DUF86 domain-containing protein [Nitrosomonas sp. Is79A3]
List of domain hits
Name | Accession | Description | Interval | E-value | |||
YutE | COG2445 | Uncharacterized HEPN domain protein YutE, UPF0331/DUF86 family [General function prediction ... |
5-134 | 8.46e-38 | |||
Uncharacterized HEPN domain protein YutE, UPF0331/DUF86 family [General function prediction only]; : Pssm-ID: 441985 Cd Length: 132 Bit Score: 125.01 E-value: 8.46e-38
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Name | Accession | Description | Interval | E-value | |||
YutE | COG2445 | Uncharacterized HEPN domain protein YutE, UPF0331/DUF86 family [General function prediction ... |
5-134 | 8.46e-38 | |||
Uncharacterized HEPN domain protein YutE, UPF0331/DUF86 family [General function prediction only]; Pssm-ID: 441985 Cd Length: 132 Bit Score: 125.01 E-value: 8.46e-38
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HepT-like | pfam01934 | Ribonuclease HepT-like; This family includes the toxic component HepT of a type II ... |
13-132 | 3.64e-21 | |||
Ribonuclease HepT-like; This family includes the toxic component HepT of a type II toxin-antitoxin (TA) system, which has RNase activity. These proteins contain a HEPN (higher eukaryotes and prokaryotes nucleotide-binding) domain and are neutralized through tri-AMPylation by the cognate antitoxin MntA, containing a MNT (minimal nucleotidyltransferase) domain. HepT-MnA form an heterooctamer (at a 2:6 ratio), a rare organization for this kind of TA systems. HepT dimerizes and enables the formation of a deep cleft at the HEPN-domain interface, containing the RX4-6H motif (where X is any amino acid and the residue immediately after the conserved R is typically a polar amino acid) as the active site that functions as an RNA-cleaving RNase. This type II TA system regulates cell motility and confers plasmid stability. Due to the prevalence of these HEPN/MNT modules in bacteria and archaea, it has been suggested that these TA systems may also play a role in the environmental adaptation to extreme habitats. Pssm-ID: 460390 Cd Length: 120 Bit Score: 82.01 E-value: 3.64e-21
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Name | Accession | Description | Interval | E-value | |||
YutE | COG2445 | Uncharacterized HEPN domain protein YutE, UPF0331/DUF86 family [General function prediction ... |
5-134 | 8.46e-38 | |||
Uncharacterized HEPN domain protein YutE, UPF0331/DUF86 family [General function prediction only]; Pssm-ID: 441985 Cd Length: 132 Bit Score: 125.01 E-value: 8.46e-38
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HepT-like | pfam01934 | Ribonuclease HepT-like; This family includes the toxic component HepT of a type II ... |
13-132 | 3.64e-21 | |||
Ribonuclease HepT-like; This family includes the toxic component HepT of a type II toxin-antitoxin (TA) system, which has RNase activity. These proteins contain a HEPN (higher eukaryotes and prokaryotes nucleotide-binding) domain and are neutralized through tri-AMPylation by the cognate antitoxin MntA, containing a MNT (minimal nucleotidyltransferase) domain. HepT-MnA form an heterooctamer (at a 2:6 ratio), a rare organization for this kind of TA systems. HepT dimerizes and enables the formation of a deep cleft at the HEPN-domain interface, containing the RX4-6H motif (where X is any amino acid and the residue immediately after the conserved R is typically a polar amino acid) as the active site that functions as an RNA-cleaving RNase. This type II TA system regulates cell motility and confers plasmid stability. Due to the prevalence of these HEPN/MNT modules in bacteria and archaea, it has been suggested that these TA systems may also play a role in the environmental adaptation to extreme habitats. Pssm-ID: 460390 Cd Length: 120 Bit Score: 82.01 E-value: 3.64e-21
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HEPN | COG2361 | HEPN domain protein, predicted toxin of MNT-HEPN system [Defense mechanisms]; |
93-122 | 1.07e-04 | |||
HEPN domain protein, predicted toxin of MNT-HEPN system [Defense mechanisms]; Pssm-ID: 441928 Cd Length: 115 Bit Score: 39.09 E-value: 1.07e-04
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Blast search parameters | ||||
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