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Conserved domains on  [gi|503974235|ref|WP_014208229|]
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MULTISPECIES: Na+/H+ antiporter subunit G [Acinetobacter calcoaceticus/baumannii complex]

Protein Classification

cation:proton antiporter( domain architecture ID 10003540)

cation:proton antiporter functions in maintaining cation homeostasis and the pH of actively metabolizing cells; it may also be involved in regulating cell volume; similar to Alkalihalophilus pseudofirmus Na(+)/H(+) antiporter subunit G

Gene Ontology:  GO:0015297|GO:0098662|GO:1902600
PubMed:  12027219|16734752|12502567|17218973|9537504
TCDB:  2.A.63

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
MnhG COG1320
Multisubunit Na+/H+ antiporter, MnhG subunit [Inorganic ion transport and metabolism];
4-112 1.25e-34

Multisubunit Na+/H+ antiporter, MnhG subunit [Inorganic ion transport and metabolism];


:

Pssm-ID: 440931  Cd Length: 110  Bit Score: 116.12  E-value: 1.25e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503974235   4 AMEIIVSVFLVFGAFFMLVGSIGMVRLPDLFMRLHAPTKSSTLGLGSFLIASMIFFaFQGRFGFAELLITLLAFITAPVS 83
Cdd:COG1320    1 ILEILVAVLLLLGALFALVGAIGLLRLPDFYTRLHAATKATTLGLGLILLGVALYF-GSGAVSLKLLLIILFLLLTAPVA 79

                         90       100
                 ....*....|....*....|....*....
gi 503974235  84 ANLIAQAALHLRLRSLSGEVPEAIERPLP 112
Cdd:COG1320   80 AHLLARAAYRSGVPPWEKTVVDELAEDLD 108
 
Name Accession Description Interval E-value
MnhG COG1320
Multisubunit Na+/H+ antiporter, MnhG subunit [Inorganic ion transport and metabolism];
4-112 1.25e-34

Multisubunit Na+/H+ antiporter, MnhG subunit [Inorganic ion transport and metabolism];


Pssm-ID: 440931  Cd Length: 110  Bit Score: 116.12  E-value: 1.25e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503974235   4 AMEIIVSVFLVFGAFFMLVGSIGMVRLPDLFMRLHAPTKSSTLGLGSFLIASMIFFaFQGRFGFAELLITLLAFITAPVS 83
Cdd:COG1320    1 ILEILVAVLLLLGALFALVGAIGLLRLPDFYTRLHAATKATTLGLGLILLGVALYF-GSGAVSLKLLLIILFLLLTAPVA 79

                         90       100
                 ....*....|....*....|....*....
gi 503974235  84 ANLIAQAALHLRLRSLSGEVPEAIERPLP 112
Cdd:COG1320   80 AHLLARAAYRSGVPPWEKTVVDELAEDLD 108
PRK12674 PRK12674
putative monovalent cation/H+ antiporter subunit G; Reviewed
 3-97 2.42e-32

putative monovalent cation/H+ antiporter subunit G; Reviewed


Pssm-ID: 237169  Cd Length: 99  Bit Score: 109.92  E-value: 2.42e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503974235   3 FAMEIIVSVFLVFGAFFMLVGSIGMVRLPDLFMRLHAPTKSSTLGLGSFLIASMIFFAfQGRFGFAELLITLLAFITAPV 82
Cdd:PRK12674   1 TILEIIVSVLLLLGAFFALVGAIGLVRLPDVYTRLHAATKATTLGLGLVLLASALYFA-GGGNSLKALLIILFLFLTAPV 79

                         90
                 ....*....|....*
gi 503974235  83 SANLIAQAALHLRLR 97
Cdd:PRK12674  80 AAHLLARAAYRTGVP 94
PhaG_MnhG_YufB pfam03334
Na+/H+ antiporter subunit; This family includes PhaG from Rhizobium meliloti, MnhG from ...
 12-92 1.38e-26

Na+/H+ antiporter subunit; This family includes PhaG from Rhizobium meliloti, MnhG from Staphylococcus aureus, YufB from Bacillus subtilis.


Pssm-ID: 460887  Cd Length: 82  Bit Score: 94.43  E-value: 1.38e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503974235   12 FLVFGAFFMLVGSIGMVRLPDLFMRLHAPTKSSTLGLGSFLIASMIFFAF-QGRFGFAELLITLLAFITAPVSANLIAQA 90
Cdd:pfam03334   1 LLLLGAFFALVGAIGLLRLPDVYTRLHAATKADTLGLGLILLGLALYFGLgGGGVALKLLLIILFLLLTAPVAAHLIARA 80


                  ..
gi 503974235   91 AL 92
Cdd:pfam03334  81 AY 82
CPA3_mnhG_phaG TIGR01300
monovalent cation/proton antiporter, MnhG/PhaG subunit; This model represents a subfamily of ...
 11-93 3.44e-22

monovalent cation/proton antiporter, MnhG/PhaG subunit; This model represents a subfamily of small, transmembrane proteins believed to be components of Na+/H+ and K+/H+ antiporters. Members, including proteins designated MnhG from Staphylococcus aureus and PhaG from Rhizobium meliloti, show some similarity to chain L of the NADH dehydrogenase I, which also translocates protons. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 130367  Cd Length: 97  Bit Score: 83.91  E-value: 3.44e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503974235   11 VFLVFGAFFMLVGSIGMVRLPDLFMRLHAPTKSSTLGLGSFLIASMIFFAF-QGRFGFAELLITLLAFITAPVSANLIAQ 89
Cdd:TIGR01300   1 VLLLIGAFFTLLGAIGLVRFPDVYTRLHAATKGTTLGTILILLGVALIALVlDLAVSIKLLLIALFILLTNPVGAHLLAR 80


                  ....
gi 503974235   90 AALH 93
Cdd:TIGR01300  81 AAYL 84
 
Name Accession Description Interval E-value
MnhG COG1320
Multisubunit Na+/H+ antiporter, MnhG subunit [Inorganic ion transport and metabolism];
4-112 1.25e-34

Multisubunit Na+/H+ antiporter, MnhG subunit [Inorganic ion transport and metabolism];


Pssm-ID: 440931  Cd Length: 110  Bit Score: 116.12  E-value: 1.25e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503974235   4 AMEIIVSVFLVFGAFFMLVGSIGMVRLPDLFMRLHAPTKSSTLGLGSFLIASMIFFaFQGRFGFAELLITLLAFITAPVS 83
Cdd:COG1320    1 ILEILVAVLLLLGALFALVGAIGLLRLPDFYTRLHAATKATTLGLGLILLGVALYF-GSGAVSLKLLLIILFLLLTAPVA 79

                         90       100
                 ....*....|....*....|....*....
gi 503974235  84 ANLIAQAALHLRLRSLSGEVPEAIERPLP 112
Cdd:COG1320   80 AHLLARAAYRSGVPPWEKTVVDELAEDLD 108
PRK12674 PRK12674
putative monovalent cation/H+ antiporter subunit G; Reviewed
 3-97 2.42e-32

putative monovalent cation/H+ antiporter subunit G; Reviewed


Pssm-ID: 237169  Cd Length: 99  Bit Score: 109.92  E-value: 2.42e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503974235   3 FAMEIIVSVFLVFGAFFMLVGSIGMVRLPDLFMRLHAPTKSSTLGLGSFLIASMIFFAfQGRFGFAELLITLLAFITAPV 82
Cdd:PRK12674   1 TILEIIVSVLLLLGAFFALVGAIGLVRLPDVYTRLHAATKATTLGLGLVLLASALYFA-GGGNSLKALLIILFLFLTAPV 79

                         90
                 ....*....|....*
gi 503974235  83 SANLIAQAALHLRLR 97
Cdd:PRK12674  80 AAHLLARAAYRTGVP 94
PRK12671 PRK12671
putative monovalent cation/H+ antiporter subunit G; Reviewed
 7-108 2.50e-28

putative monovalent cation/H+ antiporter subunit G; Reviewed


Pssm-ID: 183670  Cd Length: 120  Bit Score: 100.10  E-value: 2.50e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503974235   7 IIVSVFLVFGAFFMLVGSIGMVRLPDLFMRLHAPTKSSTLGLGSFLIASMIFFAF-QGRFGFAELLITLLAFITAPVSAN 85
Cdd:PRK12671  13 ILVAFFLVLGAGLTLIGTIGLVRLKSFYERLHAPTLGTSWGAGGILIASILYFSVlQSRPVLHEVLIGVFVVVTTPVTLM 92

                         90       100
                 ....*....|....*....|...
gi 503974235  86 LIAQAALHLRLRSLSGEVPEAIE 108
Cdd:PRK12671  93 LLSRAALYRDRSEDSSEKPSALE 115
PhaG_MnhG_YufB pfam03334
Na+/H+ antiporter subunit; This family includes PhaG from Rhizobium meliloti, MnhG from ...
 12-92 1.38e-26

Na+/H+ antiporter subunit; This family includes PhaG from Rhizobium meliloti, MnhG from Staphylococcus aureus, YufB from Bacillus subtilis.


Pssm-ID: 460887  Cd Length: 82  Bit Score: 94.43  E-value: 1.38e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503974235   12 FLVFGAFFMLVGSIGMVRLPDLFMRLHAPTKSSTLGLGSFLIASMIFFAF-QGRFGFAELLITLLAFITAPVSANLIAQA 90
Cdd:pfam03334   1 LLLLGAFFALVGAIGLLRLPDVYTRLHAATKADTLGLGLILLGLALYFGLgGGGVALKLLLIILFLLLTAPVAAHLIARA 80


                  ..
gi 503974235   91 AL 92
Cdd:pfam03334  81 AY 82
CPA3_mnhG_phaG TIGR01300
monovalent cation/proton antiporter, MnhG/PhaG subunit; This model represents a subfamily of ...
 11-93 3.44e-22

monovalent cation/proton antiporter, MnhG/PhaG subunit; This model represents a subfamily of small, transmembrane proteins believed to be components of Na+/H+ and K+/H+ antiporters. Members, including proteins designated MnhG from Staphylococcus aureus and PhaG from Rhizobium meliloti, show some similarity to chain L of the NADH dehydrogenase I, which also translocates protons. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 130367  Cd Length: 97  Bit Score: 83.91  E-value: 3.44e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503974235   11 VFLVFGAFFMLVGSIGMVRLPDLFMRLHAPTKSSTLGLGSFLIASMIFFAF-QGRFGFAELLITLLAFITAPVSANLIAQ 89
Cdd:TIGR01300   1 VLLLIGAFFTLLGAIGLVRFPDVYTRLHAATKGTTLGTILILLGVALIALVlDLAVSIKLLLIALFILLTNPVGAHLLAR 80


                  ....
gi 503974235   90 AALH 93
Cdd:TIGR01300  81 AAYL 84
PRK12586 PRK12586
Na+/H+ antiporter subunit G;
6-91 1.14e-17

Na+/H+ antiporter subunit G;


Pssm-ID: 237147  Cd Length: 145  Bit Score: 73.66  E-value: 1.14e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503974235   6 EIIVSVFLVFGAFFMLVGSIGMVRLPDLFMRLHAPTKSSTLGLGSFLIASMIFFAF-QGRFGFAELLITLLAFITAPVSA 84
Cdd:PRK12586   9 SLIAAIMILLGSIIALISAIGIVKFQDVFLRSHAATKSSTLSVLLTLIGVLIYFIVnTGFFSVRLLLSLVFINLTSPVGM 88


                 ....*..
gi 503974235  85 NLIAQAA 91
Cdd:PRK12586  89 HLIARAA 95
PRK12585 PRK12585
putative monovalent cation/H+ antiporter subunit G; Reviewed
 1-97 2.71e-16

putative monovalent cation/H+ antiporter subunit G; Reviewed


Pssm-ID: 183610  Cd Length: 197  Bit Score: 71.64  E-value: 2.71e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503974235   1 MQFAMEIIVSVFLVFGAFFMLVGSIGMVRLPDLFMRLHAPTKSSTLGLGSFLIASMIFFAFQGR-FGFAELLITLLAFIT 79
Cdd:PRK12585   1 MNVIIEIIISIMILIGGLLSILAAIGVIRLPDVYTRTHAAGISNTFGVSLLLFATVGYFFHSGEgFNARVLLAVLFIFLT 80

                         90       100
                 ....*....|....*....|....
gi 503974235  80 APVSANLIAQAA------LHLRLR 97
Cdd:PRK12585  81 TPVASHLINRAAydtgvpLAIRIR 104
PRK12587 PRK12587
putative monovalent cation/H+ antiporter subunit G; Reviewed
 7-95 2.18e-10

putative monovalent cation/H+ antiporter subunit G; Reviewed


Pssm-ID: 183612  Cd Length: 118  Bit Score: 54.02  E-value: 2.18e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503974235   7 IIVSV---FLVFGAFFMLVGSIGMVRLPDLFMRLHAPTKSSTLGLGSFLIASMIFFAFQGRFGFAELLITLL-AFITAPV 82
Cdd:PRK12587   5 ILISLaliFVIIGALISALAAIGLLRLEDVYSRAHAAGKASTLGAMSLLFGTFLYFIATQGYVNMQLIVGIIfVLITGPL 84

                         90
                 ....*....|...
gi 503974235  83 SANLIAQAALHLR 95
Cdd:PRK12587  85 SSHMIMKAAYNIK 97
PRK12672 PRK12672
putative monovalent cation/H+ antiporter subunit G; Reviewed
 6-91 2.39e-10

putative monovalent cation/H+ antiporter subunit G; Reviewed


Pssm-ID: 183671  Cd Length: 118  Bit Score: 53.95  E-value: 2.39e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503974235   6 EIIVSVFLVFGAFFMLVGSIGMVRLPDLFMRLHAPTKSSTLGLGSFLIASMIFFAFQGRFG----FAEL----LITLLAF 77
Cdd:PRK12672   4 EYLIYIFLAIGVTFNLLGSIALHRFPDVYTRLHGATKCTTFGTIFAVLAVVTHALYRLRLTgdpkYLQMalhsFVALIAL 83

                         90
                 ....*....|....*
gi 503974235  78 -ITAPVSANLIAQAA 91
Cdd:PRK12672  84 lLTNPVGAHAIARAA 98
PRK12675 PRK12675
putative monovalent cation/H+ antiporter subunit G; Reviewed
 7-91 6.37e-09

putative monovalent cation/H+ antiporter subunit G; Reviewed


Pssm-ID: 171652  Cd Length: 104  Bit Score: 50.17  E-value: 6.37e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503974235   7 IIVSVFLVFGAFFMLVGSIGMVRLPDLFMRLHAPTKSSTLGLGSFLIASMIF--FAFQGRFGFAELLItLLAFITaPVSA 84
Cdd:PRK12675   1 MIELLFLLFGYSIMFFGALGLLRFPDVYTRLHAATKCDTGGAMGIILALALAsdASLLIKLKFLVLAF-LIAMIN-PMVS 78


                 ....*..
gi 503974235  85 NLIAQAA 91
Cdd:PRK12675  79 HAIARGA 85
PRK12592 PRK12592
putative monovalent cation/H+ antiporter subunit G; Reviewed
 2-91 5.30e-08

putative monovalent cation/H+ antiporter subunit G; Reviewed


Pssm-ID: 183613  Cd Length: 126  Bit Score: 47.94  E-value: 5.30e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503974235   2 QFAMEIIVSVFLVFGAFFMLVGSIGMVRLPDLFMRLHAPTKSSTLGLGSFLIASMIFFAFQGRFGFAE-------LLITL 74
Cdd:PRK12592   4 QLFTDIVSLVFILSGAFLSFSASIGLIRFRDTMSRVHAITKPQTTGLILTVVGAIIRVLGHEDFDQSQrgdlgvlVLLVL 83

                         90
                 ....*....|....*..
gi 503974235  75 LAFITAPVSANLIAQAA 91
Cdd:PRK12592  84 FALLTSPVTAQRVGRVS 100
PRK12670 PRK12670
putative monovalent cation/H+ antiporter subunit G; Reviewed
 5-93 1.14e-07

putative monovalent cation/H+ antiporter subunit G; Reviewed


Pssm-ID: 183669  Cd Length: 99  Bit Score: 46.64  E-value: 1.14e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503974235   5 MEIIVSVFLVFGAFFMLVGSIGMVRLPDLFMRLHAPTKSSTLGLGSFLIAsmifFAFQGRFGFAELLITLLAF---ITAP 81
Cdd:PRK12670   2 LPMLGMITLGLGIFLIVISVIGVIRFPDFYTRLHAAGITDSLGAALILIG----LAMQCGFSVFTVKVLLLICllwITST 77

                         90
                 ....*....|..
gi 503974235  82 VSANLIAQAALH 93
Cdd:PRK12670  78 TASYALARSAYK 89
PRK06286 PRK06286
putative monovalent cation/H+ antiporter subunit G; Reviewed
 1-93 3.01e-03

putative monovalent cation/H+ antiporter subunit G; Reviewed


Pssm-ID: 235769  Cd Length: 91  Bit Score: 34.63  E-value: 3.01e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503974235   1 MQFAMEIIVSVFLVFGAFFMLVGSIGMVRLPD-----LFMRLHAptksstlgLGSFLIASMIFFafqgrFGFAELLITLL 75
Cdd:PRK06286   1 MMQFVGIIQDILLIIASIGILIASIRLWRVEKdrknvVYARIHI--------LGVIDIACILIL-----LALGQPLLALT 67

                         90
                 ....*....|....*...
gi 503974235  76 AFITAPVSANLIAQAALH 93
Cdd:PRK06286  68 YLILAPFLAHAIANAHYN 85
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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