|
Name |
Accession |
Description |
Interval |
E-value |
| PRK08045 |
PRK08045 |
cystathionine gamma-synthase; Provisional |
1-386 |
0e+00 |
|
cystathionine gamma-synthase; Provisional
Pssm-ID: 169194 [Multi-domain] Cd Length: 386 Bit Score: 792.56 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 1 MTRKQATIAVRSGLNDDEQYGCVVPPIHLSSTYNFTGFNEPRAHDYSRRGNPTRDVVQRALAELEGGAGAVLTNTGMSAI 80
Cdd:PRK08045 1 MTRKQATIAVRSGLNDDEQYGCVVPPIHLSSTYNFTGFNEPRAHDYSRRGNPTRDVVQRALAELEGGAGAVLTNTGMSAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 81 LLVTTVFLKPGDLLVAPHDCYGGSYRLFDSLAKRGCYRVLFVDQNDEQALSAALAEKPKLVLVESPSNPLLRVVDIAKIC 160
Cdd:PRK08045 81 HLVTTVFLKPGDLLVAPHDCYGGSYRLFDSLAKRGCYRVLFVDQGDEQALRAALAEKPKLVLVESPSNPLLRVVDIAKIC 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 161 GLAREAGAVSVVDNTFLSPALQNPLALGADLVLHSCTKYLNGHSDVVAGVVIAKDPATVTELAWWANNIGVTGGAFDSYL 240
Cdd:PRK08045 161 HLAREAGAVSVVDNTFLSPALQNPLALGADLVLHSCTKYLNGHSDVVAGVVIAKDPDVVTELAWWANNIGVTGGAFDSYL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 241 LLRGLRTLSPRMEVAQRNALAIVDYLKSQPLVKKLYHPSLPENQGHEIAARQQKGFGAMLSFELDGDEQTLRRFLSGLSL 320
Cdd:PRK08045 241 LLRGLRTLVPRMELAQRNAQAIVKYLQTQPLVKKLYHPSLPENQGHEIAARQQKGFGAMLSFELDGDEQTLRRFLGGLSL 320
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 503993435 321 FTLAESLGGVESLISHAATMTHAGMAPEARAAAGISETLLRISTGIEDGEDLIADLENGFRAANEE 386
Cdd:PRK08045 321 FTLAESLGGVESLISHAATMTHAGMAPEARAAAGISETLLRISTGIEDGEDLIADLENGFRAANKG 386
|
|
| O_succ_thio_ly |
TIGR02080 |
O-succinylhomoserine (thiol)-lyase; This family consists of O-succinylhomoserine (thiol)-lyase, ... |
2-383 |
0e+00 |
|
O-succinylhomoserine (thiol)-lyase; This family consists of O-succinylhomoserine (thiol)-lyase, one of three different enzymes designated cystathionine gamma-synthase and involved in methionine biosynthesis. In all three cases, sulfur is added by transsulfuration from Cys to yield cystathionine rather than by a sulfhydrylation step that uses H2S directly and bypasses cystathionine. [Amino acid biosynthesis, Aspartate family]
Pssm-ID: 131135 Cd Length: 382 Bit Score: 726.98 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 2 TRKQATIAVRSGLNDDEQYGCVVPPIHLSSTYNFTGFNEPRAHDYSRRGNPTRDVVQRALAELEGGAGAVLTNTGMSAIL 81
Cdd:TIGR02080 1 TRKQATIAVRSGLNSDTQYGCVVPPIYLSTTYNFTGFNEPRAYDYSRSGNPTRDLLQQALAELEGGAGAVVTNTGMSAIH 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 82 LVTTVFLKPGDLLVAPHDCYGGSYRLFDSLAKRGCYRVLFVDQNDEQALSAALAEKPKLVLVESPSNPLLRVVDIAKICG 161
Cdd:TIGR02080 81 LVTTALLGPDDLLVAPHDCYGGTYRLLNALAKKGCFRVLFVDQGDEQALRAALAQKPKLVLIETPSNPLLRVVDIAKICH 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 162 LAREAGAVSVVDNTFLSPALQNPLALGADLVLHSCTKYLNGHSDVVAGVVIAKDPATVTELAWWANNIGVTGGAFDSYLL 241
Cdd:TIGR02080 161 LAKAVGAVVVVDNTFLSPALQNPLALGADLVLHSCTKYLNGHSDVIAGAVIAKDPQVAEELAWWANNLGVTGGAFDSYLT 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 242 LRGLRTLSPRMEVAQRNALAIVDYLKSQPLVKKLYHPSLPENQGHEIAARQQKGFGAMLSFELDGDEQTLRRFLSGLSLF 321
Cdd:TIGR02080 241 LRGLRTLVARMRLQQRNAQAIVEYLQTQPLVKKIYYPGLPDHPGHEIAARQQKGFGAMLSFELKGGEQTVRRFLGGLSLF 320
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 503993435 322 TLAESLGGVESLISHAATMTHAGMAPEARAAAGISETLLRISTGIEDGEDLIADLENGFRAA 383
Cdd:TIGR02080 321 TLAESLGGVESLIAHPATMTHAAMGPEARAEAGISDTLLRLSVGLEDADDLIADLEQGLRAA 382
|
|
| Cys_Met_Meta_PP |
pfam01053 |
Cys/Met metabolism PLP-dependent enzyme; This family includes enzymes involved in cysteine and ... |
6-381 |
0e+00 |
|
Cys/Met metabolism PLP-dependent enzyme; This family includes enzymes involved in cysteine and methionine metabolism. The following are members: Cystathionine gamma-lyase, Cystathionine gamma-synthase, Cystathionine beta-lyase, Methionine gamma-lyase, OAH/OAS sulfhydrylase, O-succinylhomoserine sulfhydrylase All of these members participate is slightly different reactions. All these enzymes use PLP (pyridoxal-5'-phosphate) as a cofactor.
Pssm-ID: 395837 [Multi-domain] Cd Length: 376 Bit Score: 566.09 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 6 ATIAVRSGLNDDEQYGCVVPPIHLSSTYNFTGFNEPRAHDYSRRGNPTRDVVQRALAELEGGAGAVLTNTGMSAILLVTT 85
Cdd:pfam01053 1 DTLAVHAGQRPDPQTGAVSVPIYLTSTYVFDFAGEEGGYDYSRSGNPTRDVLEERIAALEGGAAALAFSSGMAAITAAIL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 86 VFLKPGDLLVAPHDCYGGSYRLFDSLAKRGCYRVLFVDQNDEQALSAALAEKPKLVLVESPSNPLLRVVDIAKICGLARE 165
Cdd:pfam01053 81 ALLKAGDHIVATDDLYGGTYRLFNKVLPRFGIEVTFVDTSDPEDLEAAIKPNTKAVYLETPTNPLLKVVDIEAIAKLAKK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 166 AGAVSVVDNTFLSPALQNPLALGADLVLHSCTKYLNGHSDVVAGVVIAKDPATVTELAWWANNIGVTGGAFDSYLLLRGL 245
Cdd:pfam01053 161 HGILVVVDNTFASPYLQRPLDLGADIVVHSATKYIGGHSDVVGGVIVVNGEELGKELYFLQNATGAVLSPFDAWLLLRGL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 246 RTLSPRMEVAQRNALAIVDYLKSQPLVKKLYHPSLPENQGHEIAARQQKGFGAMLSFELDGDEQTLRRFLSGLSLFTLAE 325
Cdd:pfam01053 241 KTLGLRMEQHQENAQKVAEFLESHPKVEKVYYPGLPSHPGHELAKRQMKGFGGMLSFELKGGLEAAKKFLDNLKLFSLAV 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 503993435 326 SLGGVESLISHAATMTHAGMAPEARAAAGISETLLRISTGIEDGEDLIADLENGFR 381
Cdd:pfam01053 321 SLGGVESLISHPATMTHASIPPEEREAAGITDDLIRLSVGIEDVDDLIADLKQALE 376
|
|
| MetC |
COG0626 |
Cystathionine beta-lyase/cystathionine gamma-synthase [Amino acid transport and metabolism]; ... |
4-383 |
0e+00 |
|
Cystathionine beta-lyase/cystathionine gamma-synthase [Amino acid transport and metabolism]; Cystathionine beta-lyase/cystathionine gamma-synthase is part of the Pathway/BioSystem: Methionine biosynthesis
Pssm-ID: 440391 [Multi-domain] Cd Length: 389 Bit Score: 556.59 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 4 KQATIAVRSGLNDDEQYGCVVPPIHLSSTYNFTGFNEPRA--------HDYSRRGNPTRDVVQRALAELEGGAGAVLTNT 75
Cdd:COG0626 2 GPATRAVHAGRDPDPQTGAVSPPIYLTSTFVFPSAEALAArfageeggYIYSRYGNPTRRALEEALAALEGGEAALAFAS 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 76 GMSAILLVTTVFLKPGDLLVAPHDCYGGSYRLFDSLAKRGCYRVLFVDQNDEQALSAALAEKPKLVLVESPSNPLLRVVD 155
Cdd:COG0626 82 GMAAISAVLLALLKAGDHVVASDDLYGGTRRLLDKVLARFGIEVTFVDPTDLAAVEAAIRPNTKLVFLETPSNPTLEVVD 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 156 IAKICGLAREAGAVSVVDNTFLSPALQNPLALGADLVLHSCTKYLNGHSDVVAGVVIAKDPATVTELAWWANNIGVTGGA 235
Cdd:COG0626 162 IAAIAAIAHAAGALLVVDNTFATPLLQRPLELGADIVVHSATKYLGGHSDVLGGAVVGRDEELAERLRFLQNALGAVLSP 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 236 FDSYLLLRGLRTLSPRMEVAQRNALAIVDYLKSQPLVKKLYHPSLPENQGHEIAARQQKGFGAMLSFELDGDEQTLRRFL 315
Cdd:COG0626 242 FDAWLLLRGLKTLALRMERHCENALAVAEWLEAHPAVARVYYPGLPSHPGHELAKRQMSGFGGMLSFELKGGREAARRFL 321
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 503993435 316 SGLSLFTLAESLGGVESLISHAATMTHAGMAPEARAAAGISETLLRISTGIEDGEDLIADLENGFRAA 383
Cdd:COG0626 322 DALKLFTLAVSLGGVESLITHPATMTHRSLPPEERAALGITDGLVRLSVGLEDVDDLIADLEQALAAL 389
|
|
| PRK08861 |
PRK08861 |
O-succinylhomoserine (thiol)-lyase; |
2-385 |
0e+00 |
|
O-succinylhomoserine (thiol)-lyase;
Pssm-ID: 181567 [Multi-domain] Cd Length: 388 Bit Score: 545.26 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 2 TRKQATIAVRSGLNDDEQYGCVVPPIHLSSTYNFTGFNEPRAHDYSRRGNPTRDVVQRALAELEGGAGAVLTNTGMSAIL 81
Cdd:PRK08861 3 TRKPATIAVRTGIESDSQYHAVVPPIYLSTNYGFPAFGEVPKYDYTRSGNPNRGLLEQTLSELESGKGAVVTNCGTSALN 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 82 LVTTVFLKPGDLLVAPHDCYGGSYRLFDSLAKRGCYRVLFVDQNDEQALSAALAEKPKLVLVESPSNPLLRVVDIAKICG 161
Cdd:PRK08861 83 LWVSALLGPDDLIVAPHDCYGGTYRLFNTRANKGDFKVQFVDQSDAAALDAALAKKPKLILLETPSNPLVRVVDIAELCQ 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 162 LAREAGAVSVVDNTFLSPALQNPLALGADLVLHSCTKYLNGHSDVVAGVVIAKDPATVTELAWWANNIGVTGGAFDSYLL 241
Cdd:PRK08861 163 KAKAVGALVAVDNTFLTPVLQKPLELGADFVIHSTTKYINGHSDVIGGVLITKTKEHAEELAWWGNCIGATGTPFDSYMT 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 242 LRGLRTLSPRMEVAQRNALAIVDYLKSQPLVKKLYHPSLPENQGHEIAARQQKGFGAMLSFELDGDEQTLRRFLSGLSLF 321
Cdd:PRK08861 243 LRGIRTLGARMRVHEESAQQILAYLQTQSLVGTIYHPSLPEHPGHEIAKKQQSGFGSMLSFEFAGSFEQLKVFVKALALF 322
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 503993435 322 TLAESLGGVESLISHAATMTHAGMAPEARAAAGISETLLRISTGIEDGEDLIADLENGFRAANE 385
Cdd:PRK08861 323 SLAESLGGVESLICHPASMTHRAMGEEALAEAGVSQQLLRLSVGLEDAQDLIADLDQAFAKAAE 386
|
|
| CGS_like |
cd00614 |
CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed ... |
21-381 |
0e+00 |
|
CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of antimicrobials and herbicides. This subgroup also includes cystathionine gamma-lyases (CGL), O-acetylhomoserine sulfhydrylases and O-acetylhomoserine thiol lyases. CGL's are very similar to CGS's. Members of this group are widely distributed among all three forms of life.
Pssm-ID: 99738 [Multi-domain] Cd Length: 369 Bit Score: 512.52 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 21 GCVVPPIHLSSTYNFTGFNEPRA--------HDYSRRGNPTRDVVQRALAELEGGAGAVLTNTGMSAILLVTTVFLKPGD 92
Cdd:cd00614 1 GAVAPPIYQTSTFVFPSPAEAADlfalreggYIYSRIGNPTVDALEKKLAALEGGEAALAFSSGMAAISTVLLALLKAGD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 93 LLVAPHDCYGGSYRLFDSLAKRGCYRVLFVDQNDEQALSAALAEKPKLVLVESPSNPLLRVVDIAKICGLAREAGAVSVV 172
Cdd:cd00614 81 HVVASDDLYGGTYRLFERLLPKLGIEVTFVDPDDPEALEAAIKPETKLVYVESPTNPTLKVVDIEAIAELAHEHGALLVV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 173 DNTFLSPALQNPLALGADLVLHSCTKYLNGHSDVVAGVVIAKDPATVTELAWWANNIGVTGGAFDSYLLLRGLRTLSPRM 252
Cdd:cd00614 161 DNTFATPYLQRPLELGADIVVHSATKYIGGHSDVIAGVVVGSGEALIQRLRFLRLALGTILSPFDAWLLLRGLKTLPLRM 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 253 EVAQRNALAIVDYLKSQPLVKKLYHPSLPENQGHEIAARQQKGFGAMLSFELDGDEQTLRRFLSGLSLFTLAESLGGVES 332
Cdd:cd00614 241 ERHSENALKVAEFLEKHPKVERVYYPGLPSHPQHELAKKQMSGYGGVFSFELKGGLEAAKKFLNALKLFSLAVSLGGVES 320
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 503993435 333 LISHAATMTHAGMAPEARAAAGISETLLRISTGIEDGEDLIADLENGFR 381
Cdd:cd00614 321 LVEHPASMTHSQLPPEERAAAGITPGLVRLSVGIEDVEDLIADLEQALK 369
|
|
| PRK08776 |
PRK08776 |
O-succinylhomoserine (thiol)-lyase; |
6-383 |
0e+00 |
|
O-succinylhomoserine (thiol)-lyase;
Pssm-ID: 181554 [Multi-domain] Cd Length: 405 Bit Score: 512.23 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 6 ATIAVRSGLNDDEQYGCVVPPIHLSSTYNFTGFNEPRAHDYSRRGNPTRDVVQRALAELEGGAGAVLTNTGMSAILLVTT 85
Cdd:PRK08776 14 ATAAVRAGIDRDTAYGAVTPPIVLSSNFSFDGFGNKRQYDYTRSGNPTRDLLGEALAELEGGAGGVITATGMGAINLVLN 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 86 VFLKPGDLLVAPHDCYGGSYRLFDSLAKRGCYRVLFVDQNDEQALSAALAEKPKLVLVESPSNPLLRVVDIAKICGLARE 165
Cdd:PRK08776 94 ALLQPGDTLVVPHDAYGGSWRLFNALAKKGHFALITADLTDPRSLADALAQSPKLVLIETPSNPLLRITDLRFVIEAAHK 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 166 AGAVSVVDNTFLSPALQNPLALGADLVLHSCTKYLNGHSDVVAGVVIAKDPATVTELAWWANNIGVTGGAFDSYLLLRGL 245
Cdd:PRK08776 174 VGALTVVDNTFLSPALQKPLEFGADLVLHSTTKYINGHSDVVGGAVVARDAELHQQLVWWANALGLTGSPFDAFLTLRGL 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 246 RTLSPRMEVAQRNALAIVDYLKSQPLVKKLYHPSLPENQGHEIAARQQKGFGAMLSFELDGDEQTLRRFLSGLSLFTLAE 325
Cdd:PRK08776 254 RTLDARLRVHQENADAIAALLDGHAAVNQVYYPGLASHPGHALAARQQKGFGAMLSFELEGGEAAVRAFVDGLRYFTLAE 333
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 503993435 326 SLGGVESLISHAATMTHAGMAPEARAAAGISETLLRISTGIEDGEDLIADLENGFRAA 383
Cdd:PRK08776 334 SLGGVESLIAHPASMTHAAMTAEARAAAGISDGLLRLSVGIESAEDLLIDLRAGLARA 391
|
|
| PRK07811 |
PRK07811 |
cystathionine gamma-synthase; Provisional |
6-382 |
1.88e-143 |
|
cystathionine gamma-synthase; Provisional
Pssm-ID: 236104 [Multi-domain] Cd Length: 388 Bit Score: 412.50 E-value: 1.88e-143
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 6 ATIAVRSGLNDDEQYGCVVPPIHLSSTYNFTGFNEPRA-HDYSRRGNPTRDVVQRALAELEGGAGAVLTNTGMSAILLVT 84
Cdd:PRK07811 14 ATRAIHAGYEPDPATGAVNPPIYASSTFAQDGVGGLRGgYEYARTGNPTRTALEEQLAALEGGAYGRAFSSGMAATDCLL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 85 TVFLKPGDLLVAPHDCYGGSYRLFDSLAKRGCYRVLFVDQNDEQALSAALAEKPKLVLVESPSNPLLRVVDIAKICGLAR 164
Cdd:PRK07811 94 RAVLRPGDHIVIPNDAYGGTFRLIDKVFTRWGVEYTPVDLSDLDAVRAAITPRTKLIWVETPTNPLLSITDIAALAELAH 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 165 EAGAVSVVDNTFLSPALQNPLALGADLVLHSCTKYLNGHSDVVAGVVIAKDPATVTELAWWANNIGVTGGAFDSYLLLRG 244
Cdd:PRK07811 174 DAGAKVVVDNTFASPYLQQPLALGADVVVHSTTKYIGGHSDVVGGALVTNDEELDEAFAFLQNGAGAVPGPFDAYLTLRG 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 245 LRTLSPRMEVAQRNALAIVDYLKSQPLVKKLYHPSLPENQGHEIAARQQKGFGAMLSFELDGDEQTLRRFLSGLSLFTLA 324
Cdd:PRK07811 254 LKTLAVRMDRHSENAEAVAEFLAGHPEVSTVLYPGLPSHPGHEVAARQMRGFGGMVSVRLAGGEEAARDFCARTKVFTLA 333
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 503993435 325 ESLGGVESLISHAATMTHAgmapearAAAG----ISETLLRISTGIEDGEDLIADLENGFRA 382
Cdd:PRK07811 334 ESLGGVESLIEHPSAMTHA-------STAGsqleVPDDLVRLSVGIEDVADLLADLEQALGQ 388
|
|
| PRK07671 |
PRK07671 |
bifunctional cystathionine gamma-lyase/homocysteine desulfhydrase; |
1-380 |
2.19e-127 |
|
bifunctional cystathionine gamma-lyase/homocysteine desulfhydrase;
Pssm-ID: 181076 [Multi-domain] Cd Length: 377 Bit Score: 371.36 E-value: 2.19e-127
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 1 MTRKqaTIAVRSGLNDDEQYGCVVPPIHLSSTYNFTGFNEPRAHDYSRRGNPTRDVVQRALAELEGGAGAVLTNTGMSAI 80
Cdd:PRK07671 1 MRAK--TKLIHGGIIGDPSTGAVSVPIYQVSTYKQEAVGKHQGYEYSRTGNPTRAALEELIAVLEGGHAGFAFGSGMAAI 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 81 LLVTTVFlKPGDLLVAPHDCYGGSYRLFDSLAKRGCYRVLFVDQNDEQALSAALAEKPKLVLVESPSNPLLRVVDIAKIC 160
Cdd:PRK07671 79 TAVMMLF-SSGDHVILTDDVYGGTYRVMTKVLNRFGIEHTFVDTSNLEEVEEAIRPNTKAIYVETPTNPLLKITDIKKIS 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 161 GLAREAGAVSVVDNTFLSPALQNPLALGADLVLHSCTKYLNGHSDVVAGVVIAKDPATVTELAWWANNIGVTGGAFDSYL 240
Cdd:PRK07671 158 TIAKEKGLLTIVDNTFMTPYWQSPISLGADIVLHSATKYLGGHSDVVAGLVVVNSPELAEDLHFVQNSTGGILGPQDSWL 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 241 LLRGLRTLSPRMEVAQRNALAIVDYLKSQPLVKKLYHPSLPENQGHEIAARQQKGFGAMLSFELdGDEQTLRRFLSGLSL 320
Cdd:PRK07671 238 LLRGLKTLGIRMEEHETNSRAIAEFLNNHPAVNKVYYPGLPSHPNHELAKEQANGFGGMISFDV-GSEETANKVLERLQY 316
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 321 FTLAESLGGVESLISHAATMTHAGMAPEARAAAGISETLLRISTGIEDGEDLIADLENGF 380
Cdd:PRK07671 317 FTLAESLGAVESLISIPSQMTHASIPADRRKELGITDGLIRISVGIEDGEDLIEDLAQAL 376
|
|
| PRK08247 |
PRK08247 |
methionine biosynthesis PLP-dependent protein; |
1-384 |
6.72e-126 |
|
methionine biosynthesis PLP-dependent protein;
Pssm-ID: 181320 [Multi-domain] Cd Length: 366 Bit Score: 367.11 E-value: 6.72e-126
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 1 MTRKQATIAVRSGLNDDEQYGCVVPPIHLSSTYNFTGFNEPRAHDYSRRGNPTRDVVQRALAELEGGAGAVLTNTGMSAI 80
Cdd:PRK08247 1 QMSTIETKLAQIGNRSDERTGTVNPPVYFSTAYRHEGIGESTGFDYSRTGNPTRGVLEQAIADLEGGDQGFACSSGMAAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 81 LLVTTVFlKPGDLLVAPHDCYGGSYRLFDSLAKRGCYRVLFVDQNDEQALSAALAEKPKLVLVESPSNPLLRVVDIAKIC 160
Cdd:PRK08247 81 QLVMSLF-RSGDELIVSSDLYGGTYRLFEEHWKKWNVRFVYVNTASLKAIEQAITPNTKAIFIETPTNPLMQETDIAAIA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 161 GLAREAGAVSVVDNTFLSPALQNPLALGADLVLHSCTKYLNGHSDVVAGVVIAKDPATVTELAWWANNIGVTGGAFDSYL 240
Cdd:PRK08247 160 KIAKKHGLLLIVDNTFYTPVLQRPLEEGADIVIHSATKYLGGHNDVLAGLVVAKGQELCERLAYYQNAAGAVLSPFDSWL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 241 LLRGLRTLSPRMEVAQRNALAIVDYLKSQPLVKKLYHPslpenqgheiaarqqkGFGAMLSFELDgDEQTLRRFLSGLSL 320
Cdd:PRK08247 240 LIRGMKTLALRMRQHEENAKAIAAFLNEQPGVTDVLYP----------------GRGGMLSFRLQ-DEEWVNPFLKSLKL 302
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 503993435 321 FTLAESLGGVESLISHAATMTHAGMAPEARAAAGISETLLRISTGIEDGEDLIADLENGFRAAN 384
Cdd:PRK08247 303 ITFAESLGGVESFITYPATQTHADIPEEIRIANGVCNRLLRFSVGIENVEDLIADLKQAFKQVK 366
|
|
| PRK08064 |
PRK08064 |
cystathionine beta-lyase MetC; |
17-385 |
5.08e-119 |
|
cystathionine beta-lyase MetC;
Pssm-ID: 236146 [Multi-domain] Cd Length: 390 Bit Score: 350.61 E-value: 5.08e-119
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 17 DEQYGCVVPPIHLSSTYNFTGFNEPRAHDYSRRGNPTRDVVQRALAELEGGAGAVLTNTGMSAIllvTTVF--LKPGDLL 94
Cdd:PRK08064 19 DKQTGAVNVPIYHASTFHQFDFDTFGKYDYSRSGNPTREALEDIIAELEGGTKGFAFASGMAAI---STAFllLSKGDHV 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 95 VAPHDCYGGSYRLFDSLAKRGCYRVLFVDQNDEQALSAALAEKPKLVLVESPSNPLLRVVDIAKICGLAREAGAVSVVDN 174
Cdd:PRK08064 96 LISEDVYGGTYRMITEVLSRFGIEHTFVDMTNLEEVAQNIKPNTKLFYVETPSNPLLKVTDIRGVVKLAKAIGCLTFVDN 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 175 TFLSPALQNPLALGADLVLHSCTKYLNGHSDVVAGVVIAKDPATVTELAWWANNIGVTGGAFDSYLLLRGLRTLSPRMEV 254
Cdd:PRK08064 176 TFLTPLLQKPLDLGADVVLHSATKFLAGHSDVLAGLAVVKDEELAQKLYFLQNSFGAVLGVQDCWLVLRGLKTLHVRLEH 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 255 AQRNALAIVDYLKSQPLVKKLYHPSLPENQGHEIAARQQKGFGAMLSFELdGDEQTLRRFLSGLSLFTLAESLGGVESLI 334
Cdd:PRK08064 256 SSETANKIALYLQEHPKVQNVYYPGLQTHLGFDIQQSQATSAGAVLSFTL-QSEEAVRQFVSHVKLPVFAVSLGAVESIL 334
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 503993435 335 SHAATMTHAGMAPEARAAAGISETLLRISTGIEDGEDLIADLENGFRAANE 385
Cdd:PRK08064 335 SYPAKMSHAAMPKEERDERGITDGLLRLSVGLENVDDLIADFEQALSYVEE 385
|
|
| PRK06176 |
PRK06176 |
cystathionine gamma-synthase; |
7-382 |
6.82e-118 |
|
cystathionine gamma-synthase;
Pssm-ID: 180443 [Multi-domain] Cd Length: 380 Bit Score: 347.27 E-value: 6.82e-118
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 7 TIAVRSGLNDDEQYGCVVPPIHLSSTYNFTGFNEPRAHDYSRRGNPTRDVVQRALAELEGGAGAVLTNTGMSAILLVTTV 86
Cdd:PRK06176 5 TKLIHGGISEDTTTGAVSVPIYQTSTYRQDAIGRPKGYEYSRSGNPTRFALEELIADLEGGVKGFAFASGLAGIHAVFSL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 87 FlKPGDLLVAPHDCYGGSYRLFDSLAKRGCYRVLFVDQNDEQALSAALAEKPKLVLVESPSNPLLRVVDIAKICGLAREA 166
Cdd:PRK06176 85 F-QSGDHVLLGDDVYGGTFRLFDKVLVKNGLSCTIIDTSDLSQIKKAIKPNTKALYLETPSNPLLKITDLAQCASVAKDH 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 167 GAVSVVDNTFLSPALQNPLALGADLVLHSCTKYLNGHSDVVAGVVIAKDPATVTELAWWANNIGVTGGAFDSYLLLRGLR 246
Cdd:PRK06176 164 GLLTIVDNTFATPYYQNPLLLGADIVVHSGTKYLGGHSDVVAGLVTTNNEALAQEIAFFQNAIGGVLGPQDSWLLQRGIK 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 247 TLSPRMEVAQRNALAIVDYLKSQPLVKKLYHPSLPENQGHEIAARQQKGFGAMLSFELDGDEQtLRRFLSGLSLFTLAES 326
Cdd:PRK06176 244 TLGLRMEAHQKNALCVAEFLEKHPKVEKVYYPGLPTHPNHELAKKQMRGFSGMLSFTLKNDSE-AVAFVESLKLFILGES 322
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 503993435 327 LGGVESLISHAATMTHAGMAPEARAAAGISETLLRISTGIEDGEDLIADLENGFRA 382
Cdd:PRK06176 323 LGGVESLVGIPAFMTHACIPKEQREAAGIRDGLVRLSVGIEHEQDLLEDLEQAFAK 378
|
|
| cysta_beta_ly_E |
TIGR01329 |
cystathionine beta-lyase, eukaryotic; This model represents cystathionine beta-lyase ... |
6-383 |
1.36e-117 |
|
cystathionine beta-lyase, eukaryotic; This model represents cystathionine beta-lyase (alternate name: beta-cystathionase), one of several pyridoxal-dependent enzymes of cysteine, methionine, and homocysteine metabolism. This enzyme is involved in the biosynthesis of Met from Cys.
Pssm-ID: 273557 [Multi-domain] Cd Length: 378 Bit Score: 346.43 E-value: 1.36e-117
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 6 ATIAVRSGlNDDEQYGCVVPPIHLSSTYNFTGFNEPRAHDYSRRGNPTRDVVQRALAELEGGAGAVLTNTGMSAILLVTT 85
Cdd:TIGR01329 2 STLLVNTD-NKNDPYDASSMPIYQTATFKQPLAIENGPYDYTRSGNPTRTALESLLAKLDKADRAFAFSSGMAALDVITR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 86 VfLKPGDLLVAPHDCYGGSYRLFDSLAKRGCYRVLFVDQNDEQALSAALAEKPKLVLVESPSNPLLRVVDIAKICGLARE 165
Cdd:TIGR01329 81 L-LNNGDEIIAGDDLYGGTDRLLTQVVPRSGVVVVHVDTTDLDKVKAALGPKTKLVLLESPTNPLQKIVDIRKISEMAHA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 166 AGAVSVVDNTFLSPALQNPLALGADLVLHSCTKYLNGHSDVVAGVVIAKDPATVTELAWWANNIGVTGGAFDSYLLLRGL 245
Cdd:TIGR01329 160 QNALVVVDNTMMSPLLCNPLELGADIVYHSATKFLAGHSDVMAGVLAVKGEEIAKKVYFLQNSTGSGLAPFDCWLLLRGI 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 246 RTLSPRMEVAQRNALAIVDYLKSQPLVKKLYHPSLPENQGHEIAARQQKGFGAMLSFElDGDEQTLRRFLSGLSLFTLAE 325
Cdd:TIGR01329 240 KTLAIRIEKQQENARAIAMFLSTHPRVKKVRYAGLPSHPGFHLHFSQAKGAGSVLSFE-TGSVALSKRLVEATKLFSITV 318
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 503993435 326 SLGGVESLISHAATMTHAGMAPEARAAAGISETLLRISTGIEDGEDLIADLENGFRAA 383
Cdd:TIGR01329 319 SFGSVNSLISMPCFMSHASIPAEVREERGLPEDLVRLSVGIEDVDDLISDLDIAFVTA 376
|
|
| MET17 |
COG2873 |
O-acetylhomoserine/O-acetylserine sulfhydrylase, pyridoxal phosphate-dependent [Amino acid ... |
1-383 |
9.12e-117 |
|
O-acetylhomoserine/O-acetylserine sulfhydrylase, pyridoxal phosphate-dependent [Amino acid transport and metabolism]; O-acetylhomoserine/O-acetylserine sulfhydrylase, pyridoxal phosphate-dependent is part of the Pathway/BioSystem: Methionine biosynthesis
Pssm-ID: 442120 [Multi-domain] Cd Length: 428 Bit Score: 345.86 E-value: 9.12e-117
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 1 MTRKQ---ATIAVRSGLNDDEQYGCVVPPIHLSSTYNFTGFNEPRA--------HDYSRRGNPTRDVVQRALAELEGGAG 69
Cdd:COG2873 1 MTEKKygfETLALHAGQEPDPTTGARAVPIYQTTSYVFDDAEHAADlfalkepgNIYTRIMNPTTDVLEKRIAALEGGVA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 70 AVLTNTGMSAILLVTTVFLKPGDLLVAPHDCYGGSYRLFD-SLAKRGcYRVLFVDQNDEQALSAALAEKPKLVLVESPSN 148
Cdd:COG2873 81 ALATASGQAAITLAILNLAEAGDHIVASSSLYGGTYNLFAhTLPRLG-IEVRFVDPDDPEAFEAAIDPNTKAIFGETIGN 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 149 PLLRVVDIAKICGLAREAGAVSVVDNTFLSPALQNPLALGADLVLHSCTKYLNGHSDVVAGVVI---------------- 212
Cdd:COG2873 160 PALDVLDIEAIAEIAHEHGVPLIVDNTFATPYLCRPIEHGADIVVHSATKYIGGHGTSIGGVIVdggnfdwaangkfpel 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 213 -AKDPA--------TVTELAW-------WANNIGVTGGAFDSYLLLRGLRTLSPRMEVAQRNALAIVDYLKSQPLVKKLY 276
Cdd:COG2873 240 tEPDPSyhglvyteAFGNAAFitkarvqLLRDLGAALSPFNAFLLLQGLETLSLRMERHVENALKVAEFLEAHPKVAWVN 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 277 HPSLPENQGHEIAARQ-QKGFGAMLSFELDGDEQTLRRFLSGLSLFTLAESLGGVESLISHAATMTHAGMAPEARAAAGI 355
Cdd:COG2873 320 YPGLPSHPYHELAQKYlPKGAGGVLTFGLKGGREAGKKFIDSLKLFSHLANIGDAKSLVIHPASTTHSQLSEEEQAAAGV 399
|
410 420
....*....|....*....|....*...
gi 503993435 356 SETLLRISTGIEDGEDLIADLENGFRAA 383
Cdd:COG2873 400 TPDLIRLSVGIEDIDDIIADLDQALAAA 427
|
|
| PRK07269 |
PRK07269 |
cystathionine gamma-synthase; Reviewed |
1-382 |
5.62e-116 |
|
cystathionine gamma-synthase; Reviewed
Pssm-ID: 235983 Cd Length: 364 Bit Score: 341.80 E-value: 5.62e-116
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 1 MTRKQATIAVRSGLNDDEQYGCVVPPIHLSSTYNFTGFNEPRAHDYSRRGNPTRDVVQRALAELEGGAGAVLTNTGMSAI 80
Cdd:PRK07269 3 KDLHINTILAQAGIKSDEATGALVTPLHFSTTYQHPEFGQSTGFDYTRTKNPTRAKLEETLAAIESADYALATSSGMSAI 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 81 LLVTTVFlkP-GDLLVAPHDCYGGSYRLFDSLAKRGcyRVLFVDQNDEQALSAALAEKPKLVLVESPSNPLLRVVDIAKI 159
Cdd:PRK07269 83 VLAFSVF--PvGSKVVAVRDLYGGSFRWFNQQEKEG--RFHFTYANTEEELIAAIEEDTDIVYIETPTNPLMVEFDIEKV 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 160 CGLAREAGAVSVVDNTFLSPALQNPLALGADLVLHSCTKYLNGHSDVVAGVVIAKDPATVTELAWWANNIGVTGGAFDSY 239
Cdd:PRK07269 159 AKLAHAKGAKVIVDNTFYSPIYQRPIELGADIVLHSATKYLSGHNDVLAGVVVTNDLELYEKLFYNLNTTGAVLSPFDSY 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 240 LLLRGLRTLSPRMEVAQRNALAIVDYLKSQPLVKKLYHPslpenqgheiaarqqkGFGAMLSFELdGDEQTLRRFLSGLS 319
Cdd:PRK07269 239 LLMRGLKTLSLRMERSTANAQEVVAFLKKSPAVKEVLYT----------------GKGGMISFKV-ADETRIPHILNSLK 301
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 503993435 320 LFTLAESLGGVESLISHAATMTHAGMAPEARAAAGISETLLRISTGIEDGEDLIADLENGFRA 382
Cdd:PRK07269 302 VFTFAESLGGVESLITYPTTQTHADIPAEVRHSYGLTDDLLRLSIGIEDARDLIADLKQALEG 364
|
|
| PRK08249 |
PRK08249 |
cystathionine gamma-synthase family protein; |
4-386 |
5.47e-115 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 236202 [Multi-domain] Cd Length: 398 Bit Score: 340.56 E-value: 5.47e-115
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 4 KQATIAVRSGLNDDEQYGCVVPPIHLSSTYNFTGFNE--------PRAHDYSRRGNPTRDVVQRALAELEGGAGAVLTNT 75
Cdd:PRK08249 8 GVGTKAVWAGEKEYLPYGATQVPVVLSVAYGYDDIDEwydvalgkKPGHIYSRNTNPTVQAFEEKVRILEGAEAATAFST 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 76 GMSAILLVTTVFLKPGDLLVAPHDCYGGSYRLFDSLAKRGCYRVLFVDQNDEQALSAALAEKPKLVLVESPSNPLLRVVD 155
Cdd:PRK08249 88 GMAAISNTLYTFLKPGDRVVSIKDTYGGTNKIFTEFLPRMGVDVTLCETGDHEQIEAEIAKGCDLLYLETPTNPTLKIVD 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 156 IAKICGLAREAGAVSVVDNTFLSPALQNPLALGADLVLHSCTKYLNGHSDVVAGVVIAkDPATVTELAWWANNIGVTGGA 235
Cdd:PRK08249 168 IERLAAAAKKVGALVVVDNTFATPINQNPLALGADLVIHSATKFLSGHADALGGVVCG-SKELMEQVYHYREINGATMDP 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 236 FDSYLLLRGLRTLSPRMEVAQRNALAIVDYLKSQPLVKKLYHPSLPENQGHEIAARQQKGFGAMLSFELDGDEQTLRRFL 315
Cdd:PRK08249 247 MSAYLILRGMKTLKLRVRQQQESAMALAKYLQTHPKVEAVYYPGLETHPNHEIAKAQMRGFGGILSFVLKGGMDTVKRLL 326
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 503993435 316 SGLSLFTLAESLGGVESLISHAATMTHAGMAPEARAAAGISETLLRISTGIEDGEDLIADLENGFRAANEE 386
Cdd:PRK08249 327 PKLRYAHRAANLGAVETIYGPARTTSHVENTLEERAALGIPEGLVRISVGIEDTEDLIADLEQAFAHLESE 397
|
|
| met_gam_lyase |
TIGR01328 |
methionine gamma-lyase; This model describes a methionine gamma-lyase subset of a family of ... |
6-382 |
2.43e-111 |
|
methionine gamma-lyase; This model describes a methionine gamma-lyase subset of a family of PLP-dependent trans-sulfuration enzymes. The member from the parasite Trichomonas vaginalis is described as catalyzing alpha gamma- and alpha-beta eliminations and gamma-replacement reactions on methionine, cysteine, and some derivatives. Likewise, the enzyme from Pseudomonas degrades cysteine as well as methionine. [Energy metabolism, Amino acids and amines]
Pssm-ID: 130395 [Multi-domain] Cd Length: 391 Bit Score: 331.08 E-value: 2.43e-111
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 6 ATIAVRSGLNDDEQYGCVVPPIHLSSTYNF----TGFN----EPRAHDYSRRGNPTRDVVQRALAELEGGAGAVLTNTGM 77
Cdd:TIGR01328 5 ATRAIHAGYPPKDQFGALTPPIYQTSTFVFdsceQGGNrfagQESGYIYSRLGNPTVSNLEGRIAFLEGTEAAVATSSGM 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 78 SAILLVTTVFLKPGDLLVAPHDCYGGSYRLFDSLAKRGCYRVLFVDQNDEQALSAALAEKPKLVLVESPSNPLLRVVDIA 157
Cdd:TIGR01328 85 GAIAATLLTILKAGDHLISDECLYGCTFALLEHALTKFGIQVDFINMAIPEEVKAHIKDNTKIVYFETPANPTMKLIDME 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 158 KICGLAREAGAVSVVDNTFLSPALQNPLALGADLVLHSCTKYLNGHSDVVAGVVIAK-DPATVTELAWWANNIGVTGGAF 236
Cdd:TIGR01328 165 RVCRDAHSQGVKVIVDNTFATPMLTNPVALGVDVVVHSATKYIGGHGDVVAGLICGKaELLQQIRMVGIKDMTGSVISPF 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 237 DSYLLLRGLRTLSPRMEVAQRNALAIVDYLKSQPLVKKLYHPSLPENQGHEIAARQQKGFGAMLSFELDGDEQTLRRFLS 316
Cdd:TIGR01328 245 DAWLILRGLKTLNIRMKRHSENAMKVAEYLKSHPAVEKVYYPGFEDHPGHDIAAKQMRMGGGMITFELKGGFAGAKKLLN 324
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 503993435 317 GLSLFTLAESLGGVESLISHAATMTHAGMAPEARAAAGISETLLRISTGIEDGEDLIADLENGFRA 382
Cdd:TIGR01328 325 NLKLIRLAVSLGDAETLIQHPASMTHAVVPKEEREAAGITDGMIRLSVGLEDADDLIADLKQALDA 390
|
|
| PRK08133 |
PRK08133 |
O-succinylhomoserine sulfhydrylase; Validated |
6-382 |
8.14e-111 |
|
O-succinylhomoserine sulfhydrylase; Validated
Pssm-ID: 181244 [Multi-domain] Cd Length: 390 Bit Score: 329.65 E-value: 8.14e-111
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 6 ATIAVRSGLNDdEQYGCVVPPIHLSSTYNFT-------GF-NEPRAHDYSRRGNPTRDVVQRALAELEGGAGAVLTNTGM 77
Cdd:PRK08133 8 DTLAVRAGQLR-SPFGEHSEALFLTSSFVFEsaaeaaaRFaGEEPGNIYSRFTNPTVTMFQERLAALEGAEACVATASGM 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 78 SAILLVTTVFLKPGDLLVAPHDCYGGSYRLFDSLAKRGCYRVLFVDQNDEQALSAALAEKPKLVLVESPSNPLLRVVDIA 157
Cdd:PRK08133 87 AAILAVVMALLQAGDHVVSSRSLFGSTVSLFEKIFARFGIETTFVDLTDLDAWRAAVRPNTKLFFLETPSNPLTELADIA 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 158 KICGLAREAGAVSVVDNTFLSPALQNPLALGADLVLHSCTKYLNGHSDVVAGVVIAKDpATVTELAWWANNIGVTGGAFD 237
Cdd:PRK08133 167 ALAEIAHAAGALLVVDNCFCTPALQQPLKLGADVVIHSATKYLDGQGRVLGGAVVGSK-ELMEEVFGFLRTAGPTLSPFN 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 238 SYLLLRGLRTLSPRMEVAQRNALAIVDYLKSQPLVKKLYHPSLPENQGHEIAARQQKGFGAMLSFELDGDEQTLRRFLSG 317
Cdd:PRK08133 246 AWVFLKGLETLSLRMEAHSANALALAEWLEAHPGVERVFYPGLPSHPQHELAKRQQKGGGAIVSFEVKGGREAAWRVIDA 325
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 503993435 318 LSLFTLAESLGGVESLISHAATMTHAGMAPEARAAAGISETLLRISTGIEDGEDLIADLENGFRA 382
Cdd:PRK08133 326 TRLISITANLGDTKTTITHPATTTHGRLSPEARAAAGITEGLIRVAVGLEDVADIKADLARGLAA 390
|
|
| PRK07503 |
PRK07503 |
methionine gamma-lyase; Provisional |
6-383 |
3.65e-108 |
|
methionine gamma-lyase; Provisional
Pssm-ID: 181005 [Multi-domain] Cd Length: 403 Bit Score: 323.29 E-value: 3.65e-108
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 6 ATIAVRSGLNDDEQYGCVVPPIHLSSTYNFTGFN--------EPRAHDYSRRGNPTRDVVQRALAELEGGAGAVLTNTGM 77
Cdd:PRK07503 11 STRAIHHGYDPLDHGGALVPPVYLTATFAFPTAEygaecfagEEEGHFYSRISNPTLALLEQRMASLEGGEAAVALASGM 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 78 SAILLVTTVFLKPGDLLVAPHDCYGGSYR-LFDSLAKRGCyRVLFVDQNDEQALSAALAEKPKLVLVESPSNPLLRVVDI 156
Cdd:PRK07503 91 GAITATLWTLLRPGDEVIVDQTLYGCTFAfLHHGLGEFGV-TVRHVDLTDPAALKAAISDKTRMVYFETPANPNMRLVDI 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 157 AKICGLAREAGAVSVVDNTFLSPALQNPLALGADLVLHSCTKYLNGHSDVVAGVVIA-KDPATVTELAWWANNIGVTGGA 235
Cdd:PRK07503 170 AAVAEIAHGAGAKVVVDNTYCTPYLQRPLELGADLVVHSATKYLGGHGDITAGLVVGgKALADRIRLEGLKDMTGAVMSP 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 236 FDSYLLLRGLRTLSPRMEVAQRNALAIVDYLKSQPLVKKLYHPSLPENQGHEIAARQQKGFGAMLSFELDGDEQTLRRFL 315
Cdd:PRK07503 250 FDAFLLMRGLKTLALRMDRHCASAQAVAEWLARHPAVELVHYPGLPSFAQHALAQRQMALPGGMIAFELKGGIAAGRRFM 329
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 503993435 316 SGLSLFTLAESLGGVESLISHAATMTHAGMAPEARAAAGISETLLRISTGIEDGEDLIADLENGFRAA 383
Cdd:PRK07503 330 NALQLFARAVSLGDAESLAQHPASMTHSTYTPEERAEHGISEGLVRLSVGLEDVADILADLAQALDAC 397
|
|
| PRK06234 |
PRK06234 |
methionine gamma-lyase; Provisional |
6-379 |
5.36e-107 |
|
methionine gamma-lyase; Provisional
Pssm-ID: 168478 [Multi-domain] Cd Length: 400 Bit Score: 320.24 E-value: 5.36e-107
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 6 ATIAVRSGLNDDEQYGCVVPPIHLSSTYNFTGFN--------EPRAHDYSRRGNPTRDVVQRALAELEGGAGAVLTNTGM 77
Cdd:PRK06234 10 ATKAIHGGHIGDKQFGSLATPIYQTSTFIFDSAEqggrrfagEESGYIYSRLGNPTSTEVENKLALLEGGEAAVVAASGM 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 78 SAILLVTTVFLKPGDLLVAPHDCYGGSYRLFDSLAKRGCYRVLFVDQNDEQALSAALAEKPKLVLVESPSNPLLRVVDIA 157
Cdd:PRK06234 90 GAISSSLWSALKAGDHVVASDTLYGCTFALLNHGLTRYGVEVTFVDTSNLEEVRNALKANTKVVYLETPANPTLKVTDIK 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 158 KICGLAREA--GAVSVVDNTFLSPALQNPLALGADLVLHSCTKYLNGHSDVVAGVVIAK-DPATVTELAWWANNIGVTGG 234
Cdd:PRK06234 170 AISNIAHENnkECLVFVDNTFCTPYIQRPLQLGADVVVHSATKYLNGHGDVIAGFVVGKeEFINQVKLFGIKDMTGSVIG 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 235 AFDSYLLLRGLRTLSPRMEVAQRNALAIVDYLKSQPLVKKLYHPSLPENQGHEIAARQQKGFGAMLSFELDGDEQTLRRF 314
Cdd:PRK06234 250 PFEAFLIIRGMKTLQIRMEKHCKNAMKVAKFLESHPAVEKVYYPGLESFEYYELAKKQMSLPGAMISFELKGGVEEGKVV 329
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 503993435 315 LSGLSLFTLAESLGGVESLISHAATMTHAGMAPEARAAAGISETLLRISTGIEDGEDLIADLENG 379
Cdd:PRK06234 330 MNNVKLATLAVSLGDAETLIQHPASMTHSPYTAEERKEAGISDGLVRLSVGLEDVDDIIADLKQA 394
|
|
| PRK08574 |
PRK08574 |
cystathionine gamma-synthase family protein; |
4-382 |
1.22e-106 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 236298 [Multi-domain] Cd Length: 385 Bit Score: 318.93 E-value: 1.22e-106
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 4 KQATIAVRSGLNDDeQYGCVVPPIHLSSTYNFTGFNEP--RAHD--YSRRGNPTRDVVQRALAELEGGAGAVLTNTGMSA 79
Cdd:PRK08574 2 RRGTDAVRGYRGSD-PYGSLQPPIYLTALFRQEGEAYPsdRGFDlkYSREENPTLRPLEEALAKLEGGVDALAFNSGMAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 80 ILLVTTVFLKPGDLLVAPHDCYGGSYRLFDSLAKRGcYRVLFVDQNDEQALSAALAEKPKLVLVESPSNPLLRVVDIAKI 159
Cdd:PRK08574 81 ISTLFFSLLKAGDRVVLPMEAYGTTLRLLKSLEKFG-VKVVLAYPSTEDIIEAIKEGRTKLVFIETMTNPTLKVIDVPEV 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 160 CGLAREAGAVSVVDNTFLSPALQNPLALGADLVLHSCTKYLNGHSDVVAGVVIAKDPATVTELAWWANNIGVTGGAFDSY 239
Cdd:PRK08574 160 AKAAKELGAILVVDNTFATPLLYRPLRHGADFVVHSLTKYIAGHNDVVGGVAVAWSGEFLEELWEWRRRLGTIMQPFEAY 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 240 LLLRGLRTLSPRMEVAQRNALAIVDYLKSQPLVKKLYHPSLPENQGHEIAAR--QQKGFGAMLSFELDGDEQTLRRFLSG 317
Cdd:PRK08574 240 LVLRGLKTLEVRFERQCRNAMAIAEFLSEHPKVAEVYYPGLPSDPYHGVAKRlfGKDLYGGVVSFRVKGGRDAVLKFLRS 319
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 503993435 318 LSLFTLAESLGGVESLISHAATMTHAGMAPEARAAAGISETLLRISTGIEDGEDLIADLENGFRA 382
Cdd:PRK08574 320 LKLIKPSPSLGGVESLATYPVKSAASPIPEEDRKALGITEDLVRLSVGLEDVEDLIEDLDQALGS 384
|
|
| PRK06767 |
PRK06767 |
methionine gamma-lyase; Provisional |
7-377 |
3.78e-97 |
|
methionine gamma-lyase; Provisional
Pssm-ID: 180685 [Multi-domain] Cd Length: 386 Bit Score: 294.44 E-value: 3.78e-97
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 7 TIAVRSGLNDDEQYGCVVPPIHLSSTYNFT----GFNEPRAHD----YSRRGNPTRDVVQRALAELEGGAGAVLTNTGMS 78
Cdd:PRK06767 8 TALIHHGYTSEEHKGSLTPPLFQTSTFTFEtaqqGEASFAGVDpsyiYSRLGNPTVKLFEERMAVLEGGEEALAFGSGMA 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 79 AILLVTTVFLKPGDLLVAPHDCYGGSYRLFDSLAKRGCYRVLFVDQNDEQALSAALAEKPKLVLVESPSNPLLRVVDIAK 158
Cdd:PRK06767 88 AISATLIGFLKAGDHIICSNGLYGCTYGFLEVLEEKFMITHSFCDMETEADIENKIRPNTKLIFVETPINPTMKLIDLKQ 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 159 ICGLAREAGAVSVVDNTFLSPALQNPLALGADLVLHSCTKYLNGHSDVVAGVVIAKDPATVTELAWWANNIGVTGGAFDS 238
Cdd:PRK06767 168 VIRVAKRNGLLVIVDNTFCSPYLQRPLELGCDAVVHSATKYIGGHGDVVAGVTICKTRALAEKIRPMRKDIGGIMAPFDA 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 239 YLLLRGLRTLSPRMEVAQRNALAIVDYLKSQPLVKKLYHPSlpenqgHEIAARQQKGFGAMLSFELDGDEQTLRRFLSGL 318
Cdd:PRK06767 248 WLLLRGLKTLAVRMDRHCDNAEKIVSFLKNHDAVEGVWYPE------GELASRQMKRGGGVISFSIKGGKEETQAFINDL 321
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 503993435 319 SLFTLAESLGGVESLISHAATMTHAGMAPEARAAAGISETLLRISTGIEDGEDLIADLE 377
Cdd:PRK06767 322 HFITIAVSLGDTETLIQHPATMTHAAIPAELRQEMGIYDNLIRLSVGLESWEDIVSDLE 380
|
|
| PRK06460 |
PRK06460 |
hypothetical protein; Provisional |
4-377 |
7.23e-97 |
|
hypothetical protein; Provisional
Pssm-ID: 235807 [Multi-domain] Cd Length: 376 Bit Score: 293.66 E-value: 7.23e-97
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 4 KQATIAVRSGLndDEQYGCVVPPIHLSSTYNFTGFNEPRahdYSRRGNPTRDVVQRALAELEGGAGAVLTNTGMSAILLV 83
Cdd:PRK06460 2 KDATRTVREDI--DEATGAITTPIYQTTAYHYPEGEKYR---YSREANPTVLELTKKIVELENAEMGVAFSSGMGAISTT 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 84 TTVFLKPGDLLVAPHDCYGGSYRLFDSLAKRGCYRVLFVDQNDEQALSAALAEKPKLVLVESPSNPLLRVVDIAKICGLA 163
Cdd:PRK06460 77 ALALLKPGNSVLVHRDMFGRSYRFFTDYLKNWGVNVDASNPGSDNIIEKAKSKRYDVVFVENITNPLLRVVDITELSKVC 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 164 REAGAVSVVDNTFLSPALQNPLALGADLVLHSCTKYLNGHSDVVAGVvIAKDPATVTELAWWANNIGVTGGAFDSYLLLR 243
Cdd:PRK06460 157 KENGSILIVDATFSTPINQKPLELGADIVVHSASKFLAGHNDVIAGL-AAGYGKLLNVIDQMRRTLGTSLDPHAAYLTLR 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 244 GLRTLSPRMEVAQRNALAIVDYLKSQPLVKKLYHPSLPENQGHEIAARQQKGFGAMLSFELDGDEQTLRRFLSGLSLFTL 323
Cdd:PRK06460 236 GIKTLKIRMDVINRNAEQIAEFLEGHPKVVKVYYPGLKSHVDYEIARRVLKGFGGVLSFEVNGGQESALKVMKSLKLIIP 315
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 503993435 324 AESLGGVESLISHAATMTHAGMAPEARAAAGISETLLRISTGIEDGEDLIADLE 377
Cdd:PRK06460 316 AQTLGGVNSVISHPATMSHRTLSLEERKIVGITDSLLRLSVGIEDVNDLIEDLD 369
|
|
| PLN02509 |
PLN02509 |
cystathionine beta-lyase |
15-381 |
3.24e-96 |
|
cystathionine beta-lyase
Pssm-ID: 178125 [Multi-domain] Cd Length: 464 Bit Score: 295.01 E-value: 3.24e-96
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 15 NDDEQYGCVVPPIHLSSTYNFTGFNEPRAHDYSRRGNPTRDVVQRALAELEGGAGAVLTNTGMSAILLVTTVfLKPGDLL 94
Cdd:PLN02509 96 NKFDPFDAMSTPLYQTATFKQPSAIENGPYDYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAALSAVTHL-IKNGEEI 174
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 95 VAPHDCYGGSYRLFDSLAKRGCYRVLFVDQNDEQALSAALAEKPKLVLVESPSNPLLRVVDIAKICGLAREAGAVSVVDN 174
Cdd:PLN02509 175 VAGDDVYGGSDRLLSQVVPRSGVVVKRVNTTNLDEVAAAIGPQTKLVWLESPTNPRQQISDIRKIAEMAHAQGALVLVDN 254
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 175 TFLSPALQNPLALGADLVLHSCTKYLNGHSDVVAGVVIAKDPATVTELAWWANNIGVTGGAFDSYLLLRGLRTLSPRMEV 254
Cdd:PLN02509 255 SIMSPVLSRPLELGADIVMHSATKFIAGHSDVMAGVLAVKGEKLAKEVYFLQNSEGSGLAPFDCWLCLRGIKTMALRIEK 334
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 255 AQRNALAIVDYLKSQPLVKKLYHPSLPENQGHEIAARQQKGFGAMLSFeLDGDEQTLRRFLSGLSLFTLAESLGGVESLI 334
Cdd:PLN02509 335 QQENARKIAMYLSSHPRVKKVYYAGLPDHPGHHLHFSQAKGAGSVFSF-ITGSVALSKHLVETTKYFSIAVSFGSVKSLI 413
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 503993435 335 SHAATMTHAGMAPEARAAAGISETLLRISTGIEDGEDLIADLENGFR 381
Cdd:PLN02509 414 SMPCFMSHASIPAEVREARGLTEDLVRISAGIEDVDDLISDLDIAFR 460
|
|
| O_suc_HS_sulf |
TIGR01325 |
O-succinylhomoserine sulfhydrylase; This model describes O-succinylhomoserine sulfhydrylase, ... |
6-379 |
2.16e-95 |
|
O-succinylhomoserine sulfhydrylase; This model describes O-succinylhomoserine sulfhydrylase, one of several related pyridoxal phosphate-dependent enzymes of cysteine and methionine metabolism. This enzyme is part of an alternative pathway of homocysteine biosynthesis, a step in methionine biosynthesis. [Amino acid biosynthesis, Aspartate family]
Pssm-ID: 188131 Cd Length: 381 Bit Score: 289.82 E-value: 2.16e-95
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 6 ATIAVRSGLnDDEQYGCVVPPIHLSSTY----------NFTGfnEPRAHDYSRRGNPTRDVVQRALAELEGGAGAVLTNT 75
Cdd:TIGR01325 1 ATLAVRGGM-LRSGFEETAEALYLTSGYvydsaavaakRFAG--ELPGFVYSRYGNPTVSVFEERLALLEGAEAAVATAS 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 76 GMSAILLVTTVFLKPGDLLVAPHDCYGGSYRLFDSLAKRGCYRVLFVDQNDEQALSAALAEKPKLVLVESPSNPLLRVVD 155
Cdd:TIGR01325 78 GMAAIFAALMALLGAGDHVVASRSLFGSCFVVCSEILPRFGVQTVFVDGTDLSAWEAALKPNTKAVFVETPSNPLQELVD 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 156 IAKICGLAREAGAVSVVDNTFLSPALQNPLALGADLVLHSCTKYLNGHSDVVAGVVIAKDPATVTELAWWANNIGVTGGA 235
Cdd:TIGR01325 158 IAAVAELAHAAGAKVVVDNVFATPLLQQPLKLGADVVVYSATKHIDGQGRVLGGAILGSEEYMDEPVQKLLRHTGPAMSP 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 236 FDSYLLLRGLRTLSPRMEVAQRNALAIVDYLKSQPLVKKLYHPSLPENQGHEIAARQQKGFGAMLSFELDGDEQTLrRFL 315
Cdd:TIGR01325 238 FNAWVLLKGLETLAIRVQHQNASALAIAEWLNGHPSVQWVYYPGLPSHPQHELAKRQMSGGGTVVTFDLDCRQAAF-KVL 316
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 503993435 316 SGLSLFTLAESLGGVESLISHAATMTHAGMAPEARAAAGISETLLRISTGIEDGEDLIADLENG 379
Cdd:TIGR01325 317 DAMRLVDISNNLGDAKSTITHPATTTHRRMGPEERAAAGIGDGLVRLSVGLEDVDDLIADIDRA 380
|
|
| OAH_OAS_sulfhy |
TIGR01326 |
OAH/OAS sulfhydrylase; This model describes a distinct clade of the Cys/Met metabolism ... |
6-380 |
5.76e-93 |
|
OAH/OAS sulfhydrylase; This model describes a distinct clade of the Cys/Met metabolism pyridoxal phosphate-dependent enzyme superfamily. Members include examples of OAH/OAS sulfhydrylase, an enzyme with activity both as O-acetylhomoserine (OAH) sulfhydrylase (EC 2.5.1.49) and O-acetylserine (OAS) sulphydrylase (EC 2.5.1.47). An alternate name for OAH sulfhydrylase is homocysteine synthase. This model is designated subfamily because it may or may not have both activities. [Amino acid biosynthesis, Aspartate family, Amino acid biosynthesis, Serine family]
Pssm-ID: 273555 [Multi-domain] Cd Length: 418 Bit Score: 285.02 E-value: 5.76e-93
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 6 ATIAVRSGLNDDEQYGCVVPPIHLSSTYNFT---------GFNEPrAHDYSRRGNPTRDVVQRALAELEGGAGAVLTNTG 76
Cdd:TIGR01326 3 ETLQLHAGQEPDPTTGSRAVPIYQTTSYVFDstehaaalfGLQEP-GNIYSRLMNPTTDVLEQRIAALEGGVAALAVASG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 77 MSAILLVTTVFLKPGDLLVAPHDCYGGSYRLFDSLAKRGCYRVLFVDQNDEQALSAALAEKPKLVLVESPSNPLLRVVDI 156
Cdd:TIGR01326 82 QAAITYAILNLAGAGDNIVSSSYLYGGTYNLFSHTLKRLGIEVRFVDPDDPESLEKAIDENTKAVFAETIGNPQINVLDI 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 157 AKICGLAREAGAVSVVDNTFLSPALQNPLALGADLVLHSCTKYLNGHSDVVAGVVI----------------AKDPA--- 217
Cdd:TIGR01326 162 EAIAEVAHRHGIPLIVDNTFATPYLCRPIKHGADIVVHSATKYIGGHGTAIGGVIVdggkfdwnngrfplftTPDPSyhg 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 218 -----TVTELAW-------WANNIGVTGGAFDSYLLLRGLRTLSPRMEVAQRNALAIVDYLKSQPLVKKLYHPSLPENQG 285
Cdd:TIGR01326 242 lvfteTLGNPAFilkarvqLLRDLGAALSPFNAFLLLQGLETLSLRMERHVENALKVAEFLESHPDVAWVNYPGLASHPH 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 286 HEIAAR-QQKGFGAMLSFELDGDEQTLRRFLSGLSLFTLAESLGGVESLISHAATMTHAGMAPEARAAAGISETLLRIST 364
Cdd:TIGR01326 322 HALAKKyLPKGFGAVLSFEIKGGREAGKKFIDALKLASHLANVGDAKSLVIHPASTTHSQLSEEEQLKAGVTPGLIRLSV 401
|
410
....*....|....*.
gi 503993435 365 GIEDGEDLIADLENGF 380
Cdd:TIGR01326 402 GIENIDDIIADLEQAL 417
|
|
| PRK07049 |
PRK07049 |
cystathionine gamma-synthase family protein; |
21-383 |
2.02e-92 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 180809 [Multi-domain] Cd Length: 427 Bit Score: 283.87 E-value: 2.02e-92
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 21 GCVVPPIHLSSTYNF-------------TGFNEPRAHD-----YSRRGNPTRDVVQRALAELEGGAGAVLTNTGMSAILL 82
Cdd:PRK07049 34 GAVKPPVFLTSTFVFrsaedgrdffdyvSGRKEPPAGEgaglvYSRFNHPNSEIVEDRLAVYEGAESAALFSSGMSAIAT 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 83 VTTVFLKPGDLLVAPHDCYGGSYRLF-DSLAKRGCYRVLFVDQNDEQALSAALAE-----KPKLVLVESPSNPLLRVVDI 156
Cdd:PRK07049 114 TLLAFVRPGDVILHSQPLYGGTETLLaKTFRNFGVGAVGFADGLSEAAIGAAAEAaaakgRVSLILIETPANPTNSLVDV 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 157 AKICGLAREAGA------VSVVDNTFLSPALQNPLALGADLVLHSCTKYLNGHSDVVAGVVIAKDpATVTELAWWANNIG 230
Cdd:PRK07049 194 AAVRRVADAIEArqghrpIIACDNTLLGPVFQKPLEHGADLSVYSLTKYVGGHSDLVAGAVLGRK-ALIRQVRALRSAIG 272
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 231 VTGGAFDSYLLLRGLRTLSPRMEVAQRNALAIVDYLKSQPLVKKL-YHPSL-PENQGHEIAARQQKGFGAMLSFELDGDE 308
Cdd:PRK07049 273 TQLDPHSCWMLGRSLETLVLRMERANRNARAVAEFLRDHPKVEKLhYLPFLdPDSAYGAVYKRQCTGAGSTFSFDIKGGQ 352
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 503993435 309 QTLRRFLSGLSLFTLAESLGGVESLISHAATMTHAGMAPEARAAAGISETLLRISTGIEDGEDLIADLENGFRAA 383
Cdd:PRK07049 353 AAAFRFLNALQIFKLAVSLGGTESLASHPASMTHSGVPADVRERIGVLESTIRLSIGIEHPDDLIADLAQALDAA 427
|
|
| PRK07582 |
PRK07582 |
cystathionine gamma-lyase; Validated |
6-383 |
5.63e-87 |
|
cystathionine gamma-lyase; Validated
Pssm-ID: 236061 Cd Length: 366 Bit Score: 267.63 E-value: 5.63e-87
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 6 ATIAVRSGLNDDEQYGCVVPPIHLSSTYNFTGFNEPRAHDYSRRGNPTRDVVQRALAELEGGaGAVLTNTGMSAILLVTT 85
Cdd:PRK07582 5 GTRSVHAGGPEAVPGEPVLPGPVFAAPYHLSPGEPTGPDTYGRASNPTWRALEAALGELEGA-EALVFPSGMAAITAVLR 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 86 VFLKPGDLLVAPHDCYGGSYRLF-DSLAKRGcyrvLFVDQNDEQALSAALAEKPKLVLVESPSNPLLRVVDIAKICGLAR 164
Cdd:PRK07582 84 ALLRPGDTVVVPADGYYQVRALArEYLAPLG----VTVREAPTAGMAEAALAGADLVLAETPSNPGLDVCDLAALAAAAH 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 165 EAGAVSVVDNTFLSPALQNPLALGADLVLHSCTKYLNGHSDVVAGVVIAKDPATVTELAWWANNIGVTGGAFDSYLLLRG 244
Cdd:PRK07582 160 AAGALLVVDNTTATPLGQRPLELGADLVVASDTKALTGHSDLLLGYVAGRDPELMAAVERWRLLAGAIPGPFEAWLAHRS 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 245 LRTLSPRMEVAQRNALAIVDYLKSQPLVKKLYHPSLPENQGHEIAARQQKGFGAMLSFELdGDEQTLRRFLSGLSLFTLA 324
Cdd:PRK07582 240 LGTLGLRFARQCANALAVAELLAGHPAVRGVRYPGLPGDPAHEVAARQMRRFGGLVSFEL-ADAAAAERFVAASRLVVAA 318
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 503993435 325 ESLGGVESlishaatmthagmAPEARAAAG--ISETLLRISTGIEDGEDLIADLENGFRAA 383
Cdd:PRK07582 319 TSFGGVHT-------------SADRRARWGdaVPEGFVRLSCGIEDTDDLVADLERALDAL 366
|
|
| PRK07810 |
PRK07810 |
O-succinylhomoserine sulfhydrylase; Provisional |
5-377 |
1.30e-85 |
|
O-succinylhomoserine sulfhydrylase; Provisional
Pssm-ID: 236103 [Multi-domain] Cd Length: 403 Bit Score: 265.44 E-value: 1.30e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 5 QATIAVRSGLnDDEQYGCVVPPIHLSSTY----------NFTGfnEPRAHDYSRRGNPTRDVVQRALAELEGGAGAVLTN 74
Cdd:PRK07810 16 QATIGVRGGL-LRSGFEETAEALYLTSGYvyesaaaaeaAFTG--ELDRFVYSRYGNPTVSMFEERLRLIEGAEACFATA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 75 TGMSAILLVTTVFLKPGDLLVAPHDCYGGSYRLFDSLAKRGCYRVLFVDQNDEQALSAALAEKPKLVLVESPSNPLLRVV 154
Cdd:PRK07810 93 SGMSAVFTALGALLGAGDRLVAARSLFGSCFVVCNEILPRWGVETVFVDGEDLSQWEEALSVPTQAVFFETPSNPMQSLV 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 155 DIAKICGLAREAGAVSVVDNTFLSPALQNPLALGADLVLHSCTKYLNGHSDVVAGVVI-AKD--PATVTELawwANNIGV 231
Cdd:PRK07810 173 DIAAVSELAHAAGAKVVLDNVFATPLLQRGLPLGADVVVYSGTKHIDGQGRVLGGAILgDREyiDGPVQKL---MRHTGP 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 232 TGGAFDSYLLLRGLRTLSPRMEVAQRNALAIVDYLKSQPLVKKLYHPSLPENQGHEIAARQQKGFGAMLSFELDGDEQTL 311
Cdd:PRK07810 250 ALSAFNAWVLLKGLETLALRVRHSNASALRIAEFLEGHPAVRWVRYPFLPSHPQYDLAKRQMSGGGTVVTFELDAPEDAA 329
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 312 RR----FLSGLSLFTLAESLGGVESLISHAATMTHAGMAPEARAAAGISETLLRISTGIEDGEDLIADLE 377
Cdd:PRK07810 330 KKrafeVLDKLRVIDISNNLGDAKSLITHPATTTHRAMGPEGRAAIGLGDGVVRLSVGLEDTDDLIADLD 399
|
|
| PRK06434 |
PRK06434 |
cystathionine gamma-lyase; Validated |
7-382 |
7.85e-84 |
|
cystathionine gamma-lyase; Validated
Pssm-ID: 102374 [Multi-domain] Cd Length: 384 Bit Score: 260.22 E-value: 7.85e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 7 TIAVRSGLNDDEQYGCVVPPIHLSSTYNFTGFNEPRAHD--------YSRRGNPTRDVVQRALAELEGGAGAVLTNTGMS 78
Cdd:PRK06434 11 TRAVQSGELRDPRFGNVTTPIFETSTFVYPNSEKEAYMDstrgmpyiYTRWGNPTVQAFEEKYAVLENAEHALSFSSGMG 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 79 AILLVTTVFLKPGDLLVAPHDCYGGSYRLFDSLAKRGCYRVLFVDQNDEQALSAAlAEKPKLVLVESPSNPLLRVVDIAK 158
Cdd:PRK06434 91 AITSAILSLIKKGKRILSISDLYGQTFYFFNKVLKTLGIHVDYIDTDRLNSLDFD-PSNYDLIYAESITNPTLKVPDIKN 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 159 ICGLAREAGAVsvVDNTFLSPALQNPLALGADLVLHSCTKYLNGHSDVVAGVVIAKDPATVTELAWWANNIGVTGGAFDS 238
Cdd:PRK06434 170 VSSFCHENDVI--VDATFASPYNQNPLDLGADVVIHSATKYISGHSDVVMGVAGTNNKSIFNNLVERRKTLGSNPDPIQA 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 239 YLLLRGLRTLSPRMEVAQRNALAIVDYLKSQPLVKKLYHPSLpenqghEIAARQQKGFGAMLSFELDGDEQtLRRFLSGL 318
Cdd:PRK06434 248 YLALRGLKTLGLRMEKHNKNGMELARFLRDSKKISNVYYPDT------EIGKKVLRGFGGMLSFELRSMED-VHKFIRNL 320
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 503993435 319 SLFTLAESLGGVESLISHAATMTHAGMAPEARAAAGISETLLRISTGIEDGEDLIADLENGFRA 382
Cdd:PRK06434 321 EIPMVAASLGGVESLITLPVETSHSSLSPEERERLGISDNLVRFSIGIEDIDDLIKDIENALSK 384
|
|
| PRK08134 |
PRK08134 |
O-acetylhomoserine aminocarboxypropyltransferase; Validated |
7-383 |
3.83e-83 |
|
O-acetylhomoserine aminocarboxypropyltransferase; Validated
Pssm-ID: 236159 Cd Length: 433 Bit Score: 260.06 E-value: 3.83e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 7 TIAVRSGLNDDEQYGCVVPPIHLSSTYNFTG-------FNEPRA-HDYSRRGNPTRDVVQRALAELEGGAGAVLTNTGMS 78
Cdd:PRK08134 11 TLALHAGAAPDPATGARAVPIHLTTSFVFRDsdhaaalFNLERAgHVYSRISNPTVAVLEERVAALEGGVGAIATASGQA 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 79 AILLVTTVFLKPGDLLVAPHDCYGGSYRLFDSLAKRGCYRVLFVDQNDEQALSAALAEKPKLVLVESPSNPLLRVVDIAK 158
Cdd:PRK08134 91 ALHLAIATLMGAGSHIVASSALYGGSHNLLHYTLRRFGIETTFVKPGDIDGWRAAIRPNTRLLFGETLGNPGLEVLDIPT 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 159 ICGLAREAGAVSVVDNTFLSPALQNPLALGADLVLHSCTKYLNGHSDVVAGVVI---------AKDPATVTELAWWANNI 229
Cdd:PRK08134 171 VAAIAHEAGVPLLVDSTFTTPYLLRPFEHGADLVYHSATKFLGGHGTAIGGVLVdggrfdweaSGKFPELTEPYAGFHGM 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 230 ----GVTGGAF-------------------DSYLLLRGLRTLSPRMEVAQRNALAIVDYLKSQPLVKKLYHPSLPENQGH 286
Cdd:PRK08134 251 vfaeESTVAAFllrarreglrdfgaclspmNAWQLLQGIETLPLRMERHVANTRKVVAFLASHPAVARVAHPELESHPDH 330
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 287 EIAAR-QQKGFGAMLSFELDGDEQTLRRFLSGLSLFTLAESLGGVESLISHAATMTHAGMAPEARAAAGISETLLRISTG 365
Cdd:PRK08134 331 ALAKRlLPRGAGSVFSFDLKGGRAAGRKFIESLKLFSHLANVGDARSLVIHPASTTHFRMDAAALAAAGIGEGTIRLSIG 410
|
410
....*....|....*...
gi 503993435 366 IEDGEDLIADLENGFRAA 383
Cdd:PRK08134 411 LEDADDLIDDLKRALKAA 428
|
|
| PRK07812 |
PRK07812 |
O-acetylhomoserine aminocarboxypropyltransferase; Validated |
7-383 |
2.87e-80 |
|
O-acetylhomoserine aminocarboxypropyltransferase; Validated
Pssm-ID: 236105 Cd Length: 436 Bit Score: 252.75 E-value: 2.87e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 7 TIAVRSGLNDDEQYGCVVPPIHLSSTYNFT---------GFNEPrAHDYSRRGNPTRDVVQRALAELEGGAGAVLTNTGM 77
Cdd:PRK07812 16 TKQIHAGQTPDPATNARALPIYQTTSYTFDdtdhaaalfGLAEP-GNIYTRIMNPTQDVVEQRIAALEGGVAALLLASGQ 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 78 SAILLVTTVFLKPGDLLVAPHDCYGGSYRLFD-SLAKRGCyRVLFV-DQNDEQALSAALAEKPKLVLVESPSNPLLRVVD 155
Cdd:PRK07812 95 AAETFAILNLAGAGDHIVSSPRLYGGTYNLFHyTLPKLGI-EVSFVeDPDDLDAWRAAVRPNTKAFFAETISNPQIDVLD 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 156 IAKICGLAREAGAVSVVDNTFLSPALQNPLALGADLVLHSCTKYLNGHSDVVAGVVI----------------AKDPA-- 217
Cdd:PRK07812 174 IPGVAEVAHEAGVPLIVDNTIATPYLIRPLEHGADIVVHSATKYLGGHGTAIAGVIVdggtfdwtqgrfpgftTPDPSyh 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 218 --TVTELA----------WWANNIGVTGGAFDSYLLLRGLRTLSPRMEVAQRNALAIVDYLKSQPLVKKLYHPSLPENQG 285
Cdd:PRK07812 254 gvVFAELGppayalkarvQLLRDLGSAISPFNAFLIAQGLETLSLRIERHVANAQRVAEFLEARDEVASVNYAGLPSSPW 333
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 286 HEIAAR-QQKGFGAMLSFELDGDEQTLRRFLSGLSLFTLAESLGGVESLISHAATMTHAGMAPEARAAAGISETLLRIST 364
Cdd:PRK07812 334 YERAKRlAPKGTGAVLSFELAGGVEAGKAFVNALTLHSHVANIGDVRSLVIHPASTTHSQLTPEEQLATGVTPGLVRLAV 413
|
410
....*....|....*....
gi 503993435 365 GIEDGEDLIADLENGFRAA 383
Cdd:PRK07812 414 GIEGIDDILADLEAGFAAA 432
|
|
| PRK05968 |
PRK05968 |
hypothetical protein; Provisional |
16-383 |
7.96e-79 |
|
hypothetical protein; Provisional
Pssm-ID: 168320 [Multi-domain] Cd Length: 389 Bit Score: 247.69 E-value: 7.96e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 16 DDEQYGCVVPPIHLSSTYNFTGFNE------PRAHD--YSRRGNPTRDVVQRALAELEGGAGAVLTNTGMSAILLVTTVF 87
Cdd:PRK05968 19 EGNAFDAVVPPIFQTSLFTFDSYDEmedvyaGEKVRpiYSRGDNPTVRAFEEMLAKLEGAEDARGFASGMAAISSTVLSF 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 88 LKPGDLLVAPHDCYGGSYRLFDSLAKRGCYRVLFVDQNDEQALSAALAeKPKLVLVESPSNPLLRVVDIAKICGLAREAG 167
Cdd:PRK05968 99 VEPGDRIVAVRHVYPDAFRLFETILKRMGVEVDYVDGRDEEAVAKALP-GAKLLYLESPTSWVFELQDVAALAALAKRHG 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 168 AVSVVDNTFLSPALQNPLALGADLVLHSCTKYLNGHSDVVAGVVI--AKDPATVTELAWwanniGVTGGA---FDSYLLL 242
Cdd:PRK05968 178 VVTMIDNSWASPVFQRPITLGVDLVIHSASKYLGGHSDTVAGVVAgsKEHIARINAEAY-----PYLGAKlspFEAWLLL 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 243 RGLRTLSPRMEVAQRNALAIVDYLKSQPLVKKLYHPSLpenQGHEIAArqQKGFGAMLSFELDgDEQTLRRFLSGLSLFT 322
Cdd:PRK05968 253 RGLRTLPLRMKAHEASALEIARRLKAHPVVERVCHPAL---ANHPPAG--LSGTSGLFSFIFR-EGIDVRAFADALKLFR 326
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 503993435 323 LAESLGGVESLISHAATMTHAGMAPEARAAAGISETLLRISTGIEDGEDLIADLENGFRAA 383
Cdd:PRK05968 327 LGVSWGGHESLVVPAEVVLQQKAQPNSAARFGVSPRSVRLHVGLEGTEALWADLEQALAAA 387
|
|
| PRK07504 |
PRK07504 |
O-succinylhomoserine sulfhydrylase; Reviewed |
46-383 |
1.97e-77 |
|
O-succinylhomoserine sulfhydrylase; Reviewed
Pssm-ID: 168979 [Multi-domain] Cd Length: 398 Bit Score: 244.28 E-value: 1.97e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 46 YSRRGNPTRDVVQRALAELEGGAGAVLTNTGMSAILLVTTVFLKPGDLLVAPHDCYGGSYRLFDSLAKRGCYRVLFVDQN 125
Cdd:PRK07504 59 YSRYSNPTVDMFEKRMCALEGAEDARATASGMAAVTAAILCQVKAGDHVVAARALFGSCRYVVETLLPRYGIESTLVDGL 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 126 DEQALSAALAEKPKLVLVESPSNPLLRVVDIAKICGLAREAGAVSVVDNTFLSPALQNPLALGADLVLHSCTKYLNGHSD 205
Cdd:PRK07504 139 DLDNWEKAVRPNTKVFFLESPTNPTLEVIDIAAVAKIANQAGAKLVVDNVFATPLFQKPLELGAHIVVYSATKHIDGQGR 218
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 206 VVAGVVIAKDPATVTELAWWANNIGVTGGAFDSYLLLRGLRTLSPRMEVAQRNALAIVDYLKSQPLVKKLYHPSLPENQG 285
Cdd:PRK07504 219 CLGGVVLSDKAWIEEHLQDYFRHTGPSLSPFNAWTLLKGLETLPVRVRQQTESAAAIADFLAGHPKVARVIYPGRADHPQ 298
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 286 HEIAARQQKGFGAMLSFELDGDEQTLRRFLSGLSLFTLAESLGGVESLISHAATMTHAGMAPEARAAAGISETLLRISTG 365
Cdd:PRK07504 299 ADIIAKQMTGGSTLVAFELKGGKEAAFRFLNALKIVRISNNLGDAKSLITHPATTTHKNLSPEARAELGISEGFLRLSAG 378
|
330
....*....|....*...
gi 503993435 366 IEDGEDLIADLENGFRAA 383
Cdd:PRK07504 379 LEDTDDLIEDLAAALKKV 396
|
|
| PRK05939 |
PRK05939 |
cystathionine gamma-synthase family protein; |
19-383 |
9.28e-76 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 235650 [Multi-domain] Cd Length: 397 Bit Score: 239.97 E-value: 9.28e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 19 QYGCVVPPIHLSSTYnftGFNEPR-----------AHDYSRRGNPTRDVVQRALAELEGGAGAVLTNTGMSAILLVTTVF 87
Cdd:PRK05939 6 EHGAVHKPIHTSVTY---GYEDARdlidvfqgkkpGFTYARQGTPTTAALEAKITKMEGGVGTVCFATGMAAIAAVFLTL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 88 LKPGDLLVAPHDCYGGSYRLFDSLAKRGCyRVLFVDQNDEQALSAALAEKPKLVLVESPSNPLLRVVDIAKICGLAREAG 167
Cdd:PRK05939 83 LRAGDHLVSSQFLFGNTNSLFGTLRGLGV-EVTMVDATDVQNVAAAIRPNTRMVFVETIANPGTQVADLAGIGALCRERG 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 168 AVSVVDNTFLSPALQNPLALGADLVLHSCTKYLNGHSDVVAGVV-------------IAKDPATVTELAWWANNI----- 229
Cdd:PRK05939 162 LLYVVDNTMTSPWLFRPKDVGASLVINSLSKYIAGHGNALGGAVtdtglfdwsaypnIFPAYRKGDPQQWGLTQIrkkgl 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 230 ---GVTGGAFDSYLLLRGLRTLSPRMEVAQRNALAIVDYLKSQPLVKKLYHPSLPENQGHEIAARQQKGFGAMLSFELDG 306
Cdd:PRK05939 242 rdmGATLSSEAAHRIAIGAETLALRVDRSCSNALALAQFLEAHPKVARVYYPGLASHPQHARATELFRHYGGLLSFELAD 321
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 503993435 307 DEQTLrRFLSGLSLFTLAESLGGVESLISHAATMTHAGMAPEARAAAGISETLLRISTGIEDGEDLIADLENGFRAA 383
Cdd:PRK05939 322 GIDCF-DFLNRLKLVIKATHLGDTRTLVIPVAPTIYYEMGAERRASMGIADSLIRVSVGIEDEADLIADFEQALDAT 397
|
|
| PRK05994 |
PRK05994 |
O-acetylhomoserine aminocarboxypropyltransferase; Validated |
6-383 |
3.21e-72 |
|
O-acetylhomoserine aminocarboxypropyltransferase; Validated
Pssm-ID: 180344 [Multi-domain] Cd Length: 427 Bit Score: 231.91 E-value: 3.21e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 6 ATIAVRSGLNDDEQYGCVVPPIHLSSTYNFTGFNEPRA--------HDYSRRGNPTRDVVQRALAELEGGAGAVLTNTGM 77
Cdd:PRK05994 9 ATLAVHAGAQPDPTTGARATPIYQTTSFVFNDADHAASlfglqafgNIYTRITNPTNAVLEERVAALEGGTAALAVASGH 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 78 SAILLVTTVFLKPGDLLVAPHDCYGGSYRLFDSLAKRGCYRVLFVDQNDEQALSAALAEKPKLVLVESPSNPLLRVVDIA 157
Cdd:PRK05994 89 AAQFLVFHTLLQPGDEFIAARKLYGGSINQFGHAFKSFGWQVRWADADDPASFERAITPRTKAIFIESIANPGGTVTDIA 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 158 KICGLAREAGAVSVVDNTFLSPALQNPLALGADLVLHSCTKYLNGHSDVVAGVVI-------AKDP--ATVTE------- 221
Cdd:PRK05994 169 AIAEVAHRAGLPLIVDNTLASPYLIRPIEHGADIVVHSLTKFLGGHGNSMGGIIVdggtfdwSKSGkyPMLSEprpeyhg 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 222 --LAWWANNIGVTGGA--------------FDSYLLLRGLRTLSPRMEVAQRNALAIVDYLKSQPLVKKLYHPSLPENQG 285
Cdd:PRK05994 249 lvLHETFGNFAFAIAArvlglrdlgpaispFNAFLILTGIETLPLRMQRHSDNALAVAEWLKGHPKVSWVNYAGLPDDPY 328
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 286 HEIAAR-QQKGFGAMLSFELDGDEQTLRRFLSGLSLFTLAESLGGVESLISHAATMTHAGMAPEARAAAGISETLLRIST 364
Cdd:PRK05994 329 HALAQKySPKGAGAVFTFGLKGGYEAGVKLVSSLKLFSHLANIGDTRSLVIHPASTTHRQLTDEQKVAAGAGPDVVRLSI 408
|
410
....*....|....*....
gi 503993435 365 GIEDGEDLIADLENGFRAA 383
Cdd:PRK05994 409 GIEDVDDIIADLEQALAKA 427
|
|
| PRK08248 |
PRK08248 |
homocysteine synthase; |
7-383 |
1.24e-71 |
|
homocysteine synthase;
Pssm-ID: 236201 [Multi-domain] Cd Length: 431 Bit Score: 230.50 E-value: 1.24e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 7 TIAVRSGLNDDEQYGCVVPPIHLSSTYNFT---------GFNEPrAHDYSRRGNPTRDVVQRALAELEGGAGAVLTNTGM 77
Cdd:PRK08248 11 TLAIHAGQEIDPTTGSRAVPIYQTTSYGFRdsehaanlfSLKEF-GNIYTRIMNPTTDVFEKRIAALEGGIGALAVSSGQ 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 78 SAILLVTTVFLKPGDLLVAPHDCYGGSYRLFDSLAKRGCYRVLFVDQNDEQALSAALAEKPKLVLVESPSNPLLRVVDIA 157
Cdd:PRK08248 90 AAITYSILNIASAGDEIVSSSSLYGGTYNLFAHTLPKLGITVKFVDPSDPENFEAAITDKTKALFAETIGNPKGDVLDIE 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 158 KICGLAREAGAVSVVDNTFLSPALQNPLALGADLVLHSCTKYLNGHSDVVAGVVI-----------------AKDPA--- 217
Cdd:PRK08248 170 AVAAIAHEHGIPLIVDNTFASPYLLRPIEHGADIVVHSATKFIGGHGTSIGGVIVdsgkfdwkgsgkfpgltEPDPSyhg 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 218 -----TVTELAW-------WANNIGVTGGAFDSYLLLRGLRTLSPRMEVAQRNALAIVDYLKSQPLVKKLYHPSLPENQG 285
Cdd:PRK08248 250 lvytdAVGEAAYitkarvqLLRDLGAALSPFNSFLLLQGLETLHLRMERHSENALAVAKFLEEHEAVEWVSYPGLPSHPS 329
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 286 HEIAARQ-QKGFGAMLSFELDGDEQTLRRFLSGLSLFTLAESLGGVESLISHAATMTHAGMAPEARAAAGISETLLRIST 364
Cdd:PRK08248 330 YELAKKYlPKGQGAILTFGIKGGVEAGKKLIDSVKLFSHLANVGDSKSLIIHPASTTHQQLSEEEQLAAGVTPGLVRLSV 409
|
410
....*....|....*....
gi 503993435 365 GIEDGEDLIADLENGFRAA 383
Cdd:PRK08248 410 GTEAIDDILDDLRQAIRQS 428
|
|
| PRK06084 |
PRK06084 |
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase; |
4-383 |
2.39e-67 |
|
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase;
Pssm-ID: 180392 [Multi-domain] Cd Length: 425 Bit Score: 219.00 E-value: 2.39e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 4 KQATIAVRSGLNDDEQYGCVVPPIHLSSTYNFTGFN--------EPRAHDYSRRGNPTRDVVQRALAELEGGAGAVLTNT 75
Cdd:PRK06084 2 KLETLAIHAGYSPDPTTKAVAVPIYQTTSYAFDDTQhgadlfdlKVPGNIYTRIMNPTNDVLEQRVAALEGGVGALAVAS 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 76 GMSAILLVTTVFLKPGDLLVAPHDCYGGSYRLFDSLAKRGCYRVLFVDQNDEQALSAALAEKPKLVLVESPSNPLLRVVD 155
Cdd:PRK06084 82 GMAAITYAIQTIAEAGDNIVSVAKLYGGTYNLLAHTLPRIGIETRFAAHDDIAALEALIDERTKAVFCESIGNPAGNIID 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 156 IAKICGLAREAGAVSVVDNTFLSPALQNPLALGADLVLHSCTKYLNGHSDVVAGVVI------------------AKDPA 217
Cdd:PRK06084 162 IQALADAAHRHGVPLIVDNTVATPVLCRPFEHGADIVVHSLTKYIGGHGTSIGGIVVdsgkfpwaehkerfallnTPDPS 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 218 ----TVTE----LAWWAN-------NIGVTGGAFDSYLLLRGLRTLSPRMEVAQRNALAIVDYLKSQPLVKKLYHPSLPE 282
Cdd:PRK06084 242 yhgvTYTEafgpAAFIGRcrvvplrNMGAALSPFNAFLILQGLETLALRMERHTENALKVARYLQQHPQVAWVKYAGLPD 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 283 NQGHEIAARQQKGF-GAMLSFELDGDEQTLRRFLSGLSLFTLAESLGGVESLISHAATMTHAGMAPEARAAAGISETLLR 361
Cdd:PRK06084 322 HPEHELARRYMGGKpASILSFGIKGGQAAGARFIDALKLVVRLVNIGDAKSLACHPASTTHRQLNDEELEKAGVSRDMVR 401
|
410 420
....*....|....*....|..
gi 503993435 362 ISTGIEDGEDLIADLENGFRAA 383
Cdd:PRK06084 402 LSIGIEHIDDIIADLAQALDAS 423
|
|
| cysta_beta_ly_B |
TIGR01324 |
cystathionine beta-lyase, bacterial; This model represents cystathionine beta-lyase (alternate ... |
7-383 |
1.71e-66 |
|
cystathionine beta-lyase, bacterial; This model represents cystathionine beta-lyase (alternate name: beta-cystathionase), one of several pyridoxal-dependent enzymes of cysteine, methionine, and homocysteine metabolism. This enzyme is involved in the biosynthesis of Met from Cys. [Amino acid biosynthesis, Aspartate family]
Pssm-ID: 130391 [Multi-domain] Cd Length: 377 Bit Score: 215.51 E-value: 1.71e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 7 TIAVRSGLNDDEQYGCVVPPIHLSSTYNFTGFNEPRAHD----YSRRGNPTRDVVQRALAELEGGAGAVLTNTGMSAILL 82
Cdd:TIGR01324 1 TRLIHSGRQPRFSQGSVNPPLQRASTVLFDSHAAQRRAKgeltYGRRGTLTHFALQDAMCELEGGAGCYLYPSGLAAVTN 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 83 VTTVFLKPGDLLVAPHDCYGGSYRLFDSLAKRGCYRVLFVDQNDEQALSAALAEKPKLVLVESPSNPLLRVVDIAKICGL 162
Cdd:TIGR01324 81 SILAFVKAGDHVLMVDSAYEPTRYFCDIVLKRMGVDITYYDPLIGEDIATLIQPNTKVLFLEAPSSITFEIQDIPAIAKA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 163 AREAGAVSVVDNTFLSPALQNPLALGADLVLHSCTKYLNGHSDVVAGVVIAKDpATVTELAWWANNIGVTGGAFDSYLLL 242
Cdd:TIGR01324 161 ARNPGIVIMIDNTWAAGLLFKPLEHGVDISIQAGTKYLVGHSDIMIGTVVANA-RTWDQLREHSYLMGQMVDADDAYTTL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 243 RGLRTLSPRMEVAQRNALAIVDYLKSQPLVKKLYHPSLPENQGHEIAARQQKGFGAMLSFELDGDEQ-TLRRFLSGLSLF 321
Cdd:TIGR01324 240 RGLRTLGVRLKQHQESSLAIAKWLSEQPEVARVLHPALPSCPGHEFWKRDFSGSSGLFSFVLQRLTQkQVHAFLDHLQLF 319
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 503993435 322 TLAESLGGVESLishaATMTHAGMAPEARAAAGISETLLRISTGIEDGEDLIADLENGFRAA 383
Cdd:TIGR01324 320 GLGYSWGGYESL----ALCNQPELGHRPNIKRNLEGPLIRVHIGLENVDDLKADLKAGFEAI 377
|
|
| PRK05967 |
PRK05967 |
cystathionine beta-lyase; Provisional |
3-384 |
2.67e-66 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 235657 [Multi-domain] Cd Length: 395 Bit Score: 215.44 E-value: 2.67e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 3 RKQATIAVR---SGLNDDEQYGCVVPPIHLSSTYNF----TGFNEPRAHDYSRRGNPTRDVVQRALAELEGGAGAVLTNT 75
Cdd:PRK05967 8 TEKAGINTRlahDGNDPGDYHGFVNPPVVHASTVLFpdaeTMATRGQKYTYGTRGTPTTDALCKAIDALEGSAGTILVPS 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 76 GMSAILLVTTVFLKPGDLLVAPHDCYGGSYRLFDSLAKRGCYRVLFVDQNDEQALSAALAEKPKLVLVESPSNPLLRVVD 155
Cdd:PRK05967 88 GLAAVTVPFLGFLSPGDHALIVDSVYYPTRHFCDTMLKRLGVEVEYYDPEIGAGIAKLMRPNTKVVHTEAPGSNTFEMQD 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 156 IAKICGLAREAGAVSVVDNTFLSPALQNPLALGADLVLHSCTKYLNGHSDVVAGVVIAKdpATVTELAWWAN-NIGVTGG 234
Cdd:PRK05967 168 IPAIAEAAHRHGAIVMMDNTWATPLYFRPLDFGVDISIHAATKYPSGHSDILLGTVSAN--EKCWPQLLEAHgTLGLCAG 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 235 AFDSYLLLRGLRTLSPRMEVAQRNALAIVDYLKSQPLVKKLYHPSLPENQGHEIAARQQKGFGAMLSFELDGDEQTLRR- 313
Cdd:PRK05967 246 PDDTYQILRGLRTMGIRLEHHRKSALEIARWLEGRPDVARVLHPALPSFPGHEIWKRDFSGASGIFSFVLAAGPEKGKAk 325
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 503993435 314 ---FLSGLSLFTLAESLGGVESLishaatMTHAGMAPEARAAAGISETLLRISTGIEDGEDLIADLENGFRAAN 384
Cdd:PRK05967 326 ahaFLDALEIFGLGYSWGGYESL------ALHVKLGDRTVAKAPYAGPVIRLQIGLEDVPDLKADLERGFAAAS 393
|
|
| PRK07050 |
PRK07050 |
cystathionine beta-lyase; Provisional |
1-384 |
7.02e-60 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 180810 [Multi-domain] Cd Length: 394 Bit Score: 198.79 E-value: 7.02e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 1 MTRKQATIAVRSGLNDDEQYGCVVPPIHLSSTYNFTGFNEPRAHD--------YSRRGNPTRDVVQRALAELEGGAGAVL 72
Cdd:PRK07050 6 PKRALQTRIVQPDDQIPPGFRSFVTPVARASTVVFPDLATMRALDwrqdvqwrYGLHATPTSLALAQRLAEIEGGRHALL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 73 TNTGMSAILLVTTVFLKPGDLLVAPHDCYGGSYRLFDSLAKRGCYRVLFVDQNDEQALSAALAEKPKLVLVESPSNPLLR 152
Cdd:PRK07050 86 QPSGLAAISLVYFGLVKAGDDVLIPDNAYGPNRDHGEWLARDFGITVRFYDPLIGAGIADLIQPNTRLIWLEAPGSVTME 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 153 VVDIAKICGLAREAGAVSVVDNTFLSPALQNPLALGADLVLHSCTKYLNGHSDVVAGVVIAKDPATVTELAWWANNIGVT 232
Cdd:PRK07050 166 VPDVPAITAAARARGVVTAIDNTYSAGLAFKPFEHGVDISVQALTKYQSGGSDVLMGATITADAELHAKLKLARMRLGIG 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 233 GGAFDSYLLLRGLRTLSPRMEVAQRNALAIVDYLKSQPLVKKLYHPSLPENQGHEIAARQQKGFGAMLSFELDG--DEQT 310
Cdd:PRK07050 246 VSADDCSLVLRGLPSLQVRLAAHDRSALEVAEWLKARPEIATVLHPALPDCPGHAFWMRDFTGAGGLFSVVFDErySPAQ 325
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 503993435 311 LRRFLSGLSLFTLAESLGGVESLishAATMTHAGMAPEARAAAGiseTLLRISTGIEDGEDLIADLENGFRAAN 384
Cdd:PRK07050 326 VDAFVEALELFAIGWSWGGACSL---AMPYDVASMRTAKWPHRG---TLVRLYIGLEDEADLIADLEQALEAAL 393
|
|
| PRK09028 |
PRK09028 |
cystathionine beta-lyase; Provisional |
1-385 |
4.03e-59 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 181615 [Multi-domain] Cd Length: 394 Bit Score: 196.88 E-value: 4.03e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 1 MTRKQATIAVRSGLNDDEQYGCVVPPIHLSSTYNFTGFNEPR---------AHDYSRRGNPTRDVVQRALAELEGGAGAV 71
Cdd:PRK09028 1 MSEKKATKIVSAGRDKKWTKGVINPPVFRASTVVFDTVAEMRhaaknrangEMFYGRRGTPTHFAFQAAIVELEGGAGTA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 72 LTNTGMSAILLVTTVFLKPGDLLVAPHDCYGGSYRLFDSLAKRGCYRVLFVDQNDEQALSAALAEKPKLVLVESPSNPLL 151
Cdd:PRK09028 81 LYPSGAAAISNALLSFLKAGDHLLMVDSCYEPTRDLCDKILKGFGIETTYYDPMIGEGIRELIRPNTKVLFLESPGSITM 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 152 RVVDIAKICGLAREAGAVSVVDNTFLSPALQNPLALGADLVLHSCTKYLNGHSDVVAGVviakdpATVTELAW-----WA 226
Cdd:PRK09028 161 EVQDVPTLSRIAHEHDIVVMLDNTWASPINSRPFEMGVDISIQAATKYIVGHSDVMLGT------ATANEKHWdqlreHS 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 227 NNIGVTGGAFDSYLLLRGLRTLSPRMEVAQRNALAIVDYLKSQPLVKKLYHPSLPENQGHEIAARQQKGFGAMLSFEL-D 305
Cdd:PRK09028 235 YLMGQCTSPDDVYLAMRGLRTLGVRLAQHEKNALKVANWLATRPEVDHVRHPAFETCPGHEFFKRDFSGSNGLFSFVLkQ 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 306 GDEQTLRRFLSGLSLFTLAESLGGVESLIshaatMTHAGMApEARAAA--GISETLLRISTGIEDGEDLIADLENGFRAA 383
Cdd:PRK09028 315 GDPKAVTALVEGMQHFKMGFSWGGFESLI-----LGVFGIN-KLRTATnwDFSKPLIRLHIGLEDVDDLIADLEAGFERY 388
|
..
gi 503993435 384 NE 385
Cdd:PRK09028 389 NA 390
|
|
| PRK05613 |
PRK05613 |
O-acetylhomoserine/O-acetylserine sulfhydrylase; |
6-382 |
1.32e-55 |
|
O-acetylhomoserine/O-acetylserine sulfhydrylase;
Pssm-ID: 168128 [Multi-domain] Cd Length: 437 Bit Score: 188.54 E-value: 1.32e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 6 ATIAVRSGLNDDEQYGCVVPPIHLSSTYNFTG-------FN-EPRAHDYSRRGNPTRDVVQRALAELEGGAGAVLTNTGM 77
Cdd:PRK05613 15 ETRSIHAGQSVDSDTSARNLPIYQTTSYVFDSaehakqrFAlEDLGPIYSRLTNPTVEALENRIASLEGGVHAVAFASGQ 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 78 SAILLVTTVFLKPGDLLVAPHDCYGGSYRLFDSLAKRGCYRVLFV-DQNDEQALSAALAEKPKLVLVESPSNPLLRVVDI 156
Cdd:PRK05613 95 AAETAAILNLAGAGDHIVTSPRLYGGTETLFLVTLNRLGIEVTFVeNPDDPESWQAAVQPNTKAFFGETFANPQADVLDI 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 157 AKICGLAREAGAVSVVDNTFLSPALQNPLALGADLVLHSCTKYLNGHSDVVAGVVI---------------------AKD 215
Cdd:PRK05613 175 PAVAEVAHRNQVPLIVDNTIATAALVRPLELGADVVVASLTKFYTGNGSGLGGVLIdggkfdwtverdgkpvfpyfvTPD 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 216 PA----TVTELAWWA----------NNIGVTGGAFDSYLLLRGLRTLSPRMEVAQRNALAIVDYLKSQPLVKKLYHPSLP 281
Cdd:PRK05613 255 PAyhglKYADLGAPAfglkaragllRDTGATLSPFNAWVTAQGLDTLSLRLERHNENAIKVAEFLNNHEKVAKVNFAGLK 334
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 282 ENQGHeiAARQQKGF---GAMLSFELDGDEQTLRRFLSGLSLFTLAESLGGVESLISHAATMTHAGMAPEARAAAGISET 358
Cdd:PRK05613 335 DSPWY--ATKEKLGLkytGSVLSFDIKGGKDEAWAFIDALKLHSNLANIGDVRSLVVHPATTTHSQSDEAGLARAGITQA 412
|
410 420
....*....|....*....|....
gi 503993435 359 LLRISTGIEDGEDLIADLENGFRA 382
Cdd:PRK05613 413 TVRLSVGIEDIDDIIADLEGGFAA 436
|
|
| PLN02242 |
PLN02242 |
methionine gamma-lyase |
46-366 |
9.27e-55 |
|
methionine gamma-lyase
Pssm-ID: 215134 Cd Length: 418 Bit Score: 186.12 E-value: 9.27e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 46 YSRRGNPTRDVVQRALAELEGGAGAVLTNTGMSAILLVTTVFLKPGDLLVAPHDCYGGSYRLFDSLAKRGC-YRVLFVDQ 124
Cdd:PLN02242 70 YSRHFNPTVLNLGRQMAALEGTEAAYCTASGMSAISSVLLQLCSSGGHVVASNTLYGGTHALLAHFLPRKCnITTTFVDI 149
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 125 NDEQALSAALAE-KPKLVLVESPSNPLLRVVDIAKICGLAREAGAVSVVDNTFlSPALQNPLALGADLVLHSCTKYLNGH 203
Cdd:PLN02242 150 TDLEAVKKAVVPgKTKVLYFESISNPTLTVADIPELARIAHEKGVTVVVDNTF-APMVLSPARLGADVVVHSISKFISGG 228
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 204 SDVVAGVVIAkdPAT-VTELAWWANN----IGVTGGAFDSYLLLRGLRTLSPRMEVAQRNALAIVDYLKSQPLvkKLYHP 278
Cdd:PLN02242 229 ADIIAGAVCG--PAElVNSMMDLHHGalmlLGPTMNPKVAFELSERLPHLSLRMKEHCRRAMEYAKRMKELGL--KVIYP 304
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 279 SLPENQGHEIAARQQK---GFGAMLSFELDGDE--QTLRRFLSGLSLFTL-AESLGGVESLISHAATMTHAGMAPEARAA 352
Cdd:PLN02242 305 GLEDHPQHALLKSMANkgyGFGGLLCLDMDTEEraNRLMRYLQNSTQFGFmAVSLGYYETLMSCSGSSTSSELDPEEKAA 384
|
330
....*....|....
gi 503993435 353 AGISETLLRISTGI 366
Cdd:PLN02242 385 AGISPGLVRMSVGY 398
|
|
| PRK08114 |
PRK08114 |
cystathionine beta-lyase; Provisional |
1-381 |
6.51e-51 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 181231 [Multi-domain] Cd Length: 395 Bit Score: 175.28 E-value: 6.51e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 1 MTRKQ-ATIAVRSGLNDDEQYGCVVPPIHLSSTYNFTGFNEP------RAHD---YSRRGNPTRDVVQRALAELEGGAGA 70
Cdd:PRK08114 1 MTDKKlDTQLVNAGRSKKYTQGSVNSVIQRASSLVFDSVEAKkhatrnRANGelfYGRRGTLTHFSLQEAMCELEGGAGC 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 71 VLTNTGMSAILLVTTVFLKPGDLLVAPHDCYGGSYRLFDSLAKRGCYRVLFVDQNDEQALSAALAEKPKLVLVESPSNPL 150
Cdd:PRK08114 81 ALYPCGAAAVANAILAFVEQGDHVLMTGTAYEPTQDFCSKILSKLGVTTTWFDPLIGADIAKLIQPNTKVVFLESPGSIT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 151 LRVVDIAKICGLAREAG--AVSVVDNTFLSPALQNPLALGADLVLHSCTKYLNGHSDVVAGVVIAkDPATVTELAWWANN 228
Cdd:PRK08114 161 MEVHDVPAIVAAVRSVNpdAVIMIDNTWAAGVLFKALDFGIDISIQAGTKYLVGHSDAMIGTAVA-NARCWEQLRENSYL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 229 IGVTGGAFDSYLLLRGLRTLSPRMEVAQRNALAIVDYLKSQPLVKKLYHPSLPENQGHEIAARQQKGFGAMLSFELDG-- 306
Cdd:PRK08114 240 MGQMVDADTAYMTSRGLRTLGVRLRQHEESSLKVAEWLAEHPEVARVNHPALPGCKGHEFWKRDFTGSSGLFSFVLKKkl 319
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 503993435 307 DEQTLRRFLSGLSLFTLAESLGGVESLISHAATMTHAGMAPEarAAAGISETLLRISTGIEDGEDLIADLENGFR 381
Cdd:PRK08114 320 TDEQLANYLDNFSLFSMAYSWGGFESLILANQPEEIAAIRPA--GEVDFTGTLIRLHIGLEDVDDLIADLAAGFA 392
|
|
| PRK06702 |
PRK06702 |
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase; |
24-377 |
2.66e-50 |
|
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase;
Pssm-ID: 102505 [Multi-domain] Cd Length: 432 Bit Score: 174.47 E-value: 2.66e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 24 VPPIHLSSTYNFTG-------FN-EPRAHDYSRRGNPTRDVVQRALAELEGGAGAVLTNTGMSAILLVTTVFLKPGDLLV 95
Cdd:PRK06702 25 VLPLYQSTTYKYDTsddlaalFNlEAEGYIYTRIGNPTLAAFEQKLAELEGGVGAVATASGQAAIMLAVLNICSSGDHLL 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 96 APHDCYGGSYRLFD-SLAKRGCYRVLFVDQNDEQALSAALAEKPKLVLVESPSNPLLRVVDIAKICGLAREAGAVSVVDN 174
Cdd:PRK06702 105 CSSTVYGGTFNLFGvSLRKLGIDVTFFNPNLTADEIVALANDKTKLVYAESLGNPAMNVLNFKEFSDAAKELEVPFIVDN 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 175 TFLSPALQNPLALGADLVLHSCTKYLNGHSDVVAGVVIAK--------------DPATVTELAWWANNIGVTG------- 233
Cdd:PRK06702 185 TLATPYLCQAFEHGANIIVHSTTKYIDGHASSLGGIVIDGgnfdwtngkypelvEPDPSYHGVSYVQNFGAAAyivkarv 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 234 ----------GAFDSYLLLRGLRTLSPRMEVAQRNALAIVDYLKSQPLVKKLYHPSLPENQGHEIAARQ-QKGFGAMLSF 302
Cdd:PRK06702 265 qllrdygncmSPFNAYISNIGLETLHLRMERHSENALAVAKWLADHERIEWVNYPGLDSNENYSLAQKYlKKGASGVLTF 344
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 503993435 303 ELDGDEQTLRRFLSGLSLFTLAESLGGVESLISHAATMTHAGMAPEARAAAGISETLLRISTGIEDGEDLIADLE 377
Cdd:PRK06702 345 GIKGGLEAAKEFIANVKLATLVTHVADARTCVIHPASTTHRQLSAEDQRLAGVTSDLIRLSVGIEDVSDIIADLE 419
|
|
| AAT_I |
cd01494 |
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP) ... |
58-214 |
2.49e-09 |
|
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. Structure and sequence analysis has revealed that the PLP dependent enzymes can be classified into four major groups of different evolutionary origin: aspartate aminotransferase superfamily (fold type I), tryptophan synthase beta superfamily (fold type II), alanine racemase superfamily (fold type III), and D-amino acid superfamily (fold type IV) and Glycogen phophorylase family (fold type V).
Pssm-ID: 99742 [Multi-domain] Cd Length: 170 Bit Score: 55.85 E-value: 2.49e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 58 QRALAELEGGA--GAVLTNTGMSAILLVTTVFLKPGDLLVAPHDCYGGSYRLFDSLAKrgcYRVLFVDQNDEQALSA--- 132
Cdd:cd01494 6 EEKLARLLQPGndKAVFVPSGTGANEAALLALLGPGDEVIVDANGHGSRYWVAAELAG---AKPVPVPVDDAGYGGLdva 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 133 -----ALAEKPKLVLVESPSNPLLRVVDIAKICGLAREAGAVSVVDNTFLSPALQNPLAL----GADLVLHSCTKYLNGh 203
Cdd:cd01494 83 ileelKAKPNVALIVITPNTTSGGVLVPLKEIRKIAKEYGILLLVDAASAGGASPAPGVLipegGADVVTFSLHKNLGG- 161
|
170
....*....|.
gi 503993435 204 sdVVAGVVIAK 214
Cdd:cd01494 162 --EGGGVVIVK 170
|
|
| Aminotran_1_2 |
pfam00155 |
Aminotransferase class I and II; |
60-223 |
1.22e-07 |
|
Aminotransferase class I and II;
Pssm-ID: 395103 [Multi-domain] Cd Length: 351 Bit Score: 53.08 E-value: 1.22e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 60 ALAELEGG--------AGAVLTNTGMSA-ILLVTTVFLKPGDLLVAPHDCYGGSYRLFdSLAKRGCYRVLFVD----QND 126
Cdd:pfam00155 47 ALAKFLGRspvlkldrEAAVVFGSGAGAnIEALIFLLANPGDAILVPAPTYASYIRIA-RLAGGEVVRYPLYDsndfHLD 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 127 EQALSAALAEKPKLVLVESPSNPLLRVVDIAKIC---GLAREAGAVSVVD----NTFLSPALQNPLALGAD-----LVLH 194
Cdd:pfam00155 126 FDALEAALKEKPKVVLHTSPHNPTGTVATLEELEkllDLAKEHNILLLVDeayaGFVFGSPDAVATRALLAegpnlLVVG 205
|
170 180 190
....*....|....*....|....*....|....*....
gi 503993435 195 SCTK----------YLNGHSDVVAGVVIAKDPATVTELA 223
Cdd:pfam00155 206 SFSKafglagwrvgYILGNAAVISQLRKLARPFYSSTHL 244
|
|
| AAT_like |
cd00609 |
Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent ... |
71-201 |
1.29e-07 |
|
Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. The major groups in this CD corresponds to Aspartate aminotransferase a, b and c, Tyrosine, Alanine, Aromatic-amino-acid, Glutamine phenylpyruvate, 1-Aminocyclopropane-1-carboxylate synthase, Histidinol-phosphate, gene products of malY and cobC, Valine-pyruvate aminotransferase and Rhizopine catabolism regulatory protein.
Pssm-ID: 99734 [Multi-domain] Cd Length: 350 Bit Score: 53.11 E-value: 1.29e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 71 VLTNTGMSAILLVTTVFLKPGDLLVAPHDCYGGSYRLFdslAKRGCyRVLFV-------DQNDEQALSAALAEKPKLVLV 143
Cdd:cd00609 63 VVTNGAQEALSLLLRALLNPGDEVLVPDPTYPGYEAAA---RLAGA-EVVPVpldeeggFLLDLELLEAAKTPKTKLLYL 138
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 503993435 144 ESPSNPLLRVVD---IAKICGLAREAGAVSVVDNT---FLSPALQNPLALGAD-----LVLHSCTKYLN 201
Cdd:cd00609 139 NNPNNPTGAVLSeeeLEELAELAKKHGILIISDEAyaeLVYDGEPPPALALLDayervIVLRSFSKTFG 207
|
|
| AspB |
COG0436 |
Aspartate/methionine/tyrosine aminotransferase [Amino acid transport and metabolism]; ... |
71-174 |
4.93e-05 |
|
Aspartate/methionine/tyrosine aminotransferase [Amino acid transport and metabolism]; Aspartate/methionine/tyrosine aminotransferase is part of the Pathway/BioSystem: Isoleucine, leucine, valine biosynthesis
Pssm-ID: 440205 [Multi-domain] Cd Length: 387 Bit Score: 45.12 E-value: 4.93e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 71 VLTNTGMSAILLVTTVFLKPGD--LLVAPH-DCY-------GGSYRLFDSLAKRGcYRVlfvdqnDEQALSAALAEKPKL 140
Cdd:COG0436 94 LVTNGAKEALALALLALLNPGDevLVPDPGyPSYraavrlaGGKPVPVPLDEENG-FLP------DPEALEAAITPRTKA 166
|
90 100 110
....*....|....*....|....*....|....*..
gi 503993435 141 VLVESPSNPLLRVV---DIAKICGLAREAGAVSVVDN 174
Cdd:COG0436 167 IVLNSPNNPTGAVYsreELEALAELAREHDLLVISDE 203
|
|
| CsdA |
COG0520 |
Selenocysteine lyase/Cysteine desulfurase [Amino acid transport and metabolism]; |
88-173 |
3.41e-04 |
|
Selenocysteine lyase/Cysteine desulfurase [Amino acid transport and metabolism];
Pssm-ID: 440286 [Multi-domain] Cd Length: 396 Bit Score: 42.43 E-value: 3.41e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 88 LKPGD-LLVAPHDcYGGSYRLFDSLAKRGCYRVLFVDQNDE-----QALSAALAEKPKLVLVESPSNPLLRVVDIAKICG 161
Cdd:COG0520 100 LKPGDeILITEME-HHSNIVPWQELAERTGAEVRVIPLDEDgeldlEALEALLTPRTKLVAVTHVSNVTGTVNPVKEIAA 178
|
90
....*....|..
gi 503993435 162 LAREAGAVSVVD 173
Cdd:COG0520 179 LAHAHGALVLVD 190
|
|
| SufS_like |
cd06453 |
Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP) ... |
126-173 |
3.73e-04 |
|
Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine; and selenocysteine lyase catalyzes the decomposition of L-selenocysteine.
Pssm-ID: 99746 [Multi-domain] Cd Length: 373 Bit Score: 42.07 E-value: 3.73e-04
10 20 30 40
....*....|....*....|....*....|....*....|....*...
gi 503993435 126 DEQALSAALAEKPKLVLVESPSNPLLRVVDIAKICGLAREAGAVSVVD 173
Cdd:cd06453 128 DLEALEKLLTERTKLVAVTHVSNVLGTINPVKEIGEIAHEAGVPVLVD 175
|
|
| PLN02855 |
PLN02855 |
Bifunctional selenocysteine lyase/cysteine desulfurase |
71-206 |
7.89e-04 |
|
Bifunctional selenocysteine lyase/cysteine desulfurase
Pssm-ID: 215460 [Multi-domain] Cd Length: 424 Bit Score: 41.27 E-value: 7.89e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 71 VLTNTGMSAILLVT----TVFLKPGD---LLVAPHDCYGGSYRLFdsLAKRGCyrVL-FVDQN-----DEQALSAALAEK 137
Cdd:PLN02855 98 VFTRNATEAINLVAytwgLANLKPGDeviLSVAEHHSNIVPWQLV--AQKTGA--VLkFVGLTpdevlDVEQLKELLSEK 173
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 503993435 138 PKLVLVESPSNPLLRVVDIAKICGLAREAGAVSVVDNTFLSPALQ-NPLALGADLVLHSCTK--------YLNGHSDV 206
Cdd:PLN02855 174 TKLVATHHVSNVLGSILPVEDIVHWAHAVGAKVLVDACQSVPHMPvDVQTLGADFLVASSHKmcgptgigFLWGKSDL 251
|
|
| PRK08960 |
PRK08960 |
pyridoxal phosphate-dependent aminotransferase; |
71-201 |
1.30e-03 |
|
pyridoxal phosphate-dependent aminotransferase;
Pssm-ID: 181595 Cd Length: 387 Bit Score: 40.42 E-value: 1.30e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 71 VLTNTGMSAILLVTTVFLKPGD--LLVAP-HDCYGGSYRLFDslakrGCYRVLFVDQNDEQALSAALAE---KPKLV--L 142
Cdd:PRK08960 96 LVTPGGSGALLLASSLLVDPGKhwLLADPgYPCNRHFLRLVE-----GAAQLVPVGPDSRYQLTPALVErhwNADTVgaL 170
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 503993435 143 VESPSNP---LLRVVDIAKICGLAREAGAVSVVDNTF--LSPALQNPLALGAD---LVLHSCTKYLN 201
Cdd:PRK08960 171 VASPANPtgtLLSRDELAALSQALRARGGHLVVDEIYhgLTYGVDAASVLEVDddaFVLNSFSKYFG 237
|
|
| PRK05764 |
PRK05764 |
aspartate aminotransferase; Provisional |
71-149 |
1.64e-03 |
|
aspartate aminotransferase; Provisional
Pssm-ID: 235596 Cd Length: 393 Bit Score: 40.11 E-value: 1.64e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 71 VLTNTGMS-AILLVTTVFLKPGD--LLVAPhdcYGGSYRLFDSLAkrGCyRVLFVDQNDEQ-------ALSAALAEKPKL 140
Cdd:PRK05764 94 VIVTTGAKqALYNAFMALLDPGDevIIPAP---YWVSYPEMVKLA--GG-VPVFVPTGEENgfkltveQLEAAITPKTKA 167
|
....*....
gi 503993435 141 VLVESPSNP 149
Cdd:PRK05764 168 LILNSPSNP 176
|
|
| PRK07337 |
PRK07337 |
pyridoxal phosphate-dependent aminotransferase; |
71-201 |
4.03e-03 |
|
pyridoxal phosphate-dependent aminotransferase;
Pssm-ID: 180937 Cd Length: 388 Bit Score: 38.89 E-value: 4.03e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 71 VLTNTGMSAILLVTTVFLKPGDLLVAPHDCY----------GGSYRLFDS-LAKRgcyrvlFvdQNDEQALSAALAEKPK 139
Cdd:PRK07337 94 VVTAGASAALLLACLALVERGDEVLMPDPSYpcnrhfvaaaEGRPVLVPSgPAER------F--QLTAADVEAAWGERTR 165
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503993435 140 LVLVESPSNPL---LRVVDIAKICGLAREAGAVSVVDNTFLS----PALQNPLALGADLV-LHSCTKYLN 201
Cdd:PRK07337 166 GVLLASPSNPTgtsIAPDELRRIVEAVRARGGFTIVDEIYQGlsydAAPVSALSLGDDVItINSFSKYFN 235
|
|
| Aminotran_5 |
pfam00266 |
Aminotransferase class-V; This domain is found in amino transferases, and other enzymes ... |
111-173 |
5.73e-03 |
|
Aminotransferase class-V; This domain is found in amino transferases, and other enzymes including cysteine desulphurase EC:4.4.1.-.
Pssm-ID: 425567 [Multi-domain] Cd Length: 368 Bit Score: 38.38 E-value: 5.73e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 503993435 111 LAKRGCYRVLFVDQN-----DEQALSAALAEKPKLVLVESPSNPLLRVVDIAKICGLAREAGAVSVVD 173
Cdd:pfam00266 108 LAKRTGARVRVLPLDedgllDLDELEKLITPKTKLVAITHVSNVTGTIQPVPEIGKLAHQYGALVLVD 175
|
|
| |
