAAVALILLLLSL 190
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 117-310 2.97e-13

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 66.94  E-value: 2.97e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503427328  117 GISIGLISG-YVGGRVDSFLMRFADVQLSFSTIMTAIVFLAIFQatFGVDTYEDLAMLMLILVIglaeWPLFARTIRASV 195
Cdd:pfam00528   1 GIPLGIIAAlRRGRRLDRLLRPLIDLLQALPSFVLAILLVVIAI--LSILGHGILPAIILALLG----WAGYARLIRRAA 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503427328  196 LAEKQKEYIDAARVMGIGKTRIMFRHILPNTLTPVLVIFTIQIANAIIAEAALSFLGLGmpstePSLGALISSGFRYLFS 275
Cdd:pfam00528  75 LRSLPSDLVEAARALGASRWQIFRKIILPNALPPILTGLALAFGGALGGAVLLEFLGSW-----PGLGLLLIEAILGYDY 149

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 503427328  276 GAWWicvIPSVALIGLILVMNLLGDWLRDYLNPRT 310
Cdd:pfam00528 150 PEIQ---GPVLAAALILLLLNLLVDILQRLLDPRV 181
 
Name Accession Description Interval E-value
DppC COG1173
ABC-type dipeptide/oligopeptide/nickel transport system, permease component [Amino acid ...
 15-307 1.63e-93

ABC-type dipeptide/oligopeptide/nickel transport system, permease component [Amino acid transport and metabolism, Inorganic ion transport and metabolism];


Pssm-ID: 440786 [Multi-domain]  Cd Length: 275  Bit Score: 278.53  E-value: 1.63e-93
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503427328  15 ANRLHHIWAGVVGDKLAIMACAAFIFYCVVSVLAPLIAPYDindPNFMDLLNAEIAPYWvsgdeRFLLGTDSQGRDLLSV 94
Cdd:COG1173    2 RSRWRRAWRRLRRNPLAVIGLVILLLLVLLALFAPLLAPYD---PTAQDLAARLQPPSA-----AHWLGTDQLGRDVLSR 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503427328  95 ILYGTRLSLTIGILAVAIQAFIGISIGLISGYVGGRVDSFLMRFADVQLSFSTIMTAIVFLAIFQATfgvdtyedlaMLM 174
Cdd:COG1173   74 LLYGARISLLVGLLAVLIALVIGVLLGLLAGYFGGWVDAVLMRLVDVLLAFPSLLLAIALVAVLGPG----------LLN 143

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503427328 175 LILVIGLAEWPLFARTIRASVLAEKQKEYIDAARVMGIGKTRIMFRHILPNTLTPVLVIFTIQIANAIIAEAALSFLGLG 254
Cdd:COG1173  144 VILALGLTGWPGYARLVRAQVLSLREREYVEAARALGASPLRIIFRHILPNVLPPLIVQATLGIASAILAEAGLSFLGLG 223

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 503427328 255 MPSTEPSLGALISSGFRYLFSgAWWICVIPSVALIGLILVMNLLGDWLRDYLN 307
Cdd:COG1173  224 VQPPTPSWGTMLSEGRNYLLT-APWLALFPGLAIVLTVLAFNLLGDGLRDALD 275
PRK10913 PRK10913
dipeptide ABC transporter permease DppC;
18-309 3.46e-49

dipeptide ABC transporter permease DppC;


Pssm-ID: 182833 [Multi-domain]  Cd Length: 300  Bit Score: 165.73  E-value: 3.46e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503427328  18 LHHIWAGVVGDKLAIMACAAFIFYCVVSVLAPLIAPYDINDpNFMDLLNAeiAPYWVSGDE-RFLLGTDSQGRDLLSVIL 96
Cdd:PRK10913  19 LQEFWHYFKRNKGAVVGLVYVVIMLFIAIFANWIAPHNPAE-QFRDALLA--PPVWQEGGSwAHILGTDDVGRDVLSRLM 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503427328  97 YGTRLSLTIGILAVAIQAFIGISIGLISGYVGGRVDSFLMRFADVQLSFSTIMTAIVFLAIFQATFGVdtyedlAMLMLI 176
Cdd:PRK10913  96 YGARLSLLVGCLVVVLSLVMGVILGLIAGYFGGLVDNIIMRVVDIMLALPSLLLALVLVAIFGPSIVN------AALALT 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503427328 177 LViglaEWPLFARTIRASVLAEKQKEYIDAARVMGIGKTRIMFRHILPNTLTPVLVIFTIQIANAIIAEAALSFLGLGMP 256
Cdd:PRK10913 170 FV----ALPHYVRLTRAAVLVEVNRDYVTASRVAGAGAMRQMFINILPNCLAPLIVQASLGFSNAILDMAALGFLGMGAQ 245

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 503427328 257 STEPSLGALISSGFRYLFSgAWWICVIPSVALIGLILVMNLLGDWLRDYLNPR 309
Cdd:PRK10913 246 PPTPEWGTMLSDVLQFAQS-AWWVVTFPGLAILLTVLAFNLMGDGLRDALDPK 297
SapC COG4171
ABC-type antimicrobial peptide export system, permease component SapC [Defense mechanisms];
8-311 1.85e-48

ABC-type antimicrobial peptide export system, permease component SapC [Defense mechanisms];


Pssm-ID: 443331 [Multi-domain]  Cd Length: 296  Bit Score: 163.83  E-value: 1.85e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503427328   8 EYSHLSHANRLHHIWAGVVGDKLAIMACAAFIFYCVVSVLAPLIAPYDINDPNFMDLLnaeIAPYWV-SGDERFLLGTDS 86
Cdd:COG4171    6 IYEEERIPSPLKQIWQSFRKNPLAMIGLYGFLFLILLALFGPLLAPYSPDQQFIGALL---LPPSWDdNGDVSFFLGTDD 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503427328  87 QGRDLLSVILYGTRLSLTIGILAVAIQAFIGISIGLISGYVGGRVDSFLMRFADVQLSFSTIMTAIVFLAIFQAtfgvdt 166
Cdd:COG4171   83 LGRDILSRLLYGARYTFGSALLVVLAAAIIGGIIGILAGMSRGLKSSILNHLLDTLLSIPSLLLAIIIVALLGP------ 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503427328 167 yeDLAMLMLIlvIGLAEWPLFARTIRASVLAEKQKEYIDAARVMGIGKTRIMFRHILPNTLTPVLVIFTIQIANAIIAEA 246
Cdd:COG4171  157 --GLENAMLA--ITLALLPQFIHAIYQAVHQELKKEYVLAARLDGASNWQLLRYSILPNILEVLVTELTRALSIAILDIS 232

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 503427328 247 ALSFLGLGMPSTEPSLGALISSGFRYLFSgAWWICVIPSVALIGLILVMNLLGDWLRDYLNPRTY 311
Cdd:COG4171  233 ALGFLGLGAQLPSPEWGAMLGDSLELIYL-APWTVILPGLAIMFSVLIVNLVGDGLRRALNKGVE 296
PRK15082 PRK15082
glutathione ABC transporter permease GsiD; Provisional
 29-309 5.44e-48

glutathione ABC transporter permease GsiD; Provisional


Pssm-ID: 185040 [Multi-domain]  Cd Length: 301  Bit Score: 162.59  E-value: 5.44e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503427328  29 KLAIMACAAFIFYCVVSVLAPLIAPYDINDPNFMDLLNAeiAPYWVSgderfLLGTDSQGRDLLSVILYGTRLSLTIGIL 108
Cdd:PRK15082  36 HVALVAGLFVLLLIVVAIFAPWIAPYDAENYFDYDALNA--GPSLQH-----WFGVDSLGRDIFSRILVGARISLAAGFF 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503427328 109 AVAIQAFIGISIGLISGYVGGRVDSFLMRFADVQLSFSTIMTAIVFLAIFQAtfgvdtyedlAMLMLILVIGLAEWPLFA 188
Cdd:PRK15082 109 SVAIGAAIGTVLGLLAGYYEGWWDRIIMRICDVLFAFPGILLAIAVVAILGS----------GMANVIIAVAIFSIPAFA 178

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503427328 189 RTIRASVLAEKQKEYIDAARVMGIGKTRIMFRHILPNTLTPVLVIFTIQIANAIIAEAALSFLGLGMPSTEPSLGALISS 268
Cdd:PRK15082 179 RLVRGNTLVLKQQTYIESARSIGASDWTILLRHILPGTVSSIVVYFTMRIGTSIITAASLSFLGLGAQPPTPEWGAMLNE 258

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 503427328 269 GfRYLFSGAWWICVIPSVALIGLILVMNLLGDWLRDYLNPR 309
Cdd:PRK15082 259 A-RADMVIAPHVALFPSLAIFLTVLAFNLLGDGLRDALDPK 298
YejE COG4239
ABC-type microcin C transport system, permease component YejE [Secondary metabolites ...
 46-309 1.20e-46

ABC-type microcin C transport system, permease component YejE [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 443381 [Multi-domain]  Cd Length: 342  Bit Score: 160.32  E-value: 1.20e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503427328  46 VLAPLIaPYDINDPNFMDLLNAEIAPywvsgDERFLLGTDSQGRDLLSVILYGTRLSLTIGILAVAIQAFIGISIGLISG 125
Cdd:COG4239   93 ALWPPI-PYSYDTINYDLPSPAPSPP-----SAENWLGTDDQGRDVLARLIYGFRISVLFGLALTVISSVIGVAAGAVQG 166

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503427328 126 YVGGRVDSFLMRFADVQLSFSTIMTAIVFLAIFQATFGVdtyedlamlmLILVIGLAEWPLFARTIRASVLAEKQKEYID 205
Cdd:COG4239  167 YFGGRVDLLFQRFIEIWSSMPELYLLIILSSIFQPSFWL----------LLGILLLFGWMGLVGVVRAEFLRARNLEYVR 236

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503427328 206 AARVMGIGKTRIMFRHILPNTLTPVLVIFTIQIANAIIAEAALSFLGLGMPSTEPSLGALISSGFRYLfsGAWWICVIPS 285
Cdd:COG4239  237 AARALGVSDRRIMFRHILPNAMVATLTFLPFILSGAITTLTSLDFLGFGLPPGSPSLGELLAQGKNNL--QAPWLGLSAF 314

                        250       260
                 ....*....|....*....|....
gi 503427328 286 VALIGLILVMNLLGDWLRDYLNPR 309
Cdd:COG4239  315 VVLALMLSLLVFIGEAVRDAFDPR 338
nikC PRK10417
nickel transporter permease NikC; Provisional
 32-308 2.92e-46

nickel transporter permease NikC; Provisional


Pssm-ID: 236687 [Multi-domain]  Cd Length: 272  Bit Score: 157.52  E-value: 2.92e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503427328  32 IMACAAFIFYCVVSVLAPLIAPYDindPNFMDLLNAEIAPywvsgDERFLLGTDSQGRDLLSVILYGTRLSLTIGILAVA 111
Cdd:PRK10417   7 RLALIIIALLALIALTSQWWLPYD---PQAIDLPSRLLSP-----DAQHWLGTDHLGRDIFSRLMAGTRVSLGSVMACLL 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503427328 112 IQAFIGISIGLISGYVGGRVDSFLMRFADVQLSFSTIMTAIVFLAIFQAtfgvdtyedlAMLMLILVIGLAEWPLFARTI 191
Cdd:PRK10417  79 LVLALGLVIGGSAGLLGGRVDQATMRVADMFMTFPTSILAFFMVGVLGT----------GLTNVIIAIALSHWAWYARMV 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503427328 192 RASVLAEKQKEYIDAARVMGIGKTRIMFRHILPNTLTPVLVIFTIQIANAIIAEAALSFLGLGMPSTEPSLGALISSGFR 271
Cdd:PRK10417 149 RSLVISLRQREFVLAARLSGAGHVRVFIDHLLPAVIPQLLVLATLDIGHMMLHVAGLSFLGLGVTAPTAEWGVMINDARQ 228

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 503427328 272 YLFSGAWWIcVIPSVALIGLILVMNLLGDWLRDYLNP 308
Cdd:PRK10417 229 YIWTQPLLM-FWPGLALFISVMAFNLLGDALRDHLDP 264
PRK09881 PRK09881
D,D-dipeptide ABC transporter permease;
16-310 2.51e-39

D,D-dipeptide ABC transporter permease;


Pssm-ID: 182131 [Multi-domain]  Cd Length: 296  Bit Score: 139.95  E-value: 2.51e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503427328  16 NRLHHIWAgVVGDKLAIMACAAFIFYCVVSVLAPLIAPYDINDPNFMDLLNAEIAPYWvsgderflLGTDSQGRDLLSVI 95
Cdd:PRK09881  19 NGAKLVWM-LKGSPLTVTGAVIIVLMLLMMIFSPWLATHDPNAIDLTARLLPPSAAHW--------FGTDEVGRDLFSRV 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503427328  96 LYGTRLSLTIGILAVAIQAFIGISIGLISGYVGGRVDSFLMRFADVQLSfstiMTAIVFLAIFQATFGVDTYEdlAMLML 175
Cdd:PRK09881  90 LVGSQQSILAGLVVVAIAGMIGSLLGCLSGVLGGRADAIIMRIMDIMLS----IPSLVLTMALAAALGPSLFN--AMLAI 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503427328 176 ILViglaEWPLFARTIRASVLAEKQKEYIDAARVMGIGKTRIMFRHILPNTLTPVLVIFTIQIANAIIAEAALSFLGLGM 255
Cdd:PRK09881 164 AIV----RIPFYVRLARGQALVVRQYTYVQAAKTFGASRWHLISWHILRNSLPPLIVQASLDIGSAILMAATLGFIGLGA 239

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 503427328 256 PSTEPSLGALISSGFRYLFSgAWWICVIPSVALIGLILVMNLLGDWLRDYLNPRT 310
Cdd:PRK09881 240 QQPSAEWGAMVANGRNYVLD-QWWYCAFPGAAILLTAVGFNLFGDGIRDLLDPKA 293
PRK15406 PRK15406
oligopeptide ABC transporter permease OppC; Provisional
 46-309 4.52e-36

oligopeptide ABC transporter permease OppC; Provisional


Pssm-ID: 185304 [Multi-domain]  Cd Length: 302  Bit Score: 131.50  E-value: 4.52e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503427328  46 VLAPLIAPYDINDpnfMDLLNAEIAPYWVSGDerfLLGTDSQGRDLLSVILYGTRLSLTIGILAVAIQAFIGISIGLISG 125
Cdd:PRK15406  54 ILAPMLSQFAYDD---TDWGMMSSAPDMESGH---YFGTDSSGRDLLVRVAIGGRISLMVGVAAALVAVVVGTLYGSLSG 127

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503427328 126 YVGGRVDSFLMRFADVQLSFSTIMTAIVFLAIFQATfgvdtyedlaMLMLILVIGLAEWPLFARTIRASVLAEKQKEYID 205
Cdd:PRK15406 128 YLGGKVDSVMMRLLEILNSFPFMFFVILLVTFFGQN----------ILLIFVAIGMVSWLDMARIVRGQTLSLKRKEFIE 197

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503427328 206 AARVMGIGKTRIMFRHILPNTLTPVLVIFTIQIANAIIAEAALSFLGLGMPSTEPSLGALISSGFRYLfSGAWWICVIPS 285
Cdd:PRK15406 198 AAQVGGVSTRGIVLRHIVPNVLGVVVVYASLLVPSMILFESFLSFLGLGTQEPLSSWGALLSDGANSM-EVSPWLLLFPA 276

                        250       260
                 ....*....|....*....|....
gi 503427328 286 VALIGLILVMNLLGDWLRDYLNPR 309
Cdd:PRK15406 277 GFLVVTLFCFNFIGDGLRDALDPK 300
PRK15021 PRK15021
microcin C ABC transporter permease; Provisional
 82-308 3.59e-30

microcin C ABC transporter permease; Provisional


Pssm-ID: 184982 [Multi-domain]  Cd Length: 341  Bit Score: 116.62  E-value: 3.59e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503427328  82 LGTDSQGRDLLSVILYGTRLSLTIGILAVAIQAFIGISIGLISGYVGGRVDSFLMRFADVQLSFSTIMTAIVFLAIFQAT 161
Cdd:PRK15021 123 LGTDANGGDVLARILYGTRISVLFGLMLTLCSSVMGVLAGALQGYYGGKVDLWGQRFIEVWSGMPTLFLIILLSSVVQPN 202

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503427328 162 FgvdtyedLAMLMLILVIGlaeWPLFARTIRASVLAEKQKEYIDAARVMGIGKTRIMFRHILPNTLTPVLVIFTIQIANA 241
Cdd:PRK15021 203 F-------WWLLAITVLFG---WMSLVGVVRAEFLRTRNFDYIRAAQALGVSDRSIILRHMLPNAMVATLTFLPFILCSS 272

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 503427328 242 IIAEAALSFLGLGMPSTEPSLGALISSGFRYLFSGAWWICVIPSVALIGLILVmnLLGDWLRDYLNP 308
Cdd:PRK15021 273 ITTLTSLDFLGFGLPLGSPSLGELLLQGKNNLQAPWLGITAFLSVAILLSLLI--FIGEAVRDAFDP 337
PRK15111 PRK15111
peptide ABC transporter permease SapC;
17-307 9.22e-26

peptide ABC transporter permease SapC;


Pssm-ID: 185066 [Multi-domain]  Cd Length: 296  Bit Score: 104.01  E-value: 9.22e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503427328  17 RLHHIWAGVVGDKLAIMACAAFIFYCVVSVLAPLIAPYDInDPNFMDLlnAEIAPYWVS-GDERFLLGTDSQGRDLLSVI 95
Cdd:PRK15111  15 TLRTAWRKFYSDALAMVGLYGCAGLALLCLFGGWLAPYGI-DQQFLGY--QLLPPSWSRyGEVSFFLGTDDLGRDVLSRL 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503427328  96 LYGTRLSLTIGILAVAIQAFIGISIGLISGYVGGRVDSFLMRFADVQLSFSTIMTAIVFLAIFQATFgvdtyeDLAMLml 175
Cdd:PRK15111  92 LSGAAPTVGGAFVVTLAATLCGLVLGVFAGATHGLRSAVLNHILDTLLSIPSLLLAIIVVAFAGPSL------SHAMF-- 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503427328 176 ilVIGLAEWPLFARTIRASVLAEKQKEYIDAARVMGIGKTRIMFRHILPNTLTPVLVIFTIQIANAIIAEAALSFLGLGM 255
Cdd:PRK15111 164 --AVWLALLPRMVRSIYSAVHDELEKEYVIAARLDGASTLNILWYAVLPNITAGLVTEITRALSMAILDIAALGFLDLGA 241

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 503427328 256 PSTEPSLGALISSGFRYLFSgAWWICVIPSVALIGLILVMNLLGDWLRDYLN 307
Cdd:PRK15111 242 QLPSPEWGAMLGDSLELIYV-APWTVMLPGAAIMLSVLLVNLLGDGIRRAII 292
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 100-291 2.91e-17

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 78.09  E-value: 2.91e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503427328 100 RLSLTIGILAVAIQAFIGISIGLISGYVGGRVDSFLMRFADVQLSFSTIMTAIVFLAIFQATFGVDTYEDLAMLMLILVI 179
Cdd:cd06261    2 LNTLLLALIATLLALVLGLLLGIILARKRGKLDRLLRRIIDLLLSLPSLVLGLLLVLLFGVLLGWGILPGLGLPALILAL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503427328 180 GLaeWPLFARTIRASVLAEKQKEYIDAARVMGIGKTRIMFRHILPNTLTPVLVIFTIQIANAIIAEAALSFLGLGMPSTe 259
Cdd:cd06261   82 LL--IAPFARLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFALVSFLGGGEAPG- 158

                        170       180       190
                 ....*....|....*....|....*....|..
gi 503427328 260 PSLGALISSGFRYLFSGAWWICVIPSVALIGL 291
Cdd:cd06261  159 PGTGLLLIFAILFPGDLGVAAAVALILLLLSL 190
DppB COG0601
ABC-type dipeptide/oligopeptide/nickel transport system, permease component [Amino acid ...
 86-234 8.89e-17

ABC-type dipeptide/oligopeptide/nickel transport system, permease component [Amino acid transport and metabolism, Inorganic ion transport and metabolism];


Pssm-ID: 440366 [Multi-domain]  Cd Length: 314  Bit Score: 79.34  E-value: 8.89e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503427328  86 SQGRDLLSVILYGTRLSLTIGILAVAIQAFIGISIGLISG-YVGGRVDSFLMRFADVQLSFSTIMTAIVFLAIFQATFG- 163
Cdd:COG0601   82 VYGRPVSDLIAERLPVTLELALLALLLALLIGIPLGILAAlRRGSWLDRLITVLALLGISIPSFWLGLLLILLFAVKLGw 161

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503427328 164 ------VDTYEDLA-----MLMLILVIGLAEWPLFARTIRASVLAEKQKEYIDAARVMGIGKTRIMFRHILPNTLTPVLV 232
Cdd:COG0601  162 lpvsgrVSPWEDFLdalrhLILPALTLALGSLAGIARLTRSSMLEVLGQDYVRTARAKGLSERRVLLRHALRNALIPVVT 241


                 ..
gi 503427328 233 IF 234
Cdd:COG0601  242 VL 243
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 117-310 2.97e-13

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 66.94  E-value: 2.97e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503427328  117 GISIGLISG-YVGGRVDSFLMRFADVQLSFSTIMTAIVFLAIFQatFGVDTYEDLAMLMLILVIglaeWPLFARTIRASV 195
Cdd:pfam00528   1 GIPLGIIAAlRRGRRLDRLLRPLIDLLQALPSFVLAILLVVIAI--LSILGHGILPAIILALLG----WAGYARLIRRAA 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503427328  196 LAEKQKEYIDAARVMGIGKTRIMFRHILPNTLTPVLVIFTIQIANAIIAEAALSFLGLGmpstePSLGALISSGFRYLFS 275
Cdd:pfam00528  75 LRSLPSDLVEAARALGASRWQIFRKIILPNALPPILTGLALAFGGALGGAVLLEFLGSW-----PGLGLLLIEAILGYDY 149

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 503427328  276 GAWWicvIPSVALIGLILVMNLLGDWLRDYLNPRT 310
Cdd:pfam00528 150 PEIQ---GPVLAAALILLLLNLLVDILQRLLDPRV 181
FbpB COG1178
ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];
102-234 8.85e-04

ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440791 [Multi-domain]  Cd Length: 538  Bit Score: 40.91  E-value: 8.85e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503427328 102 SLTIGILAVAIQAFIGISIGLISGYVGGRVDSFLMRFADVQLSFSTIMTAIVFLAIFQATFGVDTYedLAMLMLILVIGL 181
Cdd:COG1178  343 SLLLALLAALLAVLLALLLAYLVRRRRGRLARLLDRLAMLPYAVPGIVLGLGLLLLFNRPLPLLLY--GTLAILVLAYVV 420

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 503427328 182 AEWPLFARTIRASvLAEKQKEYIDAARVMGIGKTRIMFRHILPNTLTPVLVIF 234
Cdd:COG1178  421 RFLPFALRSLEAA-LAQIDPSLEEAARSLGASPLRTLRRVTLPLLRPGLLAAA 472
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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