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Conserved domains on  [gi|503860771|ref|WP_014094765|]
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helix-turn-helix transcriptional regulator [Candidatus Arthromitus sp. SFB-rat-Yit]

Protein Classification

ArsR/SmtB family transcription factor( domain architecture ID 10001925)

ArsR (Arsenical Resistance Operon Repressor)/SmtB family transcription factor is a winged-helix-turn-helix transcriptional regulator that may be metal-sensing and modulate the expression of genes associated with metal homeostasis

Gene Ontology:  GO:0003700|GO:0006355|GO:0003677
PubMed:  10473770|28436329|12829264|28512703|30191942|15808743

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
2-90 4.19e-32

DNA-binding transcriptional regulator, ArsR family [Transcription];


:

Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 107.67  E-value: 4.19e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503860771   2 EILYSDVVKVFKALCDENRLKILEQLRVGEKCACDLLDYLCVTQSTLSHHMKLLCDADIVRARKDGKWVYYSINLDGVER 81
Cdd:COG0640    4 TKELEELAELFKALADPTRLRILRLLAEGELCVGELAEALGLSQSTVSHHLKVLREAGLVTSRREGRWVYYRLADEALAE 83


                 ....*....
gi 503860771  82 AKKLLDQQL 90
Cdd:COG0640   84 LLEWLLELL 92
 
Name Accession Description Interval E-value
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
2-90 4.19e-32

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 107.67  E-value: 4.19e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503860771   2 EILYSDVVKVFKALCDENRLKILEQLRVGEKCACDLLDYLCVTQSTLSHHMKLLCDADIVRARKDGKWVYYSINLDGVER 81
Cdd:COG0640    4 TKELEELAELFKALADPTRLRILRLLAEGELCVGELAEALGLSQSTVSHHLKVLREAGLVTSRREGRWVYYRLADEALAE 83


                 ....*....
gi 503860771  82 AKKLLDQQL 90
Cdd:COG0640   84 LLEWLLELL 92
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 8-82 3.88e-30

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 102.15  E-value: 3.88e-30
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 503860771   8 VVKVFKALCDENRLKILEQLRVGEKCACDLLDYLCVTQSTLSHHMKLLCDADIVRARKDGKWVYYSINLDGVERA 82
Cdd:NF033788   1 LAELFKALADPTRLRILELLAEGELCVCELAEALGLSQSAVSQHLKVLRDAGLVTSRREGRWVYYRLADEHVAEL 75
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 12-75 6.66e-21

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 78.88  E-value: 6.66e-21
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 503860771  12 FKALCDENRLKILEQLRVGEKCACDLLDYLCVTQSTLSHHMKLLCDADIVRARKDGKWVYYSIN 75
Cdd:cd00090    1 LKALSDPTRLRILRLLLEGPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESRREGRRVYYSLT 64
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
22-87 4.66e-19

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 74.17  E-value: 4.66e-19
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 503860771    22 KILEQLRVGEKCACDLLDYLCVTQSTLSHHMKLLCDADIVRARKDGKWVYYSINLDGVERAKKLLD 87
Cdd:smart00418   1 KILKLLAEGELCVCELAEILGLSQSTVSHHLKKLREAGLVESRREGKRVYYSLTDEKVADLLEELL 66
repress_SdpR NF033789
autorepressor SdpR family transcription factor; Transcription factors in the family of the ...
 11-76 3.13e-18

autorepressor SdpR family transcription factor; Transcription factors in the family of the sporulation delaying system autorepressor SdpR (of Bacillus subtilis) resemble metalloregulatory transcriptional repressors such as ArsR, SmtB, CadX, ZiaR, etc., but may lack the key metal-binding residues.


Pssm-ID: 411369 [Multi-domain]  Cd Length: 79  Bit Score: 72.06  E-value: 3.13e-18
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 503860771  11 VFKALCDENRLKILEQLRVGEKCACDLLDYLCVTQSTLSHHMKLLCDADIVRARKDGKWVYYSINL 76
Cdd:NF033789   1 TFKALSDPTRREILELLKEGDMTAGEIAEHFDMSKPSISHHLNILKQADLVTDERKGQFIYYSLNT 66
PRK10141 PRK10141
DNA-binding transcriptional repressor ArsR; Provisional
 9-74 3.86e-13

DNA-binding transcriptional repressor ArsR; Provisional


Pssm-ID: 236654  Cd Length: 117  Bit Score: 60.21  E-value: 3.86e-13
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 503860771   9 VKVFKALCDENRLKILEQLR-VGEKCACDLLDYLCVTQSTLSHHMKLLCDADIVRARKDGKWVYYSI 74
Cdd:PRK10141   7 LQLFKILSDETRLGIVLLLReSGELCVCDLCTALDQSQPKISRHLALLRESGLLLDRKQGKWVHYRL 73
HTH_5 pfam01022
Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding ...
 17-61 1.30e-11

Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding 'helix-turn-helix' motif. This family includes other proteins which are not included in the Prosite definition.


Pssm-ID: 425993 [Multi-domain]  Cd Length: 45  Bit Score: 54.37  E-value: 1.30e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 503860771   17 DENRLKILEQLRVGEKCACDLLDYLCVTQSTLSHHMKLLCDADIV 61
Cdd:pfam01022   1 DPTRLKILKLLAEGELCVCELAEELGLSQSTVSHHLKKLREAGLV 45
 
Name Accession Description Interval E-value
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
2-90 4.19e-32

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 107.67  E-value: 4.19e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503860771   2 EILYSDVVKVFKALCDENRLKILEQLRVGEKCACDLLDYLCVTQSTLSHHMKLLCDADIVRARKDGKWVYYSINLDGVER 81
Cdd:COG0640    4 TKELEELAELFKALADPTRLRILRLLAEGELCVGELAEALGLSQSTVSHHLKVLREAGLVTSRREGRWVYYRLADEALAE 83


                 ....*....
gi 503860771  82 AKKLLDQQL 90
Cdd:COG0640   84 LLEWLLELL 92
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 8-82 3.88e-30

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 102.15  E-value: 3.88e-30
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 503860771   8 VVKVFKALCDENRLKILEQLRVGEKCACDLLDYLCVTQSTLSHHMKLLCDADIVRARKDGKWVYYSINLDGVERA 82
Cdd:NF033788   1 LAELFKALADPTRLRILELLAEGELCVCELAEALGLSQSAVSQHLKVLRDAGLVTSRREGRWVYYRLADEHVAEL 75
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 12-75 6.66e-21

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 78.88  E-value: 6.66e-21
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 503860771  12 FKALCDENRLKILEQLRVGEKCACDLLDYLCVTQSTLSHHMKLLCDADIVRARKDGKWVYYSIN 75
Cdd:cd00090    1 LKALSDPTRLRILRLLLEGPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESRREGRRVYYSLT 64
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
22-87 4.66e-19

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 74.17  E-value: 4.66e-19
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 503860771    22 KILEQLRVGEKCACDLLDYLCVTQSTLSHHMKLLCDADIVRARKDGKWVYYSINLDGVERAKKLLD 87
Cdd:smart00418   1 KILKLLAEGELCVCELAEILGLSQSTVSHHLKKLREAGLVESRREGKRVYYSLTDEKVADLLEELL 66
repress_SdpR NF033789
autorepressor SdpR family transcription factor; Transcription factors in the family of the ...
 11-76 3.13e-18

autorepressor SdpR family transcription factor; Transcription factors in the family of the sporulation delaying system autorepressor SdpR (of Bacillus subtilis) resemble metalloregulatory transcriptional repressors such as ArsR, SmtB, CadX, ZiaR, etc., but may lack the key metal-binding residues.


Pssm-ID: 411369 [Multi-domain]  Cd Length: 79  Bit Score: 72.06  E-value: 3.13e-18
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 503860771  11 VFKALCDENRLKILEQLRVGEKCACDLLDYLCVTQSTLSHHMKLLCDADIVRARKDGKWVYYSINL 76
Cdd:NF033789   1 TFKALSDPTRREILELLKEGDMTAGEIAEHFDMSKPSISHHLNILKQADLVTDERKGQFIYYSLNT 66
PRK10141 PRK10141
DNA-binding transcriptional repressor ArsR; Provisional
 9-74 3.86e-13

DNA-binding transcriptional repressor ArsR; Provisional


Pssm-ID: 236654  Cd Length: 117  Bit Score: 60.21  E-value: 3.86e-13
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 503860771   9 VKVFKALCDENRLKILEQLR-VGEKCACDLLDYLCVTQSTLSHHMKLLCDADIVRARKDGKWVYYSI 74
Cdd:PRK10141   7 LQLFKILSDETRLGIVLLLReSGELCVCDLCTALDQSQPKISRHLALLRESGLLLDRKQGKWVHYRL 73
HTH_5 pfam01022
Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding ...
 17-61 1.30e-11

Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding 'helix-turn-helix' motif. This family includes other proteins which are not included in the Prosite definition.


Pssm-ID: 425993 [Multi-domain]  Cd Length: 45  Bit Score: 54.37  E-value: 1.30e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 503860771   17 DENRLKILEQLRVGEKCACDLLDYLCVTQSTLSHHMKLLCDADIV 61
Cdd:pfam01022   1 DPTRLKILKLLAEGELCVCELAEELGLSQSTVSHHLKKLREAGLV 45
COG4189 COG4189
Predicted transcriptional regulator, ArsR family [Transcription];
1-65 7.54e-11

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 443343 [Multi-domain]  Cd Length: 97  Bit Score: 53.81  E-value: 7.54e-11
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 503860771   1 MEILYSD-VVKVFKALCDENRLKILEQLRVGEKCACDLLDYLCVTQSTLSHHMKLLCDADIVRARK 65
Cdd:COG4189    1 MVVLDDEeSLEVLKALASETRLRILRLLAEEPLNVNELAEALGLPKSTVSYHIRKLEEAGLIRTEY 66
HTH_20 pfam12840
Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in ...
 10-68 6.39e-10

Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in transcriptional regulatory proteins.


Pssm-ID: 432824 [Multi-domain]  Cd Length: 61  Bit Score: 50.62  E-value: 6.39e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 503860771   10 KVFKALCDENRLKILEQLRVGEKCAC-DLLDYLCVTQSTLSHHMKLLCDADIVRARKDGK 68
Cdd:pfam12840   2 DVAEALADPTRLRILRALVGDEPLTAsELARRLDISRNTLSYHLRKLEEAGLVEVVREGR 61
COG3398 COG3398
Predicted transcriptional regulator, contains two HTH domains [Transcription];
10-75 2.93e-09

Predicted transcriptional regulator, contains two HTH domains [Transcription];


Pssm-ID: 442625 [Multi-domain]  Cd Length: 159  Bit Score: 51.03  E-value: 2.93e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 503860771  10 KVFKALCDENRLKILEQLRvGEKCAC--DLLDYLCVTQSTLSHHMKLLCDADIVRARKDGKWVYYSIN 75
Cdd:COG3398   89 KILAYLRRETPRRILLYLL-ENPGATnkELAEELGISRSTVSWHLKRLEEDGLVERERDGRNVRYYLN 155
COG4742 COG4742
Predicted transcriptional regulator, contains HTH domain [Transcription];
18-70 2.71e-05

Predicted transcriptional regulator, contains HTH domain [Transcription];


Pssm-ID: 443776 [Multi-domain]  Cd Length: 267  Bit Score: 41.03  E-value: 2.71e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 503860771  18 ENRLKILEQLRVGEKCACDLLDYLCVTQSTLSHHMKLLCDADIVRaRKDGKWV 70
Cdd:COG4742   16 EKRKNILLLLAEGPKTRSELAESLDVSRSTILRQLKELEERGLIE-RDDGEYE 67
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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