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Conserved domains on  [gi|503610770|ref|WP_013844846|]
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glutamate synthase large subunit [Sinorhizobium meliloti]

Protein Classification

glutamate synthase family protein( domain architecture ID 1000540)

glutamate synthase family protein catalyzes the single-step conversion of L-glutamine and alpha-ketoglutarate into two molecules of L-glutamate; such as ferredoxin-dependent glutamate synthases, which found only in plants and cyanobacteria, and bacterial NADPH-dependent glutamate synthase large subunit GltB

Gene Ontology:  GO:0015930|GO:0097054
PubMed:  11967268|31473159

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
gltB super family cl36051
glutamate synthase subunit alpha; Provisional
 34-1554 0e+00

glutamate synthase subunit alpha; Provisional


The actual alignment was detected with superfamily member PRK11750:

Pssm-ID: 236968 [Multi-domain]  Cd Length: 1485  Bit Score: 1782.50  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770   34 KQGLYDPRNEHDACGVGFVAHLKGEKSHQIVRDGLFMLENLTHRGAVGADPLMGDGAGILVQIPDRFFREEMAKQGVTLP 113
Cdd:PRK11750    2 HMGLYDPSLERDNCGFGLIAHMEGEPSHKLVRTAIHALARMTHRGGIAADGKTGDGCGLLLQKPDRFFRAVAEEAGWRLA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770  114 KagEYAVGYLFMPRDEALIAHFKEVISEVVAEEGQIVLGFRDVPVDNSSLSkapDIA-ATEPHHVQVFIGAGREAaSSDE 192
Cdd:PRK11750   82 K--NYAVGMVFLNQDPELAAAARRILEEELQRETLSVVGWREVPTNPSVLG---EIAlSSLPRIEQVFVNAPAGW-RERD 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770  193 FERRLFTLRKVISNRIYAEADggdlgFYIVSLSTTTIVYKGMFLAYQVGAYYKDLADERFQSAVALVHQRFSTNTFPSWK 272
Cdd:PRK11750  156 FERRLFIARRRIEKRLADDKD-----FYVCSLSNLVIIYKGLMMPADLPRFYLDLADLRLESAICVFHQRFSTNTLPRWP 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770  273 LAHPYRMVAHNGEINTLRGNVNWMAARQASVSSPLFgDDISKLWPISYEGQSDTACFDNALEFLVRGGYSLSHAVMMLIP 352
Cdd:PRK11750  231 LAQPFRYLAHNGEINTITGNRQWARARAYKFQTPLI-PDLQEAAPFVNETGSDSSSLDNMLELLLAGGMDLFRAMRLLVP 309

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770  353 EAWAGNQLMSPERKAFYEYHAALMEPWDGPAAVAFTDGRQIGATLDRNGLRPARYIVTSDDRVIMASEAGVLPVAEDKIV 432
Cdd:PRK11750  310 PAWQNNPDMDPDLRAFYEFNSMHMEPWDGPAGIVMTDGRYAACNLDRNGLRPARYVITKDKLITLASEVGIWDYQPDEVV 389

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770  433 KKWRLQPGKMLLIDMEEGRIISDEEVKSSLAGKHPYRQWLDNTQLILEELKPVEPRALRR----DVSLIDRQQAFGYTHE 508
Cdd:PRK11750  390 EKGRVGPGELLVIDTRTGRILHSAEIDNDLKSRHPYKEWLEKNVRRLVPFEELPDEQVGSreldDDTLKSYQKQFQYSFE 469

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770  509 DTKLLMSPMATTGQEAIGSMGTDTPISAMSDKPKLLYTYFKQNFAQVTNPPIDPIREELVMSLVSFIGPRPNILdHEGMA 588
Cdd:PRK11750  470 ELDQVIRVLAENGQEAVGSMGDDTPMAVLSSQPRSIYDYFRQQFAQVTNPPIDPLREAHVMSLATCIGREMNVF-CETEG 548

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770  589 HAKRLEVRQPILTNGDLEKIRSIGhtEDRFDTKTLDFTYDISRGaeGMLEMLDRLCERAEAAVKGGYNIIVLSDRQIGPD 668
Cdd:PRK11750  549 HAHRVIFKSPVLSYSDFKQLTTLD--EEHYRADTLDLNYDPEET--GLEAAIKRLCDEAEQAVRDGTVLLVLSDRNIAKG 624

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770  669 RVAIPALLATAAVHHHLIRKGLRTSVGLVVESGEPREIHHFCLLAGYGAEAINPYLAFDTLVDMHKRGEFPKEVDEKEVV 748
Cdd:PRK11750  625 RLPIPAAMAVGAVQHRLVDKGLRCDANIIVETASARDPHHFAVLLGFGATAVYPYLAYETLGDLVDTGEILKDYRQVMLN 704

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770  749 YRyiKAVGKGILKVMSKMGISTYQSYCGAQIFDAVGLSSALVGKYFFGTATTIEGIGLEEIAAETVARHKAAFgsdpvLA 828
Cdd:PRK11750  705 YR--KGINKGLYKIMSKMGISTIASYRGSQLFEAVGLHDDVVDLCFKGVVSRIGGASFEDFEQDQKNLSKRAW-----LA 777

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770  829 N-TLDIGGEYAFRMRGESHAWTPDAIASLQHAVR-GNAEDrYREFSAMMNESAsrMNTIRGLFTIKGAEEvgrkPIPIEE 906
Cdd:PRK11750  778 RkPIDQGGLLKYVHGGEYHAYNPDVVNTLQKAVQsGDYSD-YQEYAKLVNERP--VATLRDLLALKPADN----PIPLDE 850

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770  907 VEPAAEIVKRFSTGAMSFGSISREAHTTLAVAMNRIGGKSNTGEGGEESDRYlplpdgstNPER-SAIKQIASGRFGVTT 985
Cdd:PRK11750  851 VEPAEELFKRFDSAAMSIGALSPEAHEALAIAMNRLGGRSNSGEGGEDPARY--------GTEKvSKIKQVASGRFGVTP 922

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770  986 EYLVNADVLQIKVAQGAKPGEGGQLPGHKVDATVAKTRHSTPGVGLISPPPHHDIYSIEDLAQLIYDLKNVNPEADVSVK 1065
Cdd:PRK11750  923 AYLVNAEVLQIKVAQGAKPGEGGQLPGDKVNPLIARLRYSVPGVTLISPPPHHDIYSIEDLAQLIFDLKQVNPKALVSVK 1002

                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770 1066 LVSEVGVGTVAAGVAKARADHITIAGFDGGTGASPLTSLKHAGSPWEIGLAETQQTLVLNGLRSRIALQVDGGLKTGRDV 1145
Cdd:PRK11750 1003 LVSEPGVGTIATGVAKAYADLITISGYDGGTGASPLTSVKYAGSPWELGLAETHQALVANGLRHKIRLQVDGGLKTGLDV 1082

                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770 1146 VIGALLGADEFGFATAPLIAAGCIMMRKCHLNTCPVGVATQDPVLRKR-FKGTPEHVVNYFFFVAEEVREILASLGARRL 1224
Cdd:PRK11750 1083 IKAAILGAESFGFGTGPMVALGCKYLRICHLNNCATGVATQDEKLRKNhYHGLPEMVMNYFEFIAEETREWMAQLGVRSL 1162

                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770 1225 DDIIGSSDLLDR-DRMIEhwKARGLDFSRIFHKVEAPK-EATYWTERQNHPID-DILDRRLIEKAKLALETKVPVAFEAA 1301
Cdd:PRK11750 1163 EDLIGRTDLLEElEGETA--KQQKLDLSPLLETAEPPAgKALYCTEERNPPFDkGLLNEQMLQQAKPAIEAKQGGEFWFD 1240

                        1290      1300      1310      1320      1330      1340      1350      1360
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770 1302 IKNVDRSAGAMLSGALAKRWGHKGLKDDTIHVTLKGTAGQSFGAFLARGITFDLVGDGNDYVGKGLSGGRIIVRPPENAR 1381
Cdd:PRK11750 1241 IRNTDRSVGARLSGEIARRHGNQGMADAPIKLRFTGTAGQSFGVWNAGGLELYLEGDANDYVGKGMAGGKIVIRPPVGSA 1320

                        1370      1380      1390      1400      1410      1420      1430      1440
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770 1382 IVPHQSIIVGNTVLYGAISGECYFNGVAGERFAVRNSGAIAVVEGVGDHGCEYMTGGVVVVLGGTGRNFAAGMSGGVAYV 1461
Cdd:PRK11750 1321 FRSHETAIIGNTCLYGATGGKLFAAGRAGERFAVRNSGAIAVVEGIGDHGCEYMTGGIVCVLGKTGVNFGAGMTGGFAYV 1400

                        1450      1460      1470      1480      1490      1500      1510      1520
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770 1462 LDEEGDFARRCNMAMVELQPVPeeddmleklhhhggdlmhkgmvdvsgDMTRHdEERLYQLISNHLHYTGSVRAKEILDH 1541
Cdd:PRK11750 1401 LDEDGDFVDRVNHELVEILRVE--------------------------DLEIH-REHLRGLITEHVEETGSEWGEEILAN 1453

                        1530
                  ....*....|...
gi 503610770 1542 WADYRPKFRKVMP 1554
Cdd:PRK11750 1454 FDDYLRKFWLVKP 1466
 
Name Accession Description Interval E-value
gltB PRK11750
glutamate synthase subunit alpha; Provisional
 34-1554 0e+00

glutamate synthase subunit alpha; Provisional


Pssm-ID: 236968 [Multi-domain]  Cd Length: 1485  Bit Score: 1782.50  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770   34 KQGLYDPRNEHDACGVGFVAHLKGEKSHQIVRDGLFMLENLTHRGAVGADPLMGDGAGILVQIPDRFFREEMAKQGVTLP 113
Cdd:PRK11750    2 HMGLYDPSLERDNCGFGLIAHMEGEPSHKLVRTAIHALARMTHRGGIAADGKTGDGCGLLLQKPDRFFRAVAEEAGWRLA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770  114 KagEYAVGYLFMPRDEALIAHFKEVISEVVAEEGQIVLGFRDVPVDNSSLSkapDIA-ATEPHHVQVFIGAGREAaSSDE 192
Cdd:PRK11750   82 K--NYAVGMVFLNQDPELAAAARRILEEELQRETLSVVGWREVPTNPSVLG---EIAlSSLPRIEQVFVNAPAGW-RERD 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770  193 FERRLFTLRKVISNRIYAEADggdlgFYIVSLSTTTIVYKGMFLAYQVGAYYKDLADERFQSAVALVHQRFSTNTFPSWK 272
Cdd:PRK11750  156 FERRLFIARRRIEKRLADDKD-----FYVCSLSNLVIIYKGLMMPADLPRFYLDLADLRLESAICVFHQRFSTNTLPRWP 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770  273 LAHPYRMVAHNGEINTLRGNVNWMAARQASVSSPLFgDDISKLWPISYEGQSDTACFDNALEFLVRGGYSLSHAVMMLIP 352
Cdd:PRK11750  231 LAQPFRYLAHNGEINTITGNRQWARARAYKFQTPLI-PDLQEAAPFVNETGSDSSSLDNMLELLLAGGMDLFRAMRLLVP 309

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770  353 EAWAGNQLMSPERKAFYEYHAALMEPWDGPAAVAFTDGRQIGATLDRNGLRPARYIVTSDDRVIMASEAGVLPVAEDKIV 432
Cdd:PRK11750  310 PAWQNNPDMDPDLRAFYEFNSMHMEPWDGPAGIVMTDGRYAACNLDRNGLRPARYVITKDKLITLASEVGIWDYQPDEVV 389

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770  433 KKWRLQPGKMLLIDMEEGRIISDEEVKSSLAGKHPYRQWLDNTQLILEELKPVEPRALRR----DVSLIDRQQAFGYTHE 508
Cdd:PRK11750  390 EKGRVGPGELLVIDTRTGRILHSAEIDNDLKSRHPYKEWLEKNVRRLVPFEELPDEQVGSreldDDTLKSYQKQFQYSFE 469

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770  509 DTKLLMSPMATTGQEAIGSMGTDTPISAMSDKPKLLYTYFKQNFAQVTNPPIDPIREELVMSLVSFIGPRPNILdHEGMA 588
Cdd:PRK11750  470 ELDQVIRVLAENGQEAVGSMGDDTPMAVLSSQPRSIYDYFRQQFAQVTNPPIDPLREAHVMSLATCIGREMNVF-CETEG 548

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770  589 HAKRLEVRQPILTNGDLEKIRSIGhtEDRFDTKTLDFTYDISRGaeGMLEMLDRLCERAEAAVKGGYNIIVLSDRQIGPD 668
Cdd:PRK11750  549 HAHRVIFKSPVLSYSDFKQLTTLD--EEHYRADTLDLNYDPEET--GLEAAIKRLCDEAEQAVRDGTVLLVLSDRNIAKG 624

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770  669 RVAIPALLATAAVHHHLIRKGLRTSVGLVVESGEPREIHHFCLLAGYGAEAINPYLAFDTLVDMHKRGEFPKEVDEKEVV 748
Cdd:PRK11750  625 RLPIPAAMAVGAVQHRLVDKGLRCDANIIVETASARDPHHFAVLLGFGATAVYPYLAYETLGDLVDTGEILKDYRQVMLN 704

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770  749 YRyiKAVGKGILKVMSKMGISTYQSYCGAQIFDAVGLSSALVGKYFFGTATTIEGIGLEEIAAETVARHKAAFgsdpvLA 828
Cdd:PRK11750  705 YR--KGINKGLYKIMSKMGISTIASYRGSQLFEAVGLHDDVVDLCFKGVVSRIGGASFEDFEQDQKNLSKRAW-----LA 777

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770  829 N-TLDIGGEYAFRMRGESHAWTPDAIASLQHAVR-GNAEDrYREFSAMMNESAsrMNTIRGLFTIKGAEEvgrkPIPIEE 906
Cdd:PRK11750  778 RkPIDQGGLLKYVHGGEYHAYNPDVVNTLQKAVQsGDYSD-YQEYAKLVNERP--VATLRDLLALKPADN----PIPLDE 850

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770  907 VEPAAEIVKRFSTGAMSFGSISREAHTTLAVAMNRIGGKSNTGEGGEESDRYlplpdgstNPER-SAIKQIASGRFGVTT 985
Cdd:PRK11750  851 VEPAEELFKRFDSAAMSIGALSPEAHEALAIAMNRLGGRSNSGEGGEDPARY--------GTEKvSKIKQVASGRFGVTP 922

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770  986 EYLVNADVLQIKVAQGAKPGEGGQLPGHKVDATVAKTRHSTPGVGLISPPPHHDIYSIEDLAQLIYDLKNVNPEADVSVK 1065
Cdd:PRK11750  923 AYLVNAEVLQIKVAQGAKPGEGGQLPGDKVNPLIARLRYSVPGVTLISPPPHHDIYSIEDLAQLIFDLKQVNPKALVSVK 1002

                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770 1066 LVSEVGVGTVAAGVAKARADHITIAGFDGGTGASPLTSLKHAGSPWEIGLAETQQTLVLNGLRSRIALQVDGGLKTGRDV 1145
Cdd:PRK11750 1003 LVSEPGVGTIATGVAKAYADLITISGYDGGTGASPLTSVKYAGSPWELGLAETHQALVANGLRHKIRLQVDGGLKTGLDV 1082

                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770 1146 VIGALLGADEFGFATAPLIAAGCIMMRKCHLNTCPVGVATQDPVLRKR-FKGTPEHVVNYFFFVAEEVREILASLGARRL 1224
Cdd:PRK11750 1083 IKAAILGAESFGFGTGPMVALGCKYLRICHLNNCATGVATQDEKLRKNhYHGLPEMVMNYFEFIAEETREWMAQLGVRSL 1162

                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770 1225 DDIIGSSDLLDR-DRMIEhwKARGLDFSRIFHKVEAPK-EATYWTERQNHPID-DILDRRLIEKAKLALETKVPVAFEAA 1301
Cdd:PRK11750 1163 EDLIGRTDLLEElEGETA--KQQKLDLSPLLETAEPPAgKALYCTEERNPPFDkGLLNEQMLQQAKPAIEAKQGGEFWFD 1240

                        1290      1300      1310      1320      1330      1340      1350      1360
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770 1302 IKNVDRSAGAMLSGALAKRWGHKGLKDDTIHVTLKGTAGQSFGAFLARGITFDLVGDGNDYVGKGLSGGRIIVRPPENAR 1381
Cdd:PRK11750 1241 IRNTDRSVGARLSGEIARRHGNQGMADAPIKLRFTGTAGQSFGVWNAGGLELYLEGDANDYVGKGMAGGKIVIRPPVGSA 1320

                        1370      1380      1390      1400      1410      1420      1430      1440
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770 1382 IVPHQSIIVGNTVLYGAISGECYFNGVAGERFAVRNSGAIAVVEGVGDHGCEYMTGGVVVVLGGTGRNFAAGMSGGVAYV 1461
Cdd:PRK11750 1321 FRSHETAIIGNTCLYGATGGKLFAAGRAGERFAVRNSGAIAVVEGIGDHGCEYMTGGIVCVLGKTGVNFGAGMTGGFAYV 1400

                        1450      1460      1470      1480      1490      1500      1510      1520
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770 1462 LDEEGDFARRCNMAMVELQPVPeeddmleklhhhggdlmhkgmvdvsgDMTRHdEERLYQLISNHLHYTGSVRAKEILDH 1541
Cdd:PRK11750 1401 LDEDGDFVDRVNHELVEILRVE--------------------------DLEIH-REHLRGLITEHVEETGSEWGEEILAN 1453

                        1530
                  ....*....|...
gi 503610770 1542 WADYRPKFRKVMP 1554
Cdd:PRK11750 1454 FDDYLRKFWLVKP 1466
GltB1 COG0067
Glutamate synthase domain 1 [Amino acid transport and metabolism]; Glutamate synthase domain 1 ...
 28-1574 0e+00

Glutamate synthase domain 1 [Amino acid transport and metabolism]; Glutamate synthase domain 1 is part of the Pathway/BioSystem: Glutamine biosynthesis


Pssm-ID: 439837 [Multi-domain]  Cd Length: 1520  Bit Score: 1447.75  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770   28 PSGLPRKQGLYDPRNEHDACGVGFVAHLKGEKSHQIVRDGLFMLENLTHRGAVGADPLMGDGAGILVQIPDRFFREEMAK 107
Cdd:COG0067     4 NSGLPAAQGLYDPAFEHDACGVGFVAHIKGRKSHDIVEDALEALENLEHRGAVGADGKTGDGAGILIQIPDAFFRAEAAE 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770  108 QGVTLPKAGEYAVGYLFMPRDEALIAHFKEVISEVVAEEGQIVLGFRDVPVDNSSLSKApdIAATEPHHVQVFIGAGrEA 187
Cdd:COG0067    84 LGIELPEPGEYAVGMVFLPQDEAARAAARAIIEEILAEEGLTVLGWRDVPVDPSVLGET--ARATEPVIEQVFVARP-DG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770  188 ASSDEFERRLFTLRKVISNRIYAEADGGDlGFYIVSLSTTTIVYKGMFLAYQVGAYYKDLADERFQSAVALVHQRFSTNT 267
Cdd:COG0067   161 LDGDAFERKLYVARKRIEKAIRALGLDDE-DFYICSLSSRTIVYKGMLTPEQLGEFYPDLQDPRFESALALVHQRFSTNT 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770  268 FPSWKLAHPYRMVAHNGEINTLRGNVNWMAARQASVSSPLFGDDISKLWPISYEGQSDTACFDNALEFLVRGGYSLSHAV 347
Cdd:COG0067   240 FPSWPLAQPFRYLAHNGEINTLRGNRNWMRAREALLASPLFGDDLEKLLPIVNPGGSDSASLDNVLELLVLGGRSLPHAM 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770  348 MMLIPEAWAGNQLMSPERKAFYEYHAALMEPWDGPAAVAFTDGRQIGATLDRNGLRPARYIVTSDDRVIMASEAGVLPVA 427
Cdd:COG0067   320 MMLIPEAWENNPDMDPERRAFYEYHSALMEPWDGPAAIVFTDGRQIGATLDRNGLRPARYVVTKDGLVILASEVGVLDIP 399

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770  428 EDKIVKKWRLQPGKMLLIDMEEGRIISDEEVKSSLAGKHPYRQWLDNTQLILEELKPVEPRALRRDVSLIDRQQAFGYTH 507
Cdd:COG0067   400 PEDIVEKGRLQPGKMLLVDLEEGRIIDDEEIKAELAAAHPYGEWLKENRIRLEDLPEPEEEPAPDDDLLLRRQQAFGYTE 479

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770  508 EDTKLLMSPMATTGQEAIGSMGTDTPISAMSDKPKLLYTYFKQNFAQVTNPPIDPIREELVMSLVSFIGPRPNILDHEGM 587
Cdd:COG0067   480 EEELLLLLPMAAGGEEEGGSGGDDDPAALLSSSRLLLYYYFFQFFAQVTNPPPDIIREEVVSSLLTTGGGGNNLLLEEEE 559

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770  588 AHAKRLEVRQPILTNGDLEKIRSIGHTEDRFDTKTLDFTYDISRGAEGMLEMLDRLCERAEAAVKGGYNIIVLSDRQIGP 667
Cdd:COG0067   560 ARRRLLLLPPPLLNELLLLLLRLLDGDFKSTTTITLLDLADGAGGGAAAAAAAAEAAAAAAAAAVLLILIIDLSDDDSDA 639

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770  668 DRVAIPALLATAAVHHHLIRKGLRTSVGLVVESGEPREIHHFCLLAGYGAEAINPYLAFDTLVDMHKRGEfPKEVDEKEV 747
Cdd:COG0067   640 APAPLAAAAAAHHHHLHLLRRRTRLLVVVEVEAVEHHHHHLLLGGGGAAAAAAALYLALELLLDGLLLGL-EDAAAAAAA 718

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770  748 VYRYIKAVGKGILKVMSKMGISTYQSYCGAQIFDAVGLSSALVGKYFFGTATTIEGIGLEEIAAETVARHKAAFGSDPVL 827
Cdd:COG0067   719 KKKKKKKKGKLKKKKMSGIISSSSGSYGAAAIFGALGLVVVVFFTFTTTTGGGGGGGGLDEEAEEEAARAAAAAAEPGGL 798

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770  828 ANTLDIGGEYAFRMRGESHAWTPDAIASLQHAVRGNAEDRYREFSAMMNESASRMNTIRGLFTIKGAEEVgrkPIPIEEV 907
Cdd:COG0067   799 LLGLGGGGGGEYGRRREGELHLLLQAATAAAAAAYRAYKYYRFARYTALLDLLRLLLLLLLLLFEEEEEE---EEPEEEE 875

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770  908 EPAAEIVKRFSTGAMSFGSISREAHTTLAVAMNRIGGKSNTGEGGEESDRylplpdGSTNPERSAIKQIASGRFGVTTEY 987
Cdd:COG0067   876 EEEESSAIAAASSAAASAAASAAAAAAAAGAGGGGGGGGGGGGGGGEGRR------ASGGSGSSSSASVAAAGGGVVVGA 949

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770  988 LVNADVLQIKVAQGAKPGEGGQLPGHKVDATVAKTRHSTPGVGLISPPPHHDIYSIEDLAQLIYDLKNVNPEADVSVKLV 1067
Cdd:COG0067   950 GAAAAEGGGGGGGGGGGGGGGGGGGGGGVPGIAPPPPHPPPPGIILPPPPHDIIIIIILLLLILLLLALVAVAAAVAVVV 1029

                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770 1068 SEVGVGTVAAGVAKARADHITIAGFDGGTGASPLTSLKHAGSPWEIGLAETQQTLVLNGLRSRIALQVDGGLKTGRDVVI 1147
Cdd:COG0067  1030 VAAAAGVAAAAAAAAAAAAVGSSGGGGGGGGGGGGSGAAGALGALGLLGLLLLLLLLLLLLLLGVVVLGGLGGGGGGGGG 1109

                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770 1148 GALLGADEFGFATAPLIAAGCIMMRKCHLNTCPVGVATQDPVLRKRFKGTPEHVVNYFFFVAEEVREILASLGARRLDDI 1227
Cdd:COG0067  1110 AAALGAGALGGGAAALVVVGCGVAMCCVVLLCTVGGAAAGELERRRFRFAGEEVVVEEFFEAAEEEEEEALLELLRLLEE 1189

                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770 1228 IGSSDLLDRDRMIEHWKARGLDFSRIFHKVEAPKEATYWTERQNHPIDDILDRRLI--EKAKLALETKVPVAFEAAIKNV 1305
Cdd:COG0067  1190 GLGVVELLLLLLLLLLLAKLLLLLLLLLLPLLPPDDPRDLALEEDDELLLLLALLLllLALALALLAAVRVALRAALGRA 1269

                        1290      1300      1310      1320      1330      1340      1350      1360
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770 1306 DRSAGAMLSGALAKRWGHKGLKDDTIHVTLKGTAGQSFGAFLARGITFDLVGDGNDYVGKGLSGGRIIVRPPENARIVPH 1385
Cdd:COG0067  1270 RRRGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGG 1349

                        1370      1380      1390      1400      1410      1420      1430      1440
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770 1386 QSIIVGNTVLYGAISGECYFNGVAGERFAVRNSGAIAVVEGVGDHGCEYMTGGVVVVLGGTGRNFAAGMSGGVAYVLDEE 1465
Cdd:COG0067  1350 GGGGGGGAGGGGGGGGGAGGGGGGGGGGVGGGGGGGGVGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGLDL 1429

                        1450      1460      1470      1480      1490      1500      1510      1520
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770 1466 GDFARRCNMAMVELQPVPEEDDMLEKLHHHGGdlmhkgmvdvsgdmtrhdeerlyqlisnHLHYTGSVRAKEILDHWADY 1545
Cdd:COG0067  1430 DVVLDEEEEEELEELLLLLEEEEEEELELEEE----------------------------EAELLELADAALLLLLLVKV 1481

                        1530      1540
                  ....*....|....*....|....*....
gi 503610770 1546 RPKFRKVMPVEYRRALEDMERMKMAEAAE 1574
Cdd:COG0067  1482 KAAVKVLLLLLLAAAAAAAEAAAAAAAAA 1510
GATase_2 pfam00310
Glutamine amidotransferases class-II;
47-471 0e+00

Glutamine amidotransferases class-II;


Pssm-ID: 395245 [Multi-domain]  Cd Length: 420  Bit Score: 759.82  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770    47 CGVGFVAHLKGEKSHQIVRDGLFMLENLTHRGAVGADPLMGDGAGILVQIPDRFFREEMAKQGVTLPKAGEYAVGYLFMP 126
Cdd:pfam00310    1 CGVGFIAHIKGKPSHKIVEDALEALENMEHRGACGADPDTGDGAGILTQIPDEFFRKEAKELGIELPEAGQYAVGMVFLP 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770   127 RDEALIAHFKEVISEVVAEEGQIVLGFRDVPVDNSSLSKAPdiAATEPHHVQVFIGAGrEAASSDEFERRLFTLRKVISN 206
Cdd:pfam00310   81 QDEAKRAEAKKIFEEIAEEEGLEVLGWREVPTNNSVLGEAA--LESEPQIEQVFVGSP-AGKSEDDFERKLYVARKRIEK 157

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770   207 RIYAEADGGDlgFYIVSLSTTTIVYKGMFLAYQVGAYYKDLADERFQSAVALVHQRFSTNTFPSWKLAHPYRMVAHNGEI 286
Cdd:pfam00310  158 EIGVEGGDKD--FYICSLSSRTIVYKGMLTPEQLGQFYLDLQDPRFESAFALVHSRFSTNTFPSWPLAQPMRFLAHNGEI 235

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770   287 NTLRGNVNWMAARQASVSSPLFGDDISKLWPISYEGQSDTACFDNALEFLVRGGYSLSHAVMMLIPEAWAGNQLMSPERK 366
Cdd:pfam00310  236 NTLRGNRNWMRAREALLKSELFGDDLDKLLPIVNPGGSDSASLDNVLELLVLGGRSLPEALMMLIPEAWQNNPSMDPEKR 315

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770   367 AFYEYHAALMEPWDGPAAVAFTDGRQIGATLDRNGLRPARYIVTSDDRVIMASEAGVLPVAEDKIVKKWRLQPGKMLLID 446
Cdd:pfam00310  316 AFYEYHSGLMEPWDGPALIVFTDGRYVGATLDRNGLRPARYYITKDGLIILASEVGVLDIPPERVVEKGRLGPGRMLLVD 395

                          410       420
                   ....*....|....*....|....*
gi 503610770   447 MEEGRIISDEEVKSSLAGKHPYRQW 471
Cdd:pfam00310  396 LEEGRIIDDEEIKQQIASRHPYGEW 420
GltS cd00713
Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a ...
 47-466 0e+00

Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The N-terminal glutaminase domain catalyzes the hydrolysis of glutamine to glutamic acid and ammonia, and has a fold similar to that of other glutamine amidotransferases such as glucosamine-fructose 6-phosphate synthase (GLMS or GFAT), glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase), asparagine synthetase B (AsnB), and beta lactam synthetase (beta-LS), as well as the Ntn hydrolase folds of the proteasomal alpha and beta subunits.


Pssm-ID: 238365 [Multi-domain]  Cd Length: 413  Bit Score: 724.70  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770   47 CGVGFVAHLKGEKSHQIVRDGLFMLENLTHRGAVGADPLMGDGAGILVQIPDRFFREEMAKQGVTLPKAGEYAVGYLFMP 126
Cdd:cd00713     1 CGVGFVANIDGKPSHDIVQDALEALERMEHRGGVGADGKTGDGAGILIQIPHEFFREELAEAGIELPEAGEYAVGMLFLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770  127 RDEALIAHFKEVISEVVAEEGQIVLGFRDVPVDNSSLSkaPDIAATEPHHVQVFIGAgREAASSDEFERRLFTLRKVISN 206
Cdd:cd00713    81 RDEEAREAAKAIIEEELEAEGLRVLGWRDVPVDNSVLG--PTARATEPLIEQVFVGA-PSGDDGEAFERKLYLLRKRIEK 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770  207 RIYAEADGgdlgFYIVSLSTTTIVYKGMFLAYQVGAYYKDLADERFQSAVALVHQRFSTNTFPSWKLAHPYRMVAHNGEI 286
Cdd:cd00713   158 AIRAADED----FYVCSLSSRTIVYKGMLLPEQLGQFYPDLQDPRFESAFALVHSRFSTNTFPSWPLAQPFRYLAHNGEI 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770  287 NTLRGNVNWMAARQASVSSPLFGDDISKLWPISYEGQSDTACFDNALEFLVRGGYSLSHAVMMLIPEAWAGNQLMSPERK 366
Cdd:cd00713   234 NTIRGNRNWMRAREGLLKSPLFGEDLKKLKPIINPGGSDSASLDNVLELLVRSGRSLPEAMMMLIPEAWQNNPTMDPELR 313

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770  367 AFYEYHAALMEPWDGPAAVAFTDGRQIGATLDRNGLRPARYIVTSDDRVIMASEAGVLPVAEDKIVKKWRLQPGKMLLID 446
Cdd:cd00713   314 AFYEYHSSLMEPWDGPAAIAFTDGRQVGASLDRNGLRPARYVITKDGLLIMSSEVGVVDVPPEKVVEKGRLGPGEMLLVD 393

                         410       420
                  ....*....|....*....|
gi 503610770  447 MEEGRIISDEEVKSSLAGKH 466
Cdd:cd00713   394 LEEGRILDDEEIKDQLAKRH 413
 
Name Accession Description Interval E-value
gltB PRK11750
glutamate synthase subunit alpha; Provisional
 34-1554 0e+00

glutamate synthase subunit alpha; Provisional


Pssm-ID: 236968 [Multi-domain]  Cd Length: 1485  Bit Score: 1782.50  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770   34 KQGLYDPRNEHDACGVGFVAHLKGEKSHQIVRDGLFMLENLTHRGAVGADPLMGDGAGILVQIPDRFFREEMAKQGVTLP 113
Cdd:PRK11750    2 HMGLYDPSLERDNCGFGLIAHMEGEPSHKLVRTAIHALARMTHRGGIAADGKTGDGCGLLLQKPDRFFRAVAEEAGWRLA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770  114 KagEYAVGYLFMPRDEALIAHFKEVISEVVAEEGQIVLGFRDVPVDNSSLSkapDIA-ATEPHHVQVFIGAGREAaSSDE 192
Cdd:PRK11750   82 K--NYAVGMVFLNQDPELAAAARRILEEELQRETLSVVGWREVPTNPSVLG---EIAlSSLPRIEQVFVNAPAGW-RERD 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770  193 FERRLFTLRKVISNRIYAEADggdlgFYIVSLSTTTIVYKGMFLAYQVGAYYKDLADERFQSAVALVHQRFSTNTFPSWK 272
Cdd:PRK11750  156 FERRLFIARRRIEKRLADDKD-----FYVCSLSNLVIIYKGLMMPADLPRFYLDLADLRLESAICVFHQRFSTNTLPRWP 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770  273 LAHPYRMVAHNGEINTLRGNVNWMAARQASVSSPLFgDDISKLWPISYEGQSDTACFDNALEFLVRGGYSLSHAVMMLIP 352
Cdd:PRK11750  231 LAQPFRYLAHNGEINTITGNRQWARARAYKFQTPLI-PDLQEAAPFVNETGSDSSSLDNMLELLLAGGMDLFRAMRLLVP 309

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770  353 EAWAGNQLMSPERKAFYEYHAALMEPWDGPAAVAFTDGRQIGATLDRNGLRPARYIVTSDDRVIMASEAGVLPVAEDKIV 432
Cdd:PRK11750  310 PAWQNNPDMDPDLRAFYEFNSMHMEPWDGPAGIVMTDGRYAACNLDRNGLRPARYVITKDKLITLASEVGIWDYQPDEVV 389

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770  433 KKWRLQPGKMLLIDMEEGRIISDEEVKSSLAGKHPYRQWLDNTQLILEELKPVEPRALRR----DVSLIDRQQAFGYTHE 508
Cdd:PRK11750  390 EKGRVGPGELLVIDTRTGRILHSAEIDNDLKSRHPYKEWLEKNVRRLVPFEELPDEQVGSreldDDTLKSYQKQFQYSFE 469

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770  509 DTKLLMSPMATTGQEAIGSMGTDTPISAMSDKPKLLYTYFKQNFAQVTNPPIDPIREELVMSLVSFIGPRPNILdHEGMA 588
Cdd:PRK11750  470 ELDQVIRVLAENGQEAVGSMGDDTPMAVLSSQPRSIYDYFRQQFAQVTNPPIDPLREAHVMSLATCIGREMNVF-CETEG 548

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770  589 HAKRLEVRQPILTNGDLEKIRSIGhtEDRFDTKTLDFTYDISRGaeGMLEMLDRLCERAEAAVKGGYNIIVLSDRQIGPD 668
Cdd:PRK11750  549 HAHRVIFKSPVLSYSDFKQLTTLD--EEHYRADTLDLNYDPEET--GLEAAIKRLCDEAEQAVRDGTVLLVLSDRNIAKG 624

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770  669 RVAIPALLATAAVHHHLIRKGLRTSVGLVVESGEPREIHHFCLLAGYGAEAINPYLAFDTLVDMHKRGEFPKEVDEKEVV 748
Cdd:PRK11750  625 RLPIPAAMAVGAVQHRLVDKGLRCDANIIVETASARDPHHFAVLLGFGATAVYPYLAYETLGDLVDTGEILKDYRQVMLN 704

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770  749 YRyiKAVGKGILKVMSKMGISTYQSYCGAQIFDAVGLSSALVGKYFFGTATTIEGIGLEEIAAETVARHKAAFgsdpvLA 828
Cdd:PRK11750  705 YR--KGINKGLYKIMSKMGISTIASYRGSQLFEAVGLHDDVVDLCFKGVVSRIGGASFEDFEQDQKNLSKRAW-----LA 777

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770  829 N-TLDIGGEYAFRMRGESHAWTPDAIASLQHAVR-GNAEDrYREFSAMMNESAsrMNTIRGLFTIKGAEEvgrkPIPIEE 906
Cdd:PRK11750  778 RkPIDQGGLLKYVHGGEYHAYNPDVVNTLQKAVQsGDYSD-YQEYAKLVNERP--VATLRDLLALKPADN----PIPLDE 850

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770  907 VEPAAEIVKRFSTGAMSFGSISREAHTTLAVAMNRIGGKSNTGEGGEESDRYlplpdgstNPER-SAIKQIASGRFGVTT 985
Cdd:PRK11750  851 VEPAEELFKRFDSAAMSIGALSPEAHEALAIAMNRLGGRSNSGEGGEDPARY--------GTEKvSKIKQVASGRFGVTP 922

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770  986 EYLVNADVLQIKVAQGAKPGEGGQLPGHKVDATVAKTRHSTPGVGLISPPPHHDIYSIEDLAQLIYDLKNVNPEADVSVK 1065
Cdd:PRK11750  923 AYLVNAEVLQIKVAQGAKPGEGGQLPGDKVNPLIARLRYSVPGVTLISPPPHHDIYSIEDLAQLIFDLKQVNPKALVSVK 1002

                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770 1066 LVSEVGVGTVAAGVAKARADHITIAGFDGGTGASPLTSLKHAGSPWEIGLAETQQTLVLNGLRSRIALQVDGGLKTGRDV 1145
Cdd:PRK11750 1003 LVSEPGVGTIATGVAKAYADLITISGYDGGTGASPLTSVKYAGSPWELGLAETHQALVANGLRHKIRLQVDGGLKTGLDV 1082

                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770 1146 VIGALLGADEFGFATAPLIAAGCIMMRKCHLNTCPVGVATQDPVLRKR-FKGTPEHVVNYFFFVAEEVREILASLGARRL 1224
Cdd:PRK11750 1083 IKAAILGAESFGFGTGPMVALGCKYLRICHLNNCATGVATQDEKLRKNhYHGLPEMVMNYFEFIAEETREWMAQLGVRSL 1162

                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770 1225 DDIIGSSDLLDR-DRMIEhwKARGLDFSRIFHKVEAPK-EATYWTERQNHPID-DILDRRLIEKAKLALETKVPVAFEAA 1301
Cdd:PRK11750 1163 EDLIGRTDLLEElEGETA--KQQKLDLSPLLETAEPPAgKALYCTEERNPPFDkGLLNEQMLQQAKPAIEAKQGGEFWFD 1240

                        1290      1300      1310      1320      1330      1340      1350      1360
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770 1302 IKNVDRSAGAMLSGALAKRWGHKGLKDDTIHVTLKGTAGQSFGAFLARGITFDLVGDGNDYVGKGLSGGRIIVRPPENAR 1381
Cdd:PRK11750 1241 IRNTDRSVGARLSGEIARRHGNQGMADAPIKLRFTGTAGQSFGVWNAGGLELYLEGDANDYVGKGMAGGKIVIRPPVGSA 1320

                        1370      1380      1390      1400      1410      1420      1430      1440
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770 1382 IVPHQSIIVGNTVLYGAISGECYFNGVAGERFAVRNSGAIAVVEGVGDHGCEYMTGGVVVVLGGTGRNFAAGMSGGVAYV 1461
Cdd:PRK11750 1321 FRSHETAIIGNTCLYGATGGKLFAAGRAGERFAVRNSGAIAVVEGIGDHGCEYMTGGIVCVLGKTGVNFGAGMTGGFAYV 1400

                        1450      1460      1470      1480      1490      1500      1510      1520
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770 1462 LDEEGDFARRCNMAMVELQPVPeeddmleklhhhggdlmhkgmvdvsgDMTRHdEERLYQLISNHLHYTGSVRAKEILDH 1541
Cdd:PRK11750 1401 LDEDGDFVDRVNHELVEILRVE--------------------------DLEIH-REHLRGLITEHVEETGSEWGEEILAN 1453

                        1530
                  ....*....|...
gi 503610770 1542 WADYRPKFRKVMP 1554
Cdd:PRK11750 1454 FDDYLRKFWLVKP 1466
GltB1 COG0067
Glutamate synthase domain 1 [Amino acid transport and metabolism]; Glutamate synthase domain 1 ...
 28-1574 0e+00

Glutamate synthase domain 1 [Amino acid transport and metabolism]; Glutamate synthase domain 1 is part of the Pathway/BioSystem: Glutamine biosynthesis


Pssm-ID: 439837 [Multi-domain]  Cd Length: 1520  Bit Score: 1447.75  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770   28 PSGLPRKQGLYDPRNEHDACGVGFVAHLKGEKSHQIVRDGLFMLENLTHRGAVGADPLMGDGAGILVQIPDRFFREEMAK 107
Cdd:COG0067     4 NSGLPAAQGLYDPAFEHDACGVGFVAHIKGRKSHDIVEDALEALENLEHRGAVGADGKTGDGAGILIQIPDAFFRAEAAE 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770  108 QGVTLPKAGEYAVGYLFMPRDEALIAHFKEVISEVVAEEGQIVLGFRDVPVDNSSLSKApdIAATEPHHVQVFIGAGrEA 187
Cdd:COG0067    84 LGIELPEPGEYAVGMVFLPQDEAARAAARAIIEEILAEEGLTVLGWRDVPVDPSVLGET--ARATEPVIEQVFVARP-DG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770  188 ASSDEFERRLFTLRKVISNRIYAEADGGDlGFYIVSLSTTTIVYKGMFLAYQVGAYYKDLADERFQSAVALVHQRFSTNT 267
Cdd:COG0067   161 LDGDAFERKLYVARKRIEKAIRALGLDDE-DFYICSLSSRTIVYKGMLTPEQLGEFYPDLQDPRFESALALVHQRFSTNT 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770  268 FPSWKLAHPYRMVAHNGEINTLRGNVNWMAARQASVSSPLFGDDISKLWPISYEGQSDTACFDNALEFLVRGGYSLSHAV 347
Cdd:COG0067   240 FPSWPLAQPFRYLAHNGEINTLRGNRNWMRAREALLASPLFGDDLEKLLPIVNPGGSDSASLDNVLELLVLGGRSLPHAM 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770  348 MMLIPEAWAGNQLMSPERKAFYEYHAALMEPWDGPAAVAFTDGRQIGATLDRNGLRPARYIVTSDDRVIMASEAGVLPVA 427
Cdd:COG0067   320 MMLIPEAWENNPDMDPERRAFYEYHSALMEPWDGPAAIVFTDGRQIGATLDRNGLRPARYVVTKDGLVILASEVGVLDIP 399

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770  428 EDKIVKKWRLQPGKMLLIDMEEGRIISDEEVKSSLAGKHPYRQWLDNTQLILEELKPVEPRALRRDVSLIDRQQAFGYTH 507
Cdd:COG0067   400 PEDIVEKGRLQPGKMLLVDLEEGRIIDDEEIKAELAAAHPYGEWLKENRIRLEDLPEPEEEPAPDDDLLLRRQQAFGYTE 479

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770  508 EDTKLLMSPMATTGQEAIGSMGTDTPISAMSDKPKLLYTYFKQNFAQVTNPPIDPIREELVMSLVSFIGPRPNILDHEGM 587
Cdd:COG0067   480 EEELLLLLPMAAGGEEEGGSGGDDDPAALLSSSRLLLYYYFFQFFAQVTNPPPDIIREEVVSSLLTTGGGGNNLLLEEEE 559

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770  588 AHAKRLEVRQPILTNGDLEKIRSIGHTEDRFDTKTLDFTYDISRGAEGMLEMLDRLCERAEAAVKGGYNIIVLSDRQIGP 667
Cdd:COG0067   560 ARRRLLLLPPPLLNELLLLLLRLLDGDFKSTTTITLLDLADGAGGGAAAAAAAAEAAAAAAAAAVLLILIIDLSDDDSDA 639

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770  668 DRVAIPALLATAAVHHHLIRKGLRTSVGLVVESGEPREIHHFCLLAGYGAEAINPYLAFDTLVDMHKRGEfPKEVDEKEV 747
Cdd:COG0067   640 APAPLAAAAAAHHHHLHLLRRRTRLLVVVEVEAVEHHHHHLLLGGGGAAAAAAALYLALELLLDGLLLGL-EDAAAAAAA 718

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770  748 VYRYIKAVGKGILKVMSKMGISTYQSYCGAQIFDAVGLSSALVGKYFFGTATTIEGIGLEEIAAETVARHKAAFGSDPVL 827
Cdd:COG0067   719 KKKKKKKKGKLKKKKMSGIISSSSGSYGAAAIFGALGLVVVVFFTFTTTTGGGGGGGGLDEEAEEEAARAAAAAAEPGGL 798

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770  828 ANTLDIGGEYAFRMRGESHAWTPDAIASLQHAVRGNAEDRYREFSAMMNESASRMNTIRGLFTIKGAEEVgrkPIPIEEV 907
Cdd:COG0067   799 LLGLGGGGGGEYGRRREGELHLLLQAATAAAAAAYRAYKYYRFARYTALLDLLRLLLLLLLLLFEEEEEE---EEPEEEE 875

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770  908 EPAAEIVKRFSTGAMSFGSISREAHTTLAVAMNRIGGKSNTGEGGEESDRylplpdGSTNPERSAIKQIASGRFGVTTEY 987
Cdd:COG0067   876 EEEESSAIAAASSAAASAAASAAAAAAAAGAGGGGGGGGGGGGGGGEGRR------ASGGSGSSSSASVAAAGGGVVVGA 949

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770  988 LVNADVLQIKVAQGAKPGEGGQLPGHKVDATVAKTRHSTPGVGLISPPPHHDIYSIEDLAQLIYDLKNVNPEADVSVKLV 1067
Cdd:COG0067   950 GAAAAEGGGGGGGGGGGGGGGGGGGGGGVPGIAPPPPHPPPPGIILPPPPHDIIIIIILLLLILLLLALVAVAAAVAVVV 1029

                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770 1068 SEVGVGTVAAGVAKARADHITIAGFDGGTGASPLTSLKHAGSPWEIGLAETQQTLVLNGLRSRIALQVDGGLKTGRDVVI 1147
Cdd:COG0067  1030 VAAAAGVAAAAAAAAAAAAVGSSGGGGGGGGGGGGSGAAGALGALGLLGLLLLLLLLLLLLLLGVVVLGGLGGGGGGGGG 1109

                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770 1148 GALLGADEFGFATAPLIAAGCIMMRKCHLNTCPVGVATQDPVLRKRFKGTPEHVVNYFFFVAEEVREILASLGARRLDDI 1227
Cdd:COG0067  1110 AAALGAGALGGGAAALVVVGCGVAMCCVVLLCTVGGAAAGELERRRFRFAGEEVVVEEFFEAAEEEEEEALLELLRLLEE 1189

                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770 1228 IGSSDLLDRDRMIEHWKARGLDFSRIFHKVEAPKEATYWTERQNHPIDDILDRRLI--EKAKLALETKVPVAFEAAIKNV 1305
Cdd:COG0067  1190 GLGVVELLLLLLLLLLLAKLLLLLLLLLLPLLPPDDPRDLALEEDDELLLLLALLLllLALALALLAAVRVALRAALGRA 1269

                        1290      1300      1310      1320      1330      1340      1350      1360
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770 1306 DRSAGAMLSGALAKRWGHKGLKDDTIHVTLKGTAGQSFGAFLARGITFDLVGDGNDYVGKGLSGGRIIVRPPENARIVPH 1385
Cdd:COG0067  1270 RRRGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGG 1349

                        1370      1380      1390      1400      1410      1420      1430      1440
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770 1386 QSIIVGNTVLYGAISGECYFNGVAGERFAVRNSGAIAVVEGVGDHGCEYMTGGVVVVLGGTGRNFAAGMSGGVAYVLDEE 1465
Cdd:COG0067  1350 GGGGGGGAGGGGGGGGGAGGGGGGGGGGVGGGGGGGGVGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGLDL 1429

                        1450      1460      1470      1480      1490      1500      1510      1520
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770 1466 GDFARRCNMAMVELQPVPEEDDMLEKLHHHGGdlmhkgmvdvsgdmtrhdeerlyqlisnHLHYTGSVRAKEILDHWADY 1545
Cdd:COG0067  1430 DVVLDEEEEEELEELLLLLEEEEEEELELEEE----------------------------EAELLELADAALLLLLLVKV 1481

                        1530      1540
                  ....*....|....*....|....*....
gi 503610770 1546 RPKFRKVMPVEYRRALEDMERMKMAEAAE 1574
Cdd:COG0067  1482 KAAVKVLLLLLLAAAAAAAEAAAAAAAAA 1510
GltB3 COG0070
Glutamate synthase domain 3 [Amino acid transport and metabolism]; Glutamate synthase domain 3 ...
 33-1574 0e+00

Glutamate synthase domain 3 [Amino acid transport and metabolism]; Glutamate synthase domain 3 is part of the Pathway/BioSystem: Glutamine biosynthesis


Pssm-ID: 439840 [Multi-domain]  Cd Length: 1508  Bit Score: 1417.75  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770   33 RKQGLYDPRNEHDACGVGFVAHLKGEKSHQIVRDGLFMLENLTHRGAVGADPLMGDGAGILVQIPDRFFREEMAKQGVTL 112
Cdd:COG0070     1 GGGAGAMGAAAAAGGGGGGGGAGGDGLGGGGGGAAALGGGLGALAAAGAAGGAGAGGGGAGAGGGTGGGGGGGGGGGGGG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770  113 PKAGEYAVGYLFMPRDEALIAHFKEVISEVVAEEGQIVLGFRDVPVDNSSLSKAPDIAATEPHHVQVFIGAGREAASSDE 192
Cdd:COG0070    81 GLGALLAGGGAFFAAGLAAGLLALAAAVEAEAEEAEEDEEEEERVLLLVLLEAETLVVLLALGVRAAALARREAELSELA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770  193 FERRLFTLRKVISNRIYAEADGGDLGFYIVSLSTTTIVYKGMFLAYQVGAYYKDLADERFQSAVALVHQRFSTNTFPSWK 272
Cdd:COG0070   161 ARRRLRLRRLALLRRRRRRRRREFRRRSSSSLSSSSSSLYSLLLLVLLLLLLLLLLLLLLLLLFLSFLSRFTTTTTSSLT 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770  273 LAHPYRMVAHNGEINTLRGNVNWMAARQASVSSPLFGDDISKLWPISYEGQSDTACFDNALEFLVRGGYSLSHAVMMLIP 352
Cdd:COG0070   241 LFFAPRTLAANNNNNNNNNNNNNNNRNAILNLSSRLEALSLELLPPLLPLLSDSSSDDLLLLLLLLLLLLLLLLLLMALA 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770  353 EAWAGNQLMSPERKAFYEYHAALMEPWDGPAAVAFTDGRQIGATLDRNGLRPARYIVTSDDRVIMASEAGVLPVAEDKIV 432
Cdd:COG0070   321 AAAPAPRAAAPPAAAAAFAAAADLYAAAAAAAAAAAGGDGDGGGLGLGGGRRRRRRLLRDRRLVRALSILVGLLILIEVV 400

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770  433 KKWRLQPGKMLLIDMEEGRIISDEEVKSSLAGKHPYRQWLDNTQLILEELKPvEPRALRRDVSLIDRQQAFGYTHEDTKL 512
Cdd:COG0070   401 GKGRELPGGGLLVGGGGGGLLDDEEEDAEELEELLPELQDLLLLLKLLLLLE-EEEELLLLEEELLQEREAELEQELLLL 479

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770  513 LMSPMATTGQEAIGSMGTDTPISAMSDKPKLLYTYFKQNFAQVTNPPIDPIREELVMSLVSFIGPRPNILDHEGMAHAKR 592
Cdd:COG0070   480 LLLLLAEALEEEEESGGAGAAAAALDLLDLLLLLDFQFLLLFFQQPPPPVVFPPIVLLLEPPPLLLLLLLLLLLLLLEEL 559

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770  593 LEVRQPILTNGDLEKIRSIGHTEDRFDTKTLDFTYDISRGAEGMLEMLDRLCERAEAAVKGGYNIIVLSDRQIGPDRVAI 672
Cdd:COG0070   560 LLLELLLLLLALALLLLLLLLLLLLGDATTLAAALEAAGGGGALAALLLAAEAAAAAAAAAVAAILAASIRDSALLLALL 639

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770  673 PALLATAAVHHHLIRKGLRTSVGLVVESGEPREIHHFCLLAGYGAEAINPYLAFDTLVDMHKRGEfpKEVDEKEVVYRYI 752
Cdd:COG0070   640 PALLALLLLHHHLLRALGRVLVLLVEALLRERVVHVAALLAGAAAAAAAALAALAAAAALLLLAY--ALLGLLEAAAYKA 717

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770  753 KAVGKGILKVMSKMGISTYQSYCGAQIFDAVGLSSALVGKYFFGTATTIEGIGLEEIAAETVARHKAAFGSDPVLANTLD 832
Cdd:COG0070   718 KAALKAGVKKKLKIGGSSISSSSGGGIIEGAGGGLGLLLELGGTTTTVGEGGGGGEILGEGGAARHAAAADAAAAAALAL 797

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770  833 IGGEYAFRMRGESHAWTPDAIASLQHAVRGNAEDRYREFSAMMNESASRMNTIRGLFTIKGaeevGRKPIPIEEVEPAAE 912
Cdd:COG0070   798 GGGGGGGRGGGGEGHHGGHYHHLLQQLAARTAAALYDDYYAYEDRADELVNERLRLLLLFL----LRPPIPIEEVEPEEE 873

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770  913 IVKRFSTGAMSFGSISREAHTTLAVAMNRIGGKSNTGEGGEESDRYLPLPDGSTNpeRSAIKQIASGRFGVTTEYLVNAD 992
Cdd:COG0070   874 IVKRFATGAMSGGSSSSEAHEELAIAMNRIGGKSNGGGGGEEEGREDPLRNGDSR--RSAIKQVASGRFGVTSEYLVNAD 951

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770  993 VLQIKVAQGAKPGEGGQLPGHKVDATVAKTRHSTPGVGLISPPPHHDIYSIEDLAQLIYDLKNVNPEADVSVKLVSEVGV 1072
Cdd:COG0070   952 EIQIKMAQGAKPGEGGQLPGHKVYPWIARLRHSTPGVGLISPPPHHDIYSIEDLAQLIFDLKNANPAARISVKLVSEVGV 1031

                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770 1073 GTVAAGVAKARADHITIAGFDGGTGASPLTSLKHAGSPWEIGLAETQQTLVLNGLRSRIALQVDGGLKTGRDVVIGALLG 1152
Cdd:COG0070  1032 GTIAAGVAKAAADVILISGHDGGTGASPLSSIKHAGLPWELGLAETQQTLVLNNLRRRVVVQTDGGLKTGRDVVIAALLG 1111

                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770 1153 ADEFGFATAPLIAAGCIMMRKCHLNTCPVGVATQDPVLRKRFKGTPEHVVNYFFFVAEEVREILASLGARRLDDIIGSSD 1232
Cdd:COG0070  1112 AEEFGFATAPLVVLGCIMMRKCHLNTCPVGVATQDPELRKRFFGGPEHVVNFFFFFAEEVRELMAALGGRTLDEEIGRRD 1191

                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770 1233 LLDRDRMIEHWKARGLDFSRIFHKVEAPKE-ATYWTERQNHPIDDILDRRLIEKAKLALETKVPVAFEAAIKNVDRSAGA 1311
Cdd:COG0070  1192 LLLVRRAVDHWKAKGLDLSPLLYKPDVPADvPRYCTEEQNHGLEGALDRELIEDARPAIENGEPVELEYPIRNTDRSVGT 1271

                        1290      1300      1310      1320      1330      1340      1350      1360
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770 1312 MLSGALAKRWGHKGLKDDTIHVTLKGTAGQSFGAFLARGITFDLVGDGNDYVGKGLSGGRIIVRPPENARIVPHQSIIVG 1391
Cdd:COG0070  1272 RLSGEIAKRYGNEGLPEDTITLRFTGSAGQSFGAFLAKGLTLELEGDANDYVGKGLSGGKIIVRPPAGSTFVAEENIIIG 1351

                        1370      1380      1390      1400      1410      1420      1430      1440
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770 1392 NTVLYGAISGECYFNGVAGERFAVRNSGAIAVVEGVGDHGCEYMtggvvvvlggtgRNFAAGMSGGVAYVLDEEGDFARR 1471
Cdd:COG0070  1352 NTCLYGATGGELYAAGRAGERFAVRNSGATAVVEGVGDHGCEYMtggvvvvlgptgRNFGAGMSGGIAYVLDEDGDFEDR 1431

                        1450      1460      1470      1480      1490      1500      1510      1520
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770 1472 CNMAMVELQPVPEEddmleklhhhggdlmhkgmvdvsgdmtrHDEERLYQLISNHLHYTGSVRAKEILDHWADYRPKFRK 1551
Cdd:COG0070  1432 CNPEMVELERLDEE----------------------------EDEEELRELIEEHVEYTGSARAKEILDNWDEYLPKFVK 1483

                        1530      1540
                  ....*....|....*....|...
gi 503610770 1552 VMPVEYRRALEDMERMKMAEAAE 1574
Cdd:COG0070  1484 VMPKDYKRVLEAIAEAEAAGLDA 1506
GltB2 COG0069
Glutamate synthase domain 2 [Amino acid transport and metabolism]; Glutamate synthase domain 2 ...
 676-1416 0e+00

Glutamate synthase domain 2 [Amino acid transport and metabolism]; Glutamate synthase domain 2 is part of the Pathway/BioSystem: Glutamine biosynthesis


Pssm-ID: 439839  Cd Length: 728  Bit Score: 1014.79  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770  676 LATAAVHHHLIRKGLRTSVGLVVESGEPREIHHFCLLAGYGAEAINPYLAFDTLVDMHKRGefPKEVDEKEVVYRYIKAV 755
Cdd:COG0069     1 LAAAAHHHLLRRKGRRTVSLIVVEGEERRVHHHAALLGGGGAAANPPYLAEEILDLLRRGG--LLGLDLEEAVKNYIKAI 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770  756 GKGILKVMSKMGISTYQSYCGAQIFDAVGLSSALVGkyffgtattiegIGLEEIAAetvaRHKAAFgsdpvlANTLDIGG 835
Cdd:COG0069    79 EKGLLKIMSKMGISTLASYRGAQIFEAVGLSRELVD------------IGIADVLT----QHRHAI------LRNLPVGG 136

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770  836 EYAFR--------------MRGESHAWTPDAIASLQHAVRGnaEDRYREFSAMMNESASRMNTIRGLFTIKgaeeVGRKP 901
Cdd:COG0069   137 RYRYRfesigpeirqyffeSDGEEHPFNRETRSLLYQAAKN--EEDYKPFGTLVDYQPGYEWTLRSLFPFK----ADRPP 210

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770  902 IPIEE-VEPAAEIVKRFSTGAMSFGSISREAHTTLAVAMNRIGGKSNTGEGGEESDRYlplpdgsTNPERSAIKQIASGR 980
Cdd:COG0069   211 IPIGEpVEPPYSIVSRFNISAMSFGALSAEAHEALAIGMNRIGGKSNTGEGGESPYHL-------GDGGGDAIKQIASGR 283

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770  981 FGVTT---EYLVNADVLQIKVAQGAKPGEGGQLPGHKVDATVAKTRHSTPGVGLISPPPHHDIYSIEDLAQLIYDLKNVN 1057
Cdd:COG0069   284 FGVRDedgEYLPNAKMIEIKLAQGAKPGEGGQLPGAKVTPEIARIRGSTPGVDLISPPPHHDIYSIEDLAQLIFDLRELN 363

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770 1058 PEADVSVKLVSEVGVGTVAA--GVAK--ARADHITIAGFDGGTGASPLTSLKHAGSPWEIGLAETQQTLVLNGLRSRIAL 1133
Cdd:COG0069   364 PGAPVGVKLVSGAGVGTIAAckGVAKtgAYADFITIDGGEGGTGAAPLESIKHAGLPWELGLAEVHQTLVGNGLRDRIRL 443

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770 1134 QVDGGLKTGRDVVIGALLGADEFGFATAPLIAAGCIMMRKCHLNTCPVGVATQDPVLRKRFK--GTPEHVVNYFFFVAEE 1211
Cdd:COG0069   444 IADGKLKTGRDVAIAAALGADEFGFARAFMVALGCIMARKCHLNTCPVGVATQDPELRKGFVveGKPERVVNYFRFTAEE 523

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770 1212 VREILASLGARRLDDIIGSSDLLdRDRMIEHWKARGLDFSRIFHKVEAPK-EATYWTERQNHPIDDILDRRLIEKAKLAL 1290
Cdd:COG0069   524 VREILAALGVRSPDELIGRHDLL-RVRDGEHWKAKGLDLSPLLYKPELPEgVPRRCQEEQDHGLDKALDLELIAAAAAAA 602

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770 1291 ETKVPVAFEAAIKNVDRSAGAMLSGALAKRWGHKGLKDDTIHVTLKGTAGQSFGAFLARGITFDLVGDGNDYVGKGLSGG 1370
Cdd:COG0069   603 EEGKPVVLITNIRNNNRRVGGMLSGEIAKRYGGAGLPDDTIILGFAGGAGQSFGAFGAGGGLLLLEGDDNDYVGKGGGGG 682

                         730       740       750       760
                  ....*....|....*....|....*....|....*....|....*.
gi 503610770 1371 RIIVRPPENARIVPHQSIIVGNTVLYGAISGECYFNGVAGERFAVR 1416
Cdd:COG0069   683 GIIVPPPPGASFFPEENIIIGNTGLYGATGGGAYFAGGAGERFAVR 728
GATase_2 pfam00310
Glutamine amidotransferases class-II;
47-471 0e+00

Glutamine amidotransferases class-II;


Pssm-ID: 395245 [Multi-domain]  Cd Length: 420  Bit Score: 759.82  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770    47 CGVGFVAHLKGEKSHQIVRDGLFMLENLTHRGAVGADPLMGDGAGILVQIPDRFFREEMAKQGVTLPKAGEYAVGYLFMP 126
Cdd:pfam00310    1 CGVGFIAHIKGKPSHKIVEDALEALENMEHRGACGADPDTGDGAGILTQIPDEFFRKEAKELGIELPEAGQYAVGMVFLP 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770   127 RDEALIAHFKEVISEVVAEEGQIVLGFRDVPVDNSSLSKAPdiAATEPHHVQVFIGAGrEAASSDEFERRLFTLRKVISN 206
Cdd:pfam00310   81 QDEAKRAEAKKIFEEIAEEEGLEVLGWREVPTNNSVLGEAA--LESEPQIEQVFVGSP-AGKSEDDFERKLYVARKRIEK 157

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770   207 RIYAEADGGDlgFYIVSLSTTTIVYKGMFLAYQVGAYYKDLADERFQSAVALVHQRFSTNTFPSWKLAHPYRMVAHNGEI 286
Cdd:pfam00310  158 EIGVEGGDKD--FYICSLSSRTIVYKGMLTPEQLGQFYLDLQDPRFESAFALVHSRFSTNTFPSWPLAQPMRFLAHNGEI 235

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770   287 NTLRGNVNWMAARQASVSSPLFGDDISKLWPISYEGQSDTACFDNALEFLVRGGYSLSHAVMMLIPEAWAGNQLMSPERK 366
Cdd:pfam00310  236 NTLRGNRNWMRAREALLKSELFGDDLDKLLPIVNPGGSDSASLDNVLELLVLGGRSLPEALMMLIPEAWQNNPSMDPEKR 315

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770   367 AFYEYHAALMEPWDGPAAVAFTDGRQIGATLDRNGLRPARYIVTSDDRVIMASEAGVLPVAEDKIVKKWRLQPGKMLLID 446
Cdd:pfam00310  316 AFYEYHSGLMEPWDGPALIVFTDGRYVGATLDRNGLRPARYYITKDGLIILASEVGVLDIPPERVVEKGRLGPGRMLLVD 395

                          410       420
                   ....*....|....*....|....*
gi 503610770   447 MEEGRIISDEEVKSSLAGKHPYRQW 471
Cdd:pfam00310  396 LEEGRIIDDEEIKQQIASRHPYGEW 420
GltS cd00713
Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a ...
 47-466 0e+00

Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The N-terminal glutaminase domain catalyzes the hydrolysis of glutamine to glutamic acid and ammonia, and has a fold similar to that of other glutamine amidotransferases such as glucosamine-fructose 6-phosphate synthase (GLMS or GFAT), glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase), asparagine synthetase B (AsnB), and beta lactam synthetase (beta-LS), as well as the Ntn hydrolase folds of the proteasomal alpha and beta subunits.


Pssm-ID: 238365 [Multi-domain]  Cd Length: 413  Bit Score: 724.70  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770   47 CGVGFVAHLKGEKSHQIVRDGLFMLENLTHRGAVGADPLMGDGAGILVQIPDRFFREEMAKQGVTLPKAGEYAVGYLFMP 126
Cdd:cd00713     1 CGVGFVANIDGKPSHDIVQDALEALERMEHRGGVGADGKTGDGAGILIQIPHEFFREELAEAGIELPEAGEYAVGMLFLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770  127 RDEALIAHFKEVISEVVAEEGQIVLGFRDVPVDNSSLSkaPDIAATEPHHVQVFIGAgREAASSDEFERRLFTLRKVISN 206
Cdd:cd00713    81 RDEEAREAAKAIIEEELEAEGLRVLGWRDVPVDNSVLG--PTARATEPLIEQVFVGA-PSGDDGEAFERKLYLLRKRIEK 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770  207 RIYAEADGgdlgFYIVSLSTTTIVYKGMFLAYQVGAYYKDLADERFQSAVALVHQRFSTNTFPSWKLAHPYRMVAHNGEI 286
Cdd:cd00713   158 AIRAADED----FYVCSLSSRTIVYKGMLLPEQLGQFYPDLQDPRFESAFALVHSRFSTNTFPSWPLAQPFRYLAHNGEI 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770  287 NTLRGNVNWMAARQASVSSPLFGDDISKLWPISYEGQSDTACFDNALEFLVRGGYSLSHAVMMLIPEAWAGNQLMSPERK 366
Cdd:cd00713   234 NTIRGNRNWMRAREGLLKSPLFGEDLKKLKPIINPGGSDSASLDNVLELLVRSGRSLPEAMMMLIPEAWQNNPTMDPELR 313

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770  367 AFYEYHAALMEPWDGPAAVAFTDGRQIGATLDRNGLRPARYIVTSDDRVIMASEAGVLPVAEDKIVKKWRLQPGKMLLID 446
Cdd:cd00713   314 AFYEYHSSLMEPWDGPAAIAFTDGRQVGASLDRNGLRPARYVITKDGLLIMSSEVGVVDVPPEKVVEKGRLGPGEMLLVD 393

                         410       420
                  ....*....|....*....|
gi 503610770  447 MEEGRIISDEEVKSSLAGKH 466
Cdd:cd00713   394 LEEGRILDDEEIKDQLAKRH 413
Glu_synthase pfam01645
Conserved region in glutamate synthase; This family represents a region of the glutamate ...
 846-1222 0e+00

Conserved region in glutamate synthase; This family represents a region of the glutamate synthase protein. This region is expressed as a separate subunit in the glutamate synthase alpha subunit from archaebacteria, or part of a large multidomain enzyme in other organizms. The aligned region of these proteins contains a putative FMN binding site and Fe-S cluster.


Pssm-ID: 396287 [Multi-domain]  Cd Length: 367  Bit Score: 572.74  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770   846 HAWTPDAIASLQHAVRGNAEDRYREFSAMMNEsASRMNTIRGLFTIKGAEEvgrkPIPIEEVEPAAEIVKRFSTGAMSFG 925
Cdd:pfam01645    1 HRNEPEFIKTLQIAVQVESYPSYDKYREPLNE-RVPIGALRDLLEFDFAED----PIPLEEVEPALEIKTRFCTGAMSYG 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770   926 SISREAHTTLAVAMNRIGGKSNTGEGGEESDRYLPLPDGstnpersAIKQIASGRFGVTTEYLVNADVLQIKVAQGAKPG 1005
Cdd:pfam01645   76 ALSEEAHEALAKAMNRLGTKSNTGEGGEDPERLKYADNI-------AIKQVASGRFGVTPEYLNNADAIEIKIAQGAKPG 148

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770  1006 EGGQLPGHKVDATVAKTRHSTPGVGLISPPPHHDIYSIEDLAQLIYDLKNVNPEADVSVKLVSEVGVGTVAAGVAKARAD 1085
Cdd:pfam01645  149 EGGHLPGEKVSPEIARIRGSPPGVGLISPPPHHDIYSIEDLAQLIYDLKEINPKAPISVKLVSGHGVGTIAAGVAKAGAD 228

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770  1086 HITIAGFDGGTGASPLTSLKHAGSPWEIGLAETQQTLVLNGLRSRIALQVDGGLKTGRDVVIGALLGADEFGFATAPLIA 1165
Cdd:pfam01645  229 IILIDGYDGGTGASPKTSIKHAGLPWELALAEAHQTLKENGLRDRVSLIADGGLRTGADVAKAAALGADAVYIGTAALIA 308

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 503610770  1166 AGCIMMRKCHLNTCPVGVATQDPVLRKR--FKGTPEHVVNYFFFVAEEVREILASLGAR 1222
Cdd:pfam01645  309 LGCIMCRVCHTNTCPVGVATQDPELRKRldFEGAPERVVNYFRFLAEEVRELLAALGIN 367
GltS_FMN cd02808
Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that ...
 850-1236 1.48e-171

Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast and bacterial pathway for ammonia assimilation. It is a multifunctional enzyme that functions through three distinct active centers, carrying out L-glutamine hydrolysis, conversion of 2-oxoglutarate into L-glutamate, and electron uptake from an electron donor.


Pssm-ID: 239202 [Multi-domain]  Cd Length: 392  Bit Score: 520.56  E-value: 1.48e-171
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770  850 PDAIASLQHAVRG--NAEDRYREFSAMMNESASRMNTIRGLFTIK---------GAEEVGRKPIPIEEVEPAAEIVKRFS 918
Cdd:cd02808     2 LLEIERLEEIQYFvfNRAERYGVYNRAGNSRGRPFGTLRDLLEFGaqlakhplePDEEVDDRVTIGPNAEKPLKLDSPFN 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770  919 TGAMSFGSISREAHTTLAVAMNRIGGKSNTGEGGEESDRYLPlpdgstnpERSAIKQIASGRFGVTTEYLVNADVLQIKV 998
Cdd:cd02808    82 ISAMSFGALSKEAKEALAIGAALAGTASNTGEGGELPEEREG--------GGDIIKQVASGRFGVRPEYLNKADAIEIKI 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770  999 AQGAKPGEGGQLPGHKVDATVAKTRHSTPGVGLISPPPHHDIYSIEDLAQLIYDLKNVNPEADVSVKLVSEVGVGTVAAG 1078
Cdd:cd02808   154 GQGAKPGEGGHLPGEKVTEEIAKIRGIPPGVDLISPPPHHDIYSIEDLAQLIEDLREATGGKPIGVKLVAGHGEGDIAAG 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770 1079 VAKARADHITIAGFDGGTGASPLTSLKHAGSPWEIGLAETQQTLVLNGLRSRIALQVDGGLKTGRDVVIGALLGADEFGF 1158
Cdd:cd02808   234 VAAAGADFITIDGAEGGTGAAPLTFIDHVGLPTELGLARAHQALVKNGLRDRVSLIASGGLRTGADVAKALALGADAVGI 313

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770 1159 ATAPLIAAGCIMMRKCHLNTCPVGVATQDPVLRKR--FKGTPEHVVNYFFFVAEEVREILASLGARRLDDiIGSSDLLDR 1236
Cdd:cd02808   314 GTAALIALGCIQARKCHTNTCPVGVATQDPELRRRldVEGKAERVANYLKSLAEELRELAAALGKRSLEL-LGRSDLLAL 392
Glu_syn_central pfam04898
Glutamate synthase central domain; The central domain of glutamate synthase connects the amino ...
 498-786 1.20e-170

Glutamate synthase central domain; The central domain of glutamate synthase connects the amino terminal amidotransferase domain with the FMN-binding domain and has an alpha / beta overall topology. This domain appears to be a rudimentary form of the FMN-binding TIM barrel according to SCOP.


Pssm-ID: 461469 [Multi-domain]  Cd Length: 281  Bit Score: 513.85  E-value: 1.20e-170
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770   498 DRQQAFGYTHEDTKLLMSPMATTGQEAIGSMGTDTPISAMSDKPKLLYTYFKQNFAQVTNPPIDPIREELVMSLVSFIGP 577
Cdd:pfam04898    1 RRQKAFGYTQEDLEMLLKPMAETGKEPIGSMGDDTPLAVLSDKPRLLYDYFKQLFAQVTNPPIDPIREEIVMSLRTYLGP 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770   578 RPNILDhEGMAHAKRLEVRQPILTNGDLEKIRSIGHteDRFDTKTLDFTYDisrgaeGMLEMLDRLCERAEAAVKGGYNI 657
Cdd:pfam04898   81 EGNLLE-ETPEHCRRLELPSPILTNEELEKLRSLKG--PGFKVATLDITFD------GLEAALERLCEEAEEAVRDGANI 151

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770   658 IVLSDRQIGPDRVAIPALLATAAVHHHLIRKGLRTSVGLVVESGEPREIHHFCLLAGYGAEAINPYLAFDTLVDMHKRGE 737
Cdd:pfam04898  152 LILSDRGVDADRAPIPSLLAVSAVHHHLVREGLRTKVSLVVESGEAREVHHFAVLLGYGADAVNPYLAFETIRDLIREGK 231

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|
gi 503610770   738 FPK-EVDEKEVVYRYIKAVGKGILKVMSKMGISTYQSYCGAQIFDAVGLS 786
Cdd:pfam04898  232 GKLtDEDLEEAVKNYRKAIEKGLLKIMSKMGISTLQSYRGAQIFEAIGLS 281
gltB_C cd00982
gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate ...
 1278-1554 1.25e-133

gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the transfer of ammonia and electrons among three distinct active centers that carry out L-Gln hydrolysis, conversion of 2-oxoglutarate into L-Glu, and electron uptake from a donor. These catalytic sites appear to occur in other domains within the protein, and not the domain in this CD. This particular domain has no known function, but it likely has a structural role as it interacts with the amidotransferase and FMN-binding domains of gltS.


Pssm-ID: 238482 [Multi-domain]  Cd Length: 251  Bit Score: 413.46  E-value: 1.25e-133
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770 1278 LDRRLIEKAKLAL-ETKVPVAFEAAIKNVDRSAGAMLSGALAKRWGHKGLKDDTIHVTLKGTAGQSFGAFLARGITFDLV 1356
Cdd:cd00982     1 LDDKLIADAEPALiENGEPVTLEYPIRNTDRAVGTMLSGEIAKRYGEEGLPEDTIKIKFEGSAGQSFGAFLAKGVTLELE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770 1357 GDGNDYVGKGLSGGRIIVRPPENARIVPHQSIIVGNTVLYGAISGECYFNGVAGERFAVRNSGAIAVVEGVGDHGCEYMT 1436
Cdd:cd00982    81 GDANDYVGKGLSGGRIVVRPPKDATFKPEENIIIGNVCLYGATSGEAFIRGRAGERFAVRNSGATAVVEGVGDHGCEYMT 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770 1437 GGVVVVLGGTGRNFAAGMSGGVAYVLDEEGDFARRCNMAMVELQPVPEEddmleklhhhggdlmhkgmvdvsgdmtrHDE 1516
Cdd:cd00982   161 GGTVVVLGKTGRNFAAGMSGGVAYVLDEDGDFEKKVNHEMVDLERLEDA----------------------------EDE 212

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 503610770 1517 ERLYQLISNHLHYTGSVRAKEILDHWADYRPKFRKVMP 1554
Cdd:cd00982   213 EQLKELIEEHVEYTGSEKAKEILANWEAYLKKFVKVIP 250
GXGXG pfam01493
GXGXG motif; This domain is found in glutamate synthase, tungsten formylmethanofuran ...
 1301-1487 9.74e-103

GXGXG motif; This domain is found in glutamate synthase, tungsten formylmethanofuran dehydrogenase subunit c (FwdC) and molybdenum formylmethanofuran dehydrogenase subunit c (FmdC). A repeated G-XX-G-XXX-G motif is seen in the alignment.


Pssm-ID: 460231 [Multi-domain]  Cd Length: 190  Bit Score: 325.91  E-value: 9.74e-103
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770  1301 AIKNVDRSAGAMLSGALAKRWGHKGLKDDTIHVTLKGTAGQSFGAFLARGITFDLVGDGNDYVGKGLSGGRIIVRPPENA 1380
Cdd:pfam01493    2 EIRNTDRSVGTILSGEIAKRYGEDGLPDDTITIKFNGSAGQSFGAFLPKGLTLELEGDANDYVGKGLSGGKIIIYPPAES 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770  1381 RIVPHQSIIVGNTVLYGAISGECYFNGVAGERFAVRNSGAIAVVEGVGDHGCEYMTGGVVVVLGGTGRNFAAGMSGGVAY 1460
Cdd:pfam01493   82 TFKAEENIIIGNTCLYGATGGELFINGRAGERFAVRNSGATAVVEGVGDHGCEYMTGGRVVVLGKTGRNFGAGMSGGIAY 161

                          170       180
                   ....*....|....*....|....*..
gi 503610770  1461 VLDEEGDFARRCNMAMVELQPVPEEDD 1487
Cdd:pfam01493  162 VLDEDGDFPEKLNKEMVELERVTDEDE 188
GXGXG cd00504
GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit ...
 1307-1463 4.89e-53

GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran dehydrogenase (FmdC). It is also found in a primarily archeal group of proteins predicted to encode part of the large subunit of GltS. It is characterized by a repeated GXXGXXXG motif. GltS is a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the transfer of ammonia and electrons among three distinct active centers that carry out L-Gln hydrolysis, conversion of 2-oxoglutarate into L-Glu, and electron uptake from a donor. These catalytic sites occur in other domains within the protein or or encoded by separate genes, and are not present in the domain in this CD. FwdC and FmdC are reversible ion pumps that catalyze the formylation and deformylation of methanofuran in hyperthermophiles and bacteria. They require the presence of either tungstun (FwdC) or molybdenum (FmdC). The specific function of this domain also remains unidentified in the formylmethanofuran dehydrogenases.


Pssm-ID: 238281 [Multi-domain]  Cd Length: 149  Bit Score: 182.77  E-value: 4.89e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770 1307 RSAGAMLSGALAKRwghKGLKDDTIHVTLKGTAGQSFGAFLArGITFDLVGDGNDYVGKGLSGGRIIVRPPENarivpHQ 1386
Cdd:cd00504     1 RAVGTRGSRYIGKR---PGLPEDTVEIIINGSAGQSFGAFMA-GGTITVEGNANDYVGKGMSGGEIVIHPPAG-----DE 71

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 503610770 1387 SIIVGNTVLYGAISGECYFNGVAGERFAVRNSGAIAVVEGVGD-HGCEYMTGGVVVVLGGTGRNFAAGMSGGVAYVLD 1463
Cdd:cd00504    72 NGIAGNVALYGATGGKIFVRGNAGERFGVRMSGGTIVVEGVGDdFGGEYMTGGTIVVLGDAGRNFGAGMSGGVIYVRG 149
Gn_AT_II cd00352
Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide ...
 240-443 2.34e-38

Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to members of the Ntn (N-terminal nucleophile) hydrolase superfamily and is found at the N-terminus of enzymes such as glucosamine-fructose 6-phosphate synthase (GLMS or GFAT), glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase), asparagine synthetase B (AsnB), beta lactam synthetase (beta-LS) and glutamate synthase (GltS). GLMS catalyzes the formation of glucosamine 6-phosphate from fructose 6-phosphate and glutamine in amino sugar synthesis. GPATase catalyzes the first step in purine biosynthesis, an amide transfer from glutamine to PRPP, resulting in phosphoribosylamine, pyrophosphate and glutamate. Asparagine synthetase B synthesizes asparagine from aspartate and glutamine. Beta-LS catalyzes the formation of the beta-lactam ring in the beta-lactamase inhibitor clavulanic acid. GltS synthesizes L-glutamate from 2-oxoglutarate and L-glutamine. These enzymes are generally dimers, but GPATase also exists as a homotetramer.


Pssm-ID: 238212 [Multi-domain]  Cd Length: 220  Bit Score: 143.36  E-value: 2.34e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770  240 VGAYYKDLADERFQSAVALVHQRFSTNTFPSWKLAHPYR------MVAHNGEINTLRGNVNWMAARqasvssplfgddis 313
Cdd:cd00352    54 VSDVALDLLDEPLKSGVALGHVRLATNGLPSEANAQPFRsedgriALVHNGEIYNYRELREELEAR-------------- 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770  314 klwPISYEGQSDTACFDNALEFLVRGGYsLSHAVMMLIPEawagnqlmsperkafyeyhaalmepWDGPAAVAFTDG--R 391
Cdd:cd00352   120 ---GYRFEGESDSEVILHLLERLGREGG-LFEAVEDALKR-------------------------LDGPFAFALWDGkpD 170

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 503610770  392 QIGATLDRNGLRPARYIVTSDDRVIMASEAGVLpvAEDKIVKKWRLQPGKML 443
Cdd:cd00352   171 RLFAARDRFGIRPLYYGITKDGGLVFASEPKAL--LALPFKGVRRLPPGELL 220
GlxB cd01907
Glutamine amidotransferases class-II (Gn-AT)_GlxB-type. GlxB is a glutamine ...
 211-445 3.06e-15

Glutamine amidotransferases class-II (Gn-AT)_GlxB-type. GlxB is a glutamine amidotransferase-like protein of unknown function found in bacteria and archaea. GlxB has a structural fold similar to that of other class II glutamine amidotransferases including glucosamine-fructose 6-phosphate synthase (GLMS or GFAT), glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase), asparagine synthetase B (AsnB), beta lactam synthetase (beta-LS) and glutamate synthase (GltS). The GlxB fold is also somewhat similar to the Ntn (N-terminal nucleophile) hydrolase fold of the proteasomal alpha and beta subunits.


Pssm-ID: 238888 [Multi-domain]  Cd Length: 249  Bit Score: 77.31  E-value: 3.06e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770  211 EADGGDLGFY------IVSLSTTTIVYKGMFLAYQVGAYYkDLadERFQSAVALVHQRFSTNTFPSWKLAHPYRM----V 280
Cdd:cd01907    31 PGDGAGFALYgdpdafVYSSGKDMEVFKGVGYPEDIARRY-DL--EEYKGYHWIAHTRQPTNSAVWWYGAHPFSIgdiaV 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770  281 AHNGEINTLRGNVNWMaarqasvssplfgddisKLWPISYEGQSDTACFDNALEFLVRGGYSLSHAVMMLIPEAWAGNQL 360
Cdd:cd01907   108 VHNGEISNYGSNREYL-----------------ERFGYKFETETDTEVIAYYLDLLLRKGGLPLEYYKHIIRMPEEEREL 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770  361 MSPERkafYEYHAALMepwDGPAAVAFTDGRQIGATLDRNGLRPArYIVTSDDRVIMASE----AGVLPVAEDKIvkkWR 436
Cdd:cd01907   171 LLALR---LTYRLADL---DGPFTIIVGTPDGFIVIRDRIKLRPA-VVAETDDYVAIASEecaiREIPDRDNAKV---WE 240


                  ....*....
gi 503610770  437 LQPGKMLLI 445
Cdd:cd01907   241 PRPGEYVIW 249
TIM_phosphate_binding cd04722
TIM barrel proteins share a structurally conserved phosphate binding motif and in general ...
 1036-1160 1.10e-05

TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate comes either from the substrate, as in the case of inosine monophosphate dehydrogenase (IMPDH), or from ribulose-5-phosphate 3-epimerase (RPE) or from cofactors, like FMN.


Pssm-ID: 240073 [Multi-domain]  Cd Length: 200  Bit Score: 47.97  E-value: 1.10e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503610770 1036 PHHDIYSIEDLAQLIYDLKNVNPEADVSVKLVseVGVGTVAAGVAKARADHITIAGFDGGTGASPLTslkhagspweigl 1115
Cdd:cd04722    91 HGAVGYLAREDLELIRELREAVPDVKVVVKLS--PTGELAAAAAEEAGVDEVGLGNGGGGGGGRDAV------------- 155

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 503610770 1116 AETQQTLVLNGLRSRIALQVDGGLKTGRDVVIGALLGADEFGFAT 1160
Cdd:cd04722   156 PIADLLLILAKRGSKVPVIAGGGINDPEDAAEALALGADGVIVGS 200
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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