|
Name |
Accession |
Description |
Interval |
E-value |
| phoR_proteo |
TIGR02966 |
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory ... |
94-425 |
2.97e-170 |
|
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory histidine kinase PhoR associated with the phosphate ABC transporter in most Proteobacteria. Related proteins from Gram-positive organisms are not included in this model. The phoR gene usually is adjacent to the response regulator phoB gene (TIGR02154). [Signal transduction, Two-component systems]
Pssm-ID: 274368 [Multi-domain] Cd Length: 333 Bit Score: 480.55 E-value: 2.97e-170
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 94 LSLALERMRSVTSAMPDGIVILDETDRIEWCNPVAEQHLGINLSLDTGQQITYLVRQIPFVEYLAARKYSNPLILNQTRQ 173
Cdd:TIGR02966 1 LSALLSRFRAAAQALPDAVVVLDEEGQIEWCNPAAERLLGLRWPDDLGQRITNLIRHPEFVEYLAAGRFSEPLELPSPIN 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 174 QGIIVSLQLVPYGYNQKLLISRDITRFEKIETMRRDFIANVSHELRTPLTVISGFLETLSADENVNSGFNKRALVLMSEQ 253
Cdd:TIGR02966 81 SERVLEIRIAPYGEEQKLLVARDVTRLRRLEQMRRDFVANVSHELRTPLTVLRGYLETLADGPDEDPEEWNRALEIMLEQ 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 254 TTRMQRLIEDLLILSRLENEQSIVNEKAVEVTSLLRGILQDAESLSAGR-HQIKLNIASQDQLLGSEEELRSAFGNLISN 332
Cdd:TIGR02966 161 SQRMQSLVEDLLTLSRLESAASPLEDEPVDMPALLDHLRDEAEALSQGKnHQITFEIDGGVDVLGDEDELRSAFSNLVSN 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 333 AIRYTPDSGEININWEKRDGQGLFFVQDSGIGIEPEHIPRLTERFYRVDSSRSRETGGTGLGLAIVKHVLSRHQARMEIT 412
Cdd:TIGR02966 241 AIKYTPEGGTITVRWRRDGGGAEFSVTDTGIGIAPEHLPRLTERFYRVDKSRSRDTGGTGLGLAIVKHVLSRHHARLEIE 320
|
330
....*....|...
gi 503732216 413 SQVGKGSRFTIWF 425
Cdd:TIGR02966 321 SELGKGSTFSFIF 333
|
|
| phoR |
PRK11006 |
phosphate regulon sensor histidine kinase PhoR; |
20-435 |
4.63e-131 |
|
phosphate regulon sensor histidine kinase PhoR;
Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 384.36 E-value: 4.63e-131
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 20 VLWMIFGAVKALLFFGVVMLWIafHHIRYLAALERWLRLsDHSpASIPAGSGAWDDVFAHLARYVRQHSQSQELLSLALE 99
Cdd:PRK11006 23 ILGAFFGYLPWFLLASVTGLLI--WHFWNLLRLSWWLWV-DRS-MTPPPGRGSWEPLFYGLYQMQLRNRKRRRELGNLIK 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 100 RMRSVTSAMPDGIVILDETDRIEWCNPVAEQHLGINLSLDTGQQITYLVRQIPFVEYLAARKYSNPL--ILNQTRqqgiI 177
Cdd:PRK11006 99 RFRSGAESLPDAVVLTTEEGNIFWCNGLAQQLLGFRWPEDNGQNILNLLRYPEFTQYLKTRDFSRPLtlVLNNGR----H 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 178 VSLQLVPYGYNQKLLISRDITRFEKIETMRRDFIANVSHELRTPLTVISGFLEtLSADENVNSGFNKRALVLMSEQTTRM 257
Cdd:PRK11006 175 LEIRVMPYTEGQLLMVARDVTQMHQLEGARRNFFANVSHELRTPLTVLQGYLE-MMQDQPLEGALREKALHTMREQTQRM 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 258 QRLIEDLLILSRLENEQSIVNEKAVEVTSLLRGILQDAESLSAGRHQIKLNIASQDQLLGSEEELRSAFGNLISNAIRYT 337
Cdd:PRK11006 254 EGLVKQLLTLSKIEAAPTIDLNEKVDVPMMLRVLEREAQTLSQGKHTITFEVDNSLKVFGNEDQLRSAISNLVYNAVNHT 333
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 338 PDSGEININWEKRDGQGLFFVQDSGIGIEPEHIPRLTERFYRVDSSRSRETGGTGLGLAIVKHVLSRHQARMEITSQVGK 417
Cdd:PRK11006 334 PEGTHITVRWQRVPQGAEFSVEDNGPGIAPEHIPRLTERFYRVDKARSRQTGGSGLGLAIVKHALSHHDSRLEIESEVGK 413
|
410
....*....|....*...
gi 503732216 418 GSRFTIWFPaKRLIPENK 435
Cdd:PRK11006 414 GTRFSFVLP-ERLIAKNS 430
|
|
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
76-429 |
1.33e-96 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 295.31 E-value: 1.33e-96
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 76 VFAHLARYVRQHSQSQELLSLALERMRSVTSAMPDGIVILDETDRIEWCNPVAEQHLGINLSLDTGQQITYLVRQIPFVE 155
Cdd:COG5002 34 LLLLLLLLLLLLLLLLLLLALLLLLLLLLLLLLALLLLLLLLLLLLALALLLLALLLLLLLLLLLLALLILLLLLALLIL 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 156 YLAARKYSNPLILNQTRQQGIIVSLQLVPYGYNQKLLISRDITRFEKIETMRRDFIANVSHELRTPLTVISGFLETLSAD 235
Cdd:COG5002 114 LAALLLLLSELLLLLLLLGRLSLRLSALLLGLLLLAAVERDITELERLEQMRREFVANVSHELRTPLTSIRGYLELLLDG 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 236 ENVNSGFNKRALVLMSEQTTRMQRLIEDLLILSRLENEQSIVNEKAVEVTSLLRGILQDAESLSAGR-HQIKLNIASQD- 313
Cdd:COG5002 194 AADDPEERREYLEIILEEAERLSRLVNDLLDLSRLESGELKLEKEPVDLAELLEEVVEELRPLAEEKgIELELDLPEDPl 273
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 314 QLLGSEEELRSAFGNLISNAIRYTPDSGEININWEKRDGQGLFFVQDSGIGIEPEHIPRLTERFYRVDSSRSRETGGTGL 393
Cdd:COG5002 274 LVLGDPDRLEQVLTNLLDNAIKYTPEGGTITVSLREEDDQVRISVRDTGIGIPEEDLPRIFERFYRVDKSRSRETGGTGL 353
|
330 340 350
....*....|....*....|....*....|....*.
gi 503732216 394 GLAIVKHVLSRHQARMEITSQVGKGSRFTIWFPAKR 429
Cdd:COG5002 354 GLAIVKHIVEAHGGRIWVESEPGKGTTFTITLPLAR 389
|
|
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
193-427 |
6.48e-69 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 218.62 E-value: 6.48e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 193 ISRDITRFEKIETMRRDFIANVSHELRTPLTVISGFLETLSADENVNSGFNKRALVLMSEQTTRMQRLIEDLLILSRLEN 272
Cdd:COG2205 2 LEEALEELEELERLKSEFLANVSHELRTPLTSILGAAELLLDEEDLSPEERRELLEIIRESAERLLRLIEDLLDLSRLES 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 273 EQSIVNEKAVEVTSLLRGILQDAESLSAGR-HQIKLNIASQD-QLLGSEEELRSAFGNLISNAIRYTPDSGEININWEKR 350
Cdd:COG2205 82 GKLSLELEPVDLAELLEEAVEELRPLAEEKgIRLELDLPPELpLVYADPELLEQVLANLLDNAIKYSPPGGTITISARRE 161
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 503732216 351 DGQGLFFVQDSGIGIEPEHIPRLTERFYRVDSSRSreTGGTGLGLAIVKHVLSRHQARMEITSQVGKGSRFTIWFPA 427
Cdd:COG2205 162 GDGVRISVSDNGPGIPEEELERIFERFYRGDNSRG--EGGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTLPL 236
|
|
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
191-427 |
2.70e-66 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 214.77 E-value: 2.70e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 191 LLISRDITRFEKIETMRRDFIANVSHELRTPLTVISGFLETLSADENVNSgfnKRALVLMSEQTTRMQRLIEDLLILSRL 270
Cdd:COG0642 94 LLLLALLLLLEEANEAKSRFLANVSHELRTPLTAIRGYLELLLEELDEEQ---REYLETILRSADRLLRLINDLLDLSRL 170
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 271 ENEQSIVNEKAVEVTSLLRGILQDAESLsAGRHQIKLNIASQDQL---LGSEEELRSAFGNLISNAIRYTPDSGEININW 347
Cdd:COG0642 171 EAGKLELEPEPVDLAELLEEVVELFRPL-AEEKGIELELDLPDDLptvRGDPDRLRQVLLNLLSNAIKYTPEGGTVTVSV 249
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 348 EKRDGQGLFFVQDSGIGIEPEHIPRLTERFYRVDSsrSRETGGTGLGLAIVKHVLSRHQARMEITSQVGKGSRFTIWFPA 427
Cdd:COG0642 250 RREGDRVRISVEDTGPGIPPEDLERIFEPFFRTDP--SRRGGGTGLGLAIVKRIVELHGGTIEVESEPGKGTTFTVTLPL 327
|
|
| HK_WalK |
NF033092 |
cell wall metabolism sensor histidine kinase WalK; This model describes WalK as found in ... |
99-426 |
3.56e-57 |
|
cell wall metabolism sensor histidine kinase WalK; This model describes WalK as found in Staphylococcus aureus (sp|Q2G2U4.1|WALK_STAA8). A shorter version, as found in Streptococcus pneumoniae, called WalK(Spn) or VicK, is not included. WalK is part of a two-component system and works with partner protein WalR.
Pssm-ID: 467964 [Multi-domain] Cd Length: 594 Bit Score: 198.05 E-value: 3.56e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 99 ERMRSVTSAMPDGIVILDETDRIEWCNPVAEQHLGINLSLDTGQQITYLVR---QIPFVEYLAAR--------KYSNPLI 167
Cdd:NF033092 258 RKLDSVLSHMTDGVIATDRRGRVILINDPALEMLNVSRETVLGQSILDVLGleeEYTLRDLLEEQdsllldfsTEEEPLI 337
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 168 LNQT-----RQQ----GIIVSLQlvpygynqkllisrDITRFEKIETMRRDFIANVSHELRTPLTVISGFLETLS----A 234
Cdd:NF033092 338 LRANfsviqRESgfinGLIAVLH--------------DVTEQEKIEQERREFVANVSHELRTPLTTMRSYLEALAdgawK 403
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 235 DENVNSGFNKralVLMSEqTTRMQRLIEDLLILSRLENEQSIVNEKAVEVTSLLRGILQDAESLSAGRH-QIKLNIASQD 313
Cdd:NF033092 404 DPELAPRFLG---VTQNE-TERMIRLVNDLLQLSRMDSKDYKLNKEWVNFNEFFNYIIDRFEMILKNKNiTFKREFPKRD 479
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 314 -----------QLLgseeelrsafGNLISNAIRYTPDSGEININWEKRDGQGLFFVQDSGIGIEPEHIPRLTERFYRVDS 382
Cdd:NF033092 480 lwveidtdkitQVL----------DNIISNAIKYSPEGGTITFRLLETHNRIIISISDQGLGIPKKDLDKIFDRFYRVDK 549
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 503732216 383 SRSRETGGTGLGLAIVKHVLSRHQARMEITSQVGKGSRFTIWFP 426
Cdd:NF033092 550 ARSRKMGGTGLGLAIAKEVVEAHGGRIWAESEEGKGTTIYFTLP 593
|
|
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
30-429 |
5.71e-56 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 190.56 E-value: 5.71e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 30 ALLFFGVVMLWIAFHHIRYLA--------ALERwLRLSDHSPaSIPAGSgawDDVFAHLAR----YVRQHSQSQELLSLA 97
Cdd:COG5000 14 IALLLLLLALWLALLLARRLTrplrrlaeATRA-VAAGDLSV-RLPVTG---DDEIGELARafnrMTDQLKEQREELEER 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 98 LERMRSVTSAMPDGIVILDETDRIEWCNPVAEQHLGINLSLDTGQQITYLVRQIPFVEYLA-ARKYSNPLILNQTRQQGI 176
Cdd:COG5000 89 RRYLETILENLPAGVIVLDADGRITLANPAAERLLGIPLEELIGKPLEELLPELDLAELLReALERGWQEEIELTRDGRR 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 177 IVSLQLVPYGYNQKLLISRDITRFEKIETMR--RDFIANVSHELRTPLTVISGFLETL-----SADENVNSGFnKRALVL 249
Cdd:COG5000 169 TLLVRASPLRDDGYVIVFDDITELLRAERLAawGELARRIAHEIKNPLTPIQLSAERLrrklaDKLEEDREDL-ERALDT 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 250 MSEQTTRMQRLIEDLLILSRLENEQSivneKAVEVTSLLRGILQDAESlSAGRHQIKLNIASQDQLL---GSEEELRSAF 326
Cdd:COG5000 248 IIRQVDRLKRIVDEFLDFARLPEPQL----EPVDLNELLREVLALYEP-ALKEKDIRLELDLDPDLPevlADRDQLEQVL 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 327 GNLISNAIRYTPDSGEININWEKRDGQGLFFVQDSGIGIEPEHIPRLTERFYrvdSSRSRetgGTGLGLAIVKHVLSRHQ 406
Cdd:COG5000 323 INLLKNAIEAIEEGGEIEVSTRREDGRVRIEVSDNGPGIPEEVLERIFEPFF---TTKPK---GTGLGLAIVKKIVEEHG 396
|
410 420
....*....|....*....|...
gi 503732216 407 ARMEITSQVGKGSRFTIWFPAKR 429
Cdd:COG5000 397 GTIELESRPGGGTTFTIRLPLAE 419
|
|
| HATPase_EcPhoR-like |
cd16952 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
322-429 |
3.14e-52 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.
Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 170.85 E-value: 3.14e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 322 LRSAFGNLISNAIRYTPDSGEININWEKRDGQGLFFVQDSGIGIEPEHIPRLTERFYRVDSSRSRETGGTGLGLAIVKHV 401
Cdd:cd16952 1 LRSAFSNLVSNAVKYTPPSDTITVRWSQEESGARLSVEDTGPGIPPEHIPRLTERFYRVDIERCRNTGGTGLGLAIVKHV 80
|
90 100
....*....|....*....|....*...
gi 503732216 402 LSRHQARMEITSQVGKGSRFTIWFPAKR 429
Cdd:cd16952 81 MSRHDARLLIASELGKGSRFTCLFPSSR 108
|
|
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
94-429 |
3.74e-50 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 173.49 E-value: 3.74e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 94 LSLALERMRSVTSAMPDGIVILDETDRIEWCNPVAEQHLGINLSLDTGQQITYLVRQ-IPFVEYLA-ARKYSNPLILNQT 171
Cdd:COG3852 2 LRESEELLRAILDSLPDAVIVLDADGRITYVNPAAERLLGLSAEELLGRPLAELFPEdSPLRELLErALAEGQPVTEREV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 172 RQQG-----IIVSLQLVPYGYNQK----LLISRDITRFEKIE-TMRR--------DFIANVSHELRTPLTVISGFLETLS 233
Cdd:COG3852 82 TLRRkdgeeRPVDVSVSPLRDAEGeggvLLVLRDITERKRLErELRRaeklaavgELAAGLAHEIRNPLTGIRGAAQLLE 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 234 adENVNSGFNKRALVLMSEQTTRMQRLIEDLLILSRleneQSIVNEKAVEVTSLLRGILQDAESLSAGRHQIKLNIA-SQ 312
Cdd:COG3852 162 --RELPDDELREYTQLIIEEADRLNNLVDRLLSFSR----PRPPEREPVNLHEVLERVLELLRAEAPKNIRIVRDYDpSL 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 313 DQLLGSEEELRSAFGNLISNAIRYTPDSGEINI---------NWEKRDGQGLFF-VQDSGIGIEPEHIPRLTERFYrvdS 382
Cdd:COG3852 236 PEVLGDPDQLIQVLLNLVRNAAEAMPEGGTITIrtrverqvtLGGLRPRLYVRIeVIDNGPGIPEEILDRIFEPFF---T 312
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 503732216 383 SRsreTGGTGLGLAIVKHVLSRHQARMEITSQVGKGSRFTIWFPAKR 429
Cdd:COG3852 313 TK---EKGTGLGLAIVQKIVEQHGGTIEVESEPGKGTTFRIYLPLEQ 356
|
|
| KinE |
COG5809 |
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ... |
82-428 |
2.44e-44 |
|
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 161.30 E-value: 2.44e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 82 RYVRQHSQSQELLslalermRSVTSAMPDGIVILDETDRIEWCNPVAEQHLGINLSLDTGQQITYLVR---QIPFVEYLA 158
Cdd:COG5809 131 RMEEALRESEEKF-------RLIFNHSPDGIIVTDLDGRIIYANPAACKLLGISIEELIGKSILELIHsddQENVAAFIS 203
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 159 ARKYSNPLILNQTR-----QQGIIVSLQLVPYGYNQK----LLISRDIT-RFEKIETMRR--------DFIANVSHELRT 220
Cdd:COG5809 204 QLLKDGGIAQGEVRfwtkdGRWRLLEASGAPIKKNGEvdgiVIIFRDITeRKKLEELLRKseklsvvgELAAGIAHEIRN 283
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 221 PLTVISGFLETLSADENVNsgfNKRALVLMSEQTTRMQRLIEDLLILSRLEN---EQSIVNEKAVEVTSLLrgilqDAES 297
Cdd:COG5809 284 PLTSLKGFIQLLKDTIDEE---QKTYLDIMLSELDRIESIISEFLVLAKPQAikyEPKDLNTLIEEVIPLL-----QPQA 355
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 298 LsagRHQIKLNIASQDQ---LLGSEEELRSAFGNLISNAIRYTPDSGEININWEKRDGQGLFF-VQDSGIGIEPEHIPRL 373
Cdd:COG5809 356 L---LKNVQIELELEDDipdILGDENQLKQVFINLLKNAIEAMPEGGNITIETKAEDDDKVVIsVTDEGCGIPEERLKKL 432
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 503732216 374 TERFYrvdssrSRETGGTGLGLAIVKHVLSRHQARMEITSQVGKGSRFTIWFPAK 428
Cdd:COG5809 433 GEPFY------TTKEKGTGLGLMVSYKIIEEHGGKITVESEVGKGTTFSITLPIK 481
|
|
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
208-428 |
7.13e-43 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 157.64 E-value: 7.13e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 208 RDFIANVSHELRTPLTVISGFLETLSAD-ENVNSGFNKRALVLMSEQTTRMQRLIEDLLILSRLENEQsiVNEKAVEVTS 286
Cdd:COG4251 283 EQFAYVASHDLREPLRKISGFSQLLEEDyGDKLDEEGREYLERIRDAAERMQALIDDLLAYSRVGRQE--LEFEPVDLNE 360
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 287 LLRGILQDAESLSAGRHqIKLNIASQDQLLGSEEELRSAFGNLISNAIRYTPD--SGEININWEKRDGQGLFFVQDSGIG 364
Cdd:COG4251 361 LLEEVLEDLEPRIEERG-AEIEVGPLPTVRGDPTLLRQVFQNLISNAIKYSRPgePPRIEIGAEREGGEWVFSVRDNGIG 439
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 503732216 365 IEPEHIPRLTERFYRVDSSRSREtgGTGLGLAIVKHVLSRHQARMEITSQVGKGSRFTIWFPAK 428
Cdd:COG4251 440 IDPEYAEKIFEIFQRLHSRDEYE--GTGIGLAIVKKIVERHGGRIWVESEPGEGATFYFTLPKA 501
|
|
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
203-429 |
3.42e-40 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 149.61 E-value: 3.42e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 203 IETMRR---------DFIANVSHELRTPLTVISGFLETLsaDENVNSGFNKRALVLMSEQTTRMQRLIEDLLILSRLENE 273
Cdd:PRK11100 243 LESMRVklegkayveQYVQTLTHELKSPLAAIRGAAELL--QEDPPPEDRARFTGNILTQSARLQQLIDRLLELARLEQR 320
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 274 QSIVNEKAVEVTSLLRGILQDAESLSAGRHqIKLNIASQD-QLLGSEEELRSAFGNLISNAIRYTPDSGEININWEKRDG 352
Cdd:PRK11100 321 QELEVLEPVALAALLEELVEAREAQAAAKG-ITLRLRPDDaRVLGDPFLLRQALGNLLDNAIDFSPEGGTITLSAEVDGE 399
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 353 QGLFFVQDSGIGIePEH-IPRLTERFY---RVDSSRSretgGTGLGLAIVKHVLSRHQARMEITSQVGKGSRFTIWFPAK 428
Cdd:PRK11100 400 QVALSVEDQGPGI-PDYaLPRIFERFYslpRPANGRK----STGLGLAFVREVARLHGGEVTLRNRPEGGVLATLTLPRH 474
|
.
gi 503732216 429 R 429
Cdd:PRK11100 475 F 475
|
|
| cztS_silS_copS |
TIGR01386 |
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ... |
209-426 |
1.99e-37 |
|
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.
Pssm-ID: 273593 [Multi-domain] Cd Length: 457 Bit Score: 141.76 E-value: 1.99e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 209 DFIANVSHELRTPLTVISGFLETLSADENVNSGFnkRALVLMS-EQTTRMQRLIEDLLILSRLENEQSIVNEKAVEVTSL 287
Cdd:TIGR01386 243 QFSADLAHELRTPLTNLLGQTQVALSQPRTGEEY--REVLESNlEELERLSRMVSDMLFLARADNGQLALERVRLDLAAE 320
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 288 LRGILQDAESLSAGRhQIKLNIASQDQLLGSEEELRSAFGNLISNAIRYTPDSGEININWEKRDGQGLFFVQDSGIGIEP 367
Cdd:TIGR01386 321 LAKVAEYFEPLAEER-GVRIRVEGEGLVRGDPQMFRRAISNLLSNALRHTPDGGTITVRIERRSDEVRVSVSNPGPGIPP 399
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 503732216 368 EHIPRLTERFYRVDSSRSRETGGTGLGLAIVKHVLSRHQARMEITSQVGKgSRFTIWFP 426
Cdd:TIGR01386 400 EHLSRLFDRFYRVDPARSNSGEGTGLGLAIVRSIMEAHGGRASAESPDGK-TRFILRFP 457
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
86-428 |
3.83e-36 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 138.71 E-value: 3.83e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 86 QHSQSQELLSLALERMRSVTSAMPDGIVILDETDRIEWCNPVAEQHLGINLSLDTGQQItYLVRQIPFVEYLAARkysnp 165
Cdd:COG5805 144 KKKKIEEILQEQEERLQTLIENSPDLICVIDTDGRILFINESIERLFGAPREELIGKNL-LELLHPCDKEEFKER----- 217
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 166 liLNQTRQQGIIVSLQLVPYGYNQKLL---------------------ISRDITRFEKIE-TMRR--------DFIANVS 215
Cdd:COG5805 218 --IESITEVWQEFIIEREIITKDGRIRyfeavivplidtdgsvkgilvILRDITEKKEAEeLMARseklsiagQLAAGIA 295
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 216 HELRTPLTVISGFLETLSADENVNSGFNKralvLMSEQTTRMQRLIEDLLILSR-------LENEQSIVNEkaveVTSLL 288
Cdd:COG5805 296 HEIRNPLTSIKGFLQLLQPGIEDKEEYFD----IMLSELDRIESIISEFLALAKpqavnkeKENINELIQD----VVTLL 367
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 289 --RGILQDAeslsagrhQIKLNIASQDQ-LLGSEEELRSAFGNLISNAIRYTPDSGEININWEKRDGQGLFFVQDSGIGI 365
Cdd:COG5805 368 etEAILHNI--------QIRLELLDEDPfIYCDENQIKQVFINLIKNAIEAMPNGGTITIHTEEEDNSVIIRVIDEGIGI 439
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 503732216 366 EPEHIPRLTERFYrvdssrSRETGGTGLGLAIVKHVLSRHQARMEITSQVGKGSRFTIWFPAK 428
Cdd:COG5805 440 PEERLKKLGEPFF------TTKEKGTGLGLMVSYKIIENHNGTIDIDSKVGKGTTFTITLPLS 496
|
|
| HATPase |
cd00075 |
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ... |
322-425 |
1.74e-35 |
|
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.
Pssm-ID: 340391 [Multi-domain] Cd Length: 102 Bit Score: 126.56 E-value: 1.74e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 322 LRSAFGNLISNAIRYTPDSGEININWEKRDGQGLFFVQDSGIGIEPEHIPRLTERFYRVDSsrSRETGGTGLGLAIVKHV 401
Cdd:cd00075 1 LEQVLSNLLDNALKYSPPGGTIEISLRQEGDGVVLEVEDNGPGIPEEDLERIFERFYRGDK--SREGGGTGLGLAIVRRI 78
|
90 100
....*....|....*....|....
gi 503732216 402 LSRHQARMEITSQVGKGSRFTIWF 425
Cdd:cd00075 79 VEAHGGRITVESEPGGGTTFTVTL 102
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
201-428 |
1.85e-35 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 134.54 E-value: 1.85e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 201 EKIETMRRdFIANVSHELRTPLTVISGFLETLS--ADENVNSGFNKRALVLMSEQTTRMQRLIEDLLILSRLENEQSivn 278
Cdd:COG4191 137 EKLAALGE-LAAGIAHEINNPLAAILGNAELLRrrLEDEPDPEELREALERILEGAERAAEIVRSLRAFSRRDEEER--- 212
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 279 eKAVEVTSLLRGILQDAES-LSAGRHQIKLNIASQD-QLLGSEEELRSAFGNLISNAIRYTPDS--GEININWEKRDGQG 354
Cdd:COG4191 213 -EPVDLNELIDEALELLRPrLKARGIEVELDLPPDLpPVLGDPGQLEQVLLNLLINAIDAMEEGegGRITISTRREGDYV 291
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 503732216 355 LFFVQDSGIGIEPEHIPRLTERFYrvdSSRsRETGGTGLGLAIVKHVLSRHQARMEITSQVGKGSRFTIWFPAK 428
Cdd:COG4191 292 VISVRDNGPGIPPEVLERIFEPFF---TTK-PVGKGTGLGLSISYGIVEKHGGRIEVESEPGGGTTFTITLPLA 361
|
|
| BaeS_SmeS |
NF012163 |
sensor histidine kinase efflux regulator BaeS; |
201-426 |
6.27e-35 |
|
sensor histidine kinase efflux regulator BaeS;
Pssm-ID: 411086 [Multi-domain] Cd Length: 457 Bit Score: 134.95 E-value: 6.27e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 201 EKIETMRRDFIANVSHELRTPLTVISGFLEtlsADENVNSGFNKRALVLMSEQTTRMQRLIEDLLILSrLENEQSIVNEK 280
Cdd:NF012163 234 EKNEQMRRDFMADISHELRTPLAVLRAELE---AIQDGIRKFTPESLDSLQAEVGTLTKLVDDLHDLS-MSDEGALAYQK 309
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 281 A-VEVTSLLRGILQD-AESLSAGRHQIKLNIASQDQLLGSEEELRSAFGNLISNAIRYTPDSGEININWEKRDGQGLFFV 358
Cdd:NF012163 310 AsVDLVPLLEVEGGAfRERFASAGLELEVSLPDSSLVFGDRDRLMQLFNNLLENSLRYTDSGGSLHISASQRPKEVTLTV 389
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 503732216 359 QDSGIGIEPEHIPRLTERFYRVDSSRSRETGGTGLGLAIVKHVLSRHQARMEITSQVGKGSRFTIWFP 426
Cdd:NF012163 390 ADSAPGVSDEQLARLFERFYRVEVSRNRASGGSGLGLAISLNIVQAHGGTLHAAHSPLGGLRIVVTLP 457
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
317-426 |
1.01e-34 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 124.68 E-value: 1.01e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 317 GSEEELRSAFGNLISNAIRYTPDSGEININWEKRDGQGLFFVQDSGIGIEPEHIPRLTERFYRVDsSRSRETGGTGLGLA 396
Cdd:smart00387 1 GDPDRLRQVLSNLLDNAIKYTPEGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTD-KRSRKIGGTGLGLS 79
|
90 100 110
....*....|....*....|....*....|
gi 503732216 397 IVKHVLSRHQARMEITSQVGKGSRFTIWFP 426
Cdd:smart00387 80 IVKKLVELHGGEISVESEPGGGTTFTITLP 109
|
|
| PRK10549 |
PRK10549 |
two-component system sensor histidine kinase BaeS; |
201-432 |
1.25e-34 |
|
two-component system sensor histidine kinase BaeS;
Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 133.99 E-value: 1.25e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 201 EKIETMRRDFIANVSHELRTPLTVISGFLETL------SADENVNSgfnkralvLMSEQTTrMQRLIEDLLILSrLENEQ 274
Cdd:PRK10549 234 EKNEQMRRDFMADISHELRTPLAVLRGELEAIqdgvrkFTPESVAS--------LQAEVGT-LTKLVDDLHQLS-LSDEG 303
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 275 SIVNEKA-VEVTSLL-------RGILQDaeslsagrHQIKLNIASQDQ--LLGSEEELRSAFGNLISNAIRYTPDSGEIN 344
Cdd:PRK10549 304 ALAYRKTpVDLVPLLevaggafRERFAS--------RGLTLQLSLPDSatVFGDPDRLMQLFNNLLENSLRYTDSGGSLH 375
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 345 INWEKRDGQGLFFVQDSGIGIEPEHIPRLTERFYRVDSSRSRETGGTGLGLAIVKHVLSRHQARMEITSQVGKGSRFTIW 424
Cdd:PRK10549 376 ISAEQRDKTLRLTFADSAPGVSDEQLQKLFERFYRTEGSRNRASGGSGLGLAICLNIVEAHNGRIIAAHSPFGGVSITVE 455
|
....*...
gi 503732216 425 FPAKRLIP 432
Cdd:PRK10549 456 LPLERDLQ 463
|
|
| PRK09835 |
PRK09835 |
Cu(+)/Ag(+) sensor histidine kinase; |
189-426 |
4.48e-33 |
|
Cu(+)/Ag(+) sensor histidine kinase;
Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 129.89 E-value: 4.48e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 189 QKLLISRD--ITRFEKIETMRRDFIANVSHELRTPLTVISGFLE-TLSADENvnsgfnKRAL--VLMS--EQTTRMQRLI 261
Cdd:PRK09835 242 EQLVLSFNhmIERIEDVFTRQSNFSADIAHEIRTPITNLITQTEiALSQSRS------QKELedVLYSnlEELTRMAKMV 315
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 262 EDLLILSRLENEQSIVNEKAVEVTSLLRGILQDAESLSAGRH-QIKLNiASQDQLLGSEEELRSAFGNLISNAIRYTPDS 340
Cdd:PRK09835 316 SDMLFLAQADNNQLIPEKKMLDLADEVGKVFDFFEAWAEERGvELRFV-GDPCQVAGDPLMLRRAISNLLSNALRYTPAG 394
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 341 GEININWEKRDGQGLFFVQDSGIGIEPEHIPRLTERFYRVDSSRSRETGGTGLGLAIVKHVLSRHQARMEITSQVgKGSR 420
Cdd:PRK09835 395 EAITVRCQEVDHQVQLVVENPGTPIAPEHLPRLFDRFYRVDPSRQRKGEGSGIGLAIVKSIVVAHKGTVAVTSDA-RGTR 473
|
....*.
gi 503732216 421 FTIWFP 426
Cdd:PRK09835 474 FVISLP 479
|
|
| KinB |
COG5806 |
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome ... |
189-428 |
1.61e-31 |
|
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444508 [Multi-domain] Cd Length: 412 Bit Score: 124.59 E-value: 1.61e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 189 QKLLISRDITRFEKIETMRrDFIANVSHELRTPLTVISGFLETLSADEnVNSGFNKRALVLMSEQTTRMQRLIEDLLILS 268
Cdd:COG5806 184 ENILLRKELQRAEKLEVVS-ELAASIAHEVRNPLTVVRGFIQLLQEPE-LSDEKRKQYIRIALEELDRAEAIITDYLTFA 261
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 269 RLENEQSivnEKaVEVTSLLRGILQDAESLSAGRH-QIKLNIASQDQLLGSEEELRSAFGNLISNAIRYTPDSGEININW 347
Cdd:COG5806 262 KPQPEKL---EK-IDVSEELEHVIDVLSPYANMNNvEIQTELEPGLYIEGDRQKLQQCLINIIKNGIEAMPNGGTLTIDV 337
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 348 EKRDGQGLFFVQDSGIGIEPEHIPRLTERFYrvdssrSRETGGTGLGLAIVKHVLSRHQARMEITSQVGKGSRFTIWFPA 427
Cdd:COG5806 338 SIDKNKVIISIKDTGVGMTKEQLERLGEPYF------STKEKGTGLGTMVSYRIIEAMNGTIRVESEVGKGTTFTITLPL 411
|
.
gi 503732216 428 K 428
Cdd:COG5806 412 A 412
|
|
| PRK11360 |
PRK11360 |
two-component system sensor histidine kinase AtoS; |
108-426 |
2.72e-30 |
|
two-component system sensor histidine kinase AtoS;
Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 123.15 E-value: 2.72e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 108 MPDGIVILDETDRIEWCNPVAEQHLGINLSLDTGQQITYLV-RQIPFVEYLAA-----RKYSNPLILNQTRQQGIIVSLQ 181
Cdd:PRK11360 271 IADGVIAIDRQGKITTMNPAAEVITGLQRHELVGKPYSELFpPNTPFASPLLDtlehgTEHVDLEISFPGRDRTIELSVS 350
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 182 LVPYGYNQK-----LLISRDIT-RFEKIETMRR--------DFIANVSHELRTPLTVISGFLETLSADENVNsgFNKRAL 247
Cdd:PRK11360 351 TSLLHNTHGemigaLVIFSDLTeRKRLQRRVARqerlaalgELVAGVAHEIRNPLTAIRGYVQIWRQQTSDP--PSQEYL 428
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 248 VLMSEQTTRMQRLIEDLLILSR---LENEQSIVNEKAVEVTSLLRGILQDAEslsagrhqIKLNIASQDQL---LGSEEE 321
Cdd:PRK11360 429 SVVLREVDRLNKVIDQLLEFSRpreSQWQPVSLNALVEEVLQLFQTAGVQAR--------VDFETELDNELppiWADPEL 500
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 322 LRSAFGNLISNAIRYTPDSGEININ-WEKRDGQGLFFVQDSGIGIEPEHIPRLTERFYrvdSSRSRetgGTGLGLAIVKH 400
Cdd:PRK11360 501 LKQVLLNILINAVQAISARGKIRIRtWQYSDGQVAVSIEDNGCGIDPELLKKIFDPFF---TTKAK---GTGLGLALSQR 574
|
330 340
....*....|....*....|....*.
gi 503732216 401 VLSRHQARMEITSQVGKGSRFTIWFP 426
Cdd:PRK11360 575 IINAHGGDIEVESEPGVGTTFTLYLP 600
|
|
| MtrAB_MtrB |
NF040691 |
MtrAB system histidine kinase MtrB; |
193-429 |
1.08e-29 |
|
MtrAB system histidine kinase MtrB;
Pssm-ID: 468655 [Multi-domain] Cd Length: 507 Bit Score: 120.90 E-value: 1.08e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 193 ISRDITRFEKIETMRRDFIANVSHELRTPLTVISGFLETLSADENVNSGFNKRALVLMSEQTTRMQRLIEDLLILSRLEN 272
Cdd:NF040691 257 LQRQIRQLEELSRLQQRFVSDVSHELRTPLTTIRMAADVIHDSRDDFDPATARSAELLHTELDRFESLLSDLLEISRFDA 336
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 273 EQSIVNEKAVEVTSLLRGILQDAESLSAGRH-QIKLNIASQDQLLGSEEE-----LRsafgNLISNAIRYTpDSGEININ 346
Cdd:NF040691 337 GAAELDVEPVDLRPLVRRVVDALRQLAERAGvELRVDAPGTPVVAEVDPRrvervLR----NLVVNAIEHG-EGKPVVVT 411
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 347 WEKRDGQGLFFVQDSGIGIEPEHIPRLTERFYRVDSSRSRETGGTGLGLAIVKHVLSRHQARMEITSQVGKGSRFTIWFP 426
Cdd:NF040691 412 VAQDDTAVAVTVRDHGVGLKPGEVALVFDRFWRADPARARTTGGTGLGLAIALEDARLHGGWLEAWGRPGQGSQFRLTLP 491
|
...
gi 503732216 427 AKR 429
Cdd:NF040691 492 RVA 494
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
317-429 |
2.33e-28 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 107.84 E-value: 2.33e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 317 GSEEELRSAFGNLISNAIRYTPDSGEININWEkRDGQGLFFVQDSGIGIEPEHIPRLTERFYRVDSsrsRETGGTGLGLA 396
Cdd:pfam02518 1 GDELRLRQVLSNLLDNALKHAAKAGEITVTLS-EGGELTLTVEDNGIGIPPEDLPRIFEPFSTADK---RGGGGTGLGLS 76
|
90 100 110
....*....|....*....|....*....|...
gi 503732216 397 IVKHVLSRHQARMEITSQVGKGSRFTIWFPAKR 429
Cdd:pfam02518 77 IVRKLVELLGGTITVESEPGGGTTVTLTLPLAQ 109
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
30-429 |
1.36e-27 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 113.02 E-value: 1.36e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 30 ALLFFGVVMLWIAFHHIRYLAALERWLRLSDHSPASIPAGSGAWDDVFAHLARYVRQHSQSQELLSLALERMRSVTSAMP 109
Cdd:COG3290 15 LILILILLLLLLIILLLILLLVLLLLLFLLFVIILLLLLLILLLILLLLLLLLLAALLLKLLEEIARLVEEREAVLESIR 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 110 DGIVILDETDRIEWCNPVAEQHLGINLsldTGQQITYLVRqipfvEYLAARKYSNPLILNqtrqqGIIVSLQLVPYGYNQ 189
Cdd:COG3290 95 EGVIAVDRDGRITLINDAARRLLGLDA---IGRPIDEVLA-----EVLETGERDEEILLN-----GRVLVVNRVPIRDDG 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 190 KLL----ISRDITRFEK-----------IETMRRdfianVSHELRTPLTVISGFLETLSADEnvnsgfnkrALVLMSEQT 254
Cdd:COG3290 162 RVVgavaTFRDRTELERleeelegvkelAEALRA-----QRHDFRNHLHTISGLLQLGEYDE---------ALEYIDEIS 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 255 TRMQRLIEDLLIlsRLENeqsivnekavevtSLLRGILQDAESLSAGRHqIKLNIASQDQLLG---SEEELRSAFGNLIS 331
Cdd:COG3290 228 EELQELIDSLLS--RIGN-------------PVLAALLLGKAARARERG-IDLTIDIDSDLPDlplSDTDLVTILGNLLD 291
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 332 NAIRYT----PDSGEININWEKRDGQGLFFVQDSGIGIEPEHIPRLTERFYRvdssrSRETGGTGLGLAIVKHVLSRHQA 407
Cdd:COG3290 292 NAIEAVeklpEEERRVELSIRDDGDELVIEVEDSGPGIPEELLEKIFERGFS-----TKLGEGRGLGLALVKQIVEKYGG 366
|
410 420
....*....|....*....|..
gi 503732216 408 RMEITSQVGKGSRFTIWFPAKR 429
Cdd:COG3290 367 TIEVESEEGEGTVFTVRLPKEG 388
|
|
| HATPase_EvgS-ArcB-TorS-like |
cd16922 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ... |
328-426 |
2.95e-27 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 104.88 E-value: 2.95e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 328 NLISNAIRYTPdSGEI--NINWEKRDGQG---LFFVQDSGIGIEPEHIPRLTERFYRVDSSRSRETGGTGLGLAIVKHVL 402
Cdd:cd16922 7 NLLGNAIKFTE-EGEVtlRVSLEEEEEDGvqlRFSVEDTGIGIPEEQQARLFEPFSQADSSTTRKYGGTGLGLAISKKLV 85
|
90 100
....*....|....*....|....
gi 503732216 403 SRHQARMEITSQVGKGSRFTIWFP 426
Cdd:cd16922 86 ELMGGDISVESEPGQGSTFTFTLP 109
|
|
| PRK10604 |
PRK10604 |
sensor protein RstB; Provisional |
201-433 |
4.41e-27 |
|
sensor protein RstB; Provisional
Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 112.39 E-value: 4.41e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 201 EKIETM---RRDFIANVSHELRTPLTVIS---GFLETLSADENVnsGFNKralvlmseQTTRMQRLIEDLLILSRLENEQ 274
Cdd:PRK10604 203 DNINALiasKKQLIDGIAHELRTPLVRLRyrlEMSDNLSAAESQ--ALNR--------DIGQLEALIEELLTYARLDRPQ 272
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 275 SIVNEKAVEVTSLLRGILQDAESLSAGRHqIKLNIASQDQLLGSEEELRS-AFGNLISNAIRYTPDSGEININWEkrDGQ 353
Cdd:PRK10604 273 NELHLSEPDLPAWLSTHLADIQAVTPEKT-VRLDTPHQGDYGALDMRLMErVLDNLLNNALRYAHSRVRVSLLLD--GNQ 349
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 354 GLFFVQDSGIGIEPEHIPRLTERFYRVDSSRSRETGGTGLGLAIVKHVLSRHQARMEITSQVGKGSRFTIWFPAKRLIPE 433
Cdd:PRK10604 350 ACLIVEDDGPGIPPEERERVFEPFVRLDPSRDRATGGCGLGLAIVHSIALAMGGSVNCDESELGGARFSFSWPVWHNLPQ 429
|
|
| HATPase_CpxA-like |
cd16949 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
322-427 |
1.20e-25 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.
Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 100.09 E-value: 1.20e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 322 LRSAFGNLISNAIRYTPdsGEININWEKRDGQGLFFVQDSGIGIEPEHIPRLTERFYRVDSSRSRETGGTGLGLAIVKHV 401
Cdd:cd16949 1 LARALENVLRNALRYSP--SKILLDISQDGDQWTITITDDGPGVPEDQLEQIFLPFYRVDSARDRESGGTGLGLAIAERA 78
|
90 100
....*....|....*....|....*.
gi 503732216 402 LSRHQARMEITSQVGKGSRFTIWFPA 427
Cdd:cd16949 79 IEQHGGKIKASNRKPGGLRVRIWLPA 104
|
|
| cpxA |
PRK09470 |
envelope stress sensor histidine kinase CpxA; |
211-426 |
2.31e-24 |
|
envelope stress sensor histidine kinase CpxA;
Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 104.63 E-value: 2.31e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 211 IANVSHELRTPLTVIsgfletlsadenvnsgfnKRALVLM------SEQTTRM----QRL---IEDLLILSRLENEQSIV 277
Cdd:PRK09470 247 LSDISHELRTPLTRL------------------QLATALLrrrqgeSKELERIeteaQRLdsmINDLLVLSRNQQKNHLE 308
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 278 NEkAVEVTSLLRGILQDAEsLSAGRHQIKLNIASQDQ---LLGSEEELRSAFGNLISNAIRYTPDSGEINInweKRDGQG 354
Cdd:PRK09470 309 RE-TFKANSLWSEVLEDAK-FEAEQMGKSLTVSAPPGpwpINGNPNALASALENIVRNALRYSHTKIEVAF---SVDKDG 383
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 503732216 355 LFF-VQDSGIGIEPEHIPRLTERFYRVDSSRSRETGGTGLGLAIVKHVLSRHQARMEIT-SQVGkGSRFTIWFP 426
Cdd:PRK09470 384 LTItVDDDGPGVPEEEREQIFRPFYRVDEARDRESGGTGLGLAIVENAIQQHRGWVKAEdSPLG-GLRLTIWLP 456
|
|
| AdeS_HK |
NF012226 |
two-component sensor histidine kinase AdeS; Mutations in this component of the two-component ... |
212-427 |
3.86e-24 |
|
two-component sensor histidine kinase AdeS; Mutations in this component of the two-component regulatory system for the AdeABC efflux pump can confer adaptive resistance to certain antibiotics, including tigecycline.
Pssm-ID: 411090 [Multi-domain] Cd Length: 353 Bit Score: 102.77 E-value: 3.86e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 212 ANVSHELRTPLTVISGFLETLsadenVNSGFNKRALVLMS--EQTTRMQRLIEDLLILSRLENEQSIVNEKAVEVTSLLR 289
Cdd:NF012226 143 AAIAHELRTPITILQGRLQGI-----LDGVFEPDPALFKSllNQVEGLSHLVEDLRTLSLVENQQLRLNYESVDLKDSIE 217
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 290 GILQD-AESLSAGRHQIKLNIaSQDQLLGSEEELRSAFGNLISNAIRYTpDSGEININWEKRDGQGLFFVQDSGIGIEPE 368
Cdd:NF012226 218 KVLKMfEDRLEQAQLTIVLNL-TATPVFCDRRRIEQVLIALIDNAIRYA-NAGKLKISSSVIQDDWILQIEDEGPGIAEE 295
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 503732216 369 HIPRLTERFYRVDSSRSRETGGTGLGLAIVKHVLSRHQARMEITSQVGkGSRFTIWFPA 427
Cdd:NF012226 296 YQQDLFNPFFRLEQSRNKEFGGTGLGLAVVHAIVIAHKGSIEYSNSQG-NSVFTIKLPA 353
|
|
| TMAO_torS |
TIGR02956 |
TMAO reductase sytem sensor TorS; This protein, TorS, is part of a regulatory system for the ... |
210-425 |
1.12e-23 |
|
TMAO reductase sytem sensor TorS; This protein, TorS, is part of a regulatory system for the torCAD operon that encodes the pterin molybdenum cofactor-containing enzyme trimethylamine-N-oxide (TMAO) reductase (TorA), a cognate chaperone (TorD), and a penta-haem cytochrome (TorC). TorS works together with the inducer-binding protein TorT and the response regulator TorR. TorS contains histidine kinase ATPase (pfam02518), HAMP (pfam00672), phosphoacceptor (pfam00512), and phosphotransfer (pfam01627) domains and a response regulator receiver domain (pfam00072). [Signal transduction, Two-component systems]
Pssm-ID: 274362 [Multi-domain] Cd Length: 968 Bit Score: 104.09 E-value: 1.12e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 210 FIANVSHELRTPLTVISGFLETLsADENVNSGfNKRALVLMSEQTTRMQRLIEDLLILSRLENEQSIVNEKAVEVTSLLR 289
Cdd:TIGR02956 467 FLATMSHEIRTPLNGILGTLELL-GDTGLTSQ-QQQYLQVINRSGESLLDILNDILDYSKIEAGHLSISPRPFDLNALLD 544
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 290 GILQDAESLSAGRH-QIKLNIASQ--DQLLGSEEELRSAFGNLISNAIRYTpDSGEININWEKRDGQGLFF-VQDSGIGI 365
Cdd:TIGR02956 545 DVHHLMVSRAQLKGiQLRLNIPEQlpNWWQGDGPRIRQVLINLVGNAIKFT-DRGSVVLRVSLNDDSSLLFeVEDTGCGI 623
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 366 EPEHIPRLTERFYRVDSSRSreTGGTGLGLAIVKHVLSRHQARMEITSQVGKGSRFtiWF 425
Cdd:TIGR02956 624 AEEEQATLFDAFTQADGRRR--SGGTGLGLAISQRLVEAMDGELGVESELGVGSCF--WF 679
|
|
| HATPase_BaeS-like |
cd16946 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
319-426 |
2.17e-23 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.
Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 94.07 E-value: 2.17e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 319 EEELRSAFGNLISNAIRYTPDSGEININWEKRDGQGLFFVQDSGIGIEPEHIPRLTERFYRVDSSRSRETGGTGLGLAIV 398
Cdd:cd16946 2 RDRLQQLFVNLLENSLRYTDTGGKLRIRAAQTPQEVRLDVEDSAPGVSDDQLARLFERFYRVESSRNRASGGSGLGLAIC 81
|
90 100
....*....|....*....|....*....
gi 503732216 399 KHVLSRHQARMEIT-SQVGkGSRFTIWFP 426
Cdd:cd16946 82 HNIALAHGGTISAEhSPLG-GLRLVLTLP 109
|
|
| HATPase_FilI-like |
cd16921 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
322-426 |
8.79e-23 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 92.39 E-value: 8.79e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 322 LRSAFGNLISNAIRYT--PDSGEININWEKRDGQGLFFVQDSGIGIEPEHIPRLTERFYRVDSSRsrETGGTGLGLAIVK 399
Cdd:cd16921 1 LGQVLTNLLGNAIKFRrpRRPPRIEVGAEDVGEEWTFYVRDNGIGIDPEYAEKVFGIFQRLHSRE--EYEGTGVGLAIVR 78
|
90 100
....*....|....*....|....*..
gi 503732216 400 HVLSRHQARMEITSQVGKGSRFTIWFP 426
Cdd:cd16921 79 KIIERHGGRIWLESEPGEGTTFYFTLP 105
|
|
| HATPase_BasS-like |
cd16940 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
322-425 |
1.04e-22 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.
Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 92.47 E-value: 1.04e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 322 LRSAFGNLISNAIRYTPDSGEININWEKRDGqGLFFVQDSGIGIEPEHIPRLTERFYRVDSsrsRETGGTGLGLAIVKHV 401
Cdd:cd16940 14 LFLLLRNLVDNAVRYSPQGSRVEIKLSADDG-AVIRVEDNGPGIDEEELEALFERFYRSDG---QNYGGSGLGLSIVKRI 89
|
90 100
....*....|....*....|....
gi 503732216 402 LSRHQARMEITSQVGKGSRFTIWF 425
Cdd:cd16940 90 VELHGGQIFLGNAQGGGLEAWVRL 113
|
|
| envZ |
PRK09467 |
osmolarity sensor protein; Provisional |
207-429 |
3.70e-22 |
|
osmolarity sensor protein; Provisional
Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 98.06 E-value: 3.70e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 207 RRDFIANVSHELRTPLTVISGFLETLS-ADENVNSGFNKralvlmseQTTRMQRLIEDLLILSRLENEQSIvneKAVEVT 285
Cdd:PRK09467 229 RTLLMAGVSHDLRTPLTRIRLATEMMSeEDGYLAESINK--------DIEECNAIIEQFIDYLRTGQEMPM---EMADLN 297
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 286 SLLRGILQdAESlsaGR-HQIKLNIA-SQDQLLGSEEELRSAFGNLISNAIRYTpdSGEININwEKRDGQGLFF-VQDSG 362
Cdd:PRK09467 298 ALLGEVIA-AES---GYeREIETALQpGPIEVPMNPIAIKRALANLVVNAARYG--NGWIKVS-SGTEGKRAWFqVEDDG 370
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 503732216 363 IGIEPEHIPRLTERFYRVDSSRSREtgGTGLGLAIVKHVLSRHQARMEITSQVGKGSRFTIWFPAKR 429
Cdd:PRK09467 371 PGIPPEQLKHLFQPFTRGDSARGSS--GTGLGLAIVKRIVDQHNGKVELGNSEEGGLSARAWLPLTT 435
|
|
| PRK10337 |
PRK10337 |
sensor protein QseC; Provisional |
200-418 |
8.67e-22 |
|
sensor protein QseC; Provisional
Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 97.03 E-value: 8.67e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 200 FEKIETM---RRDFIANVSHELRTPLTVISGFLET--LSADENVnsgFNKRALVLMSEQTTRMQRLIEDLLILSRLENEQ 274
Cdd:PRK10337 227 FARTHAMmvrERRFTSDAAHELRSPLAALKVQTEVaqLSDDDPQ---ARKKALLQLHAGIDRATRLVDQLLTLSRLDSLD 303
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 275 SIVNEKAVEVTSLLRGILQDAESLS-AGRHQIKLNIASQDQLLGSEEELRSAF-GNLISNAIRYTPDSGEININWEKRdg 352
Cdd:PRK10337 304 NLQDVAEIPLEDLLQSAVMDIYHTAqQAGIDVRLTLNAHPVIRTGQPLLLSLLvRNLLDNAIRYSPQGSVVDVTLNAR-- 381
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 503732216 353 qgLFFVQDSGIGIEPEHIPRLTERFYRvdsSRSRETGGTGLGLAIVKHVLSRHQARMEITSQVGKG 418
Cdd:PRK10337 382 --NFTVRDNGPGVTPEALARIGERFYR---PPGQEATGSGLGLSIVRRIAKLHGMNVSFGNAPEGG 442
|
|
| HATPase_TutC-TodS-like |
cd16925 |
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ... |
328-426 |
4.65e-21 |
|
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.
Pssm-ID: 340402 [Multi-domain] Cd Length: 110 Bit Score: 87.93 E-value: 4.65e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 328 NLISNAIRYTPDSGEININWEKRDGQG-LFFVQDSGIGIEPEHIPRLTERFYRVDSSRSRETGGTGLGLAIVKHVLSRHQ 406
Cdd:cd16925 11 NLLSNAFKFTPDGGRIRCILEKFRLNRfLLTVSDSGPGIPPNLREEIFERFRQGDGSSTRAHGGTGLGLSIVKEFVELHG 90
|
90 100
....*....|....*....|
gi 503732216 407 ARMEITSQVGKGSRFTIWFP 426
Cdd:cd16925 91 GTVTVSDAPGGGALFQVELP 110
|
|
| PRK10755 |
PRK10755 |
two-component system sensor histidine kinase PmrB; |
204-427 |
6.31e-21 |
|
two-component system sensor histidine kinase PmrB;
Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 93.49 E-value: 6.31e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 204 ETMRRD--FIANVSHELRTPLTVISGFLETLSADENVNSGfnkrALVlmsEQTTRMQRLIEDLLILSRLENEQSIVNEKA 281
Cdd:PRK10755 132 STLDQErlFTADVAHELRTPLAGIRLHLELLEKQHHIDVA----PLI---ARLDQMMHTVEQLLQLARAGQSFSSGHYQT 204
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 282 VEVTSLLRGILQD--AESLSAGRHQIKLNIASQD-QLLGSEEELRSAFGNLISNAIRYTPDSGEININWEKRDGQGLFFV 358
Cdd:PRK10755 205 VKLLEDVILPSQDelSEMLEQRQQTLLLPESAADiTVQGDATLLRLLLRNLVENAHRYSPEGSTITIKLSQEDGGAVLAV 284
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 359 QDSGIGIEPEHIPRLTERFYRVDSsrsrETGGTGLGLAIVKHVLSRHQARMEITS-QVGKGSRFTIWFPA 427
Cdd:PRK10755 285 EDEGPGIDESKCGELSKAFVRMDS----RYGGIGLGLSIVSRITQLHHGQFFLQNrQERSGTRAWVWLPK 350
|
|
| PRK10841 |
PRK10841 |
two-component system sensor histidine kinase RcsC; |
210-426 |
6.73e-21 |
|
two-component system sensor histidine kinase RcsC;
Pssm-ID: 182772 [Multi-domain] Cd Length: 924 Bit Score: 95.43 E-value: 6.73e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 210 FIANVSHELRTPLTVISGFLETLSADEnVNSGFNkRALVLMSEQTTRMQRLIEDLLILSRLENEQSIVNEK---AVEVTS 286
Cdd:PRK10841 450 FLATVSHELRTPLYGIIGNLDLLQTKE-LPKGVD-RLVTAMNNSSSLLLKIISDILDFSKIESEQLKIEPRefsPREVIN 527
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 287 llrGILQDAESLSAgRHQIKLN--IASQ--DQLLGSEEELRSAFGNLISNAIRYTpDSGEININWEKRDGQGLFFVQDSG 362
Cdd:PRK10841 528 ---HITANYLPLVV-KKRLGLYcfIEPDvpVALNGDPMRLQQVISNLLSNAIKFT-DTGCIVLHVRVDGDYLSFRVRDTG 602
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 503732216 363 IGIEPEHIPRLTERFYRVDSSRSRETGGTGLGLAIVKHVLSRHQARMEITSQVGKGSRFTIWFP 426
Cdd:PRK10841 603 VGIPAKEVVRLFDPFFQVGTGVQRNFQGTGLGLAICEKLINMMDGDISVDSEPGMGSQFTIRIP 666
|
|
| PRK09303 |
PRK09303 |
histidine kinase; |
211-422 |
2.89e-20 |
|
histidine kinase;
Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 91.94 E-value: 2.89e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 211 IANVSHELRTPLTVISGFLETLSADENVNSGFNKRALV-----LMSEQTTRMQRLIEDLLILSRLENEQSIVNEKAVEVT 285
Cdd:PRK09303 155 LAMLAHDLRTPLTAASLALETLELGQIDEDTELKPALIeqlqdQARRQLEEIERLITDLLEVGRTRWEALRFNPQKLDLG 234
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 286 SLLRGILQDAESLSAGRHQ-IKLNIAsQD--QLLGSEEELRSAFGNLISNAIRYTPDSGEININWEKRDGQGL-FFVQDS 361
Cdd:PRK09303 235 SLCQEVILELEKRWLAKSLeIQTDIP-SDlpSVYADQERIRQVLLNLLDNAIKYTPEGGTITLSMLHRTTQKVqVSICDT 313
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 503732216 362 GIGIEPEHIPRLTERFYRVdsSRSRETGGTGLGLAIVKHVLSRHQARMEITSQVGKGSRFT 422
Cdd:PRK09303 314 GPGIPEEEQERIFEDRVRL--PRDEGTEGYGIGLSVCRRIVRVHYGQIWVDSEPGQGSCFH 372
|
|
| PRK11107 |
PRK11107 |
hybrid sensory histidine kinase BarA; Provisional |
209-425 |
5.25e-20 |
|
hybrid sensory histidine kinase BarA; Provisional
Pssm-ID: 236848 [Multi-domain] Cd Length: 919 Bit Score: 92.99 E-value: 5.25e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 209 DFIANVSHELRTPLT-VIsgfletlsadenvnsGFNKRAL--VLMSEQTTRMQ----------RLIEDLLILSRLENEQs 275
Cdd:PRK11107 295 EFLANMSHELRTPLNgVI---------------GFTRQTLktPLTPTQRDYLQtiersannllAIINDILDFSKLEAGK- 358
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 276 IVNEKaveVTSLLRGILQDAESLSAGRHQIK-----LNIASQ--DQLLGSEEELRSAFGNLISNAIRYTpDSGEININWE 348
Cdd:PRK11107 359 LVLEN---IPFSLRETLDEVVTLLAHSAHEKgleltLNIDPDvpDNVIGDPLRLQQIITNLVGNAIKFT-ESGNIDILVE 434
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 349 KRDGQG-----LFFVQDSGIGIEPEHIPRLTERFYRVDSSRSRETGGTGLGLAIVKHVLSRHQARMEITSQVGKGSRFti 423
Cdd:PRK11107 435 LRALSNtkvqlEVQIRDTGIGISERQQSQLFQAFRQADASISRRHGGTGLGLVITQKLVNEMGGDISFHSQPNRGSTF-- 512
|
..
gi 503732216 424 WF 425
Cdd:PRK11107 513 WF 514
|
|
| PRK10364 |
PRK10364 |
two-component system sensor histidine kinase ZraS; |
192-428 |
1.02e-19 |
|
two-component system sensor histidine kinase ZraS;
Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 91.00 E-value: 1.02e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 192 LISRDITRFEKIETMRrDFIANVSHELRTPLTVISGFLETLSadENVNSGFNKRALV-LMSEQTTRMQRLIEDLLILSRl 270
Cdd:PRK10364 223 LLQDEMKRKEKLVALG-HLAAGVAHEIRNPLSSIKGLAKYFA--ERAPAGGEAHQLAqVMAKEADRLNRVVSELLELVK- 298
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 271 eneQSIVNEKAVEVTSL----LRGILQDAESLSAgrhQIKLNIASQDQLLGSE-EELRSAFGNLISNAIRYTPDSGEINI 345
Cdd:PRK10364 299 ---PTHLALQAVDLNDLinhsLQLVSQDANSREI---QLRFTANDTLPEIQADpDRLTQVLLNLYLNAIQAIGQHGVISV 372
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 346 NWEKRDGQGLFFVQDSGIGIEPEHIPRLTERFYrvdssrSRETGGTGLGLAIVKHVLSRHQARMEITSQVGKGSRFTIWF 425
Cdd:PRK10364 373 TASESGAGVKISVTDSGKGIAADQLEAIFTPYF------TTKAEGTGLGLAVVHNIVEQHGGTIQVASQEGKGATFTLWL 446
|
...
gi 503732216 426 PAK 428
Cdd:PRK10364 447 PVN 449
|
|
| HATPase_BceS-YxdK-YvcQ-like |
cd16948 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
322-426 |
1.54e-19 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.
Pssm-ID: 340424 [Multi-domain] Cd Length: 109 Bit Score: 83.49 E-value: 1.54e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 322 LRSAFGNLISNAIRYTPDSGEININWEKRDGQGLFFVQDSGIGIEPEHIPRLTERFYRVDSSRsRETGGTGLGLAIVKHV 401
Cdd:cd16948 6 LSFIIGQIVSNALKYSKQGGKIEIYSETNEQGVVLSIKDFGIGIPEEDLPRVFDKGFTGENGR-NFQESTGMGLYLVKKL 84
|
90 100
....*....|....*....|....*
gi 503732216 402 LSRHQARMEITSQVGKGSRFTIWFP 426
Cdd:cd16948 85 CDKLGHKIDVESEVGEGTTFTITFP 109
|
|
| HATPase_EnvZ-like |
cd16950 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
322-426 |
2.85e-19 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.
Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 82.50 E-value: 2.85e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 322 LRSAFGNLISNAIRYTpdSGEININWEKRDGQGLFFVQDSGIGIEPEHIPRLTERFYRVDSSRSreTGGTGLGLAIVKHV 401
Cdd:cd16950 1 LKRVLSNLVDNALRYG--GGWVEVSSDGEGNRTRIQVLDNGPGIAPEEVDELFQPFYRGDNARG--TSGTGLGLAIVQRI 76
|
90 100
....*....|....*....|....*
gi 503732216 402 LSRHQARMEITSQVGKGSRFTIWFP 426
Cdd:cd16950 77 SDAHGGSLTLANRAGGGLCARIELP 101
|
|
| PRK11091 |
PRK11091 |
aerobic respiration control sensor protein ArcB; Provisional |
195-427 |
1.10e-18 |
|
aerobic respiration control sensor protein ArcB; Provisional
Pssm-ID: 236842 [Multi-domain] Cd Length: 779 Bit Score: 88.84 E-value: 1.10e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 195 RDIT---RF-EKIETMRRD---FIANVSHELRTPLTVISGfletLSadenvnsgfnkRALV---LMSEQTTRMQ------ 258
Cdd:PRK11091 264 RDITerkRYqDALEKASRDkttFISTISHELRTPLNGIVG----LS-----------RILLdteLTAEQRKYLKtihvsa 328
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 259 ----RLIEDLLILSRLENEQSIVNEKAVEVTSLLrgilQDAESLS---AGRHQIKLNIASQ----DQLLGSEEELRSAFG 327
Cdd:PRK11091 329 itlgNIFNDIIDMDKMERRKLQLDNQPIDFTDFL----ADLENLSglqAEQKGLRFDLEPLlplpHKVITDGTRLRQILW 404
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 328 NLISNAIRYTPDsGEININWEKRDGQGLFF-VQDSGIGIEPEHIPRLTERFYRV-DSSRSRETGGTGLGLAIVKHVLSRH 405
Cdd:PRK11091 405 NLISNAVKFTQQ-GGVTVRVRYEEGDMLTFeVEDSGIGIPEDELDKIFAMYYQVkDSHGGKPATGTGIGLAVSKRLAQAM 483
|
250 260
....*....|....*....|..
gi 503732216 406 QARMEITSQVGKGSRFTIWFPA 427
Cdd:PRK11091 484 GGDITVTSEEGKGSCFTLTIHA 505
|
|
| marine_sort_HK |
TIGR03785 |
proteobacterial dedicated sortase system histidine kinase; This histidine kinase protein is ... |
208-426 |
1.61e-18 |
|
proteobacterial dedicated sortase system histidine kinase; This histidine kinase protein is paired with an adjacent response regulator (TIGR03787) gene. It co-occurs with a variant sortase enzyme (TIGR03784), usually in the same gene neighborhood, in proteobacterial species most of which are marine, and with an LPXTG motif-containing sortase target conserved protein (TIGR03788). Sortases and LPXTG proteins are far more common in Gram-positive bacteria, where sortase systems mediate attachment to the cell wall or cross-linking of pilin structures. We give this predicted sensor histidine kinase the gene symbol psdS, for Proteobacterial Dedicated Sortase system Sensor histidine kinase.
Pssm-ID: 163497 [Multi-domain] Cd Length: 703 Bit Score: 88.26 E-value: 1.61e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 208 RDFIANVSHELRTPLTVISGFLETLS--ADENVNSGFNKRAlvlmSEQTTRMQRLIEDLLILSRLenEQSIV-NEK-AVE 283
Cdd:TIGR03785 486 ENMSSRLSHELRTPVAVVRSSLENLElqALEQEKQKYLERA----REGTERLSMILNNMSEATRL--EQAIQsAEVeDFD 559
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 284 VTSLLRGILQDAESLSAGrHQIKLNIASQDQLL-GSEEELRSAFGNLISNAIRYTPDSGEININWEKRDGQGLFFVQDSG 362
Cdd:TIGR03785 560 LSEVLSGCMQGYQMTYPP-QRFELNIPETPLVMrGSPELIAQMLDKLVDNAREFSPEDGLIEVGLSQNKSHALLTVSNEG 638
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 503732216 363 IGIePEHIP-RLTERFYRVDSSRSRETGGTGLGLAIVKHVLSRHQARMEITSQV-GKGSRFTIWFP 426
Cdd:TIGR03785 639 PPL-PEDMGeQLFDSMVSVRDQGAQDQPHLGLGLYIVRLIADFHQGRIQAENRQqNDGVVFRISLP 703
|
|
| PRK11466 |
PRK11466 |
hybrid sensory histidine kinase TorS; Provisional |
201-432 |
5.99e-18 |
|
hybrid sensory histidine kinase TorS; Provisional
Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 86.50 E-value: 5.99e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 201 EKIETMRRDFIANVSHELRTPLTVISGFLETLSadENVNSGFNKRALVLMSEQTTRMQRLIEDLLILSRLE--NEQSIVN 278
Cdd:PRK11466 438 EKASQAKSAFLAAMSHEIRTPLYGILGTAQLLA--DNPALNAQRDDLRAITDSGESLLTILNDILDYSAIEagGKNVSVS 515
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 279 EKAVEVTSLLRGILQDAESLSAGRhQIKLNIASQDQ----LLGSEEELRSAFGNLISNAIRYTpDSGEININWEKRDGQG 354
Cdd:PRK11466 516 DEPFEPRPLLESTLQLMSGRVKGR-PIRLATDIADDlptaLMGDPRRIRQVITNLLSNALRFT-DEGSIVLRSRTDGEQW 593
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 503732216 355 LFFVQDSGIGIEPEHIPRLTERFYRVDSSRsretGGTGLGLAIVKHVLSRHQARMEITSQVGKGSRFTIWFPAKRLIP 432
Cdd:PRK11466 594 LVEVEDSGCGIDPAKLAEIFQPFVQVSGKR----GGTGLGLTISSRLAQAMGGELSATSTPEVGSCFCLRLPLRVATA 667
|
|
| PRK15347 |
PRK15347 |
two component system sensor kinase; |
211-432 |
1.59e-17 |
|
two component system sensor kinase;
Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 85.08 E-value: 1.59e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 211 IANVSHELRTPLTVISGFLETLSADENVNSgfnKRALVLMSEQTTR-MQRLIEDLLILSRLENEQSIVNekaVEVTSLLR 289
Cdd:PRK15347 402 LTTISHEIRTPLNGVLGALELLQNTPLTAE---QMDLADTARQCTLsLLAIINNLLDFSRIESGQMTLS---LEETALLP 475
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 290 gILQDAESLSAGRHQIK-LN---IASQD---QLLGSEEELRSAFGNLISNAIRYTPDsGEININWEKRDGQGLFFVQDSG 362
Cdd:PRK15347 476 -LLDQAMLTIQGPAQSKsLTlrtFVGAHvplYLHLDSLRLRQILVNLLGNAVKFTET-GGIRLRVKRHEQQLCFTVEDTG 553
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 363 IGIEPEHIPRLTERFYRVDSSrsreTGGTGLGLAIVKHVLSRHQARMEITSQVGKGSRFTIWFPAKRLIP 432
Cdd:PRK15347 554 CGIDIQQQQQIFTPFYQADTH----SQGTGLGLTIASSLAKMMGGELTLFSTPGVGSCFSLVLPLNEYAP 619
|
|
| HATPase_RstB-like |
cd16939 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
325-427 |
1.60e-16 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.
Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 74.77 E-value: 1.60e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 325 AFGNLISNAIRYTpdSGEININWEKRDGQGLFFVQDSGIGIEPEHIPRLTERFYRVDSSRSRETGGTGLGLAIVKHVLSR 404
Cdd:cd16939 4 ALDNLLRNALRYA--HRTVRIALLVSGGRLTLIVEDDGPGIPAAARERVFEPFVRLDPSRDRATGGFGLGLAIVHRVALW 81
|
90 100
....*....|....*....|...
gi 503732216 405 HQARMEITSQVGKGSRFTIWFPA 427
Cdd:cd16939 82 HGGHVECDDSELGGACFRLTWPR 104
|
|
| PRK10490 |
PRK10490 |
sensor protein KdpD; Provisional |
204-433 |
1.85e-16 |
|
sensor protein KdpD; Provisional
Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 82.01 E-value: 1.85e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 204 ETMRRDFIANVSHELRTPLTVISGFLETLSAD-ENVNSGFNKRAlVLMSEQTTRMQRLIEDLLILSRLENEQSIVNEKAV 282
Cdd:PRK10490 661 EQLRNALLAALSHDLRTPLTVLFGQAEILTLDlASEGSPHARQA-SEIRQQVLNTTRLVNNLLDMARIQSGGFNLRKEWL 739
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 283 EVTSLLRGILQDAESlSAGRHQIKLNIASQDQLLGSEEEL-RSAFGNLISNAIRYTPDSGEININWEKRDGQGLFFVQDS 361
Cdd:PRK10490 740 TLEEVVGSALQMLEP-GLSGHPINLSLPEPLTLIHVDGPLfERVLINLLENAVKYAGAQAEIGIDAHVEGERLQLDVWDN 818
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 503732216 362 GIGIEPEHIPRLTERFYRVDSSRSreTGGTGLGLAIVKHVLSRHQARMEITSQVGKGSRFTIWFPAKRLiPE 433
Cdd:PRK10490 819 GPGIPPGQEQLIFDKFARGNKESA--IPGVGLGLAICRAIVEVHGGTIWAENRPEGGACFRVTLPLETP-PE 887
|
|
| HisKA |
pfam00512 |
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ... |
206-273 |
1.99e-16 |
|
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.
Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 73.40 E-value: 1.99e-16
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 503732216 206 MRRDFIANVSHELRTPLTVISGFLETLSadENVNSGFNKRALVLMSEQTTRMQRLIEDLLILSRLENE 273
Cdd:pfam00512 1 AKSEFLANLSHELRTPLTAIRGYLELLR--DEKLDEEQREYLETILRSAERLLRLINDLLDLSRIEAG 66
|
|
| PRK09959 |
PRK09959 |
acid-sensing system histidine kinase EvgS; |
207-428 |
6.90e-16 |
|
acid-sensing system histidine kinase EvgS;
Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 80.16 E-value: 6.90e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 207 RRDFIANVSHELRTPLTVISGFLETLSAdenvnSGFNK----RALVLMSEQTTRMQRLIEDLLILSRLENEQSIVNEKAV 282
Cdd:PRK09959 712 KSQFLATMSHEIRTPISSIMGFLELLSG-----SGLSKeqrvEAISLAYATGQSLLGLIGEILDVDKIESGNYQLQPQWV 786
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 283 EVTSLLRGILQDAESLSAGRhQIKLNIASQ--DQLLGS--EEELRSAFGNLISNAIRYTPDsGEININWEK---RDGQGL 355
Cdd:PRK09959 787 DIPTLVQNTCHSFGAIAASK-SIALSCSSTfpDHYLVKidPQAFKQVLSNLLSNALKFTTE-GAVKITTSLghiDDNHAV 864
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 503732216 356 --FFVQDSGIGIEPEHIPRLTERFYRvdSSRSRETGGTGLGLAIVKHVLSRHQARMEITSQVGKGSRFTIWFPAK 428
Cdd:PRK09959 865 ikMTIMDSGSGLSQEEQQQLFKRYSQ--TSAGRQQTGSGLGLMICKELIKNMQGDLSLESHPGIGTTFTITIPVE 937
|
|
| HisKA |
cd00082 |
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ... |
204-269 |
1.18e-15 |
|
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.
Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 71.09 E-value: 1.18e-15
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 503732216 204 ETMRRDFIANVSHELRTPLTVISGFLETLsADENVNSGFNKRALVLMSEQTTRMQRLIEDLLILSR 269
Cdd:cd00082 1 LQAKGEFLANVSHELRTPLTAIRGALELL-EEELLDDEEQREYLERIREEAERLLRLINDLLDLSR 65
|
|
| HisKA |
smart00388 |
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ... |
206-273 |
1.31e-15 |
|
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.
Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 71.06 E-value: 1.31e-15
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 503732216 206 MRRDFIANVSHELRTPLTVISGFLETLSADEnvNSGFNKRALVLMSEQTTRMQRLIEDLLILSRLENE 273
Cdd:smart00388 1 AKREFLANLSHELRTPLTAIRGYLELLLDTE--LSEEQREYLETILREAERLLRLINDLLDLSRIEAG 66
|
|
| HATPase_AtoS-like |
cd16943 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
320-426 |
1.79e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.
Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 72.07 E-value: 1.79e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 320 EELRSAFGNLISNAIRYTPDSGEININWEKRDGQGLFFVQDSGIGIEPEHIPRLTERFYRvdssrSRETG-GTGLGLAIV 398
Cdd:cd16943 2 SQLNQVLLNLLVNAAQAMEGRGRITIRTWAHVDQVLIEVEDTGSGIDPEILGRIFDPFFT-----TKPVGeGTGLGLSLS 76
|
90 100
....*....|....*....|....*...
gi 503732216 399 KHVLSRHQARMEITSQVGKGSRFTIWFP 426
Cdd:cd16943 77 YRIIQKHGGTIRVASVPGGGTRFTIILP 104
|
|
| HATPase_SpaK_NisK-like |
cd16975 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
319-425 |
6.69e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.
Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 70.18 E-value: 6.69e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 319 EEELRSAFGNLISNAIRYTPDSGEININWEKRDGQGLFFVQDSGIGIEPEHIPRLTERFYRVDSSRsRETGGTGLGLAIV 398
Cdd:cd16975 2 TLLLSRALINIISNACQYAPEGGTVSISIYDEEEYLYFEIWDNGHGFSEQDLKKALELFYRDDTSR-RSGGHYGMGLYIA 80
|
90 100
....*....|....*....|....*..
gi 503732216 399 KHVLSRHQARMEITSQVGKGSRFTIWF 425
Cdd:cd16975 81 KNLVEKHGGSLIIENSQKGGAEVTVKI 107
|
|
| HATPase_CreC-like |
cd16945 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
322-411 |
8.75e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.
Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 70.18 E-value: 8.75e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 322 LRSAFGNLISNAIRYTPDSGEININWEKRDGQGLFFVQDSGIGIEPEHIPRLTERFYrvdsSRSRETGG---TGLGLAIV 398
Cdd:cd16945 5 LRQAINNLLDNAIDFSPEGGLIALQLEADTEGIELLVFDEGSGIPDYALNRVFERFY----SLPRPHSGqksTGLGLAFV 80
|
90
....*....|...
gi 503732216 399 KHVLSRHQARMEI 411
Cdd:cd16945 81 QEVAQLHGGRITL 93
|
|
| PRK13837 |
PRK13837 |
two-component system VirA-like sensor kinase; |
199-426 |
1.07e-14 |
|
two-component system VirA-like sensor kinase;
Pssm-ID: 237526 [Multi-domain] Cd Length: 828 Bit Score: 76.25 E-value: 1.07e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 199 RFEKIETmrrdFIANVSHELRTPLTVISGFLETlsADENVNSGFNKRA-LVLMSEQTTRMQRLIEDLLILSRLENEqsiv 277
Cdd:PRK13837 446 RLEAVGT----LASGIAHNFNNILGAILGYAEM--ALNKLARHSRAARyIDEIISAGARARLIIDQILAFGRKGER---- 515
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 278 NEKAVEVTSLLRGIlqdAESLSA--GRHqIKLNIaSQDQ----LLGSEEELRSAFGNLISNAIRYTPDSGEININWEKRD 351
Cdd:PRK13837 516 NTKPFDLSELVTEI---APLLRVslPPG-VELDF-DQDQepavVEGNPAELQQVLMNLCSNAAQAMDGAGRVDISLSRAK 590
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 352 GQG---------------LFFVQDSGIGIEPEHIPRLTERFYrvdSSRSretGGTGLGLAIVKHVLSRHQARMEITSQVG 416
Cdd:PRK13837 591 LRApkvlshgvlppgryvLLRVSDTGAGIDEAVLPHIFEPFF---TTRA---GGTGLGLATVHGIVSAHAGYIDVQSTVG 664
|
250
....*....|
gi 503732216 417 KGSRFTIWFP 426
Cdd:PRK13837 665 RGTRFDVYLP 674
|
|
| HATPase_VanS-like |
cd16923 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
322-426 |
4.16e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.
Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 67.80 E-value: 4.16e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 322 LRSAFGNLISNAIRYTPDSGEININWEKRDGQGLFFVQDSGIGIEPEHIPRLTERFYRVDSSRsrETGGTGLGLAIVKHV 401
Cdd:cd16923 1 LQRVFSNLLSNAIKYSPENTRIYITSFLTDDVVNIMFKNPSSHPLDFKLEKLFERFYRGDNSR--NTEGAGLGLSIAKAI 78
|
90 100
....*....|....*....|....*
gi 503732216 402 LSRHQARMEITSQvGKGSRFTIWFP 426
Cdd:cd16923 79 IELHGGSASAEYD-DNHDLFKVRLP 102
|
|
| PhoR |
pfam11808 |
Phosphate regulon sensor protein PhoR; This family is only found in bacteria. Family members ... |
19-91 |
5.46e-13 |
|
Phosphate regulon sensor protein PhoR; This family is only found in bacteria. Family members include PhoR. A member of the two-component regulatory system PhoR/PhoB involved in the phosphate regulon genes expression. PhoR is the bifunctional histidine autokinase/phospho-PhoB phosphatase that donates a phosphoryl group to PhoB when environmental Pi is limiting and removes the phosphoryl group from phosphorylated PhoB (PhoB-P) when environmental Pi is abundant.
Pssm-ID: 432090 Cd Length: 84 Bit Score: 64.16 E-value: 5.46e-13
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 503732216 19 AVLWMIFGAVKALLFFGvvMLWIAFHHIRYLAALERWLRlsDHSPASIPAGSGAWDDVFAHLARYVRQHSQSQ 91
Cdd:pfam11808 16 LLLGLLFGHLAAALLLA--LLAYLAWHLYQLLRLSRWLW--RPRKLTPPDGSGLWGEIFYGLYRLQRRNRRRR 84
|
|
| HATPase_YcbM-like |
cd16947 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
316-423 |
9.01e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).
Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 62.15 E-value: 9.01e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 316 LGSEEELRSAFGNLISNAIRYTPDSGEININWEKRDGQGLFFVQDSGIGIEPEHIPRLTERFYRVDSSRSRETGGTGLGL 395
Cdd:cd16947 15 NANTEALQRILKNLISNAIKYGSDGKFLGMTLREDEKHVYIDIWDKGKGISETEKDHVFERLYTLEDSRNSAKQGNGLGL 94
|
90 100
....*....|....*....|....*...
gi 503732216 396 AIVKHVLSRHQARMEITSQVGKGSRFTI 423
Cdd:cd16947 95 TITKRLAESMGGSIYVNSKPYEKTVFTV 122
|
|
| HATPase_PhoQ-like |
cd16954 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
304-425 |
2.70e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.
Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 61.11 E-value: 2.70e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 304 QIKLNIASQDQLLGSEEELRSAFGNLISNAIRYTpdSGEININWEKRDGQGLFFVQDSGIGIEPEHIPRLTERFYRVDSS 383
Cdd:cd16954 20 SISLDISPELRFPGERNDLMELLGNLLDNACKWC--LEFVEVTARQTDGGLHLIVDDDGPGVPESQRSKIFQRGQRLDEQ 97
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 503732216 384 RSretgGTGLGLAIVKHVLSRHQARMEITSQVGKGSRFTIWF 425
Cdd:cd16954 98 RP----GQGLGLAIAKEIVEQYGGELSLSDSPLGGARFEVVF 135
|
|
| HATPase_HupT_MifS-like |
cd16976 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
328-423 |
3.94e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.
Pssm-ID: 340435 [Multi-domain] Cd Length: 102 Bit Score: 56.70 E-value: 3.94e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 328 NLISNAIRYTPD--SGEININWEKRDGQGLFFVQDSGIGIEPEHIPRLTERFYRvdssrSRETG-GTGLGLAIVKHVLSR 404
Cdd:cd16976 7 NLLQNALDAMGKveNPRIRIAARRLGGRLVLVVRDNGPGIAEEHLSRVFDPFFT-----TKPVGkGTGLGLSISYGIVEE 81
|
90
....*....|....*....
gi 503732216 405 HQARMEITSQVGKGSRFTI 423
Cdd:cd16976 82 HGGRLSVANEEGAGARFTF 100
|
|
| PRK10618 |
PRK10618 |
phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional |
85-434 |
3.99e-10 |
|
phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional
Pssm-ID: 236726 [Multi-domain] Cd Length: 894 Bit Score: 61.87 E-value: 3.99e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 85 RQHSQSQELLSLALERMRS----VTSAMPDGIVILD-ETDRIEWCNPVAEqHLGINLSLdtgQQITYLVRQipfveylaa 159
Cdd:PRK10618 325 HQYGRPTESMSHELRILRAlneeIVSNLPLGLLVYDfESNRTVISNKIAD-HLLPHLNL---QKITTMAEQ--------- 391
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 160 rkysnplilnqtrQQGII-------------VSLQLVPYGY-------NQKLLISRDITR----FEKIETMRRDFIANVS 215
Cdd:PRK10618 392 -------------HQGVIqatinnelyeirmFRSQLAPRTQlfllrdqDREVLVNKKLQQaqreYEKNQQARKAFLQNIG 458
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 216 HELRTPLTVISGFLETLSADEnvNSGFNKRALVLMSEQTTRMQRLIEDLLILSRLENEQSIVNEKAVEVTSLLRGILQda 295
Cdd:PRK10618 459 DELKQPLQSLAQLAAQLRQTS--DEEQQQPELDQLAEQSDVLVRLVDNIQLLNMLETQDWKPEQELFSLQDLIDEVLP-- 534
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 296 ESLSAGRHQ-----IKLNIASQDQLLGSEEELRSAFGNLISNAIRYTpDSGEININW---EKRDGQGLFFVQDSGIGIEP 367
Cdd:PRK10618 535 EVLPAIKRKglqllIHNHLKAEQLRIGDRDALRKILLLLLNYAITTT-AYGKITLEVdqdESSPDRLTIRILDTGAGVSI 613
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 503732216 368 E-----HIPRLTE----RFYRvdssrsretgGTGLGLAIVKHVLSRHQARMEITSQVGKGSRFTIWFPAKRLIPEN 434
Cdd:PRK10618 614 KeldnlHFPFLNQtqgdRYGK----------ASGLTFFLCNQLCRKLGGHLTIKSREGLGTRYSIHLKMLAADPEV 679
|
|
| HATPase_DpiB-CitA-like |
cd16915 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
327-426 |
6.67e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.
Pssm-ID: 340392 [Multi-domain] Cd Length: 104 Bit Score: 56.14 E-value: 6.67e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 327 GNLISNAIRYTPDSGEIN--INWEKRD-GQGLFF-VQDSGIGIEPEHIPRLTERFYRvdssrSRETGGTGLGLAIVKHVL 402
Cdd:cd16915 6 GNLIDNALDALAATGAPNkqVEVFLRDeGDDLVIeVRDTGPGIAPELRDKVFERGVS-----TKGQGERGIGLALVRQSV 80
|
90 100
....*....|....*....|....
gi 503732216 403 SRHQARMEITSQVGKGSRFTIWFP 426
Cdd:cd16915 81 ERLGGSITVESEPGGGTTFSIRIP 104
|
|
| HATPase_NtrY-like |
cd16944 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
322-426 |
9.04e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.
Pssm-ID: 340420 [Multi-domain] Cd Length: 108 Bit Score: 56.01 E-value: 9.04e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 322 LRSAFGNLISNA---IRYTPDS-GEININWEK-RDGQGLFFVQDSGIGIEPEHIPRLTERfYRVDSSRsretgGTGLGLA 396
Cdd:cd16944 5 ISQVLTNILKNAaeaIEGRPSDvGEVRIRVEAdQDGRIVLIVCDNGKGFPREMRHRATEP-YVTTRPK-----GTGLGLA 78
|
90 100 110
....*....|....*....|....*....|
gi 503732216 397 IVKHVLSRHQARMEITSQVGKGSRFTIWFP 426
Cdd:cd16944 79 IVKKIMEEHGGRISLSNREAGGACIRIILP 108
|
|
| COG4192 |
COG4192 |
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ... |
214-418 |
1.12e-09 |
|
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];
Pssm-ID: 443346 [Multi-domain] Cd Length: 640 Bit Score: 60.47 E-value: 1.12e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 214 VSHELRTPLTVISGFLETLS-ADENVNSGFNKRALVLMSEQTTRMQRLIEDLLILSRLeneqsiVNEKAVEVtsLLRGIL 292
Cdd:COG4192 440 LAHELNQPLNAMSMYLFSAKkALEQENYAQLPTSLDKIEGLIERMDKIIKSLRQFSRK------SDTPLQPV--DLRQVI 511
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 293 QDAESLSAGRH---QIKLNIASQDQLLGSEEELRSAFGNLISNAIRYTPDSGEININWEKRDGQGLFFVQDSGIGIEPeh 369
Cdd:COG4192 512 EQAWELVESRAkpqQITLHIPDDLMVQGDQVLLEQVLVNLLVNALDAVATQPQISVDLLSNAENLRVAISDNGNGWPL-- 589
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 503732216 370 IPRLTERFYrvdssrSRETGGTGLGLAIVKHVLSRHQARMEITSQVGKG 418
Cdd:COG4192 590 VDKLFTPFT------TTKEVGLGLGLSICRSIMQQFGGDLYLASTLERG 632
|
|
| HATPase_CckA-like |
cd16919 |
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ... |
322-426 |
4.06e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).
Pssm-ID: 340396 [Multi-domain] Cd Length: 116 Bit Score: 54.31 E-value: 4.06e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 322 LRSAFGNLISNAIRYTPDSGEININ----WEKRDGQG-----------LFFVQDSGIGIEPEHIPRLTERFYRvdssrSR 386
Cdd:cd16919 1 LELAILNLAVNARDAMPEGGRLTIEtsnqRVDADYALnyrdlipgnyvCLEVSDTGSGMPAEVLRRAFEPFFT-----TK 75
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 503732216 387 ETG-GTGLGLAIVKHVLSRHQARMEITSQVGKGSRFTIWFP 426
Cdd:cd16919 76 EVGkGTGLGLSMVYGFVKQSGGHLRIYSEPGVGTTVRIYLP 116
|
|
| HATPase_TmoS-FixL-DctS-like |
cd16920 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
328-426 |
1.12e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 52.40 E-value: 1.12e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 328 NLISNAIR----YTPDSGEININWEKRDGQGL-FFVQDSGIGIEPEHIPRLTERFYRVDSSrsretgGTGLGLAIVKHVL 402
Cdd:cd16920 7 NLVRNGIEamseGGCERRELTIRTSPADDRAVtISVKDTGPGIAEEVAGQLFDPFYTTKSE------GLGMGLSICRSII 80
|
90 100
....*....|....*....|....
gi 503732216 403 SRHQARMEITSQVGKGSRFTIWFP 426
Cdd:cd16920 81 EAHGGRLSVESPAGGGATFQFTLP 104
|
|
| HATPase_BvrS-ChvG-like |
cd16953 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
322-426 |
1.42e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.
Pssm-ID: 340429 [Multi-domain] Cd Length: 110 Bit Score: 52.57 E-value: 1.42e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 322 LRSAFGNLISNAIRYTP-DSGEININWEKRDGQGLFFVQDSGIGIEPEHIPRLTERFYRVDSSRSRETGGTGLGLAIVKH 400
Cdd:cd16953 1 LGQVLRNLIGNAISFSPpDTGRITVSAMPTGKMVTISVEDEGPGIPQEKLESIFDRFYTERPANEAFGQHSGLGLSISRQ 80
|
90 100 110
....*....|....*....|....*....|
gi 503732216 401 VLSRH----QARMEITSQVGKGSRFTIWFP 426
Cdd:cd16953 81 IIEAHggisVAENHNQPGQVIGARFTVQLP 110
|
|
| HATPase_Glnl-NtrB-like |
cd16918 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
322-426 |
2.03e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).
Pssm-ID: 340395 [Multi-domain] Cd Length: 109 Bit Score: 52.02 E-value: 2.03e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 322 LRSAFGNLISNAIRYTPDS-GEININWE-------KRDGQGLFF---VQDSGIGIEPEHIPRLterFYRVDSSRSretGG 390
Cdd:cd16918 1 LIQVFLNLVRNAAQALAGSgGEIILRTRtqrqvtlGHPRHRLALrvsVIDNGPGIPPDLQDTI---FYPMVSGRE---NG 74
|
90 100 110
....*....|....*....|....*....|....*.
gi 503732216 391 TGLGLAIVKHVLSRHQARMEITSQVGKgSRFTIWFP 426
Cdd:cd16918 75 TGLGLAIAQNIVSQHGGVIECDSQPGH-TVFSVSLP 109
|
|
| COG3920 |
COG3920 |
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ... |
278-432 |
1.54e-07 |
|
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];
Pssm-ID: 443125 [Multi-domain] Cd Length: 495 Bit Score: 53.37 E-value: 1.54e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 278 NEKAVEVTSLLRGILQDAESlSAGRHQIKLNIASQDQLLGSEE---------ELrsafgnlISNAIRY---TPDSGEINI 345
Cdd:COG3920 355 DWEGVDLRDYLRELLEPLRD-SYGGRGIRIELDGPDVELPADAavplglilnEL-------VTNALKHaflSGEGGRIRV 426
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 346 NWEKRDGQGLFFVQDSGIGIEPEhiprlterfyrVDSSRSRetggtGLGLAIVKHVLSRHQARMEITSqvGKGSRFTIWF 425
Cdd:COG3920 427 SWRREDGRLRLTVSDNGVGLPED-----------VDPPARK-----GLGLRLIRALVRQLGGTLELDR--PEGTRVRITF 488
|
....*..
gi 503732216 426 PAKRLIP 432
Cdd:COG3920 489 PLAELAA 495
|
|
| YesM |
COG2972 |
Sensor histidine kinase YesM [Signal transduction mechanisms]; |
329-429 |
1.79e-07 |
|
Sensor histidine kinase YesM [Signal transduction mechanisms];
Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 53.10 E-value: 1.79e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 329 LISNAIRY----TPDSGEININWEKRDGQGLFFVQDSGIGIEPEHIPRLTERFyrvdssrSRETGGTGLGLAIVKHVLSR 404
Cdd:COG2972 344 LVENAIEHgiepKEGGGTIRISIRKEGDRLVITVEDNGVGMPEEKLEKLLEEL-------SSKGEGRGIGLRNVRERLKL 416
|
90 100
....*....|....*....|....*...
gi 503732216 405 H---QARMEITSQVGKGSRFTIWFPAKR 429
Cdd:COG2972 417 YygeEYGLEIESEPGEGTTVTIRIPLEE 444
|
|
| PRK11086 |
PRK11086 |
sensory histidine kinase DcuS; Provisional |
303-426 |
2.99e-07 |
|
sensory histidine kinase DcuS; Provisional
Pssm-ID: 236839 [Multi-domain] Cd Length: 542 Bit Score: 52.61 E-value: 2.99e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 303 HQIKLNIASQDQLLGSEE---ELRSAFGNLISN---AIRYTPDsGEININWEKRDGQGLFFVQDSGIGIEPEHIPRLTER 376
Cdd:PRK11086 412 ITLIISEDSQLPDSGDEDqvhELITILGNLIENaleAVGGEEG-GEISVSLHYRNGWLHCEVSDDGPGIAPDEIDAIFDK 490
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 503732216 377 FYrvdssrSRETGGTGLGLAIVKHVLSRHQARMEITSQVGKGSRFTIWFP 426
Cdd:PRK11086 491 GY------STKGSNRGVGLYLVKQSVENLGGSIAVESEPGVGTQFFVQIP 534
|
|
| PRK10815 |
PRK10815 |
two-component system sensor histidine kinase PhoQ; |
187-425 |
5.33e-07 |
|
two-component system sensor histidine kinase PhoQ;
Pssm-ID: 182754 [Multi-domain] Cd Length: 485 Bit Score: 51.56 E-value: 5.33e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 187 YNQKLLISRDITRFEKIETMrrdfIANVSHELRTPLTVISGFLETLSADENVNSgfnKRALVLMSEQTTRMQRLIEDLLI 266
Cdd:PRK10815 250 RNLNRLLKNERERYTKYRTT----LTDLTHSLKTPLAVLQSTLRSLRSGKQMSV---EQAEPIMLEQISRISQQIGYYLH 322
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 267 LSRLENEQSIVNEKAVEVTSLLrgilqdaESLSAGRHQ--------IKLNIASQDQLLGSEEELRSAFGNLISNAIRYTP 338
Cdd:PRK10815 323 RASMRSEHNLLSRELHSVAPLL-------DNLTSALNKvyqrkgvnITLDISPEITFVGEKNDFMEVMGNVLDNACKYCL 395
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 339 DSGEINInweKRDGQGL-FFVQDSGIGIEPEHIPRLTERFYRVDSSRSretgGTGLGLAIVKHVLSRHQARMEITSQVGK 417
Cdd:PRK10815 396 EFVEISA---RQTDEHLhIVVEDDGPGIPESKRELIFDRGQRADTLRP----GQGLGLSVAREITEQYEGKISAGDSPLG 468
|
....*...
gi 503732216 418 GSRFTIWF 425
Cdd:PRK10815 469 GARMEVIF 476
|
|
| glnL |
PRK11073 |
nitrogen regulation protein NR(II); |
112-428 |
5.54e-07 |
|
nitrogen regulation protein NR(II);
Pssm-ID: 182947 [Multi-domain] Cd Length: 348 Bit Score: 51.24 E-value: 5.54e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 112 IVILDETDRIEWCNPVAEQ-------------------HLGINL-----SLDTGQ-----QITYLVRQIPFVEYLAARKY 162
Cdd:PRK11073 20 ILLLDDDLAIHYANPAAQQllaqssrklfgtplpellsYFSLNIelmreSLQAGQgftdnEVTLVIDGRSHILSLTAQRL 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 163 SNPLILnqtrqqgiivsLQLVPYGyNQKLLISRDITRFEKIETmrRDFIANVSHELRTPLTVISG---FLETLSADENVN 239
Cdd:PRK11073 100 PEGMIL-----------LEMAPMD-NQRRLSQEQLQHAQQVAA--RDLVRGLAHEIKNPLGGLRGaaqLLSKALPDPALT 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 240 SgFNKralvLMSEQTTRMQRLIEDLLILSR--LENEQSI--VNEKAVEVTSL---------------LRGILQDAESLsa 300
Cdd:PRK11073 166 E-YTK----VIIEQADRLRNLVDRLLGPQRpgTHVTESIhkVAERVVQLVSLelpdnvrlirdydpsLPELAHDPDQI-- 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 301 grHQIKLNIASQD-QLLGSEeelrsafGNLISnaIRyTPDSGEININWEKRDGQGLFFVQDSGIGIEPEHIPRLterFYR 379
Cdd:PRK11073 239 --EQVLLNIVRNAlQALGPE-------GGTIT--LR-TRTAFQLTLHGERYRLAARIDIEDNGPGIPPHLQDTL---FYP 303
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 503732216 380 VDSSRSretGGTGLGLAIVKHVLSRHQARMEITSQVGKgSRFTIWFPAK 428
Cdd:PRK11073 304 MVSGRE---GGTGLGLSIARNLIDQHSGKIEFTSWPGH-TEFSVYLPIR 348
|
|
| RocR |
COG3829 |
RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis ... |
94-204 |
7.01e-07 |
|
RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis domains [Transcription, Signal transduction mechanisms];
Pssm-ID: 443041 [Multi-domain] Cd Length: 448 Bit Score: 51.31 E-value: 7.01e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 94 LSLALERMRSVTSAMPDGIVILDETDRIEWCNPVAEQHLGINLSLDTGQQITYLVRQIPFVEYLAARKYSNPLILNqTRQ 173
Cdd:COG3829 6 LKELEEELEAILDSLDDGIIVVDADGRITYVNRAAERILGLPREEVIGKNVTELIPNSPLLEVLKTGKPVTGVIQK-TGG 84
|
90 100 110
....*....|....*....|....*....|....*
gi 503732216 174 QGIIVSLQLVPYGYNQKL----LISRDITRFEKIE 204
Cdd:COG3829 85 KGKTVIVTAIPIFEDGEVigavETFRDITELKRLE 119
|
|
| PRK13557 |
PRK13557 |
histidine kinase; Provisional |
214-427 |
7.77e-07 |
|
histidine kinase; Provisional
Pssm-ID: 237425 [Multi-domain] Cd Length: 540 Bit Score: 51.21 E-value: 7.77e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 214 VSHELRTPLTVISGFLETLSA---DENVNSGFNKRALVLMSEQTTRMQRLIEDLLILSRLENEQSivneKAVEVTSLLRG 290
Cdd:PRK13557 170 IAHDFNNLLQVMSGYLDVIQAalsHPDADRGRMARSVENIRAAAERAATLTQQLLAFARKQRLEG----RVLNLNGLVSG 245
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 291 ILQDAESLSAGrhQIKLNIASQDQLLGSE---EELRSAFGNLISNAIRYTPDSGEINI---NWEKRDGQGLFF------- 357
Cdd:PRK13557 246 MGELAERTLGD--AVTIETDLAPDLWNCRidpTQAEVALLNVLINARDAMPEGGRVTIrtrNVEIEDEDLAMYhglppgr 323
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 503732216 358 -----VQDSGIGIEPEHIPRLTERFYrvdssRSRETG-GTGLGLAIVKHVLSRHQARMEITSQVGKGSRFTIWFPA 427
Cdd:PRK13557 324 yvsiaVTDTGSGMPPEILARVMDPFF-----TTKEEGkGTGLGLSMVYGFAKQSGGAVRIYSEVGEGTTVRLYFPA 394
|
|
| PAS_8 |
pfam13188 |
PAS domain; PAS domains are involved in many signalling proteins where they are used as a ... |
99-153 |
2.47e-06 |
|
PAS domain; PAS domains are involved in many signalling proteins where they are used as a signal sensor domain. PAS domains appear in archaea, bacteria and eukaryotes. Several PAS-domain proteins are known to detect their signal by way of an associated cofactor. Heme, flavin, and a 4-hydroxycinnamyl chromophore are used in different proteins. This domain recognizes oxygen and CO (Matilla et al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 463802 [Multi-domain] Cd Length: 65 Bit Score: 44.85 E-value: 2.47e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 503732216 99 ERMRSVTSAMPDGIVILDETDRIEWCNPVAEQHLGINLsldTGQQITYLVRQIPF 153
Cdd:pfam13188 1 ERLRALFESSPDGILVLDEGGRIIYVNPAALELLGYEL---LGELLGELLDLLDP 52
|
|
| PAS |
smart00091 |
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ... |
99-148 |
3.52e-05 |
|
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels.
Pssm-ID: 214512 Cd Length: 67 Bit Score: 41.62 E-value: 3.52e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|
gi 503732216 99 ERMRSVTSAMPDGIVILDETDRIEWCNPVAEQHLGINLSLDTGQQITYLV 148
Cdd:smart00091 1 ERLRAILESLPDGIFVLDLDGRILYANPAAEELLGYSPEELIGKSLLELI 50
|
|
| ComP |
COG4585 |
Signal transduction histidine kinase ComP [Signal transduction mechanisms]; |
329-429 |
4.31e-04 |
|
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
Pssm-ID: 443642 [Multi-domain] Cd Length: 252 Bit Score: 41.91 E-value: 4.31e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 329 LISNAIRYTPDSgEININWEKRDGQGLFFVQDSGIGIEPEHIPrlterfyrvdssrsretgGTGLGLAIVKHVLSRHQAR 408
Cdd:COG4585 170 ALTNALKHAGAT-RVTVTLEVDDGELTLTVRDDGVGFDPEAAP------------------GGGLGLRGMRERAEALGGT 230
|
90 100
....*....|....*....|.
gi 503732216 409 MEITSQVGKGSRFTIWFPAKR 429
Cdd:COG4585 231 LTIGSAPGGGTRVRATLPLAA 251
|
|
| PAS |
COG2202 |
PAS domain [Signal transduction mechanisms]; |
89-204 |
1.01e-03 |
|
PAS domain [Signal transduction mechanisms];
Pssm-ID: 441804 [Multi-domain] Cd Length: 258 Bit Score: 40.78 E-value: 1.01e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 89 QSQELLSLALERMRSVTSAMPDGIVILDETDRIEWCNPVAEQHLGINLSLDTGQQITYLVRQIPFVEYLAA--------- 159
Cdd:COG2202 127 RAEEALRESEERLRLLVENAPDGIFVLDLDGRILYVNPAAEELLGYSPEELLGKSLLDLLHPEDRERLLELlrrlleggr 206
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 503732216 160 RKYSNPLILNQTRQQGIIVSLQLVPYGYNQK----LLISRDITRFEKIE 204
Cdd:COG2202 207 ESYELELRLKDGDGRWVWVEASAVPLRDGGEvigvLGIVRDITERKRAE 255
|
|
| HATPase_CheA-like |
cd16916 |
Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some ... |
320-426 |
2.07e-03 |
|
Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some hybrid sensor histidine kinases; This family includes the cytoplasmic histidine kinase (HK) CheA, a transmembrane receptor which, together with cytoplasmic adaptor protein (CheW), forms the lattice at the core of the chemosensory array that controls the cellular chemotaxis of motile bacteria and archaea. CheA forms a two-component signal transduction system (TCS) with the response regulator CheY. Proteins having this CheA-like HATPase domain generally also have a histidine-phosphotransfer domain, a histidine kinase homodimeric domain, and a regulatory domain; some are hybrid sensor histidine kinases as they contain a REC signal receiver domain.
Pssm-ID: 340393 [Multi-domain] Cd Length: 178 Bit Score: 39.10 E-value: 2.07e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 320 EELRSAFGNLISNAI------------RYTPDSGEININWEKRDGQGLFFVQDSGIGIEPEHIPR-LTERFYRVDSSRSR 386
Cdd:cd16916 37 EKLADPLTHLLRNAVdhgieapeerlaAGKPPEGTITLRAEHQGNQVVIEVSDDGRGIDREKIREkAIERGLITADEAAT 116
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 503732216 387 ----------------------ETGGTGLGLAIVKHVLSRHQARMEITSQVGKGSRFTIWFP 426
Cdd:cd16916 117 lsddevlnlifapgfstaeqvtDVSGRGVGMDVVKRSIESLGGTIEVESEPGQGTTFTIRLP 178
|
|
| HATPase_YpdA-YehU-LytS-like |
cd16924 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
329-426 |
2.20e-03 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YpdA, YehU, Bacillus subtilis LytS, and some hybrid sensor histidine kinases; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. It also includes the HATPase domains of Escherichia coli YpdA and YehU, HKs of YpdA-YpdB and YehU-YehTCSs, which are involved together in a nutrient sensing regulatory network. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), some having accessory sensor domain(s) such as Cache, HAMP or GAF; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340401 [Multi-domain] Cd Length: 103 Bit Score: 37.43 E-value: 2.20e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 329 LISNAIRY----TPDSGEININWEKRDGQGLFFVQDSGIGIEPEHIPRLTErfyrvdssrsRETGGTGLGLAIVKHVLSR 404
Cdd:cd16924 9 LVENAIQHglspLTDKGVVTISALKEDNHVMIEVEDNGRGIDPKVLNILGK----------KPKEGNGIGLYNVHQRLIL 78
|
90 100
....*....|....*....|....*
gi 503732216 405 ---HQARMEITSQVGKGSRFTIWFP 426
Cdd:cd16924 79 lfgEDYGIHIASEPDKGTRITFTIP 103
|
|
| HATPase_c_2 |
pfam13581 |
Histidine kinase-like ATPase domain; |
294-400 |
6.17e-03 |
|
Histidine kinase-like ATPase domain;
Pssm-ID: 433327 [Multi-domain] Cd Length: 127 Bit Score: 36.88 E-value: 6.17e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503732216 294 DAESLSAGRHQIKlNIASQDQLLGSE-EELRSAFGNLISNAIRY---TPDSGEININWEKRDGQGLFFVQDSGIGIEPEH 369
Cdd:pfam13581 4 DPEQLRAARRVLE-AVLRRAGLPEELlDEVELAVGEACTNAVEHayrEGPEGPVEVRLTSDGGGLVVTVADSGPPFDPLT 82
|
90 100 110
....*....|....*....|....*....|.
gi 503732216 370 IPRLTErfyrVDSSRSRETGgtGLGLAIVKH 400
Cdd:pfam13581 83 LPPPDL----EEPDEDRKEG--GRGLALIRG 107
|
|
| |
