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Conserved domains on  [gi|503567645|ref|WP_013801721|]
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MULTISPECIES: tautomerase family protein [Delftia]

Protein Classification

tautomerase family protein( domain architecture ID 10629679)

tautomerase family protein similar to Haemophilus influenzae protein HI_1388.1 that reveals a tautomerase/MIF fold

CATH:  3.30.429.10
Gene Ontology:  GO:0016853|GO:0006725
PubMed:  29184004|12051677|18695941
SCOP:  3001770

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Tautomerase_2 pfam14552
Tautomerase enzyme;
38-119 1.11e-41

Tautomerase enzyme;


:

Pssm-ID: 434035  Cd Length: 82  Bit Score: 132.69  E-value: 1.11e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503567645   38 DQFMTITEHDGDNFRYGASYLGVARSDDLVLVQLTVSNTRSLEQKKALFRRIAELLVESPGLRPEDVFVNLVEVDKENWS 117
Cdd:pfam14552   1 DRFQIIHEHDPEDFVYPPTYLGIERSDDYVIIQITLFAGRSVEQKKALYRALAERLAAKLGIRPEDVFIVLVENPKENWS 80


                  ..
gi 503567645  118 MG 119
Cdd:pfam14552  81 FG 82
PptA COG1942
Phenylpyruvate tautomerase PptA, 4-oxalocrotonate tautomerase family [Secondary metabolites ...
 2-54 1.93e-04

Phenylpyruvate tautomerase PptA, 4-oxalocrotonate tautomerase family [Secondary metabolites biosynthesis, transport and catabolism];


:

Pssm-ID: 441545  Cd Length: 58  Bit Score: 37.05  E-value: 1.93e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 503567645   2 PMTRINMRAGKSPAYRQAICDSLYRAMRETFNVPEDDQFMTITEHDGDNFRYG 54
Cdd:COG1942    1 PIINIKLFEGRTPEQKRALAKAVTDAVVEVLGKPPESVSVVIEEVPPENWGIG 53
 
Name Accession Description Interval E-value
Tautomerase_2 pfam14552
Tautomerase enzyme;
38-119 1.11e-41

Tautomerase enzyme;


Pssm-ID: 434035  Cd Length: 82  Bit Score: 132.69  E-value: 1.11e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503567645   38 DQFMTITEHDGDNFRYGASYLGVARSDDLVLVQLTVSNTRSLEQKKALFRRIAELLVESPGLRPEDVFVNLVEVDKENWS 117
Cdd:pfam14552   1 DRFQIIHEHDPEDFVYPPTYLGIERSDDYVIIQITLFAGRSVEQKKALYRALAERLAAKLGIRPEDVFIVLVENPKENWS 80


                  ..
gi 503567645  118 MG 119
Cdd:pfam14552  81 FG 82
PptA COG1942
Phenylpyruvate tautomerase PptA, 4-oxalocrotonate tautomerase family [Secondary metabolites ...
 68-119 1.05e-13

Phenylpyruvate tautomerase PptA, 4-oxalocrotonate tautomerase family [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 441545  Cd Length: 58  Bit Score: 60.93  E-value: 1.05e-13
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 503567645  68 LVQLTVSNTRSLEQKKALFRRIAELLVESPGLRPEDVFVNLVEVDKENWSMG 119
Cdd:COG1942    2 IINIKLFEGRTPEQKRALAKAVTDAVVEVLGKPPESVSVVIEEVPPENWGIG 53
4Oxalocrotonate_Tautomerase cd00491
4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The ...
 69-119 5.09e-08

4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one dimer and the third from a neighboring monomer. Each monomer is a beta-alpha-beta fold with two small beta strands at the C-terminus that fold back on themselves. A pair of monomers form a dimer with two-fold symmetry, consisting of a 4-stranded beta sheet with two helices on one side and two additional small beta strands at each end. The dimers are assembled around a 3-fold axis of rotation to form a hexamer, with the short beta strands from each dimer contacting the neighboring dimers.


Pssm-ID: 238274  Cd Length: 58  Bit Score: 46.23  E-value: 5.09e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 503567645  69 VQLTVSNTRSLEQKKALFRRIAELLVESPGLRPEDVFVNLVEVDKENWSMG 119
Cdd:cd00491    3 VQIYILEGRTDEQKRELIERVTEAVSEILGAPEATIVVIIDEMPKENWGIG 53
PRK00745 PRK00745
4-oxalocrotonate tautomerase; Provisional
 77-119 2.72e-07

4-oxalocrotonate tautomerase; Provisional


Pssm-ID: 179107  Cd Length: 62  Bit Score: 44.71  E-value: 2.72e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 503567645  77 RSLEQKKALFRRIAELLVESPGLRPEDVFVNLVEVDKENWSMG 119
Cdd:PRK00745  12 RTVEQKRKLVEEITRVTVETLGCPPESVDIIITDVKRENWATG 54
taut TIGR00013
4-oxalocrotonate tautomerase family enzyme; 4-oxalocrotonate tautomerase is a homohexamer in ...
 77-119 1.52e-05

4-oxalocrotonate tautomerase family enzyme; 4-oxalocrotonate tautomerase is a homohexamer in which each monomer is very small, at about 62 amino acids. Pro-1 of the mature protein serves as a general base. The enzyme functions in meta-cleavage pathways of aromatic hydrocarbon catabolism. Because several Arg residues located near the active site in the crystal structure of Pseudomonas putida are not conserved among all members of this family, because the literature describes a general role in the isomerization of beta,gamma-unsaturated enones to their alpha,beta-isomers, and because of the presence of fairly distantly related paralogs in Campylobacter jejuni, the family is regarded as not necessarily uniform in function. [Energy metabolism, Other]


Pssm-ID: 129125  Cd Length: 63  Bit Score: 40.10  E-value: 1.52e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 503567645   77 RSLEQKKALFRRIAELLVESPGLRPEDVFVNLVEVDKENWSMG 119
Cdd:TIGR00013  12 RTDEQKRQLIEGVTEAMAETLGANLESIVVIIDEMPKNNYGIG 54
PptA COG1942
Phenylpyruvate tautomerase PptA, 4-oxalocrotonate tautomerase family [Secondary metabolites ...
 2-54 1.93e-04

Phenylpyruvate tautomerase PptA, 4-oxalocrotonate tautomerase family [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 441545  Cd Length: 58  Bit Score: 37.05  E-value: 1.93e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 503567645   2 PMTRINMRAGKSPAYRQAICDSLYRAMRETFNVPEDDQFMTITEHDGDNFRYG 54
Cdd:COG1942    1 PIINIKLFEGRTPEQKRALAKAVTDAVVEVLGKPPESVSVVIEEVPPENWGIG 53
 
Name Accession Description Interval E-value
Tautomerase_2 pfam14552
Tautomerase enzyme;
38-119 1.11e-41

Tautomerase enzyme;


Pssm-ID: 434035  Cd Length: 82  Bit Score: 132.69  E-value: 1.11e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503567645   38 DQFMTITEHDGDNFRYGASYLGVARSDDLVLVQLTVSNTRSLEQKKALFRRIAELLVESPGLRPEDVFVNLVEVDKENWS 117
Cdd:pfam14552   1 DRFQIIHEHDPEDFVYPPTYLGIERSDDYVIIQITLFAGRSVEQKKALYRALAERLAAKLGIRPEDVFIVLVENPKENWS 80


                  ..
gi 503567645  118 MG 119
Cdd:pfam14552  81 FG 82
PptA COG1942
Phenylpyruvate tautomerase PptA, 4-oxalocrotonate tautomerase family [Secondary metabolites ...
 68-119 1.05e-13

Phenylpyruvate tautomerase PptA, 4-oxalocrotonate tautomerase family [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 441545  Cd Length: 58  Bit Score: 60.93  E-value: 1.05e-13
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 503567645  68 LVQLTVSNTRSLEQKKALFRRIAELLVESPGLRPEDVFVNLVEVDKENWSMG 119
Cdd:COG1942    2 IINIKLFEGRTPEQKRALAKAVTDAVVEVLGKPPESVSVVIEEVPPENWGIG 53
4Oxalocrotonate_Tautomerase cd00491
4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The ...
 69-119 5.09e-08

4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one dimer and the third from a neighboring monomer. Each monomer is a beta-alpha-beta fold with two small beta strands at the C-terminus that fold back on themselves. A pair of monomers form a dimer with two-fold symmetry, consisting of a 4-stranded beta sheet with two helices on one side and two additional small beta strands at each end. The dimers are assembled around a 3-fold axis of rotation to form a hexamer, with the short beta strands from each dimer contacting the neighboring dimers.


Pssm-ID: 238274  Cd Length: 58  Bit Score: 46.23  E-value: 5.09e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 503567645  69 VQLTVSNTRSLEQKKALFRRIAELLVESPGLRPEDVFVNLVEVDKENWSMG 119
Cdd:cd00491    3 VQIYILEGRTDEQKRELIERVTEAVSEILGAPEATIVVIIDEMPKENWGIG 53
Tautomerase pfam01361
Tautomerase enzyme; This family includes the enzyme 4-oxalocrotonate tautomerase that ...
 77-119 2.44e-07

Tautomerase enzyme; This family includes the enzyme 4-oxalocrotonate tautomerase that catalyzes the ketonization of 2-hydroxymuconate to 2-oxo-3-hexenedioate.


Pssm-ID: 396090  Cd Length: 60  Bit Score: 44.59  E-value: 2.44e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 503567645   77 RSLEQKKALFRRIAELLVESPGLRPEDVFVNLVEVDKENWSMG 119
Cdd:pfam01361  11 RTDEQKKELIERVTDALVEVLGAPRSAIVVIIEEVPPENWGVG 53
PRK00745 PRK00745
4-oxalocrotonate tautomerase; Provisional
 77-119 2.72e-07

4-oxalocrotonate tautomerase; Provisional


Pssm-ID: 179107  Cd Length: 62  Bit Score: 44.71  E-value: 2.72e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 503567645  77 RSLEQKKALFRRIAELLVESPGLRPEDVFVNLVEVDKENWSMG 119
Cdd:PRK00745  12 RTVEQKRKLVEEITRVTVETLGCPPESVDIIITDVKRENWATG 54
taut TIGR00013
4-oxalocrotonate tautomerase family enzyme; 4-oxalocrotonate tautomerase is a homohexamer in ...
 77-119 1.52e-05

4-oxalocrotonate tautomerase family enzyme; 4-oxalocrotonate tautomerase is a homohexamer in which each monomer is very small, at about 62 amino acids. Pro-1 of the mature protein serves as a general base. The enzyme functions in meta-cleavage pathways of aromatic hydrocarbon catabolism. Because several Arg residues located near the active site in the crystal structure of Pseudomonas putida are not conserved among all members of this family, because the literature describes a general role in the isomerization of beta,gamma-unsaturated enones to their alpha,beta-isomers, and because of the presence of fairly distantly related paralogs in Campylobacter jejuni, the family is regarded as not necessarily uniform in function. [Energy metabolism, Other]


Pssm-ID: 129125  Cd Length: 63  Bit Score: 40.10  E-value: 1.52e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 503567645   77 RSLEQKKALFRRIAELLVESPGLRPEDVFVNLVEVDKENWSMG 119
Cdd:TIGR00013  12 RTDEQKRQLIEGVTEAMAETLGANLESIVVIIDEMPKNNYGIG 54
PptA COG1942
Phenylpyruvate tautomerase PptA, 4-oxalocrotonate tautomerase family [Secondary metabolites ...
 2-54 1.93e-04

Phenylpyruvate tautomerase PptA, 4-oxalocrotonate tautomerase family [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 441545  Cd Length: 58  Bit Score: 37.05  E-value: 1.93e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 503567645   2 PMTRINMRAGKSPAYRQAICDSLYRAMRETFNVPEDDQFMTITEHDGDNFRYG 54
Cdd:COG1942    1 PIINIKLFEGRTPEQKRALAKAVTDAVVEVLGKPPESVSVVIEEVPPENWGIG 53
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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