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Conserved domains on  [gi|503845262|ref|WP_014079256|]
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HPr family phosphocarrier protein [Roseburia hominis]

Protein Classification

HPr family phosphocarrier protein( domain architecture ID 10448849)

HPr family phosphocarrier protein is part of a phosphoenolpyruvate-dependent phosphotransferase (PTS)-like system that catalyzes the phosphorylation of incoming substrates with their concomitant translocation across the cell membrane

CATH:  3.30.1340.10
Gene Ontology:  GO:0009401
PubMed:  12405346
SCOP:  4001693

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PTS-HPr pfam00381
PTS HPr component phosphorylation site;
17-52 3.62e-04

PTS HPr component phosphorylation site;


:

Pssm-ID: 459792 [Multi-domain]  Cd Length: 79  Bit Score: 35.05  E-value: 3.62e-04
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 503845262  17 FVNAITQYEYDFDLISGRYVIDAKSIMGIFSLDLSK 52
Cdd:pfam00381 19 LVQLASKFDSDITLEKGGKKVNAKSIMGLMSLGAKQ 54
PTS-HPr_like super family cl00206
Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of ...
 2-75 6.55e-03

Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation across the cell membrane. The phosphoryl group from phosphoenolpyruvate is transferred to HPr by enzyme I (EI). Phospho-HPr then transfers the phosphoryl group to one of several sugar-specific phosphoprotein intermediates. The conserved histidine in the N-terminus of HPr serves as an acceptor for the phosphoryl group of EI. In addition to the phosphotransferase proteins HPr and E1, this family also includes the closely related Carbon Catabolite Repressor (CCR) proteins which use the same phosphorylation mechanism and interact with transcriptional regulators to control expression of genes coding for utilization of less favored carbon sources.


The actual alignment was detected with superfamily member PRK13782:

Pssm-ID: 469657 [Multi-domain]  Cd Length: 82  Bit Score: 32.06  E-value: 6.55e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 503845262  2 KTVQISLNSIDKVKS---FVNAITQYEYDFDLISGRYVIDAKSIMGIFSLDLSKPIDLAIHAE-NNMDEIMETLKPYL 75
Cdd:PRK13782  4 KRVEVSLKTGLQARPaalFVQEANRFHADIFIEKDGKKVNAKSIMGLMSLAIGTGSMITIITEgSDEEEALEALAAYV 81
 
Name Accession Description Interval E-value
PTS-HPr pfam00381
PTS HPr component phosphorylation site;
17-52 3.62e-04

PTS HPr component phosphorylation site;


Pssm-ID: 459792 [Multi-domain]  Cd Length: 79  Bit Score: 35.05  E-value: 3.62e-04
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 503845262  17 FVNAITQYEYDFDLISGRYVIDAKSIMGIFSLDLSK 52
Cdd:pfam00381 19 LVQLASKFDSDITLEKGGKKVNAKSIMGLMSLGAKQ 54
PtsH COG1925
HPr or related phosphotransfer protein [Signal transduction mechanisms, Carbohydrate transport ...
 17-52 1.93e-03

HPr or related phosphotransfer protein [Signal transduction mechanisms, Carbohydrate transport and metabolism];


Pssm-ID: 441528 [Multi-domain]  Cd Length: 88  Bit Score: 33.54  E-value: 1.93e-03
                        10        20        30
                ....*....|....*....|....*....|....*.
gi 503845262 17 FVNAITQYEYDFDLISGRYVIDAKSIMGIFSLDLSK 52
Cdd:COG1925  22 LVQLASKFDSEITVEKGGKEVNAKSIMGLMSLGAKK 57
PRK13782 PRK13782
HPr family phosphocarrier protein;
2-75 6.55e-03

HPr family phosphocarrier protein;


Pssm-ID: 172320 [Multi-domain]  Cd Length: 82  Bit Score: 32.06  E-value: 6.55e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 503845262  2 KTVQISLNSIDKVKS---FVNAITQYEYDFDLISGRYVIDAKSIMGIFSLDLSKPIDLAIHAE-NNMDEIMETLKPYL 75
Cdd:PRK13782  4 KRVEVSLKTGLQARPaalFVQEANRFHADIFIEKDGKKVNAKSIMGLMSLAIGTGSMITIITEgSDEEEALEALAAYV 81
PRK13780 PRK13780
phosphocarrier protein HPr; Provisional
 18-72 9.26e-03

phosphocarrier protein HPr; Provisional


Pssm-ID: 237503 [Multi-domain]  Cd Length: 88  Bit Score: 31.98  E-value: 9.26e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 503845262 18 VNAITQYEYDFDL-ISGRYViDAKSIMGIFSLDLSKPIDLAIHAENN-----MDEIMETLK 72
Cdd:PRK13780 23 VQTASKFDSDITLeYNGKSV-NLKSIMGVMSLGVGQGADITISAEGAdaadaIAAIEETMK 82
 
Name Accession Description Interval E-value
PTS-HPr pfam00381
PTS HPr component phosphorylation site;
17-52 3.62e-04

PTS HPr component phosphorylation site;


Pssm-ID: 459792 [Multi-domain]  Cd Length: 79  Bit Score: 35.05  E-value: 3.62e-04
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 503845262  17 FVNAITQYEYDFDLISGRYVIDAKSIMGIFSLDLSK 52
Cdd:pfam00381 19 LVQLASKFDSDITLEKGGKKVNAKSIMGLMSLGAKQ 54
PtsH COG1925
HPr or related phosphotransfer protein [Signal transduction mechanisms, Carbohydrate transport ...
 17-52 1.93e-03

HPr or related phosphotransfer protein [Signal transduction mechanisms, Carbohydrate transport and metabolism];


Pssm-ID: 441528 [Multi-domain]  Cd Length: 88  Bit Score: 33.54  E-value: 1.93e-03
                        10        20        30
                ....*....|....*....|....*....|....*.
gi 503845262 17 FVNAITQYEYDFDLISGRYVIDAKSIMGIFSLDLSK 52
Cdd:COG1925  22 LVQLASKFDSEITVEKGGKEVNAKSIMGLMSLGAKK 57
PRK13782 PRK13782
HPr family phosphocarrier protein;
2-75 6.55e-03

HPr family phosphocarrier protein;


Pssm-ID: 172320 [Multi-domain]  Cd Length: 82  Bit Score: 32.06  E-value: 6.55e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 503845262  2 KTVQISLNSIDKVKS---FVNAITQYEYDFDLISGRYVIDAKSIMGIFSLDLSKPIDLAIHAE-NNMDEIMETLKPYL 75
Cdd:PRK13782  4 KRVEVSLKTGLQARPaalFVQEANRFHADIFIEKDGKKVNAKSIMGLMSLAIGTGSMITIITEgSDEEEALEALAAYV 81
PRK13780 PRK13780
phosphocarrier protein HPr; Provisional
 18-72 9.26e-03

phosphocarrier protein HPr; Provisional


Pssm-ID: 237503 [Multi-domain]  Cd Length: 88  Bit Score: 31.98  E-value: 9.26e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 503845262 18 VNAITQYEYDFDL-ISGRYViDAKSIMGIFSLDLSKPIDLAIHAENN-----MDEIMETLK 72
Cdd:PRK13780 23 VQTASKFDSDITLeYNGKSV-NLKSIMGVMSLGVGQGADITISAEGAdaadaIAAIEETMK 82
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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