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Conserved domains on  [gi|503961923|ref|WP_014195917|]
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MULTISPECIES: carboxylesterase [Geobacillus]

Protein Classification

alpha/beta hydrolase( domain architecture ID 10787854)

alpha/beta hydrolase family protein catalyzes the hydrolysis of substrates with different chemical composition or physicochemical properties using a nucleophile-His-acid catalytic triad

CATH:  3.40.50.1820
EC:  3.-.-.-
Gene Ontology:  GO:0016787
PubMed:  19508187|12369917|37582413

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
YvaK COG1647
Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];
9-250 2.92e-108

Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];


:

Pssm-ID: 441253 [Multi-domain]  Cd Length: 246  Bit Score: 312.26  E-value: 2.92e-108
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503961923   9 SGAEPFYAENGPVGVLLVHGFTGTPHSMRPLAEAYAKAGYTVCLPRLKGHGTHYEDMERTTFHDWVASVEEGYGWLKQRC 88
Cdd:COG1647    4 LGAEPFFLEGGRKGVLLLHGFTGSPAEMRPLAEALAKAGYTVYAPRLPGHGTSPEDLLKTTWEDWLEDVEEAYEILKAGY 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503961923  89 QTIFVTGLSMGGTLTLYLAEHHPDICGIVPINAAVDIPAIAAGMTG-GGELPRYLDSIGSDLKNPDVKELAYEKTPTASL 167
Cdd:COG1647   84 DKVIVIGLSMGGLLALLLAARYPDVAGLVLLSPALKIDDPSAPLLPlLKYLARSLRGIGSDIEDPEVAEYAYDRTPLRAL 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503961923 168 LQLARLMAQTKAKLDRIVCPALIFVSDEDHVVPPGNADIIFQGISSTEKEIVRLRNSYHVATLDYDQPMIIERSLEFFAK 247
Cdd:COG1647  164 AELQRLIREVRRDLPKITAPTLIIQSRKDEVVPPESARYIYERLGSPDKELVWLEDSGHVITLDKDREEVAEEILDFLER 243


                 ...
gi 503961923 248 HAG 250
Cdd:COG1647  244 LAA 246
 
Name Accession Description Interval E-value
YvaK COG1647
Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];
9-250 2.92e-108

Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 441253 [Multi-domain]  Cd Length: 246  Bit Score: 312.26  E-value: 2.92e-108
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503961923   9 SGAEPFYAENGPVGVLLVHGFTGTPHSMRPLAEAYAKAGYTVCLPRLKGHGTHYEDMERTTFHDWVASVEEGYGWLKQRC 88
Cdd:COG1647    4 LGAEPFFLEGGRKGVLLLHGFTGSPAEMRPLAEALAKAGYTVYAPRLPGHGTSPEDLLKTTWEDWLEDVEEAYEILKAGY 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503961923  89 QTIFVTGLSMGGTLTLYLAEHHPDICGIVPINAAVDIPAIAAGMTG-GGELPRYLDSIGSDLKNPDVKELAYEKTPTASL 167
Cdd:COG1647   84 DKVIVIGLSMGGLLALLLAARYPDVAGLVLLSPALKIDDPSAPLLPlLKYLARSLRGIGSDIEDPEVAEYAYDRTPLRAL 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503961923 168 LQLARLMAQTKAKLDRIVCPALIFVSDEDHVVPPGNADIIFQGISSTEKEIVRLRNSYHVATLDYDQPMIIERSLEFFAK 247
Cdd:COG1647  164 AELQRLIREVRRDLPKITAPTLIIQSRKDEVVPPESARYIYERLGSPDKELVWLEDSGHVITLDKDREEVAEEILDFLER 243


                 ...
gi 503961923 248 HAG 250
Cdd:COG1647  244 LAA 246
Hydrolase_4 pfam12146
Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is ...
 23-226 5.47e-20

Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is approximately 110 amino acids in length. It is found in association with pfam00561. The majority of the members in this family carry the exopeptidase active-site residues of Ser-122, Asp-239 and His-269 as in UniProtKB:Q7ZWC2.


Pssm-ID: 463473 [Multi-domain]  Cd Length: 238  Bit Score: 85.34  E-value: 5.47e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503961923   23 VLLVHGFTGtpHSMR--PLAEAYAKAGYTVCLPRLKGHGthYEDMER---TTFHDWVASVEEGYGWLKQR--CQTIFVTG 95
Cdd:pfam12146   7 VVLVHGLGE--HSGRyaHLADALAAQGFAVYAYDHRGHG--RSDGKRghvPSFDDYVDDLDTFVDKIREEhpGLPLFLLG 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503961923   96 LSMGGTL-TLYLAEHHPDICGIVPINAAVDI-----PAIAAGMTG--GGELPRYLDSIGSDLK----NPDVKELAYE--- 160
Cdd:pfam12146  83 HSMGGLIaALYALRYPDKVDGLILSAPALKIkpylaPPILKLLAKllGKLFPRLRVPNNLLPDslsrDPEVVAAYAAdpl 162

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 503961923  161 ---KTPTASLLQLARLMAQTKAKLDRIVCPALIFVSDEDHVVPPGNADIIFQGISSTEKEIVRLRNSYH 226
Cdd:pfam12146 163 vhgGISARTLYELLDAGERLLRRAAAITVPLLLLHGGADRVVDPAGSREFYERAGSTDKTLKLYPGLYH 231
hydr2_PEP TIGR03101
exosortase A system-associated hydrolase 2; This group of proteins are members of the alpha ...
 18-114 4.56e-05

exosortase A system-associated hydrolase 2; This group of proteins are members of the alpha/beta hydrolase superfamily. These proteins are generally found in genomes containing the exosortase/PEP-CTERM protein expoert system, specifically the type 1 variant of this system described by the Genome Property GenProp0652. When found in this context they are invariably present in the vicinity of a second, relatively unrelated enzyme (ortholog 1, TIGR03100) of the same superfamily.


Pssm-ID: 274428  Cd Length: 266  Bit Score: 43.65  E-value: 4.56e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503961923   18 NGPVGVLL-VHGF----TGTPHSMRPLAEAYAKAGYTVCLPRLKGHGTHYEDMERTTFHDWVASVEEGYGWLKQR-CQTI 91
Cdd:TIGR03101  22 VGPRGVVIyLPPFaeemNKSRRMVALQARAFAAGGFGVLQIDLYGCGDSAGDFAAARWDVWKEDVAAAYRWLIEQgHPPV 101

                          90       100
                  ....*....|....*....|...
gi 503961923   92 FVTGLSMGGTLTLYLAEHHPDIC 114
Cdd:TIGR03101 102 TLWGLRLGALLALDAANPLAAKC 124
PRK14875 PRK14875
acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional
 15-112 7.16e-05

acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional


Pssm-ID: 184875 [Multi-domain]  Cd Length: 371  Bit Score: 43.39  E-value: 7.16e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503961923  15 YAENGPVG---VLLVHGFTGTPHSMRPLAEAYAkAGYTVCLPRLKGHGTHYEDMERTTFHDWVASVEegyGWLKQ----R 87
Cdd:PRK14875 123 YLRLGEGDgtpVVLIHGFGGDLNNWLFNHAALA-AGRPVIALDLPGHGASSKAVGAGSLDELAAAVL---AFLDAlgieR 198

                         90       100
                 ....*....|....*....|....*
gi 503961923  88 CQtifVTGLSMGGTLTLYLAEHHPD 112
Cdd:PRK14875 199 AH---LVGHSMGGAVALRLAARAPQ 220
 
Name Accession Description Interval E-value
YvaK COG1647
Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];
9-250 2.92e-108

Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 441253 [Multi-domain]  Cd Length: 246  Bit Score: 312.26  E-value: 2.92e-108
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503961923   9 SGAEPFYAENGPVGVLLVHGFTGTPHSMRPLAEAYAKAGYTVCLPRLKGHGTHYEDMERTTFHDWVASVEEGYGWLKQRC 88
Cdd:COG1647    4 LGAEPFFLEGGRKGVLLLHGFTGSPAEMRPLAEALAKAGYTVYAPRLPGHGTSPEDLLKTTWEDWLEDVEEAYEILKAGY 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503961923  89 QTIFVTGLSMGGTLTLYLAEHHPDICGIVPINAAVDIPAIAAGMTG-GGELPRYLDSIGSDLKNPDVKELAYEKTPTASL 167
Cdd:COG1647   84 DKVIVIGLSMGGLLALLLAARYPDVAGLVLLSPALKIDDPSAPLLPlLKYLARSLRGIGSDIEDPEVAEYAYDRTPLRAL 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503961923 168 LQLARLMAQTKAKLDRIVCPALIFVSDEDHVVPPGNADIIFQGISSTEKEIVRLRNSYHVATLDYDQPMIIERSLEFFAK 247
Cdd:COG1647  164 AELQRLIREVRRDLPKITAPTLIIQSRKDEVVPPESARYIYERLGSPDKELVWLEDSGHVITLDKDREEVAEEILDFLER 243


                 ...
gi 503961923 248 HAG 250
Cdd:COG1647  244 LAA 246
PldB COG2267
Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];
14-247 1.29e-23

Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];


Pssm-ID: 441868 [Multi-domain]  Cd Length: 221  Bit Score: 94.68  E-value: 1.29e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503961923  14 FYAENGPVG-VLLVHGFTGTPHSMRPLAEAYAKAGYTVCLPRLKGHG-THYEDMERTTFHDWVASVEEGYGWLKQRCQT- 90
Cdd:COG2267   21 WRPAGSPRGtVVLVHGLGEHSGRYAELAEALAAAGYAVLAFDLRGHGrSDGPRGHVDSFDDYVDDLRAALDALRARPGLp 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503961923  91 IFVTGLSMGGTLTLYLAEHHPDicgivPINAAVdipAIAagmtgggelPRYLDsigsdlkNPDVkelayekTPTASLLQL 170
Cdd:COG2267  101 VVLLGHSMGGLIALLYAARYPD-----RVAGLV---LLA---------PAYRA-------DPLL-------GPSARWLRA 149

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 503961923 171 ARLMAQtkakLDRIVCPALIFVSDEDHVVPPGNADIIFQGIsSTEKEIVRLRNSYHVATLDYDQPMIIERSLEFFAK 247
Cdd:COG2267  150 LRLAEA----LARIDVPVLVLHGGADRVVPPEAARRLAARL-SPDVELVLLPGARHELLNEPAREEVLAAILAWLER 221
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
23-248 9.30e-23

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 92.77  E-value: 9.30e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503961923  23 VLLVHGFTGTP-HSMRPLAEAYAKAGYTVCLPRLKGHGTHYEDMERTTFHDWVASVEegygWLKQRCQT----IFVTGLS 97
Cdd:COG1506   26 VVYVHGGPGSRdDSFLPLAQALASRGYAVLAPDYRGYGESAGDWGGDEVDDVLAAID----YLAARPYVdpdrIGIYGHS 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503961923  98 MGGTLTLYLAEHHPDIcgivpINAAVDIPAIAAGMTGGGELPRYLDSIgsdLKNPDVKELAYEKtptASLLQLArlmaqt 177
Cdd:COG1506  102 YGGYMALLAAARHPDR-----FKAAVALAGVSDLRSYYGTTREYTERL---MGGPWEDPEAYAA---RSPLAYA------ 164

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 503961923 178 kaklDRIVCPALIFVSDEDHVVPPGNADIIFQGISST--EKEIVRLRNSYHVATlDYDQPMIIERSLEFFAKH 248
Cdd:COG1506  165 ----DKLKTPLLLIHGEADDRVPPEQAERLYEALKKAgkPVELLVYPGEGHGFS-GAGAPDYLERILDFLDRH 232
FrsA COG1073
Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms]; ...
 23-248 3.42e-20

Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms];


Pssm-ID: 440691 [Multi-domain]  Cd Length: 253  Bit Score: 86.51  E-value: 3.42e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503961923  23 VLLVHGFTGTPHSMRPLAEAYAKAGYTVCLPRLKGHG------THYEDMERTTFHDWVAsveegygWLKQRCQT----IF 92
Cdd:COG1073   40 VVVAHGNGGVKEQRALYAQRLAELGFNVLAFDYRGYGesegepREEGSPERRDARAAVD-------YLRTLPGVdperIG 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503961923  93 VTGLSMGGTLTLYLAEHHPDICGIVPINAAVDIPAIAAGMTGGGELPRYldsigsdlknPDVkelAYekTPTASLLQLAR 172
Cdd:COG1073  113 LLGISLGGGYALNAAATDPRVKAVILDSPFTSLEDLAAQRAKEARGAYL----------PGV---PY--LPNVRLASLLN 177

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 503961923 173 LMAQTKAKLDRIVCPALIFVSDEDHVVPPGNADIIFQGISStEKEIVRLRNSYHVATLDYDQPMIIERSLEFFAKH 248
Cdd:COG1073  178 DEFDPLAKIEKISRPLLFIHGEKDEAVPFYMSEDLYEAAAE-PKELLIVPGAGHVDLYDRPEEEYFDKLAEFFKKN 252
Hydrolase_4 pfam12146
Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is ...
 23-226 5.47e-20

Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is approximately 110 amino acids in length. It is found in association with pfam00561. The majority of the members in this family carry the exopeptidase active-site residues of Ser-122, Asp-239 and His-269 as in UniProtKB:Q7ZWC2.


Pssm-ID: 463473 [Multi-domain]  Cd Length: 238  Bit Score: 85.34  E-value: 5.47e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503961923   23 VLLVHGFTGtpHSMR--PLAEAYAKAGYTVCLPRLKGHGthYEDMER---TTFHDWVASVEEGYGWLKQR--CQTIFVTG 95
Cdd:pfam12146   7 VVLVHGLGE--HSGRyaHLADALAAQGFAVYAYDHRGHG--RSDGKRghvPSFDDYVDDLDTFVDKIREEhpGLPLFLLG 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503961923   96 LSMGGTL-TLYLAEHHPDICGIVPINAAVDI-----PAIAAGMTG--GGELPRYLDSIGSDLK----NPDVKELAYE--- 160
Cdd:pfam12146  83 HSMGGLIaALYALRYPDKVDGLILSAPALKIkpylaPPILKLLAKllGKLFPRLRVPNNLLPDslsrDPEVVAAYAAdpl 162

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 503961923  161 ---KTPTASLLQLARLMAQTKAKLDRIVCPALIFVSDEDHVVPPGNADIIFQGISSTEKEIVRLRNSYH 226
Cdd:pfam12146 163 vhgGISARTLYELLDAGERLLRRAAAITVPLLLLHGGADRVVDPAGSREFYERAGSTDKTLKLYPGLYH 231
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 1-248 5.11e-18

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 79.66  E-value: 5.11e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503961923   1 MSEQYPVLSGAEPFYAENGPVG--VLLVHGFTGTPHSMRPLAEAYAkAGYTVCLPRLKGHGTHYEDMERTTFHDWVASVE 78
Cdd:COG0596    2 STPRFVTVDGVRLHYREAGPDGppVVLLHGLPGSSYEWRPLIPALA-AGYRVIAPDLRGHGRSDKPAGGYTLDDLADDLA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503961923  79 E-----GYGwlkqrcQTIFVtGLSMGGTLTLYLAEHHPD-ICGIVPINAAVDipAIAAGMTGGGELPRYLDSIGSDLKNP 152
Cdd:COG0596   81 AlldalGLE------RVVLV-GHSMGGMVALELAARHPErVAGLVLVDEVLA--ALAEPLRRPGLAPEALAALLRALART 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503961923 153 DVKELayektptasllqlarlmaqtkakLDRIVCPALIFVSDEDHVVPPGNADIIFQGISSTekEIVRLRNSYHVATLdy 232
Cdd:COG0596  152 DLRER-----------------------LARITVPTLVIWGEKDPIVPPALARRLAELLPNA--ELVVLPGAGHFPPL-- 204

                        250
                 ....*....|....*..
gi 503961923 233 DQP-MIIERSLEFFAKH 248
Cdd:COG0596  205 EQPeAFAAALRDFLARL 221
DLH COG0412
Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism];
22-246 2.76e-12

Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440181 [Multi-domain]  Cd Length: 226  Bit Score: 64.22  E-value: 2.76e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503961923  22 GVLLVHGFTGTPHSMRPLAEAYAKAGYTVCLPRLKGHGTHYED-------MERTTFHDWVASVEEGYGWLKQRCQT---- 90
Cdd:COG0412   31 GVVVLHEIFGLNPHIRDVARRLAAAGYVVLAPDLYGRGGPGDDpdearalMGALDPELLAADLRAALDWLKAQPEVdagr 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503961923  91 IFVTGLSMGGTLTLYLAEHHPDICGIVPINaavdipaiaagmtGGGelpryldsigsdlknpdvkelayektPTASLLQL 170
Cdd:COG0412  111 VGVVGFCFGGGLALLAAARGPDLAAAVSFY-------------GGL--------------------------PADDLLDL 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503961923 171 ARlmaqtkakldRIVCPALIFVSDEDHVVPPGNADIIFQGISS--TEKEIVRLRNSYHVATLD----YDQP---MIIERS 241
Cdd:COG0412  152 AA----------RIKAPVLLLYGEKDPLVPPEQVAALEAALAAagVDVELHVYPGAGHGFTNPgrprYDPAaaeDAWQRT 221


                 ....*
gi 503961923 242 LEFFA 246
Cdd:COG0412  222 LAFLA 226
Abhydrolase_1 pfam00561
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
 23-228 8.56e-12

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 395444 [Multi-domain]  Cd Length: 245  Bit Score: 62.91  E-value: 8.56e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503961923   23 VLLVHGFTGTPHSMRPLAEAYAKAGYTVCLPRLKGHG-----THYEDMERTTFHDWVASVEEGYGWlkqrcQTIFVTGLS 97
Cdd:pfam00561   3 VLLLHGLPGSSDLWRKLAPALARDGFRVIALDLRGFGkssrpKAQDDYRTDDLAEDLEYILEALGL-----EKVNLVGHS 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503961923   98 MGGTLTLYLAEHHPDIC------GIVPINAAVDIPAIAAGMTGGGELPRYLDSIGSDLKNPDV-KELAYEKTPTASLLQL 170
Cdd:pfam00561  78 MGGLIALAYAAKYPDRVkalvllGALDPPHELDEADRFILALFPGFFDGFVADFAPNPLGRLVaKLLALLLLRLRLLKAL 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503961923  171 ARLMAQTK---------------------------AKLDRIVCPALIFVSDEDHVVPPGNADIIFQGISSTEKeiVRLRN 223
Cdd:pfam00561 158 PLLNKRFPsgdyalakslvtgallfietwstelraKFLGRLDEPTLIIWGDQDPLVPPQALEKLAQLFPNARL--VVIPD 235


                  ....*
gi 503961923  224 SYHVA 228
Cdd:pfam00561 236 AGHFA 240
COG4188 COG4188
Predicted dienelactone hydrolase [General function prediction only];
5-231 3.25e-11

Predicted dienelactone hydrolase [General function prediction only];


Pssm-ID: 443342 [Multi-domain]  Cd Length: 326  Bit Score: 62.05  E-value: 3.25e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503961923   5 YPVLSGAEPFYAENGPVgVLLVHGFTGTPHSMRPLAEAYAKAGYTVCLPRlkgH-GTHYEDMERTTFHDWVASVEEgygW 83
Cdd:COG4188   48 YPATAPADAPAGGPFPL-VVLSHGLGGSREGYAYLAEHLASHGYVVAAPD---HpGSNAADLSAALDGLADALDPE---E 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503961923  84 LKQRC--------------------------QTIFVTGLSMGGTLTLYLAEHHPDICGIVPINAAVDIPAIAAgmtggGE 137
Cdd:COG4188  121 LWERPldlsfvldqllalnksdpplagrldlDRIGVIGHSLGGYTALALAGARLDFAALRQYCGKNPDLQCRA-----LD 195

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503961923 138 LPRyldsIGSDLKNPDVKelayektpTASLLQLARLMAQTKAKLDRIVCPALIFVSDEDHVVPPG-NADIIFQGISSTEK 216
Cdd:COG4188  196 LPR----LAYDLRDPRIK--------AVVALAPGGSGLFGEEGLAAITIPVLLVAGSADDVTPAPdEQIRPFDLLPGADK 263

                        250
                 ....*....|....*
gi 503961923 217 EIVRLRNSYHVATLD 231
Cdd:COG4188  264 YLLTLEGATHFSFLD 278
Abhydrolase_6 pfam12697
Alpha/beta hydrolase family; This family contains alpha/beta hydrolase enzymes of diverse ...
 23-234 5.94e-10

Alpha/beta hydrolase family; This family contains alpha/beta hydrolase enzymes of diverse specificity.


Pssm-ID: 463673 [Multi-domain]  Cd Length: 211  Bit Score: 57.48  E-value: 5.94e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503961923   23 VLLVHGFtgtPHSMRPLAEAYAkAGYTVCLPRLKGHGThyEDMERTTFHDwVASVEEGYGWLKQRCQTIFVtGLSMGGTL 102
Cdd:pfam12697   1 VVLVHGA---GLSAAPLAALLA-AGVAVLAPDLPGHGS--SSPPPLDLAD-LADLAALLDELGAARPVVLV-GHSLGGAV 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503961923  103 TLYLAEHHPDIC-----GIVPINAAVDIPAIAAGMTGGGELPRYL--DSIGSDLKNPDVKELAYEKTPTASLLQLARLMA 175
Cdd:pfam12697  73 ALAAAAAALVVGvlvapLAAPPGLLAALLALLARLGAALAAPAWLaaESLARGFLDDLPADAEWAAALARLAALLAALAL 152

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 503961923  176 QTKAKLDRIVCPALIfVSDEDHVVPPGNADIIfqgISSTEKEIVRLRNSYHVATLDYDQ 234
Cdd:pfam12697 153 LPLAAWRDLPVPVLV-LAEEDRLVPELAQRLL---AALAGARLVVLPGAGHLPLDDPEE 207
EstA COG1075
Triacylglycerol esterase/lipase EstA, alpha/beta hydrolase fold [Lipid transport and ...
 23-110 2.35e-08

Triacylglycerol esterase/lipase EstA, alpha/beta hydrolase fold [Lipid transport and metabolism];


Pssm-ID: 440693 [Multi-domain]  Cd Length: 106  Bit Score: 50.60  E-value: 2.35e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503961923  23 VLLVHGFTGTPHSMRPLAEAYAKAGYTVCLPRLKGHGTHYEDMERtTFHDWVASVEEGYGwlkqRCQTIFVtGLSMGGTL 102
Cdd:COG1075    8 VVLVHGLGGSAASWAPLAPRLRAAGYPVYALNYPSTNGSIEDSAE-QLAAFVDAVLAATG----AEKVDLV-GHSMGGLV 81


                 ....*...
gi 503961923 103 TLYLAEHH 110
Cdd:COG1075   82 ARYYLKRL 89
YheT COG0429
Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only];
23-127 2.66e-08

Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only];


Pssm-ID: 440198 [Multi-domain]  Cd Length: 323  Bit Score: 53.61  E-value: 2.66e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503961923  23 VLLVHGFTGTPHS--MRPLAEAYAKAGYTVCLPRLKGHGthyEDMER--TTFH-------DWVAsveegyGWLKQRC--Q 89
Cdd:COG0429   64 VVLLHGLEGSSDShyARGLARALYARGWDVVRLNFRGCG---GEPNLlpRLYHsgdtedlVWVL------AHLRARYpyA 134

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 503961923  90 TIFVTGLSMGGTLTL-YLAEH---HPDICGIVPINAAVDIPA 127
Cdd:COG0429  135 PLYAVGFSLGGNLLLkYLGEQgddAPPLKAAVAVSPPLDLAA 176
YpfH COG0400
Predicted esterase [General function prediction only];
23-115 1.90e-07

Predicted esterase [General function prediction only];


Pssm-ID: 440169 [Multi-domain]  Cd Length: 200  Bit Score: 49.91  E-value: 1.90e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503961923  23 VLLVHGFTGTPHSMRPLAEAYAKAGYTVCLPR--------------LKGHGTHY--EDMERTT--FHDWVASVEEGYGWL 84
Cdd:COG0400    8 VVLLHGYGGDEEDLLPLAPELALPGAAVLAPRapvpegpggrawfdLSFLEGREdeEGLAAAAeaLAAFIDELEARYGID 87

                         90       100       110
                 ....*....|....*....|....*....|.
gi 503961923  85 KQRcqtIFVTGLSMGGTLTLYLAEHHPDICG 115
Cdd:COG0400   88 PER---IVLAGFSQGAAMALSLALRRPELLA 115
Aes COG0657
Acetyl esterase/lipase [Lipid transport and metabolism];
16-127 2.13e-06

Acetyl esterase/lipase [Lipid transport and metabolism];


Pssm-ID: 440422 [Multi-domain]  Cd Length: 207  Bit Score: 47.18  E-value: 2.13e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503961923  16 AENGPVgVLLVHG---FTGTPHSMRPLAEAYAK-AGYTVCLP--RLKGHGTH---YEDMERTTfhDWVASVEEGYGWLKQ 86
Cdd:COG0657   10 KGPLPV-VVYFHGggwVSGSKDTHDPLARRLAArAGAAVVSVdyRLAPEHPFpaaLEDAYAAL--RWLRANAAELGIDPD 86

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 503961923  87 RcqtIFVTGLSMGGTLTLYLA-----EHHPDICGIVPINAAVDIPA 127
Cdd:COG0657   87 R---IAVAGDSAGGHLAAALAlrardRGGPRPAAQVLIYPVLDLTA 129
COG4099 COG4099
Predicted peptidase [General function prediction only];
91-130 5.58e-06

Predicted peptidase [General function prediction only];


Pssm-ID: 443275 [Multi-domain]  Cd Length: 235  Bit Score: 46.11  E-value: 5.58e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 503961923  91 IFVTGLSMGGTLTLYLAEHHPD-ICGIVPINAAVDIPAIAA 130
Cdd:COG4099  127 IYLTGLSMGGYGTWDLAARYPDlFAAAVPICGGGDPANAAN 167
FrmB COG0627
S-formylglutathione hydrolase FrmB [Defense mechanisms];
16-112 4.36e-05

S-formylglutathione hydrolase FrmB [Defense mechanisms];


Pssm-ID: 440392 [Multi-domain]  Cd Length: 249  Bit Score: 43.67  E-value: 4.36e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503961923  16 AENGPVGVL-LVHGFTGTPHS--MRPLAEAYA-------------KAGYtvCLPRLKGHGTHYeDMErtTFHdwvasVEE 79
Cdd:COG0627   28 YDGRPLPVLyLLHGLTGTHENwtRKTGAQRLAaelgvivvmpdggQASF--YVDWTQGPAGHY-RWE--TYL-----TEE 97

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 503961923  80 GYGWLKQRCQTI------FVTGLSMGGTLTLYLAEHHPD 112
Cdd:COG0627   98 LPPLIEANFPVSadrerrAIAGLSMGGHGALTLALRHPD 136
hydr2_PEP TIGR03101
exosortase A system-associated hydrolase 2; This group of proteins are members of the alpha ...
 18-114 4.56e-05

exosortase A system-associated hydrolase 2; This group of proteins are members of the alpha/beta hydrolase superfamily. These proteins are generally found in genomes containing the exosortase/PEP-CTERM protein expoert system, specifically the type 1 variant of this system described by the Genome Property GenProp0652. When found in this context they are invariably present in the vicinity of a second, relatively unrelated enzyme (ortholog 1, TIGR03100) of the same superfamily.


Pssm-ID: 274428  Cd Length: 266  Bit Score: 43.65  E-value: 4.56e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503961923   18 NGPVGVLL-VHGF----TGTPHSMRPLAEAYAKAGYTVCLPRLKGHGTHYEDMERTTFHDWVASVEEGYGWLKQR-CQTI 91
Cdd:TIGR03101  22 VGPRGVVIyLPPFaeemNKSRRMVALQARAFAAGGFGVLQIDLYGCGDSAGDFAAARWDVWKEDVAAAYRWLIEQgHPPV 101

                          90       100
                  ....*....|....*....|...
gi 503961923   92 FVTGLSMGGTLTLYLAEHHPDIC 114
Cdd:TIGR03101 102 TLWGLRLGALLALDAANPLAAKC 124
PRK14875 PRK14875
acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional
 15-112 7.16e-05

acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional


Pssm-ID: 184875 [Multi-domain]  Cd Length: 371  Bit Score: 43.39  E-value: 7.16e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503961923  15 YAENGPVG---VLLVHGFTGTPHSMRPLAEAYAkAGYTVCLPRLKGHGTHYEDMERTTFHDWVASVEegyGWLKQ----R 87
Cdd:PRK14875 123 YLRLGEGDgtpVVLIHGFGGDLNNWLFNHAALA-AGRPVIALDLPGHGASSKAVGAGSLDELAAAVL---AFLDAlgieR 198

                         90       100
                 ....*....|....*....|....*
gi 503961923  88 CQtifVTGLSMGGTLTLYLAEHHPD 112
Cdd:PRK14875 199 AH---LVGHSMGGAVALRLAARAPQ 220
LpqC COG3509
Acetyl xylan esterase AxeA and related esterases, LpqC family [Carbohydrate transport and ...
 15-119 1.12e-04

Acetyl xylan esterase AxeA and related esterases, LpqC family [Carbohydrate transport and metabolism];


Pssm-ID: 442732 [Multi-domain]  Cd Length: 284  Bit Score: 42.30  E-value: 1.12e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503961923  15 YAENGPVGVLLV-HGFTGTPHS------MRPLAEAYakaGYTVCLPR-LKGHGTHY------EDMERTT-----FHDWVA 75
Cdd:COG3509   47 YDGGAPLPLVVAlHGCGGSAADfaagtgLNALADRE---GFIVVYPEgTGRAPGRCwnwfdgRDQRRGRddvafIAALVD 123

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 503961923  76 SVEEGYGWLKQRcqtIFVTGLSMGGTLTLYLAEHHPD-ICGIVPI 119
Cdd:COG3509  124 DLAARYGIDPKR---VYVTGLSAGGAMAYRLACEYPDvFAAVAPV 165
PRK10566 PRK10566
esterase; Provisional
 23-202 2.06e-04

esterase; Provisional


Pssm-ID: 182555 [Multi-domain]  Cd Length: 249  Bit Score: 41.51  E-value: 2.06e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503961923  23 VLLVHGFTGTPHSMRPLAEAYAKAGYTVCLPRLKGHGTHYE-DMERTTFHDW---------VASVEEGY---GWLKQrcQ 89
Cdd:PRK10566  30 VFFYHGFTSSKLVYSYFAVALAQAGFRVIMPDAPMHGARFSgDEARRLNHFWqillqnmqeFPTLRAAIreeGWLLD--D 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503961923  90 TIFVTGLSMGGTLTLYLAEHHPDIcgivpinaavdipAIAAGMTGGGelprYLDSIGSDLKNP-DVKELAYEKTPTASLL 168
Cdd:PRK10566 108 RLAVGGASMGGMTALGIMARHPWV-------------KCVASLMGSG----YFTSLARTLFPPlIPETAAQQAEFNNIVA 170

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 503961923 169 QLARLMAQTK-AKL-DRivcPALIFVSDEDHVVPPG 202
Cdd:PRK10566 171 PLAEWEVTHQlEQLaDR---PLLLWHGLADDVVPAA 203
BAAT_C pfam08840
BAAT / Acyl-CoA thioester hydrolase C terminal; This catalytic domain is found at the C ...
 78-200 2.97e-04

BAAT / Acyl-CoA thioester hydrolase C terminal; This catalytic domain is found at the C terminal of acyl-CoA thioester hydrolases and bile acid-CoA:amino acid N-acetyltransferases (BAAT).


Pssm-ID: 430252 [Multi-domain]  Cd Length: 211  Bit Score: 40.73  E-value: 2.97e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503961923   78 EEGYGWLKQRCQT----IFVTGLSMGGTLTLYLAEHHPDICGIVPINAAVDIPaIAAGMTGGGELPRYLDSIGSDLKNPD 153
Cdd:pfam08840   7 EEAINYLLRHPKVkgpgIGLLGISKGGELALSMATFLKQITATVSINGSAVVS-GDPLVYKDNPLPPLGEGMRRIKVNKD 85

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 503961923  154 -VKELAYEKTPTASLLQLarlmaQTKAKLDRIVCPALIFVSDEDHVVP 200
Cdd:pfam08840  86 gLLDIRDMFNDPLSKPDP-----KSLIPVERAKGPFLFVVGQDDHNWP 128
Axe1 COG3458
Cephalosporin-C deacetylase or related acetyl esterase [Secondary metabolites biosynthesis, ...
 89-248 1.14e-03

Cephalosporin-C deacetylase or related acetyl esterase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 442681 [Multi-domain]  Cd Length: 318  Bit Score: 39.40  E-value: 1.14e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503961923  89 QTIFVTGLSMGGTLTLYLAEHHPDICGIVPINAAV-DIP-AIAAGMTGGG-ELPRYLDSIGSdlKNPDVKE-LAYektpt 164
Cdd:COG3458  176 KRIGVTGGSQGGGLALAAAALDPRVKAAAADVPFLcDFRrALELGRAGPYpEIRRYLRRHRE--REPEVFEtLSY----- 248

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503961923 165 asllqlarLMAQTKAKldRIVCPALIFVSDEDHVVPPGNADIIFQGISStEKEIVRLRNSYHvatlDYDQPMIIERSLEF 244
Cdd:COG3458  249 --------FDAVNFAR--RIKAPVLFSVGLMDPVCPPSTVFAAYNALAG-PKEILVYPFNGH----EGGGPEQQDRQLAF 313


                 ....
gi 503961923 245 FAKH 248
Cdd:COG3458  314 LREL 317
Peptidase_S9 pfam00326
Prolyl oligopeptidase family;
44-250 3.23e-03

Prolyl oligopeptidase family;


Pssm-ID: 459761 [Multi-domain]  Cd Length: 213  Bit Score: 37.59  E-value: 3.23e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503961923   44 AKAGYTVCLPRLKGhGTHY---------EDMERTTFHDWVASVEegygWLKQRCQT----IFVTGLSMGGTLTLYLAEHH 110
Cdd:pfam00326  11 ADRGYVVAIANGRG-SGGYgeafhdagkGDLGQNEFDDFIAAAE----YLIEQGYTdpdrLAIWGGSYGGYLTGAALNQR 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503961923  111 PDI--CGI--VPInaaVD------IPAIAAGmtgggelPRYLDsIGSDLKNPDVkelaYEKTPTASllqlarlmaqtKAK 180
Cdd:pfam00326  86 PDLfkAAVahVPV---VDwlaymsDTSLPFT-------ERYME-WGNPWDNEEG----YDYLSPYS-----------PAD 139

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 503961923  181 LDRIVCPALIFVSDEDHVVPPGNADIIFQGISSTEKEiVRLR---NSYHVATLDYDQPMIIERSLEFFAKHAG 250
Cdd:pfam00326 140 NVKVYPPLLLIHGLLDDRVPPWQSLKLVAALQRKGVP-FLLLifpDEGHGIGKPRNKVEEYARELAFLLEYLG 211
Fes COG2382
Enterochelin esterase or related enzyme [Inorganic ion transport and metabolism];
63-117 4.20e-03

Enterochelin esterase or related enzyme [Inorganic ion transport and metabolism];


Pssm-ID: 441948 [Multi-domain]  Cd Length: 314  Bit Score: 37.91  E-value: 4.20e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 503961923  63 EDMERTTFHDWVAS-----VEEGYGWLKQRcQTIFVTGLSMGGTLTLYLAEHHPDICGIV 117
Cdd:COG2382  166 EGPGNDAFERFLAEelipfVEKNYRVSADP-EHRAIAGLSMGGLAALYAALRHPDLFGYV 224
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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