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Conserved domains on  [gi|503802029|ref|WP_014036023|]
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MULTISPECIES: HAMP domain-containing sensor histidine kinase [Stenotrophomonas]

Protein Classification

sensor histidine kinase( domain architecture ID 11428264)

sensor histidine kinase is part of a two-component regulatory system and functions as a protein kinase that phosphorylates a target protein in response to a signal

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
105-422 1.85e-59

Signal transduction histidine kinase [Signal transduction mechanisms];


:

Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 196.67  E-value: 1.85e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 105 LVDVRPAGRLYLVFLRSRAEMLAFWFGIVPVLLTLLAVYGASWVTYRASKRLVSPVNWLARRVSRWDPGHPEAADLEPNK 184
Cdd:COG0642    1 LLLLLLLLVLLLLLLLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 185 LPADMQGETRQLAAALHSLANRVSAHVARERNFTRDASHELRTPLTVIRVASDMALgdETLQPRLRRSLQRIQRAGRDME 264
Cdd:COG0642   81 LLLLLLLLLLLLLLLLLALLLLLEEANEAKSRFLANVSHELRTPLTAIRGYLELLL--EELDEEQREYLETILRSADRLL 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 265 AVIDAFLILAR--EADVEPQIELFDVNDIVRYEVDNANELLGNRPVSVHLH-SEGPVQLHAPPRVLQVVVSNLVRNACSY 341
Cdd:COG0642  159 RLINDLLDLSRleAGKLELEPEPVDLAELLEEVVELFRPLAEEKGIELELDlPDDLPTVRGDPDRLRQVLLNLLSNAIKY 238
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 342 TDEG---RIDVQVLNDRVV--VRDTGIGMSAEALSRAFEPFYRAEPSRP-QGTGLGLSIVRRLCDRFGWKVSLASEPGKG 415
Cdd:COG0642  239 TPEGgtvTVSVRREGDRVRisVEDTGPGIPPEDLERIFEPFFRTDPSRRgGGTGLGLAIVKRIVELHGGTIEVESEPGKG 318

                 ....*..
gi 503802029 416 TEATVIF 422
Cdd:COG0642  319 TTFTVTL 325
 
Name Accession Description Interval E-value
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
105-422 1.85e-59

Signal transduction histidine kinase [Signal transduction mechanisms];


Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 196.67  E-value: 1.85e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 105 LVDVRPAGRLYLVFLRSRAEMLAFWFGIVPVLLTLLAVYGASWVTYRASKRLVSPVNWLARRVSRWDPGHPEAADLEPNK 184
Cdd:COG0642    1 LLLLLLLLVLLLLLLLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 185 LPADMQGETRQLAAALHSLANRVSAHVARERNFTRDASHELRTPLTVIRVASDMALgdETLQPRLRRSLQRIQRAGRDME 264
Cdd:COG0642   81 LLLLLLLLLLLLLLLLLALLLLLEEANEAKSRFLANVSHELRTPLTAIRGYLELLL--EELDEEQREYLETILRSADRLL 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 265 AVIDAFLILAR--EADVEPQIELFDVNDIVRYEVDNANELLGNRPVSVHLH-SEGPVQLHAPPRVLQVVVSNLVRNACSY 341
Cdd:COG0642  159 RLINDLLDLSRleAGKLELEPEPVDLAELLEEVVELFRPLAEEKGIELELDlPDDLPTVRGDPDRLRQVLLNLLSNAIKY 238
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 342 TDEG---RIDVQVLNDRVV--VRDTGIGMSAEALSRAFEPFYRAEPSRP-QGTGLGLSIVRRLCDRFGWKVSLASEPGKG 415
Cdd:COG0642  239 TPEGgtvTVSVRREGDRVRisVEDTGPGIPPEDLERIFEPFFRTDPSRRgGGTGLGLAIVKRIVELHGGTIEVESEPGKG 318

                 ....*..
gi 503802029 416 TEATVIF 422
Cdd:COG0642  319 TTFTVTL 325
phoR_proteo TIGR02966
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory ...
215-422 2.74e-40

phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory histidine kinase PhoR associated with the phosphate ABC transporter in most Proteobacteria. Related proteins from Gram-positive organisms are not included in this model. The phoR gene usually is adjacent to the response regulator phoB gene (TIGR02154). [Signal transduction, Two-component systems]


Pssm-ID: 274368 [Multi-domain]  Cd Length: 333  Bit Score: 146.20  E-value: 2.74e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029  215 RNFTRDASHELRTPLTVIR-VASDMALGDETLQPRLRRSLQRIQRAGRDMEAVIDAFLILAR--EADVEPQIELFDVNDI 291
Cdd:TIGR02966 115 RDFVANVSHELRTPLTVLRgYLETLADGPDEDPEEWNRALEIMLEQSQRMQSLVEDLLTLSRleSAASPLEDEPVDMPAL 194
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029  292 VRYEVDNANELLGNRPVSVHLHSEGPVQLHAPPRVLQVVVSNLVRNACSYT-DEGRIDVQVLND----RVVVRDTGIGMS 366
Cdd:TIGR02966 195 LDHLRDEAEALSQGKNHQITFEIDGGVDVLGDEDELRSAFSNLVSNAIKYTpEGGTITVRWRRDgggaEFSVTDTGIGIA 274
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 503802029  367 AEALSRAFEPFYRAEPSRPQ---GTGLGLSIVRRLCDRFGWKVSLASEPGKGTEATVIF 422
Cdd:TIGR02966 275 PEHLPRLTERFYRVDKSRSRdtgGTGLGLAIVKHVLSRHHARLEIESELGKGSTFSFIF 333
PRK10337 PRK10337
sensor protein QseC; Provisional
129-420 2.63e-33

sensor protein QseC; Provisional


Pssm-ID: 182388 [Multi-domain]  Cd Length: 449  Bit Score: 129.77  E-value: 2.63e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 129 WFGIVPVLLTLLAVygaswvtyrASKRLVSPVNWLARRVSRWDPghPEAADLEPNKLPAdmqgETRQLAAALHSLANRVS 208
Cdd:PRK10337 167 WLVALPIMLIILMV---------LLGRELAPLKKLALALRMRDP--DSETPLNATGVPS----EVRPLVEALNQLFARTH 231
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 209 AHVARERNFTRDASHELRTPLTVIRVASDMA-LGDETLQPRlRRSLQR----IQRAGRdmeaVIDAFLILAR---EADVE 280
Cdd:PRK10337 232 AMMVRERRFTSDAAHELRSPLAALKVQTEVAqLSDDDPQAR-KKALLQlhagIDRATR----LVDQLLTLSRldsLDNLQ 306
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 281 pQIELFDVNDIVRYEVDNANELLGNRPVSVHLHSEG-PVQLHAPPRVLQVVVSNLVRNACSYTDEG-RIDVQVLNDRVVV 358
Cdd:PRK10337 307 -DVAEIPLEDLLQSAVMDIYHTAQQAGIDVRLTLNAhPVIRTGQPLLLSLLVRNLLDNAIRYSPQGsVVDVTLNARNFTV 385
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 503802029 359 RDTGIGMSAEALSRAFEPFYRAEPSRPQGTGLGLSIVRRLCDRFGWKVSLASEPGKGTEATV 420
Cdd:PRK10337 386 RDNGPGVTPEALARIGERFYRPPGQEATGSGLGLSIVRRIAKLHGMNVSFGNAPEGGFEAKV 447
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
324-423 3.88e-29

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 109.66  E-value: 3.88e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029   324 PRVLQVVVSNLVRNACSYTDE-GRIDVQVLND----RVVVRDTGIGMSAEALSRAFEPFYRAEPSRPQ--GTGLGLSIVR 396
Cdd:smart00387   3 PDRLRQVLSNLLDNAIKYTPEgGRITVTLERDgdhvEITVEDNGPGIPPEDLEKIFEPFFRTDKRSRKigGTGLGLSIVK 82
                           90       100
                   ....*....|....*....|....*..
gi 503802029   397 RLCDRFGWKVSLASEPGKGTEATVIFR 423
Cdd:smart00387  83 KLVELHGGEISVESEPGGGTTFTITLP 109
MtrAB_MtrB NF040691
MtrAB system histidine kinase MtrB;
114-417 9.79e-29

MtrAB system histidine kinase MtrB;


Pssm-ID: 468655 [Multi-domain]  Cd Length: 507  Bit Score: 117.82  E-value: 9.79e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 114 LYLVF-LRSRAEMLAF---WFGIVPVLLTLLAVYGASWVTyrasKRLVSPVNWLARRVSRWDPGHPEAadlepnKLPADM 189
Cdd:NF040691 170 LYLLFpLEDEQSTLALvrgTLLLGGLALVVLLGLIAWLVT----RQVVAPVRSAARTAERFAAGDLSE------RMPVKG 239
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 190 QGETRQLAAALHSLANRVSAHVAR-------ERNFTRDASHELRTPLTVIRVASD-MALGDETLQPRLRRSLQRIQRAGR 261
Cdd:NF040691 240 EDDLARLARSFNQMADSLQRQIRQleelsrlQQRFVSDVSHELRTPLTTIRMAADvIHDSRDDFDPATARSAELLHTELD 319
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 262 DMEAVIDAFLILAR--EADVEPQIELFDVNDIVRYEVDNANELLGNRPVSVHLHS-EGPVQLHAPPRVLQVVVSNLVRNA 338
Cdd:NF040691 320 RFESLLSDLLEISRfdAGAAELDVEPVDLRPLVRRVVDALRQLAERAGVELRVDApGTPVVAEVDPRRVERVLRNLVVNA 399
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 339 CSYTDEGRIDVQVLNDR----VVVRDTGIGMSAEALSRAFEPFYRAEPSRPQ---GTGLGLSIVR---RLcdRFGWkVSL 408
Cdd:NF040691 400 IEHGEGKPVVVTVAQDDtavaVTVRDHGVGLKPGEVALVFDRFWRADPARARttgGTGLGLAIALedaRL--HGGW-LEA 476

                 ....*....
gi 503802029 409 ASEPGKGTE 417
Cdd:NF040691 477 WGRPGQGSQ 485
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
324-423 2.71e-26

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 102.06  E-value: 2.71e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029  324 PRVLQVVVSNLVRNACSYT-DEGRIDVQVLND---RVVVRDTGIGMSAEALSRAFEPFYRAEPSRPQGTGLGLSIVRRLC 399
Cdd:pfam02518   3 ELRLRQVLSNLLDNALKHAaKAGEITVTLSEGgelTLTVEDNGIGIPPEDLPRIFEPFSTADKRGGGGTGLGLSIVRKLV 82
                          90       100
                  ....*....|....*....|....
gi 503802029  400 DRFGWKVSLASEPGKGTEATVIFR 423
Cdd:pfam02518  83 ELLGGTITVESEPGGGTTVTLTLP 106
HATPase_EvgS-ArcB-TorS-like cd16922
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ...
327-421 1.21e-25

Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340399 [Multi-domain]  Cd Length: 110  Bit Score: 100.26  E-value: 1.21e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 327 LQVVVSNLVRNACSYTDEGRID--VQVLND-------RVVVRDTGIGMSAEALSRAFEPFYRAEPS---RPQGTGLGLSI 394
Cdd:cd16922    1 LRQILLNLLGNAIKFTEEGEVTlrVSLEEEeedgvqlRFSVEDTGIGIPEEQQARLFEPFSQADSSttrKYGGTGLGLAI 80
                         90       100
                 ....*....|....*....|....*..
gi 503802029 395 VRRLCDRFGWKVSLASEPGKGTEATVI 421
Cdd:cd16922   81 SKKLVELMGGDISVESEPGQGSTFTFT 107
BaeS_SmeS NF012163
sensor histidine kinase efflux regulator BaeS;
129-422 1.59e-20

sensor histidine kinase efflux regulator BaeS;


Pssm-ID: 411086 [Multi-domain]  Cd Length: 457  Bit Score: 93.35  E-value: 1.59e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 129 WFGIVpVLLTLLAVYgASWVTYRA----SKRLVSPVNWLAR-----RVSRwdpghpeAADLEPNKLPADMQgetrQLAAA 199
Cdd:NF012163 166 SWLIV-ALALLLAAL-AAFLLARGllapVKRLVEATHRLAAgdyttRVTP-------TSNDELGKLAQDFN----QLAST 232
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 200 LHSlanrvsaHVARERNFTRDASHELRTPLTVIRvASDMALGDeTLQPRLRRSLQRIQRAGRDMEAVID--AFLILAREA 277
Cdd:NF012163 233 LEK-------NEQMRRDFMADISHELRTPLAVLR-AELEAIQD-GIRKFTPESLDSLQAEVGTLTKLVDdlHDLSMSDEG 303
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 278 DVEPQIELFDVNDIVRYEVDNANELLGNRPVSVHLHSEGPVQLHAPPRVLQVVVSNLVRNACSYTDE-GRIDVQVLND-- 354
Cdd:NF012163 304 ALAYQKASVDLVPLLEVEGGAFRERFASAGLELEVSLPDSSLVFGDRDRLMQLFNNLLENSLRYTDSgGSLHISASQRpk 383
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 503802029 355 --RVVVRDTGIGMSAEALSRAFEPFYRAEPSR---PQGTGLGLSIVRRLCDRFGWKVSLASEPGKGTEATVIF 422
Cdd:NF012163 384 evTLTVADSAPGVSDEQLARLFERFYRVEVSRnraSGGSGLGLAISLNIVQAHGGTLHAAHSPLGGLRIVVTL 456
HK_WalK NF033092
cell wall metabolism sensor histidine kinase WalK; This model describes WalK as found in ...
215-422 5.31e-20

cell wall metabolism sensor histidine kinase WalK; This model describes WalK as found in Staphylococcus aureus (sp|Q2G2U4.1|WALK_STAA8). A shorter version, as found in Streptococcus pneumoniae, called WalK(Spn) or VicK, is not included. WalK is part of a two-component system and works with partner protein WalR.


Pssm-ID: 467964 [Multi-domain]  Cd Length: 594  Bit Score: 92.12  E-value: 5.31e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 215 RNFTRDASHELRTPLTVIR----VASDMALGDETLQPRLrrsLQRIQRAGRDMEAVIDAFLILAR--EADVEPQIELFDV 288
Cdd:NF033092 373 REFVANVSHELRTPLTTMRsyleALADGAWKDPELAPRF---LGVTQNETERMIRLVNDLLQLSRmdSKDYKLNKEWVNF 449
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 289 ND-----IVRYEVDNANE------LLGNRPVSVHLHsegpvqlhaPPRVLQvVVSNLVRNACSYT-DEGRIDVQVL--ND 354
Cdd:NF033092 450 NEffnyiIDRFEMILKNKnitfkrEFPKRDLWVEID---------TDKITQ-VLDNIISNAIKYSpEGGTITFRLLetHN 519
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 503802029 355 RVVVR--DTGIGMSAEALSRAFEPFYRAEP--SRPQ-GTGLGLSIVRRLCDRFGWKVSLASEPGKGTeaTVIF 422
Cdd:NF033092 520 RIIISisDQGLGIPKKDLDKIFDRFYRVDKarSRKMgGTGLGLAIAKEVVEAHGGRIWAESEEGKGT--TIYF 590
ActS_PrrB_HisK NF033792
ActS/PrrB/RegB family redox-sensitive histidine kinase; This redox-responsive histidine kinase, ...
221-421 1.34e-08

ActS/PrrB/RegB family redox-sensitive histidine kinase; This redox-responsive histidine kinase, found in alpha-proteobacteria, shows strong sequence conservation, including the notable motif [VA]AAAAHELGTPxTI. It always acts as a partner to an ActR/PrrA/RegA family global response regulator transcription factor in a two-component sensory transduction system. Lineage-specific names and gene symbols given to this histidine kinase reflect downstream regulator changes such as entry into stationary phase, anaerobic expression of photosynthesis genes, and survival of exposure to low pH.


Pssm-ID: 468186 [Multi-domain]  Cd Length: 423  Bit Score: 56.37  E-value: 1.34e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 221 ASHELRTPLTVIR-VASDMA--LGD-----ETLQ------PRLRRSLQRIQRAGRDMEAVID--AFLILAREAdVEPQIE 284
Cdd:NF033792 209 AAHELGTPLATIAlVAKELEreLPDdpplrEDAEllrsqaERCRDILRRLTSLGEEGDAHLDrlPLSALIEEA-AAPHRG 287
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 285 lFDVNDIVRYEVDNANELLGNRPVSVhlhsegpvqLHApprvlqvvVSNLVRNACSY-TDEGRIDVQVLNDRV--VVRDT 361
Cdd:NF033792 288 -FGKEIEVVVAGDPGEEPVIRRNPEI---------LYG--------LGNLIENAVDFaRSTVTVTASWDAESVtiTIEDD 349
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 503802029 362 GIGMSAEALSRAFEPFY---RAEPSRP--QGTGLGLSIVRRLCDRFGWKVSLA--SEPGKGTEATVI 421
Cdd:NF033792 350 GPGFPPDVLSRIGEPYVttrRGEERRPggGGLGLGLFIAKTLLERSGATVTFAnrPPPEGGAVVTVR 416
 
Name Accession Description Interval E-value
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
105-422 1.85e-59

Signal transduction histidine kinase [Signal transduction mechanisms];


Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 196.67  E-value: 1.85e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 105 LVDVRPAGRLYLVFLRSRAEMLAFWFGIVPVLLTLLAVYGASWVTYRASKRLVSPVNWLARRVSRWDPGHPEAADLEPNK 184
Cdd:COG0642    1 LLLLLLLLVLLLLLLLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 185 LPADMQGETRQLAAALHSLANRVSAHVARERNFTRDASHELRTPLTVIRVASDMALgdETLQPRLRRSLQRIQRAGRDME 264
Cdd:COG0642   81 LLLLLLLLLLLLLLLLLALLLLLEEANEAKSRFLANVSHELRTPLTAIRGYLELLL--EELDEEQREYLETILRSADRLL 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 265 AVIDAFLILAR--EADVEPQIELFDVNDIVRYEVDNANELLGNRPVSVHLH-SEGPVQLHAPPRVLQVVVSNLVRNACSY 341
Cdd:COG0642  159 RLINDLLDLSRleAGKLELEPEPVDLAELLEEVVELFRPLAEEKGIELELDlPDDLPTVRGDPDRLRQVLLNLLSNAIKY 238
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 342 TDEG---RIDVQVLNDRVV--VRDTGIGMSAEALSRAFEPFYRAEPSRP-QGTGLGLSIVRRLCDRFGWKVSLASEPGKG 415
Cdd:COG0642  239 TPEGgtvTVSVRREGDRVRisVEDTGPGIPPEDLERIFEPFFRTDPSRRgGGTGLGLAIVKRIVELHGGTIEVESEPGKG 318

                 ....*..
gi 503802029 416 TEATVIF 422
Cdd:COG0642  319 TTFTVTL 325
WalK COG5002
Sensor histidine kinase WalK [Signal transduction mechanisms];
100-422 3.41e-54

Sensor histidine kinase WalK [Signal transduction mechanisms];


Pssm-ID: 444026 [Multi-domain]  Cd Length: 390  Bit Score: 184.76  E-value: 3.41e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 100 DDQLVLVDVRPAGRLYLVFLRSRAEMLAFWFGIVPVLLTLLAVYGASWVTYRASKRLVSPVNWLARRVSRWDPGHPEAAD 179
Cdd:COG5002   51 LLALLLLLLLLLLLLLALLLLLLLLLLLLALALLLLALLLLLLLLLLLLALLILLLLLALLILLAALLLLLSELLLLLLL 130
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 180 LEPNKLPADMQGETRQLAAALHSLANRVSAHVARERNFTRDASHELRTPLTVIRVASDMAL-GDETLQPRLRRSLQRIQR 258
Cdd:COG5002  131 LGRLSLRLSALLLGLLLLAAVERDITELERLEQMRREFVANVSHELRTPLTSIRGYLELLLdGAADDPEERREYLEIILE 210
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 259 AGRDMEAVIDAFLILAR--EADVEPQIELFDVNDIVRYEVDNANELLGNRPVSVHLH-SEGPVQLHAPPRVLQVVVSNLV 335
Cdd:COG5002  211 EAERLSRLVNDLLDLSRleSGELKLEKEPVDLAELLEEVVEELRPLAEEKGIELELDlPEDPLLVLGDPDRLEQVLTNLL 290
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 336 RNACSYTDEG---RIDVQVLNDRVV--VRDTGIGMSAEALSRAFEPFYRAEPSR---PQGTGLGLSIVRRLCDRFGWKVS 407
Cdd:COG5002  291 DNAIKYTPEGgtiTVSLREEDDQVRisVRDTGIGIPEEDLPRIFERFYRVDKSRsreTGGTGLGLAIVKHIVEAHGGRIW 370
                        330
                 ....*....|....*
gi 503802029 408 LASEPGKGTEATVIF 422
Cdd:COG5002  371 VESEPGKGTTFTITL 385
KdpD COG2205
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
215-422 1.36e-53

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];


Pssm-ID: 441807 [Multi-domain]  Cd Length: 239  Bit Score: 178.56  E-value: 1.36e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 215 RNFTRDASHELRTPLTVIRVASDMALGDETLQP-RLRRSLQRIQRAGRDMEAVIDAFLILAR--EADVEPQIELFDVNDI 291
Cdd:COG2205   17 SEFLANVSHELRTPLTSILGAAELLLDEEDLSPeERRELLEIIRESAERLLRLIEDLLDLSRleSGKLSLELEPVDLAEL 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 292 VRYEVDNANELLGNRPVSVHLH-SEGPVQLHAPPRVLQVVVSNLVRNACSYTDEG---RIDVQVLNDRVV--VRDTGIGM 365
Cdd:COG2205   97 LEEAVEELRPLAEEKGIRLELDlPPELPLVYADPELLEQVLANLLDNAIKYSPPGgtiTISARREGDGVRisVSDNGPGI 176
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 503802029 366 SAEALSRAFEPFYRAEPSR-PQGTGLGLSIVRRLCDRFGWKVSLASEPGKGTEATVIF 422
Cdd:COG2205  177 PEEELERIFERFYRGDNSRgEGGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTL 234
phoR_proteo TIGR02966
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory ...
215-422 2.74e-40

phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory histidine kinase PhoR associated with the phosphate ABC transporter in most Proteobacteria. Related proteins from Gram-positive organisms are not included in this model. The phoR gene usually is adjacent to the response regulator phoB gene (TIGR02154). [Signal transduction, Two-component systems]


Pssm-ID: 274368 [Multi-domain]  Cd Length: 333  Bit Score: 146.20  E-value: 2.74e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029  215 RNFTRDASHELRTPLTVIR-VASDMALGDETLQPRLRRSLQRIQRAGRDMEAVIDAFLILAR--EADVEPQIELFDVNDI 291
Cdd:TIGR02966 115 RDFVANVSHELRTPLTVLRgYLETLADGPDEDPEEWNRALEIMLEQSQRMQSLVEDLLTLSRleSAASPLEDEPVDMPAL 194
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029  292 VRYEVDNANELLGNRPVSVHLHSEGPVQLHAPPRVLQVVVSNLVRNACSYT-DEGRIDVQVLND----RVVVRDTGIGMS 366
Cdd:TIGR02966 195 LDHLRDEAEALSQGKNHQITFEIDGGVDVLGDEDELRSAFSNLVSNAIKYTpEGGTITVRWRRDgggaEFSVTDTGIGIA 274
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 503802029  367 AEALSRAFEPFYRAEPSRPQ---GTGLGLSIVRRLCDRFGWKVSLASEPGKGTEATVIF 422
Cdd:TIGR02966 275 PEHLPRLTERFYRVDKSRSRdtgGTGLGLAIVKHVLSRHHARLEIESELGKGSTFSFIF 333
NtrY COG5000
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ...
222-422 1.41e-36

Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];


Pssm-ID: 444024 [Multi-domain]  Cd Length: 422  Bit Score: 138.56  E-value: 1.41e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 222 SHELRTPLTVI-----RVASDMALGDETLQPRLRRSLQRIQRAGRDMEAVIDAFLILAREAdvEPQIELFDVNDIVRYEV 296
Cdd:COG5000  209 AHEIKNPLTPIqlsaeRLRRKLADKLEEDREDLERALDTIIRQVDRLKRIVDEFLDFARLP--EPQLEPVDLNELLREVL 286
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 297 DNANELLGNRPVSVHLH-SEGPVQLHAPPRVLQVVVSNLVRNAC-SYTDEGRIDVQV--LNDRVV--VRDTGIGMSAEAL 370
Cdd:COG5000  287 ALYEPALKEKDIRLELDlDPDLPEVLADRDQLEQVLINLLKNAIeAIEEGGEIEVSTrrEDGRVRieVSDNGPGIPEEVL 366
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 503802029 371 SRAFEPFYRaepSRPQGTGLGLSIVRRLCDRFGWKVSLASEPGKGTEATVIF 422
Cdd:COG5000  367 ERIFEPFFT---TKPKGTGLGLAIVKKIVEEHGGTIELESRPGGGTTFTIRL 415
COG4191 COG4191
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ...
223-422 4.06e-35

Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];


Pssm-ID: 443345 [Multi-domain]  Cd Length: 361  Bit Score: 133.00  E-value: 4.06e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 223 HELRTPLTVIRVASDMA---LGDETLQPRLRRSLQRIQRAGRDMEAVIDAFLILAREAdvEPQIELFDVNDIVRYEVDNA 299
Cdd:COG4191  151 HEINNPLAAILGNAELLrrrLEDEPDPEELREALERILEGAERAAEIVRSLRAFSRRD--EEEREPVDLNELIDEALELL 228
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 300 NELLGNRPVSVHLH-SEGPVQLHAPPRVLQVVVSNLVRNAC---SYTDEGRIDVQVLND----RVVVRDTGIGMSAEALS 371
Cdd:COG4191  229 RPRLKARGIEVELDlPPDLPPVLGDPGQLEQVLLNLLINAIdamEEGEGGRITISTRREgdyvVISVRDNGPGIPPEVLE 308
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 503802029 372 RAFEPFY--RAEPsrpQGTGLGLSIVRRLCDRFGWKVSLASEPGKGTEATVIF 422
Cdd:COG4191  309 RIFEPFFttKPVG---KGTGLGLSISYGIVEKHGGRIEVESEPGGGTTFTITL 358
COG4251 COG4251
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ...
5-422 5.61e-34

Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];


Pssm-ID: 443393 [Multi-domain]  Cd Length: 503  Bit Score: 132.60  E-value: 5.61e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029   5 LPRKIRIAFILQAVLASLGILLGAWLVSLVIKHSLVGAALREEAAYYWTLHEASPVQPPPNTQNIRGYLLESGQSALSLP 84
Cdd:COG4251   84 LLLLELALVLLALLLVLLLLLALLLLLALLLLLELLLLLLALLLLLLLLALLLLEELALLRLALALLLLLLLLLLLLLLL 163
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029  85 ANLRNLEPGFHELPKDDQLVLVDVRPAGRLYLVFLRSRAEMLAFWFGIVPVLLTLLAVYGASWVTYRASKRLVSPVNWLA 164
Cdd:COG4251  164 LALILALLLAALAELELLLLLLLVLLLLLLLLLLLLLLLLRLLLELLLLLEAELLLSLGGGLGLLLLLLLLLVLLLLLIL 243
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 165 RRVSRWDPGHPEAADLEPNKLPADMQGETRQLAAALHSLanrvsahvareRNFTRDASHELRTPLTVIRVASDMALGD-- 242
Cdd:COG4251  244 LLLLLILVLELLELRLELEELEEELEERTAELERSNEEL-----------EQFAYVASHDLREPLRKISGFSQLLEEDyg 312
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 243 ETLQPRLRRSLQRIQRAGRDMEAVIDAFLILAREADVEPQIELFDVNDIVRYEVDNANELLGNRPVSVHlHSEGPVqLHA 322
Cdd:COG4251  313 DKLDEEGREYLERIRDAAERMQALIDDLLAYSRVGRQELEFEPVDLNELLEEVLEDLEPRIEERGAEIE-VGPLPT-VRG 390
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 323 PPRVLQVVVSNLVRNACSYTDEG-----RIDVQVLNDRVV--VRDTGIGMSAEALSRAFEPFYRAEP-SRPQGTGLGLSI 394
Cdd:COG4251  391 DPTLLRQVFQNLISNAIKYSRPGeppriEIGAEREGGEWVfsVRDNGIGIDPEYAEKIFEIFQRLHSrDEYEGTGIGLAI 470
                        410       420
                 ....*....|....*....|....*...
gi 503802029 395 VRRLCDRFGWKVSLASEPGKGteATVIF 422
Cdd:COG4251  471 VKKIVERHGGRIWVESEPGEG--ATFYF 496
PRK10337 PRK10337
sensor protein QseC; Provisional
129-420 2.63e-33

sensor protein QseC; Provisional


Pssm-ID: 182388 [Multi-domain]  Cd Length: 449  Bit Score: 129.77  E-value: 2.63e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 129 WFGIVPVLLTLLAVygaswvtyrASKRLVSPVNWLARRVSRWDPghPEAADLEPNKLPAdmqgETRQLAAALHSLANRVS 208
Cdd:PRK10337 167 WLVALPIMLIILMV---------LLGRELAPLKKLALALRMRDP--DSETPLNATGVPS----EVRPLVEALNQLFARTH 231
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 209 AHVARERNFTRDASHELRTPLTVIRVASDMA-LGDETLQPRlRRSLQR----IQRAGRdmeaVIDAFLILAR---EADVE 280
Cdd:PRK10337 232 AMMVRERRFTSDAAHELRSPLAALKVQTEVAqLSDDDPQAR-KKALLQlhagIDRATR----LVDQLLTLSRldsLDNLQ 306
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 281 pQIELFDVNDIVRYEVDNANELLGNRPVSVHLHSEG-PVQLHAPPRVLQVVVSNLVRNACSYTDEG-RIDVQVLNDRVVV 358
Cdd:PRK10337 307 -DVAEIPLEDLLQSAVMDIYHTAQQAGIDVRLTLNAhPVIRTGQPLLLSLLVRNLLDNAIRYSPQGsVVDVTLNARNFTV 385
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 503802029 359 RDTGIGMSAEALSRAFEPFYRAEPSRPQGTGLGLSIVRRLCDRFGWKVSLASEPGKGTEATV 420
Cdd:PRK10337 386 RDNGPGVTPEALARIGERFYRPPGQEATGSGLGLSIVRRIAKLHGMNVSFGNAPEGGFEAKV 447
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
324-423 3.88e-29

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 109.66  E-value: 3.88e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029   324 PRVLQVVVSNLVRNACSYTDE-GRIDVQVLND----RVVVRDTGIGMSAEALSRAFEPFYRAEPSRPQ--GTGLGLSIVR 396
Cdd:smart00387   3 PDRLRQVLSNLLDNAIKYTPEgGRITVTLERDgdhvEITVEDNGPGIPPEDLEKIFEPFFRTDKRSRKigGTGLGLSIVK 82
                           90       100
                   ....*....|....*....|....*..
gi 503802029   397 RLCDRFGWKVSLASEPGKGTEATVIFR 423
Cdd:smart00387  83 KLVELHGGEISVESEPGGGTTFTITLP 109
MtrAB_MtrB NF040691
MtrAB system histidine kinase MtrB;
114-417 9.79e-29

MtrAB system histidine kinase MtrB;


Pssm-ID: 468655 [Multi-domain]  Cd Length: 507  Bit Score: 117.82  E-value: 9.79e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 114 LYLVF-LRSRAEMLAF---WFGIVPVLLTLLAVYGASWVTyrasKRLVSPVNWLARRVSRWDPGHPEAadlepnKLPADM 189
Cdd:NF040691 170 LYLLFpLEDEQSTLALvrgTLLLGGLALVVLLGLIAWLVT----RQVVAPVRSAARTAERFAAGDLSE------RMPVKG 239
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 190 QGETRQLAAALHSLANRVSAHVAR-------ERNFTRDASHELRTPLTVIRVASD-MALGDETLQPRLRRSLQRIQRAGR 261
Cdd:NF040691 240 EDDLARLARSFNQMADSLQRQIRQleelsrlQQRFVSDVSHELRTPLTTIRMAADvIHDSRDDFDPATARSAELLHTELD 319
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 262 DMEAVIDAFLILAR--EADVEPQIELFDVNDIVRYEVDNANELLGNRPVSVHLHS-EGPVQLHAPPRVLQVVVSNLVRNA 338
Cdd:NF040691 320 RFESLLSDLLEISRfdAGAAELDVEPVDLRPLVRRVVDALRQLAERAGVELRVDApGTPVVAEVDPRRVERVLRNLVVNA 399
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 339 CSYTDEGRIDVQVLNDR----VVVRDTGIGMSAEALSRAFEPFYRAEPSRPQ---GTGLGLSIVR---RLcdRFGWkVSL 408
Cdd:NF040691 400 IEHGEGKPVVVTVAQDDtavaVTVRDHGVGLKPGEVALVFDRFWRADPARARttgGTGLGLAIALedaRL--HGGW-LEA 476

                 ....*....
gi 503802029 409 ASEPGKGTE 417
Cdd:NF040691 477 WGRPGQGSQ 485
KinB COG5806
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome ...
222-422 7.17e-27

Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444508 [Multi-domain]  Cd Length: 412  Bit Score: 111.11  E-value: 7.17e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 222 SHELRTPLTVIRVASDMALGDETLQPRLRR----SLQRIQRAgrdmEAVIDAFLILAREAdvEPQIELFDVNDIVRYEVD 297
Cdd:COG5806  209 AHEVRNPLTVVRGFIQLLQEPELSDEKRKQyiriALEELDRA----EAIITDYLTFAKPQ--PEKLEKIDVSEELEHVID 282
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 298 NANELLGNRPVSVHLHSEGPVQLHAPPRVLQVVVSNLVRNAC-SYTDEGRIDVQVLNDR----VVVRDTGIGMSAEALSR 372
Cdd:COG5806  283 VLSPYANMNNVEIQTELEPGLYIEGDRQKLQQCLINIIKNGIeAMPNGGTLTIDVSIDKnkviISIKDTGVGMTKEQLER 362
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 503802029 373 AFEPFYRaepSRPQGTGLGLSIVRRLCDRFGWKVSLASEPGKGTEATVIF 422
Cdd:COG5806  363 LGEPYFS---TKEKGTGLGTMVSYRIIEAMNGTIRVESEVGKGTTFTITL 409
cztS_silS_copS TIGR01386
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ...
135-414 1.62e-26

heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.


Pssm-ID: 273593 [Multi-domain]  Cd Length: 457  Bit Score: 110.94  E-value: 1.62e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029  135 VLLTLLAVYGASWVTYRASKRLVSPVNWLARRVSRWDPgHPEAADLEPNKLPAdmqgETRQLAAALHSLANRVSAHVARE 214
Cdd:TIGR01386 167 ILIAVLLVLLTALLGWWITRLGLEPLRRLSAVAARISP-ESLDQRLDPSRAPA----ELRELAQSFNAMLGRLEDAFQRL 241
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029  215 RNFTRDASHELRTPLTVIRVASDMALGDETLQPRLRRSLQRIQRAGRDMEAVIDAFLILAR--EADVEPQIELFDVNDIV 292
Cdd:TIGR01386 242 SQFSADLAHELRTPLTNLLGQTQVALSQPRTGEEYREVLESNLEELERLSRMVSDMLFLARadNGQLALERVRLDLAAEL 321
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029  293 RYEVDNANELLGNRPVSVHLhsEGPVQLHAPPRVLQVVVSNLVRNACSYT-DEGRIDVQVLND----RVVVRDTGIGMSA 367
Cdd:TIGR01386 322 AKVAEYFEPLAEERGVRIRV--EGEGLVRGDPQMFRRAISNLLSNALRHTpDGGTITVRIERRsdevRVSVSNPGPGIPP 399
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 503802029  368 EALSRAFEPFYRAEPSR---PQGTGLGLSIVRRLCDRFGWKVSLASEPGK 414
Cdd:TIGR01386 400 EHLSRLFDRFYRVDPARsnsGEGTGLGLAIVRSIMEAHGGRASAESPDGK 449
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
324-423 2.71e-26

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 102.06  E-value: 2.71e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029  324 PRVLQVVVSNLVRNACSYT-DEGRIDVQVLND---RVVVRDTGIGMSAEALSRAFEPFYRAEPSRPQGTGLGLSIVRRLC 399
Cdd:pfam02518   3 ELRLRQVLSNLLDNALKHAaKAGEITVTLSEGgelTLTVEDNGIGIPPEDLPRIFEPFSTADKRGGGGTGLGLSIVRKLV 82
                          90       100
                  ....*....|....*....|....
gi 503802029  400 DRFGWKVSLASEPGKGTEATVIFR 423
Cdd:pfam02518  83 ELLGGTITVESEPGGGTTVTLTLP 106
HATPase_EvgS-ArcB-TorS-like cd16922
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ...
327-421 1.21e-25

Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340399 [Multi-domain]  Cd Length: 110  Bit Score: 100.26  E-value: 1.21e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 327 LQVVVSNLVRNACSYTDEGRID--VQVLND-------RVVVRDTGIGMSAEALSRAFEPFYRAEPS---RPQGTGLGLSI 394
Cdd:cd16922    1 LRQILLNLLGNAIKFTEEGEVTlrVSLEEEeedgvqlRFSVEDTGIGIPEEQQARLFEPFSQADSSttrKYGGTGLGLAI 80
                         90       100
                 ....*....|....*....|....*..
gi 503802029 395 VRRLCDRFGWKVSLASEPGKGTEATVI 421
Cdd:cd16922   81 SKKLVELMGGDISVESEPGQGSTFTFT 107
TMAO_torS TIGR02956
TMAO reductase sytem sensor TorS; This protein, TorS, is part of a regulatory system for the ...
193-417 8.65e-25

TMAO reductase sytem sensor TorS; This protein, TorS, is part of a regulatory system for the torCAD operon that encodes the pterin molybdenum cofactor-containing enzyme trimethylamine-N-oxide (TMAO) reductase (TorA), a cognate chaperone (TorD), and a penta-haem cytochrome (TorC). TorS works together with the inducer-binding protein TorT and the response regulator TorR. TorS contains histidine kinase ATPase (pfam02518), HAMP (pfam00672), phosphoacceptor (pfam00512), and phosphotransfer (pfam01627) domains and a response regulator receiver domain (pfam00072). [Signal transduction, Two-component systems]


Pssm-ID: 274362 [Multi-domain]  Cd Length: 968  Bit Score: 107.17  E-value: 8.65e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029  193 TRQLAAALHSLANRVSAH-----VARERN-----FTRDASHELRTPLTVIrVASDMALGDETLQPRLRRSLQRIQRAGRD 262
Cdd:TIGR02956 433 TQELAETNERLNAEVKNHakaraEAEEANraksaFLATMSHEIRTPLNGI-LGTLELLGDTGLTSQQQQYLQVINRSGES 511
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029  263 MEAVIDAFL----ILAREADVEPqiELFDVNDIvryeVDNANELLGNR--PVSVHLHSEGPVQLHA-----PPRVLQVVV 331
Cdd:TIGR02956 512 LLDILNDILdyskIEAGHLSISP--RPFDLNAL----LDDVHHLMVSRaqLKGIQLRLNIPEQLPNwwqgdGPRIRQVLI 585
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029  332 sNLVRNACSYTDEGRIDVQV-LND----RVVVRDTGIGMSAEALSRAFEPFYRAEPSRPQ-GTGLGLSIVRRLCDRFGWK 405
Cdd:TIGR02956 586 -NLVGNAIKFTDRGSVVLRVsLNDdsslLFEVEDTGCGIAEEEQATLFDAFTQADGRRRSgGTGLGLAISQRLVEAMDGE 664
                         250
                  ....*....|..
gi 503802029  406 VSLASEPGKGTE 417
Cdd:TIGR02956 665 LGVESELGVGSC 676
NtrB COG3852
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
223-422 1.09e-24

Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];


Pssm-ID: 443061 [Multi-domain]  Cd Length: 361  Bit Score: 104.16  E-value: 1.09e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 223 HELRTPLTVIRVASDMaLGDETLQPRLRRSLQRIQRAGRDMEAVIDAFLILAREAdvEPQIELFDVNDIVRYEVDNANEL 302
Cdd:COG3852  144 HEIRNPLTGIRGAAQL-LERELPDDELREYTQLIIEEADRLNNLVDRLLSFSRPR--PPEREPVNLHEVLERVLELLRAE 220
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 303 LGNRpVSVHLH---SEGPVQLHaPPRVLQVVVsNLVRNAC-SYTDEGRIDVQVLND--------------RVVVRDTGIG 364
Cdd:COG3852  221 APKN-IRIVRDydpSLPEVLGD-PDQLIQVLL-NLVRNAAeAMPEGGTITIRTRVErqvtlgglrprlyvRIEVIDNGPG 297
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 503802029 365 MSAEALSRAFEPFYRaepSRPQGTGLGLSIVRRLCDRFGWKVSLASEPGKGTEATVIF 422
Cdd:COG3852  298 IPEEILDRIFEPFFT---TKEKGTGLGLAIVQKIVEQHGGTIEVESEPGKGTTFRIYL 352
envZ PRK09467
osmolarity sensor protein; Provisional
222-422 1.35e-23

osmolarity sensor protein; Provisional


Pssm-ID: 236531 [Multi-domain]  Cd Length: 435  Bit Score: 101.91  E-value: 1.35e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 222 SHELRTPLTVIRVASDM-ALGDETLQprlrrslQRIQRAGRDMEAVIDAFLILAREaDVEPQIELFDVNDIVRyEVDNAN 300
Cdd:PRK09467 237 SHDLRTPLTRIRLATEMmSEEDGYLA-------ESINKDIEECNAIIEQFIDYLRT-GQEMPMEMADLNALLG-EVIAAE 307
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 301 ellGNRPVSVHLH-SEGPVQLHAPPRVLQVVVSNLVRNACSYTdEGRIDV--QVLNDRVV--VRDTGIGMSAEALSRAFE 375
Cdd:PRK09467 308 ---SGYEREIETAlQPGPIEVPMNPIAIKRALANLVVNAARYG-NGWIKVssGTEGKRAWfqVEDDGPGIPPEQLKHLFQ 383
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 503802029 376 PFYRAEPSR-PQGTGLGLSIVRRLCDRFGWKVSLASEPGKGTEATVIF 422
Cdd:PRK09467 384 PFTRGDSARgSSGTGLGLAIVKRIVDQHNGKVELGNSEEGGLSARAWL 431
KinE COG5809
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ...
222-422 2.67e-22

Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444511 [Multi-domain]  Cd Length: 489  Bit Score: 98.89  E-value: 2.67e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 222 SHELRTPLTVIRVASDMALGDETLQPRL-----RRSLQRIqragrdmEAVIDAFLILAReadvePQ---IELFDVNDIVR 293
Cdd:COG5809  278 AHEIRNPLTSLKGFIQLLKDTIDEEQKTyldimLSELDRI-------ESIISEFLVLAK-----PQaikYEPKDLNTLIE 345
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 294 YEVD--NANELLGNrpVSVHLHSEGPVqlhaPP------RVLQVVVsNLVRNACSYTDEG---RIDVQVLNDRVV---VR 359
Cdd:COG5809  346 EVIPllQPQALLKN--VQIELELEDDI----PDilgdenQLKQVFI-NLLKNAIEAMPEGgniTIETKAEDDDKVvisVT 418
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 503802029 360 DTGIGMSAEALSRAFEPFY-RAEpsrpQGTGLGLSIVRRLCDRFGWKVSLASEPGKGTEATVIF 422
Cdd:COG5809  419 DEGCGIPEERLKKLGEPFYtTKE----KGTGLGLMVSYKIIEEHGGKITVESEVGKGTTFSITL 478
phoR PRK11006
phosphate regulon sensor histidine kinase PhoR;
212-416 1.19e-21

phosphate regulon sensor histidine kinase PhoR;


Pssm-ID: 182895 [Multi-domain]  Cd Length: 430  Bit Score: 96.23  E-value: 1.19e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 212 AReRNFTRDASHELRTPLTVIRVASDMaLGDETLQPRLR-RSLQRIQRAGRDMEAVIDAFLILAR-EAdvEPQIELFDVN 289
Cdd:PRK11006 203 AR-RNFFANVSHELRTPLTVLQGYLEM-MQDQPLEGALReKALHTMREQTQRMEGLVKQLLTLSKiEA--APTIDLNEKV 278
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 290 DI------VRYEVdnanELLGNRPVSVHLHSEGPVQLHAPPRVLQVVVSNLVRNACSYTDEG-RIDVQVLND----RVVV 358
Cdd:PRK11006 279 DVpmmlrvLEREA----QTLSQGKHTITFEVDNSLKVFGNEDQLRSAISNLVYNAVNHTPEGtHITVRWQRVpqgaEFSV 354
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 503802029 359 RDTGIGMSAEALSRAFEPFYRAEPSRPQ---GTGLGLSIVRRLCDRFGWKVSLASEPGKGT 416
Cdd:PRK11006 355 EDNGPGIAPEHIPRLTERFYRVDKARSRqtgGSGLGLAIVKHALSHHDSRLEIESEVGKGT 415
PRK10755 PRK10755
two-component system sensor histidine kinase PmrB;
131-422 1.88e-21

two-component system sensor histidine kinase PmrB;


Pssm-ID: 236751 [Multi-domain]  Cd Length: 356  Bit Score: 94.65  E-value: 1.88e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 131 GIVPVLLTLLavygaswVTYRASKRLVSPVNWLARRVSRwdpghpEAADlepNKLPADMQGETRQLAA---ALHSLANRV 207
Cdd:PRK10755  67 SLVMVSLTLL-------ICFQAVRWITRPLAELQKELEA------RTAD---NLTPIAIHSSTLEIEAvtsALNQLVSRL 130
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 208 SAHVARERNFTRDASHELRTPLTVIRVasDMALGDETLQPRLRRSLQRIQRagrdMEAVIDAFLILAR--EADVEPQIEL 285
Cdd:PRK10755 131 TSTLDQERLFTADVAHELRTPLAGIRL--HLELLEKQHHIDVAPLIARLDQ----MMHTVEQLLQLARagQSFSSGHYQT 204
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 286 FD-VNDIVRYEVDNANELLGNRPVSVHL-HSEGPVQLHAPPRVLQVVVSNLVRNACSYTDEG-RIDVQVLND----RVVV 358
Cdd:PRK10755 205 VKlLEDVILPSQDELSEMLEQRQQTLLLpESAADITVQGDATLLRLLLRNLVENAHRYSPEGsTITIKLSQEdggaVLAV 284
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 503802029 359 RDTGIGMSAEALSRAFEPFYRAEpSRPQGTGLGLSIVRRLCDRFGWKVSLASEP-GKGTEATVIF 422
Cdd:PRK10755 285 EDEGPGIDESKCGELSKAFVRMD-SRYGGIGLGLSIVSRITQLHHGQFFLQNRQeRSGTRAWVWL 348
PRK11100 PRK11100
sensory histidine kinase CreC; Provisional
120-422 7.57e-21

sensory histidine kinase CreC; Provisional


Pssm-ID: 236846 [Multi-domain]  Cd Length: 475  Bit Score: 94.14  E-value: 7.57e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 120 RSRAEMLafWFGIVPVLLTLLAVYGASWVTYRASKRLVSPVNWLA--RRVSrwdpghpeaadlepnkLPADMQGETRQLA 197
Cdd:PRK11100 179 RSERRIL--WAGALLLGIALLIGAGVVWWLNRSIRRLTRYADAVTegKPVP----------------LPKLGSSELRELA 240
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 198 AALHSLANRVS--AHVARernFTRDASHELRTPLTVIRVASDMaLGDETLQPRLRRSLQRIQRAGRDMEAVIDAFLILAR 275
Cdd:PRK11100 241 QALESMRVKLEgkAYVEQ---YVQTLTHELKSPLAAIRGAAEL-LQEDPPPEDRARFTGNILTQSARLQQLIDRLLELAR 316
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 276 -EADVEPQ-IELFDVNDIVRYEVDNANELLGNRPVSVHLHSEgPVQLHAPPRVLQVVVSNLVRNACSYTDEG---RIDVQ 350
Cdd:PRK11100 317 lEQRQELEvLEPVALAALLEELVEAREAQAAAKGITLRLRPD-DARVLGDPFLLRQALGNLLDNAIDFSPEGgtiTLSAE 395
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 503802029 351 VLNDRV--VVRDTGIGMSAEALSRAFEPFY---RAEpSRPQGTGLGLSIVRRLCDRFGWKVSLASEPGKGTEATVIF 422
Cdd:PRK11100 396 VDGEQValSVEDQGPGIPDYALPRIFERFYslpRPA-NGRKSTGLGLAFVREVARLHGGEVTLRNRPEGGVLATLTL 471
PRK11360 PRK11360
two-component system sensor histidine kinase AtoS;
223-422 1.50e-20

two-component system sensor histidine kinase AtoS;


Pssm-ID: 236901 [Multi-domain]  Cd Length: 607  Bit Score: 93.88  E-value: 1.50e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 223 HELRTPLTVIRvASDMALGDETLQPRLRRSLQRIQRAGRDMEAVIDAFLILAREAdvEPQIELFDVNDIVRYEVDNANEL 302
Cdd:PRK11360 399 HEIRNPLTAIR-GYVQIWRQQTSDPPSQEYLSVVLREVDRLNKVIDQLLEFSRPR--ESQWQPVSLNALVEEVLQLFQTA 475
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 303 LGNRPVSVHLHSEGPVQL-HAPPRVLQVVVSNLVRNACSYTDEG---RIDVQVLNDR---VVVRDTGIGMSAEALSRAFE 375
Cdd:PRK11360 476 GVQARVDFETELDNELPPiWADPELLKQVLLNILINAVQAISARgkiRIRTWQYSDGqvaVSIEDNGCGIDPELLKKIFD 555
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 503802029 376 PFYraePSRPQGTGLGLSIVRRLCDRFGWKVSLASEPGKGTEATVIF 422
Cdd:PRK11360 556 PFF---TTKAKGTGLGLALSQRIINAHGGDIEVESEPGVGTTFTLYL 599
BaeS_SmeS NF012163
sensor histidine kinase efflux regulator BaeS;
129-422 1.59e-20

sensor histidine kinase efflux regulator BaeS;


Pssm-ID: 411086 [Multi-domain]  Cd Length: 457  Bit Score: 93.35  E-value: 1.59e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 129 WFGIVpVLLTLLAVYgASWVTYRA----SKRLVSPVNWLAR-----RVSRwdpghpeAADLEPNKLPADMQgetrQLAAA 199
Cdd:NF012163 166 SWLIV-ALALLLAAL-AAFLLARGllapVKRLVEATHRLAAgdyttRVTP-------TSNDELGKLAQDFN----QLAST 232
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 200 LHSlanrvsaHVARERNFTRDASHELRTPLTVIRvASDMALGDeTLQPRLRRSLQRIQRAGRDMEAVID--AFLILAREA 277
Cdd:NF012163 233 LEK-------NEQMRRDFMADISHELRTPLAVLR-AELEAIQD-GIRKFTPESLDSLQAEVGTLTKLVDdlHDLSMSDEG 303
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 278 DVEPQIELFDVNDIVRYEVDNANELLGNRPVSVHLHSEGPVQLHAPPRVLQVVVSNLVRNACSYTDE-GRIDVQVLND-- 354
Cdd:NF012163 304 ALAYQKASVDLVPLLEVEGGAFRERFASAGLELEVSLPDSSLVFGDRDRLMQLFNNLLENSLRYTDSgGSLHISASQRpk 383
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 503802029 355 --RVVVRDTGIGMSAEALSRAFEPFYRAEPSR---PQGTGLGLSIVRRLCDRFGWKVSLASEPGKGTEATVIF 422
Cdd:NF012163 384 evTLTVADSAPGVSDEQLARLFERFYRVEVSRnraSGGSGLGLAISLNIVQAHGGTLHAAHSPLGGLRIVVTL 456
HATPase_BasS-like cd16940
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
314-420 2.72e-20

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.


Pssm-ID: 340417 [Multi-domain]  Cd Length: 113  Bit Score: 85.54  E-value: 2.72e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 314 SEGPVQLHAPPRVLQVVVSNLVRNACSYTDEG-RIDVQVLNDR---VVVRDTGIGMSAEALSRAFEPFYRAEPSRPQGTG 389
Cdd:cd16940    1 SAADIQVQGDALLLFLLLRNLVDNAVRYSPQGsRVEIKLSADDgavIRVEDNGPGIDEEELEALFERFYRSDGQNYGGSG 80
                         90       100       110
                 ....*....|....*....|....*....|.
gi 503802029 390 LGLSIVRRLCDRFGWKVSLASEPGKGTEATV 420
Cdd:cd16940   81 LGLSIVKRIVELHGGQIFLGNAQGGGLEAWV 111
HK_WalK NF033092
cell wall metabolism sensor histidine kinase WalK; This model describes WalK as found in ...
215-422 5.31e-20

cell wall metabolism sensor histidine kinase WalK; This model describes WalK as found in Staphylococcus aureus (sp|Q2G2U4.1|WALK_STAA8). A shorter version, as found in Streptococcus pneumoniae, called WalK(Spn) or VicK, is not included. WalK is part of a two-component system and works with partner protein WalR.


Pssm-ID: 467964 [Multi-domain]  Cd Length: 594  Bit Score: 92.12  E-value: 5.31e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 215 RNFTRDASHELRTPLTVIR----VASDMALGDETLQPRLrrsLQRIQRAGRDMEAVIDAFLILAR--EADVEPQIELFDV 288
Cdd:NF033092 373 REFVANVSHELRTPLTTMRsyleALADGAWKDPELAPRF---LGVTQNETERMIRLVNDLLQLSRmdSKDYKLNKEWVNF 449
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 289 ND-----IVRYEVDNANE------LLGNRPVSVHLHsegpvqlhaPPRVLQvVVSNLVRNACSYT-DEGRIDVQVL--ND 354
Cdd:NF033092 450 NEffnyiIDRFEMILKNKnitfkrEFPKRDLWVEID---------TDKITQ-VLDNIISNAIKYSpEGGTITFRLLetHN 519
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 503802029 355 RVVVR--DTGIGMSAEALSRAFEPFYRAEP--SRPQ-GTGLGLSIVRRLCDRFGWKVSLASEPGKGTeaTVIF 422
Cdd:NF033092 520 RIIISisDQGLGIPKKDLDKIFDRFYRVDKarSRKMgGTGLGLAIAKEVVEAHGGRIWAESEEGKGT--TIYF 590
HATPase_AtoS-like cd16943
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
323-421 3.84e-19

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.


Pssm-ID: 340419 [Multi-domain]  Cd Length: 105  Bit Score: 82.08  E-value: 3.84e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 323 PPRVLQVVVsNLVRNACSYTDE-GRIDVQVLND----RVVVRDTGIGMSAEALSRAFEPFYRAEPSRpQGTGLGLSIVRR 397
Cdd:cd16943    1 PSQLNQVLL-NLLVNAAQAMEGrGRITIRTWAHvdqvLIEVEDTGSGIDPEILGRIFDPFFTTKPVG-EGTGLGLSLSYR 78
                         90       100
                 ....*....|....*....|....
gi 503802029 398 LCDRFGWKVSLASEPGKGTEATVI 421
Cdd:cd16943   79 IIQKHGGTIRVASVPGGGTRFTII 102
HATPase_BceS-YxdK-YvcQ-like cd16948
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
327-422 1.30e-18

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.


Pssm-ID: 340424 [Multi-domain]  Cd Length: 109  Bit Score: 80.79  E-value: 1.30e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 327 LQVVVSNLVRNACSYTDEG---RIDVQVLNDRVV--VRDTGIGMSAEALSRAFEPFYRAEPSRPQG--TGLGLSIVRRLC 399
Cdd:cd16948    6 LSFIIGQIVSNALKYSKQGgkiEIYSETNEQGVVlsIKDFGIGIPEEDLPRVFDKGFTGENGRNFQesTGMGLYLVKKLC 85
                         90       100
                 ....*....|....*....|...
gi 503802029 400 DRFGWKVSLASEPGKGTEATVIF 422
Cdd:cd16948   86 DKLGHKIDVESEVGEGTTFTITF 108
PRK09835 PRK09835
Cu(+)/Ag(+) sensor histidine kinase;
180-412 2.85e-18

Cu(+)/Ag(+) sensor histidine kinase;


Pssm-ID: 182101 [Multi-domain]  Cd Length: 482  Bit Score: 86.75  E-value: 2.85e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 180 LEPNKLPAdmqgETRQLAAALHSLANRVSAHVARERNFTRDASHELRTPLTVIRVASDMALGDETLQPRLRRSL------ 253
Cdd:PRK09835 232 LDPQTVPI----ELEQLVLSFNHMIERIEDVFTRQSNFSADIAHEIRTPITNLITQTEIALSQSRSQKELEDVLysnlee 307
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 254 -QRIQRAGRDMeavidAFLILAREADVEPQIELFDVNDIVRYEVDNANELLGNRPVSVHLHSEGPvQLHAPPRVLQVVVS 332
Cdd:PRK09835 308 lTRMAKMVSDM-----LFLAQADNNQLIPEKKMLDLADEVGKVFDFFEAWAEERGVELRFVGDPC-QVAGDPLMLRRAIS 381
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 333 NLVRNACSYTDEG-----RIDVQVLNDRVVVRDTGIGMSAEALSRAFEPFYRAEPSRP---QGTGLGLSIVRRLCDRFGW 404
Cdd:PRK09835 382 NLLSNALRYTPAGeaitvRCQEVDHQVQLVVENPGTPIAPEHLPRLFDRFYRVDPSRQrkgEGSGIGLAIVKSIVVAHKG 461

                 ....*...
gi 503802029 405 KVSLASEP 412
Cdd:PRK09835 462 TVAVTSDA 469
KinA COG5805
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ...
223-422 7.58e-18

Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444507 [Multi-domain]  Cd Length: 496  Bit Score: 85.55  E-value: 7.58e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 223 HELRTPLTVIR-VASDMALGDETLQPRLRRSLQRIQRagrdMEAVIDAFLILAReaDVEPQIELFDVNDIVRYEVD--NA 299
Cdd:COG5805  296 HEIRNPLTSIKgFLQLLQPGIEDKEEYFDIMLSELDR----IESIISEFLALAK--PQAVNKEKENINELIQDVVTllET 369
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 300 NELLGNrpVSVHLHSEGPVQ-LHAPPRVLQVVVSNLVRNAC-SYTDEGRIDVQV-LNDRVV---VRDTGIGMSAEALSRA 373
Cdd:COG5805  370 EAILHN--IQIRLELLDEDPfIYCDENQIKQVFINLIKNAIeAMPNGGTITIHTeEEDNSViirVIDEGIGIPEERLKKL 447
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 503802029 374 FEPFYraePSRPQGTGLGLSIVRRLCDRFGWKVSLASEPGKGTEATVIF 422
Cdd:COG5805  448 GEPFF---TTKEKGTGLGLMVSYKIIENHNGTIDIDSKVGKGTTFTITL 493
PRK11466 PRK11466
hybrid sensory histidine kinase TorS; Provisional
222-416 1.87e-17

hybrid sensory histidine kinase TorS; Provisional


Pssm-ID: 236914 [Multi-domain]  Cd Length: 914  Bit Score: 84.96  E-value: 1.87e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 222 SHELRTPLTVIrVASDMALGDETLQPRLRRSLQRIQRAGRDMEAVIDAFL----ILAREADVEPQIELFDVNDIVRYEVD 297
Cdd:PRK11466 452 SHEIRTPLYGI-LGTAQLLADNPALNAQRDDLRAITDSGESLLTILNDILdysaIEAGGKNVSVSDEPFEPRPLLESTLQ 530
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 298 NANELLGNRPVSV-HLHSEG-PVQLHAPPRVLQVVVSNLVRNACSYTDEGRIDVQVLNDR----VVVRDTGIGMSAEALS 371
Cdd:PRK11466 531 LMSGRVKGRPIRLaTDIADDlPTALMGDPRRIRQVITNLLSNALRFTDEGSIVLRSRTDGeqwlVEVEDSGCGIDPAKLA 610
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 503802029 372 RAFEPFYRAEPSRpQGTGLGLSIVRRLCDRFGWKVSLASEPGKGT 416
Cdd:PRK11466 611 EIFQPFVQVSGKR-GGTGLGLTISSRLAQAMGGELSATSTPEVGS 654
PRK10549 PRK10549
two-component system sensor histidine kinase BaeS;
136-422 4.51e-17

two-component system sensor histidine kinase BaeS;


Pssm-ID: 182539 [Multi-domain]  Cd Length: 466  Bit Score: 82.76  E-value: 4.51e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 136 LLTLLAVYgASWVTYRA----SKRLVSPVNWLArrvsrwdpghpeAADLEpNKLPADMQGETRQLAAALHSLANRVSAHV 211
Cdd:PRK10549 172 LSTLLAAL-ATFLLARGllapVKRLVEGTHKLA------------AGDFT-TRVTPTSRDELGRLAQDFNQLASTLEKNE 237
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 212 ARERNFTRDASHELRTPLTVIRvasdmalGD-ETLQPRLRR----SLQRIQRAGRDMEAVIDAF--LILAREADVEPQIE 284
Cdd:PRK10549 238 QMRRDFMADISHELRTPLAVLR-------GElEAIQDGVRKftpeSVASLQAEVGTLTKLVDDLhqLSLSDEGALAYRKT 310
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 285 LFDVNDIVRYEVDNANELLGNRPVSVHLHSEGPVQLHAPPRVLQVVVSNLVRNACSYTDEG---RIDVQVLNDRVVV--R 359
Cdd:PRK10549 311 PVDLVPLLEVAGGAFRERFASRGLTLQLSLPDSATVFGDPDRLMQLFNNLLENSLRYTDSGgslHISAEQRDKTLRLtfA 390
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 503802029 360 DTGIGMSAEALSRAFEPFYRAEPSRPQ---GTGLGLSIVRRLCDRFGWKVSLASEPGKGTEATVIF 422
Cdd:PRK10549 391 DSAPGVSDEQLQKLFERFYRTEGSRNRasgGSGLGLAICLNIVEAHNGRIIAAHSPFGGVSITVEL 456
PRK10841 PRK10841
two-component system sensor histidine kinase RcsC;
317-420 6.56e-17

two-component system sensor histidine kinase RcsC;


Pssm-ID: 182772 [Multi-domain]  Cd Length: 924  Bit Score: 83.10  E-value: 6.56e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 317 PVQLHAPPRVLQVVVSNLVRNACSYTDEGRIDVQVLNDR----VVVRDTGIGMSAEALSRAFEPFYRAEP---SRPQGTG 389
Cdd:PRK10841 553 PVALNGDPMRLQQVISNLLSNAIKFTDTGCIVLHVRVDGdylsFRVRDTGVGIPAKEVVRLFDPFFQVGTgvqRNFQGTG 632
                         90       100       110
                 ....*....|....*....|....*....|.
gi 503802029 390 LGLSIVRRLCDRFGWKVSLASEPGKGTEATV 420
Cdd:PRK10841 633 LGLAICEKLINMMDGDISVDSEPGMGSQFTI 663
PRK15347 PRK15347
two component system sensor kinase;
72-416 8.34e-17

two component system sensor kinase;


Pssm-ID: 237951 [Multi-domain]  Cd Length: 921  Bit Score: 82.77  E-value: 8.34e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029  72 YLLESGQSALSLPANLRN--LEPGFHELPkDDQLVLVDVRPAGRLYLVFLRSRA---EMLAFWFGIVPVLLTLLA--VYG 144
Cdd:PRK15347 234 TIPLSSNQLQKILNQLENvkLHDGWQQIP-DYLVLRTQLKGPGWQQVTLYPRRNlanEALKPALQQLPFALLILVllTSV 312
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 145 ASWVTYRaskRLVSPvnwLARRVSRWDPGHPEAadLEPnKLPADMQGETRQLAAALHSLANRVSAH-------VA---RE 214
Cdd:PRK15347 313 LFLLLRR---YLAKP---LWRFVDIINKTGPAA--LEP-RLPENRLDELGSIAKAYNQLLDTLNEQydtlenkVAertQA 383
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 215 RNFTRDA---------------SHELRTPLTVIrVASDMALGDETLQPRLRRSLQRIQRAGRDMEAVIDAFLILAR-EAD 278
Cdd:PRK15347 384 LAEAKQRaeqankrksehlttiSHEIRTPLNGV-LGALELLQNTPLTAEQMDLADTARQCTLSLLAIINNLLDFSRiESG 462
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 279 vepQIELfdvndivRYE-------VDNANELLGNRPVS------VHLHSEGPVQLHAPP-RVLQVVVsNLVRNACSYTDE 344
Cdd:PRK15347 463 ---QMTL-------SLEetallplLDQAMLTIQGPAQSksltlrTFVGAHVPLYLHLDSlRLRQILV-NLLGNAVKFTET 531
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 503802029 345 GRI--DVQVLNDRVV--VRDTGIGMSAEALSRAFEPFYRAEpSRPQGTGLGLSIVRRLCDRFGWKVSLASEPGKGT 416
Cdd:PRK15347 532 GGIrlRVKRHEQQLCftVEDTGCGIDIQQQQQIFTPFYQAD-THSQGTGLGLTIASSLAKMMGGELTLFSTPGVGS 606
PRK11107 PRK11107
hybrid sensory histidine kinase BarA; Provisional
222-416 2.13e-16

hybrid sensory histidine kinase BarA; Provisional


Pssm-ID: 236848 [Multi-domain]  Cd Length: 919  Bit Score: 81.43  E-value: 2.13e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 222 SHELRTPLT-VIRVASdmalgdETLQPRLRRS----LQRIQRAGRDMEAVIDAFLILAR-EADvepQIEL----FD---- 287
Cdd:PRK11107 301 SHELRTPLNgVIGFTR------QTLKTPLTPTqrdyLQTIERSANNLLAIINDILDFSKlEAG---KLVLenipFSlret 371
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 288 VNDIVRYEVDNAN----ELlgnrpvSVHLHSEGPVQLHAPPRVLQVVVSNLVRNACSYTDEGRIDVQV----LND----- 354
Cdd:PRK11107 372 LDEVVTLLAHSAHekglEL------TLNIDPDVPDNVIGDPLRLQQIITNLVGNAIKFTESGNIDILVelraLSNtkvql 445
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 503802029 355 RVVVRDTGIGMSAEALSRAFEPFYRAEPS---RPQGTGLGLSIVRRLCDRFGWKVSLASEPGKGT 416
Cdd:PRK11107 446 EVQIRDTGIGISERQQSQLFQAFRQADASisrRHGGTGLGLVITQKLVNEMGGDISFHSQPNRGS 510
PRK13837 PRK13837
two-component system VirA-like sensor kinase;
222-416 3.04e-16

two-component system VirA-like sensor kinase;


Pssm-ID: 237526 [Multi-domain]  Cd Length: 828  Bit Score: 80.88  E-value: 3.04e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 222 SHELRTPLTVIRVASDMALGDETLQPRLRRSLQRIQRAGRDMEAVIDAFLILAR--EADVEPqielFDVNDIVRYEVDNA 299
Cdd:PRK13837 458 AHNFNNILGAILGYAEMALNKLARHSRAARYIDEIISAGARARLIIDQILAFGRkgERNTKP----FDLSELVTEIAPLL 533
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 300 NELLGnRPVSVHLHSEG-PVQLHAPPRVLQVVVSNLVRNACSYTDE-GRIDVQVlnDRVVVR------------------ 359
Cdd:PRK13837 534 RVSLP-PGVELDFDQDQePAVVEGNPAELQQVLMNLCSNAAQAMDGaGRVDISL--SRAKLRapkvlshgvlppgryvll 610
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 360 ---DTGIGMSAEALSRAFEPFYraePSRPQGTGLGLSIVRRLCDRFGWKVSLASEPGKGT 416
Cdd:PRK13837 611 rvsDTGAGIDEAVLPHIFEPFF---TTRAGGTGLGLATVHGIVSAHAGYIDVQSTVGRGT 667
HATPase_CckA-like cd16919
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ...
327-422 1.54e-15

Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).


Pssm-ID: 340396 [Multi-domain]  Cd Length: 116  Bit Score: 72.41  E-value: 1.54e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 327 LQVVVSNLVRNAC-SYTDEGRIDVQVLNDRVV-------------------VRDTGIGMSAEALSRAFEPFYRAEPSrPQ 386
Cdd:cd16919    1 LELAILNLAVNARdAMPEGGRLTIETSNQRVDadyalnyrdlipgnyvcleVSDTGSGMPAEVLRRAFEPFFTTKEV-GK 79
                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 503802029 387 GTGLGLSIVRRLCDRFGWKVSLASEPGKGTEATVIF 422
Cdd:cd16919   80 GTGLGLSMVYGFVKQSGGHLRIYSEPGVGTTVRIYL 115
cpxA PRK09470
envelope stress sensor histidine kinase CpxA;
220-395 3.36e-15

envelope stress sensor histidine kinase CpxA;


Pssm-ID: 236532 [Multi-domain]  Cd Length: 461  Bit Score: 77.28  E-value: 3.36e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 220 DASHELRTPLTVIRVASdmALgdetlqprLRR------SLQRIQRAGRDMEAVIDAFLILAR-EADVEPQIELFDVNDI- 291
Cdd:PRK09470 249 DISHELRTPLTRLQLAT--AL--------LRRrqgeskELERIETEAQRLDSMINDLLVLSRnQQKNHLERETFKANSLw 318
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 292 ------VRYEVDNANELLgnrPVSVHLhseGPVQLHAPPRVLQVVVSNLVRNACSYT-DEGRIDVQVLND--RVVVRDTG 362
Cdd:PRK09470 319 sevledAKFEAEQMGKSL---TVSAPP---GPWPINGNPNALASALENIVRNALRYShTKIEVAFSVDKDglTITVDDDG 392
                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 503802029 363 IGMSAEALSRAFEPFYRAEPSRPQ---GTGLGLSIV 395
Cdd:PRK09470 393 PGVPEEEREQIFRPFYRVDEARDResgGTGLGLAIV 428
HATPase_HupT_MifS-like cd16976
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
327-421 1.02e-14

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.


Pssm-ID: 340435 [Multi-domain]  Cd Length: 102  Bit Score: 69.79  E-value: 1.02e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 327 LQVVVSNLVRNACSYT---DEGRIDV--QVLNDRVV--VRDTGIGMSAEALSRAFEPFYRAEPSrPQGTGLGLSIVRRLC 399
Cdd:cd16976    1 IQQVLMNLLQNALDAMgkvENPRIRIaaRRLGGRLVlvVRDNGPGIAEEHLSRVFDPFFTTKPV-GKGTGLGLSISYGIV 79
                         90       100
                 ....*....|....*....|..
gi 503802029 400 DRFGWKVSLASEPGKGTEATVI 421
Cdd:cd16976   80 EEHGGRLSVANEEGAGARFTFD 101
HATPase_FilI-like cd16921
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
327-422 1.16e-14

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340398 [Multi-domain]  Cd Length: 105  Bit Score: 69.66  E-value: 1.16e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 327 LQVVVSNLVRNACSYTDEG---RIDVQVLND----RVVVRDTGIGMSAEALSRAFEPFYRAEP-SRPQGTGLGLSIVRRL 398
Cdd:cd16921    1 LGQVLTNLLGNAIKFRRPRrppRIEVGAEDVgeewTFYVRDNGIGIDPEYAEKVFGIFQRLHSrEEYEGTGVGLAIVRKI 80
                         90       100
                 ....*....|....*....|....
gi 503802029 399 CDRFGWKVSLASEPGKGTeaTVIF 422
Cdd:cd16921   81 IERHGGRIWLESEPGEGT--TFYF 102
HATPase_EcPhoR-like cd16952
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
327-422 1.32e-14

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.


Pssm-ID: 340428 [Multi-domain]  Cd Length: 108  Bit Score: 69.54  E-value: 1.32e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 327 LQVVVSNLVRNACSYT-DEGRIDVQVLND----RVVVRDTGIGMSAEALSRAFEPFYRAEPSRPQ---GTGLGLSIVRRL 398
Cdd:cd16952    1 LRSAFSNLVSNAVKYTpPSDTITVRWSQEesgaRLSVEDTGPGIPPEHIPRLTERFYRVDIERCRntgGTGLGLAIVKHV 80
                         90       100
                 ....*....|....*....|....
gi 503802029 399 CDRFGWKVSLASEPGKGTEATVIF 422
Cdd:cd16952   81 MSRHDARLLIASELGKGSRFTCLF 104
PRK09959 PRK09959
acid-sensing system histidine kinase EvgS;
192-420 6.46e-14

acid-sensing system histidine kinase EvgS;


Pssm-ID: 182169 [Multi-domain]  Cd Length: 1197  Bit Score: 74.00  E-value: 6.46e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029  192 ETRQLAAALHSLANR-VSAHVARERnFTRDASHELRTPLTVIRVASDMALGDETLQPRLRRSLQRIQRAGRDMEAVIDAF 270
Cdd:PRK09959  690 ETRDLIHALEVERNKaINATVAKSQ-FLATMSHEIRTPISSIMGFLELLSGSGLSKEQRVEAISLAYATGQSLLGLIGEI 768
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029  271 LILAR--EADVEPQIELFDVNDIVRYEVDNANELLGNRPVSVHLHSEGPVQ--LHAPPRVLQVVVSNLVRNACSYTDEGR 346
Cdd:PRK09959  769 LDVDKieSGNYQLQPQWVDIPTLVQNTCHSFGAIAASKSIALSCSSTFPDHylVKIDPQAFKQVLSNLLSNALKFTTEGA 848
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029  347 IDVQV----LND-----RVVVRDTGIGMSAEALSRAFEPFYRAEPSRPQ-GTGLGLSIVRRLCDRFGWKVSLASEPGKGT 416
Cdd:PRK09959  849 VKITTslghIDDnhaviKMTIMDSGSGLSQEEQQQLFKRYSQTSAGRQQtGSGLGLMICKELIKNMQGDLSLESHPGIGT 928

                  ....
gi 503802029  417 EATV 420
Cdd:PRK09959  929 TFTI 932
PRK10604 PRK10604
sensor protein RstB; Provisional
196-423 1.51e-13

sensor protein RstB; Provisional


Pssm-ID: 236724 [Multi-domain]  Cd Length: 433  Bit Score: 71.94  E-value: 1.51e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 196 LAAALHSLANRVSAHVARERNFTRDASHELRTPLTVIRVASDMaLGDETLQPRlrrslQRIQRAGRDMEAVIDAFLILAR 275
Cdd:PRK10604 194 LGVAFNQMADNINALIASKKQLIDGIAHELRTPLVRLRYRLEM-SDNLSAAES-----QALNRDIGQLEALIEELLTYAR 267
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 276 --EADVEPQIELFDVNDIVRYEVDNANelLGNRPVSVHLHSEGPVQ-LHAPPRVLQVVVSNLVRNACSYTdEGRIDVQVL 352
Cdd:PRK10604 268 ldRPQNELHLSEPDLPAWLSTHLADIQ--AVTPEKTVRLDTPHQGDyGALDMRLMERVLDNLLNNALRYA-HSRVRVSLL 344
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 503802029 353 ND----RVVVRDTGIGMSAEALSRAFEPFYRAEPSRPQGT---GLGLSIVRRLCDRFGWKVSLASEPGKGteATVIFR 423
Cdd:PRK10604 345 LDgnqaCLIVEDDGPGIPPEERERVFEPFVRLDPSRDRATggcGLGLAIVHSIALAMGGSVNCDESELGG--ARFSFS 420
HATPase_BaeS-like cd16946
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
324-422 2.67e-13

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.


Pssm-ID: 340422 [Multi-domain]  Cd Length: 109  Bit Score: 65.95  E-value: 2.67e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 324 PRVLQVVVSNLVRNACSYTDEG-RIDVQVLND----RVVVRDTGIGMSAEALSRAFEPFYRAEPSRPQ---GTGLGLSIV 395
Cdd:cd16946    2 RDRLQQLFVNLLENSLRYTDTGgKLRIRAAQTpqevRLDVEDSAPGVSDDQLARLFERFYRVESSRNRasgGSGLGLAIC 81
                         90       100
                 ....*....|....*....|....*..
gi 503802029 396 RRLCDRFGWKVSLASEPGKGTEATVIF 422
Cdd:cd16946   82 HNIALAHGGTISAEHSPLGGLRLVLTL 108
HATPase_EnvZ-like cd16950
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
327-420 6.61e-13

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.


Pssm-ID: 340426 [Multi-domain]  Cd Length: 101  Bit Score: 64.39  E-value: 6.61e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 327 LQVVVSNLVRNACSYtdeGRIDVQVLND------RVVVRDTGIGMSAEALSRAFEPFYRAEPSR-PQGTGLGLSIVRRLC 399
Cdd:cd16950    1 LKRVLSNLVDNALRY---GGGWVEVSSDgegnrtRIQVLDNGPGIAPEEVDELFQPFYRGDNARgTSGTGLGLAIVQRIS 77
                         90       100
                 ....*....|....*....|.
gi 503802029 400 DRFGWKVSLASEPGKGTEATV 420
Cdd:cd16950   78 DAHGGSLTLANRAGGGLCARI 98
PRK11091 PRK11091
aerobic respiration control sensor protein ArcB; Provisional
222-420 7.32e-13

aerobic respiration control sensor protein ArcB; Provisional


Pssm-ID: 236842 [Multi-domain]  Cd Length: 779  Bit Score: 70.35  E-value: 7.32e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 222 SHELRTPLTVIRVASDMALgDETLQPRLRRSLQRIQRA----GRDMEAVIDAFLILAREADVEPQIelFDVNDIVRyEVD 297
Cdd:PRK11091 291 SHELRTPLNGIVGLSRILL-DTELTAEQRKYLKTIHVSaitlGNIFNDIIDMDKMERRKLQLDNQP--IDFTDFLA-DLE 366
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 298 NANELLGnRPVSVHLHSEgpVQLHAPPRV------LQVVVSNLVRNACSYTDEGRIDVQVL---NDRV--VVRDTGIGMS 366
Cdd:PRK11091 367 NLSGLQA-EQKGLRFDLE--PLLPLPHKVitdgtrLRQILWNLISNAVKFTQQGGVTVRVRyeeGDMLtfEVEDSGIGIP 443
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 503802029 367 AEALSRAFEPFYRAEPS---RPQ-GTGLGLSIVRRLCDRFGWKVSLASEPGKGTEATV 420
Cdd:PRK11091 444 EDELDKIFAMYYQVKDShggKPAtGTGIGLAVSKRLAQAMGGDITVTSEEGKGSCFTL 501
HATPase_YcbM-like cd16947
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
315-420 1.10e-12

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).


Pssm-ID: 340423 [Multi-domain]  Cd Length: 125  Bit Score: 64.46  E-value: 1.10e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 315 EGPVQLHAPPRVLQVVVSNLVRNACSYTDEGRIDVQVLNDR-----VVVRDTGIGMSAEALSRAFEPFYRAEPSRP---Q 386
Cdd:cd16947    9 DRPIYANANTEALQRILKNLISNAIKYGSDGKFLGMTLREDekhvyIDIWDKGKGISETEKDHVFERLYTLEDSRNsakQ 88
                         90       100       110
                 ....*....|....*....|....*....|....
gi 503802029 387 GTGLGLSIVRRLCDRFGWKVSLASEPGKGTEATV 420
Cdd:cd16947   89 GNGLGLTITKRLAESMGGSIYVNSKPYEKTVFTV 122
HisKA pfam00512
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ...
215-275 1.22e-12

His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.


Pssm-ID: 459839 [Multi-domain]  Cd Length: 66  Bit Score: 62.61  E-value: 1.22e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 503802029  215 RNFTRDASHELRTPLTVIRVASDMaLGDETLQPRLRRSLQRIQRAGRDMEAVIDAFLILAR 275
Cdd:pfam00512   3 SEFLANLSHELRTPLTAIRGYLEL-LRDEKLDEEQREYLETILRSAERLLRLINDLLDLSR 62
HisKA cd00082
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ...
212-275 1.66e-12

Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.


Pssm-ID: 119399 [Multi-domain]  Cd Length: 65  Bit Score: 62.23  E-value: 1.66e-12
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 503802029 212 ARERNFTRDASHELRTPLTVIRVASDMALGDETLQPRLRRSLQRIQRAGRDMEAVIDAFLILAR 275
Cdd:cd00082    2 QAKGEFLANVSHELRTPLTAIRGALELLEEELLDDEEQREYLERIREEAERLLRLINDLLDLSR 65
HATPase_SpaK_NisK-like cd16975
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
330-420 3.14e-12

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.


Pssm-ID: 340434 [Multi-domain]  Cd Length: 107  Bit Score: 62.86  E-value: 3.14e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 330 VVSNLVRNACSYTDEGR-IDVQVLNDR----VVVRDTGIGMSAEALSRAFEPFYRAEPSRPQGT--GLGLSIVRRLCDRF 402
Cdd:cd16975    8 ALINIISNACQYAPEGGtVSISIYDEEeylyFEIWDNGHGFSEQDLKKALELFYRDDTSRRSGGhyGMGLYIAKNLVEKH 87
                         90
                 ....*....|....*...
gi 503802029 403 GWKVSLASEPGKGTEATV 420
Cdd:cd16975   88 GGSLIIENSQKGGAEVTV 105
PRK10364 PRK10364
two-component system sensor histidine kinase ZraS;
222-420 3.72e-12

two-component system sensor histidine kinase ZraS;


Pssm-ID: 236674 [Multi-domain]  Cd Length: 457  Bit Score: 67.89  E-value: 3.72e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 222 SHELRTPLTVIR-----VASDMALGDET--LQPRLRRSLQRIQRagrdmeaVIDAFLILAREADVEPQIelFDVNDIVRY 294
Cdd:PRK10364 245 AHEIRNPLSSIKglakyFAERAPAGGEAhqLAQVMAKEADRLNR-------VVSELLELVKPTHLALQA--VDLNDLINH 315
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 295 EVDNANELLGNRPVSVHLH-SEGPVQLHA-PPRVLQVVVsNLVRNACSYTDE-GRIDVQV--LNDRV--VVRDTGIGMSA 367
Cdd:PRK10364 316 SLQLVSQDANSREIQLRFTaNDTLPEIQAdPDRLTQVLL-NLYLNAIQAIGQhGVISVTAseSGAGVkiSVTDSGKGIAA 394
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 503802029 368 EALSRAFEPFYraePSRPQGTGLGLSIVRRLCDRFGWKVSLASEPGKGTEATV 420
Cdd:PRK10364 395 DQLEAIFTPYF---TTKAEGTGLGLAVVHNIVEQHGGTIQVASQEGKGATFTL 444
PRK09303 PRK09303
histidine kinase;
223-415 3.73e-12

histidine kinase;


Pssm-ID: 236462 [Multi-domain]  Cd Length: 380  Bit Score: 67.28  E-value: 3.73e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 223 HELRTPLTvirvASDMALgdETLQ-----------PRLRRSLQR-IQRAGRDMEAVIDAFLILAR----EADVEPQ-IEL 285
Cdd:PRK09303 160 HDLRTPLT----AASLAL--ETLElgqidedtelkPALIEQLQDqARRQLEEIERLITDLLEVGRtrweALRFNPQkLDL 233
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 286 FDVNDIVRYEVdnaNELLGNRpvSVHLHSEGPVQL---HAPPRVLQVVVSNLVRNACSYT-DEGRIDVQVLnDR------ 355
Cdd:PRK09303 234 GSLCQEVILEL---EKRWLAK--SLEIQTDIPSDLpsvYADQERIRQVLLNLLDNAIKYTpEGGTITLSML-HRttqkvq 307
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 503802029 356 VVVRDTGIGMSAEALSRAFEPFYRAEPSRPQ-GTGLGLSIVRRLCDRFGWKVSLASEPGKG 415
Cdd:PRK09303 308 VSICDTGPGIPEEEQERIFEDRVRLPRDEGTeGYGIGLSVCRRIVRVHYGQIWVDSEPGQG 368
HATPase_TmoS-FixL-DctS-like cd16920
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
327-416 1.49e-11

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340397 [Multi-domain]  Cd Length: 104  Bit Score: 60.87  E-value: 1.49e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 327 LQVVVSNLVRNACSYTDEGRIDVQVLNDR----------VVVRDTGIGMSAEALSRAFEPFYraePSRPQGTGLGLSIVR 396
Cdd:cd16920    1 IQQVLINLVRNGIEAMSEGGCERRELTIRtspaddravtISVKDTGPGIAEEVAGQLFDPFY---TTKSEGLGMGLSICR 77
                         90       100
                 ....*....|....*....|
gi 503802029 397 RLCDRFGWKVSLASEPGKGT 416
Cdd:cd16920   78 SIIEAHGGRLSVESPAGGGA 97
HisKA smart00388
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ...
215-275 1.80e-11

His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.


Pssm-ID: 214644 [Multi-domain]  Cd Length: 66  Bit Score: 59.12  E-value: 1.80e-11
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 503802029   215 RNFTRDASHELRTPLTVIRVASDMaLGDETLQPRLRRSLQRIQRAGRDMEAVIDAFLILAR 275
Cdd:smart00388   3 REFLANLSHELRTPLTAIRGYLEL-LLDTELSEEQREYLETILREAERLLRLINDLLDLSR 62
YesM COG2972
Sensor histidine kinase YesM [Signal transduction mechanisms];
118-422 2.05e-11

Sensor histidine kinase YesM [Signal transduction mechanisms];


Pssm-ID: 442211 [Multi-domain]  Cd Length: 445  Bit Score: 65.42  E-value: 2.05e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 118 FLRSRAEMLAFWFGIVPVLLTLLAVygasWVTYRASKRLVSPVNWLARRVSRWDPGHPEAADLEPNKlpadmqgETRQLA 197
Cdd:COG2972  147 ELFRGLFSLRRLILLIILLLLLLAL----LLSYLLSRSITRPIKRLKKAMKKVEKGDLVRLEVSGND-------EIGILA 215
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 198 AALHSLANRVSAHVARERNFTRDASH-ELRTpltvirvasdmalgdetLQPRLRR-----SLQRIQRAGR--DMEAVIDA 269
Cdd:COG2972  216 RSFNEMVERIKELIEEVYELELEKKEaELKA-----------------LQAQINPhflfnTLNSIRWLAEleDPEEAEEM 278
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 270 FLILAReadvepqieLF-----DVNDIV--RYEVDNANELL-------GNRpVSVHLH-SEGPVQLHAPPRVLQVvvsnL 334
Cdd:COG2972  279 LEALSK---------LLryslsKGDELVtlEEELELIKSYLeiqklrfGDR-LEVEIEiDEELLDLLIPKLILQP----L 344
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 335 VRNAC-----SYTDEGRIDVQVLND----RVVVRDTGIGMSAEALSRAFEPFyraePSRPQGTGLGLSIVR-RLCDRFG- 403
Cdd:COG2972  345 VENAIehgiePKEGGGTIRISIRKEgdrlVITVEDNGVGMPEEKLEKLLEEL----SSKGEGRGIGLRNVReRLKLYYGe 420
                        330       340
                 ....*....|....*....|
gi 503802029 404 -WKVSLASEPGKGTEATVIF 422
Cdd:COG2972  421 eYGLEIESEPGEGTTVTIRI 440
CitA COG3290
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ...
192-422 1.28e-10

Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];


Pssm-ID: 442519 [Multi-domain]  Cd Length: 389  Bit Score: 62.56  E-value: 1.28e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 192 ETRQLAAALHSLANRVSAhvarernfTRDASHELRTPLTVIRVASDMALGDETLQpRLRRSLQRIQRAGRDM-----EAV 266
Cdd:COG3290  175 ELERLEEELEGVKELAEA--------LRAQRHDFRNHLHTISGLLQLGEYDEALE-YIDEISEELQELIDSLlsrigNPV 245
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 267 IDAFLI----LAREADVEpqielfdvndivryevdnanellgnrpVSVHLHSEGPvQLHAPPRVLQVVVSNLVRNA---- 338
Cdd:COG3290  246 LAALLLgkaaRARERGID---------------------------LTIDIDSDLP-DLPLSDTDLVTILGNLLDNAieav 297
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 339 -CSYTDEGRIDVQVLND----RVVVRDTGIGMSAEALSRAFEPFYraePSRP-QGTGLGLSIVRRLCDRFGWKVSLASEP 412
Cdd:COG3290  298 eKLPEEERRVELSIRDDgdelVIEVEDSGPGIPEELLEKIFERGF---STKLgEGRGLGLALVKQIVEKYGGTIEVESEE 374
                        250
                 ....*....|
gi 503802029 413 GKGTEATVIF 422
Cdd:COG3290  375 GEGTVFTVRL 384
HATPase_NtrY-like cd16944
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
325-422 4.26e-10

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.


Pssm-ID: 340420 [Multi-domain]  Cd Length: 108  Bit Score: 56.78  E-value: 4.26e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 325 RVLQVVVSNLVRNACSYTD-------EGRIDV---QVLNDRVVVRDTGIGMSAEALSRAFEPFYraePSRPQGTGLGLSI 394
Cdd:cd16944    3 TQISQVLTNILKNAAEAIEgrpsdvgEVRIRVeadQDGRIVLIVCDNGKGFPREMRHRATEPYV---TTRPKGTGLGLAI 79
                         90       100
                 ....*....|....*....|....*...
gi 503802029 395 VRRLCDRFGWKVSLASEPGKGTEATVIF 422
Cdd:cd16944   80 VKKIMEEHGGRISLSNREAGGACIRIIL 107
HATPase_CpxA-like cd16949
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
333-421 6.60e-10

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.


Pssm-ID: 340425 [Multi-domain]  Cd Length: 104  Bit Score: 56.18  E-value: 6.60e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 333 NLVRNACSYTDEG-RIDVQVLNDRVV--VRDTGIGMSAEALSRAFEPFYRAEPSRPQ---GTGLGLSIVRRLCDRFGWKV 406
Cdd:cd16949    7 NVLRNALRYSPSKiLLDISQDGDQWTitITDDGPGVPEDQLEQIFLPFYRVDSARDResgGTGLGLAIAERAIEQHGGKI 86
                         90
                 ....*....|....*
gi 503802029 407 SLASEPGKGTEATVI 421
Cdd:cd16949   87 KASNRKPGGLRVRIW 101
HATPase_Glnl-NtrB-like cd16918
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
327-413 8.85e-10

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).


Pssm-ID: 340395 [Multi-domain]  Cd Length: 109  Bit Score: 55.87  E-value: 8.85e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 327 LQVVVSNLVRNACSYTDEG--------RIDVQV--------LNDRVVVRDTGIGMSAEALSRAFEPFYRaepSRPQGTGL 390
Cdd:cd16918    1 LIQVFLNLVRNAAQALAGSggeiilrtRTQRQVtlghprhrLALRVSVIDNGPGIPPDLQDTIFYPMVS---GRENGTGL 77
                         90       100
                 ....*....|....*....|...
gi 503802029 391 GLSIVRRLCDRFGWKVSLASEPG 413
Cdd:cd16918   78 GLAIAQNIVSQHGGVIECDSQPG 100
HATPase_RstB-like cd16939
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
327-412 1.00e-09

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.


Pssm-ID: 340416 [Multi-domain]  Cd Length: 104  Bit Score: 55.51  E-value: 1.00e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 327 LQVVVSNLVRNACSYTDEgRIDVQVLND----RVVVRDTGIGMSAEALSRAFEPFYRAEPSRPQGT---GLGLSIVRRLC 399
Cdd:cd16939    1 MARALDNLLRNALRYAHR-TVRIALLVSggrlTLIVEDDGPGIPAAARERVFEPFVRLDPSRDRATggfGLGLAIVHRVA 79
                         90
                 ....*....|...
gi 503802029 400 DRFGWKVSLASEP 412
Cdd:cd16939   80 LWHGGHVECDDSE 92
HATPase_YpdA-YehU-LytS-like cd16924
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
323-421 1.06e-09

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YpdA, YehU, Bacillus subtilis LytS, and some hybrid sensor histidine kinases; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. It also includes the HATPase domains of Escherichia coli YpdA and YehU, HKs of YpdA-YpdB and YehU-YehTCSs, which are involved together in a nutrient sensing regulatory network. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), some having accessory sensor domain(s) such as Cache, HAMP or GAF; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340401 [Multi-domain]  Cd Length: 103  Bit Score: 55.53  E-value: 1.06e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 323 PPRVLQVVVSNLVRNACS-YTDEGRIDVQVLND----RVVVRDTGIGMSAEALSrafepfyRAEPSRPQGTGLGLSIVR- 396
Cdd:cd16924    2 PPFTLQPLVENAIQHGLSpLTDKGVVTISALKEdnhvMIEVEDNGRGIDPKVLN-------ILGKKPKEGNGIGLYNVHq 74
                         90       100
                 ....*....|....*....|....*..
gi 503802029 397 RLCDRFG--WKVSLASEPGKGTEATVI 421
Cdd:cd16924   75 RLILLFGedYGIHIASEPDKGTRITFT 101
COG4192 COG4192
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ...
132-421 1.48e-09

Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];


Pssm-ID: 443346 [Multi-domain]  Cd Length: 640  Bit Score: 60.09  E-value: 1.48e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 132 IVPVLLTLLAVYGASWvtYRASKRLVSPVNWLARRVSRWDPGHPEAadlepnKLPADMQGE-----------TRQLAAAL 200
Cdd:COG4192  329 LAIALLSLLLAVLINY--FYVRRRLVKRLNALSDAMAAIAAGDLDV------PIPVDGNDEigriarllrvfRDQAIEKT 400
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 201 HSLANRVSAHVARERN--------------------FTRDAsHELRTPLTVIRV---ASDMALGDETLQpRLRRSLQRIQ 257
Cdd:COG4192  401 QELETEIEERKRIEKNlrqtqdeliqaakmavvgqtMTSLA-HELNQPLNAMSMylfSAKKALEQENYA-QLPTSLDKIE 478
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 258 RAGRDMEAVIDAFLILAREADVEPQieLFDVNDIVryevDNANELLGNR--PVSVHLHSEGPVQLHAPPRVLQVVVSNLV 335
Cdd:COG4192  479 GLIERMDKIIKSLRQFSRKSDTPLQ--PVDLRQVI----EQAWELVESRakPQQITLHIPDDLMVQGDQVLLEQVLVNLL 552
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 336 RNAC-SYTDEGRIDVQVL----NDRVVVRDTGIGMS-AEALsraFEPFYraePSRPQGTGLGLSIVRRLCDRFGWKVSLA 409
Cdd:COG4192  553 VNALdAVATQPQISVDLLsnaeNLRVAISDNGNGWPlVDKL---FTPFT---TTKEVGLGLGLSICRSIMQQFGGDLYLA 626
                        330
                 ....*....|..
gi 503802029 410 SEPGKGteATVI 421
Cdd:COG4192  627 STLERG--AMVI 636
PRK10815 PRK10815
two-component system sensor histidine kinase PhoQ;
122-423 2.23e-09

two-component system sensor histidine kinase PhoQ;


Pssm-ID: 182754 [Multi-domain]  Cd Length: 485  Bit Score: 59.26  E-value: 2.23e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 122 RAEMLAFWFGIVpVLLTLLAVYGASWVTYRASKRlvsPVNWLARRVSRWDPGHPEAADLEPnklPADMQGETRQLAAALH 201
Cdd:PRK10815 185 RSYMVWSWFSYV-LLANLLLVIPLLWLAAWWSLR---PIEALAKQVRELEEGEREQLDPNP---PRELTSLVRNLNRLLK 257
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 202 SLANRVSahvaRERNFTRDASHELRTPLTVirvasdmalgdetLQPRLRrSLqriqRAGRDMEavIDaflilareaDVEP 281
Cdd:PRK10815 258 NERERYT----KYRTTLTDLTHSLKTPLAV-------------LQSTLR-SL----RSGKQMS--VE---------QAEP 304
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 282 qIELFDVNDI---VRYEVDNANELLGNRPVSVHLHSEGP-------------------VQLHAPPRVLQV--------VV 331
Cdd:PRK10815 305 -IMLEQISRIsqqIGYYLHRASMRSEHNLLSRELHSVAPlldnltsalnkvyqrkgvnITLDISPEITFVgekndfmeVM 383
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 332 SNLVRNACSYTDEG-RIDVQVLND--RVVVRDTGIGMSAEALSRAFEPFYRAEPSRPqGTGLGLSIVRRLCDRFGWKVSL 408
Cdd:PRK10815 384 GNVLDNACKYCLEFvEISARQTDEhlHIVVEDDGPGIPESKRELIFDRGQRADTLRP-GQGLGLSVAREITEQYEGKISA 462
                        330
                 ....*....|....*
gi 503802029 409 ASEPGKGTEATVIFR 423
Cdd:PRK10815 463 GDSPLGGARMEVIFG 477
HATPase_TutC-TodS-like cd16925
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ...
324-420 5.14e-09

Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.


Pssm-ID: 340402 [Multi-domain]  Cd Length: 110  Bit Score: 53.65  E-value: 5.14e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 324 PRVLQVVVSNLVRNACSYT-DEGRIDVQVLNDR-----VVVRDTGIGMSAEALSRAFEPFYRAEPSRPQ---GTGLGLSI 394
Cdd:cd16925    2 AEKYERVVLNLLSNAFKFTpDGGRIRCILEKFRlnrflLTVSDSGPGIPPNLREEIFERFRQGDGSSTRahgGTGLGLSI 81
                         90       100
                 ....*....|....*....|....*.
gi 503802029 395 VRRLCDRFGWKVSLASEPGKGTEATV 420
Cdd:cd16925   82 VKEFVELHGGTVTVSDAPGGGALFQV 107
HATPase_VanS-like cd16923
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
327-396 9.40e-09

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.


Pssm-ID: 340400 [Multi-domain]  Cd Length: 102  Bit Score: 52.77  E-value: 9.40e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 503802029 327 LQVVVSNLVRNACSYTDEG---RIDVQVLNDRVVVR--DTGIGMSAEALSRAFEPFYRAEPSR-PQGTGLGLSIVR 396
Cdd:cd16923    1 LQRVFSNLLSNAIKYSPENtriYITSFLTDDVVNIMfkNPSSHPLDFKLEKLFERFYRGDNSRnTEGAGLGLSIAK 76
ActS_PrrB_HisK NF033792
ActS/PrrB/RegB family redox-sensitive histidine kinase; This redox-responsive histidine kinase, ...
221-421 1.34e-08

ActS/PrrB/RegB family redox-sensitive histidine kinase; This redox-responsive histidine kinase, found in alpha-proteobacteria, shows strong sequence conservation, including the notable motif [VA]AAAAHELGTPxTI. It always acts as a partner to an ActR/PrrA/RegA family global response regulator transcription factor in a two-component sensory transduction system. Lineage-specific names and gene symbols given to this histidine kinase reflect downstream regulator changes such as entry into stationary phase, anaerobic expression of photosynthesis genes, and survival of exposure to low pH.


Pssm-ID: 468186 [Multi-domain]  Cd Length: 423  Bit Score: 56.37  E-value: 1.34e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 221 ASHELRTPLTVIR-VASDMA--LGD-----ETLQ------PRLRRSLQRIQRAGRDMEAVID--AFLILAREAdVEPQIE 284
Cdd:NF033792 209 AAHELGTPLATIAlVAKELEreLPDdpplrEDAEllrsqaERCRDILRRLTSLGEEGDAHLDrlPLSALIEEA-AAPHRG 287
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 285 lFDVNDIVRYEVDNANELLGNRPVSVhlhsegpvqLHApprvlqvvVSNLVRNACSY-TDEGRIDVQVLNDRV--VVRDT 361
Cdd:NF033792 288 -FGKEIEVVVAGDPGEEPVIRRNPEI---------LYG--------LGNLIENAVDFaRSTVTVTASWDAESVtiTIEDD 349
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 503802029 362 GIGMSAEALSRAFEPFY---RAEPSRP--QGTGLGLSIVRRLCDRFGWKVSLA--SEPGKGTEATVI 421
Cdd:NF033792 350 GPGFPPDVLSRIGEPYVttrRGEERRPggGGLGLGLFIAKTLLERSGATVTFAnrPPPEGGAVVTVR 416
HATPase_CreC-like cd16945
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
324-419 2.70e-08

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.


Pssm-ID: 340421 [Multi-domain]  Cd Length: 106  Bit Score: 51.69  E-value: 2.70e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 324 PRVLQVVVSNLVRNACSYTDEG---RIDVQVLND--RVVVRDTGIGMSAEALSRAFEPFYR-AEPSRPQ-GTGLGLSIVR 396
Cdd:cd16945    2 PFLLRQAINNLLDNAIDFSPEGgliALQLEADTEgiELLVFDEGSGIPDYALNRVFERFYSlPRPHSGQkSTGLGLAFVQ 81
                         90       100
                 ....*....|....*....|...
gi 503802029 397 RLCDRFGWKVSLASEPGkGTEAT 419
Cdd:cd16945   82 EVAQLHGGRITLRNRPD-GVLAF 103
RsbW COG2172
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
327-423 3.86e-08

Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];


Pssm-ID: 441775 [Multi-domain]  Cd Length: 127  Bit Score: 51.45  E-value: 3.86e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 327 LQVVVSNLVRNACSYTD----EGRIDVQVLND----RVVVRDTGIGMSAEALSRAFEPfyraepsrPQGTGLGLSIVRRL 398
Cdd:COG2172   35 LVLAVSEAVTNAVRHAYggdpDGPVEVELELDpdglEIEVRDEGPGFDPEDLPDPYST--------LAEGGRGLFLIRRL 106
                         90       100
                 ....*....|....*....|....*
gi 503802029 399 CDRFGWKvslaSEPGkGTEATVIFR 423
Cdd:COG2172  107 MDEVEYE----SDPG-GTTVRLVKR 126
HATPase_PhoQ-like cd16954
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
318-422 6.92e-08

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.


Pssm-ID: 340430 [Multi-domain]  Cd Length: 135  Bit Score: 51.09  E-value: 6.92e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 318 VQLHAPPRV--------LQVVVSNLVRNACSYTDEgRIDVQVLND----RVVVRDTGIGMSAEALSRAFEPFYRAEPSRP 385
Cdd:cd16954   21 ISLDISPELrfpgerndLMELLGNLLDNACKWCLE-FVEVTARQTdgglHLIVDDDGPGVPESQRSKIFQRGQRLDEQRP 99
                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 503802029 386 qGTGLGLSIVRRLCDRFGWKVSLASEPGKGTEATVIF 422
Cdd:cd16954  100 -GQGLGLAIAKEIVEQYGGELSLSDSPLGGARFEVVF 135
HATPase_DpiB-CitA-like cd16915
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
327-420 1.19e-07

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.


Pssm-ID: 340392 [Multi-domain]  Cd Length: 104  Bit Score: 49.59  E-value: 1.19e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 327 LQVVVSNLVRNA---------------CSYTDEGRIDVqvlndrVVVRDTGIGMSAEALSRAFEPFYRAEPSRpqGTGLG 391
Cdd:cd16915    1 LITIVGNLIDNAldalaatgapnkqveVFLRDEGDDLV------IEVRDTGPGIAPELRDKVFERGVSTKGQG--ERGIG 72
                         90       100
                 ....*....|....*....|....*....
gi 503802029 392 LSIVRRLCDRFGWKVSLASEPGKGTEATV 420
Cdd:cd16915   73 LALVRQSVERLGGSITVESEPGGGTTFSI 101
PRK13557 PRK13557
histidine kinase; Provisional
356-422 1.64e-07

histidine kinase; Provisional


Pssm-ID: 237425 [Multi-domain]  Cd Length: 540  Bit Score: 53.52  E-value: 1.64e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 503802029 356 VVVRDTGIGMSAEALSRAFEPFYRAEpSRPQGTGLGLSIVRRLCDRFGWKVSLASEPGKGTEATVIF 422
Cdd:PRK13557 327 IAVTDTGSGMPPEILARVMDPFFTTK-EEGKGTGLGLSMVYGFAKQSGGAVRIYSEVGEGTTVRLYF 392
HATPase_BvrS-ChvG-like cd16953
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
330-403 2.01e-07

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.


Pssm-ID: 340429 [Multi-domain]  Cd Length: 110  Bit Score: 49.11  E-value: 2.01e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 330 VVSNLVRNACSYT--DEGRIDVQVLND----RVVVRDTGIGMSAEALSRAFEPFYRAEPSRP---QGTGLGLSIVRRLCD 400
Cdd:cd16953    4 VLRNLIGNAISFSppDTGRITVSAMPTgkmvTISVEDEGPGIPQEKLESIFDRFYTERPANEafgQHSGLGLSISRQIIE 83

                 ...
gi 503802029 401 RFG 403
Cdd:cd16953   84 AHG 86
PRK11086 PRK11086
sensory histidine kinase DcuS; Provisional
326-420 4.66e-06

sensory histidine kinase DcuS; Provisional


Pssm-ID: 236839 [Multi-domain]  Cd Length: 542  Bit Score: 48.76  E-value: 4.66e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 326 VLQVVVSNLVRN---ACSYTDEGRIDVQV--LNDRV--VVRDTGIGMSAEALSRAFEPFYRaepSRPQGTGLGLSIVRRL 398
Cdd:PRK11086 433 ELITILGNLIENaleAVGGEEGGEISVSLhyRNGWLhcEVSDDGPGIAPDEIDAIFDKGYS---TKGSNRGVGLYLVKQS 509
                         90       100
                 ....*....|....*....|..
gi 503802029 399 CDRFGWKVSLASEPGKGTEATV 420
Cdd:PRK11086 510 VENLGGSIAVESEPGVGTQFFV 531
marine_sort_HK TIGR03785
proteobacterial dedicated sortase system histidine kinase; This histidine kinase protein is ...
119-400 8.41e-06

proteobacterial dedicated sortase system histidine kinase; This histidine kinase protein is paired with an adjacent response regulator (TIGR03787) gene. It co-occurs with a variant sortase enzyme (TIGR03784), usually in the same gene neighborhood, in proteobacterial species most of which are marine, and with an LPXTG motif-containing sortase target conserved protein (TIGR03788). Sortases and LPXTG proteins are far more common in Gram-positive bacteria, where sortase systems mediate attachment to the cell wall or cross-linking of pilin structures. We give this predicted sensor histidine kinase the gene symbol psdS, for Proteobacterial Dedicated Sortase system Sensor histidine kinase.


Pssm-ID: 163497 [Multi-domain]  Cd Length: 703  Bit Score: 48.20  E-value: 8.41e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029  119 LRSRAEMLAFWFGIVPVLLTLLAVYG-ASWVTYRAskrlvspvnwlaRRVSRwdpgHPEAADLEPNKLPADMQG-----E 192
Cdd:TIGR03785 400 LRNSALEKLFNVILAIMSIGTLALFGfASWISWRI------------RRLSD----DAEAAIDSQGRISGAIPAsrsrdE 463
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029  193 TRQLAAALHSLANRVSAHVARERNFTRDASHELRTPLTVIRVASD----MALGDETLQ---------PRLRRSLQRIQRA 259
Cdd:TIGR03785 464 IGDLSRSFAQMVARLRQYTHYLENMSSRLSHELRTPVAVVRSSLEnlelQALEQEKQKyleraregtERLSMILNNMSEA 543
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029  260 GRDMEAVIDaflilareADVEPqielFDVNDIVRYEVDNANELLGNRPVSVHLhSEGPVQLHAPPRVLQVVVSNLVRNAC 339
Cdd:TIGR03785 544 TRLEQAIQS--------AEVED----FDLSEVLSGCMQGYQMTYPPQRFELNI-PETPLVMRGSPELIAQMLDKLVDNAR 610
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 503802029  340 SYT-DEGRIDVQV-LNDR---VVVRDTGIGMSAEALSRAFEPFYRAEPSRPQGT---GLGLSIVRRLCD 400
Cdd:TIGR03785 611 EFSpEDGLIEVGLsQNKShalLTVSNEGPPLPEDMGEQLFDSMVSVRDQGAQDQphlGLGLYIVRLIAD 679
HATPase_RsbT-like cd16934
Histidine kinase-like ATPase domain of the anti sigma-B factor Bacillus subtilis serine ...
327-422 9.21e-06

Histidine kinase-like ATPase domain of the anti sigma-B factor Bacillus subtilis serine/threonine-protein kinase RsbT, and related domains; This family includes the histidine kinase-like ATPase (HATPase) domain of Bacillus subtilis serine/threonine-protein kinase RsbT, a component of the stressosome signaling complex of Bacillus subtilis. The stressosome is formed from multiple copies of three proteins, a sensor protein RsbR, a scaffold protein RsbS, and RsbT, and responds to environmental changes by initiating a protein partner switching cascade. Stress perception increases the phosphorylation of RsbR and RsbS, by RsbT. Subsequent dissociation of RsbT from the stressosome activates the sigma-B cascade, leading to the release of the alternative sigma factor, sigma-B.


Pssm-ID: 340411 [Multi-domain]  Cd Length: 117  Bit Score: 44.67  E-value: 9.21e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 327 LQVVVSNLVRNACSYTDEGRIDVQVLND------RVVVRDTGIGMS--AEALSRAFepfyraepSRPQGTGLGLSIVRRL 398
Cdd:cd16934   26 IATAVTELARNLLKHAGGGQVLLEVVAEggrvalEILAVDQGPGIAdvDEALRDGF--------STGGGLGLGLGGVRRL 97
                         90       100
                 ....*....|....*....|....
gi 503802029 399 CDRFgwkvSLASEPGKGTEATVIF 422
Cdd:cd16934   98 ADEF----DLHSAPGRGTVVVARK 117
COG3920 COG3920
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ...
9-422 1.04e-05

Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];


Pssm-ID: 443125 [Multi-domain]  Cd Length: 495  Bit Score: 47.59  E-value: 1.04e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029   9 IRIAFILQAVLASLGILLGAWLVSLVIKHSLVGAALREEAAYYWTLHEASPVQPPPNTQNIRGYLLESGQSALSLPANLR 88
Cdd:COG3920   58 LSAAALAAALAVALAAAVGAAAALLALLVLLLLLLLAAAALALALLLAALAGLLLLAALLLLRLVALLAALALLALLLLL 137
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029  89 NLEPGFHELPKDDQLVLVDVRPAGRLYLVFLRSRAEMLAFWFGIVPVLLTLLAVYGASWVTYRASKRLVSPVNWLARRVS 168
Cdd:COG3920  138 LLLLAILALAELAVALAELAAALLLLAEELAALRLAAAALLLLLAALLDLGLALAALAAAALLALLLALELLLALLLLLL 217
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 169 RWDPGHPEAADLEPNKLPADMQGETRQLAAALHSLANRVSAHVARERNFTRDASHELRTPLTVIRVASDMALGDETLQPR 248
Cdd:COG3920  218 LLLALLLVLLAALLRLRAAVLEELERRRRARGLGRLLLLLLLLLLLLRALLLLAAGIRLVITERKRAEEELEASLEEKEL 297
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 249 LRR--------------SLQRIQRAGRDMEAVIDAFL--------------ILAREADVEPqielFDVNDIVRYEVDNAN 300
Cdd:COG3920  298 LLRelhhrvknnlqvvsSLLRLQARRADDPEAREALEesqnriqalalvheLLYQSEDWEG----VDLRDYLRELLEPLR 373
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 301 ELLGNRPVSVHLHSEgPVQLhaPPRVLQ---VVVSNLVRNACSY----TDEGRIDVQVLND----RVVVRDTGIGMSAEA 369
Cdd:COG3920  374 DSYGGRGIRIELDGP-DVEL--PADAAVplgLILNELVTNALKHaflsGEGGRIRVSWRREdgrlRLTVSDNGVGLPEDV 450
                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|...
gi 503802029 370 lsrafepfyraepSRPQGTGLGLSIVRRLCDRFGWKVSLasEPGKGTEATVIF 422
Cdd:COG3920  451 -------------DPPARKGLGLRLIRALVRQLGGTLEL--DRPEGTRVRITF 488
HATPase_LytS-like cd16957
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
323-419 2.10e-05

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis LytS and Staphylococcus aureus LytS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), and a GAF sensor domain; most contain a DUF3816 domain.


Pssm-ID: 340433 [Multi-domain]  Cd Length: 106  Bit Score: 43.18  E-value: 2.10e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 323 PPRVLQVVVSNLVRNACSYTDEG-RIDVQVLND----RVVVRDTGIGMSAEALSRAFEPFYRAEpsrpQGTGLGL-SIVR 396
Cdd:cd16957    2 PPFALQVLVENAIRHAFPKRKENnEVRVVVKKDqhkvHVSVSDNGQGIPEERLDLLGKTTVTSE----KGTGTALeNLNR 77
                         90       100
                 ....*....|....*....|....*
gi 503802029 397 RLCDRFGWKVSL--ASEPGKGTEAT 419
Cdd:cd16957   78 RLIGLFGSEACLhiESEVHGGTEVW 102
glnL PRK11073
nitrogen regulation protein NR(II);
186-420 3.89e-05

nitrogen regulation protein NR(II);


Pssm-ID: 182947 [Multi-domain]  Cd Length: 348  Bit Score: 45.46  E-value: 3.89e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 186 PADMQgetRQLAAALHSLANRVSAhvareRNFTRDASHELRTPLTVIRVASDM---ALGDETLQP----------RLRRS 252
Cdd:PRK11073 110 PMDNQ---RRLSQEQLQHAQQVAA-----RDLVRGLAHEIKNPLGGLRGAAQLlskALPDPALTEytkviieqadRLRNL 181
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 253 LQRI---QRAGRDMEAVIDAflILAReadVEPQIELfDVNDIVRYEVDNANELlgnrpvsvhlhsegPVQLHAPPRVLQV 329
Cdd:PRK11073 182 VDRLlgpQRPGTHVTESIHK--VAER---VVQLVSL-ELPDNVRLIRDYDPSL--------------PELAHDPDQIEQV 241
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 330 VVsNLVRNACSYTDEG--------RIDVQV--------LNDRVVVRDTGIGMSAEALSRAFEPFYRAepsRPQGTGLGLS 393
Cdd:PRK11073 242 LL-NIVRNALQALGPEggtitlrtRTAFQLtlhgeryrLAARIDIEDNGPGIPPHLQDTLFYPMVSG---REGGTGLGLS 317
                        250       260
                 ....*....|....*....|....*..
gi 503802029 394 IVRRLCDRFGWKVSLASEPGKgTEATV 420
Cdd:PRK11073 318 IARNLIDQHSGKIEFTSWPGH-TEFSV 343
ComP COG4585
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
192-422 4.66e-05

Signal transduction histidine kinase ComP [Signal transduction mechanisms];


Pssm-ID: 443642 [Multi-domain]  Cd Length: 252  Bit Score: 44.61  E-value: 4.66e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 192 ETRQLAAALHSLANRVSAHVARERN-FTRD----ASHELrtplTVIRVASDMALGDETLQP-RLRRSLQRIQRAGRDMEA 265
Cdd:COG4585   31 RAERAAELERELAARAEEAREEERRrIARElhdgVGQSL----SAIKLQLEAARRLLDADPeAAREELEEIRELAREALA 106
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 266 VIDAFLILAREADVEPqielFDVNDIVRYEVDNANELLGnrpVSVHLHSEGPVQLHAPPRVLQV--VVSNLVRNACSYTD 343
Cdd:COG4585  107 ELRRLVRGLRPPALDD----LGLAAALEELAERLLRAAG---IRVELDVDGDPDRLPPEVELALyrIVQEALTNALKHAG 179
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 344 EGRIDVQVLND----RVVVRDTGIGMsaealsrafepfyraEPSRPQGTGLGLSIVRRLCDRFGWKVSLASEPGKGTEAT 419
Cdd:COG4585  180 ATRVTVTLEVDdgelTLTVRDDGVGF---------------DPEAAPGGGLGLRGMRERAEALGGTLTIGSAPGGGTRVR 244

                 ...
gi 503802029 420 VIF 422
Cdd:COG4585  245 ATL 247
HATPase_RsbW-like cd16936
Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase ...
327-404 4.21e-04

Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains; This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B.


Pssm-ID: 340413 [Multi-domain]  Cd Length: 91  Bit Score: 39.17  E-value: 4.21e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 327 LQVVVSNLVRNACSYTD----EGRIDVQVLND----RVVVRDTGIGMsaeALSRAFEPfyraEPSRPQGtGLGLSIVRRL 398
Cdd:cd16936    1 VELAVSEAVTNAVRHAYrhdgPGPVRLELDLDpdrlRVEVTDSGPGF---DPLRPADP----DAGLREG-GRGLALIRAL 72

                 ....*.
gi 503802029 399 CDRFGW 404
Cdd:cd16936   73 MDEVGY 78
HATPase_UhpB-NarQ-NarX-like cd16917
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
325-420 1.04e-03

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains.


Pssm-ID: 340394 [Multi-domain]  Cd Length: 87  Bit Score: 37.92  E-value: 1.04e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 325 RVLQVVVSNLVRNAcsYTDEGRIDVQVLNDRVV--VRDTGIGmsaealsrafepfyRAEPSRPQGTGLGLSIVRRLCDRF 402
Cdd:cd16917    3 RIVQEALTNALKHA--GASRVRVTLSYTADELTltVVDDGVG--------------FDGPAPPGGGGFGLLGMRERAELL 66
                         90
                 ....*....|....*...
gi 503802029 403 GWKVSLASEPGKGTEATV 420
Cdd:cd16917   67 GGTLTIGSRPGGGTRVTA 84
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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