|
Name |
Accession |
Description |
Interval |
E-value |
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
105-422 |
1.85e-59 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 196.67 E-value: 1.85e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 105 LVDVRPAGRLYLVFLRSRAEMLAFWFGIVPVLLTLLAVYGASWVTYRASKRLVSPVNWLARRVSRWDPGHPEAADLEPNK 184
Cdd:COG0642 1 LLLLLLLLVLLLLLLLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 185 LPADMQGETRQLAAALHSLANRVSAHVARERNFTRDASHELRTPLTVIRVASDMALgdETLQPRLRRSLQRIQRAGRDME 264
Cdd:COG0642 81 LLLLLLLLLLLLLLLLLALLLLLEEANEAKSRFLANVSHELRTPLTAIRGYLELLL--EELDEEQREYLETILRSADRLL 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 265 AVIDAFLILAR--EADVEPQIELFDVNDIVRYEVDNANELLGNRPVSVHLH-SEGPVQLHAPPRVLQVVVSNLVRNACSY 341
Cdd:COG0642 159 RLINDLLDLSRleAGKLELEPEPVDLAELLEEVVELFRPLAEEKGIELELDlPDDLPTVRGDPDRLRQVLLNLLSNAIKY 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 342 TDEG---RIDVQVLNDRVV--VRDTGIGMSAEALSRAFEPFYRAEPSRP-QGTGLGLSIVRRLCDRFGWKVSLASEPGKG 415
Cdd:COG0642 239 TPEGgtvTVSVRREGDRVRisVEDTGPGIPPEDLERIFEPFFRTDPSRRgGGTGLGLAIVKRIVELHGGTIEVESEPGKG 318
|
....*..
gi 503802029 416 TEATVIF 422
Cdd:COG0642 319 TTFTVTL 325
|
|
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
100-422 |
3.41e-54 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 184.76 E-value: 3.41e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 100 DDQLVLVDVRPAGRLYLVFLRSRAEMLAFWFGIVPVLLTLLAVYGASWVTYRASKRLVSPVNWLARRVSRWDPGHPEAAD 179
Cdd:COG5002 51 LLALLLLLLLLLLLLLALLLLLLLLLLLLALALLLLALLLLLLLLLLLLALLILLLLLALLILLAALLLLLSELLLLLLL 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 180 LEPNKLPADMQGETRQLAAALHSLANRVSAHVARERNFTRDASHELRTPLTVIRVASDMAL-GDETLQPRLRRSLQRIQR 258
Cdd:COG5002 131 LGRLSLRLSALLLGLLLLAAVERDITELERLEQMRREFVANVSHELRTPLTSIRGYLELLLdGAADDPEERREYLEIILE 210
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 259 AGRDMEAVIDAFLILAR--EADVEPQIELFDVNDIVRYEVDNANELLGNRPVSVHLH-SEGPVQLHAPPRVLQVVVSNLV 335
Cdd:COG5002 211 EAERLSRLVNDLLDLSRleSGELKLEKEPVDLAELLEEVVEELRPLAEEKGIELELDlPEDPLLVLGDPDRLEQVLTNLL 290
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 336 RNACSYTDEG---RIDVQVLNDRVV--VRDTGIGMSAEALSRAFEPFYRAEPSR---PQGTGLGLSIVRRLCDRFGWKVS 407
Cdd:COG5002 291 DNAIKYTPEGgtiTVSLREEDDQVRisVRDTGIGIPEEDLPRIFERFYRVDKSRsreTGGTGLGLAIVKHIVEAHGGRIW 370
|
330
....*....|....*
gi 503802029 408 LASEPGKGTEATVIF 422
Cdd:COG5002 371 VESEPGKGTTFTITL 385
|
|
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
215-422 |
1.36e-53 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 178.56 E-value: 1.36e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 215 RNFTRDASHELRTPLTVIRVASDMALGDETLQP-RLRRSLQRIQRAGRDMEAVIDAFLILAR--EADVEPQIELFDVNDI 291
Cdd:COG2205 17 SEFLANVSHELRTPLTSILGAAELLLDEEDLSPeERRELLEIIRESAERLLRLIEDLLDLSRleSGKLSLELEPVDLAEL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 292 VRYEVDNANELLGNRPVSVHLH-SEGPVQLHAPPRVLQVVVSNLVRNACSYTDEG---RIDVQVLNDRVV--VRDTGIGM 365
Cdd:COG2205 97 LEEAVEELRPLAEEKGIRLELDlPPELPLVYADPELLEQVLANLLDNAIKYSPPGgtiTISARREGDGVRisVSDNGPGI 176
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 503802029 366 SAEALSRAFEPFYRAEPSR-PQGTGLGLSIVRRLCDRFGWKVSLASEPGKGTEATVIF 422
Cdd:COG2205 177 PEEELERIFERFYRGDNSRgEGGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTL 234
|
|
| phoR_proteo |
TIGR02966 |
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory ... |
215-422 |
2.74e-40 |
|
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory histidine kinase PhoR associated with the phosphate ABC transporter in most Proteobacteria. Related proteins from Gram-positive organisms are not included in this model. The phoR gene usually is adjacent to the response regulator phoB gene (TIGR02154). [Signal transduction, Two-component systems]
Pssm-ID: 274368 [Multi-domain] Cd Length: 333 Bit Score: 146.20 E-value: 2.74e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 215 RNFTRDASHELRTPLTVIR-VASDMALGDETLQPRLRRSLQRIQRAGRDMEAVIDAFLILAR--EADVEPQIELFDVNDI 291
Cdd:TIGR02966 115 RDFVANVSHELRTPLTVLRgYLETLADGPDEDPEEWNRALEIMLEQSQRMQSLVEDLLTLSRleSAASPLEDEPVDMPAL 194
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 292 VRYEVDNANELLGNRPVSVHLHSEGPVQLHAPPRVLQVVVSNLVRNACSYT-DEGRIDVQVLND----RVVVRDTGIGMS 366
Cdd:TIGR02966 195 LDHLRDEAEALSQGKNHQITFEIDGGVDVLGDEDELRSAFSNLVSNAIKYTpEGGTITVRWRRDgggaEFSVTDTGIGIA 274
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 503802029 367 AEALSRAFEPFYRAEPSRPQ---GTGLGLSIVRRLCDRFGWKVSLASEPGKGTEATVIF 422
Cdd:TIGR02966 275 PEHLPRLTERFYRVDKSRSRdtgGTGLGLAIVKHVLSRHHARLEIESELGKGSTFSFIF 333
|
|
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
222-422 |
1.41e-36 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 138.56 E-value: 1.41e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 222 SHELRTPLTVI-----RVASDMALGDETLQPRLRRSLQRIQRAGRDMEAVIDAFLILAREAdvEPQIELFDVNDIVRYEV 296
Cdd:COG5000 209 AHEIKNPLTPIqlsaeRLRRKLADKLEEDREDLERALDTIIRQVDRLKRIVDEFLDFARLP--EPQLEPVDLNELLREVL 286
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 297 DNANELLGNRPVSVHLH-SEGPVQLHAPPRVLQVVVSNLVRNAC-SYTDEGRIDVQV--LNDRVV--VRDTGIGMSAEAL 370
Cdd:COG5000 287 ALYEPALKEKDIRLELDlDPDLPEVLADRDQLEQVLINLLKNAIeAIEEGGEIEVSTrrEDGRVRieVSDNGPGIPEEVL 366
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 503802029 371 SRAFEPFYRaepSRPQGTGLGLSIVRRLCDRFGWKVSLASEPGKGTEATVIF 422
Cdd:COG5000 367 ERIFEPFFT---TKPKGTGLGLAIVKKIVEEHGGTIELESRPGGGTTFTIRL 415
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
223-422 |
4.06e-35 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 133.00 E-value: 4.06e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 223 HELRTPLTVIRVASDMA---LGDETLQPRLRRSLQRIQRAGRDMEAVIDAFLILAREAdvEPQIELFDVNDIVRYEVDNA 299
Cdd:COG4191 151 HEINNPLAAILGNAELLrrrLEDEPDPEELREALERILEGAERAAEIVRSLRAFSRRD--EEEREPVDLNELIDEALELL 228
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 300 NELLGNRPVSVHLH-SEGPVQLHAPPRVLQVVVSNLVRNAC---SYTDEGRIDVQVLND----RVVVRDTGIGMSAEALS 371
Cdd:COG4191 229 RPRLKARGIEVELDlPPDLPPVLGDPGQLEQVLLNLLINAIdamEEGEGGRITISTRREgdyvVISVRDNGPGIPPEVLE 308
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 503802029 372 RAFEPFY--RAEPsrpQGTGLGLSIVRRLCDRFGWKVSLASEPGKGTEATVIF 422
Cdd:COG4191 309 RIFEPFFttKPVG---KGTGLGLSISYGIVEKHGGRIEVESEPGGGTTFTITL 358
|
|
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
5-422 |
5.61e-34 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 132.60 E-value: 5.61e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 5 LPRKIRIAFILQAVLASLGILLGAWLVSLVIKHSLVGAALREEAAYYWTLHEASPVQPPPNTQNIRGYLLESGQSALSLP 84
Cdd:COG4251 84 LLLLELALVLLALLLVLLLLLALLLLLALLLLLELLLLLLALLLLLLLLALLLLEELALLRLALALLLLLLLLLLLLLLL 163
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 85 ANLRNLEPGFHELPKDDQLVLVDVRPAGRLYLVFLRSRAEMLAFWFGIVPVLLTLLAVYGASWVTYRASKRLVSPVNWLA 164
Cdd:COG4251 164 LALILALLLAALAELELLLLLLLVLLLLLLLLLLLLLLLLRLLLELLLLLEAELLLSLGGGLGLLLLLLLLLVLLLLLIL 243
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 165 RRVSRWDPGHPEAADLEPNKLPADMQGETRQLAAALHSLanrvsahvareRNFTRDASHELRTPLTVIRVASDMALGD-- 242
Cdd:COG4251 244 LLLLLILVLELLELRLELEELEEELEERTAELERSNEEL-----------EQFAYVASHDLREPLRKISGFSQLLEEDyg 312
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 243 ETLQPRLRRSLQRIQRAGRDMEAVIDAFLILAREADVEPQIELFDVNDIVRYEVDNANELLGNRPVSVHlHSEGPVqLHA 322
Cdd:COG4251 313 DKLDEEGREYLERIRDAAERMQALIDDLLAYSRVGRQELEFEPVDLNELLEEVLEDLEPRIEERGAEIE-VGPLPT-VRG 390
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 323 PPRVLQVVVSNLVRNACSYTDEG-----RIDVQVLNDRVV--VRDTGIGMSAEALSRAFEPFYRAEP-SRPQGTGLGLSI 394
Cdd:COG4251 391 DPTLLRQVFQNLISNAIKYSRPGeppriEIGAEREGGEWVfsVRDNGIGIDPEYAEKIFEIFQRLHSrDEYEGTGIGLAI 470
|
410 420
....*....|....*....|....*...
gi 503802029 395 VRRLCDRFGWKVSLASEPGKGteATVIF 422
Cdd:COG4251 471 VKKIVERHGGRIWVESEPGEG--ATFYF 496
|
|
| PRK10337 |
PRK10337 |
sensor protein QseC; Provisional |
129-420 |
2.63e-33 |
|
sensor protein QseC; Provisional
Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 129.77 E-value: 2.63e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 129 WFGIVPVLLTLLAVygaswvtyrASKRLVSPVNWLARRVSRWDPghPEAADLEPNKLPAdmqgETRQLAAALHSLANRVS 208
Cdd:PRK10337 167 WLVALPIMLIILMV---------LLGRELAPLKKLALALRMRDP--DSETPLNATGVPS----EVRPLVEALNQLFARTH 231
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 209 AHVARERNFTRDASHELRTPLTVIRVASDMA-LGDETLQPRlRRSLQR----IQRAGRdmeaVIDAFLILAR---EADVE 280
Cdd:PRK10337 232 AMMVRERRFTSDAAHELRSPLAALKVQTEVAqLSDDDPQAR-KKALLQlhagIDRATR----LVDQLLTLSRldsLDNLQ 306
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 281 pQIELFDVNDIVRYEVDNANELLGNRPVSVHLHSEG-PVQLHAPPRVLQVVVSNLVRNACSYTDEG-RIDVQVLNDRVVV 358
Cdd:PRK10337 307 -DVAEIPLEDLLQSAVMDIYHTAQQAGIDVRLTLNAhPVIRTGQPLLLSLLVRNLLDNAIRYSPQGsVVDVTLNARNFTV 385
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 503802029 359 RDTGIGMSAEALSRAFEPFYRAEPSRPQGTGLGLSIVRRLCDRFGWKVSLASEPGKGTEATV 420
Cdd:PRK10337 386 RDNGPGVTPEALARIGERFYRPPGQEATGSGLGLSIVRRIAKLHGMNVSFGNAPEGGFEAKV 447
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
324-423 |
3.88e-29 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 109.66 E-value: 3.88e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 324 PRVLQVVVSNLVRNACSYTDE-GRIDVQVLND----RVVVRDTGIGMSAEALSRAFEPFYRAEPSRPQ--GTGLGLSIVR 396
Cdd:smart00387 3 PDRLRQVLSNLLDNAIKYTPEgGRITVTLERDgdhvEITVEDNGPGIPPEDLEKIFEPFFRTDKRSRKigGTGLGLSIVK 82
|
90 100
....*....|....*....|....*..
gi 503802029 397 RLCDRFGWKVSLASEPGKGTEATVIFR 423
Cdd:smart00387 83 KLVELHGGEISVESEPGGGTTFTITLP 109
|
|
| MtrAB_MtrB |
NF040691 |
MtrAB system histidine kinase MtrB; |
114-417 |
9.79e-29 |
|
MtrAB system histidine kinase MtrB;
Pssm-ID: 468655 [Multi-domain] Cd Length: 507 Bit Score: 117.82 E-value: 9.79e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 114 LYLVF-LRSRAEMLAF---WFGIVPVLLTLLAVYGASWVTyrasKRLVSPVNWLARRVSRWDPGHPEAadlepnKLPADM 189
Cdd:NF040691 170 LYLLFpLEDEQSTLALvrgTLLLGGLALVVLLGLIAWLVT----RQVVAPVRSAARTAERFAAGDLSE------RMPVKG 239
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 190 QGETRQLAAALHSLANRVSAHVAR-------ERNFTRDASHELRTPLTVIRVASD-MALGDETLQPRLRRSLQRIQRAGR 261
Cdd:NF040691 240 EDDLARLARSFNQMADSLQRQIRQleelsrlQQRFVSDVSHELRTPLTTIRMAADvIHDSRDDFDPATARSAELLHTELD 319
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 262 DMEAVIDAFLILAR--EADVEPQIELFDVNDIVRYEVDNANELLGNRPVSVHLHS-EGPVQLHAPPRVLQVVVSNLVRNA 338
Cdd:NF040691 320 RFESLLSDLLEISRfdAGAAELDVEPVDLRPLVRRVVDALRQLAERAGVELRVDApGTPVVAEVDPRRVERVLRNLVVNA 399
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 339 CSYTDEGRIDVQVLNDR----VVVRDTGIGMSAEALSRAFEPFYRAEPSRPQ---GTGLGLSIVR---RLcdRFGWkVSL 408
Cdd:NF040691 400 IEHGEGKPVVVTVAQDDtavaVTVRDHGVGLKPGEVALVFDRFWRADPARARttgGTGLGLAIALedaRL--HGGW-LEA 476
|
....*....
gi 503802029 409 ASEPGKGTE 417
Cdd:NF040691 477 WGRPGQGSQ 485
|
|
| KinB |
COG5806 |
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome ... |
222-422 |
7.17e-27 |
|
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444508 [Multi-domain] Cd Length: 412 Bit Score: 111.11 E-value: 7.17e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 222 SHELRTPLTVIRVASDMALGDETLQPRLRR----SLQRIQRAgrdmEAVIDAFLILAREAdvEPQIELFDVNDIVRYEVD 297
Cdd:COG5806 209 AHEVRNPLTVVRGFIQLLQEPELSDEKRKQyiriALEELDRA----EAIITDYLTFAKPQ--PEKLEKIDVSEELEHVID 282
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 298 NANELLGNRPVSVHLHSEGPVQLHAPPRVLQVVVSNLVRNAC-SYTDEGRIDVQVLNDR----VVVRDTGIGMSAEALSR 372
Cdd:COG5806 283 VLSPYANMNNVEIQTELEPGLYIEGDRQKLQQCLINIIKNGIeAMPNGGTLTIDVSIDKnkviISIKDTGVGMTKEQLER 362
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 503802029 373 AFEPFYRaepSRPQGTGLGLSIVRRLCDRFGWKVSLASEPGKGTEATVIF 422
Cdd:COG5806 363 LGEPYFS---TKEKGTGLGTMVSYRIIEAMNGTIRVESEVGKGTTFTITL 409
|
|
| cztS_silS_copS |
TIGR01386 |
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ... |
135-414 |
1.62e-26 |
|
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.
Pssm-ID: 273593 [Multi-domain] Cd Length: 457 Bit Score: 110.94 E-value: 1.62e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 135 VLLTLLAVYGASWVTYRASKRLVSPVNWLARRVSRWDPgHPEAADLEPNKLPAdmqgETRQLAAALHSLANRVSAHVARE 214
Cdd:TIGR01386 167 ILIAVLLVLLTALLGWWITRLGLEPLRRLSAVAARISP-ESLDQRLDPSRAPA----ELRELAQSFNAMLGRLEDAFQRL 241
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 215 RNFTRDASHELRTPLTVIRVASDMALGDETLQPRLRRSLQRIQRAGRDMEAVIDAFLILAR--EADVEPQIELFDVNDIV 292
Cdd:TIGR01386 242 SQFSADLAHELRTPLTNLLGQTQVALSQPRTGEEYREVLESNLEELERLSRMVSDMLFLARadNGQLALERVRLDLAAEL 321
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 293 RYEVDNANELLGNRPVSVHLhsEGPVQLHAPPRVLQVVVSNLVRNACSYT-DEGRIDVQVLND----RVVVRDTGIGMSA 367
Cdd:TIGR01386 322 AKVAEYFEPLAEERGVRIRV--EGEGLVRGDPQMFRRAISNLLSNALRHTpDGGTITVRIERRsdevRVSVSNPGPGIPP 399
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 503802029 368 EALSRAFEPFYRAEPSR---PQGTGLGLSIVRRLCDRFGWKVSLASEPGK 414
Cdd:TIGR01386 400 EHLSRLFDRFYRVDPARsnsGEGTGLGLAIVRSIMEAHGGRASAESPDGK 449
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
324-423 |
2.71e-26 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 102.06 E-value: 2.71e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 324 PRVLQVVVSNLVRNACSYT-DEGRIDVQVLND---RVVVRDTGIGMSAEALSRAFEPFYRAEPSRPQGTGLGLSIVRRLC 399
Cdd:pfam02518 3 ELRLRQVLSNLLDNALKHAaKAGEITVTLSEGgelTLTVEDNGIGIPPEDLPRIFEPFSTADKRGGGGTGLGLSIVRKLV 82
|
90 100
....*....|....*....|....
gi 503802029 400 DRFGWKVSLASEPGKGTEATVIFR 423
Cdd:pfam02518 83 ELLGGTITVESEPGGGTTVTLTLP 106
|
|
| HATPase_EvgS-ArcB-TorS-like |
cd16922 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ... |
327-421 |
1.21e-25 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 100.26 E-value: 1.21e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 327 LQVVVSNLVRNACSYTDEGRID--VQVLND-------RVVVRDTGIGMSAEALSRAFEPFYRAEPS---RPQGTGLGLSI 394
Cdd:cd16922 1 LRQILLNLLGNAIKFTEEGEVTlrVSLEEEeedgvqlRFSVEDTGIGIPEEQQARLFEPFSQADSSttrKYGGTGLGLAI 80
|
90 100
....*....|....*....|....*..
gi 503802029 395 VRRLCDRFGWKVSLASEPGKGTEATVI 421
Cdd:cd16922 81 SKKLVELMGGDISVESEPGQGSTFTFT 107
|
|
| TMAO_torS |
TIGR02956 |
TMAO reductase sytem sensor TorS; This protein, TorS, is part of a regulatory system for the ... |
193-417 |
8.65e-25 |
|
TMAO reductase sytem sensor TorS; This protein, TorS, is part of a regulatory system for the torCAD operon that encodes the pterin molybdenum cofactor-containing enzyme trimethylamine-N-oxide (TMAO) reductase (TorA), a cognate chaperone (TorD), and a penta-haem cytochrome (TorC). TorS works together with the inducer-binding protein TorT and the response regulator TorR. TorS contains histidine kinase ATPase (pfam02518), HAMP (pfam00672), phosphoacceptor (pfam00512), and phosphotransfer (pfam01627) domains and a response regulator receiver domain (pfam00072). [Signal transduction, Two-component systems]
Pssm-ID: 274362 [Multi-domain] Cd Length: 968 Bit Score: 107.17 E-value: 8.65e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 193 TRQLAAALHSLANRVSAH-----VARERN-----FTRDASHELRTPLTVIrVASDMALGDETLQPRLRRSLQRIQRAGRD 262
Cdd:TIGR02956 433 TQELAETNERLNAEVKNHakaraEAEEANraksaFLATMSHEIRTPLNGI-LGTLELLGDTGLTSQQQQYLQVINRSGES 511
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 263 MEAVIDAFL----ILAREADVEPqiELFDVNDIvryeVDNANELLGNR--PVSVHLHSEGPVQLHA-----PPRVLQVVV 331
Cdd:TIGR02956 512 LLDILNDILdyskIEAGHLSISP--RPFDLNAL----LDDVHHLMVSRaqLKGIQLRLNIPEQLPNwwqgdGPRIRQVLI 585
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 332 sNLVRNACSYTDEGRIDVQV-LND----RVVVRDTGIGMSAEALSRAFEPFYRAEPSRPQ-GTGLGLSIVRRLCDRFGWK 405
Cdd:TIGR02956 586 -NLVGNAIKFTDRGSVVLRVsLNDdsslLFEVEDTGCGIAEEEQATLFDAFTQADGRRRSgGTGLGLAISQRLVEAMDGE 664
|
250
....*....|..
gi 503802029 406 VSLASEPGKGTE 417
Cdd:TIGR02956 665 LGVESELGVGSC 676
|
|
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
223-422 |
1.09e-24 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 104.16 E-value: 1.09e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 223 HELRTPLTVIRVASDMaLGDETLQPRLRRSLQRIQRAGRDMEAVIDAFLILAREAdvEPQIELFDVNDIVRYEVDNANEL 302
Cdd:COG3852 144 HEIRNPLTGIRGAAQL-LERELPDDELREYTQLIIEEADRLNNLVDRLLSFSRPR--PPEREPVNLHEVLERVLELLRAE 220
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 303 LGNRpVSVHLH---SEGPVQLHaPPRVLQVVVsNLVRNAC-SYTDEGRIDVQVLND--------------RVVVRDTGIG 364
Cdd:COG3852 221 APKN-IRIVRDydpSLPEVLGD-PDQLIQVLL-NLVRNAAeAMPEGGTITIRTRVErqvtlgglrprlyvRIEVIDNGPG 297
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 503802029 365 MSAEALSRAFEPFYRaepSRPQGTGLGLSIVRRLCDRFGWKVSLASEPGKGTEATVIF 422
Cdd:COG3852 298 IPEEILDRIFEPFFT---TKEKGTGLGLAIVQKIVEQHGGTIEVESEPGKGTTFRIYL 352
|
|
| envZ |
PRK09467 |
osmolarity sensor protein; Provisional |
222-422 |
1.35e-23 |
|
osmolarity sensor protein; Provisional
Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 101.91 E-value: 1.35e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 222 SHELRTPLTVIRVASDM-ALGDETLQprlrrslQRIQRAGRDMEAVIDAFLILAREaDVEPQIELFDVNDIVRyEVDNAN 300
Cdd:PRK09467 237 SHDLRTPLTRIRLATEMmSEEDGYLA-------ESINKDIEECNAIIEQFIDYLRT-GQEMPMEMADLNALLG-EVIAAE 307
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 301 ellGNRPVSVHLH-SEGPVQLHAPPRVLQVVVSNLVRNACSYTdEGRIDV--QVLNDRVV--VRDTGIGMSAEALSRAFE 375
Cdd:PRK09467 308 ---SGYEREIETAlQPGPIEVPMNPIAIKRALANLVVNAARYG-NGWIKVssGTEGKRAWfqVEDDGPGIPPEQLKHLFQ 383
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 503802029 376 PFYRAEPSR-PQGTGLGLSIVRRLCDRFGWKVSLASEPGKGTEATVIF 422
Cdd:PRK09467 384 PFTRGDSARgSSGTGLGLAIVKRIVDQHNGKVELGNSEEGGLSARAWL 431
|
|
| KinE |
COG5809 |
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ... |
222-422 |
2.67e-22 |
|
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 98.89 E-value: 2.67e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 222 SHELRTPLTVIRVASDMALGDETLQPRL-----RRSLQRIqragrdmEAVIDAFLILAReadvePQ---IELFDVNDIVR 293
Cdd:COG5809 278 AHEIRNPLTSLKGFIQLLKDTIDEEQKTyldimLSELDRI-------ESIISEFLVLAK-----PQaikYEPKDLNTLIE 345
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 294 YEVD--NANELLGNrpVSVHLHSEGPVqlhaPP------RVLQVVVsNLVRNACSYTDEG---RIDVQVLNDRVV---VR 359
Cdd:COG5809 346 EVIPllQPQALLKN--VQIELELEDDI----PDilgdenQLKQVFI-NLLKNAIEAMPEGgniTIETKAEDDDKVvisVT 418
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 503802029 360 DTGIGMSAEALSRAFEPFY-RAEpsrpQGTGLGLSIVRRLCDRFGWKVSLASEPGKGTEATVIF 422
Cdd:COG5809 419 DEGCGIPEERLKKLGEPFYtTKE----KGTGLGLMVSYKIIEEHGGKITVESEVGKGTTFSITL 478
|
|
| phoR |
PRK11006 |
phosphate regulon sensor histidine kinase PhoR; |
212-416 |
1.19e-21 |
|
phosphate regulon sensor histidine kinase PhoR;
Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 96.23 E-value: 1.19e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 212 AReRNFTRDASHELRTPLTVIRVASDMaLGDETLQPRLR-RSLQRIQRAGRDMEAVIDAFLILAR-EAdvEPQIELFDVN 289
Cdd:PRK11006 203 AR-RNFFANVSHELRTPLTVLQGYLEM-MQDQPLEGALReKALHTMREQTQRMEGLVKQLLTLSKiEA--APTIDLNEKV 278
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 290 DI------VRYEVdnanELLGNRPVSVHLHSEGPVQLHAPPRVLQVVVSNLVRNACSYTDEG-RIDVQVLND----RVVV 358
Cdd:PRK11006 279 DVpmmlrvLEREA----QTLSQGKHTITFEVDNSLKVFGNEDQLRSAISNLVYNAVNHTPEGtHITVRWQRVpqgaEFSV 354
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 503802029 359 RDTGIGMSAEALSRAFEPFYRAEPSRPQ---GTGLGLSIVRRLCDRFGWKVSLASEPGKGT 416
Cdd:PRK11006 355 EDNGPGIAPEHIPRLTERFYRVDKARSRqtgGSGLGLAIVKHALSHHDSRLEIESEVGKGT 415
|
|
| PRK10755 |
PRK10755 |
two-component system sensor histidine kinase PmrB; |
131-422 |
1.88e-21 |
|
two-component system sensor histidine kinase PmrB;
Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 94.65 E-value: 1.88e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 131 GIVPVLLTLLavygaswVTYRASKRLVSPVNWLARRVSRwdpghpEAADlepNKLPADMQGETRQLAA---ALHSLANRV 207
Cdd:PRK10755 67 SLVMVSLTLL-------ICFQAVRWITRPLAELQKELEA------RTAD---NLTPIAIHSSTLEIEAvtsALNQLVSRL 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 208 SAHVARERNFTRDASHELRTPLTVIRVasDMALGDETLQPRLRRSLQRIQRagrdMEAVIDAFLILAR--EADVEPQIEL 285
Cdd:PRK10755 131 TSTLDQERLFTADVAHELRTPLAGIRL--HLELLEKQHHIDVAPLIARLDQ----MMHTVEQLLQLARagQSFSSGHYQT 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 286 FD-VNDIVRYEVDNANELLGNRPVSVHL-HSEGPVQLHAPPRVLQVVVSNLVRNACSYTDEG-RIDVQVLND----RVVV 358
Cdd:PRK10755 205 VKlLEDVILPSQDELSEMLEQRQQTLLLpESAADITVQGDATLLRLLLRNLVENAHRYSPEGsTITIKLSQEdggaVLAV 284
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 503802029 359 RDTGIGMSAEALSRAFEPFYRAEpSRPQGTGLGLSIVRRLCDRFGWKVSLASEP-GKGTEATVIF 422
Cdd:PRK10755 285 EDEGPGIDESKCGELSKAFVRMD-SRYGGIGLGLSIVSRITQLHHGQFFLQNRQeRSGTRAWVWL 348
|
|
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
120-422 |
7.57e-21 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 94.14 E-value: 7.57e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 120 RSRAEMLafWFGIVPVLLTLLAVYGASWVTYRASKRLVSPVNWLA--RRVSrwdpghpeaadlepnkLPADMQGETRQLA 197
Cdd:PRK11100 179 RSERRIL--WAGALLLGIALLIGAGVVWWLNRSIRRLTRYADAVTegKPVP----------------LPKLGSSELRELA 240
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 198 AALHSLANRVS--AHVARernFTRDASHELRTPLTVIRVASDMaLGDETLQPRLRRSLQRIQRAGRDMEAVIDAFLILAR 275
Cdd:PRK11100 241 QALESMRVKLEgkAYVEQ---YVQTLTHELKSPLAAIRGAAEL-LQEDPPPEDRARFTGNILTQSARLQQLIDRLLELAR 316
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 276 -EADVEPQ-IELFDVNDIVRYEVDNANELLGNRPVSVHLHSEgPVQLHAPPRVLQVVVSNLVRNACSYTDEG---RIDVQ 350
Cdd:PRK11100 317 lEQRQELEvLEPVALAALLEELVEAREAQAAAKGITLRLRPD-DARVLGDPFLLRQALGNLLDNAIDFSPEGgtiTLSAE 395
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 503802029 351 VLNDRV--VVRDTGIGMSAEALSRAFEPFY---RAEpSRPQGTGLGLSIVRRLCDRFGWKVSLASEPGKGTEATVIF 422
Cdd:PRK11100 396 VDGEQValSVEDQGPGIPDYALPRIFERFYslpRPA-NGRKSTGLGLAFVREVARLHGGEVTLRNRPEGGVLATLTL 471
|
|
| PRK11360 |
PRK11360 |
two-component system sensor histidine kinase AtoS; |
223-422 |
1.50e-20 |
|
two-component system sensor histidine kinase AtoS;
Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 93.88 E-value: 1.50e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 223 HELRTPLTVIRvASDMALGDETLQPRLRRSLQRIQRAGRDMEAVIDAFLILAREAdvEPQIELFDVNDIVRYEVDNANEL 302
Cdd:PRK11360 399 HEIRNPLTAIR-GYVQIWRQQTSDPPSQEYLSVVLREVDRLNKVIDQLLEFSRPR--ESQWQPVSLNALVEEVLQLFQTA 475
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 303 LGNRPVSVHLHSEGPVQL-HAPPRVLQVVVSNLVRNACSYTDEG---RIDVQVLNDR---VVVRDTGIGMSAEALSRAFE 375
Cdd:PRK11360 476 GVQARVDFETELDNELPPiWADPELLKQVLLNILINAVQAISARgkiRIRTWQYSDGqvaVSIEDNGCGIDPELLKKIFD 555
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 503802029 376 PFYraePSRPQGTGLGLSIVRRLCDRFGWKVSLASEPGKGTEATVIF 422
Cdd:PRK11360 556 PFF---TTKAKGTGLGLALSQRIINAHGGDIEVESEPGVGTTFTLYL 599
|
|
| BaeS_SmeS |
NF012163 |
sensor histidine kinase efflux regulator BaeS; |
129-422 |
1.59e-20 |
|
sensor histidine kinase efflux regulator BaeS;
Pssm-ID: 411086 [Multi-domain] Cd Length: 457 Bit Score: 93.35 E-value: 1.59e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 129 WFGIVpVLLTLLAVYgASWVTYRA----SKRLVSPVNWLAR-----RVSRwdpghpeAADLEPNKLPADMQgetrQLAAA 199
Cdd:NF012163 166 SWLIV-ALALLLAAL-AAFLLARGllapVKRLVEATHRLAAgdyttRVTP-------TSNDELGKLAQDFN----QLAST 232
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 200 LHSlanrvsaHVARERNFTRDASHELRTPLTVIRvASDMALGDeTLQPRLRRSLQRIQRAGRDMEAVID--AFLILAREA 277
Cdd:NF012163 233 LEK-------NEQMRRDFMADISHELRTPLAVLR-AELEAIQD-GIRKFTPESLDSLQAEVGTLTKLVDdlHDLSMSDEG 303
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 278 DVEPQIELFDVNDIVRYEVDNANELLGNRPVSVHLHSEGPVQLHAPPRVLQVVVSNLVRNACSYTDE-GRIDVQVLND-- 354
Cdd:NF012163 304 ALAYQKASVDLVPLLEVEGGAFRERFASAGLELEVSLPDSSLVFGDRDRLMQLFNNLLENSLRYTDSgGSLHISASQRpk 383
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 503802029 355 --RVVVRDTGIGMSAEALSRAFEPFYRAEPSR---PQGTGLGLSIVRRLCDRFGWKVSLASEPGKGTEATVIF 422
Cdd:NF012163 384 evTLTVADSAPGVSDEQLARLFERFYRVEVSRnraSGGSGLGLAISLNIVQAHGGTLHAAHSPLGGLRIVVTL 456
|
|
| HATPase_BasS-like |
cd16940 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
314-420 |
2.72e-20 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.
Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 85.54 E-value: 2.72e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 314 SEGPVQLHAPPRVLQVVVSNLVRNACSYTDEG-RIDVQVLNDR---VVVRDTGIGMSAEALSRAFEPFYRAEPSRPQGTG 389
Cdd:cd16940 1 SAADIQVQGDALLLFLLLRNLVDNAVRYSPQGsRVEIKLSADDgavIRVEDNGPGIDEEELEALFERFYRSDGQNYGGSG 80
|
90 100 110
....*....|....*....|....*....|.
gi 503802029 390 LGLSIVRRLCDRFGWKVSLASEPGKGTEATV 420
Cdd:cd16940 81 LGLSIVKRIVELHGGQIFLGNAQGGGLEAWV 111
|
|
| HK_WalK |
NF033092 |
cell wall metabolism sensor histidine kinase WalK; This model describes WalK as found in ... |
215-422 |
5.31e-20 |
|
cell wall metabolism sensor histidine kinase WalK; This model describes WalK as found in Staphylococcus aureus (sp|Q2G2U4.1|WALK_STAA8). A shorter version, as found in Streptococcus pneumoniae, called WalK(Spn) or VicK, is not included. WalK is part of a two-component system and works with partner protein WalR.
Pssm-ID: 467964 [Multi-domain] Cd Length: 594 Bit Score: 92.12 E-value: 5.31e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 215 RNFTRDASHELRTPLTVIR----VASDMALGDETLQPRLrrsLQRIQRAGRDMEAVIDAFLILAR--EADVEPQIELFDV 288
Cdd:NF033092 373 REFVANVSHELRTPLTTMRsyleALADGAWKDPELAPRF---LGVTQNETERMIRLVNDLLQLSRmdSKDYKLNKEWVNF 449
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 289 ND-----IVRYEVDNANE------LLGNRPVSVHLHsegpvqlhaPPRVLQvVVSNLVRNACSYT-DEGRIDVQVL--ND 354
Cdd:NF033092 450 NEffnyiIDRFEMILKNKnitfkrEFPKRDLWVEID---------TDKITQ-VLDNIISNAIKYSpEGGTITFRLLetHN 519
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 503802029 355 RVVVR--DTGIGMSAEALSRAFEPFYRAEP--SRPQ-GTGLGLSIVRRLCDRFGWKVSLASEPGKGTeaTVIF 422
Cdd:NF033092 520 RIIISisDQGLGIPKKDLDKIFDRFYRVDKarSRKMgGTGLGLAIAKEVVEAHGGRIWAESEEGKGT--TIYF 590
|
|
| HATPase_AtoS-like |
cd16943 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
323-421 |
3.84e-19 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.
Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 82.08 E-value: 3.84e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 323 PPRVLQVVVsNLVRNACSYTDE-GRIDVQVLND----RVVVRDTGIGMSAEALSRAFEPFYRAEPSRpQGTGLGLSIVRR 397
Cdd:cd16943 1 PSQLNQVLL-NLLVNAAQAMEGrGRITIRTWAHvdqvLIEVEDTGSGIDPEILGRIFDPFFTTKPVG-EGTGLGLSLSYR 78
|
90 100
....*....|....*....|....
gi 503802029 398 LCDRFGWKVSLASEPGKGTEATVI 421
Cdd:cd16943 79 IIQKHGGTIRVASVPGGGTRFTII 102
|
|
| HATPase_BceS-YxdK-YvcQ-like |
cd16948 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
327-422 |
1.30e-18 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.
Pssm-ID: 340424 [Multi-domain] Cd Length: 109 Bit Score: 80.79 E-value: 1.30e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 327 LQVVVSNLVRNACSYTDEG---RIDVQVLNDRVV--VRDTGIGMSAEALSRAFEPFYRAEPSRPQG--TGLGLSIVRRLC 399
Cdd:cd16948 6 LSFIIGQIVSNALKYSKQGgkiEIYSETNEQGVVlsIKDFGIGIPEEDLPRVFDKGFTGENGRNFQesTGMGLYLVKKLC 85
|
90 100
....*....|....*....|...
gi 503802029 400 DRFGWKVSLASEPGKGTEATVIF 422
Cdd:cd16948 86 DKLGHKIDVESEVGEGTTFTITF 108
|
|
| PRK09835 |
PRK09835 |
Cu(+)/Ag(+) sensor histidine kinase; |
180-412 |
2.85e-18 |
|
Cu(+)/Ag(+) sensor histidine kinase;
Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 86.75 E-value: 2.85e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 180 LEPNKLPAdmqgETRQLAAALHSLANRVSAHVARERNFTRDASHELRTPLTVIRVASDMALGDETLQPRLRRSL------ 253
Cdd:PRK09835 232 LDPQTVPI----ELEQLVLSFNHMIERIEDVFTRQSNFSADIAHEIRTPITNLITQTEIALSQSRSQKELEDVLysnlee 307
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 254 -QRIQRAGRDMeavidAFLILAREADVEPQIELFDVNDIVRYEVDNANELLGNRPVSVHLHSEGPvQLHAPPRVLQVVVS 332
Cdd:PRK09835 308 lTRMAKMVSDM-----LFLAQADNNQLIPEKKMLDLADEVGKVFDFFEAWAEERGVELRFVGDPC-QVAGDPLMLRRAIS 381
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 333 NLVRNACSYTDEG-----RIDVQVLNDRVVVRDTGIGMSAEALSRAFEPFYRAEPSRP---QGTGLGLSIVRRLCDRFGW 404
Cdd:PRK09835 382 NLLSNALRYTPAGeaitvRCQEVDHQVQLVVENPGTPIAPEHLPRLFDRFYRVDPSRQrkgEGSGIGLAIVKSIVVAHKG 461
|
....*...
gi 503802029 405 KVSLASEP 412
Cdd:PRK09835 462 TVAVTSDA 469
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
223-422 |
7.58e-18 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 85.55 E-value: 7.58e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 223 HELRTPLTVIR-VASDMALGDETLQPRLRRSLQRIQRagrdMEAVIDAFLILAReaDVEPQIELFDVNDIVRYEVD--NA 299
Cdd:COG5805 296 HEIRNPLTSIKgFLQLLQPGIEDKEEYFDIMLSELDR----IESIISEFLALAK--PQAVNKEKENINELIQDVVTllET 369
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 300 NELLGNrpVSVHLHSEGPVQ-LHAPPRVLQVVVSNLVRNAC-SYTDEGRIDVQV-LNDRVV---VRDTGIGMSAEALSRA 373
Cdd:COG5805 370 EAILHN--IQIRLELLDEDPfIYCDENQIKQVFINLIKNAIeAMPNGGTITIHTeEEDNSViirVIDEGIGIPEERLKKL 447
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 503802029 374 FEPFYraePSRPQGTGLGLSIVRRLCDRFGWKVSLASEPGKGTEATVIF 422
Cdd:COG5805 448 GEPFF---TTKEKGTGLGLMVSYKIIENHNGTIDIDSKVGKGTTFTITL 493
|
|
| PRK11466 |
PRK11466 |
hybrid sensory histidine kinase TorS; Provisional |
222-416 |
1.87e-17 |
|
hybrid sensory histidine kinase TorS; Provisional
Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 84.96 E-value: 1.87e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 222 SHELRTPLTVIrVASDMALGDETLQPRLRRSLQRIQRAGRDMEAVIDAFL----ILAREADVEPQIELFDVNDIVRYEVD 297
Cdd:PRK11466 452 SHEIRTPLYGI-LGTAQLLADNPALNAQRDDLRAITDSGESLLTILNDILdysaIEAGGKNVSVSDEPFEPRPLLESTLQ 530
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 298 NANELLGNRPVSV-HLHSEG-PVQLHAPPRVLQVVVSNLVRNACSYTDEGRIDVQVLNDR----VVVRDTGIGMSAEALS 371
Cdd:PRK11466 531 LMSGRVKGRPIRLaTDIADDlPTALMGDPRRIRQVITNLLSNALRFTDEGSIVLRSRTDGeqwlVEVEDSGCGIDPAKLA 610
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 503802029 372 RAFEPFYRAEPSRpQGTGLGLSIVRRLCDRFGWKVSLASEPGKGT 416
Cdd:PRK11466 611 EIFQPFVQVSGKR-GGTGLGLTISSRLAQAMGGELSATSTPEVGS 654
|
|
| PRK10549 |
PRK10549 |
two-component system sensor histidine kinase BaeS; |
136-422 |
4.51e-17 |
|
two-component system sensor histidine kinase BaeS;
Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 82.76 E-value: 4.51e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 136 LLTLLAVYgASWVTYRA----SKRLVSPVNWLArrvsrwdpghpeAADLEpNKLPADMQGETRQLAAALHSLANRVSAHV 211
Cdd:PRK10549 172 LSTLLAAL-ATFLLARGllapVKRLVEGTHKLA------------AGDFT-TRVTPTSRDELGRLAQDFNQLASTLEKNE 237
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 212 ARERNFTRDASHELRTPLTVIRvasdmalGD-ETLQPRLRR----SLQRIQRAGRDMEAVIDAF--LILAREADVEPQIE 284
Cdd:PRK10549 238 QMRRDFMADISHELRTPLAVLR-------GElEAIQDGVRKftpeSVASLQAEVGTLTKLVDDLhqLSLSDEGALAYRKT 310
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 285 LFDVNDIVRYEVDNANELLGNRPVSVHLHSEGPVQLHAPPRVLQVVVSNLVRNACSYTDEG---RIDVQVLNDRVVV--R 359
Cdd:PRK10549 311 PVDLVPLLEVAGGAFRERFASRGLTLQLSLPDSATVFGDPDRLMQLFNNLLENSLRYTDSGgslHISAEQRDKTLRLtfA 390
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 503802029 360 DTGIGMSAEALSRAFEPFYRAEPSRPQ---GTGLGLSIVRRLCDRFGWKVSLASEPGKGTEATVIF 422
Cdd:PRK10549 391 DSAPGVSDEQLQKLFERFYRTEGSRNRasgGSGLGLAICLNIVEAHNGRIIAAHSPFGGVSITVEL 456
|
|
| PRK10841 |
PRK10841 |
two-component system sensor histidine kinase RcsC; |
317-420 |
6.56e-17 |
|
two-component system sensor histidine kinase RcsC;
Pssm-ID: 182772 [Multi-domain] Cd Length: 924 Bit Score: 83.10 E-value: 6.56e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 317 PVQLHAPPRVLQVVVSNLVRNACSYTDEGRIDVQVLNDR----VVVRDTGIGMSAEALSRAFEPFYRAEP---SRPQGTG 389
Cdd:PRK10841 553 PVALNGDPMRLQQVISNLLSNAIKFTDTGCIVLHVRVDGdylsFRVRDTGVGIPAKEVVRLFDPFFQVGTgvqRNFQGTG 632
|
90 100 110
....*....|....*....|....*....|.
gi 503802029 390 LGLSIVRRLCDRFGWKVSLASEPGKGTEATV 420
Cdd:PRK10841 633 LGLAICEKLINMMDGDISVDSEPGMGSQFTI 663
|
|
| PRK15347 |
PRK15347 |
two component system sensor kinase; |
72-416 |
8.34e-17 |
|
two component system sensor kinase;
Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 82.77 E-value: 8.34e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 72 YLLESGQSALSLPANLRN--LEPGFHELPkDDQLVLVDVRPAGRLYLVFLRSRA---EMLAFWFGIVPVLLTLLA--VYG 144
Cdd:PRK15347 234 TIPLSSNQLQKILNQLENvkLHDGWQQIP-DYLVLRTQLKGPGWQQVTLYPRRNlanEALKPALQQLPFALLILVllTSV 312
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 145 ASWVTYRaskRLVSPvnwLARRVSRWDPGHPEAadLEPnKLPADMQGETRQLAAALHSLANRVSAH-------VA---RE 214
Cdd:PRK15347 313 LFLLLRR---YLAKP---LWRFVDIINKTGPAA--LEP-RLPENRLDELGSIAKAYNQLLDTLNEQydtlenkVAertQA 383
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 215 RNFTRDA---------------SHELRTPLTVIrVASDMALGDETLQPRLRRSLQRIQRAGRDMEAVIDAFLILAR-EAD 278
Cdd:PRK15347 384 LAEAKQRaeqankrksehlttiSHEIRTPLNGV-LGALELLQNTPLTAEQMDLADTARQCTLSLLAIINNLLDFSRiESG 462
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 279 vepQIELfdvndivRYE-------VDNANELLGNRPVS------VHLHSEGPVQLHAPP-RVLQVVVsNLVRNACSYTDE 344
Cdd:PRK15347 463 ---QMTL-------SLEetallplLDQAMLTIQGPAQSksltlrTFVGAHVPLYLHLDSlRLRQILV-NLLGNAVKFTET 531
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 503802029 345 GRI--DVQVLNDRVV--VRDTGIGMSAEALSRAFEPFYRAEpSRPQGTGLGLSIVRRLCDRFGWKVSLASEPGKGT 416
Cdd:PRK15347 532 GGIrlRVKRHEQQLCftVEDTGCGIDIQQQQQIFTPFYQAD-THSQGTGLGLTIASSLAKMMGGELTLFSTPGVGS 606
|
|
| PRK11107 |
PRK11107 |
hybrid sensory histidine kinase BarA; Provisional |
222-416 |
2.13e-16 |
|
hybrid sensory histidine kinase BarA; Provisional
Pssm-ID: 236848 [Multi-domain] Cd Length: 919 Bit Score: 81.43 E-value: 2.13e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 222 SHELRTPLT-VIRVASdmalgdETLQPRLRRS----LQRIQRAGRDMEAVIDAFLILAR-EADvepQIEL----FD---- 287
Cdd:PRK11107 301 SHELRTPLNgVIGFTR------QTLKTPLTPTqrdyLQTIERSANNLLAIINDILDFSKlEAG---KLVLenipFSlret 371
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 288 VNDIVRYEVDNAN----ELlgnrpvSVHLHSEGPVQLHAPPRVLQVVVSNLVRNACSYTDEGRIDVQV----LND----- 354
Cdd:PRK11107 372 LDEVVTLLAHSAHekglEL------TLNIDPDVPDNVIGDPLRLQQIITNLVGNAIKFTESGNIDILVelraLSNtkvql 445
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 503802029 355 RVVVRDTGIGMSAEALSRAFEPFYRAEPS---RPQGTGLGLSIVRRLCDRFGWKVSLASEPGKGT 416
Cdd:PRK11107 446 EVQIRDTGIGISERQQSQLFQAFRQADASisrRHGGTGLGLVITQKLVNEMGGDISFHSQPNRGS 510
|
|
| PRK13837 |
PRK13837 |
two-component system VirA-like sensor kinase; |
222-416 |
3.04e-16 |
|
two-component system VirA-like sensor kinase;
Pssm-ID: 237526 [Multi-domain] Cd Length: 828 Bit Score: 80.88 E-value: 3.04e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 222 SHELRTPLTVIRVASDMALGDETLQPRLRRSLQRIQRAGRDMEAVIDAFLILAR--EADVEPqielFDVNDIVRYEVDNA 299
Cdd:PRK13837 458 AHNFNNILGAILGYAEMALNKLARHSRAARYIDEIISAGARARLIIDQILAFGRkgERNTKP----FDLSELVTEIAPLL 533
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 300 NELLGnRPVSVHLHSEG-PVQLHAPPRVLQVVVSNLVRNACSYTDE-GRIDVQVlnDRVVVR------------------ 359
Cdd:PRK13837 534 RVSLP-PGVELDFDQDQePAVVEGNPAELQQVLMNLCSNAAQAMDGaGRVDISL--SRAKLRapkvlshgvlppgryvll 610
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 360 ---DTGIGMSAEALSRAFEPFYraePSRPQGTGLGLSIVRRLCDRFGWKVSLASEPGKGT 416
Cdd:PRK13837 611 rvsDTGAGIDEAVLPHIFEPFF---TTRAGGTGLGLATVHGIVSAHAGYIDVQSTVGRGT 667
|
|
| HATPase_CckA-like |
cd16919 |
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ... |
327-422 |
1.54e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).
Pssm-ID: 340396 [Multi-domain] Cd Length: 116 Bit Score: 72.41 E-value: 1.54e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 327 LQVVVSNLVRNAC-SYTDEGRIDVQVLNDRVV-------------------VRDTGIGMSAEALSRAFEPFYRAEPSrPQ 386
Cdd:cd16919 1 LELAILNLAVNARdAMPEGGRLTIETSNQRVDadyalnyrdlipgnyvcleVSDTGSGMPAEVLRRAFEPFFTTKEV-GK 79
|
90 100 110
....*....|....*....|....*....|....*.
gi 503802029 387 GTGLGLSIVRRLCDRFGWKVSLASEPGKGTEATVIF 422
Cdd:cd16919 80 GTGLGLSMVYGFVKQSGGHLRIYSEPGVGTTVRIYL 115
|
|
| cpxA |
PRK09470 |
envelope stress sensor histidine kinase CpxA; |
220-395 |
3.36e-15 |
|
envelope stress sensor histidine kinase CpxA;
Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 77.28 E-value: 3.36e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 220 DASHELRTPLTVIRVASdmALgdetlqprLRR------SLQRIQRAGRDMEAVIDAFLILAR-EADVEPQIELFDVNDI- 291
Cdd:PRK09470 249 DISHELRTPLTRLQLAT--AL--------LRRrqgeskELERIETEAQRLDSMINDLLVLSRnQQKNHLERETFKANSLw 318
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 292 ------VRYEVDNANELLgnrPVSVHLhseGPVQLHAPPRVLQVVVSNLVRNACSYT-DEGRIDVQVLND--RVVVRDTG 362
Cdd:PRK09470 319 sevledAKFEAEQMGKSL---TVSAPP---GPWPINGNPNALASALENIVRNALRYShTKIEVAFSVDKDglTITVDDDG 392
|
170 180 190
....*....|....*....|....*....|....*.
gi 503802029 363 IGMSAEALSRAFEPFYRAEPSRPQ---GTGLGLSIV 395
Cdd:PRK09470 393 PGVPEEEREQIFRPFYRVDEARDResgGTGLGLAIV 428
|
|
| HATPase_HupT_MifS-like |
cd16976 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
327-421 |
1.02e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.
Pssm-ID: 340435 [Multi-domain] Cd Length: 102 Bit Score: 69.79 E-value: 1.02e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 327 LQVVVSNLVRNACSYT---DEGRIDV--QVLNDRVV--VRDTGIGMSAEALSRAFEPFYRAEPSrPQGTGLGLSIVRRLC 399
Cdd:cd16976 1 IQQVLMNLLQNALDAMgkvENPRIRIaaRRLGGRLVlvVRDNGPGIAEEHLSRVFDPFFTTKPV-GKGTGLGLSISYGIV 79
|
90 100
....*....|....*....|..
gi 503802029 400 DRFGWKVSLASEPGKGTEATVI 421
Cdd:cd16976 80 EEHGGRLSVANEEGAGARFTFD 101
|
|
| HATPase_FilI-like |
cd16921 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
327-422 |
1.16e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 69.66 E-value: 1.16e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 327 LQVVVSNLVRNACSYTDEG---RIDVQVLND----RVVVRDTGIGMSAEALSRAFEPFYRAEP-SRPQGTGLGLSIVRRL 398
Cdd:cd16921 1 LGQVLTNLLGNAIKFRRPRrppRIEVGAEDVgeewTFYVRDNGIGIDPEYAEKVFGIFQRLHSrEEYEGTGVGLAIVRKI 80
|
90 100
....*....|....*....|....
gi 503802029 399 CDRFGWKVSLASEPGKGTeaTVIF 422
Cdd:cd16921 81 IERHGGRIWLESEPGEGT--TFYF 102
|
|
| HATPase_EcPhoR-like |
cd16952 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
327-422 |
1.32e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.
Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 69.54 E-value: 1.32e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 327 LQVVVSNLVRNACSYT-DEGRIDVQVLND----RVVVRDTGIGMSAEALSRAFEPFYRAEPSRPQ---GTGLGLSIVRRL 398
Cdd:cd16952 1 LRSAFSNLVSNAVKYTpPSDTITVRWSQEesgaRLSVEDTGPGIPPEHIPRLTERFYRVDIERCRntgGTGLGLAIVKHV 80
|
90 100
....*....|....*....|....
gi 503802029 399 CDRFGWKVSLASEPGKGTEATVIF 422
Cdd:cd16952 81 MSRHDARLLIASELGKGSRFTCLF 104
|
|
| PRK09959 |
PRK09959 |
acid-sensing system histidine kinase EvgS; |
192-420 |
6.46e-14 |
|
acid-sensing system histidine kinase EvgS;
Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 74.00 E-value: 6.46e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 192 ETRQLAAALHSLANR-VSAHVARERnFTRDASHELRTPLTVIRVASDMALGDETLQPRLRRSLQRIQRAGRDMEAVIDAF 270
Cdd:PRK09959 690 ETRDLIHALEVERNKaINATVAKSQ-FLATMSHEIRTPISSIMGFLELLSGSGLSKEQRVEAISLAYATGQSLLGLIGEI 768
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 271 LILAR--EADVEPQIELFDVNDIVRYEVDNANELLGNRPVSVHLHSEGPVQ--LHAPPRVLQVVVSNLVRNACSYTDEGR 346
Cdd:PRK09959 769 LDVDKieSGNYQLQPQWVDIPTLVQNTCHSFGAIAASKSIALSCSSTFPDHylVKIDPQAFKQVLSNLLSNALKFTTEGA 848
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 347 IDVQV----LND-----RVVVRDTGIGMSAEALSRAFEPFYRAEPSRPQ-GTGLGLSIVRRLCDRFGWKVSLASEPGKGT 416
Cdd:PRK09959 849 VKITTslghIDDnhaviKMTIMDSGSGLSQEEQQQLFKRYSQTSAGRQQtGSGLGLMICKELIKNMQGDLSLESHPGIGT 928
|
....
gi 503802029 417 EATV 420
Cdd:PRK09959 929 TFTI 932
|
|
| PRK10604 |
PRK10604 |
sensor protein RstB; Provisional |
196-423 |
1.51e-13 |
|
sensor protein RstB; Provisional
Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 71.94 E-value: 1.51e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 196 LAAALHSLANRVSAHVARERNFTRDASHELRTPLTVIRVASDMaLGDETLQPRlrrslQRIQRAGRDMEAVIDAFLILAR 275
Cdd:PRK10604 194 LGVAFNQMADNINALIASKKQLIDGIAHELRTPLVRLRYRLEM-SDNLSAAES-----QALNRDIGQLEALIEELLTYAR 267
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 276 --EADVEPQIELFDVNDIVRYEVDNANelLGNRPVSVHLHSEGPVQ-LHAPPRVLQVVVSNLVRNACSYTdEGRIDVQVL 352
Cdd:PRK10604 268 ldRPQNELHLSEPDLPAWLSTHLADIQ--AVTPEKTVRLDTPHQGDyGALDMRLMERVLDNLLNNALRYA-HSRVRVSLL 344
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 503802029 353 ND----RVVVRDTGIGMSAEALSRAFEPFYRAEPSRPQGT---GLGLSIVRRLCDRFGWKVSLASEPGKGteATVIFR 423
Cdd:PRK10604 345 LDgnqaCLIVEDDGPGIPPEERERVFEPFVRLDPSRDRATggcGLGLAIVHSIALAMGGSVNCDESELGG--ARFSFS 420
|
|
| HATPase_BaeS-like |
cd16946 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
324-422 |
2.67e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.
Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 65.95 E-value: 2.67e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 324 PRVLQVVVSNLVRNACSYTDEG-RIDVQVLND----RVVVRDTGIGMSAEALSRAFEPFYRAEPSRPQ---GTGLGLSIV 395
Cdd:cd16946 2 RDRLQQLFVNLLENSLRYTDTGgKLRIRAAQTpqevRLDVEDSAPGVSDDQLARLFERFYRVESSRNRasgGSGLGLAIC 81
|
90 100
....*....|....*....|....*..
gi 503802029 396 RRLCDRFGWKVSLASEPGKGTEATVIF 422
Cdd:cd16946 82 HNIALAHGGTISAEHSPLGGLRLVLTL 108
|
|
| HATPase_EnvZ-like |
cd16950 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
327-420 |
6.61e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.
Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 64.39 E-value: 6.61e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 327 LQVVVSNLVRNACSYtdeGRIDVQVLND------RVVVRDTGIGMSAEALSRAFEPFYRAEPSR-PQGTGLGLSIVRRLC 399
Cdd:cd16950 1 LKRVLSNLVDNALRY---GGGWVEVSSDgegnrtRIQVLDNGPGIAPEEVDELFQPFYRGDNARgTSGTGLGLAIVQRIS 77
|
90 100
....*....|....*....|.
gi 503802029 400 DRFGWKVSLASEPGKGTEATV 420
Cdd:cd16950 78 DAHGGSLTLANRAGGGLCARI 98
|
|
| PRK11091 |
PRK11091 |
aerobic respiration control sensor protein ArcB; Provisional |
222-420 |
7.32e-13 |
|
aerobic respiration control sensor protein ArcB; Provisional
Pssm-ID: 236842 [Multi-domain] Cd Length: 779 Bit Score: 70.35 E-value: 7.32e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 222 SHELRTPLTVIRVASDMALgDETLQPRLRRSLQRIQRA----GRDMEAVIDAFLILAREADVEPQIelFDVNDIVRyEVD 297
Cdd:PRK11091 291 SHELRTPLNGIVGLSRILL-DTELTAEQRKYLKTIHVSaitlGNIFNDIIDMDKMERRKLQLDNQP--IDFTDFLA-DLE 366
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 298 NANELLGnRPVSVHLHSEgpVQLHAPPRV------LQVVVSNLVRNACSYTDEGRIDVQVL---NDRV--VVRDTGIGMS 366
Cdd:PRK11091 367 NLSGLQA-EQKGLRFDLE--PLLPLPHKVitdgtrLRQILWNLISNAVKFTQQGGVTVRVRyeeGDMLtfEVEDSGIGIP 443
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 503802029 367 AEALSRAFEPFYRAEPS---RPQ-GTGLGLSIVRRLCDRFGWKVSLASEPGKGTEATV 420
Cdd:PRK11091 444 EDELDKIFAMYYQVKDShggKPAtGTGIGLAVSKRLAQAMGGDITVTSEEGKGSCFTL 501
|
|
| HATPase_YcbM-like |
cd16947 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
315-420 |
1.10e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).
Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 64.46 E-value: 1.10e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 315 EGPVQLHAPPRVLQVVVSNLVRNACSYTDEGRIDVQVLNDR-----VVVRDTGIGMSAEALSRAFEPFYRAEPSRP---Q 386
Cdd:cd16947 9 DRPIYANANTEALQRILKNLISNAIKYGSDGKFLGMTLREDekhvyIDIWDKGKGISETEKDHVFERLYTLEDSRNsakQ 88
|
90 100 110
....*....|....*....|....*....|....
gi 503802029 387 GTGLGLSIVRRLCDRFGWKVSLASEPGKGTEATV 420
Cdd:cd16947 89 GNGLGLTITKRLAESMGGSIYVNSKPYEKTVFTV 122
|
|
| HisKA |
pfam00512 |
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ... |
215-275 |
1.22e-12 |
|
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.
Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 62.61 E-value: 1.22e-12
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 503802029 215 RNFTRDASHELRTPLTVIRVASDMaLGDETLQPRLRRSLQRIQRAGRDMEAVIDAFLILAR 275
Cdd:pfam00512 3 SEFLANLSHELRTPLTAIRGYLEL-LRDEKLDEEQREYLETILRSAERLLRLINDLLDLSR 62
|
|
| HisKA |
cd00082 |
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ... |
212-275 |
1.66e-12 |
|
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.
Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 62.23 E-value: 1.66e-12
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 503802029 212 ARERNFTRDASHELRTPLTVIRVASDMALGDETLQPRLRRSLQRIQRAGRDMEAVIDAFLILAR 275
Cdd:cd00082 2 QAKGEFLANVSHELRTPLTAIRGALELLEEELLDDEEQREYLERIREEAERLLRLINDLLDLSR 65
|
|
| HATPase_SpaK_NisK-like |
cd16975 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
330-420 |
3.14e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.
Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 62.86 E-value: 3.14e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 330 VVSNLVRNACSYTDEGR-IDVQVLNDR----VVVRDTGIGMSAEALSRAFEPFYRAEPSRPQGT--GLGLSIVRRLCDRF 402
Cdd:cd16975 8 ALINIISNACQYAPEGGtVSISIYDEEeylyFEIWDNGHGFSEQDLKKALELFYRDDTSRRSGGhyGMGLYIAKNLVEKH 87
|
90
....*....|....*...
gi 503802029 403 GWKVSLASEPGKGTEATV 420
Cdd:cd16975 88 GGSLIIENSQKGGAEVTV 105
|
|
| PRK10364 |
PRK10364 |
two-component system sensor histidine kinase ZraS; |
222-420 |
3.72e-12 |
|
two-component system sensor histidine kinase ZraS;
Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 67.89 E-value: 3.72e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 222 SHELRTPLTVIR-----VASDMALGDET--LQPRLRRSLQRIQRagrdmeaVIDAFLILAREADVEPQIelFDVNDIVRY 294
Cdd:PRK10364 245 AHEIRNPLSSIKglakyFAERAPAGGEAhqLAQVMAKEADRLNR-------VVSELLELVKPTHLALQA--VDLNDLINH 315
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 295 EVDNANELLGNRPVSVHLH-SEGPVQLHA-PPRVLQVVVsNLVRNACSYTDE-GRIDVQV--LNDRV--VVRDTGIGMSA 367
Cdd:PRK10364 316 SLQLVSQDANSREIQLRFTaNDTLPEIQAdPDRLTQVLL-NLYLNAIQAIGQhGVISVTAseSGAGVkiSVTDSGKGIAA 394
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 503802029 368 EALSRAFEPFYraePSRPQGTGLGLSIVRRLCDRFGWKVSLASEPGKGTEATV 420
Cdd:PRK10364 395 DQLEAIFTPYF---TTKAEGTGLGLAVVHNIVEQHGGTIQVASQEGKGATFTL 444
|
|
| PRK09303 |
PRK09303 |
histidine kinase; |
223-415 |
3.73e-12 |
|
histidine kinase;
Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 67.28 E-value: 3.73e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 223 HELRTPLTvirvASDMALgdETLQ-----------PRLRRSLQR-IQRAGRDMEAVIDAFLILAR----EADVEPQ-IEL 285
Cdd:PRK09303 160 HDLRTPLT----AASLAL--ETLElgqidedtelkPALIEQLQDqARRQLEEIERLITDLLEVGRtrweALRFNPQkLDL 233
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 286 FDVNDIVRYEVdnaNELLGNRpvSVHLHSEGPVQL---HAPPRVLQVVVSNLVRNACSYT-DEGRIDVQVLnDR------ 355
Cdd:PRK09303 234 GSLCQEVILEL---EKRWLAK--SLEIQTDIPSDLpsvYADQERIRQVLLNLLDNAIKYTpEGGTITLSML-HRttqkvq 307
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 503802029 356 VVVRDTGIGMSAEALSRAFEPFYRAEPSRPQ-GTGLGLSIVRRLCDRFGWKVSLASEPGKG 415
Cdd:PRK09303 308 VSICDTGPGIPEEEQERIFEDRVRLPRDEGTeGYGIGLSVCRRIVRVHYGQIWVDSEPGQG 368
|
|
| HATPase_TmoS-FixL-DctS-like |
cd16920 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
327-416 |
1.49e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 60.87 E-value: 1.49e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 327 LQVVVSNLVRNACSYTDEGRIDVQVLNDR----------VVVRDTGIGMSAEALSRAFEPFYraePSRPQGTGLGLSIVR 396
Cdd:cd16920 1 IQQVLINLVRNGIEAMSEGGCERRELTIRtspaddravtISVKDTGPGIAEEVAGQLFDPFY---TTKSEGLGMGLSICR 77
|
90 100
....*....|....*....|
gi 503802029 397 RLCDRFGWKVSLASEPGKGT 416
Cdd:cd16920 78 SIIEAHGGRLSVESPAGGGA 97
|
|
| HisKA |
smart00388 |
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ... |
215-275 |
1.80e-11 |
|
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.
Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 59.12 E-value: 1.80e-11
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 503802029 215 RNFTRDASHELRTPLTVIRVASDMaLGDETLQPRLRRSLQRIQRAGRDMEAVIDAFLILAR 275
Cdd:smart00388 3 REFLANLSHELRTPLTAIRGYLEL-LLDTELSEEQREYLETILREAERLLRLINDLLDLSR 62
|
|
| YesM |
COG2972 |
Sensor histidine kinase YesM [Signal transduction mechanisms]; |
118-422 |
2.05e-11 |
|
Sensor histidine kinase YesM [Signal transduction mechanisms];
Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 65.42 E-value: 2.05e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 118 FLRSRAEMLAFWFGIVPVLLTLLAVygasWVTYRASKRLVSPVNWLARRVSRWDPGHPEAADLEPNKlpadmqgETRQLA 197
Cdd:COG2972 147 ELFRGLFSLRRLILLIILLLLLLAL----LLSYLLSRSITRPIKRLKKAMKKVEKGDLVRLEVSGND-------EIGILA 215
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 198 AALHSLANRVSAHVARERNFTRDASH-ELRTpltvirvasdmalgdetLQPRLRR-----SLQRIQRAGR--DMEAVIDA 269
Cdd:COG2972 216 RSFNEMVERIKELIEEVYELELEKKEaELKA-----------------LQAQINPhflfnTLNSIRWLAEleDPEEAEEM 278
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 270 FLILAReadvepqieLF-----DVNDIV--RYEVDNANELL-------GNRpVSVHLH-SEGPVQLHAPPRVLQVvvsnL 334
Cdd:COG2972 279 LEALSK---------LLryslsKGDELVtlEEELELIKSYLeiqklrfGDR-LEVEIEiDEELLDLLIPKLILQP----L 344
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 335 VRNAC-----SYTDEGRIDVQVLND----RVVVRDTGIGMSAEALSRAFEPFyraePSRPQGTGLGLSIVR-RLCDRFG- 403
Cdd:COG2972 345 VENAIehgiePKEGGGTIRISIRKEgdrlVITVEDNGVGMPEEKLEKLLEEL----SSKGEGRGIGLRNVReRLKLYYGe 420
|
330 340
....*....|....*....|
gi 503802029 404 -WKVSLASEPGKGTEATVIF 422
Cdd:COG2972 421 eYGLEIESEPGEGTTVTIRI 440
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
192-422 |
1.28e-10 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 62.56 E-value: 1.28e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 192 ETRQLAAALHSLANRVSAhvarernfTRDASHELRTPLTVIRVASDMALGDETLQpRLRRSLQRIQRAGRDM-----EAV 266
Cdd:COG3290 175 ELERLEEELEGVKELAEA--------LRAQRHDFRNHLHTISGLLQLGEYDEALE-YIDEISEELQELIDSLlsrigNPV 245
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 267 IDAFLI----LAREADVEpqielfdvndivryevdnanellgnrpVSVHLHSEGPvQLHAPPRVLQVVVSNLVRNA---- 338
Cdd:COG3290 246 LAALLLgkaaRARERGID---------------------------LTIDIDSDLP-DLPLSDTDLVTILGNLLDNAieav 297
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 339 -CSYTDEGRIDVQVLND----RVVVRDTGIGMSAEALSRAFEPFYraePSRP-QGTGLGLSIVRRLCDRFGWKVSLASEP 412
Cdd:COG3290 298 eKLPEEERRVELSIRDDgdelVIEVEDSGPGIPEELLEKIFERGF---STKLgEGRGLGLALVKQIVEKYGGTIEVESEE 374
|
250
....*....|
gi 503802029 413 GKGTEATVIF 422
Cdd:COG3290 375 GEGTVFTVRL 384
|
|
| HATPase_NtrY-like |
cd16944 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
325-422 |
4.26e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.
Pssm-ID: 340420 [Multi-domain] Cd Length: 108 Bit Score: 56.78 E-value: 4.26e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 325 RVLQVVVSNLVRNACSYTD-------EGRIDV---QVLNDRVVVRDTGIGMSAEALSRAFEPFYraePSRPQGTGLGLSI 394
Cdd:cd16944 3 TQISQVLTNILKNAAEAIEgrpsdvgEVRIRVeadQDGRIVLIVCDNGKGFPREMRHRATEPYV---TTRPKGTGLGLAI 79
|
90 100
....*....|....*....|....*...
gi 503802029 395 VRRLCDRFGWKVSLASEPGKGTEATVIF 422
Cdd:cd16944 80 VKKIMEEHGGRISLSNREAGGACIRIIL 107
|
|
| HATPase_CpxA-like |
cd16949 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
333-421 |
6.60e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.
Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 56.18 E-value: 6.60e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 333 NLVRNACSYTDEG-RIDVQVLNDRVV--VRDTGIGMSAEALSRAFEPFYRAEPSRPQ---GTGLGLSIVRRLCDRFGWKV 406
Cdd:cd16949 7 NVLRNALRYSPSKiLLDISQDGDQWTitITDDGPGVPEDQLEQIFLPFYRVDSARDResgGTGLGLAIAERAIEQHGGKI 86
|
90
....*....|....*
gi 503802029 407 SLASEPGKGTEATVI 421
Cdd:cd16949 87 KASNRKPGGLRVRIW 101
|
|
| HATPase_Glnl-NtrB-like |
cd16918 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
327-413 |
8.85e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).
Pssm-ID: 340395 [Multi-domain] Cd Length: 109 Bit Score: 55.87 E-value: 8.85e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 327 LQVVVSNLVRNACSYTDEG--------RIDVQV--------LNDRVVVRDTGIGMSAEALSRAFEPFYRaepSRPQGTGL 390
Cdd:cd16918 1 LIQVFLNLVRNAAQALAGSggeiilrtRTQRQVtlghprhrLALRVSVIDNGPGIPPDLQDTIFYPMVS---GRENGTGL 77
|
90 100
....*....|....*....|...
gi 503802029 391 GLSIVRRLCDRFGWKVSLASEPG 413
Cdd:cd16918 78 GLAIAQNIVSQHGGVIECDSQPG 100
|
|
| HATPase_RstB-like |
cd16939 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
327-412 |
1.00e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.
Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 55.51 E-value: 1.00e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 327 LQVVVSNLVRNACSYTDEgRIDVQVLND----RVVVRDTGIGMSAEALSRAFEPFYRAEPSRPQGT---GLGLSIVRRLC 399
Cdd:cd16939 1 MARALDNLLRNALRYAHR-TVRIALLVSggrlTLIVEDDGPGIPAAARERVFEPFVRLDPSRDRATggfGLGLAIVHRVA 79
|
90
....*....|...
gi 503802029 400 DRFGWKVSLASEP 412
Cdd:cd16939 80 LWHGGHVECDDSE 92
|
|
| HATPase_YpdA-YehU-LytS-like |
cd16924 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
323-421 |
1.06e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YpdA, YehU, Bacillus subtilis LytS, and some hybrid sensor histidine kinases; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. It also includes the HATPase domains of Escherichia coli YpdA and YehU, HKs of YpdA-YpdB and YehU-YehTCSs, which are involved together in a nutrient sensing regulatory network. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), some having accessory sensor domain(s) such as Cache, HAMP or GAF; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340401 [Multi-domain] Cd Length: 103 Bit Score: 55.53 E-value: 1.06e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 323 PPRVLQVVVSNLVRNACS-YTDEGRIDVQVLND----RVVVRDTGIGMSAEALSrafepfyRAEPSRPQGTGLGLSIVR- 396
Cdd:cd16924 2 PPFTLQPLVENAIQHGLSpLTDKGVVTISALKEdnhvMIEVEDNGRGIDPKVLN-------ILGKKPKEGNGIGLYNVHq 74
|
90 100
....*....|....*....|....*..
gi 503802029 397 RLCDRFG--WKVSLASEPGKGTEATVI 421
Cdd:cd16924 75 RLILLFGedYGIHIASEPDKGTRITFT 101
|
|
| COG4192 |
COG4192 |
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ... |
132-421 |
1.48e-09 |
|
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];
Pssm-ID: 443346 [Multi-domain] Cd Length: 640 Bit Score: 60.09 E-value: 1.48e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 132 IVPVLLTLLAVYGASWvtYRASKRLVSPVNWLARRVSRWDPGHPEAadlepnKLPADMQGE-----------TRQLAAAL 200
Cdd:COG4192 329 LAIALLSLLLAVLINY--FYVRRRLVKRLNALSDAMAAIAAGDLDV------PIPVDGNDEigriarllrvfRDQAIEKT 400
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 201 HSLANRVSAHVARERN--------------------FTRDAsHELRTPLTVIRV---ASDMALGDETLQpRLRRSLQRIQ 257
Cdd:COG4192 401 QELETEIEERKRIEKNlrqtqdeliqaakmavvgqtMTSLA-HELNQPLNAMSMylfSAKKALEQENYA-QLPTSLDKIE 478
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 258 RAGRDMEAVIDAFLILAREADVEPQieLFDVNDIVryevDNANELLGNR--PVSVHLHSEGPVQLHAPPRVLQVVVSNLV 335
Cdd:COG4192 479 GLIERMDKIIKSLRQFSRKSDTPLQ--PVDLRQVI----EQAWELVESRakPQQITLHIPDDLMVQGDQVLLEQVLVNLL 552
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 336 RNAC-SYTDEGRIDVQVL----NDRVVVRDTGIGMS-AEALsraFEPFYraePSRPQGTGLGLSIVRRLCDRFGWKVSLA 409
Cdd:COG4192 553 VNALdAVATQPQISVDLLsnaeNLRVAISDNGNGWPlVDKL---FTPFT---TTKEVGLGLGLSICRSIMQQFGGDLYLA 626
|
330
....*....|..
gi 503802029 410 SEPGKGteATVI 421
Cdd:COG4192 627 STLERG--AMVI 636
|
|
| PRK10815 |
PRK10815 |
two-component system sensor histidine kinase PhoQ; |
122-423 |
2.23e-09 |
|
two-component system sensor histidine kinase PhoQ;
Pssm-ID: 182754 [Multi-domain] Cd Length: 485 Bit Score: 59.26 E-value: 2.23e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 122 RAEMLAFWFGIVpVLLTLLAVYGASWVTYRASKRlvsPVNWLARRVSRWDPGHPEAADLEPnklPADMQGETRQLAAALH 201
Cdd:PRK10815 185 RSYMVWSWFSYV-LLANLLLVIPLLWLAAWWSLR---PIEALAKQVRELEEGEREQLDPNP---PRELTSLVRNLNRLLK 257
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 202 SLANRVSahvaRERNFTRDASHELRTPLTVirvasdmalgdetLQPRLRrSLqriqRAGRDMEavIDaflilareaDVEP 281
Cdd:PRK10815 258 NERERYT----KYRTTLTDLTHSLKTPLAV-------------LQSTLR-SL----RSGKQMS--VE---------QAEP 304
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 282 qIELFDVNDI---VRYEVDNANELLGNRPVSVHLHSEGP-------------------VQLHAPPRVLQV--------VV 331
Cdd:PRK10815 305 -IMLEQISRIsqqIGYYLHRASMRSEHNLLSRELHSVAPlldnltsalnkvyqrkgvnITLDISPEITFVgekndfmeVM 383
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 332 SNLVRNACSYTDEG-RIDVQVLND--RVVVRDTGIGMSAEALSRAFEPFYRAEPSRPqGTGLGLSIVRRLCDRFGWKVSL 408
Cdd:PRK10815 384 GNVLDNACKYCLEFvEISARQTDEhlHIVVEDDGPGIPESKRELIFDRGQRADTLRP-GQGLGLSVAREITEQYEGKISA 462
|
330
....*....|....*
gi 503802029 409 ASEPGKGTEATVIFR 423
Cdd:PRK10815 463 GDSPLGGARMEVIFG 477
|
|
| HATPase_TutC-TodS-like |
cd16925 |
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ... |
324-420 |
5.14e-09 |
|
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.
Pssm-ID: 340402 [Multi-domain] Cd Length: 110 Bit Score: 53.65 E-value: 5.14e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 324 PRVLQVVVSNLVRNACSYT-DEGRIDVQVLNDR-----VVVRDTGIGMSAEALSRAFEPFYRAEPSRPQ---GTGLGLSI 394
Cdd:cd16925 2 AEKYERVVLNLLSNAFKFTpDGGRIRCILEKFRlnrflLTVSDSGPGIPPNLREEIFERFRQGDGSSTRahgGTGLGLSI 81
|
90 100
....*....|....*....|....*.
gi 503802029 395 VRRLCDRFGWKVSLASEPGKGTEATV 420
Cdd:cd16925 82 VKEFVELHGGTVTVSDAPGGGALFQV 107
|
|
| HATPase_VanS-like |
cd16923 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
327-396 |
9.40e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.
Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 52.77 E-value: 9.40e-09
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 503802029 327 LQVVVSNLVRNACSYTDEG---RIDVQVLNDRVVVR--DTGIGMSAEALSRAFEPFYRAEPSR-PQGTGLGLSIVR 396
Cdd:cd16923 1 LQRVFSNLLSNAIKYSPENtriYITSFLTDDVVNIMfkNPSSHPLDFKLEKLFERFYRGDNSRnTEGAGLGLSIAK 76
|
|
| ActS_PrrB_HisK |
NF033792 |
ActS/PrrB/RegB family redox-sensitive histidine kinase; This redox-responsive histidine kinase, ... |
221-421 |
1.34e-08 |
|
ActS/PrrB/RegB family redox-sensitive histidine kinase; This redox-responsive histidine kinase, found in alpha-proteobacteria, shows strong sequence conservation, including the notable motif [VA]AAAAHELGTPxTI. It always acts as a partner to an ActR/PrrA/RegA family global response regulator transcription factor in a two-component sensory transduction system. Lineage-specific names and gene symbols given to this histidine kinase reflect downstream regulator changes such as entry into stationary phase, anaerobic expression of photosynthesis genes, and survival of exposure to low pH.
Pssm-ID: 468186 [Multi-domain] Cd Length: 423 Bit Score: 56.37 E-value: 1.34e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 221 ASHELRTPLTVIR-VASDMA--LGD-----ETLQ------PRLRRSLQRIQRAGRDMEAVID--AFLILAREAdVEPQIE 284
Cdd:NF033792 209 AAHELGTPLATIAlVAKELEreLPDdpplrEDAEllrsqaERCRDILRRLTSLGEEGDAHLDrlPLSALIEEA-AAPHRG 287
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 285 lFDVNDIVRYEVDNANELLGNRPVSVhlhsegpvqLHApprvlqvvVSNLVRNACSY-TDEGRIDVQVLNDRV--VVRDT 361
Cdd:NF033792 288 -FGKEIEVVVAGDPGEEPVIRRNPEI---------LYG--------LGNLIENAVDFaRSTVTVTASWDAESVtiTIEDD 349
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 503802029 362 GIGMSAEALSRAFEPFY---RAEPSRP--QGTGLGLSIVRRLCDRFGWKVSLA--SEPGKGTEATVI 421
Cdd:NF033792 350 GPGFPPDVLSRIGEPYVttrRGEERRPggGGLGLGLFIAKTLLERSGATVTFAnrPPPEGGAVVTVR 416
|
|
| HATPase_CreC-like |
cd16945 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
324-419 |
2.70e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.
Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 51.69 E-value: 2.70e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 324 PRVLQVVVSNLVRNACSYTDEG---RIDVQVLND--RVVVRDTGIGMSAEALSRAFEPFYR-AEPSRPQ-GTGLGLSIVR 396
Cdd:cd16945 2 PFLLRQAINNLLDNAIDFSPEGgliALQLEADTEgiELLVFDEGSGIPDYALNRVFERFYSlPRPHSGQkSTGLGLAFVQ 81
|
90 100
....*....|....*....|...
gi 503802029 397 RLCDRFGWKVSLASEPGkGTEAT 419
Cdd:cd16945 82 EVAQLHGGRITLRNRPD-GVLAF 103
|
|
| RsbW |
COG2172 |
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; |
327-423 |
3.86e-08 |
|
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
Pssm-ID: 441775 [Multi-domain] Cd Length: 127 Bit Score: 51.45 E-value: 3.86e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 327 LQVVVSNLVRNACSYTD----EGRIDVQVLND----RVVVRDTGIGMSAEALSRAFEPfyraepsrPQGTGLGLSIVRRL 398
Cdd:COG2172 35 LVLAVSEAVTNAVRHAYggdpDGPVEVELELDpdglEIEVRDEGPGFDPEDLPDPYST--------LAEGGRGLFLIRRL 106
|
90 100
....*....|....*....|....*
gi 503802029 399 CDRFGWKvslaSEPGkGTEATVIFR 423
Cdd:COG2172 107 MDEVEYE----SDPG-GTTVRLVKR 126
|
|
| HATPase_PhoQ-like |
cd16954 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
318-422 |
6.92e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.
Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 51.09 E-value: 6.92e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 318 VQLHAPPRV--------LQVVVSNLVRNACSYTDEgRIDVQVLND----RVVVRDTGIGMSAEALSRAFEPFYRAEPSRP 385
Cdd:cd16954 21 ISLDISPELrfpgerndLMELLGNLLDNACKWCLE-FVEVTARQTdgglHLIVDDDGPGVPESQRSKIFQRGQRLDEQRP 99
|
90 100 110
....*....|....*....|....*....|....*..
gi 503802029 386 qGTGLGLSIVRRLCDRFGWKVSLASEPGKGTEATVIF 422
Cdd:cd16954 100 -GQGLGLAIAKEIVEQYGGELSLSDSPLGGARFEVVF 135
|
|
| HATPase_DpiB-CitA-like |
cd16915 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
327-420 |
1.19e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.
Pssm-ID: 340392 [Multi-domain] Cd Length: 104 Bit Score: 49.59 E-value: 1.19e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 327 LQVVVSNLVRNA---------------CSYTDEGRIDVqvlndrVVVRDTGIGMSAEALSRAFEPFYRAEPSRpqGTGLG 391
Cdd:cd16915 1 LITIVGNLIDNAldalaatgapnkqveVFLRDEGDDLV------IEVRDTGPGIAPELRDKVFERGVSTKGQG--ERGIG 72
|
90 100
....*....|....*....|....*....
gi 503802029 392 LSIVRRLCDRFGWKVSLASEPGKGTEATV 420
Cdd:cd16915 73 LALVRQSVERLGGSITVESEPGGGTTFSI 101
|
|
| PRK13557 |
PRK13557 |
histidine kinase; Provisional |
356-422 |
1.64e-07 |
|
histidine kinase; Provisional
Pssm-ID: 237425 [Multi-domain] Cd Length: 540 Bit Score: 53.52 E-value: 1.64e-07
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 503802029 356 VVVRDTGIGMSAEALSRAFEPFYRAEpSRPQGTGLGLSIVRRLCDRFGWKVSLASEPGKGTEATVIF 422
Cdd:PRK13557 327 IAVTDTGSGMPPEILARVMDPFFTTK-EEGKGTGLGLSMVYGFAKQSGGAVRIYSEVGEGTTVRLYF 392
|
|
| HATPase_BvrS-ChvG-like |
cd16953 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
330-403 |
2.01e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.
Pssm-ID: 340429 [Multi-domain] Cd Length: 110 Bit Score: 49.11 E-value: 2.01e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 330 VVSNLVRNACSYT--DEGRIDVQVLND----RVVVRDTGIGMSAEALSRAFEPFYRAEPSRP---QGTGLGLSIVRRLCD 400
Cdd:cd16953 4 VLRNLIGNAISFSppDTGRITVSAMPTgkmvTISVEDEGPGIPQEKLESIFDRFYTERPANEafgQHSGLGLSISRQIIE 83
|
...
gi 503802029 401 RFG 403
Cdd:cd16953 84 AHG 86
|
|
| PRK11086 |
PRK11086 |
sensory histidine kinase DcuS; Provisional |
326-420 |
4.66e-06 |
|
sensory histidine kinase DcuS; Provisional
Pssm-ID: 236839 [Multi-domain] Cd Length: 542 Bit Score: 48.76 E-value: 4.66e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 326 VLQVVVSNLVRN---ACSYTDEGRIDVQV--LNDRV--VVRDTGIGMSAEALSRAFEPFYRaepSRPQGTGLGLSIVRRL 398
Cdd:PRK11086 433 ELITILGNLIENaleAVGGEEGGEISVSLhyRNGWLhcEVSDDGPGIAPDEIDAIFDKGYS---TKGSNRGVGLYLVKQS 509
|
90 100
....*....|....*....|..
gi 503802029 399 CDRFGWKVSLASEPGKGTEATV 420
Cdd:PRK11086 510 VENLGGSIAVESEPGVGTQFFV 531
|
|
| marine_sort_HK |
TIGR03785 |
proteobacterial dedicated sortase system histidine kinase; This histidine kinase protein is ... |
119-400 |
8.41e-06 |
|
proteobacterial dedicated sortase system histidine kinase; This histidine kinase protein is paired with an adjacent response regulator (TIGR03787) gene. It co-occurs with a variant sortase enzyme (TIGR03784), usually in the same gene neighborhood, in proteobacterial species most of which are marine, and with an LPXTG motif-containing sortase target conserved protein (TIGR03788). Sortases and LPXTG proteins are far more common in Gram-positive bacteria, where sortase systems mediate attachment to the cell wall or cross-linking of pilin structures. We give this predicted sensor histidine kinase the gene symbol psdS, for Proteobacterial Dedicated Sortase system Sensor histidine kinase.
Pssm-ID: 163497 [Multi-domain] Cd Length: 703 Bit Score: 48.20 E-value: 8.41e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 119 LRSRAEMLAFWFGIVPVLLTLLAVYG-ASWVTYRAskrlvspvnwlaRRVSRwdpgHPEAADLEPNKLPADMQG-----E 192
Cdd:TIGR03785 400 LRNSALEKLFNVILAIMSIGTLALFGfASWISWRI------------RRLSD----DAEAAIDSQGRISGAIPAsrsrdE 463
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 193 TRQLAAALHSLANRVSAHVARERNFTRDASHELRTPLTVIRVASD----MALGDETLQ---------PRLRRSLQRIQRA 259
Cdd:TIGR03785 464 IGDLSRSFAQMVARLRQYTHYLENMSSRLSHELRTPVAVVRSSLEnlelQALEQEKQKyleraregtERLSMILNNMSEA 543
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 260 GRDMEAVIDaflilareADVEPqielFDVNDIVRYEVDNANELLGNRPVSVHLhSEGPVQLHAPPRVLQVVVSNLVRNAC 339
Cdd:TIGR03785 544 TRLEQAIQS--------AEVED----FDLSEVLSGCMQGYQMTYPPQRFELNI-PETPLVMRGSPELIAQMLDKLVDNAR 610
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 503802029 340 SYT-DEGRIDVQV-LNDR---VVVRDTGIGMSAEALSRAFEPFYRAEPSRPQGT---GLGLSIVRRLCD 400
Cdd:TIGR03785 611 EFSpEDGLIEVGLsQNKShalLTVSNEGPPLPEDMGEQLFDSMVSVRDQGAQDQphlGLGLYIVRLIAD 679
|
|
| HATPase_RsbT-like |
cd16934 |
Histidine kinase-like ATPase domain of the anti sigma-B factor Bacillus subtilis serine ... |
327-422 |
9.21e-06 |
|
Histidine kinase-like ATPase domain of the anti sigma-B factor Bacillus subtilis serine/threonine-protein kinase RsbT, and related domains; This family includes the histidine kinase-like ATPase (HATPase) domain of Bacillus subtilis serine/threonine-protein kinase RsbT, a component of the stressosome signaling complex of Bacillus subtilis. The stressosome is formed from multiple copies of three proteins, a sensor protein RsbR, a scaffold protein RsbS, and RsbT, and responds to environmental changes by initiating a protein partner switching cascade. Stress perception increases the phosphorylation of RsbR and RsbS, by RsbT. Subsequent dissociation of RsbT from the stressosome activates the sigma-B cascade, leading to the release of the alternative sigma factor, sigma-B.
Pssm-ID: 340411 [Multi-domain] Cd Length: 117 Bit Score: 44.67 E-value: 9.21e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 327 LQVVVSNLVRNACSYTDEGRIDVQVLND------RVVVRDTGIGMS--AEALSRAFepfyraepSRPQGTGLGLSIVRRL 398
Cdd:cd16934 26 IATAVTELARNLLKHAGGGQVLLEVVAEggrvalEILAVDQGPGIAdvDEALRDGF--------STGGGLGLGLGGVRRL 97
|
90 100
....*....|....*....|....
gi 503802029 399 CDRFgwkvSLASEPGKGTEATVIF 422
Cdd:cd16934 98 ADEF----DLHSAPGRGTVVVARK 117
|
|
| COG3920 |
COG3920 |
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ... |
9-422 |
1.04e-05 |
|
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];
Pssm-ID: 443125 [Multi-domain] Cd Length: 495 Bit Score: 47.59 E-value: 1.04e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 9 IRIAFILQAVLASLGILLGAWLVSLVIKHSLVGAALREEAAYYWTLHEASPVQPPPNTQNIRGYLLESGQSALSLPANLR 88
Cdd:COG3920 58 LSAAALAAALAVALAAAVGAAAALLALLVLLLLLLLAAAALALALLLAALAGLLLLAALLLLRLVALLAALALLALLLLL 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 89 NLEPGFHELPKDDQLVLVDVRPAGRLYLVFLRSRAEMLAFWFGIVPVLLTLLAVYGASWVTYRASKRLVSPVNWLARRVS 168
Cdd:COG3920 138 LLLLAILALAELAVALAELAAALLLLAEELAALRLAAAALLLLLAALLDLGLALAALAAAALLALLLALELLLALLLLLL 217
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 169 RWDPGHPEAADLEPNKLPADMQGETRQLAAALHSLANRVSAHVARERNFTRDASHELRTPLTVIRVASDMALGDETLQPR 248
Cdd:COG3920 218 LLLALLLVLLAALLRLRAAVLEELERRRRARGLGRLLLLLLLLLLLLRALLLLAAGIRLVITERKRAEEELEASLEEKEL 297
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 249 LRR--------------SLQRIQRAGRDMEAVIDAFL--------------ILAREADVEPqielFDVNDIVRYEVDNAN 300
Cdd:COG3920 298 LLRelhhrvknnlqvvsSLLRLQARRADDPEAREALEesqnriqalalvheLLYQSEDWEG----VDLRDYLRELLEPLR 373
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 301 ELLGNRPVSVHLHSEgPVQLhaPPRVLQ---VVVSNLVRNACSY----TDEGRIDVQVLND----RVVVRDTGIGMSAEA 369
Cdd:COG3920 374 DSYGGRGIRIELDGP-DVEL--PADAAVplgLILNELVTNALKHaflsGEGGRIRVSWRREdgrlRLTVSDNGVGLPEDV 450
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|...
gi 503802029 370 lsrafepfyraepSRPQGTGLGLSIVRRLCDRFGWKVSLasEPGKGTEATVIF 422
Cdd:COG3920 451 -------------DPPARKGLGLRLIRALVRQLGGTLEL--DRPEGTRVRITF 488
|
|
| HATPase_LytS-like |
cd16957 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
323-419 |
2.10e-05 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis LytS and Staphylococcus aureus LytS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), and a GAF sensor domain; most contain a DUF3816 domain.
Pssm-ID: 340433 [Multi-domain] Cd Length: 106 Bit Score: 43.18 E-value: 2.10e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 323 PPRVLQVVVSNLVRNACSYTDEG-RIDVQVLND----RVVVRDTGIGMSAEALSRAFEPFYRAEpsrpQGTGLGL-SIVR 396
Cdd:cd16957 2 PPFALQVLVENAIRHAFPKRKENnEVRVVVKKDqhkvHVSVSDNGQGIPEERLDLLGKTTVTSE----KGTGTALeNLNR 77
|
90 100
....*....|....*....|....*
gi 503802029 397 RLCDRFGWKVSL--ASEPGKGTEAT 419
Cdd:cd16957 78 RLIGLFGSEACLhiESEVHGGTEVW 102
|
|
| glnL |
PRK11073 |
nitrogen regulation protein NR(II); |
186-420 |
3.89e-05 |
|
nitrogen regulation protein NR(II);
Pssm-ID: 182947 [Multi-domain] Cd Length: 348 Bit Score: 45.46 E-value: 3.89e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 186 PADMQgetRQLAAALHSLANRVSAhvareRNFTRDASHELRTPLTVIRVASDM---ALGDETLQP----------RLRRS 252
Cdd:PRK11073 110 PMDNQ---RRLSQEQLQHAQQVAA-----RDLVRGLAHEIKNPLGGLRGAAQLlskALPDPALTEytkviieqadRLRNL 181
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 253 LQRI---QRAGRDMEAVIDAflILAReadVEPQIELfDVNDIVRYEVDNANELlgnrpvsvhlhsegPVQLHAPPRVLQV 329
Cdd:PRK11073 182 VDRLlgpQRPGTHVTESIHK--VAER---VVQLVSL-ELPDNVRLIRDYDPSL--------------PELAHDPDQIEQV 241
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 330 VVsNLVRNACSYTDEG--------RIDVQV--------LNDRVVVRDTGIGMSAEALSRAFEPFYRAepsRPQGTGLGLS 393
Cdd:PRK11073 242 LL-NIVRNALQALGPEggtitlrtRTAFQLtlhgeryrLAARIDIEDNGPGIPPHLQDTLFYPMVSG---REGGTGLGLS 317
|
250 260
....*....|....*....|....*..
gi 503802029 394 IVRRLCDRFGWKVSLASEPGKgTEATV 420
Cdd:PRK11073 318 IARNLIDQHSGKIEFTSWPGH-TEFSV 343
|
|
| ComP |
COG4585 |
Signal transduction histidine kinase ComP [Signal transduction mechanisms]; |
192-422 |
4.66e-05 |
|
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
Pssm-ID: 443642 [Multi-domain] Cd Length: 252 Bit Score: 44.61 E-value: 4.66e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 192 ETRQLAAALHSLANRVSAHVARERN-FTRD----ASHELrtplTVIRVASDMALGDETLQP-RLRRSLQRIQRAGRDMEA 265
Cdd:COG4585 31 RAERAAELERELAARAEEAREEERRrIARElhdgVGQSL----SAIKLQLEAARRLLDADPeAAREELEEIRELAREALA 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 266 VIDAFLILAREADVEPqielFDVNDIVRYEVDNANELLGnrpVSVHLHSEGPVQLHAPPRVLQV--VVSNLVRNACSYTD 343
Cdd:COG4585 107 ELRRLVRGLRPPALDD----LGLAAALEELAERLLRAAG---IRVELDVDGDPDRLPPEVELALyrIVQEALTNALKHAG 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 344 EGRIDVQVLND----RVVVRDTGIGMsaealsrafepfyraEPSRPQGTGLGLSIVRRLCDRFGWKVSLASEPGKGTEAT 419
Cdd:COG4585 180 ATRVTVTLEVDdgelTLTVRDDGVGF---------------DPEAAPGGGLGLRGMRERAEALGGTLTIGSAPGGGTRVR 244
|
...
gi 503802029 420 VIF 422
Cdd:COG4585 245 ATL 247
|
|
| HATPase_RsbW-like |
cd16936 |
Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase ... |
327-404 |
4.21e-04 |
|
Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains; This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B.
Pssm-ID: 340413 [Multi-domain] Cd Length: 91 Bit Score: 39.17 E-value: 4.21e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 327 LQVVVSNLVRNACSYTD----EGRIDVQVLND----RVVVRDTGIGMsaeALSRAFEPfyraEPSRPQGtGLGLSIVRRL 398
Cdd:cd16936 1 VELAVSEAVTNAVRHAYrhdgPGPVRLELDLDpdrlRVEVTDSGPGF---DPLRPADP----DAGLREG-GRGLALIRAL 72
|
....*.
gi 503802029 399 CDRFGW 404
Cdd:cd16936 73 MDEVGY 78
|
|
| HATPase_UhpB-NarQ-NarX-like |
cd16917 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
325-420 |
1.04e-03 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains.
Pssm-ID: 340394 [Multi-domain] Cd Length: 87 Bit Score: 37.92 E-value: 1.04e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503802029 325 RVLQVVVSNLVRNAcsYTDEGRIDVQVLNDRVV--VRDTGIGmsaealsrafepfyRAEPSRPQGTGLGLSIVRRLCDRF 402
Cdd:cd16917 3 RIVQEALTNALKHA--GASRVRVTLSYTADELTltVVDDGVG--------------FDGPAPPGGGGFGLLGMRERAELL 66
|
90
....*....|....*...
gi 503802029 403 GWKVSLASEPGKGTEATV 420
Cdd:cd16917 67 GGTLTIGSRPGGGTRVTA 84
|
|
|