Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; A functionally uncharacterized subgroup of the Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA) subfamily which is part of the M14 family of metallocarboxypeptidases. ASTE catalyzes the fifth and last step in arginine catabolism by the arginine succinyltransferase pathway, and aspartoacylase (ASPA, also known as aminoacylase 2, and ACY-2; EC:3.5.1.15) cleaves N-acetyl L-aspartic acid (NAA) into aspartate and acetate. NAA is abundant in the brain, and hydrolysis of NAA by ASPA may help maintain white matter. ASPA is an NAA scavenger in other tissues. Mutations in the gene encoding ASPA cause Canavan disease (CD), a fatal progressive neurodegenerative disorder involving dysmyelination and spongiform degeneration of white matter in children. This enzyme binds zinc which is necessary for activity. Measurement of elevated NAA levels in urine is used in the diagnosis of CD.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503561936  24 DITPYKTGNGEIPYLYHFDSGVAGPHVMINALTHGNEVCGAIVVKELIDLAIQPRQGKLTLAFANVAAYLTFDSQHPDAS 103
Cdd:cd06910    1 DISPYKTGNTGIDYVHRFDSGQPGPHVMINALTHGNEICGAIALDWLLKNGVRPLRGRLTFCFANVEAYERFDPARPTAS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503561936 104 RFVDQDLNRVWTKEILDDlSQDSTELQRARQLRPIIDEVDVLLDLHSMHEKCPPLCVCGPQDKGLELALEQQSPAWIIRD 183
Cdd:cd06910   81 RFVDEDLNRVWGPELLDG-PEQSIELRRARELRPVVDTVDYLLDIHSMQEKVPPLALAGDKEKGRALARRVGSPAHLLID 159

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 503561936 184 EGHPEGCRMRDYADFGDPNSTKNALLVECGQHWESSAVTVARDVTARFL 232
Cdd:cd06910  160 AGHAEGLRLRDYAGFGDPSSPKNALLVECGQHWERSAVVVALDITLRFL 208

Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; A functionally uncharacterized subgroup of the Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA) subfamily which is part of the M14 family of metallocarboxypeptidases. ASTE catalyzes the fifth and last step in arginine catabolism by the arginine succinyltransferase pathway, and aspartoacylase (ASPA, also known as aminoacylase 2, and ACY-2; EC:3.5.1.15) cleaves N-acetyl L-aspartic acid (NAA) into aspartate and acetate. NAA is abundant in the brain, and hydrolysis of NAA by ASPA may help maintain white matter. ASPA is an NAA scavenger in other tissues. Mutations in the gene encoding ASPA cause Canavan disease (CD), a fatal progressive neurodegenerative disorder involving dysmyelination and spongiform degeneration of white matter in children. This enzyme binds zinc which is necessary for activity. Measurement of elevated NAA levels in urine is used in the diagnosis of CD.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503561936  24 DITPYKTGNGEIPYLYHFDSGVAGPHVMINALTHGNEVCGAIVVKELIDLAIQPRQGKLTLAFANVAAYLTFDSQHPDAS 103
Cdd:cd06910    1 DISPYKTGNTGIDYVHRFDSGQPGPHVMINALTHGNEICGAIALDWLLKNGVRPLRGRLTFCFANVEAYERFDPARPTAS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503561936 104 RFVDQDLNRVWTKEILDDlSQDSTELQRARQLRPIIDEVDVLLDLHSMHEKCPPLCVCGPQDKGLELALEQQSPAWIIRD 183
Cdd:cd06910   81 RFVDEDLNRVWGPELLDG-PEQSIELRRARELRPVVDTVDYLLDIHSMQEKVPPLALAGDKEKGRALARRVGSPAHLLID 159

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 503561936 184 EGHPEGCRMRDYADFGDPNSTKNALLVECGQHWESSAVTVARDVTARFL 232
Cdd:cd06910  160 AGHAEGLRLRDYAGFGDPSSPKNALLVECGQHWERSAVVVALDITLRFL 208

Succinylglutamate desuccinylase / Aspartoacylase family; This family includes Succinylglutamate desuccinylase EC:3.1.-.- that catalyzes the fifth and last step in arginine catabolism by the arginine succinyltransferase pathway. The family also include aspartoacylase EC:3.5.1.15 which cleaves acylaspartate into a fatty acid and aspartate. Mutations in Swiss:P45381 lead to Canavan disease. This family is probably structurally related to pfam00246 (Bateman A pers. obs.).

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503561936   46 AGPHVMINALTHGNEVCGAIVVKELI-DLAIQPRQGKLTLA-FANVAAYLTfdsqhpdASRFVDQDLNRVWTKEILDDLS 123
Cdd:pfam04952   1 PGPTLLLSAGIHGNETNGVELLRRLLrQLDPGDIAGERTLVpLANPPAFRA-------GSRYIPRDLNRSFPGRALGASS 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503561936  124 QDSTELQRARQL-----RPIIDEVDVLLDLHS--MHEKCPPLCVCgPQDKGLELALE----QQSPAWIIRDEGHPEGCRM 192
Cdd:pfam04952  74 DEPYRATRAERLadlffPALLPRADIVLDLHTgtRGMGHLLFALA-PIRDDPLHLLAllraFGAPAVLKLHSKPSAGFSA 152

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 503561936  193 RDYADFGdpnstKNALLVECGQ--HWESSAVTVARDVTARFLMLHGLIQYKDLPSDWFQP 250
Cdd:pfam04952 153 FSAEELG-----APGFTLELGGagPFGANLISRTAAGVLNVLRLIGVLNGGPDAFEPPKL 207

Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; A functionally uncharacterized subgroup of the Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA) subfamily which is part of the M14 family of metallocarboxypeptidases. ASTE catalyzes the fifth and last step in arginine catabolism by the arginine succinyltransferase pathway, and aspartoacylase (ASPA, also known as aminoacylase 2, and ACY-2; EC:3.5.1.15) cleaves N-acetyl L-aspartic acid (NAA) into aspartate and acetate. NAA is abundant in the brain, and hydrolysis of NAA by ASPA may help maintain white matter. ASPA is an NAA scavenger in other tissues. Mutations in the gene encoding ASPA cause Canavan disease (CD), a fatal progressive neurodegenerative disorder involving dysmyelination and spongiform degeneration of white matter in children. This enzyme binds zinc which is necessary for activity. Measurement of elevated NAA levels in urine is used in the diagnosis of CD.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503561936  24 DITPYKTGNGEIPYLYHFDSGVAGPHVMINALTHGNEVCGAIVVKELIDLAIQPRQGKLTLAFANVAAYLTFDSQHPDAS 103
Cdd:cd06910    1 DISPYKTGNTGIDYVHRFDSGQPGPHVMINALTHGNEICGAIALDWLLKNGVRPLRGRLTFCFANVEAYERFDPARPTAS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503561936 104 RFVDQDLNRVWTKEILDDlSQDSTELQRARQLRPIIDEVDVLLDLHSMHEKCPPLCVCGPQDKGLELALEQQSPAWIIRD 183
Cdd:cd06910   81 RFVDEDLNRVWGPELLDG-PEQSIELRRARELRPVVDTVDYLLDIHSMQEKVPPLALAGDKEKGRALARRVGSPAHLLID 159

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 503561936 184 EGHPEGCRMRDYADFGDPNSTKNALLVECGQHWESSAVTVARDVTARFL 232
Cdd:cd06910  160 AGHAEGLRLRDYAGFGDPSSPKNALLVECGQHWERSAVVVALDITLRFL 208

Succinylglutamate desuccinylase/aspartoacylase; uncharacterized; A functionally uncharacterized subgroup of the Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA) subfamily which is part of the M14 family of metallocarboxypeptidases. ASTE catalyzes the fifth and last step in arginine catabolism by the arginine succinyltransferase pathway, and aspartoacylase (ASPA, also known as aminoacylase 2, and ACY-2; EC:3.5.1.15) cleaves N-acetyl L-aspartic acid (NAA) into aspartate and acetate. NAA is abundant in the brain, and hydrolysis of NAA by ASPA may help maintain white matter. ASPA is an NAA scavenger in other tissues. Mutations in the gene encoding ASPA cause Canavan disease (CD), a fatal progressive neurodegenerative disorder involving dysmyelination and spongiform degeneration of white matter in children. This enzyme binds zinc which is necessary for activity. Measurement of elevated NAA levels in urine is used in the diagnosis of CD.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503561936  50 VMINALTHGNEVCGAIVVKELID--LAIQPRQGKLTLAFANVAAYltfdsqhPDASRFVDQDLNRVWTKeildDLSQDST 127
Cdd:cd18430    1 LAVLGAVHGNETCGTRAVERLLAelPSGALQKGPVTLVPANERAY-------AEGVRFCEEDLNRVFPG----DPDPDTY 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503561936 128 ELQRARQLRPIIDEVDVLLDLHSMHEKCPPLCVCGPQDKGLELaleqqspawIIRDEGHPEGCRMRD----YADFGDPNS 203
Cdd:cd18430   70 ERRLANRLCPELEGHDVVLDLHSTHSGGQPFAILDYGDKASRR---------LARSVGIPKGWRVVYgrdlGYAHGGGKT 140

                        170       180
                 ....*....|....*....|.
gi 503561936 204 TKNALLVECGQHWESSAVTVA 224
Cdd:cd18430  141 EVTGVTVECGYHDSEEAAEVA 161

Peptidase M14 Aspartoacylase (ASPA) subfamily; Aspartoacylase (ASPA) belongs to the Succinylglutamate desuccinylase/aspartoacylase subfamily of the M14 family of metallocarboxypeptidases. ASPA (also known as aminoacylase 2; EC:3.5.1.15) cleaves N-acetyl L-aspartic acid (NAA) into aspartate and acetate. NAA is abundant in the brain, and hydrolysis of NAA by ASPA may help maintain white matter. ASPA is an NAA scavenger in other tissues. Mutations in the gene encoding ASPA cause Canavan disease (CD), a fatal progressive neurodegenerative disorder involving dysmyelination and spongiform degeneration of white matter in children. This enzyme binds zinc which is necessary for activity. Measurement of elevated NAA levels in urine is used in the diagnosis of CD.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503561936  50 VMINALTHGNEVCGAIVVKELI-DLAIQPRQGKLTLAF-ANVAAYltfdsqhpDAS-RFVDQDLNRVWTKEILDDLSQDS 126
Cdd:cd06909    3 VAIVGGTHGNELTGVYLVKHWLkNPELIERKSFEVHPLlANPRAV--------EQCrRYIDTDLNRCFSLENLSSAPSSL 74

                         90       100       110
                 ....*....|....*....|....*....|
gi 503561936 127 T-ELQRARQLRPII-----DEVDVLLDLHS 150
Cdd:cd06909   75 PyEVRRAREINQILgpkgnPACDFIIDLHN 104

Succinylglutamate desuccinylase / Aspartoacylase family; This family includes Succinylglutamate desuccinylase EC:3.1.-.- that catalyzes the fifth and last step in arginine catabolism by the arginine succinyltransferase pathway. The family also include aspartoacylase EC:3.5.1.15 which cleaves acylaspartate into a fatty acid and aspartate. Mutations in Swiss:P45381 lead to Canavan disease. This family is probably structurally related to pfam00246 (Bateman A pers. obs.).

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503561936   46 AGPHVMINALTHGNEVCGAIVVKELI-DLAIQPRQGKLTLA-FANVAAYLTfdsqhpdASRFVDQDLNRVWTKEILDDLS 123
Cdd:pfam04952   1 PGPTLLLSAGIHGNETNGVELLRRLLrQLDPGDIAGERTLVpLANPPAFRA-------GSRYIPRDLNRSFPGRALGASS 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503561936  124 QDSTELQRARQL-----RPIIDEVDVLLDLHS--MHEKCPPLCVCgPQDKGLELALE----QQSPAWIIRDEGHPEGCRM 192
Cdd:pfam04952  74 DEPYRATRAERLadlffPALLPRADIVLDLHTgtRGMGHLLFALA-PIRDDPLHLLAllraFGAPAVLKLHSKPSAGFSA 152

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 503561936  193 RDYADFGdpnstKNALLVECGQ--HWESSAVTVARDVTARFLMLHGLIQYKDLPSDWFQP 250
Cdd:pfam04952 153 FSAEELG-----APGFTLELGGagPFGANLISRTAAGVLNVLRLIGVLNGGPDAFEPPKL 207

Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; A functionally uncharacterized subgroup of the Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA) subfamily which is part of the M14 family of metallocarboxypeptidases. ASTE catalyzes the fifth and last step in arginine catabolism by the arginine succinyltransferase pathway, and aspartoacylase (ASPA, also known as aminoacylase 2, and ACY-2; EC:3.5.1.15) cleaves N-acetyl L-aspartic acid (NAA) into aspartate and acetate. NAA is abundant in the brain, and hydrolysis of NAA by ASPA may help maintain white matter. ASPA is an NAA scavenger in other tissues. Mutations in the gene encoding ASPA cause Canavan disease (CD), a fatal progressive neurodegenerative disorder involving dysmyelination and spongiform degeneration of white matter in children. This enzyme binds zinc which is necessary for activity. Measurement of elevated NAA levels in urine is used in the diagnosis of CD.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503561936  47 GPHVMINALTHGNEVCGAIVVKELIDlAIQPRQGKLTLAFANVAAYLTFDSQHpDASRFVDQDLNRVWTKEILDDLSQds 126
Cdd:cd06255   23 GPCLWINGAVHGDELNGPLAALELFR-ELDPAQLSGTLVATPIANPLAFQGRQ-KFSPQDGEDLDQSFPGDPDGLITE-- 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503561936 127 telQRARQLRPIIDEV-DVLLDLHSMHE----------KCPPLCVCGPQDKGLELAleqqspawiiRDEGHPEGCRMRDY 195
Cdd:cd06255   99 ---RMAHALFSEVKEVaDYLIDFHTGGTpfdanpytvyKLFPESGPVEEKRLLRLA----------RAFGVHANCRVDVS 165

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 503561936 196 ADFGDPNSTKN-------------ALLVECG--QHWESSAVTVARD 226
Cdd:cd06255  166 GAGGELPGNTAgaldyqcmaqgipAFMVELGggGRAEEEAVRFAAR 211

Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; A functionally uncharacterized subgroup of the Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA) subfamily which is part of the M14 family of metallocarboxypeptidases. ASTE catalyzes the fifth and last step in arginine catabolism by the arginine succinyltransferase pathway, and aspartoacylase (ASPA, also known as aminoacylase 2, and ACY-2; EC:3.5.1.15) cleaves N-acetyl L-aspartic acid (NAA) into aspartate and acetate. NAA is abundant in the brain, and hydrolysis of NAA by ASPA may help maintain white matter. ASPA is an NAA scavenger in other tissues. Mutations in the gene encoding ASPA cause Canavan disease (CD), a fatal progressive neurodegenerative disorder involving dysmyelination and spongiform degeneration of white matter in children. This enzyme binds zinc which is necessary for activity. Measurement of elevated NAA levels in urine is used in the diagnosis of CD.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503561936  45 VAGPHVMINALTHGNEVCGaivVKELIDLA--IQPRQ--GKLTLA-FANVAAYLTfdsqHPDASRFVD-QDLNRVWTKei 118
Cdd:cd06254    9 KPGPTLLITAGIHGGEYPG---ILAAIRLAreLDPADvkGTLIIVhIANVSGFEA----RTPFVVPEDgKNLNRVFPG-- 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503561936 119 lddlSQDSTELQRARQL--RPIIDEVDVLLDLHS--MHEK-CPPLCVCG---PQ--DKGLELALEQQSPAwIIRDEGHPE 188
Cdd:cd06254   80 ----DPDGTLTERIAYFltREIISRADFLIDLHGgdANEAlTPFVYYPGgasEEvnDISRAAAQALGLPY-IVISSSEKG 154

                        170       180
                 ....*....|....*....|....*.
gi 503561936 189 GCRMRDYADFGDPnstknALLVECGQ 214
Cdd:cd06254  155 TGYYSYAALRGIP-----SILVERGG 175

Peptidase M14 carboxypeptidase Csd4 and similar proteins; This family includes peptidase M14 carboxypeptidase Csd4 from H. pylori which has been shown to be DL-carboxypeptidase with a modified zinc binding site containing a glutamine residue in place of a conserved histidine. It is an archetype of a new carboxypeptidase subfamily with a domain arrangement that differs from this family of peptide-cleaving enzymes. Csd4 plays a role in trimming uncrosslinked peptidoglycan peptide chains by cleaving the amide bond between meso-diaminopimelate and iso-D-glutamic acid in truncated peptidoglycan side chains. It acts as a cell shape determinant, similar to Campylobacter jejuni Pgp1. The M14 family of metallocarboxypeptidases (MCPs), also known as funnelins, are zinc-binding carboxypeptidases (CPs) which hydrolyze single, C-terminal amino acids from polypeptide chains, and have a recognition site for the free C-terminal carboxyl group, which is a key determinant of specificity. Two major subfamilies of the M14 family, defined based on sequence and structural homology, are the A/B and N/E subfamilies. Enzymes belonging to the A/B subfamily are normally synthesized as inactive precursors containing preceding signal peptide, followed by an N-terminal pro-region linked to the enzyme; these proenzymes are called procarboxypeptidases. The A/B enzymes can be further divided based on their substrate specificity; Carboxypeptidase A-like (CPA-like) enzymes favor hydrophobic residues while carboxypeptidase B-like (CPB-like) enzymes only cleave the basic residues lysine or arginine. The A forms have slightly different specificities, with Carboxypeptidase A1 (CPA1) preferring aliphatic and small aromatic residues, and CPA2 preferring the bulky aromatic side chains. Enzymes belonging to the N/E subfamily enzymes are not produced as inactive precursors and instead rely on their substrate specificity and subcellular compartmentalization to prevent inappropriate cleavage. They contain an extra C-terminal transthyretin-like domain, thought to be involved in folding or formation of oligomers. MCPs can also be classified based on their involvement in specific physiological processes; the pancreatic MCPs participate only in alimentary digestion and include carboxypeptidase A and B (A/B subfamily), while others, namely regulatory MCPs or the N/E subfamily, are involved in more selective reactions, mainly in non-digestive tissues and fluids, acting on blood coagulation/fibrinolysis, inflammation and local anaphylaxis, pro-hormone and neuropeptide processing, cellular response and others. Another MCP subfamily, is that of succinylglutamate desuccinylase /aspartoacylase, which hydrolyzes N-acetyl-L-aspartate (NAA), and deficiency in which is the established cause of Canavan disease. Another subfamily (referred to as subfamily C) includes an exceptional type of activity in the MCP family, that of dipeptidyl-peptidase activity of gamma-glutamyl-(L)-meso-diaminopimelate peptidase I which is involved in bacterial cell wall metabolism.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503561936  34 EIPYLYHFDSgVAGPHVMINALTHGNEVCGAIVVKELIDLAIqpRQGKL-TLAFANVAAYLTfdsqhpdASRFVDQDLNR 112
Cdd:cd06243    4 EKPFTRLEGR-EPGPTLLIIGGIQGDEPGGFLAADLLADLYL--VKGNViVVPRLNFPSILR-------NHRGLNGDMNR 73

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 503561936 113 VWtkeilDDLSQDSTELQRARQLRPIIDE--VDVLLDLH 149
Cdd:cd06243   74 KF-----AALDKKDPEYKTIQEIKSLIADfrPDVVLHLH 107

Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; A functionally uncharacterized subgroup of the Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA) subfamily which is part of the M14 family of metallocarboxypeptidases. ASTE catalyzes the fifth and last step in arginine catabolism by the arginine succinyltransferase pathway, and aspartoacylase (ASPA, also known as aminoacylase 2, and ACY-2; EC:3.5.1.15) cleaves N-acetyl L-aspartic acid (NAA) into aspartate and acetate. NAA is abundant in the brain, and hydrolysis of NAA by ASPA may help maintain white matter. ASPA is an NAA scavenger in other tissues. Mutations in the gene encoding ASPA cause Canavan disease (CD), a fatal progressive neurodegenerative disorder involving dysmyelination and spongiform degeneration of white matter in children. This enzyme binds zinc which is necessary for activity. Measurement of elevated NAA levels in urine is used in the diagnosis of CD.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503561936  46 AGPHVMINALTHGNEVCGAIVVKELI-DLAIQPRQGKLTLA-FANVAAYLtfdsqhpdASRFV----DQDLNRVWtkeiL 119
Cdd:cd06252   33 SGPTVLLTGGNHGDEYEGPIALRRLArDLDPEDVRGRLIIVpALNLPAVR--------AGTRTspldGGNLNRAF----P 100

                         90       100       110
                 ....*....|....*....|....*....|...
gi 503561936 120 DDlsQDSTELQR-ARQL-RPIIDEVDVLLDLHS 150
Cdd:cd06252  101 GD--ADGTPTERiAHFLeTVLLPRADAVIDLHS 131