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Conserved domains on  [gi|503490471|ref|WP_013725132|]
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TIGR03905 family TSCPD domain-containing protein [Clostridium botulinum]

Protein Classification

TSCPD domain-containing protein( domain architecture ID 10576894)

TSCPD domain-containing protein similar to Pseudomonas aeruginosa class II ribonucleotides reductase (RNR) subunit NrdJb

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TSCPD pfam12637
TSCPD domain; This family of proteins is found in bacteria, archaea and viruses. The domain is ...
 4-77 1.18e-46

TSCPD domain; This family of proteins is found in bacteria, archaea and viruses. The domain is found in isolation in many proteins where it has a conserved C-terminal motif TSCPD after which the domain is named. Most copies of the domain possess 4 conserved cysteines that may be part of an Iron-sulfur cluster. This domain is found at the C-terminus of some ribonucleoside-diphosphate reductase enzymes.


:

Pssm-ID: 463651 [Multi-domain]  Cd Length: 74  Bit Score: 142.99  E-value: 1.18e-46
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 503490471   4 YNPKGVCSKEISFEIENNTLKNISFVGGCDGNLKGISSLVDGMDIDTVIKKLRGINCRGKGTSCPDQLAKALEE 77
Cdd:pfam12637  1 YKTKGTCSREIDFEVDDGIIKNVKFTGGCNGNLQGISALVEGMKVEEVIKRLEGIRCGFKGTSCPDQLAKALKE 74
 
Name Accession Description Interval E-value
TSCPD pfam12637
TSCPD domain; This family of proteins is found in bacteria, archaea and viruses. The domain is ...
 4-77 1.18e-46

TSCPD domain; This family of proteins is found in bacteria, archaea and viruses. The domain is found in isolation in many proteins where it has a conserved C-terminal motif TSCPD after which the domain is named. Most copies of the domain possess 4 conserved cysteines that may be part of an Iron-sulfur cluster. This domain is found at the C-terminus of some ribonucleoside-diphosphate reductase enzymes.


Pssm-ID: 463651 [Multi-domain]  Cd Length: 74  Bit Score: 142.99  E-value: 1.18e-46
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 503490471   4 YNPKGVCSKEISFEIENNTLKNISFVGGCDGNLKGISSLVDGMDIDTVIKKLRGINCRGKGTSCPDQLAKALEE 77
Cdd:pfam12637  1 YKTKGTCSREIDFEVDDGIIKNVKFTGGCNGNLQGISALVEGMKVEEVIKRLEGIRCGFKGTSCPDQLAKALKE 74
TIGR03905_4_Cys TIGR03905
uncharacterized protein TIGR03905; This model describes a family of conserved hypothetical ...
 2-79 3.10e-38

uncharacterized protein TIGR03905; This model describes a family of conserved hypothetical proteins of small size, typically ~85 residues, with four invariant Cys residues. This small protein is distantly homologous to a C-terminal domain found in proteins identified by N-terminal homology as ribonucleotide reductases. The rare and sporadic distribution of this protein family falls mostly within the subset of bacterial genomes containing the uncharacterized radical SAM protein modeled by TIGR03904. [Unknown function, General]


Pssm-ID: 188420  Cd Length: 78  Bit Score: 121.84  E-value: 3.10e-38
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 503490471   2 YTYNPKGVCSKEISFEIENNTLKNISFVGGCDGNLKGISSLVDGMDIDTVIKKLRGINCRGKGTSCPDQLAKALEELK 79
Cdd:TIGR03905  1 ITYITSGVCSTEIQFDIEGDKVKEVRFSGGCDGNLKAISKLVEGMPVKDVIQKLEGITCGDKATSCADQLAKALEQAA 78
PRK08665 PRK08665
vitamin B12-dependent ribonucleotide reductase;
30-77 4.19e-05

vitamin B12-dependent ribonucleotide reductase;


Pssm-ID: 236330 [Multi-domain]  Cd Length: 752  Bit Score: 39.92  E-value: 4.19e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 503490471  30 GGC-DGNLKGISSLVD-----GMDIDTVIKKLRGINC-------RGKGTSCPDQLAKALEE 77
Cdd:PRK08665 637 GGCaAAQSEAIGRLVSlalrsGVDVREIVKQLKGIRCpspagqgGNKVLSCPDAIAKVLEK 697
 
Name Accession Description Interval E-value
TSCPD pfam12637
TSCPD domain; This family of proteins is found in bacteria, archaea and viruses. The domain is ...
 4-77 1.18e-46

TSCPD domain; This family of proteins is found in bacteria, archaea and viruses. The domain is found in isolation in many proteins where it has a conserved C-terminal motif TSCPD after which the domain is named. Most copies of the domain possess 4 conserved cysteines that may be part of an Iron-sulfur cluster. This domain is found at the C-terminus of some ribonucleoside-diphosphate reductase enzymes.


Pssm-ID: 463651 [Multi-domain]  Cd Length: 74  Bit Score: 142.99  E-value: 1.18e-46
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 503490471   4 YNPKGVCSKEISFEIENNTLKNISFVGGCDGNLKGISSLVDGMDIDTVIKKLRGINCRGKGTSCPDQLAKALEE 77
Cdd:pfam12637  1 YKTKGTCSREIDFEVDDGIIKNVKFTGGCNGNLQGISALVEGMKVEEVIKRLEGIRCGFKGTSCPDQLAKALKE 74
TIGR03905_4_Cys TIGR03905
uncharacterized protein TIGR03905; This model describes a family of conserved hypothetical ...
 2-79 3.10e-38

uncharacterized protein TIGR03905; This model describes a family of conserved hypothetical proteins of small size, typically ~85 residues, with four invariant Cys residues. This small protein is distantly homologous to a C-terminal domain found in proteins identified by N-terminal homology as ribonucleotide reductases. The rare and sporadic distribution of this protein family falls mostly within the subset of bacterial genomes containing the uncharacterized radical SAM protein modeled by TIGR03904. [Unknown function, General]


Pssm-ID: 188420  Cd Length: 78  Bit Score: 121.84  E-value: 3.10e-38
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 503490471   2 YTYNPKGVCSKEISFEIENNTLKNISFVGGCDGNLKGISSLVDGMDIDTVIKKLRGINCRGKGTSCPDQLAKALEELK 79
Cdd:TIGR03905  1 ITYITSGVCSTEIQFDIEGDKVKEVRFSGGCDGNLKAISKLVEGMPVKDVIQKLEGITCGDKATSCADQLAKALEQAA 78
PRK08665 PRK08665
vitamin B12-dependent ribonucleotide reductase;
30-77 4.19e-05

vitamin B12-dependent ribonucleotide reductase;


Pssm-ID: 236330 [Multi-domain]  Cd Length: 752  Bit Score: 39.92  E-value: 4.19e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 503490471  30 GGC-DGNLKGISSLVD-----GMDIDTVIKKLRGINC-------RGKGTSCPDQLAKALEE 77
Cdd:PRK08665 637 GGCaAAQSEAIGRLVSlalrsGVDVREIVKQLKGIRCpspagqgGNKVLSCPDAIAKVLEK 697
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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