|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
26-436 |
2.55e-125 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 367.68 E-value: 2.55e-125
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 26 VFLGFCVIALDGFDIAIMGFIAPTLKQEWGVSNHQLGFVISAALIGLALGAIFSGPLADWLGRKKIIINSVFFFGFWTIA 105
Cdd:cd17365 1 LALCFLIIVLDGFDLAVMGFVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 106 TALSQNIEQMMVFRFLTGLGLGAAMPNIGTLVSEYAPERQRSFLITIIFCGFTFGAAAGGFSASWLIPQFGWHSLMLLGG 185
Cdd:cd17365 81 TAFAQSVLQLALLRFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 186 ILPLLFAPVLiwllpesvrflvvkrapaerirrimqrlypgqipdeaefslpaqpvqanamrivlsrqyrFGSMMLWLVY 265
Cdd:cd17365 161 VPPLILLPLL------------------------------------------------------------RGTLLLWVTF 180
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 266 FMGLFLVYLLGSWLPTLVKEVGLTVGQAAVMTAMYQAGGTLGSLFAGWLMDRINPHRALGLIYAVGGLFTMAMGYAAASF 345
Cdd:cd17365 181 FMGLLLVYLLNSWLPKLMVEAGYSLSQALTITLLLNIGGVIGSLLLGWLADRFGPKRVLALFFALGAVSLALLGVSPASL 260
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 346 ALICLLAFISGACLNGANTGMNALSARYYPTEARATGSSWMHGVGRMGAILSAFAGAEMLALNISFESVFLILGIPAAIT 425
Cdd:cd17365 261 VLLYVLVFLAGACVNGAQVGLYALAARFYPTEVRATGVGWALGVGRLGAILGPLLGGLLLAAGLGPESVFLALAIPAALG 340
|
410
....*....|.
gi 503994177 426 VAGLAAKGIFA 436
Cdd:cd17365 341 ALAVLLLRLRR 351
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
8-405 |
5.36e-114 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 340.49 E-value: 5.36e-114
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 8 DVRELINANPLSRFQKLVVFLGFCVIALDGFDIAIMGFIAPTLKQEWGVSNHQLGFVISAALIGLALGAIFSGPLADWLG 87
Cdd:TIGR00895 1 DVQNNIRKQPLSRYQWRAIILSFLIMLMDGYDLAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 88 RKKIIINSVFFFGFWTIATALSQNIEQMMVFRFLTGLGLGAAMPNIGTLVSEYAPERQRSFLITIIFCGFTFGAAAGGFS 167
Cdd:TIGR00895 81 RRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 168 ASWLIPQFGWHSLMLLGGILPLLFAPVLIWLLPESVRFLVVKRapAERIRRIMQRLYPgQIPDEAEFSLPAQPVQANAMR 247
Cdd:TIGR00895 161 AGWLIPVFGWRSLFYVGGIAPLLLLLLLMRFLPESIDFLVSKR--PETVRRIVNAIAP-QMQAEAQSALPEQKSTQGTKR 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 248 IV----LSRQYRFGSMMLWLVYFMGLFLVYLLGSWLPTLVKEVGLTVGQAAVMTAMYQAGGTLGSLFAGWLMDRINPhRA 323
Cdd:TIGR00895 238 SVfkalFQGKTARITVLLWLLYFMLLVGVYFLTNWLPKLMVELGFSLSLAATGGALFNFGGVIGSIIFGWLADRLGP-RV 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 324 LGLIYAVGGLFTMAMGYAAASFALICLLAFISGACLNGANTGMNALSARYYPTEARATGSSWMHGVGRMGAILSAFAGAE 403
Cdd:TIGR00895 317 TALLLLLGAVFAVLVGSTLFSPTLLLLLGAIAGFFVNGGQSGLYALMALFYPTAIRATGVGWAIGIGRLGAIIGPILAGY 396
|
..
gi 503994177 404 ML 405
Cdd:TIGR00895 397 LL 398
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
23-431 |
8.99e-75 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 239.86 E-value: 8.99e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 23 KLVVFLGFCVIALDGFDIAIMGFIAPTLKQEWGVSNHQLGFVISAALIGLALGAIFSGPLADWLGRKKIIINSVFFFGFW 102
Cdd:PRK11551 14 ALTIGLCFLVALLEGLDLQSAGVAAPRMAQEFGLDVAQMGWAFSAGILGLLPGALLGGRLADRIGRKRILIVSVALFGLF 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 103 TIATALSQNIEQMMVFRFLTGLGLGAAMPNIGTLVSEYAPERQRSFLITIIFCGFTFGAAAGGFSASWLIPQFGWHSLML 182
Cdd:PRK11551 94 SLATAQAWDFPSLLVARLLTGVGLGGALPNLIALTSEAVGPRLRGTAVSLMYCGVPFGGALASVIGVLAAGDAAWRHIFY 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 183 LGGILPLLFAPVLIWLLPESVRFLVVKRAPAERirrimqrlypgqipdeaefslpaqpvqANAMRIVLSRQYRFGSMMLW 262
Cdd:PRK11551 174 VGGVGPLLLVPLLMRWLPESRAFAQAAGAGKQR---------------------------APVLRALFGEGRATATLLLW 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 263 LVYFMGLFLVYLLGSWLPTLVKEVGLTVGQAAVMTAMYQAGGTLGSLFAGWLMDRINPHRALGLIYAvGGLFTMAMGYAA 342
Cdd:PRK11551 227 ISYFFTLIVLYFLLNWLPSLLVGQGLSRSQAGLVQIAFNIGGALGSLLIGALMDRLRPRRVVLLIYA-GILASLAALAAA 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 343 ASFALICLLAFISGACLNGANTGMNALSARYYPTEARATGSSWMHGVGRMGAILSAFAGAEMLALNISfESVFLILGIPa 422
Cdd:PRK11551 306 PSFAGMLLAGFAAGLFVVGGQSVLYALAPLFYPTQVRGTGVGAAVAVGRLGSMAGPLLAGQLLALGRS-TVGVIGASIP- 383
|
....*....
gi 503994177 423 AITVAGLAA 431
Cdd:PRK11551 384 VILVAALAA 392
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
15-427 |
1.47e-47 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 167.35 E-value: 1.47e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 15 ANPLSRFQKLVVFLGFCVIALDGFDIAIMGFIAPTLKQEWGVSNHQLGFVISAALIGLALGAIFSGPLADWLGRKKIIIN 94
Cdd:COG2271 1 ARAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 95 SVFFFGFWTIATALSQNIEQMMVFRFLTGLGLGAAMPNIGTLVSEYAPERQRSFLITIIFCGFTFGAAAGGFSASWLIPQ 174
Cdd:COG2271 81 GLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 175 FGWHSLMLLGGILPLLFAPVLIWLlpesvrflvvkrapaerirrimqrlypgqipdeaefslpaqpvqanamrivlsrqy 254
Cdd:COG2271 161 FGWRAAFLILGLPGLLLALLRFWL-------------------------------------------------------- 184
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 255 rfgsmmLWLVYFMGLFLVYLLGSWLPTLVKEV-GLTVGQAAVMTAMYQAGGTLGSLFAGWLMDRINPHR-ALGLIYAVGG 332
Cdd:COG2271 185 ------LALAYFLVYFALYGFLTWLPTYLVEVrGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRkLVLAIGLLLA 258
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 333 LFTMAMGYAAASFALICLLAFISGACLNGANTGMNALSARYYPTEARATGSSWMHGVGRMGAILSAFAGAEMLALnISFE 412
Cdd:COG2271 259 ALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDA-TGYQ 337
|
410
....*....|....*
gi 503994177 413 SVFLILGIPAAITVA 427
Cdd:COG2271 338 AAFLLLAALALLAAL 352
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
26-430 |
1.31e-45 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 162.00 E-value: 1.31e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 26 VFLGFCVIALDGFDIAIMGFIAPTLKQE--WGVSNHQLGFVISAALIGLALGAIFSGPLADWLGRKKIIINSVFFFGFWT 103
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEfsLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLAT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 104 IATALSQNIEQMMVFRFLTGLGLGAAMPNIGTLVSEYAPERQRSFLITIIFCGFTFGAAAGGFSASWLIP----QFGWHS 179
Cdd:cd17316 81 LLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPllsgDWGWRI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 180 LMLLGGILPLLFAPVLIWLLpesvrflvvkrapaerirrimqrlypgqipdeaefslpaqpvqanamrivlsrqyrfgsm 259
Cdd:cd17316 161 LFLIGALPALLALLLRRRTL------------------------------------------------------------ 180
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 260 MLWLVYFMGLFLVYLLGSWLPTLVKEV-GLTVGQAAVMTAMYQAGGTLGSLFAGWLMDRINPHRALGLIYAVGGLFTMAM 338
Cdd:cd17316 181 LLILLWFFISFGYYGLTTFLPTYLQTVlGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPL 260
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 339 GYA-AASFALICLLAFISGACLNGANTGMNALSARYYPTEARATGSSWMHGVGRMGAILSAFAGAEMLALNISFESVFLI 417
Cdd:cd17316 261 FYLlSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALI 340
|
410
....*....|...
gi 503994177 418 LGIPAAITVAGLA 430
Cdd:cd17316 341 LALLAIVALIVAL 353
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
27-430 |
4.74e-42 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 153.23 E-value: 4.74e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 27 FLGFcviALDGFDIAIMGFIAPTLKQEWGVSNHQLGFVISAALIGLALGAIFSGPLADWLGRKKIIINSVFFFGFWTIAT 106
Cdd:cd17371 5 FLGW---ALDGFDLLLLGLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLC 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 107 ALSQNIEQMMVFRFLTGLGLGAAMPNIGTLVSEYAPERQRSFLITIIFCGFTFGAAAGGFSASWLIP----QFGWHSLML 182
Cdd:cd17371 82 GFAQNYWQLLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAALLFPllppEIAWRVLFL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 183 LgGILPLLFAPVLIWLLPESVRFLVVKRAPAERIRRIMQrlypgqipdeaefslpaqpvqanamRIVLSRQYRfGSMMLW 262
Cdd:cd17371 162 L-GALPALLVLFIRRFVKEPPQWQAARAARRHFADRPSL-------------------------RELFSPPLL-RTTLLA 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 263 LVYFMG-LFLVYLLGSWLPTLVKEV-GLTVGQAAVMTAMYQAGGTLGSLFAGWLMDRINPHRALGLIYAVGGLFTMAMGY 340
Cdd:cd17371 215 SLLATGaLGGYYGITTWLPSYLTGErGLSFEGSAGYLVVTILGGFLGYLAGGFLADRIGRRNNFALFALGSAISILLYFF 294
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 341 AAASFALICLLAFISGACLNGANTGMNALSARYYPTEARATGSSWMHGVGRMGAILSAFaGAEMLALNISFESVFLILGI 420
Cdd:cd17371 295 LPLSPTLILILGFPLGFFASGPFSGMGAYLTELFPTAVRATAQGFCYNVGRIIGALFPF-LVGFLATSGSLGTAIAVFAA 373
|
410
....*....|
gi 503994177 421 PAAITVAGLA 430
Cdd:cd17371 374 VYYIAGLVLA 383
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
22-429 |
3.93e-39 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 145.41 E-value: 3.93e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 22 QKLVVFLGFCVIALDGFDIAIMGFIAPTLKQEWGVSNHQLGFVISAALIGLALGAIFSGPLADWLGRKKIIINSVFFFGF 101
Cdd:COG2223 3 RWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGI 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 102 WTIATALSQNIEQMMVFRFLTGLGLGAAMPNIGTLVSEYAPERQRSFLITIIFCGFTFGAAAGGFSASWLIPQFGWHSLM 181
Cdd:COG2223 83 GLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAF 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 182 LLGGILPLLFAPVLIWLLpesvrflvvkrapaerirrimqrlypgqiPDEAEFSLPAQPVQANAMRIVLsRQYRFgsMML 261
Cdd:COG2223 163 LILGILLLVVAVLAWLFL-----------------------------RDPPAGAAAAAKASLRDQLEAL-RDPRF--WLL 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 262 WLVYFMGLFLVYLLGSWLPTLVKEV-GLTVGQAAVMTAMYQAGGTLGSLFAGWLMDRINPHRALGLIYAVGGLFTMAMGY 340
Cdd:COG2223 211 SLLYFGTFGSFIGFSSWLPPYLVDQfGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLAL 290
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 341 AAASFALICLLAFISGACLNGANTGMNALSARYYPTEARATGSSWMHGVGRMGAILSAFAGAEMLALNISFESVFLILGI 420
Cdd:COG2223 291 ALGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAAFLVFAV 370
|
....*....
gi 503994177 421 PAAITVAGL 429
Cdd:COG2223 371 LALVALVLT 379
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
16-397 |
2.36e-37 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 139.72 E-value: 2.36e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 16 NPLSRFQKLVVFLGFCVIALDGFDIAIMGFIAPTLKQEWGVSNHQLGFVISAALIGLALGAIFSGPLADWLGRKKIIINS 95
Cdd:COG2814 2 PATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 96 VFFFGFWTIATALSQNIEQMMVFRFLTGLGLGAAMPNIGTLVSEYAPERQRSFLITIIFCGFTFGAAAGGFSASWLIPQF 175
Cdd:COG2814 82 LLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLF 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 176 GWHSLMLLGGILPLLFAPVLIWLLPESVRflVVKRAPAERIRRIMQRLypgqipdeaefslpaqpvqanamrivlsrqyr 255
Cdd:COG2814 162 GWRWVFLVNAVLALLALLLLLRLLPESRP--AARARLRGSLRELLRRP-------------------------------- 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 256 fGSMMLWLVYFMGLFLVYLLGSWLPTLVKEV-GLTVGQAAVMTAMYQAGGTLGSLFAGWLMDRINPHRALGLIYAVGGLF 334
Cdd:COG2814 208 -RLLLLLLLAFLLGFGFFALFTYLPLYLQEVlGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALG 286
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 503994177 335 TMAMGYaAASFALICLLAFISGACLNGANTGMNALSARYYPTEARATGSSWMHGVGRMGAILS 397
Cdd:COG2814 287 LLLLAL-AGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPLA 348
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
24-429 |
5.44e-33 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 127.69 E-value: 5.44e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 24 LVVFLGFCVIALDGFDIAIMGFIAPTLKQEWGVSNHQLGFVISAALIGLALGAIFSGPLADWLGRKKIIINSVFFFGFWT 103
Cdd:cd17319 3 RIIPLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFT 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 104 IATALSQNIEQMMVFRFLTGLGLGAAMPNIGTLVSEYAPERQRSFLITIIFCGFTFGAAAGGFSASWLIPQFGWHSLMLL 183
Cdd:cd17319 83 ALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFII 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 184 GGILPLLFAPVLIWLLPesvRFLvvkrapaerirrimqrlypgqipdeaefslpaqpvqanamrivlsrqyrfgsmMLWL 263
Cdd:cd17319 163 EGLLGLLLAVLWWFYLR---QVW-----------------------------------------------------GLAL 186
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 264 VYFMGLFLVYLLGSWLPTLVKEV-GLTVGQAAVMTAMYQAGGTLGSLFAGWLMDRINPHRA---LGLIYAVGGLFTMAMG 339
Cdd:cd17319 187 GYFGINYALYGLLTWLPTYLKQArGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLRGARrlvIIIGLLLAAVGLLLAY 266
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 340 YAAASFALICLLAfISGACLNGANTGMNALSARYYPTEARATGSSWMHGVGRMGAILSAFAGAEMLALNISFESVFLILG 419
Cdd:cd17319 267 LTTSPVVAVILLS-LAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATGSYTAAFLFLA 345
|
410
....*....|
gi 503994177 420 IPAAITVAGL 429
Cdd:cd17319 346 AVALLAALLV 355
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
46-399 |
2.12e-29 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 120.12 E-value: 2.12e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 46 IAPTLKQEWG---VSNHQLGFVISAALIGLALGAIFSGPLADWLGRKKIIINSVFFFGFWTIATALSQNIEQMMVFRFLT 122
Cdd:TIGR00898 111 FSSTIVTEWDlvcEDAWKVDLTQSCFFVGVLLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLV 190
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 123 GLGLGAAMPNIGTLVSEYAPERQRSFLITIIFCGFTFGAAAGGFSAsWLIPQFGWhslMLLGGILPLLFAPVLIWLLPES 202
Cdd:TIGR00898 191 GMGIGGIWVQAVVLNTEFLPKKQRAIVGTLIQVFFSLGLVLLPLVA-YFIPDWRW---LQLAVSLPTFLFFLLSWFVPES 266
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 203 VRFLVVKRAPaERIRRIMQRL--YPGQIPDEAEFSLPAQ------PVQANAMRIVLSRQYRFGSMMLWLVYFMGLFLVYL 274
Cdd:TIGR00898 267 PRWLISQGRI-EEALKILQRIakINGKKLPAEVLSLSLEkdlsssKKQYSFLDLFRTPNLRKTTLCLMMLWFTTAFSYYG 345
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 275 LGSWLPTLvkevgltvGQAAVMTAMYQAGGTLGSLFAGWLMDRINPHR-ALGLIYAVGGLFTMAMGYAAAS-FALICLLA 352
Cdd:TIGR00898 346 LVLDLGNL--------GGNIYLDLFISGLVELPAKLITLLLIDRLGRRyTMAASLLLAGVALLLLLFVPVDlYFLRTALA 417
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 503994177 353 FISGACLNGANTGMNALSARYYPTEARATGSSWMHGVGRMGAILSAF 399
Cdd:TIGR00898 418 VLGKFGITSAFQMVYLYTAELYPTVVRNLGVGVCSTMARVGSIISPF 464
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
28-398 |
4.78e-28 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 113.67 E-value: 4.78e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 28 LGFCVIALDGFDIAIMGFIAPTLKQEWGVSNHQLGFVISAALIGLALGAIFSGPLADWLGRKKIIINSVFFFGFWTIATA 107
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 108 LSQNIEQMMVFRFLTGLGLGAAMPNIGTLVSEYAPERQRSFLITIIFCGFTFGAAAGGFSASWLIPQFGWHSLMLLGGIL 187
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 188 PLLFAPVLiwllpesvrFLVVKRAPAERIRRIMQRLYPGQIPDEAEFSLPAqpvqanamrivlsrqyrfgsMMLWLVYFM 267
Cdd:pfam07690 161 SLLAAVLL---------LLPRPPPESKRPKPAEEARLSLIVAWKALLRDPV--------------------LWLLLALLL 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 268 GLFLVYLLGSWLPTLVKEVGLTVGQAAVMTAMYQAGGTLGSLFAGWLMDRINPHRALGLIYAVGGLFTMAMGYAAA--SF 345
Cdd:pfam07690 212 FGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLtlSS 291
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 503994177 346 ALICLLAFISGACLNGANTGMNALSARYYPTEARATGSSWMHGVGRMGAILSA 398
Cdd:pfam07690 292 LWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
30-426 |
1.44e-26 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 110.21 E-value: 1.44e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 30 FCVIALDGFDIAIMGFIAPTLKQEWGVSNHQLGFVISAALIGLALGAIFSGPLADWLGRKKIIINSVFFFGFWTIATALS 109
Cdd:cd06174 2 LLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 110 QNIEQMMVFRFLTGLGLGAAMPNIGTLVSEYAPERQRSFLITIIFCGFTFGAAAGGFSASWLIPQ--FGWHSLMLLGGIL 187
Cdd:cd06174 82 PSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSlgFGWRAVFLIAAAL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 188 PLLFApVLIWLLPESVRFLVVKRAPAERIRRIMQRLypgqipdeaefslpaqpvqanaMRIVLSRQYRFGSMMLWLVYFM 267
Cdd:cd06174 162 ALLAA-ILLLLVVPDPPESARAKNEEASSKSVLKLL----------------------KRVLKNPGLWLLLLAIFLVNLA 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 268 GLFLVYLlgsWLPTLVKEVGLTVGQAAVMTAMYQAGGTLGSLFAGWLMDRINPHRALGLIYAVGGLFTMAMGYAAASFAL 347
Cdd:cd06174 219 YYSFSTL---LPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLL 295
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 503994177 348 ICLLAFISGACLNGANTGMNALSARYYPTEARATGSSWMHGVGRMGAILSAFAGAEMLALNISFESVFLILGIPAAITV 426
Cdd:cd06174 296 LLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAA 374
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
30-430 |
4.20e-25 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 106.12 E-value: 4.20e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 30 FCVIALDGFDIAIMGFIAPTLKQEWGVSNHQLGFVISAALIGLALGAIFSGPLADWLGRKKIIINSVFFFGFWTIATALS 109
Cdd:cd17325 2 SLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 110 QNIEQMMVFRFLTGLGLGAAMPNIGTLVSEYAPERQRSFLITIIFCGFTFGAAAGGFSASWLIPQFGWHSLMLLGGILPL 189
Cdd:cd17325 82 TSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALAL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 190 LFAPVLIWLLPESVRFLVVKRAPAERIRRIMQRLypgqipdeaefslpaqpvqANAMRIVLsrqyrfgsmmLWLVYFMGL 269
Cdd:cd17325 162 LALVLALLLLPEPRPPPNKRAVSAARLRSGLRLL-------------------LRDRRLLA----------LFLAIFVLA 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 270 FLVYLLGSWLPTLVKEV-GLTVGQAAVMTAMYQAGGTLGSLFAGWLMDRINPHRALGLIYAVGGLFTMAMGYaAASFALI 348
Cdd:cd17325 213 FAFGALEPFLPLYAAELgGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPL-ATSFWLL 291
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 349 CLLAFISGACLNGANTGMNALSARYYPTEARATGSSWMHGVGRMGAILSAFAGAeMLALNISFESVFLILGIPAAITVAG 428
Cdd:cd17325 292 LLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGG-FLYDAFGFATPFLAAAALLLLAAVL 370
|
..
gi 503994177 429 LA 430
Cdd:cd17325 371 FL 372
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
24-424 |
1.05e-24 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 104.94 E-value: 1.05e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 24 LVVFLGFCVIALDGFdiAIMGfIAPTLKQEWGVSNHQLGFVISAALIGLALGAIFSGPLADWLGRKKIIINSVFFFGFWT 103
Cdd:cd17324 2 LALALAAFAIGTTEY--VIQG-LLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGN 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 104 IATALSQNIEQMMVFRFLTGLGLGAAMPNIGTLVSEYAPERQRSFLITIIFCGFTFGAAAGGFSASWLIPQFGWHSLMLL 183
Cdd:cd17324 79 LLAALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 184 GGILPLLFAPVLIWLLPESVRFLVVKRAPAERIRRimqrlypgqipdeaefslpaqpvqanamriVLSRQYRFGSMMLWL 263
Cdd:cd17324 159 IAVLALLAALLLWRLLPSLPPKKPGSLGLLSSLLL------------------------------LLRNPRLRLAYLITF 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 264 VYFMGLFLVYllgSWL-PTLVKEVGLTVGQAAVMTAMYQAGGTLGSLFAGWLMDRInPHRALGLIYAVGGLFTMAMGYAA 342
Cdd:cd17324 209 LLFGGFFALY---TYLaPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRG-GRRALLIALLLLAAALLLLTLLG 284
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 343 ASFALICLLAFISGACLNGANTGMNALSARYYPtEARATGSSWMHGVGRMGAILSAFAGAEMLAlNISFESVFLILGIPA 422
Cdd:cd17324 285 PSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAP-EARGLASSLYLAAYNLGGALGAALGGLVLD-HGGWAGVGWVGAALL 362
|
..
gi 503994177 423 AI 424
Cdd:cd17324 363 LL 364
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
35-213 |
1.18e-24 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 104.96 E-value: 1.18e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 35 LDGFDIAIMGFIAPTLKQEWGVSNHQLGFVISAALIGLALGAIFSGPLADWLGRKKIIINSVFFFGFWTIATALSQNIEQ 114
Cdd:cd17359 12 LFGYDTGVINGALPFLQTDFNLTPFLEGLVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFTI 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 115 MMVFRFLTGLGLGAAMPNIGTLVSEYAPERQRSFLITI--------IFCGFTFGAAAGGFSASWLIPQFGWHsLMLLGGI 186
Cdd:cd17359 92 FIIARIIGGLAVGGASALVPMYIAEVAPAEIRGRLVSLnqlmivfgQLLAYIVNYLIANAGGADWLGAEGWR-WMLGLEA 170
|
170 180
....*....|....*....|....*..
gi 503994177 187 LPLLFAPVLIWLLPESVRFLVVKRAPA 213
Cdd:cd17359 171 IPAILFLLGMLFIPESPRWLVSKGKPI 197
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
19-306 |
1.61e-24 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 102.97 E-value: 1.61e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 19 SRFQKLVVFLGFCVIALDGFDIAIMGFIAPTLKQEWGVSNHQLGFVISAALIGLALGAIFSGPLADWLGRKKIIINSVFF 98
Cdd:COG0477 9 TRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLL 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 99 FGFWTIATALSQNIEQMMVFRFLTGLGLGAAMPNIGTLVSEYAPERQRSFLITIIFCGFTFGAAAGGFSASWLIPQFGWH 178
Cdd:COG0477 89 FGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWR 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 179 SLMLLgGILPLLFAPVLIWLLPESVRFLVVKRAPAERIRRIMQRLYPGQIPDEAEFSLPAQPVQANAMRIVLSRQYRFGS 258
Cdd:COG0477 169 WIFLI-NAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLL 247
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 503994177 259 MMLWLVYFMGLFLVYLLGSWLPTLVKEVGLTVGQAAVMTAMYQAGGTL 306
Cdd:COG0477 248 LALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLALLL 295
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
19-431 |
1.82e-24 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 104.57 E-value: 1.82e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 19 SRFQKLVVFLGFCVIALD-GFDIAIMGFIAPTLKQEWGVSNHQLGFVISAALIGLALGAIFSGPLADWLGRKKIIINSVF 97
Cdd:COG2807 12 RRAGRWLLLLAIVLVALNlRPAITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 98 FFGFWTIATALSQNIEQMMVFRFLTGLGLGAAMPNIGTLVSEYAPERqRSFLITIIFCGFTFGAAAGGFSASWLIPQFGW 177
Cdd:COG2807 92 LLAAGLLLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWFPDR-VGLMTGLYTAAMGLGAALAAGLTVPLAAALGW 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 178 HSLMLLGGILPLLFAPVLIWLLPESVRflvvkrapaerirrimqrlypgqipdeaefslPAQPVQANAMRIVLSRQYRFg 257
Cdd:COG2807 171 RGALAVWALLALLALLLWLPLLRRRPA--------------------------------AAAAAPAAASLRSLWRSPLA- 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 258 sMMLWLVYFMGLFLVYLLGSWLPTLVKEVGLTVGQAAVMTAMYQAGGTLGSLFAGWLMDRINPHRALGLIYAV---GGLF 334
Cdd:COG2807 218 -WLLTLFFGLQSLLYYAVVAWLPPILRDAGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLGLlglAGLL 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 335 TMAMGYAAASFALICLLAFISGACLngaNTGMNALSARYYPTEARATGSSWMHGVGRMGAILSAFAGAEMLALNISFESV 414
Cdd:COG2807 297 GLLLAPGSLPWLWAVLLGLGQGGLF---PLALTLIGLRARTPAEAAALSGMAQSVGYLLAALGPLLVGALHDATGSWTAA 373
|
410
....*....|....*...
gi 503994177 415 FLILGIPAAI-TVAGLAA 431
Cdd:COG2807 374 LLLLAALAVLmLVAGLLA 391
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
37-384 |
5.69e-21 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 95.03 E-value: 5.69e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 37 GFDIAIMGFIAPTLKQ--EWGVSNH---------QLGFVISAALIGLALGAIFSGPLADWLGRKKIIINSVFFF---GFW 102
Cdd:pfam00083 13 GYDTGVIGAFLTLIDFfkNFGLSKSvsslaalsvLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFvigAVL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 103 TIATALSQNIEQMMVFRFLTGLGLGAAMPNIGTLVSEYAPERQRSFLITI--------IFCGFTFGAAAGGFSASWlipq 174
Cdd:pfam00083 93 QGAAKGKWSVYQLIVGRVLVGIGVGGASVLAPMYISEIAPKKLRGALGSLyqlaitfgILLAYIFGLGLNKTSNSD---- 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 175 fGWHSLMLLGGILPLLFApVLIWLLPESVRFLVVKRApAERIRRIMQRLYPGQIPDEA--------EFSLPAQPVQANAM 246
Cdd:pfam00083 169 -GWRIPLGLQLVPALLLI-IGLLFLPESPRWLVEKGR-LEEAREVLAKLRGVPDVDREldeikdslEAGQEAEKASWKEL 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 247 RIVLSRQYRF--GSMMLWLVYFMGLFLVYLLGswlPTLVKEVGLTvgQAAVMTAMYQAGGTLGSLFAGWLMDRINpHRAL 324
Cdd:pfam00083 246 FSTKTRRQRLliGVMLQIFQQLTGINAIFYYS---TTIFENLGLS--DSFLVTIIVGVVNFVFTFIAIFLVDRFG-RRPL 319
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 325 GLIYAVGGLFTMAM----------GYAAASFALICLLAFISGACLNGANTGMNALSARYYPTEARATGSS 384
Cdd:pfam00083 320 LLLGAAGMAICFVIlgivallgvsKSDWAGIVAIVFIALFIAFFAMGWGPVPWVIVSELFPLSVRSKAMA 389
|
|
| MFS_SVOP |
cd17441 |
Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic ... |
26-424 |
1.74e-20 |
|
Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein (SVOP) is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. This SVOP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340999 [Multi-domain] Cd Length: 372 Bit Score: 92.57 E-value: 1.74e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 26 VFLGFCVIAlDGFDIAIMGFIAPTLKQEWGVSNHQLGFVISAALIGLALGAIFSGPLADWLGRKKIIINSVFFFGFWTIA 105
Cdd:cd17441 2 ILTGLAWMA-DAMEMMILSILAPQLHCEWRLPSWQVALLTSVVFIGMMLSSSLWGNISDQYGRKTGLKISVLWTLYYGIL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 106 TALSQNIEQMMVFRFLTGLGLGAAmPNIGTLVSEYAPERQRSFLITIIFCGFTFGAAAGGFSASWLIPQFGWHSLMLLGG 185
Cdd:cd17441 81 SAFAPIYSWILVLRGLVGFGIGGV-PQSVTLYAEFLPMKSRAKCILLIEVFWALGTVFEVLLAVFVMPTLGWRWLLILSA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 186 ILPLLFAPVLIWlLPESVRFLVVkrAPAERIRRIMQRLYPGQIpdeaefSLPAQPVQANAMRIVLSRQYRFGSMMLWLVY 265
Cdd:cd17441 160 LPLLIFAVLCFW-LPESARYWTT--ILLWFIWFSNAFSYYGLV------LLTTELFQAGDVCSGSSGKKVEGKCSLECEY 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 266 FMGLFLVYLLGSwlpTLVKEVGLTVgqaavmtamyqaggTLgslfagWLMDRINPHRALGLIYAVGGLFTMAMGYAAASF 345
Cdd:cd17441 231 LTTSDYMDLLWT---TLSEFPGLLV--------------TL------WIIDRFGRKKTMALCFFVFSFCTLLLFSCVGRF 287
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 346 ALICLLaFISGACLNGANTGMNALSARYYPTEARATGSSWMHGVGRMGAILSAFAGAEMLALNISFE-SVFLILGIPAAI 424
Cdd:cd17441 288 SLTVLL-FIARAFISGGFQAAYVYTPEVYPTATRALGLGTCSGMARVGALITPFIAQVMLESSVYLTlSVYSGCCLLAAI 366
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
19-424 |
5.59e-20 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 91.45 E-value: 5.59e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 19 SRFQKLVVFLGFCVIALDGFDIAIMGFIAPTLKQEWGVSNHQLGFVISAALIGLALGAIFSGPLADWLGRKKIIINSVFF 98
Cdd:COG0738 3 KKNYRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 99 FGFWTIATALSQNIEQMMVFRFLTGLGLGAAMPNIGTLVSEYAPERQRSFLiTIIFCGFTFGAAAGGFSASWLIPQ---F 175
Cdd:COG0738 83 MALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPETAASRL-NLLHAFFSLGALLGPLLGGLLILLglsL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 176 GWHSLMLLGGILPLLFApVLIWLLPesvrflvvkrapaerirrimqrlypgqIPDEAEFSLPAQPVQANAMRIVLSRQYR 255
Cdd:COG0738 162 SWHLPYLILAVLLLLLA-LLFLRSK---------------------------LPEIEEEEEEAAGSAASLKSLLKNPRLL 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 256 FGSMMLwlvyFMGLFLVYLLGSWLPTLVKEV-GLTVGQAAVMTAMYQAGGTLGSLFAGWLMDRINPHRALgLIYAVGGLF 334
Cdd:COG0738 214 LGGLAI----FLYVGAEGAIGDWLPLYLKDVlGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLL-RLSALLAAV 288
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 335 TMAMGYAAASFALICLLAFISGACLNGANTGMNALSARYYPTEARATGSS--WMHGVGrmGAILSAFAGAemLALNISFE 412
Cdd:COG0738 289 GLLLALLAPGPWLALIGLALVGLGLSLMFPTIFSLALDGLGKRTAAAVSAvlIMGIVG--GAIGPPLIGF--LADAFGLR 364
|
410
....*....|..
gi 503994177 413 SVFLILGIPAAI 424
Cdd:COG0738 365 AAFLVPLVCYLL 376
|
|
| PRK12307 |
PRK12307 |
MFS transporter; |
18-438 |
1.88e-19 |
|
MFS transporter;
Pssm-ID: 237051 [Multi-domain] Cd Length: 426 Bit Score: 89.99 E-value: 1.88e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 18 LSRFQKLVVFLGFCVIALDGFDIAIMGFIAPTLKQEWGVSNHQLGFVISAALIGLALGAIFSGPLADWLGRKKIIINSVF 97
Cdd:PRK12307 12 ITRPQKNALFSAWLGYVFDGFDFMLIFYIMYLIKADLGLTDMEGAFLATAAFIGRPFGGALFGLLADKFGRKPLMMWSIV 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 98 FFGFWTIATALSQNIEQMMVFRFLTGLGLGAAMPNIGTLVSEYAPERQRSFLITIIFCGFtfgaAAGGFSASWLIPQF-- 175
Cdd:PRK12307 92 AYSVGTGLSGLASGVIMLTLSRFIVGMGMAGEYACASTYAVESWPKHLKSKASAFLVSGF----GIGNIIAAYFMPSFae 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 176 --GWHSLMLLgGILPLLfapVLIWllpesvrflVVKRAPAErirrimQRLYPGQIPDEAEFSLPAQPVQANAMRIVLSRQ 253
Cdd:PRK12307 168 ayGWRAAFFV-GLLPVL---LVIY---------IRARAPES------KEWEEAKLSGKGKHSQSAWSVFSLSMKGLFNRA 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 254 YRFGSMMLWLVYFMGLFLVYLLGSWLPTLVKEVGLTVGQAAVMTAMYQAGGTLGSLFAGWLMDRINPHRALGLiyavgGL 333
Cdd:PRK12307 229 QFPLTLCVFIVLFSIFGANWPIFGLLPTYLAGEGFDTGVVSNLMTAAAFGTVLGNIVWGLCADRIGLKKTFSI-----GL 303
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 334 FTmamgyaaaSFALICLLAFIS-------GACLNG---ANTGMNALSAR----YYPTEARATGSSWMHGVGRMGAILSAF 399
Cdd:PRK12307 304 LM--------SFLFIFPLFRIPqdnylllGACLFGlmaTNVGVGGLVPKflydYFPLEVRGLGTGLIYNLAATSGTFNSM 375
|
410 420 430
....*....|....*....|....*....|....*....
gi 503994177 400 AGaemlalniSFESVFLILGIPAAITVAGLAAKGIFAAG 438
Cdd:PRK12307 376 AA--------TWLGITMGLGAALTFIVAFWTATILLIIG 406
|
|
| SP |
TIGR00879 |
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of ... |
17-356 |
4.83e-19 |
|
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of the major facilitator superfamily (pfam00083) [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273317 [Multi-domain] Cd Length: 481 Bit Score: 89.32 E-value: 4.83e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 17 PLSRFQKLVVFLGFCV---IALDGFDIAIMGFIAPTLKQEW--------GVSNHQLGFVISAALIGLALGAIFSGPLADW 85
Cdd:TIGR00879 18 GLGSTYWKVALLSLIAaigGLMFGYDTGVIGGALALPAFEFkftsansdSYSSSLWGLVVSIFLVGGFIGALFAGWLSDR 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 86 LGRKK-IIINSVFFF--GFWTIATALSQNIEQMMVFRFLTGLGLGAAMPNIGTLVSEYAPERQRSFLITIIFCGFTFG-- 160
Cdd:TIGR00879 98 FGRKKsLLIIALLFVigAILMGLAAFALSVEMLIVGRVLLGIGVGIASALVPMYLSEIAPKALRGALTSLYQLAITFGil 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 161 -AAAGGFSASWLIPQFGWHSLMLLGGILPLLFApVLIWLLPESVRFLVVKRaPAERIRRIMQRLYPGQIPD-----EAEF 234
Cdd:TIGR00879 178 vAYGFGSGKVSLNNTLGWRIPLGLQLIPAGLLF-LGLFFLPESPRWLVGKG-RVEEARKSLARLRGTSGEDkelldELEL 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 235 SLPAQPVQANAMRIVLSRQYRFGSMMLWLVyFMGLFLVYL--LGSW------LPTLVKEVGLTVGQAAVMTAMYQAGGTL 306
Cdd:TIGR00879 256 IDIKRSIEKRSVQPSWGSLFSSTRRIRRRL-FLGVVLQWFqqFTGInaimyySPTIFENAGVSTDHAFLVSIIVGAVNFA 334
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 503994177 307 GSLFAGWLMDRINpHRALGLIYAVGGLFTMAMG------------YAAASFALICLLAFISG 356
Cdd:TIGR00879 335 FTFVAIFLVDRFG-RRPLLLIGAAGMAICLFVLgilgasfvtgssKSSGNVAIVFILLFIAF 395
|
|
| PRK03893 |
PRK03893 |
putative sialic acid transporter; Provisional |
34-402 |
1.01e-18 |
|
putative sialic acid transporter; Provisional
Pssm-ID: 179668 [Multi-domain] Cd Length: 496 Bit Score: 88.22 E-value: 1.01e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 34 ALDGFDIAIMGFIAPTLKQEWGVSNHQLGFVISAALIGLALGAIFSGPLADWLGRKKIIINSVFFFGFWTIATALSQNIE 113
Cdd:PRK03893 30 LLDGFDFVLITLVLTEVQGEFGLTTVQAASLISAAFISRWFGGLLLGAMGDRYGRRLAMVISIVLFSVGTLACGFAPGYW 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 114 QMMVFRFLTGLGLGAAMPNIGTLVSEYAPERQR----SFLITiifcGFTFGAAAGGFSASWLIPQFGWHSLMLLgGILPL 189
Cdd:PRK03893 110 TLFIARLVIGMGMAGEYGSSATYVIESWPKHLRnkasGFLIS----GFSIGAVVAAQVYSLVVPVWGWRALFFI-GILPI 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 190 LFAPVLIWLLPESVRFlVVKRAPAERIRRIMQRLYPGQ--IPD-----------EAEFSLPAQP--------VQANAMRI 248
Cdd:PRK03893 185 IFALWLRKNLPEAEDW-KEKHAGKAPVRTMVDILYRGEhrIINilltlaaaaalWFCFAGNLQNaaivavlgLLCAAIFI 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 249 VLSRQYRfGSMMLWLVYFMGLFLVYLLGSW-----LPTLVK-EVGLTVGQAAVMTAMYQAGGTLGSLFAGWLMDRINPHR 322
Cdd:PRK03893 264 SFMVQSS-GKRWPTGVMLMVVVLFAFLYSWpiqalLPTYLKtDLGYDPHTVANVLFFSGFGAAVGCCVGGFLGDWLGTRK 342
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 323 AlgliYAVGGLFTMAM-----GYAAASFALICLLAFISGACLNGANTGMNALSARYYPTEARATGSSWMHGVGRMGAILS 397
Cdd:PRK03893 343 A----YVCSLLISQLLiipvfAIGGANVWVLGLLLFFQQMLGQGISGLLPKLIGGYFDTEQRAAGLGFTYNVGALGGALA 418
|
....*
gi 503994177 398 AFAGA 402
Cdd:PRK03893 419 PILGA 423
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
26-200 |
1.64e-18 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 86.45 E-value: 1.64e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 26 VFLGFCVIALDGFDIAIMGFIAPTLKQEWGVSNHQLGFVISAALIGLALGAIFSGPLADWLGRKKIIINSVFFFGFWTIA 105
Cdd:cd17380 1 VILLFLATCICYADRVNMPIAIVPMAKEFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 106 T--ALSQNIEQMMVFRFLTGLGLGAAMPNIGTLVSEYAPERQRSFLITIIFCGFTFGAAAGGFSASWLIPQFGWHSLMLL 183
Cdd:cd17380 81 TplLAYSSLPLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYGWPSVFYF 160
|
170
....*....|....*..
gi 503994177 184 GGILPLLFAPVLIWLLP 200
Cdd:cd17380 161 FGLLGLLWALVWLIYLP 177
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
45-402 |
2.63e-18 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 86.28 E-value: 2.63e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 45 FIAPTLKQEWGVSNHQLGFVISAALIGLALGAIFSGPLADWLGRKKIIINSVFFFGFWTIATALSQNIEQMMVFRFLTGL 124
Cdd:TIGR00881 16 LAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWALNGI 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 125 GLGAAMPNIGTLVSEYAPERQRSFLITIIFCGFTFGAAAG-GFSASWLIPQFGWHSLMLLGGILPLLFAPVLIWLLPESV 203
Cdd:TIGR00881 96 FQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLpPLVLFGIAELYSWHWVFIVPGIIAIIVSLICFLLLRDSP 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 204 RflVVKRAPAERIRrimqrlypgqiPDEAEFSLPAQPVQANAMRIVLsrQYRFGSMMLWLVYFMGLFLV---YLLGSWLP 280
Cdd:TIGR00881 176 Q--SCGLPPAEEMP-----------NEEPDGDAEKKEEELTKKQIFL--QYVLLNKVLWYISLGYVFVYvvrTGILDWSP 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 281 T-LVKEVGLTVGQAAVMTAMYQAGGTLGSLFAGWLMDRI--NPHRALGLIYAVGGLFTMAMGY--AAASFALICLLAFIS 355
Cdd:TIGR00881 241 LyLTQEKGFSKEKASWAFTLYELGGLVGTLLAGWLSDKLfnGRRGPLAVFFMALIIVSLLVYWlnPAANPLMDLICLFAL 320
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 503994177 356 GACLNG--ANTGMNALSARyyPTEARATGSSWmhgVGRMGAILSAFAGA 402
Cdd:TIGR00881 321 GFLVYGpqMLIGVIASELA--PKKAAGTAAGF---VGFFAYLGGILAGL 364
|
|
| synapt_SV2 |
TIGR01299 |
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ... |
20-286 |
3.10e-18 |
|
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.
Pssm-ID: 130366 [Multi-domain] Cd Length: 742 Bit Score: 87.34 E-value: 3.10e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 20 RFQKLVVF-LGFCVIAlDGFDIAIMGFIAPTLKQEWGVSNHQLGFVISAALIGLALGAIFSGPLADWLGRKKIIINSVFF 98
Cdd:TIGR01299 163 RFQWALFFvLGLALMA-DGVEVFVVGFVLPSAEKDLCIPDSGKGMLGLIVYLGMMVGAFFWGGLADKLGRKQCLLICLSV 241
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 99 FGFWTIATALSQNIEQMMVFRFLTGLGLGAAMPNIGTLVSEYAPERQR----SFLITIIFCGFTFGAAaggfsASW-LIP 173
Cdd:TIGR01299 242 NGFFAFFSSFVQGYGFFLFCRLLSGFGIGGAIPIVFSYFAEFLAQEKRgehlSWLCMFWMIGGIYAAA-----MAWaIIP 316
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 174 QFGW----------HS--LMLLGGILPLLFAPVLIWLLPESVRFL-----------VVK---------RAPAERIRRIMQ 221
Cdd:TIGR01299 317 HYGWsfqmgsayqfHSwrVFVIVCAFPCVFAIGALTFMPESPRFFlengkhdeawmILKlihdtnmraKGHPEKVFSVNH 396
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 222 RLYPGQIPDEAEF----------------SLPAQpVQANAMRiVLSRQYRFGSMMLWLVYFMGLFLVYLLGSWLPTLVKE 285
Cdd:TIGR01299 397 IKTIHQEDELIEIesdtgtwyqrcfvralSEGGG-IWGNFLR-CFNPEVREITIKLMGVWFTLSFGYYGLSVWFPDMIKH 474
|
.
gi 503994177 286 V 286
Cdd:TIGR01299 475 L 475
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
40-431 |
7.00e-18 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 84.93 E-value: 7.00e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 40 IAIMGFIAPTLKQEWGVSNHQLGFVISAALIGLALGAIFSGPLADWLGRKKIIINSVFFFGFWTIATALSQNIEQMMVFR 119
Cdd:cd17474 15 VSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGR 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 120 FLTGLGLGAAMPNIGTLVSEYAPERQRSFLI----TIIFCGFTFGAAAGGF--SASWLIPQFgwhslmllggiLPLLFAP 193
Cdd:cd17474 95 ALQGIGAAGLGPLALTLIGDLFEGGERAKAMglyeAALGLGIAVGPLLGGLlaAISWRYPFF-----------LLAALIP 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 194 VLIWLLpesVRFLVVKRAPAERIRRIMQRlypgqipdeaefslpaqpvqanAMRIVLSRQYRFGSMMLWLVYFMGLFLVY 273
Cdd:cd17474 164 VAFLAI---LFLLPEPKEKAKSSSATKLR----------------------DLKKALRGRGLLTFLVSAFLYFFLYFAFL 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 274 llgSWLPTLVKEV-GLTVGQAAVMTAMYQAGGTLGSLFAGwlmdRINPHRALGLIYAVGGLFTMAMGYAAA----SFALI 348
Cdd:cd17474 219 ---TYLPFLLELLyGISPIIIGLLFAGWSVLLALGSLFVG----RLLKKRFGARRILVIGLLLYALSLLLLgfvpSLALL 291
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 349 CLLAFISGACLNGANTGMNALSARYYPTEARATGSSWMHGVGRMGAILSAFAGAeMLALNISFESVFLILGIPAAITVAG 428
Cdd:cd17474 292 LIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFG-LLLEIFGLSAPFLVGAAIALAAAVL 370
|
...
gi 503994177 429 LAA 431
Cdd:cd17474 371 LAL 373
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
44-361 |
2.41e-17 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 83.44 E-value: 2.41e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 44 GFIAPTLKQEWGVSNHQLGFVISAALIGLALGAIFSGPLADWLGRKKIIINSVFFFGFWTIATALSQNIEQMMVFRFLTG 123
Cdd:cd17475 16 PALAPFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLVG 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 124 LGLGAAMPNIGTLVSEYAPERQRSFLITIIFCGFTFGAAAGGFSASWLIPQFGWHSLMLLGGILPLLFAPVLIWLLPESV 203
Cdd:cd17475 96 AGYGSVQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLVSILAAVLFWLFYREPP 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 204 RFLVVKRApaerirrimqrlypgqipdeaefslpAQPVQANAMRIVLSRQyrfgsmmLWLVYFMGLFLVY----LLGSWL 279
Cdd:cd17475 176 AASAATES--------------------------ASTLLRSLKEVLRNRD-------VWLIAIAGALLVApqfaLLTFLL 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 280 PTLVKEVGLTVGQAAVMTAMYQAGGTLGSLFAGWLMDRINPHR-----ALGLIYAVGGLFTMAMGYAAASFALICLLAFI 354
Cdd:cd17475 223 LFLHDHLGLSVVAAGALLAVAQLGGALGRIGLGRVSDRVFGGRrrpvlVITAAIAAAALLVLSLLSPGTPLWLLVLLLIL 302
|
....*..
gi 503994177 355 SGACLNG 361
Cdd:cd17475 303 LGLFAIG 309
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
38-438 |
5.49e-17 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 82.24 E-value: 5.49e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 38 FDIAIMGFIAPTLKQEWGVSNHQLGFVISAALIGLALGAIFSGPLADWLGRKKIIINSVFFFGFWTIATALSQNIEQMMV 117
Cdd:cd17503 10 LDTTIVNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLII 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 118 FRFLTGLGLGAAMPNIGTLVSEYAPERQRSFLITIIFCGFTFGAAAGGFSASWLIPQFGWHSLMLLG---GILPLLFAPV 194
Cdd:cd17503 90 FRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINlpiGILALLLAPL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 195 LiwllpesvrflvvkrapaerirrimqrlypgqipdeaefslpaqpvqanAMRIVLSRQYRFGSMMLWLVYFMGLFLVYL 274
Cdd:cd17503 170 L-------------------------------------------------DLRLFKDRNFTLGLLLSFLLGLGLFGAMFL 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 275 LGSWLPTLvkeVGLTVGQAAVMTAMYQAGGTLGSLFAGWLMDRINPHRAL--GLIYAVGGLFTMAMGYAAASFALICLLA 352
Cdd:cd17503 201 LPLYLQNV---LGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLlaGLLLLALGTLLLAFLTPDTSLWLIILPL 277
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 353 FISGACLNGANTGMNALSARYYPTEARATGSSWMH---------GVGRMGAILSAFAGAEMLALNISFESVFLILGIPAA 423
Cdd:cd17503 278 FIRGLGMGLVFMPLNTLALNSLPPEQIGDATALFNtirqlggsiGTALLATLLTNRTQFHHSRLSELLAQQVQKQALIIA 357
|
410
....*....|....*
gi 503994177 424 ITVAGLAAKGIFAAG 438
Cdd:cd17503 358 FNDAFLVSAILLLVG 372
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
33-438 |
6.89e-17 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 81.84 E-value: 6.89e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 33 IALDGFDIAIMGFIAPTLKQEWGVSNHQLGFVISAALIGLALGAIFSGPLADWLGRKKIIINSVFFFGFWTIATALSQNI 112
Cdd:cd17321 5 VFLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 113 EQMMVFRFLTGLGLGAAMPNIGTLVSEYAPERQRSFLITIIFCGFTFGAAAGGFSASWLIPQFGWHSLMllggilpLLFA 192
Cdd:cd17321 85 AFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIF-------LINV 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 193 PVLIWLLpesvrflvvkrapaerirrimqrlypgqipdeaefslpaqpvqanamriVLSRQYRFGSMMLWLVYFMGLFLV 272
Cdd:cd17321 158 PIGLVAL-------------------------------------------------LLARTFSGAVLAAFLLGAALGGLL 188
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 273 YLLGSWLPTLvkeVGLTVGQAAVMTAMYQAGGTLGSLFAGWLMDRINPHR--ALGLIYAVGGLFTMAMGYAAASFALICL 350
Cdd:cd17321 189 FLLPLYLQGV---LGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLvlVAGLLLTAVGLLLLALLGADSSVWLLLP 265
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 351 LAFISGACLNGANTGMNALSARYYPTEARATGSSWMH---------GVGRMGAILSAFAGAEMLALNISFESVFLILGIP 421
Cdd:cd17321 266 GLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNtarqlggalGVALLGALLTAGLSANLGDSGVAALLSAAAAAFA 345
|
410
....*....|....*..
gi 503994177 422 AAITVAGLAAKGIFAAG 438
Cdd:cd17321 346 AGFHLAFLVAAALALLA 362
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
48-359 |
1.31e-16 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 81.08 E-value: 1.31e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 48 PTLKQEWGVSNHQLGFVISAALIGLALGAIFSGPLADWLGRKKIIINSVFFFGFWTIATALSQNIEQMMVFRFLTGLGLG 127
Cdd:cd17320 23 PAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLGAA 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 128 AAMPNIGTLVSEYAPERQRSFLITIIFCGFTFGAAAGGFSASWLIPQFGWHSLMLLGGILPLLFAPVLIWLLPESvrflv 207
Cdd:cd17320 103 AGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLALLGLLLLLLVLLFLPET----- 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 208 vkrapaerirrimqrlypgqiPDEAEFSLPAQPVQANAMRIVLSRQYRFGSMMLWLVyfMGLFLVYLLGSwlPTLVKEV- 286
Cdd:cd17320 178 ---------------------LPEEKRKPLLSSLLRAYKRVLKNRRFLGYALALGLS--FAGLFAYLAAA--PFIYIEQl 232
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 503994177 287 GLTVGQAAVMTAMYQAGGTLGSLFAGWLMDRINPHRAL--GLIYAVGGLFTMAMGYAAASFALICLLAFISGACL 359
Cdd:cd17320 233 GLSPAQFGLLFALNAIALILGSLLNGRLVRRFGPRRLLrlGLLLLLAAALVLLLAALLGGLSLWPLVAPLFLIFF 307
|
|
| MFS_SV2 |
cd17363 |
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic ... |
28-419 |
2.89e-16 |
|
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. The SV2 family belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340921 [Multi-domain] Cd Length: 474 Bit Score: 80.61 E-value: 2.89e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 28 LGFCVIAlDGFDIAIMGFIAPTLKQEWGVSNHQLGFVISAALIGLALGAIFSGPLADWLGRKKIIINSVFFFGFWTIATA 107
Cdd:cd17363 4 LGLALMA-DGVEVFVVGFVLPSAEKDMCLSNSNKGMLGLIVYLGMMVGAFVWGGLADKLGRKQCLLIALSVNGVFAFLSS 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 108 LSQNIEQMMVFRFLTGLGLGAAMPNIGTLVSEYAPERQRSFLITIIFCGFTFGAAAGGFSASWLIPQFGW---------- 177
Cdd:cd17363 83 FVQGYGFFLFCRLLSGIGIGGSIPIVFSYFAEFLAREKRGEHLSWLCMFWMIGGLYASAMAWAIIPHYGWgfsmgtayqf 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 178 HS--LMLLGGILPLLFAPVLIWLLPESVRFLvVKRAPAERIRRIMQRLYPGQIPDEAEfslPAQPVQANAMRivlsrqyR 255
Cdd:cd17363 163 HSwrVFVIVCALPSVASVVALTFMPESPRFL-LEVGKHDEAWMILKQVHDTNMRAKGH---PERVFTVSHIK-------R 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 256 FGSMMLWLVYFMGLFLVYLLGSWLPTLVKEVGL---------------------------TV------------------ 290
Cdd:cd17363 232 MNTLFLAIVWFTMSFSYYGLTVWFPDMIKYLQFedslfeecyfedvtstntffenctfinTVfyntdlfeykfidsrfln 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 291 ----------------GQAAVMTAMYQAGGTL----GSLFAGWLMDRINPHRALG---LIYAVGGLFTMAMGYAAASFAL 347
Cdd:cd17363 312 stfflkekcgchlnddEENAYLIYLVSFLGSLsvlpGNIVSALLMDKIGRLKMIGgsmLLSAVCCFFLFFGNSESAMIGL 391
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 503994177 348 ICLLAFISGACLNgantGMNALSARYYPTEARATGSSWMHGVGRMGAILSAFAGAEMLALN----ISFESVFLILG 419
Cdd:cd17363 392 QCLFCGVSIAAWN----ALDVVTVELYPTDKRATAFGFLNGLCKLAAILGNSIFGSFVGITkvipILLASAALVCG 463
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
43-207 |
5.50e-16 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 79.16 E-value: 5.50e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 43 MGFIAPTLKQ-----EWGVSNHQLGFVISAALIGLALGAIFSGPLADWLGRKK-IIINSVFFFGFwTIATALSQNIEQMM 116
Cdd:cd17315 13 LGVINGALLYiakdlGFGLSTSLQGLVVSSLLLGAAIGSLFGGPLADRFGRRKsLLIAAVLYVIG-ALLSALAPNVWVLI 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 117 VFRFLTGLGLGAAMPNIGTLVSEYAPERQRSFLITIIFCGFTFG---AAAGGFSASWLIPqfGWHSLMLLGGILPLLFAP 193
Cdd:cd17315 92 VGRFLLGLGVGLASVLVPLYISEIAPAKIRGALGTLNQLMITFGillAYLLGLALSLSPP--GWWRLMFALAAVPALLQL 169
|
170
....*....|....
gi 503994177 194 VLIWLLPESVRFLV 207
Cdd:cd17315 170 LLMFFLPESRALLV 183
|
|
| MFS_SVOP_like |
cd17372 |
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator ... |
36-422 |
7.15e-16 |
|
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator Superfamily; This subfamily is composed of synaptic vesicle 2 (SV2)-related protein (SVOP), SVOP-like protein (SVOPL), and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP and SVOPL share structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. The SVOP-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340930 [Multi-domain] Cd Length: 367 Bit Score: 78.73 E-value: 7.15e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 36 DGFDIAIMGFIAPTLKQEWGVSNHQLGFVISAALIGLALGAIFSGPLADWLGRKKIIINSVFFFGFWTIATALSQNIEQM 115
Cdd:cd17372 11 EAMEMMLLSFVGPAVQCEWNLSAWQVALITSVVFAGMMIGSYLWGIVSDKYGRRKGLIISALWTFYAGFLSAFAPNYMWL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 116 MVFRFLTGLGLGAAmPNIGTLVSEYAPERQRSFLITIIFCGFTFGAAAGGFSASWLIPQFGWHSLMLLGGILPLLFAPVL 195
Cdd:cd17372 91 IILRCLVGLGLGGG-PQLASWYLEFLPAKSRGTWMVLFSVFWTVGTIFEASLAWLVMPRLGWRWLLAFSSVPSSLLLVFY 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 196 IWLLPESVRFLVVKRAPAERirrimqrlYPGQIPDEAEFSLPAQPVQANAMRIVLSRQYRFGSMMLWLVYFMGLFLVyll 275
Cdd:cd17372 170 RWTPKTTLLLWVIWFGNAFA--------YYGVVLLTTELNNSHNVCGSKSDSDSGESPTEKQCRNSNDVDYRDVFIA--- 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 276 gswlptlvkevglTVGQAAvmtamyqaggtlGSLFAGWLMDRINPHRALGLIYAVGGLFTMAMGYAAASFALICLLaFIS 355
Cdd:cd17372 239 -------------TFAEFP------------GLLISAAMIDRLGRKASMASMLFTCCIFLLLLLICQSPFILTVLL-FGG 292
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 503994177 356 GACLNGANTGMNALSARYYPTEARATGSSWMHGVGRMGAILSAFAGAEMLALNIS-----FESVFLILGIPA 422
Cdd:cd17372 293 RACISAAFTVVYIYTPEVYPTAVRALGVGTGSSVGRIGAILCPFIAQVLVHGSQTialllFSVVCLVSAICV 364
|
|
| MFS_GLUT6_8_Class3_like |
cd17358 |
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ... |
24-359 |
4.75e-15 |
|
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340916 [Multi-domain] Cd Length: 436 Bit Score: 76.85 E-value: 4.75e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 24 LVVFLGFCVIALDGFDIAIMGFIAPTLKQEWGVSNHQLGFVISAALIGLALGAIFSGPLADWLGRKK-IIINSVFFFGFW 102
Cdd:cd17358 6 VANLGSFSFGIAVGWSSPALPSLMSDNSLSLPLTVAQFSWFGSLLTLGALIGALLSGKLADRIGRKRtLLISAIPCILGW 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 103 tIATALSQNIEQMMVFRFLTGLGLGAAMPNIGTLVSEYAPERQRSFLITIIFCGFTFGAAAGgFSASWLIPqfgWHSLML 182
Cdd:cd17358 86 -LLIAFAKDVWMLYLGRFLAGFGGGAASVVVPVYIAEIAPKNVRGALGSLNQLLVNIGILLG-YVLGSFLP---WRTLAL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 183 LGGILPLLFApVLIWLLPESVRFLVvKRAPAERIRRIMQRLYPGQIPDEAEFSLPAQPVQ-------ANAMRIVLSRQYR 255
Cdd:cd17358 161 IGAIPPVVFL-ILLFFIPESPRWLA-KKGREEEAEKSLQFLRGKDADISKEAAEIQEELAelekeakESSFSDLFQRKYL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 256 FGsmmlwLVYFMGLFLVYLLG------SWLPTLVKEVGLTV--GQAAVMTAMYQAGGTLgslFAGWLMDRInPHRALGLI 327
Cdd:cd17358 239 KP-----LVIGLGLMLFQQLSginaviFYASSIFDEAGSGLdpNTATIIIGVVQVVGTL---VATLLVDRL-GRRPLLLV 309
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 503994177 328 YAVG-GLFTMAMGYAA------------ASFALICLLAFISGACL 359
Cdd:cd17358 310 SAIGmGIGLLALGLYFylqehgallssvSWLPLVGLVIYIISFSI 354
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
25-419 |
6.79e-15 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 76.16 E-value: 6.79e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 25 VVFLGFCVIALDGFDI--AIMGFIAPtLKQEWGVSNHQLGFVISAALIGLALGAIFSGPLADWLGRKKIIINSVFFFGFW 102
Cdd:cd17355 3 VVLAVTFLILILSWGIryYFGVFIIP-IIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 103 TIATALSQNIEQMMVFRFLT-GLGLGAAMPNIGTLVSEYAPERQRSFLITIIFCGFTFGAAAGGFSASWLIPQFGWHSLM 181
Cdd:cd17355 82 LVLLALATSLWQLYLLWGLLgGGGAGTLAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTAL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 182 LLGGILPLLFAPVLIWLLPesvrflvvkRAPAERirrimqrlyPGQIPDEAEFSLPAQPVQAnAMRivlSRQYRFgsmmL 261
Cdd:cd17355 162 LVLALLALLVLVPVLLLLR---------RRPADL---------ALRAYDDASPASPGSTLKE-ALR---SASFWL----L 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 262 WLVYFMGLFLVYLLGSWLPTLVKEVGLTVGQAAVMTAMYQAGGTLGSLFAGWLMDRINPHRALGLIYAVGGLFTMAMGYA 341
Cdd:cd17355 216 ALAFFLCGFAVVGLIVHLVPYLADRGISPAAAAVALALIGLFNIVGRLLSGWLGDRYSPRRLLAASYALRALGLALLLLL 295
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 503994177 342 AASFALICLLAFISGACLNGANTGMNALSARYYPTEARATGSSWMHGVGRMGAILSAFAGAEMLALNISFESVFLILG 419
Cdd:cd17355 296 PFPPLALLLFAALFGLGWGATVPLTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGSYTAAWALAV 373
|
|
| efflux_Bcr_CflA |
TIGR00710 |
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
19-202 |
2.50e-14 |
|
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.
Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 74.34 E-value: 2.50e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 19 SRFQKLVVFLGFCVIALDGFDIAIMGFiaPTLKQEWGVSNHQLGFVISAALIGLALGAIFSGPLADWLGRKKIIINSVFF 98
Cdd:TIGR00710 2 SAKAFALLLGCLSILGPLGIDMYLPAF--PEIAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFI 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 99 FGFWTIATALSQNIEQMMVFRFLTGLGLGAAMPNIGTLVSEYAPERQRSFLITIIFCGFTFGAAAGGFSASWLIPQFGWH 178
Cdd:TIGR00710 80 FALSSLGLALSNNIETLLVLRFVQAFGASAGSVISQALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVWLSWH 159
|
170 180
....*....|....*....|....
gi 503994177 179 SLMLLGGILPLLFAPVLIWLLPES 202
Cdd:TIGR00710 160 AIFAFLSLAGILLSALIFFILPET 183
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
24-201 |
2.71e-14 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 74.15 E-value: 2.71e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 24 LVVFLGFCVialdGFDIAIMGFIAPTLKQEWGVSNHQLGFVISAALIGLALGAIFSGPLADWLGRKKIIINSVFFFGFWT 103
Cdd:cd17323 3 IISFLTFVV----TFGSSIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQ 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 104 IATALSQNIEQMMVFRFLTGLGLGAAMPNIGTLVSEYAPERQRSFLITiIFCGFTF-GAAAGGFSASWLIPQFGWHSLML 182
Cdd:cd17323 79 IGCALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMG-VYSLGPLlGPALGPIIGGFITQSLGWRWIFW 157
|
170
....*....|....*....
gi 503994177 183 LGGILPLLFAPVLIWLLPE 201
Cdd:cd17323 158 FLAIISGFCLILIFLFLPI 176
|
|
| PRK11102 |
PRK11102 |
Bcr/CflA family multidrug efflux MFS transporter; |
48-202 |
4.17e-14 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182964 [Multi-domain] Cd Length: 377 Bit Score: 73.41 E-value: 4.17e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 48 PTLKQEWGVSNHQLGFVISAALIGLALGAIFSGPLADWLGRKKIIINSVFFFGFWTIATALSQNIEQMMVFRFLTGLGLG 127
Cdd:PRK11102 15 PVIAADFGVSAGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFLHGLAAA 94
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 503994177 128 AAMPNIGTLVSEYAPE----RQRSFLITIIFCGFTFGAAAGGFSASWlipqFGWHSLMLLGGILPLLFAPVLIWLLPES 202
Cdd:PRK11102 95 AASVVINALMRDMFPKeefsRMMSFVTLVMTIAPLLAPIIGGWLLVW----FSWHAIFWVLALAAILAAALVFFFIPET 169
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
46-431 |
8.43e-14 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 72.61 E-value: 8.43e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 46 IAPTL----KQEWGVSNHQLGFVISAALIGLALGAIFSGPLADWLGRKKIIINSVFFFGFWTIATALSQNIEQMMVFRFL 121
Cdd:cd17473 18 IAPALpaiaQHFVPNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRAL 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 122 TGLGLGAAMPNIGTLVSEYAPERQRSFLITIIFCGFTFGAAAGGFSASWLIpQFGWHSLMLLGGiLPLLFAPVLIWLLPE 201
Cdd:cd17473 98 LGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALA-EIGWRAPFLVYL-LALPVLILVLLFLPE 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 202 SVRFLVVKRAPAerirrimqrlypgqipDEAEFSLPAQPVQANAMrivlsrqyrfgsmmlwlVYFMGLFLVYLLGSWLPT 281
Cdd:cd17473 176 PARKSKSAASPG----------------AATAAALPWKRVLPIYF-----------------LAFLAMLLFYVIPIQLPF 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 282 LVKEVGLT-VGQAAVMTAMYQAGGTLGSLFAGWLMDRINPHRALGLIYAVgglftMAMGYAAASFALIcLLAFISGACLN 360
Cdd:cd17473 223 LLQERGGGsAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFAL-----MALGFLLLALASG-LWVVLLGAILA 296
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 503994177 361 GANTGM-----NALSARYYPTEARATGSSWMHGVGRMGAILSAFAGAEMLALNISFESVFLILGIPAAITVAGLAA 431
Cdd:cd17473 297 GLGFGLllptlNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLVNLTGGLSGAFLILGVLALVLAIVLLL 372
|
|
| MFS_SV2C |
cd17440 |
Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; ... |
28-286 |
1.20e-13 |
|
Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2C exhibits enriched expression in several basal ganglia nuclei, and has been found to be involved in normal operation of the basal ganglia network and could be also be involved in system adaptation in basal ganglia pathological conditions. SV2C belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340998 [Multi-domain] Cd Length: 479 Bit Score: 72.64 E-value: 1.20e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 28 LGFCVIAlDGFDIAIMGFIAPTLKQEWGVSNHQLGFVISAALIGLALGAIFSGPLADWLGRKKIIINSVFFFGFWTIATA 107
Cdd:cd17440 4 LGMALMA-DGVEVFVVGFVLPSAETDMCIPNSGSGWLGSIVYLGMMVGAFFWGGLADKVGRRQSLLICMSVNGFFAFLSS 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 108 LSQNIEQMMVFRFLTGLGLGAAMPNIGTLVSEYAPERQRSFLITIIFCGFTFGAAAGGFSASWLIPQFGW---------- 177
Cdd:cd17440 83 FVQGYGLFLFCRLLSGFGIGGAVPTVFSYFAEVLAREKRGEHLSWLCMFWMIGGIYASAMAWAIIPHYGWsfsmgsayqf 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 178 HS--LMLLGGILPLLFAPVLIWLLPESVRFL--VVKRAPAERIRRimqrlypgQIPDeAEFSLPAQPVQAnamrIVLSRQ 253
Cdd:cd17440 163 HSwrVFVIVCALPCVSSVVALTFMPESPRFLleVGKHDEAWMILK--------QIHD-TNMRARGQPEKV----FTVNRI 229
|
250 260 270
....*....|....*....|....*....|...
gi 503994177 254 YRFGSMMLWLVYFMGLFLVYLLGSWLPTLVKEV 286
Cdd:cd17440 230 KKDNTIKLTIVWLTLSFGYYGLSVWFPDVIKHL 262
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
26-199 |
1.21e-13 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 72.22 E-value: 1.21e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 26 VFLGFCVIALDGFDIAIMGFIAPT-LKQEWGVSNHQLGFVISAALIGLALGAIFSGPLADWLGRKKIIINSVFFFGFWTI 104
Cdd:cd17325 201 LLALFLAIFVLAFAFGALEPFLPLyAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALL 280
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 105 ATALSQNIEQMMVFRFLTGLGLGAAMPNIGTLVSEYAPERQRSFLITIIFCGFTFGAAAGGFSASWLIPQFGWHSLMLLG 184
Cdd:cd17325 281 LLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAA 360
|
170
....*....|....*
gi 503994177 185 GILPLLFAPVLIWLL 199
Cdd:cd17325 361 AALLLLAAVLFLLLR 375
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
44-427 |
1.27e-13 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 72.26 E-value: 1.27e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 44 GFIAPTLKQEWGVSNHQLGFVISAALIGLALGAIFSGPLADWLGRKKIIINSVFFFGFWTIATALSQNIEQM-MVFRFLT 122
Cdd:cd17353 23 SVFNPPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGLGFILSAFAISLPLLfLGYGVLG 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 123 GLGLGAAMPNIGTLVSEYAPERqRSFLITIIFCGFTFGAAAGGFSASWLIPQFGWHSLMLLGGILPLLFAPVLIWLLpes 202
Cdd:cd17353 103 GIGAGIGYITPVSTAVKWFPDK-RGLATGIVIAGFGLGSLIFSPLIAYLINTVGVPTTFLILGIIFLIIIVIGAFLI--- 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 203 vrflvvkRAPAERIRRimqrlyPGQIPDEAEFSLPAQPVQANAMrivlSRQYRFgsMMLWLVYFMGLF-LVYLLGSWLPT 281
Cdd:cd17353 179 -------RDPPKGWVP------PGVDPLANNAENSPRDYTPREM----LRTPTF--WLLWLMFFLNATaGLMLIGQAKPI 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 282 LVKEVGLTVGQAAVMTAMYQAGGTLGSLFAGWLMDRINPHRALGLIYAVGGLFTMAMGYAAASFALICLLAFISGACLNG 361
Cdd:cd17353 240 GQEFAGLDAGIAALAVSILSIFNGGGRPFWGWLSDKIGRKNTLSIAFLIQGVAMFLLPFIGSVAVLFVLGVALIGFCYGG 319
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 503994177 362 ANTGMNALSARYYPTEARATGSSWMHGVGRMGAILSAFAGAeMLALNISFESVFLILGIPAAITVA 427
Cdd:cd17353 320 GFALFPALTADFFGTKNAGTNYGLLYTAKGVGGLIGPIIAA-YVLYTGGYNAAFIIAAALSLVALA 384
|
|
| MFS_GLUT10_12_Class3_like |
cd17362 |
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ... |
55-205 |
3.26e-13 |
|
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340920 [Multi-domain] Cd Length: 389 Bit Score: 70.84 E-value: 3.26e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 55 GVSNHQLGFVISAALIGLALGAIFSGPLADWLGRKKIIINSVFFFGFWTIATALSQNIEQMMVFRFLTGLGLGAAMPNIG 134
Cdd:cd17362 35 NLSSLQSGLVVSGSLLGALLGSLVAGALIDRLGRRKELILAALLYLVGSLVTGLAPSYPVLLVGRLIYGVGIGLAMHAAP 114
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 503994177 135 TLVSEYAPERQRSFLITIIFCGFTFGAAAGGFSASWLIPQFGWHSLMLLGGILPLLFAPVLIWLLPESVRF 205
Cdd:cd17362 115 VYIAETSPSHIRGLLVSLKELFIVLGILLGYVSGYAFADVVGGWRYMYGLAAPPALLLGIGMWFLPPSPRW 185
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
70-202 |
5.87e-13 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 65.75 E-value: 5.87e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 70 IGLALGAIFSGPLADWLGRKKIIINSVFFFGFWTIATALSQNIEQMMVFRFLTGLGLGAAMPNIGTLVSEYAPERQRSFL 149
Cdd:TIGR00880 9 LGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIYPPEERGVA 88
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 503994177 150 ITIIFCGFTFGAAAGGFSASWLIPQFGWHSLMLLGGILPLLFAPVLIWLLPES 202
Cdd:TIGR00880 89 LGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLPET 141
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
47-359 |
7.65e-13 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 69.96 E-value: 7.65e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 47 APTLKQEWGVSNHQLGFVISAALIGLALGAIFSGPLADWLGRKKI---------IINSVFFFGFWTIATALSqnieqMMV 117
Cdd:cd17345 26 QPYLIEQYGLSKTEIGLIGSALSIAYGLSKFVMGNLSDRSNPKRFlaiglilsaIINILIGFVPSATSSVGL-----MFI 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 118 FRFLTGLGLGAAMPNIGTLVSEYAPERQRSFLITIIFCGFTFGAAAGGFSASWLIPQFG---WHSLMLLGGILPLLFApV 194
Cdd:cd17345 101 LLFLNGWFQGMGWPPSGRTMVHWFSKKERGTWTSIWNISHNVGGGLVGPLAGLGLAIFGdgwWRGAFIFPAIIAIIVA-V 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 195 LIWLL----PESVRFlvvkrAPAERIRrimqrlypGQIPDEAEFSlpAQPVQANAMRIVlsRQYRFGSMMLWLVYFMGLF 270
Cdd:cd17345 180 IVLFLgkdtPESEGL-----PPIEEYK--------GDYPEEADGE--EEEQELSAWEIF--VKYVLKNKLLWYIAIANVF 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 271 lVYLLG----SWLPTLVKEV-GLTVGQAAVMTAMYQAGGTLGSLFAGWLMDRINP-HRALGLIYAVGGLFTMAMGYAAAS 344
Cdd:cd17345 243 -VYLVRygilDWAPTYLSEVkGFSKAQAMWAFSLFEWAAIPGTLLAGWLSDKLFKgRRAPTGIIFMILVIVALIVYWLAP 321
|
330
....*....|....*
gi 503994177 345 FALICLLAFISGACL 359
Cdd:cd17345 322 NVLVDLIALIALGFL 336
|
|
| MFS_GLUT_Class1_2_like |
cd17357 |
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ... |
62-427 |
1.78e-12 |
|
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340915 [Multi-domain] Cd Length: 447 Bit Score: 68.83 E-value: 1.78e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 62 GFVISAALIGLALGAIFSGPLADWLGRKKIIINSVFFFGFWTIATALS---QNIEQMMVFRFLTGLGLGAAMPNIGTLVS 138
Cdd:cd17357 52 SLIVSIFFIGGAIGSFISAFLANRFGRKNGLLISNALLVVSSLLMFLSksaKSPELLIFGRFLVGIACGLSTGFVPMYLQ 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 139 EYAPERQRSFLITIIFCGFTFGAAAGGFSA--SWLIPQFGWHsLMLLGGILPLLFAPVLIWLLPESVRFLVVKRAPAERI 216
Cdd:cd17357 132 EISPSELRGALGSLTQIGVTLGILLGQVFGlpSVLGTETLWP-YLLFFPGIPALLQLAALPFFPESPKFLLISKGDEEEA 210
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 217 RRIMQRLYPGQIPDEAEF------SLPAQPVQANAMRIVL-SRQYRFGSMMLWLVYFMGLFL-VYLLGSWLPTLVKEVGL 288
Cdd:cd17357 211 EKSLKFLRGIEDDVDQELeeikkeSEQMGDQKQVSLMQLLrDPSLRLPLLLVLVVSASQQFSgINAIFFYSTFIFENAGF 290
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 289 TVGQAAVMTAMYQAGGTLGSLFAGWLMDRInPHRALGLI-YAVGGLFTMAMGYAAASFALICLLAFISGACL----NGAN 363
Cdd:cd17357 291 SPQLAEWANLGIGIVNVLSTIVGPFLIEKV-GRRPLLLIsLSVCAVALLLMSVFLFLSEQNSWMSYGCIVAIflfiFFFA 369
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 503994177 364 TGMNALS----ARYYPTEARATGSSWMHGVGRMGAILSAFagAEMLALNISFESVFLILGIPAAITVA 427
Cdd:cd17357 370 IGLGPIPwfigAELFPQAPRSAAQSLGSSVNWTSNFIVGM--AFPPLQSIGGGFVFIIFAIPCALFLL 435
|
|
| MFS_SV2B |
cd17438 |
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; ... |
26-431 |
2.10e-12 |
|
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2B is a key modulator of amyloid toxicity at the synaptic site and also has an essential role in the formation and maintenance of the glomerular capillary wall. SV2B belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340996 [Multi-domain] Cd Length: 477 Bit Score: 68.80 E-value: 2.10e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 26 VFLGFCVIAlDGFDIAIMGFIAPTLKQEWGVSNHQLGFVISAALIGLALGAIFSGPLADWLGRKKIIINSVFFFGFWTIA 105
Cdd:cd17438 2 FVLGLALMA-DGVEVFVVGFVLPSAEKDMCLSSSNKGMLGLIVYLGMMAGAFIWGGLADKLGRKRCLIISLAINASFAFL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 106 TALSQNIEQMMVFRFLTGLGLGAAMPNIGTLVSEYAPERQRSFLITIIFCGFTFGAAAGGFSASWLIPQFGW-------- 177
Cdd:cd17438 81 SSFVQGYGAFLFCRLISGFGIGGSLPIVFAYFSEFLAREKRGEHLSWLCMFWMIGGLYASAMAWSIIPHYGWgfsmgtny 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 178 --HS--LMLLGGILPLLFAPVLIWLLPESVRFLvVKRAPAERIRRIMQRLYpgqipdEAEFSLPAQPVQAnamrIVLSRQ 253
Cdd:cd17438 161 hfHSwrVFVIICALPCIASIIALKFMPESPRFL-LEMGKHDEAWMILKNIH------DTNMRAKGTPEKV----FTVSNI 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 254 YRFGSMMLWLVYFMGLFLVYLLGSWLPTLVKEVGLTVG--------------------------QAAVM--TAMYQAG-- 303
Cdd:cd17438 230 KRKNTLFLAVVWFTMAFSYYGLTVWFPDMIRYLQKHVTfedslfdecyfedvtstdtyfknctiESTIFynTDLYEHKfi 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 304 ----------------------------------GTL----GSLFAGWLMDRINPHRALG---LIYAVGGLFTMAMGYAA 342
Cdd:cd17438 310 dcrfinstfleqkegchmdfeedndfliylvsflGSLsvlpGNIISALLMDKIGRIKMIGgsmLISAVCCFFLFFGNSES 389
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 343 ASFALICLLAFISGACLNgantGMNALSARYYPTEARATGSSWMHGVGRMGAILsafaGAEMLALNISFESVFLILGIPA 422
Cdd:cd17438 390 AMIGWQCLFCGTSIAAWN----ALDVITVELYPTNKRATAFGILNGLCKFAAIL----GNSIFASFVGITKVIPILLAST 461
|
....*....
gi 503994177 423 AITVAGLAA 431
Cdd:cd17438 462 ALVGGGLIS 470
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
30-386 |
2.71e-12 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 67.97 E-value: 2.71e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 30 FCVIALDGFDIAIMGFIAPTLKQEWGVSNHQLGFVISAALIGLALGAIFSGPLADWLGRKKIIINSVFFFGFWTIATALS 109
Cdd:cd17477 2 LLSVALLGLGSGLLLPLLSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALT 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 110 QNIEQMMVFRFLTGLGLGAAMPNIGTLVSEYAPERQRSFLITIIFCGFTFGAAAGGFSASWlIPQFGWHSLMLLGGILPL 189
Cdd:cd17477 82 DSPWVWFLLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLLLAL-VGTAGALPFLIAAVLLLL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 190 LFAPVLiwllpesvrflvvkrapaerirrimqrlypgqipdeaeFSLPAQPVQANAMRIVLSRQYRFGSMMLWLVYFMGL 269
Cdd:cd17477 161 ALVPLL--------------------------------------LTRRAAPEIEEAESISLRRLLRIAPLALLGAFVAGF 202
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 270 FLVYLLGSwLPTLVKEVGLTVGQAAVMTAMYQAGGTLGSLFAGWLMDRINPHRALGLIYAVGGLFTMAMGYAAASFALIC 349
Cdd:cd17477 203 LEGAFYSL-LPLYGLRLGLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCALLGALAALLLPLVPGLPLALL 281
|
330 340 350
....*....|....*....|....*....|....*..
gi 503994177 350 LLAFISGACLNGANTGMNALSARYYPTEARATGSSWM 386
Cdd:cd17477 282 VLLFLWGGAAGPLYTLALALAGDRLPGDELVAANAAL 318
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
260-430 |
2.94e-12 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 67.98 E-value: 2.94e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 260 MLWLVYFMGLFLVYLLGSWLPTLVKEVGLTVGQAAVMTAMYQAGGTLGSLFAGWLMDRINPHRALGLIYAVGGLFTMAMG 339
Cdd:COG2223 9 LATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLA 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 340 YAAaSFALICLLAFISGACLNGANTGMNALSARYYPTEARATGSSWMHGVGRMGAILSAFAGAeMLALNISFESVFLILG 419
Cdd:COG2223 89 LAV-SYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAP-LLIAAFGWRNAFLILG 166
|
170
....*....|.
gi 503994177 420 IPAAITVAGLA 430
Cdd:COG2223 167 ILLLVVAVLAW 177
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
52-427 |
3.07e-12 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 67.62 E-value: 3.07e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 52 QEWGVSNHQLGFVISAALIGLALGAIFSGPLADWLGRKKIIINSVFFFGFWTIATALSQNIEQMMVFRFLTGLGLGAAMP 131
Cdd:cd17489 24 HDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTT 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 132 NIGTLVSEYAPERQRSFLITIIFCGFTFGAAAGGFSASWLIPQFGWHSLMLLGGILPLLfAPVLIWLLPEsvrflvvkra 211
Cdd:cd17489 104 AAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALL-ALLLVFLVKD---------- 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 212 paerirrimqrlypgqipdeaefSLPAQPVQANAMRIVLSRQYRFGSMMLWLVYFMGLFLVYLLGSWLPTLVKEVGLTvg 291
Cdd:cd17489 173 -----------------------PPPVAAEEAEAGTRAFRRLVEKKVLPPALILFLASIAYGAISTFLPLYAAERGIS-- 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 292 QAAVMTAMYQAGGTLGSLFAGWLMDRINPHRALGLIYAVGGLFTMAMGyAAASFALICLLAFISGACLNGANTGMNALSA 371
Cdd:cd17489 228 NAGLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLS-FAGSPWMLLLAAVLYGLGFGLLFPALQALAV 306
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 503994177 372 RYYPTEARATGSSWMHGVGRMGAILSAFAGAeMLALNISFESVFLILGIPAAITVA 427
Cdd:cd17489 307 DLVPPHRRGAANGTFFIFFDLGIGLGGLLLG-LVAELFGYRAMFLLAAVVVLLALV 361
|
|
| MFS_HMIT_like |
cd17360 |
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ... |
63-211 |
3.71e-12 |
|
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340918 [Multi-domain] Cd Length: 362 Bit Score: 67.30 E-value: 3.71e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 63 FVISAALIGLALGAIFSGPLADWLGRKKIIINSVFFFGFWTIATALSQNIEQMMVFRFLTGLGLGAAMPNIGTLVSEYAP 142
Cdd:cd17360 39 LIVSSTVAGAAVGAAIGGWLNDRFGRRPCILLADALFTIGAIVMAAAPNKEVLIVGRVLVGLGVGIASMTVPLYIAEAAP 118
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 143 ERQRSFLITIIFCGFTFGA-AAGGFSASWLIPQFGWHSLMLLGGILPLLFAPVLIWlLPESVRFLVVKRA 211
Cdd:cd17360 119 PRIRGRLVTINVLFITGGQfVAYVINGAFSYLPGGWRWMLGLAAVPAVLQFIGLLF-LPESPRWPSTRRA 187
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
48-431 |
6.94e-12 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 66.83 E-value: 6.94e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 48 PTLKQEWGVSNHQLGFVISAALIGLALGAIFSGPLADWLGRKKIIINSVFFFGFWTIATALSQNIEQMMVFRFLTGLGlG 127
Cdd:cd17504 20 PTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAGRALQGIG-G 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 128 AAMPNIGTLVSEYAPERQRSFLITIIFCGFTFGAAAGGFSASWLIPQFGWHSLMLLGGILPLLFAPVliwllpesvrflv 207
Cdd:cd17504 99 AVFPLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVAVLLAAL------------- 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 208 vkrAPAERIRRIMQRlypgqipdeaefslpaQPVQANAMRIVLSrqyrFGSMMLwlvyFMGLFLVYLLGSWLPtlvkeVG 287
Cdd:cd17504 166 ---VPLIDLRLLRRR----------------NVLLANITALLAG----FGMFMV----FQLLPQLLQLPTPTG-----FG 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 288 LTVGQAAVMTAMYQAGGTLGSLFAGWLMDRINPHRALGLIYAVGGLFTMAMGYAAASFALICLLAFISGACLNGANTGMN 367
Cdd:cd17504 214 LGITEAGLLLLPGALVMLIAGPLAGRLIARVGPRRVLLIGLVISAVGLLLLALLHSSLWALVVALLLIGIGLGLAFASLP 293
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 503994177 368 ALSARYYPTE-----------ARATGSSWmhGVGRMGAILSAFAGAEMLALNISFESVFLILGIPAAITVAGLAA 431
Cdd:cd17504 294 NIVVESVPPDrtgiatgmntvLRTIGSAI--GPAIAGAILTTYTVSITSGGVPTEGAYVLAFLIGAALALAALLL 366
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
48-424 |
7.82e-12 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 66.43 E-value: 7.82e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 48 PTLKQEWGVSNHQLGFVISAALIGLALGAIFSGPLADWLGRKKIIINSVFFFGFWTIATALSQNIEQMMVFRFLTGLGLG 127
Cdd:cd17478 20 PLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGIGSA 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 128 AAMPNIGTLVSEYAPERqRSFLITIIFCGFTFGAAAGGFSASWLIPQFGWHSLMLLGgILPLLFAPVLIWLLPESVRFLV 207
Cdd:cd17478 100 AFHPEGARLASQAAGGR-RGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILL-IIPGLAVALLLLRLRPLKKPEA 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 208 VKRAPAERIRRimqrlypgqipdeaefslpaqpvqanamrivLSRQYRFGSMMLWLVYFMGLFLVYLLGSWLPTLVKEVG 287
Cdd:cd17478 178 KKAAAKSSARS-------------------------------TLKGVWRALLLLLIIVFLRSWVLSSLTTFLPFYLVQRG 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 288 LTVGQAAVMTAMYQAGGTLGSLFAGWLMDRINPHRALGLIYAVGGLFTMAMgyAAASFALICLLAFISGACLNGANTGMN 367
Cdd:cd17478 227 YSLVFAGLLLSLFLFAGAIGTLIGGPLSDRFGRRRVIIASLLLAAPFLLLF--LLTPGIWSYILLVLAGFLLFASFPVTV 304
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 503994177 368 ALSARYYPtEARATGSSWMHGVG-RMGAILSAFAGAemLALNISFESVFLILGIPAAI 424
Cdd:cd17478 305 VLAQELLP-GNVGLASGLMMGLSfGLGGIGAPVLGA--LADAFGLESVLLILALLPLL 359
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
14-420 |
9.86e-12 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 66.46 E-value: 9.86e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 14 NANPLSRFQKLVVFLGFcvIALDGFDIAIMGFIAPTLKQEWGVSNHQLGFVISAALIGLALGAIFSGPLAD----WLGRK 89
Cdd:COG2211 3 AKKKLSLKEKLAYGLGD--LGLNLAFGLLSAYLLYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDrtrtRWGRR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 90 K------IIINSVFFFG-FWTIATALSQNIEQMMVFRFLTGLGLGAAMPNIGTLVSEYAPE-RQRSFLITIIFCGFTFGA 161
Cdd:COG2211 81 RpwiligAIPLALSFVLlFTAPDLSPTGKLIYALVTYLLLGLAYTLVNIPYSALGAELTPDyEERTRLSSWRFAFAGLGG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 162 AAGGFSASWLIPQF------GWHSLMLLGGILPLLFAPVLIWLLPESVRFLVVKRAPAERIRRIMQrlypgqipdeaefs 235
Cdd:COG2211 161 LLASVLPPPLVAAFggdaalGYRLTALIFAVLGLLAFLLTFFGTKERPVPEEEKVSLKESLKALLK-------------- 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 236 lpaqpvqanamrivlSRQYRfgsmMLWLVYFMGLFLVYLLGSWLPTLVKEV-GLTVGQAAVMTAMYQAGGTLGSLFAGWL 314
Cdd:COG2211 227 ---------------NRPFL----LLLLAYLLFFLALALVAALLLYYFKYVlGLSAALVGLLLALYFLAALLGAPLWPRL 287
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 315 MDRINPHRALGLIYAVGGLFTMAMGYA-AASFALICLLAFISGACLNGANTGMNALSARyypteaRATGSSWMHGVGRMG 393
Cdd:COG2211 288 AKRFGKKKAFIIGLLLAALGLLLLFFLgPGNLWLLLVLAALAGIGLGAILVLPWAMLAD------VVDYDEWKTGRRREG 361
|
410 420
....*....|....*....|....*..
gi 503994177 394 AILSAFAGAEMLALNISFESVFLILGI 420
Cdd:COG2211 362 LYFGIFTFAIKLGQALAGALAGLLLAL 388
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
251-430 |
1.25e-11 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 66.03 E-value: 1.25e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 251 SRQYRFGSMMLWLVYFMGLFLVYLLGSWLPTLVKEVGLTVGQAAVMTAMYQAGGTLGSLFAGWLMDRINPHR--ALGLIY 328
Cdd:COG0738 3 KKNYRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRglLLGLLL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 329 AVGGLFTMAMgyaAASFALICLLAFISGACLNGANTGMNALSARYYPtEARATGSSWMHGVGRMGAILSAFAGAEMLALN 408
Cdd:COG0738 83 MALGLLLFAL---APSYPLLLLALFLLGLGLGLLDVAANPYVAALGP-ETAASRLNLLHAFFSLGALLGPLLGGLLILLG 158
|
170 180
....*....|....*....|....
gi 503994177 409 ISFE--SVFLILGIPAAITVAGLA 430
Cdd:COG0738 159 LSLSwhLPYLILAVLLLLLALLFL 182
|
|
| MFS_SLC37A4 |
cd17343 |
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ... |
45-433 |
1.55e-11 |
|
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340901 [Multi-domain] Cd Length: 409 Bit Score: 65.82 E-value: 1.55e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 45 FIAPTLKQEWGVSNHQLGFVISAALIGLALGAIFSGPLADWLGRKKIIINSVFFFGFWTIATALSQNIEQMMVFRFLTGL 124
Cdd:cd17343 24 FVLPSLMNELGLDKSDLGLITSSQSLAYAISKFIGGVLSDQISARWLFSSGLVLSGLTTVAFSGSSSVWVFSILWFLNGL 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 125 GLGAAMPNIGTLVSEYAPERQRSFLITIIFCGFTFGAAAGGFSASWLIPQFGWHSLMLLGGILPLLFAPVLiwllpesvr 204
Cdd:cd17343 104 AQGLGWPPCAKILRKWFSPSQFGTWWSVLSTSMNLAGSLGPILATLLALSYGWRSTLSISGTVAVVMSVVC--------- 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 205 FLVVKRAPAERIRRImqrlypgqipdeaEFSLPAQPVQANAMRIVLSRQYRFGSMMLWLVYF--MGLFLV---YLLGSWL 279
Cdd:cd17343 175 LLFIKNEPSDVGLNN-------------IEEEESKGKKKKSPRGESTLKELLLSPFLWLLSLgyLVVFGVktaVTDWGQL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 280 pTLVKEVGLTVGQAAVMTAMYQAGGTLGSLFAGWLMDRI----------NPHRALGLIYAVG-----GLFTMAMGYAAAS 344
Cdd:cd17343 242 -FLIQDKGQSALTGSSFMSSLEVGGFVGSIAAGYLSDWAvakhgsssrgNPRMPLALVFMAGltvslHLFRVHITSDSSE 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 345 FAlICLLAFISGACLNGANTGMNALSARYYPTEARATGSSWMHGVGRMGAILSAFAgAEMLALNISFESVFLILGIPAAI 424
Cdd:cd17343 321 LF-ILLLGFLIGFSLYGPIAIFGVIANESAPSHLCGTSHAIVALAANVGGVLAGLP-FSYIAKHYDWRTAFLLLEILCAI 398
|
....*....
gi 503994177 425 TVAGLAAKG 433
Cdd:cd17343 399 TVVILFLLR 407
|
|
| MFS_HXT |
cd17356 |
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ... |
25-206 |
1.79e-11 |
|
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340914 [Multi-domain] Cd Length: 403 Bit Score: 65.73 E-value: 1.79e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 25 VVFLGFcviaLDGFDIAIMGFI--APTLKQEWGVSNH-------QLGFVISAALIGLALGAIFSGPLADWLGRKKIIINS 95
Cdd:cd17356 6 VSLGGF----LFGYDTGSISGIlnMKSFQKYFADNTGtyypsssRQGLIVSIVNLGSFFGALISSFLSDRIGRKKSIQIG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 96 VFFFGFWTIATALSQN-IEQMMVFRFLTGLGLGAAMPNIGTLVSEYAPERQRSFLITI--------IFCGF--TFGAAAG 164
Cdd:cd17356 82 CVIYIIGAIIQVAAIGkWYQLIVGRIIAGLGVGFASVLVPVYQSEVAPKHIRGTLVSLyqlaitigILVAYciNYGTHKL 161
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 503994177 165 GFSASWLIP---QFGWHSLMLLGgilpllfapvlIWLLPESVRFL 206
Cdd:cd17356 162 DGSAQWRIPlglQIVWGLLLLIG-----------MFFLPESPRWL 195
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
40-401 |
2.04e-11 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 65.04 E-value: 2.04e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 40 IAIMGFIAPTLKQEWGVSNHQLGFVISAALIGLALGAIFSGPLADWLGRKKIIINSVFFFGFWTIATALSQNIEQMMVFR 119
Cdd:cd17333 12 DALLGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVVLM 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 120 FLTGLGLGAAMPNIGTLVSEYAPERQRSFLITIIFCgFTFGAAAGGFSASWLIPQFGWHSLMLLgGILPLLFAPVLIWLL 199
Cdd:cd17333 92 FLAGLGAGILDTGANTFVGALFEESSATRLNVLHGF-FGLGALIGPLIATSLLTSELSWSWAYL-IIGLIYLLLAILILL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 200 PESvrflvvkrapaerirrimqrlypgqipDEAEFSLPAQPVQANAMRIVLSRQYRFGSMMLWLVYFMGLFLVYLLGSWL 279
Cdd:cd17333 170 TLF---------------------------PELPSARNPQQSVGAFSASASRLLRNPSIILGALALFLYVGAETAFSSWV 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 280 PTLVKEV-GLTVGQAAVMTAMYQAGGTLGSLFAGWLMDRINPHRALgLIYAVGGLFTMAMGYAAASFALICLLAFISGAC 358
Cdd:cd17333 223 PSYLVEKkHVSDGLAGYLLSGFWVGITIGRLLGGPISRRIKPHTLL-VLSGSGALLGLLILLLAPTLVVGLVATALLGLF 301
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 503994177 359 LNGANTGMNALSARYYPTEARATGSSWMHGVGRMGAILSAFAG 401
Cdd:cd17333 302 MAALFPTILSLGISNLPYAKGKGTSVLLAAGSIGGAIIPFIMG 344
|
|
| MFS_SV2A |
cd17439 |
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; ... |
28-419 |
2.14e-11 |
|
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. It is unclear how SV2A is involved in correct SV function, but it has been suggested to either act as a transporter or a regulator of exocytosis by mediating Ca2+ dynamics. SV2A has been identified as the molecular target of the antiepileptic drug levetiracetam (LEV). Its expression is decreased in patients with epilepsy and in epileptic animal models. SV2A belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340997 [Multi-domain] Cd Length: 478 Bit Score: 65.82 E-value: 2.14e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 28 LGFCVIAlDGFDIAIMGFIAPTLKQEWGVSNHQLGFVISAALIGLALGAIFSGPLADWLGRKKII-----INSVFFFgfw 102
Cdd:cd17439 4 LGLALMA-DGVEVFVVGFVLPSAEKDMCLSDSNKGMLGLIVYLGMMVGAFLWGGLADRIGRRQCLlislsVNSVFAF--- 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 103 tiATALSQNIEQMMVFRFLTGLGLGAAMPNIGTLVSEYAPERQRSFLITIIFCGFTFGAAAGGFSASWLIPQFGW----- 177
Cdd:cd17439 80 --FSSFVQGYGTFLFCRLLSGVGIGGSIPIVFSYFSEFLAQEKRGEHLSWLCMFWMIGGIYASAMAWAIIPHYGWsfqmg 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 178 -----HS--LMLLGGILPLLFAPVLIWLLPESVRFLvVKRAPAERIRRIMQRLYpgqipdEAEFSLPAQPVQANAMRIVL 250
Cdd:cd17439 158 sayqfHSwrVFVLVCAFPSVFAIGALTTMPESPRFF-LENGKHDEAWMVLKQVH------DTNMRAKGHPERVFSVTHIK 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 251 SRQyrfgSMMLWLVYFMGLFLVYLLGSWLPTLVKEVGLTV---------------------------------------- 290
Cdd:cd17439 231 RRI----TLMMMAVWFTMSFSYYGLTVWFPDMIKHLQKSVvfedslfeecyfeditssntffknctfistlfyntdlfey 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 291 -------------------------GQAAVMTAMYQAGGTL----GSLFAGWLMDRINPHRALG---LIYAVGGLFTMAM 338
Cdd:cd17439 307 kfinsklinstflhnkegclldfsdENNAYMIYFVSFLGTLavlpGNIVSALLMDKIGRLRMLAgssVMSCVSCFFLSFG 386
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 339 GYAAASFALICLLAFISGACLNgantGMNALSARYYPTEARATGSSWMHGVGRMGAIL-----SAFAGAEMlALNISFES 413
Cdd:cd17439 387 NSESAMIALLCLFGGVSIASWN----ALDVLTVELYPSDKRTTAFGFLNALCKLAAVLgisifTSFVGITK-AVPILLAS 461
|
....*.
gi 503994177 414 VFLILG 419
Cdd:cd17439 462 AALAAG 467
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
35-204 |
2.55e-11 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 64.95 E-value: 2.55e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 35 LDGFDIAImgfIAPTLKQEWGVSNHQLGFVISAALIGLALGAIFSGPLADWLGRKKIIINSVFFFGFWTIATALSQNIEQ 114
Cdd:cd17328 13 MDRFTIAG---VLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQ 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 115 MMVFRFLTGLGLGAAMPNIGTLVSEYAPERQRSFLITIIFCGFTFGAAAGGFSASWLIPQF-GWHSLMLLGGILPLLFAP 193
Cdd:cd17328 90 LLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATgGWRWAFRVTGVLGVLLAI 169
|
170
....*....|.
gi 503994177 194 VLIWLLPESVR 204
Cdd:cd17328 170 LLLLFVREPPR 180
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
49-200 |
2.84e-11 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 64.52 E-value: 2.84e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 49 TLKQEWGV---SNHQLGFVISAALIGLALGAIFSGPLADWLGRKKIIINSVFFFGFWTIATALSQNIEQMMVFRFLTGLG 125
Cdd:cd17317 12 TIVTEWDLvcdRDWLVALVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVT 91
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 503994177 126 LGAAMPNIGTLVSEYAPERQRSFLITIIFCGFTFGAAAGGFSASWLIPqfgWHSLMLLGGILPLLFAPvLIWLLP 200
Cdd:cd17317 92 SAGIFTVGFVLGMEIVGPKYRSFVGILFGLFWALGYMLLALLAYLIRD---WRWLQLAISLPGLLFLL-LLWWLP 162
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
25-204 |
3.97e-11 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 64.12 E-value: 3.97e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 25 VVFLGFCVIALDGFDIAIMGFIAPTLKQEWGVSNHQLGFVISAALIGLALGAIFSGPLADWLGR--KKIIINSVFFFGFW 102
Cdd:COG2271 182 FWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRrrKLVLAIGLLLAALA 261
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 103 TIATALSQNIEQMMVFRFLTGLGLGAAMPNIGTLVSEYAPERQRSFLITIIFCGFTFGAAAGGFSASWLIPQFGWHSLML 182
Cdd:COG2271 262 LLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFL 341
|
170 180
....*....|....*....|..
gi 503994177 183 LGGILPLLFAPVLIWLLPESVR 204
Cdd:COG2271 342 LLAALALLAALLALLLLRETRK 363
|
|
| MFS_OAT |
cd17374 |
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ... |
69-200 |
7.01e-11 |
|
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340932 [Multi-domain] Cd Length: 341 Bit Score: 63.46 E-value: 7.01e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 69 LIGLALGAIFSGPLADWLGRKKIIINSVFFFGFWTIATALSQNIEQMMVFRFLTGLGLGAAMPNIGTLVSEYAPERQRSF 148
Cdd:cd17374 45 MAGLLVGALIFGHLSDRFGRKFILLLSLLQLAIFGTCAAFAPTFPVYCVLRFLAGFAVSGISINTLILGTEWTTPRHRAL 124
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 503994177 149 LITIIFCGFTFGAAAGGFSAsWLIPQfgWHSLMLLGGILPLLFApVLIWLLP 200
Cdd:cd17374 125 AITLTSCFFSIGQMLLAGLA-YAIRD--WRLLQLVVSVPFFLFF-LYSWWLP 172
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
251-430 |
7.54e-11 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 63.45 E-value: 7.54e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 251 SRQYRFGSMMLWLVYFMGLFLVYLLGSWLPTLVKEVGLTVGQAAVMTAMYQAGGTLGSLFAGWLMDRINPHRALGLIYAV 330
Cdd:COG2814 5 PRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 331 GGLFTMAMGyAAASFALICLLAFISGACLNGANTGMNALSARYYPTEARATGSSWMHGVGRMGAILSAFAGAeMLALNIS 410
Cdd:COG2814 85 FALGSLLCA-LAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGG-LLADLFG 162
|
170 180
....*....|....*....|
gi 503994177 411 FESVFLILGIPAAITVAGLA 430
Cdd:COG2814 163 WRWVFLVNAVLALLALLLLL 182
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
62-200 |
8.26e-11 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 63.41 E-value: 8.26e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 62 GFVISAALIGLALGAIFSGPLADWLGRKKIIINSVFFFGFWTIATALSQNI-EQMMVF-RFLTGLGLGAAMPNIGTLVSE 139
Cdd:cd17318 59 GIILSSFFYGYILTQIPGGYLAEKYGAKRVLGYSILITALLTLLTPLAARGgYGALIVlRILQGLAQGVTFPAMHALWAK 138
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 503994177 140 YAPERQRSFLITIIFCGFTFGAAAGGFSASWLIPQFGWHSLMLLGGILPLLFAPVLIWLLP 200
Cdd:cd17318 139 WAPPLERSRLTSIAYSGSQFGTVIAMPLSGFLCESLGWPSIFYIFGGLGLLWCLLWFFLVL 199
|
|
| MFS_PhT |
cd17364 |
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This ... |
35-420 |
1.33e-10 |
|
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of predominantly fungal and plant high-affinity inorganic phosphate transporters (PhT or PiPT), which are involved in the uptake, translocation, and internal transport of inorganic phosphate. They also function in sensing external phosphate levels as transceptors. Phosphate is crucial for structural and metabolic needs, including nucleotide and lipid synthesis, signalling and chemical energy storage. The Pht subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340922 [Multi-domain] Cd Length: 389 Bit Score: 62.68 E-value: 1.33e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 35 LDGFDIAIMGFIAPTLKQEWGV-----SNHQLGFVISAALIGLALGAIFSGPLADWLGRKKIIINSVFFFGFWTIATALS 109
Cdd:cd17364 10 TDAYDLFSISLVTKILGRLYYGgkgslPSGVSGLVNAAALVGTIIGQLFFGFLGDRFGRKRVYGVELIIMIIGTILSALS 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 110 QNIE------QMMVFRFLTGLGLGAAMPNIGTLVSEYAPERQRSFLITIIFCGFTFGAAAGGFsaswlipqfgwhslmlL 183
Cdd:cd17364 90 PGSTplgvmgWLIFFRFLLGIGIGGDYPLSATIMSEYANKKRRGALIAAVFAMQGFGILAGAI----------------V 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 184 GGILPLLFAPVLIWLLPESvrflvvkrapAERIRRIMqrLYPGQIPdeaefslpaqpvqanAMRIVLSRQYRFGSMMLWL 263
Cdd:cd17364 154 TLILSAIFEHPLPAGTYHH----------ADLVWRIV--LGLGAIP---------------ALSVLYFRKHLLGTAGTWF 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 264 VYFMGLFLVYLLGSwlpTLVKEVG----LTVGQAAVMTAMYQ-----AGGTLGSLFAGWLMDRINPHRALGLIYAVGGLF 334
Cdd:cd17364 207 LLDIAFYGQNLFQS---TIISAIGfsktMNAYQELFNIAVGQliialAGTVPGYWFTVFLIDRIGRKKIQMMGFFGMTIF 283
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 335 TMAMGYA--------AASFALICLLAFISGAclnGANTGMNALSARYYPTEARATGSSWMHGVGRMGAILSAFaGAEMLA 406
Cdd:cd17364 284 LLILAGPydhwkistIGFFVLYGLTFFFSNF---GPNTTTFIVPAEVFPARVRSTCHGISAASGKIGAIVGSF-LFLSLT 359
|
410
....*....|....
gi 503994177 407 LNISFESVFLILGI 420
Cdd:cd17364 360 QNIGVRNVLIILAG 373
|
|
| xylE |
PRK10077 |
D-xylose transporter XylE; Provisional |
45-209 |
2.97e-10 |
|
D-xylose transporter XylE; Provisional
Pssm-ID: 182225 [Multi-domain] Cd Length: 479 Bit Score: 62.02 E-value: 2.97e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 45 FIAPTLKQEwGVSNHQLGFVISAALIGLALGAIFSGPLADWLGRKK-IIINSVFF-----------FGFWTIATALSQNI 112
Cdd:PRK10077 42 FVAPQNLSE-SAANSLLGFCVASALIGCIIGGALGGYCSNRFGRRDsLKIAAVLFfisalgsawpeFGFTSIGPDNTGYV 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 113 EQMMVFRFLTGLGLGAAMPNIGTLVSEYAPERQRSFLIT-----IIF----CGFTFGAAAGGFSASWLIpQFGWHsLMLL 183
Cdd:PRK10077 121 PEFVIYRIIGGIGVGLASMLSPMYIAEIAPAHIRGKLVSfnqfaIIFgqlvVYFVNYFIARSGDASWLN-TDGWR-YMFA 198
|
170 180
....*....|....*....|....*.
gi 503994177 184 GGILPLLFAPVLIWLLPESVRFLVVK 209
Cdd:PRK10077 199 SEAIPALLFLMLLYFVPETPRYLMSR 224
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
24-398 |
3.19e-10 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 61.88 E-value: 3.19e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 24 LVVFLGFCVIALDGFDI---AIMGfiaptLKQEWGVSNHQLGFVISAALIGLALGAIFSGPLADWLGRKKIIINSVFFFG 100
Cdd:cd17327 8 PLLCILYFLQYLDKSNIsnaAVMG-----MKEDLKLVGNQYNWGNTVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 101 FWTIATALSQNIEQMMVFRFLTGLGLGAAMPNIGTLVSEYAPERQRSFLITIIFCGFTFGAAAGGFSASWLI------PQ 174
Cdd:cd17327 83 LLTLLTAAVKNFGGLIALRFFLGLFESGVFPGFILYLGMWYKREEQAKRIAFFYAAAGLGSIFGGLLAYGVFkilgvgGL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 175 FGWHSLMLLGGILPLLFAPVLIWLLP---ESVRFL-------VVKRAPAERIRRIMQRLYPGQIPDeaefslpaqpvqan 244
Cdd:cd17327 163 AGWRWLFIIEGLITIIIGLVIFFWLPdnpSKAWFLteeekelAVERLRANQTGKGDQKFKWKQIKE-------------- 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 245 AMRIVlsrqyrfgSMMLWLVYFMGLFLV-YLLGSWLPTLVKEVGLTVGQAAVMTAMYQAGGTLGSLFAGWLMDRINpHRA 323
Cdd:cd17327 229 AFKDP--------RTWLLFLFFFCSQITnNGISNFLPLILKSLGFYSLQTNLLSVPIGALGAVSLLIAALLSDRFK-KRG 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 324 LGLIYA-----VGGLFTMAMGYAAASFALICLLAFISGACLNGANTGMNALSARYYpteARATGSSWMHGVGRMGAILSA 398
Cdd:cd17327 300 LFAIFAcvlalVGSIILLAAPNPPGAYFAAYILGGGSYAGFPILLSWISSNCAGYT---KRATVLAIMLIFYNVGNIVAP 376
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
44-400 |
3.20e-10 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 61.52 E-value: 3.20e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 44 GFIAPTLKQEWGVSNHQLGFVISAALIGLALGAIFSGPLADWLGRKKIIINSVFFFGFWTIATALSQNIEQMMVFRFLTG 123
Cdd:cd17312 23 SVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWFFAVLWGLNG 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 124 LGLGAAMPNIGTLVSEYAPERQRSFLITIIFCGFTFGAAAGGFSASWLIPQFGWHSLMLLGGILPLLFAPVLIWLLPESV 203
Cdd:cd17312 103 LFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAFLVPGIVGLVVAIILFFFLRDSP 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 204 RFLVVkrapaerirrimqrlypgqipdeaefslpaqpvqanamrivlsrqyrfgsmmLWLVYFMGLFLVYLLGSWLPTLV 283
Cdd:cd17312 183 PYVWV----------------------------------------------------LSLAYAFVYIVRYACLDWGPLYL 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 284 KEV-GLTVGQAAVMTAMYQAGGTLGSLFAGWLMDRINPHR--ALGLIYAVGGLFTMA-MGYAAASFALICLLAFISGACL 359
Cdd:cd17312 211 YEVkGYSLIDAGWFSSLYEVGGIAGTILAGLLSDKLFGGRraPIAVIYMLLMTLSLAlFWFFPHNKLLSIVLLFLIGFFV 290
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 503994177 360 NG-ANTGMNALSARYYPTEARATGSSWMHGVGRMGAILSAFA 400
Cdd:cd17312 291 GGpINLIGGAAAQDIGRKEAAGTATGFVGLFGYLGASLAGLP 332
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
61-427 |
3.53e-10 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 61.48 E-value: 3.53e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 61 LGFVISAALIGLALGAIFSGPLADWLGRKKIIINS-----VFFFGFWTIATALSQNIEQMMVFRFLTGLGLGAAMPNIGT 135
Cdd:cd06173 36 VGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILAdllraLLAAVLALLALLGSLSLWLLLVLAFLLGIASAFFGPARQA 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 136 LVSEYAPERQRSFLITIIFCGFTFGAAAGGFSASWLIPQFGWHSLMLLGGILPLLFAPVLIWLlpesvRFLVVKRAPAER 215
Cdd:cd06173 116 LLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALSFLLSALLLLFI-----RRPPPAAPGESS 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 216 IRRIMQRLypgqipdeaefslpaqpvqaNAMRIVLSRQYRFGSMMLWLVYFMGLFLVYLLgswLPTLVKEV-GLTVGQAA 294
Cdd:cd06173 191 SLLLRDLR--------------------EGLRYLRRSPLLRLLLLALALFALLGGALTVL---LPLLAKEVlGGGAAGYG 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 295 VMTAMYQAGGTLGSLFAGWLMDRINPHRALGLIYAVGGLFTMAMGyAAASFALICLLAFISGACLNGANTGMNALSARYY 374
Cdd:cd06173 248 LLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLG-LSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRV 326
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 503994177 375 PTEARATGSSwMHGVGRMGAILSAFAGAEMLALNISFESVFLILGIPAAITVA 427
Cdd:cd06173 327 PDELRGRVFS-VYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAAL 378
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
20-198 |
3.57e-10 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 61.48 E-value: 3.57e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 20 RFQKLVVFLGFCVIALDGFDIAIMGFIAPTLKQEWGVSNHQLGFVISAALIGLALGAIFSGPLADWLGRKKIIINSVFFF 99
Cdd:cd06173 205 RRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLL 284
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 100 GFWTIATALSQNIEQMMVFRFLTGLGLGAAMPNIGTLVSEYAPERQRSFLITIIFCGFTFGAAAGGFSASWLIPQFGWHS 179
Cdd:cd06173 285 GLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSA 364
|
170
....*....|....*....
gi 503994177 180 LMLLGGILPLLFAPVLIWL 198
Cdd:cd06173 365 VFLLAGALLLLAALLLLLL 383
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
39-387 |
4.08e-10 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 61.63 E-value: 4.08e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 39 DIAIMGFIAPTLKQEWGVSNHQLGFVISAALIGLALGAIFSGPLADWLGRKKIIINSVFFFGFWTIATALSQNIEQMMVF 118
Cdd:TIGR00711 17 DSTIVNVAIPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSLLCGVAPNLELMIIF 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 119 RFLTGLGLGAAMPNIGTLVSEYAPERQRSFLITIIFCGFTFGAAAGGFSASWLIPQFGWHsLMLLGGILPLLFAPVLIWL 198
Cdd:TIGR00711 97 RVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWR-WIFLINVPIGIIVVVVAFF 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 199 L------PESVRF----------------LVVKRAPAERIRRIMQRLYPGQIPDEAEFSLPAQPVQANA----MRIVLSR 252
Cdd:TIGR00711 176 IlprdkpAASENFdflgllllsvglgsllYGLSEGPERGWFDSNEILILSITGLVAIIAFVVWELTDDNplvdLRLFKYR 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 253 QYRFGSMMLWLVYFMGLFLVYLLGSWLPTLVKEVGLTVGQAAVMTAMYQAggtLGSLFAGWLMDRINPHRAL--GLIYAV 330
Cdd:TIGR00711 256 NFTIGCVYMSLLGLGLYGSFYLLPLYLQQVLGYTALQAGLHILPVGLAPM---LSSPIAGRMGDKIDPRKLVtiGLILYA 332
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 503994177 331 GGLFTMAMGYA-AASFALICLLAFISGACLNGANTGMNALSARYYPTEARATGSSWMH 387
Cdd:TIGR00711 333 VGFYWRAFTFTpDTPFLAIALPQFIRGFGMGCFFMPLTTIALSGLPPHKIARGSSLSN 390
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
261-429 |
1.19e-09 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 59.74 E-value: 1.19e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 261 LWLVYFMGLFLVYLLGSWLP-TLVKEVGLTVGQAAVMTAMYQAGGTLGSLFAGWLMDRINPHRALGLIYAVGGLFTMAMG 339
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPlLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 340 YAAASFALIcLLAFISGACLNGANTGMNALSARYYPTEARATGSSWMHGVGRMGAILSAFAGAeMLALNISFESVFLILG 419
Cdd:pfam07690 81 FASSLWLLL-VLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGG-LLASLFGWRAAFLILA 158
|
170
....*....|
gi 503994177 420 IPAAITVAGL 429
Cdd:pfam07690 159 ILSLLAAVLL 168
|
|
| MFS_PLT |
cd17437 |
Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The ... |
37-205 |
2.05e-09 |
|
Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The plant Polyol transporter (PLT) subfamily includes PLT1-6 from Arabidopsis thaliana and similar transporters. The best characterized member of the group is Polyol transporter 5, also called Sugar-proton symporter PLT5, which mediates the H+-symport of numerous substrates including linear polyols (such as sorbitol, xylitol, erythritol or glycerol), cyclic polyol myo-inositol, and different hexoses, pentoses (including ribose), tetroses, and sugar alcohols. It functions to transport a wide range of substrates into specific sink tissues in the plant. The PLT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340995 [Multi-domain] Cd Length: 387 Bit Score: 58.95 E-value: 2.05e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 37 GFDIAIMGFIAPTLKQEWGVSNHQLGFVISAALIGLALGAIFSGPLADWLGRKKIIINSVFFFGFWTIATALSQNIEQMM 116
Cdd:cd17437 10 GYDIGVMSGAVIFIKEDLKISDVQEEVLIGSLNIISLVGSLAAGRTSDWIGRRYTIALAALIFFVGALLMGVAPNYPVLM 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 117 VFRFLTGLGLGAAMPNIGTLVSEYAPERQRSFLITI--------IFCGFTFGAAAGGFSAswlipQFGWHsLMLLGGILP 188
Cdd:cd17437 90 VGRFVAGIGVGFALMIAPVYTAEVAPASSRGFLTSFpeifinigILLGYVSNYAFSGLPL-----HVGWR-LMLGVGAVP 163
|
170
....*....|....*..
gi 503994177 189 LLFAPVLIWLLPESVRF 205
Cdd:cd17437 164 SLFLAIGVLAMPESPRW 180
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
32-178 |
3.78e-09 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 57.96 E-value: 3.78e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 32 VIALDGFDIAIMGFIAPTLKQEWGvSNHQLGFVISAALIGLALGAIFSGPLADWLGRKKIIINSVFFFGFWTIATALSQN 111
Cdd:cd17502 4 ALFLAALDQTIVATALPTIVAEFG-GLSLVSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPN 82
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 503994177 112 IEQMMVFRFLTGLGLGAAMPNIGTLVSEYAPERQRSFLITIIFCGFTFGAAAGGFSASWLIPQFGWH 178
Cdd:cd17502 83 MTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWR 149
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
74-431 |
4.84e-09 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 57.92 E-value: 4.84e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 74 LGAIFSGPLADWLGRKKIIINSVFFFGFWTIATALSQNIEQ--------MMVFRFLTGLGLGAAMPNIGTLVSEYAPERQ 145
Cdd:cd17369 59 LGGVVFGHFGDRIGRKKTLVLTLLLMGIATFLIGLLPTYAQigilapilLVLLRLLQGLALGGEWGGAVLMAVEHAPPKR 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 146 RSFLITIIFCGFTFG--AAAGGFSA-SWLIPQfgwHSLMLLGGILPLLFAPVLI----WL---LPESVRFLVVKRAPAER 215
Cdd:cd17369 139 RGFYGSFPQLGAPVGllLATGVFLLlSALLSD---EAFLSWGWRIPFLLSAVLVavglYIrlrLEETPVFRRAKEAGQVV 215
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 216 irrimqrlypgqipdeaefSLPAQPVQANAMRIVLSRqyrFGSMMLWLVYFmGLFLVYLLgSWLpTLVKEVGLTVGQAAV 295
Cdd:cd17369 216 -------------------RAPLVEVLRRHWRALLLA---IGLRLAENVLF-YLFTTFAL-SYA-TQTLGVDRSTVLLAV 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 296 MTAMyqAGGTLGSLFAGWLMDRINPHRalglIYAVGGLFTMAMGYAA-------ASFALICLLAFISGACLNGANTGMNA 368
Cdd:cd17369 271 LIAS--VVAAITIPLFGWLSDRVGRRP----VYLAGALLAALFAFPFfwlldtgSTWLIVLAAVVVLGVLHGMMYGPQAA 344
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 503994177 369 LSARYYPTEARATGSSWMHGVGrmGAILSAFAGAEMLALNISFESVFLILGIPAAITVAGLAA 431
Cdd:cd17369 345 FLAELFPTRVRYTGASLGYQLG--AILGGGFAPLIATALVAATGSWWPVALYLAALAVISLVA 405
|
|
| MFS_KgtP |
cd17367 |
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ... |
38-415 |
1.06e-08 |
|
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 56.92 E-value: 1.06e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 38 FDIAIMGFIAPTLKQEWGVSNHQLGFVISAALIGLA------LGAIFSGPLADWLGRKKIIINSVFFFGFWTIATALSQN 111
Cdd:cd17367 13 YDWYVYAAFALYFAPQFFPSGDPTVALLSTAAVFAVgflmrpIGGWLFGRLADRIGRRAALTLSVSLMAAGSLVIAVTPT 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 112 IEQ--------MMVFRFLTGLGLGAAMPNIGTLVSEYAPERQRSFLITIIFCGFTFG---AAAGGFSASWL-----IPQF 175
Cdd:cd17367 93 YATigiwapiiLLLARLLQGLSVGGEYGTSATYLSEVAPPGRRGFYSSFQYVTLIGGqllALGVLLVLQHTlgedqMAAW 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 176 GWHSLMLLGGILPLlfapVLIWLlpesvrflvvkrapaeriRRIMqrlypgqiPDEAEFSLPAQPVQANAMRIVLSRQYR 255
Cdd:cd17367 173 GWRIPFLLGGVLAV----VVLWL------------------RRGL--------EETESFEAIAESNEASAGTLRELRRHP 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 256 FGSMMLWLVYFMGLFLVYLLGSWLPT-LVKEVGLTVGQAAVMTAMYQAGGTLGSLFAGWLMDRINPHRALgLIYAVGGLF 334
Cdd:cd17367 223 RELLLVVGLTAGGTLAFYTWTTYLQKfLVNTAGFSKGDATWITTAALLVFMLLQPLGGRLSDRIGRRPLL-LFFGIGGTL 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 335 TMAMGYAAAS--------FALICLlafisGACLNGANTGMNAL-SARYYPTEARATGSSWMHGVGrmgaiLSAFAG-AEM 404
Cdd:cd17367 302 ATVPLLSALDhtdspytaFALVLV-----GLVFLSGYTSINAVvKAELFPTHVRALGVGLPYALA-----VAIFGGtAPY 371
|
410
....*....|....
gi 503994177 405 LAL---NISFESVF 415
Cdd:cd17367 372 VALwlkSIGHEWVF 385
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
62-197 |
3.21e-08 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 55.35 E-value: 3.21e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 62 GFVISAALIGLALGAIFSGPLADWLGRKKIIINSVFFFGFWTIATALSQNIEQMMVFRFLTGLGLGAAMPNIGTLVSEYA 141
Cdd:cd17391 243 GLVFSATGVSSLLSAPRLGKLGDRIGHHRILLGALLASALLYIPQAFVQTPWQLGILRFLLGLATGGLLPAINSLLAKIT 322
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 142 PE----RQRSFLITIIFCGFTFGAAAGGFSASWlipqFGWHSLMLLGGILpLLFAPVLIW 197
Cdd:cd17391 323 PKevagRIFGYNQSFQYLGNVAGPLLGSAIAAH----FGYRAVFVVTALL-VLLNAIWSF 377
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
41-215 |
3.25e-08 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 55.31 E-value: 3.25e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 41 AIMGFIAPTLKQEWGVSNHQLGFVISAALIGLALGAIFSGPLADWLGRKKIIINSVFFFGFWTIATALSQNIEQMMVFRF 120
Cdd:cd17329 17 MVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALV 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 121 LTGLGLGAAMPNIGTLVSEYAPERQRSFLITIIFCGFTFGAAAGGFSASWLIpQFGWHSLMLLGGILPLLFAPVLIWLLP 200
Cdd:cd17329 97 LTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLL-LYSFRLLFLAAAVLFLLAALVLLFLLP 175
|
170
....*....|....*
gi 503994177 201 ESVRFLVVKRAPAER 215
Cdd:cd17329 176 ETRPKRRAAEKTEIL 190
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
62-199 |
3.31e-08 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 55.29 E-value: 3.31e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 62 GFVISAALIGLALGAIFSGPLADWLGRKKIIINSVFFFGFWTIATALSQNIEQMMVFRFLTGLGLGAAMPNIGTLVSEYA 141
Cdd:cd17489 230 GLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLV 309
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 503994177 142 PERQRSFLITIIFCGFTFGAAAGGFSASWLIPQFGWHSLMLLGGILPLLFAPVLIWLL 199
Cdd:cd17489 310 PPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVLYIFLL 367
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
46-395 |
7.95e-08 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 54.18 E-value: 7.95e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 46 IAPTLKQEWGVSNHQLGFVISAALIGLALGAIFSGPLAD-WLGRKKIIINSVFFFGFWTIATALSQNIEQMMVFRFLTGL 124
Cdd:cd17341 21 LGPVIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDrFGGRRVFIASLLLLLIPLLALALAVSSYWGLLVLGFLLGF 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 125 GLG---AAMPNIGTLvseYAPERQRSFLiTIIFCGFTFGAAAGGFSASWLI-------PQFGWHSLMLLGGILPLLFApV 194
Cdd:cd17341 101 AGAnfaSGQPWASFW---FPKEKIGGAA-GGIAGAGNMGVAVSQLLAPLIAgaivfdgGFVGWRNAFFVPGILLAIAA-V 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 195 LIWLLpesvrflvvkrapaerirriMQRLypgqiPDEAEFSLPAQPVQANAmrivlSRQYRFGSMMLWLVYFMGLFLVYl 274
Cdd:cd17341 176 LVLLF--------------------GDDL-----PTGKASALEFLKVQLAV-----LKNYRTWILSLLYGVTFGSFVGF- 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 275 lGSWLPTLVKEV-GLTVGQAAVMTAMYQAGGTLGSLFAGWLMDRINPHRALGLIYAVGGLFTMAMGYAAASFALICLLAF 353
Cdd:cd17341 225 -SNVLPTYFKTRfGLPLVTAGILAALFPLAGALARPAGGWLSDRFGGRRRLWWLFIVMTIGAALLSLSLPTSGTNLVLFL 303
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 503994177 354 ISGACLNGANTGMNALSARYYPTEARATGSSWMHGVGRMGAI 395
Cdd:cd17341 304 ALFVALGLGAGAGNGSVFRMVPFIFRRELGAVTGLVGAIGGL 345
|
|
| PRK15402 |
PRK15402 |
MdfA family multidrug efflux MFS transporter; |
66-127 |
1.42e-07 |
|
MdfA family multidrug efflux MFS transporter;
Pssm-ID: 185300 [Multi-domain] Cd Length: 406 Bit Score: 53.40 E-value: 1.42e-07
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 503994177 66 SAALIGLALGAIFSGPLADWLGRKKIIINSVFFFGFWTIATALSQNIEQMMVFRFLTGLGLG 127
Cdd:PRK15402 55 TAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVAFFILTCLAILLAQSIEQFTLLRFLQGIGLC 116
|
|
| MFS_SLC22A6_OAT1_like |
cd17446 |
Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar ... |
66-160 |
1.44e-07 |
|
Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar transporters of the Major Facilitator Superfamily; This subfamily includes solute carrier family 22 member 6 (SLC22A6, also called organic anion transporter 1 or OAT1 or para-aminohippurate (PAH) transporter), SLC22A8 (or OAT3), and SLC22A20 (or OAT6). OAT1 and OAT3 are involved in the renal elimination of endogenous and exogenous organic anions (OAs). They function as OA exchangers, coupling the uptake of OAs against an electrochemical gradient with the efflux of intracellular dicarboxylates. SLC22A20 is an OA transporter that mediates the uptake of estrone sulfate. The OAT1-like subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341004 [Multi-domain] Cd Length: 339 Bit Score: 53.19 E-value: 1.44e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 66 SAALIGLALGAIFSGPLADWLGRKKIIINSVFFFGFWTIATALSQNIEQMMVFRFLTGLGLGAAMPNIGTLVSEYAPERQ 145
Cdd:cd17446 40 SIYMAGVLVGAIVFGGLSDRFGRRPLLIWSYLQMAVSGTCAAFSPSFPIYCVFRFLTGMALSGIVLNSVSLNVEWMPTRV 119
|
90
....*....|....*
gi 503994177 146 RSFLITIIFCGFTFG 160
Cdd:cd17446 120 RAVVGTLLGYCYTLG 134
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
261-427 |
6.04e-07 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 51.42 E-value: 6.04e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 261 LWLVYFMGLFLVYLLGSWLPTLVKEVGLTVGQAAVMTAMYQAGGTLGSLFAGWLMDRINPHRALGLIYAVGGLFTMAMGY 340
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 341 aAASFALICLLAFISGACLNGANTGMNALSARYYPTEARATGSSWMHGVGRMGAILSAFAGAEMLALnISFESVFLILGI 420
Cdd:cd17325 81 -ATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADA-LGYRAPFLVCAA 158
|
....*..
gi 503994177 421 PAAITVA 427
Cdd:cd17325 159 LALLALV 165
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
46-170 |
9.76e-07 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 50.72 E-value: 9.76e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 46 IAPTLKQEWGVSNHQLGFVISAALIGLALGAIFSGPLADWLGRKKIIINSVFFFGFWTIATALSQNIEQMMVFRFLTGLG 125
Cdd:cd17476 20 ILPIIGDSFGTSPNQLSWLAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWSLIAGFSPNFIFFIICRALQGLG 99
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 503994177 126 LGAAMPN-IGTLVSEYAPERQRSFLITIIFC----GFTFGAAAGGFSASW 170
Cdd:cd17476 100 PAFLLPNaMALLGRTYPPGPRKNIVFSLFGAtaplGFALGGVFGGLFAQL 149
|
|
| MFS_SLC22A1_2_3 |
cd17379 |
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, ... |
70-160 |
1.21e-06 |
|
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, and 3) of the Major Facilitator Superfamily of transporters; This sufamily includes solute carrier family 22 member 1 (SLC22A1, also called organic cation transporter 1 or OCT1), SLC22A2 (or OCT2), SLC22A3 (or OCT3), and similar proteins. OCT1-3 have similar basic functional properties: they are able to translocate a variety of structurally different organic cations in both directions across the plasma membrane; to translocate organic cations independently from sodium, chloride or proton gradients; and to function as electrogenic uniporters for cations or as electroneutral cation exchangers. They show overlapping but distinct substrate and inhibitor specificities, and different tissue expression pattern. In humans, OCT1 is strongly expressed in the liver, OCT2 is highly expressed in the kidney where it is localized at the basolateral membrane of renal proximal tubules, and OCT3 is most strongly expressed in skeletal muscle. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. The SLC22A1-3 subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340937 [Multi-domain] Cd Length: 340 Bit Score: 50.43 E-value: 1.21e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 70 IGLALGAIFSGPLADWLGRKKIIINSVFFFGFWTIATALSQNIEQMMVFRFLTGLGLGAAMPNIGTLVSEYAPERQRSFL 149
Cdd:cd17379 44 LGFLIGSIVIGYLADRFGRKVCFLISILGNGVSGVLMAFSPNYPWFLIFRFLQGLFGKGGWMTGYVLVTEFVGSKYRRTV 123
|
90
....*....|.
gi 503994177 150 ITIIFCGFTFG 160
Cdd:cd17379 124 GIVYQMFFTLG 134
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
261-427 |
1.45e-06 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 50.12 E-value: 1.45e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 261 LWLVYFMGLFLVYLLGSWLPTLVKEVGLTVGQAAVMTAMYQAGGTLGSLFAGWLMDRINPHRALGLIYAVGGLFTMAMGy 340
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFA- 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 341 AAASFALICLLAFISGACLNGANTGMNALSARYYPTEARATGSSWMHGVGRMGAILSAFAGAEM-LALNISFESVFLILG 419
Cdd:cd06174 80 FAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILaSSLGFGWRAVFLIAA 159
|
....*...
gi 503994177 420 IPAAITVA 427
Cdd:cd06174 160 ALALLAAI 167
|
|
| PRK09874 |
PRK09874 |
multidrug efflux MFS transporter MdtG; |
17-417 |
1.68e-06 |
|
multidrug efflux MFS transporter MdtG;
Pssm-ID: 182127 [Multi-domain] Cd Length: 408 Bit Score: 49.92 E-value: 1.68e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 17 PLSRFQKLVVFLGFCVIALDGFDIaIMGFIaPTLKQEWGVSNHQL-----GFVISAALIGLALGAIFSGPLADWLGRKKI 91
Cdd:PRK09874 9 PINWKRNLTVAWLGCFLTGAAFSL-VMPFL-PLYVEQLGVTGHSAlnmwsGLVFSITFLFSAIASPFWGGLADRKGRKIM 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 92 IINSVFFFGFWTIATALSQNIEQMMVFRFLTGLgLGAAMPNIGTLVSEYAPERQRSFLITIIFCGFTFGAAAGGFSASWL 171
Cdd:PRK09874 87 LLRSALGMGIVMVLMGLAQNIWQFLILRALLGL-LGGFVPNANALIATQVPRNKSGWALGTLSTGGVSGALLGPLAGGLL 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 172 IPQFGWHSLMLLGGilPLLFAPVLIWLLPESVRFLVVKRAPAERIRRIMQRLypgqipdeaefslpaqpvqaNAMRIVLS 251
Cdd:PRK09874 166 ADSYGLRPVFFITA--SVLFLCFLVTLFCIRENFQPVSKKEMLHMREVVTSL--------------------KNPKLVLS 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 252 rqyrfgsmmlwlVYFMGLFLVYLLGSWLPTL---VKEVGLTVGQAAVMTAMYQAGGTLGSLFA----GWLMDRINPHRAL 324
Cdd:PRK09874 224 ------------LFVTTLIIQVATGSIAPILtlyVRELAGNVSNIAFISGMIASVPGVAALLSaprlGKLGDRIGPEKIL 291
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 325 GLIYAVGGLFTMAMGYAAASFALiCLLAFISGACLNGANTGMNALSARYYPTEARATGSSWMHGVGRMGAILSAFAGAEM 404
Cdd:PRK09874 292 ITALIFSVLLLIPMSFVQTPLQL-GILRFLLGAADGALLPAVQTLLVYNSSNQIAGRIFSYNQSFRDIGNVTGPLMGAAI 370
|
410
....*....|...
gi 503994177 405 LAlNISFESVFLI 417
Cdd:PRK09874 371 SA-NYGFRAVFLV 382
|
|
| MFS_SLC22A17_like |
cd17373 |
Solute carrier family 22, member 17 and similar proteins of the Major Facilitator Superfamily; ... |
69-333 |
2.86e-06 |
|
Solute carrier family 22, member 17 and similar proteins of the Major Facilitator Superfamily; This group is composed of Solute carrier family 22, members 17, 23, and 31. They are members of the SLC22 family of organic cation/anion/zwitterion transporters, which includes organic cation transporters (OCTs/OCTNs) and organic anion transporters (OATs). SLC22A17 functions as a cell surface receptor for lipocalin-2 (LCN2), also called NGAL or 24p3, which plays a key role in iron homeostasis and transport. SLC22A23 and SLC22A31 are orphan members of the SLC22 family. SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22A17-like group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340931 [Multi-domain] Cd Length: 348 Bit Score: 49.05 E-value: 2.86e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 69 LIGLALGAIFSGPLADWLGRKKIIINSVFFFGFWTIATALSQNIEQMMVFRFLTGLGLGAAMPNIGTLVSEYAPERQRsf 148
Cdd:cd17373 35 LLGLIFGYLILGCIADRFGRRPVLLFSLILILIFGLTVALAVSVTMFSTLRFLEGFCLAGIILTLYLLRLELCDPGKR-- 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 149 litiifCGFTFGAAAGGFSASWLIPQFG-----WHSLMLLgGILPLLFAPVLIWLLPESVRFLVVKRAPAERIRRIMQRL 223
Cdd:cd17373 113 ------LMITMVASLVAVAGQFLMPGLAalcrdWRVLQAL-IICPFLLMLLYWSIFPKNILILGFNSLTGYGIRHCFARS 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 224 YPGQIPDeaEFSLPA------QPVQANAMRIVLSRQYRFGSMMLW-----LVYFMGLFLVYLLGSWLPTLVKEVGLTVGQ 292
Cdd:cd17373 186 MMGHEPE--NFYLDYyltagiAAVACVFLCVTVDFLGRRGGLLLFmiltgLASLLLLGLLNLIGKYSQHPDSGMSDSVKD 263
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 503994177 293 AAVMTAMY------QAGGTLGSLFAGWLMDRINPHRALGLIYAVGGL 333
Cdd:cd17373 264 KFSIAFSVlglfasHAVGSLSVLFAAEVTPTVIRGGGLGLVLASGGL 310
|
|
| uhpT |
PRK09556 |
hexose-6-phosphate:phosphate antiporter; |
24-361 |
3.19e-06 |
|
hexose-6-phosphate:phosphate antiporter;
Pssm-ID: 236564 [Multi-domain] Cd Length: 467 Bit Score: 49.28 E-value: 3.19e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 24 LVVFLGFCVIAL--DGFDIAimgfiAPTLKQEWGVSNHQLGFVISAALIGLALGAIFSGPLADWLGRKKI-----IINSV 96
Cdd:PRK09556 32 LVVFIGYLTMYLirKNFKAA-----QNDMISTYGLSTTELGMIGLGFSITYGVGKTLVGYYADGKNTKQFlpfllILSAI 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 97 FFFGFWTIATALSQNIEQMMVFRFLTGLGLGAAMPNIGTLVSEYAPERQRSFLITIIFCGFTFGAAAGGFSASWlipqfG 176
Cdd:PRK09556 107 CMLGFGASLGSGSVSLGLMIALWALSGFFQSTGGPCSYSTITRWTPRRKRGRFLGFWNISHNLGGAGAGGVALW-----G 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 177 WHSLmLLGGILPLLFAPVLIWLLPESVRFLVVKRAPAERirrimqrlypGQIPDEAEFSLPAQPVQANAMRIVLSR---- 252
Cdd:PRK09556 182 ANYF-FDGHVIGMFIFPSIIALIIGFIGLRYGSDSPEEL----------GWGKAEEIFGEPISEEDKETESTDMTKwqif 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 253 -QYRFGSMMLWLVYFMGLFL-VYLLG--SWLPTLVK-EVGLTVGQAAVMTAMYQAGGTLGSLFAGWLMDRINPHRALGLI 327
Cdd:PRK09556 251 vEYVLKNPVIWLLCFANIFLyIVRIGidNWSPVYAFqELGFSKEDAINTFTLFEIGALVGSLLWGWLSDLANGRRALVAC 330
|
330 340 350
....*....|....*....|....*....|....*
gi 503994177 328 YAVGGLFTMAMGYAAASFALICLLA-FISGACLNG 361
Cdd:PRK09556 331 IALALIIFTLGVYQHATSEYMYLASlFALGFLVFG 365
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
30-208 |
3.86e-06 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 48.73 E-value: 3.86e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 30 FCVIALDGFDIAIMGFIAPTLKQEW---GVSNHQLGFVISAALIGLALGAIFSGPLADWLGRKKIIINSVFFFGFWTIAT 106
Cdd:cd17330 2 FLVVFLDALGFGIVFPVLPFYVREFnklGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 107 ALSQNIEQMMVFRFLTGLgLGAAMPNIGTLVSEYAPERQRSFLITIIFCGFTFGAAAGGFSASWLIPQFGWHSLMLLGGI 186
Cdd:cd17330 82 GLSRNLWLLFLARFLDGL-TGGNVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAA 160
|
170 180
....*....|....*....|..
gi 503994177 187 LPLLFAPVLIWLLPESVRFLVV 208
Cdd:cd17330 161 LALLNLVLVLFFLPPLRRLLLV 182
|
|
| MFS_GLUT8_Class3 |
cd17433 |
Glucose transporter type 8, a Class 3 GLUT, of the Major Facilitator Superfamily of ... |
56-207 |
3.90e-06 |
|
Glucose transporter type 8, a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 8 (GLUT8) is also called Solute carrier family 2, facilitated glucose transporter member 8 (SLC2A8) or glucose transporter type X1 (GLUTX1). It is classified as a Class 3 GLUT protein and is an insulin-regulated facilitative glucose transporter predominantly expressed in testis and brain. It can also transport fructose and galactose. SLC2A8 knockout mice were viable, developed normally, and display only a very mild phenotype, including mild alterations in the brain (increased proliferation of hippocampal neurons), heart (impaired transmission of electrical wave through the atrium), and sperm cells (reduced number of motile sperm cells). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340991 [Multi-domain] Cd Length: 416 Bit Score: 49.10 E-value: 3.90e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 56 VSNHQLGFVISAALIGLALGAIFSGPLADWLGRK-KIIINSV-FFFGFWTIATAlsQNIEQMMVFRFLTGLGLGAAMPNI 133
Cdd:cd17433 38 LDDAAASWFGSVVTLGAAAGGVLGGWIVDRAGRKlSLMLCSVpFIAGFTVITAA--QNVWMLYVGRLLTGLASGVTSLVV 115
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 503994177 134 GTLVSEYAPERQRSFLITIIFCGFTFGaAAGGFSASWLipqFGWHSLMLLGGILPLLFApVLIWLLPESVRFLV 207
Cdd:cd17433 116 PVYISEIAHPRVRGTLGSCVQLMVVIG-IMGAYLAGLV---LDWRWLAVLGSIPPTLML-LLMCFMPETPRFLL 184
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
50-199 |
4.17e-06 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 48.72 E-value: 4.17e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 50 LKQEWGVSNHQLGFVISAALIGLALGAIFSGPLADWLG---RKKIIINSVFFFGFWTIATALSQNIEQMMVFRFLTGLGL 126
Cdd:cd17319 206 LKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLrgaRRLVIIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGI 285
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 503994177 127 GAAMPNIGTLVSEYAPERQRSFLITIIFCGFTFGAAAGGFSASWLIPQFGWHSLMLLGGILPLLFAPVLIWLL 199
Cdd:cd17319 286 GAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATGSYTAAFLFLAAVALLAALLVLLL 358
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
24-424 |
5.03e-06 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 48.32 E-value: 5.03e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 24 LVVFLGFCVIAL-DGFDIAImGFIAPTLKQEWGVSNHQLGFVISAALIGLALGAIFSGPLADWLGRKKIIINSVFFFGFW 102
Cdd:cd17352 3 VVVFASFLVNFFtDGILNSF-GVLFVELLEEFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAALG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 103 TIATALSQNIEQMMV-FRFLTGLGLGAAMPNIGTLVSEYApERQRSFLITIIFCGFTFGAAAGGFSASWLIPQFGWH-SL 180
Cdd:cd17352 82 LLLSSFATSLWQLYLtYGVLGGLGLGLIYSPAIVIVGQYF-EKKRGLATGIAVAGSGVGTFVFPPLLRYLLDNYGWRgAL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 181 MLLGGI-LPLLFAPVLIWLLPESVrFLVvkrapaerirrimqrlypgqipdeaefslpaqpvqanamrivlsrqYRFGSM 259
Cdd:cd17352 161 LILGGLcLNLCVCGLLLRLLKDPT-FVL----------------------------------------------LALGVS 193
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 260 MLWLVYFMGLFLvyllgswLPTLVKEVGLTVGQAAVMTAMYQAGGTLGSLFAGWLMDRINPHRALGLIYAVGGLFT-MAM 338
Cdd:cd17352 194 FAMLGFFVPFVY-------LPSYAKSLGIDESDAAFLLSIIGISDIVGRILLGLLADKPRIGRLYLYIFTLLILGLsLLA 266
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 339 GYAAASFALICLLAFISGACLNGANTGMNALSARYYPTEARATGSSWMHGVGRMGAILSAFAGAEMLALNISFESVFLIL 418
Cdd:cd17352 267 FPLATTYVGLIVFSVLFGFCSGSYSSLTPVILADLVGLEKLSNAYGLVLLFQGLAALVGPPIAGLLRDYTGDYDAAFYFC 346
|
....*.
gi 503994177 419 GIPAAI 424
Cdd:cd17352 347 GACLLL 352
|
|
| MFS_SLC18A1_2_VAT1_2 |
cd17384 |
Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major ... |
60-198 |
6.33e-06 |
|
Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major Facilitator Superfamily; Vesicular amine transporter 1 (VAT1 or VMAT1) is also called solute carrier family 18 member 1 (SLC18A1) or chromaffin granule amine transporter, while VAT2 (or VMAT2) is also called SLC18A2, synaptic vesicular amine transporter, or monoamine transporter. VATs (or VMATs) are responsible for the uptake of cytosolic monoamines into synaptic vesicles in monoaminergic neurons. VAT1 and VAT2 distinct pharmacological properties and tissue distributions. VAT1 is preferentially expressed in neuroendocrine cells and endocrine cells, where it transports biogenic monoamines, such as serotonin, from the cytoplasm into the secretory vesicles. VAT2 is primarily expressed in the CNS and is involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. VATs belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340942 [Multi-domain] Cd Length: 373 Bit Score: 47.95 E-value: 6.33e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 60 QLGFVISAALIGLALGAIFSGPLADWLGRKKIIINSVFFFGFWTIATALSQNIEQMMVFRFLTGLGLG----AAMPNIGT 135
Cdd:cd17384 231 QLGTAFLPDSIGYLIGTNLFGPLAHKIGRWLCSLLGMLLVGISLILIPLAKNIYGLIIPHFGLGLGIGmvdsSMMPLLAY 310
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 503994177 136 LV---------SEYAperqrsfLITIIFC-GFTFGAAAGGFsaswLIPQFGWHSLMLLGGILPLLFAPVLIWL 198
Cdd:cd17384 311 LVdlrhssvygSVYA-------IADVAFClAFALGPSLGGA----IVKSIGFPWLMRIIGIINILYAPLLFFL 372
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
17-164 |
9.19e-06 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 47.41 E-value: 9.19e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 17 PLSRFQKLVVFLGFCVIALDGFDIAIMGFIAPTLKQEWGVSNHQLGFVISAALIGLALGAIFSGPLADWLGRKKIIINSV 96
Cdd:pfam07690 193 AWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLAL 272
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 503994177 97 FFFGFWTIATALSQNIEQMMVFR---FLTGLGLGAAMPNIGTLVSEYAPERQRSFLITIIFCGFTFGAAAG 164
Cdd:pfam07690 273 LLLILAALGLLLLSLTLSSLWLLlalLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALG 343
|
|
| MFS_SLC22A23 |
cd17444 |
Solute carrier family 22, member 23 of the Major Facilitator Superfamily; Solute carrier ... |
69-208 |
1.01e-05 |
|
Solute carrier family 22, member 23 of the Major Facilitator Superfamily; Solute carrier family 22, member 23 (SLC22A23) is an orphan member of the SLC22 family of organic cation/anion/zwitterion transporters, which includes organic cation transporters (OCTs/OCTNs) and organic anion transporters (OATs). It is abundantly expressed in brain and is also found in liver. Single-nucleotide polymorphisms in SLC22A23 are associated with inflammatory bowel disease (IBD) in a Canadian white population. SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A23 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341002 [Multi-domain] Cd Length: 364 Bit Score: 47.54 E-value: 1.01e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 69 LIGLALGAIFSGPLADWLGRKKIIINSVFFFGFWTIATALSQNIEQMMVFRFLTGLGLGAAMPNIGTLVSEYAPERQRsF 148
Cdd:cd17444 46 LVGLIFGYLITGCLADWFGRRPVLLFSVVFILIFGLTVALSVNVTMFSTLRFFEGFCLAGIILSLYALRIELCPPGHR-F 124
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 503994177 149 LITIIfcgFTFGAAAGGFsaswLIPQFG-----WHSLMLLgGILPLLFAPVLIWLLPESVRFLVV 208
Cdd:cd17444 125 MITMV---ASFIAMAGQF----LMPGLAalcrdWQVLQAV-IICPFLLMLSYWCIFPKNIVVLCV 181
|
|
| 2A0109 |
TIGR00887 |
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the ... |
31-168 |
1.09e-05 |
|
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the major facilitator superfamily (pfam00083). [Transport and binding proteins, Anions]
Pssm-ID: 129965 [Multi-domain] Cd Length: 502 Bit Score: 47.80 E-value: 1.09e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 31 CVIA-----LDGFDIAIMGFIAPTLKQ-EWGVSNHQL----GFVISAALIGLALGAIFSGPLADWLGRKKIIINSVFFFG 100
Cdd:TIGR00887 18 IVIAgvgffTDSYDLFCISLVTKMLGYvYYHGKGPLPssvsAAVNGSASIGTLAGQLFFGWLADKLGRKRVYGMELIIMI 97
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 503994177 101 FWTIATAL---SQNIEQMMV---FRFLTGLGLGAAMPNIGTLVSEYAPERQRSFLITIIFCGFTFGAAAGGFSA 168
Cdd:TIGR00887 98 IATVASGLspgSSPKSVMATlcfWRFWLGVGIGGDYPLSAIITSEFATKKWRGAMMAAVFAMQGFGILAGAIVA 171
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
52-417 |
1.13e-05 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 47.26 E-value: 1.13e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 52 QEWGVSNHQL-----GFVISAALIGLALGAIFSGPLADWLGRKKIIINSVFFFGFWTIATALSQNIEQMMVFRFLTGLgL 126
Cdd:cd17391 24 EQLGVTSGGLvelwsGLAFSSTFLVSAIFSPIWGRLADRYGRKPMLLRASLGMAIVIGLMAFVTNVWQLLILRLLQGV-F 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 127 GAAMPNIGTLVSEYAPERQRSFLITIIFCGFTFGAAAGGFSASWLIPQFGWHSLMLLGGIlpLLFAPVLIWLlpesvrFL 206
Cdd:cd17391 103 SGYVPNATALIASQTPKEKSGWALGTLSTGVVAGTLIGPLLGGFLADLFGIRNVFFITGG--LLFLAFLLTL------FF 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 207 VVKrapaerirrimqrlypgqipdeaEFSLPAQPVQANAMRIVLSRQYRFGSMMLWLVYFMGLFLVYLLGSWLPTLVKEV 286
Cdd:cd17391 175 VKE-----------------------DFKPVEKKKMVSTKEVWNSVPNPSLLISLFVTTFIIQLANQSIEPILTLYIRQL 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 287 GLTVGQAAVMTAMYQAGGTLGSLFA----GWLMDRINPHRALGLIYAVGGLFTMAMGYAAASFALIcLLAFISGACLNGA 362
Cdd:cd17391 232 MGDASNLAFISGLVFSATGVSSLLSaprlGKLGDRIGHHRILLGALLASALLYIPQAFVQTPWQLG-ILRFLLGLATGGL 310
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 503994177 363 NTGMNALSARYYPTEARATGSSWMHGVGRMGAILSAFAGAeMLALNISFESVFLI 417
Cdd:cd17391 311 LPAINSLLAKITPKEVAGRIFGYNQSFQYLGNVAGPLLGS-AIAAHFGYRAVFVV 364
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
41-199 |
1.30e-05 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 47.18 E-value: 1.30e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 41 AIMGFIAPTLKQEWGVSNHQLGFVISAALIGLALGAIFSGPLADWLGRKKIIINSVFFFGFWTIATALSQNIEQMMVFRF 120
Cdd:cd17473 215 VIPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAI 294
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 121 LTGLGLGAAMPNIGTLVSEYAPERQRSFLITIIFCGFTFGAAAGGFSASWLIPQFGWHSLMLLG-GILPLLFAPVLIWLL 199
Cdd:cd17473 295 LAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLVNLTGGLSGAFLIlGVLALVLAIVLLLLR 374
|
|
| MFS_4 |
pfam06779 |
Uncharacterized MFS-type transporter YbfB; This family represents putative bacterial membrane ... |
46-201 |
1.65e-05 |
|
Uncharacterized MFS-type transporter YbfB; This family represents putative bacterial membrane proteins which may be sugar transporters. Members carry twelve transmembrane regions which are characteriztic of members of the major facilitator sugar-transporter superfamily.
Pssm-ID: 399632 [Multi-domain] Cd Length: 365 Bit Score: 46.98 E-value: 1.65e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 46 IAPTLKQEWGVSNHQLGFVISAALIGLALGAIF--SGPLADWLGRKKIIINSVFFFGFWTIATALSQNIEQMMVFRFLTG 123
Cdd:pfam06779 15 ILPVMIAEGQFSLSQAGLLAAANYAGYLAGALLasFAWRHGASRLRPALLAGLLATVLLLLAMAATSSFWAVLLIRFLAG 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 124 LGLGAAMPNIGTLVSEYAPERQRSFLITIIFCGFTFGAAAGGFSAsWLIPQFGWH--SLMLLGGILPLLFAPVLIWLLPE 201
Cdd:pfam06779 95 VASAAVMIFGSSLILGHATAARRAFVGALLFAGVGIGIALSGLLV-PLGLQLGLGgsSLWYGAGVLSAVLTLAVFPLLPR 173
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
261-427 |
1.70e-05 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 46.82 E-value: 1.70e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 261 LWLVYFMGLFLVYLLGSWLPTLVKEVGLTVGQAAVMTAMYQAGGTLGSLFAGWLMDRINPHRALGLIYAVGGLFTMAMGY 340
Cdd:cd17489 1 ILLANFFFFLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 341 aAASFALICLLAFISGACLNGANTGMNALSARYYPTEARATGSSWMHGVGRMGAILSAFAGAEMLALNiSFESVFLILGI 420
Cdd:cd17489 81 -ATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHL-GFAVLFIVAAV 158
|
....*..
gi 503994177 421 PAAITVA 427
Cdd:cd17489 159 LALLALL 165
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
46-353 |
1.70e-05 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 46.91 E-value: 1.70e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 46 IAPTLKQEWGVSNHQLGFVISAALIGLALGAIFSGPLADWLGRKKIIINSVFFFGFWTIATALSQNIEQMMVFRFLTGLG 125
Cdd:cd06180 21 LLPLMLAELGLSYAQAGWIATANYAGYLVGALLASFLRRRGRARRLIRGGLLLTVLLLAAMALTSGFAALLALRFLAGAA 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 126 LGAAMPNIGTLVSEYAPERQRSFLITIIFCGFTFGAAAGGFSASwLIPQFGWHS--LMLLGGILPLLFAPVLIWLLPESV 203
Cdd:cd06180 101 SAFVFVFGSNLVLHHATAAGRGHLIGLLFAGVGLGIALSGLLVP-AGLGGGLSWraGWLALALLSAVLLLLSFLLLRRGP 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 204 RFLVVKRAPAERIRRIMqrlypgqipdeaefslpaqpvqanamrivlsrqyrfGSMMLWLVYFMGLFLVYLLGSWLPTLV 283
Cdd:cd06180 180 SAPTEASAAESAPGLNR------------------------------------PLWRLALAYGLFGFGYIITATFLPLIA 223
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 503994177 284 KEVGLTVGQAAVMTAMYQAGGTLGSLFAGWLMDRINPHRALGLIYAVGGL-FTMAMGYAAASFALICLLAF 353
Cdd:cd06180 224 RETGAGSLLAGLLWSLFGLAAVPSCFLWGALSDRWGTRRALAANLLVQAVgVLLPLLSPGPAGLVLSAVLF 294
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
42-222 |
2.06e-05 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 46.82 E-value: 2.06e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 42 IMGFIAPTLKQEWGVSNHQLGFVISAALIGLALGAIFSGPLADWLGRKKIIINSVFFFGFWTIATALSQ--NIEQMMVFR 119
Cdd:COG2211 247 VAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGpgNLWLLLVLA 326
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 120 FLTGLGLGAAMPNIGTLVSEYAPERQRSFLIT---IIFCGFTF----GAAAGGFSASWLIPQFGWHS-----------LM 181
Cdd:COG2211 327 ALAGIGLGAILVLPWAMLADVVDYDEWKTGRRregLYFGIFTFaiklGQALAGALAGLLLALFGYVAgaaqspsaltgIR 406
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 503994177 182 LLGGILPLLFAPVLIWLLpesVRFLVVKRAPAERIRRIMQR 222
Cdd:COG2211 407 LLFFLLPAVLLLLAALLL---LFYPLTRERHAEIRAELAAR 444
|
|
| MFS_GLUT12_Class3 |
cd17435 |
Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of ... |
35-209 |
3.04e-05 |
|
Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 12 (GLUT12) is also called Solute carrier family 2, facilitated glucose transporter member 12 (SLC2A12). It is a facilitative glucose transporter, classified as a Class 3 GLUT, and is expressed in the heart, skeletal muscle, prostate, and small intestine, and is highly upregulated in breast ductal cell carcinoma. It plays a role as a secondary insulin-sensitive glucose transporter in insulin-dependent tissues. The GLUT12 subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340993 [Multi-domain] Cd Length: 376 Bit Score: 45.94 E-value: 3.04e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 35 LDGFDIAIMGFIAPTLKQEWGVSNHQLGFVISAALIGLALGAIFSGPLADWLGRKKIIINSVFFFGFWTIATALSQNIEQ 114
Cdd:cd17435 12 LVGYELGIISGALLQLRTLLALSCHEQEMVVSSLLIGALLASLTGGVLIDRYGRRTAIILTSCLLVLGSLLLVCSVSYTV 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 115 MMVFRFLTGLGLGAAMPNIGTLVSEYAPERQRSFLITI----IFCGFTFgaaagGFSASWLIPQF--GWhSLMLLGGILP 188
Cdd:cd17435 92 LIVGRIAIGVSISLSSIATCVYIAEIAPQHRRGLLVSLnelmIVIGILL-----AYISNYAFANVsnGW-KYMFGLVIPL 165
|
170 180
....*....|....*....|.
gi 503994177 189 LLFAPVLIWLLPESVRFLVVK 209
Cdd:cd17435 166 AALQAIAMYFLPPSPRFLVMK 186
|
|
| MFS_NIMT_CynX_like |
cd17339 |
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator ... |
40-357 |
3.32e-05 |
|
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli 2-nitroimidazole transporter (NIMT) and cyanate transport protein CynX, and similar proteins. NIMT, also called YeaN, confers resistance to 2-nitroimidazole, the antibacterial and antifungal antibiotic, by mediating the active efflux of this compound. CynX is part of an active transport system that transports exogenous cyanate into E. coli cells. The NIMT/CynX-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340897 [Multi-domain] Cd Length: 374 Bit Score: 46.03 E-value: 3.32e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 40 IAIMGFIAPTLKQEWGVSNHQLGFVISAALIGLALGAIFSGPLADWLGRKKIIINSVFFFgfwTIATAL--SQNIEQMMV 117
Cdd:cd17339 15 ITSVGPLLPEIRDDLGLSASQAGLLTTLPLLCFAVFSPLAPRLARRFGLERTLLLALLLL---AAGILLrsLGGIALLFL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 118 FRFLTGLGLGAAMPNIGTLVSEYAPERqRSFLITIIFCGFTFGAAAGGFSASWL--IPQFGWHSLMLLGGILPLLFApvL 195
Cdd:cd17339 92 GTALAGAGIAVGNVLLPSLIKRDFPRR-VGLMTGLYTTSMNLGAALASGLSVPLaqALGGGWRGALAIWALPALLAL--L 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 196 IWLLPESVRFLVVKRAPAERIRRIMQRlypgqipdeaefslpaqpvqanamrivlsrqyrfgSMMLWLVYFMGL--FLVY 273
Cdd:cd17339 169 IWLPQLRRRKRAAAAAAPLTKISVWRS-----------------------------------PLAWQVTLFMGLqsLLFY 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 274 LLGSWLPTLVKEVGLTVGQAAVMTAMYQAGGTLGSLFAGWLMDRINPHRALGLIYAVGGLFTMAMGYAAASFALICLLAF 353
Cdd:cd17339 214 TLMAWLPTILIDAGLSAATAGWLLSLFQLVGIPASLLVPILATRLKNQRPIVVLLAVLFIIGVLGLLFAPTALALLWAVL 293
|
....
gi 503994177 354 ISGA 357
Cdd:cd17339 294 LGLG 297
|
|
| MFS_SLC22A7_OAT2 |
cd17447 |
Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major ... |
70-200 |
3.75e-05 |
|
Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 7 (SLC22A7), also called organic anion transporter 2 (OAT2) mediates sodium-independent transport of a variety of organic anions including prostaglandin E2, prostaglandin F2, tetracycline, bumetanide, estrone sulfate, glutarate, dehydroepiandrosterone sulfate, allopurinol, 5-fluorouracil, paclitaxel, L-ascorbic acid, salicylate, ethotrexate, and alpha-ketoglutarate. It also plays a role in renal uric acid uptake from blood as a first step of tubular secretion. OAT2 belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS)of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341005 [Multi-domain] Cd Length: 341 Bit Score: 45.49 E-value: 3.75e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 70 IGLALGAIFSGPLADWLGRKKIIINSVFFFGFWTIATALSQNIEQMMVFRFLTGLGLGAAMPNIGTLVSEYAPERQRSFL 149
Cdd:cd17447 46 AGVTMGAVAFGYLSDRFGRKRMLLVAYVLSLVFGLASAFSVSYVMFAITRTLTGFALTGFSIISMVLCVEWVDIEHRTVA 125
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 503994177 150 ITIIFCGFTFGAAAGGFSAsWLIPQFGWhslMLLGGILPLLFAPVLIWLLP 200
Cdd:cd17447 126 GVLISLFWTVGNMLLALVA-YLIRDWRW---LILAVTLPCAPGIITWWWVP 172
|
|
| MFS_GLUT_Class2 |
cd17432 |
Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ... |
63-223 |
5.45e-05 |
|
Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT5, also called Solute carrier family 2, facilitated glucose transporter member 5 (SLC2A5), is a well-established fructose transporter found in the small intestine. GLUT7 (or SLC2A7) is a high-affinity glucose and fructose transporter expressed in the small intestine and colon. GLUT9 (or SLC2A9) transports urate and fructose, and is most strongly expressed in the basolateral membranes of proximal renal tubular cells, liver and placenta. It may play a role in urate reabsorption by proximal tubules. GLUT11 (or SLC2A11) is a facilitative glucose transporter expressed in heart and skeletal muscle. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340990 [Multi-domain] Cd Length: 452 Bit Score: 45.30 E-value: 5.45e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 63 FVISAALIGLALGAIFSGPLADWLGRKK-IIINSVF------FFGFWTIATALsqniEQMMVFRFLTGLGLGAAMPNIGT 135
Cdd:cd17432 54 LTVSIFPLGGLFGSLLVGPLVIRLGRKGtLLLNNIFaivaaiLMGLSKIAKSF----EMIIVGRFLVGINAGISLNVVPM 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 136 LVSEYAPERQRSFlITIIFCGFTfgaAAGGFSASWL-IPQF-----GWHSLMLLGGILPLLFAPVLIWlLPESVRFLVVK 209
Cdd:cd17432 130 YLGESAPKNLRGA-VGLVPAIFI---TLGILLGQVLgLRELlgneeGWPLLLALTGVPALLQLLTLPF-FPESPRYLLIE 204
|
170
....*....|....
gi 503994177 210 RAPAERIRRIMQRL 223
Cdd:cd17432 205 KGDEEAARKALQRL 218
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
261-420 |
5.54e-05 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 45.00 E-value: 5.54e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 261 LWLVYFMGLFLVYLLGSWLPTLVKEVGLTVGQAAVMTAMYQAGGTLGSLFAGWLMDRInPHRALGLIYAVGGLFTMAMGY 340
Cdd:cd17333 1 LYISFFSNGLTDALLGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRL-GRRRTLILGLLLISLALALIF 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 341 AAASFALICLLAFISGACLNGANTGMNALSARYYPtEARATGSSWMHGVGRMGAILSAFAGAEMLALNISFESVFLILGI 420
Cdd:cd17333 80 ATPSIYLFVVLMFLAGLGAGILDTGANTFVGALFE-ESSATRLNVLHGFFGLGALIGPLIATSLLTSELSWSWAYLIIGL 158
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
40-204 |
5.59e-05 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 45.26 E-value: 5.59e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 40 IAIMGFIAPTLKQEWGVSNHQLGFVISAALIGLALGAIFSGPLADWLGRKKIIINSVFFFGFWTIATALSQ-NIEQMMVF 118
Cdd:COG2223 222 IGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALgSLWLFLVL 301
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 119 RFLTGLGLGAAMPNIGTLVSEYAPERQRSFLITIIFCGFTFGAAAGGFSASWLIPQFGWHSLMLLGGILPLLFAPVLIWL 198
Cdd:COG2223 302 FLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAAFLVFAVLALVALVLTLL 381
|
....*.
gi 503994177 199 LPESVR 204
Cdd:COG2223 382 LYRRPR 387
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
274-454 |
6.98e-05 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 44.85 E-value: 6.98e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 274 LLGSWLPTLVKEVGLTVGQAAVMTAMYQAGGTLGSLFAGWLMDRINPHRALGLIYAVGGLFTMAMGYaAASFALICLLAF 353
Cdd:cd17478 14 FLPALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGF-APNYWLLLLLVA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 354 ISGAClNGANTGMNALSARYYPTEARATGSSWMHGVGRMGAILSAFAGAemLALNISFESVFLILGIPAAITVAGLAAKG 433
Cdd:cd17478 93 LAGIG-SAAFHPEGARLASQAAGGRRGLAMSIFSVGGNLGFALGPLIAA--ALVALFGGLGLLILLIIPGLAVALLLLRL 169
|
170 180
....*....|....*....|.
gi 503994177 434 IFAAGPTARATASTAPVRSTF 454
Cdd:cd17478 170 RPLKKPEAKKAAAKSSARSTL 190
|
|
| MFS_MosC_like |
cd17393 |
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ... |
263-451 |
7.43e-05 |
|
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340951 [Multi-domain] Cd Length: 373 Bit Score: 44.94 E-value: 7.43e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 263 LVYFMGLFLVYLLGSWLPTLVKEVGLTVGQAAVMTAMYQAGGTLGSLFAGWLMDRINPHRALGLIYAVGGLFTMAMGyAA 342
Cdd:cd17393 6 AFFFINGILMASWATRIPAIKDRLGLSDAALGLLLLALGVGALVAMPLAGRLVARFGSRRVTRLGALLLLLALLLLG-LA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 343 ASFALICLLAFISGACLNGANTGMNALSARYYPTEARATGSSwMHGVGRMGAILSAFAGAEMLALNISFESVFLILGIpA 422
Cdd:cd17393 85 PSVPALALALFLFGAANGALDVAMNAQGVAVERAYGRPIMSS-LHAMWSLGGLAGALLGAAAIGAGVSPGVHLLAAAV-L 162
|
170 180
....*....|....*....|....*....
gi 503994177 423 AITVAGLAAKGIFAAGPTARATASTAPVR 451
Cdd:cd17393 163 LLLAALVAIRALLPGTGEAAEDRPDGAGK 191
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
279-430 |
7.67e-05 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 44.85 E-value: 7.67e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 279 LPTLVKEVGLTVGQAAVMTAMYQAGGTLGSLFAGWLMDRINPHRALGLIYAVGGLFTMAMGyAAASFALICLLAFISGAC 358
Cdd:cd17324 22 LPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAA-LAPSFALLLLARALAGLA 100
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 503994177 359 LNGANTGMNALSARYYPTEARATGSSWMHGVGRMGAILSAFAGAeMLALNISFESVFLILGIPAAITVAGLA 430
Cdd:cd17324 101 HGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGG-LLGQLLGWRAAFLAIAVLALLAALLLW 171
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
262-426 |
1.55e-04 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 43.78 E-value: 1.55e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 262 WLVYFMGLFLVYLLGSWLPTLVKEVGLTVGQAAVMTAMYQAGGTLGSLFAGWLMDRINPHRALGLIYAVGGLFTMAMGYA 341
Cdd:cd17341 5 WLSFFLGFMVWFLFAPLGPVIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIPLLALALA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 342 AASFALICLLAFISGACLNGANTGMNALSaRYYPTEARATGSSWMHGVGRMGAILSAFAG------AEMLALNISFESVF 415
Cdd:cd17341 85 VSSYWGLLVLGFLLGFAGANFASGQPWAS-FWFPKEKIGGAAGGIAGAGNMGVAVSQLLApliagaIVFDGGFVGWRNAF 163
|
170
....*....|.
gi 503994177 416 LILGIPAAITV 426
Cdd:cd17341 164 FVPGILLAIAA 174
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
261-453 |
1.61e-04 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 43.77 E-value: 1.61e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 261 LWLVYFMGLFLVYLLGSWLPTLVKEVGLTVGQAAVMTAMYQAGGTLGSLFAGWLMDRINPHRALGLIYAVGGLFTMAMgY 340
Cdd:cd17475 1 ATLAQAAASLVAQGIPALAPFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLM-A 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 341 AAASFALICLLAFISGACLNGANTGMNALSARYYPTEARATGSswmhGVGRMGAILSAFAGAEML---ALNISFESVFLI 417
Cdd:cd17475 80 LVGSYPVLLVLLFLVGAGYGSVQPGGGRAIMRWFPPRERGLAM----GIRQTGVPLGGALAAALLpplALHYGWRAAFVV 155
|
170 180 190
....*....|....*....|....*....|....*.
gi 503994177 418 LGipAAITVAGLAAKGIFAAGPTARATASTAPVRST 453
Cdd:cd17475 156 AG--LVSILAAVLFWLFYREPPAASAATESASTLLR 189
|
|
| MFS_GLUT_Class1 |
cd17431 |
Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ... |
42-223 |
2.38e-04 |
|
Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-4 are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT1, also called solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1), displays broad substrate specificity and can transport a wide range of pentoses and hexoses including glucose, galactose, mannose, and glucosamine. It is found in the brain, erythrocytes, and in many fetal tissues. GLUT2 (or SLC2A2) is found in the liver, islet of Langerhans, intestine, and kidney, and is the isoform that likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by beta cells. GLUT3 (or SLC2A3) is found in the brain and can mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and dehydroascorbate. GLUT4 (or SLC2A4) is an insulin-regulated facilitative glucose transporter found in adipose tissues, and in skeletal and cardiac muscle. GLUT14 (or SLC2A14) is an orphan transporter expressed mainly in the testis. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340989 [Multi-domain] Cd Length: 445 Bit Score: 43.48 E-value: 2.38e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 42 IMGFIAPTLKQEWG--VSNHQLGFVISAAL----IGLALGAIFSGPLADWLGRKK--IIINSVFFFGFWTIATALSQNIE 113
Cdd:cd17431 27 IEEFYNKTLGDRYGepISPETLTTLWSLSVaifsVGGMIGSFSVGLFVNRFGRRNsmLYNNLLAFAGAALMGLSKLAKSY 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 114 QMMVF-RFLTGLGLGAAMPNIGTLVSEYAPERQRSFLITIIFCGFTFGAaaggfsaswLIPQ-FGWHSLMLLGGILPLLF 191
Cdd:cd17431 107 EMLILgRFIIGLYCGLTTGLVPMYIGEISPTALRGALGTLHQLGIVVGI---------LISQiFGLEFILGTEELWPLLL 177
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 503994177 192 A---------PVLIWLLPESVRFLVVKRAPAERIRRIMQRL 223
Cdd:cd17431 178 GftivpailqLALLPFCPESPRYLLINRNEEEEAKSVLKKL 218
|
|
| MFS_SLC17A6_7_8_VGluT |
cd17382 |
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of ... |
60-198 |
2.52e-04 |
|
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 17 member 6 (SLC17A6), SLC17A7, SLC17A8, and similar proteins. SLC17A6 is also called vesicular glutamate transporter 2 (VGluT2), differentiation-associated BNPI, or differentiation-associated Na(+)-dependent inorganic phosphate cotransporter. SLC17A7 is also called VGluT1 or brain-specific Na(+)-dependent inorganic phosphate cotransporter. SLC17A8 is also called VGluT3. They mediate the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells, and may also mediate the transport of inorganic phosphate. VGluTs are also expressed and localized in various secretory vesicles in non-neuronal peripheral organelles such as hormone-containing secretory granules in endocrine cells, and thus, also act as metabolic regulators. The VGluT subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340940 [Multi-domain] Cd Length: 380 Bit Score: 43.10 E-value: 2.52e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 60 QLGFVISAALIGLALGAIFSGPLADWLGRKKIIINSVFFFGFWTIATALSQNIEQ--MMVFRFLTGLGLGAAMPNIGTLV 137
Cdd:cd17382 50 TVGLIESSFFWGYLVTQIPGGFIAAKFAANRVFGLAIFVTSTLNMLIPIAARVHYgcVIFVRILQGLVEGVTYPACHGIW 129
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 503994177 138 SEYAPERQRSFLITIIFCGFTFGAAAGGFSASWLIPQFGWHSLMLLGGILPLLFAPVLIWL 198
Cdd:cd17382 130 RKWAPPLERSRLATTAFCGSYAGAVVGMPLSGILVQYVGWSSPFYVYGVFGIIWYMFWMLV 190
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
251-426 |
2.75e-04 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 42.88 E-value: 2.75e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 251 SRQYRFGSMMLWLVYFMGLFLVYLLGSWLPTLVKEVGLTVGQAAVMTAMYQAGGTLGSLFAGWLMDRINPHRALGLIYAV 330
Cdd:COG0477 9 TRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLL 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 331 GGLFTMAMGYaAASFALICLLAFISGACLNGANTGMNALSARYYPTEARATGSSWMHGVGRMGAILSAFAGAeMLALNIS 410
Cdd:COG0477 89 FGLASLLCGL-APSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGG-LLVAALG 166
|
170
....*....|....*.
gi 503994177 411 FESVFLILGIPAAITV 426
Cdd:COG0477 167 WRWIFLINAPLGLLAL 182
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
20-196 |
2.85e-04 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 42.80 E-value: 2.85e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 20 RFQKLVVFLGFCVIALDGFDIAIMGFIAPTLKQEWGVSNHQLGFVISAALIGLALGAIFSGPLAD-WLGRKKIIINSVFF 98
Cdd:cd06174 200 LKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDrLIGRKPLLLIGLLL 279
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 99 FGFWTIATALSQNIEQMMVFRFLTGLGLGAAMPNIGTLVSEYAPERQRSFLITIIFCGFTFGAAAGGFSASWLIPQ-FGW 177
Cdd:cd06174 280 MALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAAtFGL 359
|
170
....*....|....*....
gi 503994177 178 HSLMLLGGILPLLFAPVLI 196
Cdd:cd06174 360 TGAFLVLAVLLLLAAILLL 378
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
52-196 |
3.10e-04 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 42.92 E-value: 3.10e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 52 QEWGVSNHQLGFVISAALIGLALGAIFSGPLADWLGRKKIIINSVFFFGFWTIATALSQNIEQMMVFRFLTGLGLGAAMP 131
Cdd:cd17370 227 QELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQES 306
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 503994177 132 NIGTLVSEYAPERQRSFLITIIFCGFTFGAAAGGFSASWLIPQFGWHSLMLLGGILPLLFAPVLI 196
Cdd:cd17370 307 IERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLFSAVLALIALLLLL 371
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
66-429 |
3.57e-04 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 42.53 E-value: 3.57e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 66 SAALIGLALGA---------IFSGPLADWLGRKKIIInsvfFFGFWTIAT-----ALSQNIEQMMVFRFLTGLGLGAAMP 131
Cdd:cd17370 32 SAAAVGLIEGLaealgsllrLFSGYLSDRTGKRKPLV----ILGYGLSALakpllALAGSWQLVLLLRILERLGKGIRTP 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 132 NIGTLVSEYAPERQRSFLITIIFCGFTFGAAAGGFSASWLIPQFGWH-SLMLLGGILPLLFAPVLIWLLPESVRFLVVKR 210
Cdd:cd17370 108 PRDALLADATPPSGRGKAFGLHRALDTLGAVLGPLLAALLLYLLGGNyRTIFLLAAIPALLALLILLFVVKEYPRPPKLR 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 211 APAERIR-RIMQRLYPGqipdeaefslpaqpvqanamrivlsrqYRFGSMMLWLVYFMGLFLVYLlgswlptlVKEVGLT 289
Cdd:cd17370 188 KKSKKTSlKKLPKAFWL---------------------------YLLAVALFALGNFSFAFLILR--------AQELGLS 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 290 VGQAAVMTAMYQAGGTLGSLFAGWLMDRINPHRALGLIYAVGGLFTMAMGYaAASFALICLLAFISGACLNGANTGMNAL 369
Cdd:cd17370 233 AALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFAL-GSSLWLLLLGFILWGLYMGAQESIERAA 311
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 503994177 370 SARYYPTEARATGSSWMH-GVGRMGAILSAFAGAemLALNISFESVFLILGIPAAITVAGL 429
Cdd:cd17370 312 VADLVPAELRGTAYGLFNtVVGIGWLLASLIAGY--LWDLISPSAAFLFSAVLALIALLLL 370
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
66-219 |
4.16e-04 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 42.59 E-value: 4.16e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 66 SAALIGLALG------AIFSGP---LADWLGRKKIIINSVFFFGFWTIATALSQNIEQMMVFRFLTGLGLGAAMpnIGTL 136
Cdd:cd17472 30 TPTLIGLALGiygltqAIFQIPfglLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQGSGAISSV--VMAL 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 137 VSEYAPE--RQRSFLITIIFCGFTFGAAaggFSASWLIPQ-FGWHSLMLLGGILPLLFAPVLIWLLPESVRFLVVKRAPA 213
Cdd:cd17472 108 LADLTREenRTKAMALIGASIGIAFAIS---MVLGPLLAAhLGVSGLFLITAILSLVSLLILLFFVPDPPKIVQISEKEK 184
|
....*.
gi 503994177 214 ERIRRI 219
Cdd:cd17472 185 KKLKKL 190
|
|
| MFS_SLC45_SUC |
cd17313 |
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ... |
72-186 |
4.74e-04 |
|
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340871 [Multi-domain] Cd Length: 421 Bit Score: 42.23 E-value: 4.74e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 72 LALGAIFSGPLADWLGRKKIIINSVFFFGFWTIATALSQNIEQMMVFRFLTGLGLGAAMPNIGTLVSEYAPERQRSF--L 149
Cdd:cd17313 294 FLIFSLPIGKLGKKIGRKKVYLIGLVLFAVGMALMALVHNVTVALVLFALGGIGWATININPYPLVSDYHSESGRGQgtD 373
|
90 100 110
....*....|....*....|....*....|....*..
gi 503994177 150 ITIIFCGFTFGAAAGGFSASWLIPQFGWHSLMLLGGI 186
Cdd:cd17313 374 TGLLNLAISLAQILVSLLAGPIIDVKGYGTVFPVAAV 410
|
|
| MFS_CsbX |
cd17337 |
CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed ... |
44-217 |
5.62e-04 |
|
CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed of Bacillus subtilis CsbX protein (also named alpha-ketoglutarate permease), Klebsiella pneumoniae D-arabinitol transporter (DalT), and similar proteins. The csbX gene is a sigmaB-controlled gene that is expressed during the stationary phase of cell growth. DalT is a pentose-specific ion symporter for D-arabinitol uptake. Most members of this family remain uncharacterized. The CsbX family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340895 [Multi-domain] Cd Length: 388 Bit Score: 42.10 E-value: 5.62e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 44 GFIAPTLKQEwGVSNHQLGFVISAALIGLALGAIFSGPLADWLGRKKI-----IINSVFFFGFWTIATAlSQNIEQMMVF 118
Cdd:cd17337 18 GFLSPYLVDL-GFSEAQAALLFTVYGLTVAIASWLSGVLAELFGPRRVmliglIIWLVFEVLFLAFGLP-SHNYPLMLLT 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 119 RFLTGLGLGAAMPNIGTLVSEYAPERQRSFLITIIFCGFTFG-AAAGGFSASWLIPQFGWHSLMLLGGILPLLFAPVLIW 197
Cdd:cd17337 96 YGLRGFGYPLFAYSFLVWITYRTPAERLGSAVGWFWFAFTGGlPVLGSYLASFTIPVIGEIGTLWLSLVFVALGGLIALF 175
|
170 180
....*....|....*....|
gi 503994177 198 LLPESVRFLVVKRAPAERIR 217
Cdd:cd17337 176 LVRDRTGEQPLANPSEEPLK 195
|
|
| PRK11043 |
PRK11043 |
Bcr/CflA family multidrug efflux MFS transporter; |
69-197 |
5.86e-04 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182924 [Multi-domain] Cd Length: 401 Bit Score: 42.19 E-value: 5.86e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 69 LIGLALGAIFSGPLADWLGRKKIIINSVFFFGFWTIATALSQNIEQMMVFRFLTGLGLGAAMPNIGTLVSEYAPERQRSF 148
Cdd:PRK11043 51 LAGFALGQLLWGPLSDRYGRKPVLLAGLSLFALGSLGMLWVESAAQLLVLRFVQAVGVCSAAVIWQALVIDRYPAQKANR 130
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 503994177 149 LITIIFCGFTFGAAAGGFSASWLIPQFGWHSL-MLLGGILPLLFAPVLIW 197
Cdd:PRK11043 131 VFATIMPLVALSPALAPLLGAWLLNHFGWQAIfATLFAITLLLILPTLRL 180
|
|
| PRK11646 |
PRK11646 |
multidrug efflux MFS transporter MdtH; |
60-200 |
6.48e-04 |
|
multidrug efflux MFS transporter MdtH;
Pssm-ID: 183255 Cd Length: 400 Bit Score: 41.97 E-value: 6.48e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 60 QLGFviSAALIGLALG---------AIFSGPLADWLGRKKIIINSVFF--FGFWTIATALSQNIeqMMVFRFLTGLGLGA 128
Cdd:PRK11646 40 QLGW--AAVMVGIALGlrqfiqqglGIFGGAIADRFGAKPMIVTGMLMraAGFATMAIAHEPWL--LWLSCILSGLGGTL 115
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 503994177 129 AMPNIGTLVSEYAPERQRSFLITIIFCGFTFGAAAGGFSASWLIpQFGWHSLMLLGGILPLLFAPVLIWLLP 200
Cdd:PRK11646 116 FDPPRTALVIKLIRPHQRGRFFSLLMMQDSAGAVIGALLGSWLL-QYDFRLVCATGAVLFVLAAAFNAWLLP 186
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
41-201 |
8.01e-04 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 41.52 E-value: 8.01e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 41 AIMGFIAPTLKQEWGVSNHQLGFVISAALIGLALGAIFSGPLADWLGRKKIIInsVFFFGFWTIATALSQ---NIEQMMV 117
Cdd:cd17371 227 GITTWLPSYLTGERGLSFEGSAGYLVVTILGGFLGYLAGGFLADRIGRRNNFA--LFALGSAISILLYFFlplSPTLILI 304
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 118 FRFLTGLGLGAAMPNIGTLVSEYAPERQRSFLITIIFCGFTFGAAAGGFSASWLIPQFGWHSLMLLGGILPLLFAPVLIW 197
Cdd:cd17371 305 LGFPLGFFASGPFSGMGAYLTELFPTAVRATAQGFCYNVGRIIGALFPFLVGFLATSGSLGTAIAVFAAVYYIAGLVLAL 384
|
....
gi 503994177 198 LLPE 201
Cdd:cd17371 385 LLPE 388
|
|
| MFS_SVOPL |
cd17442 |
Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) of the Major Facilitator Superfamily; ... |
24-186 |
1.13e-03 |
|
Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) or SVOP-like protein is a transporter-like protein that shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. It belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341000 [Multi-domain] Cd Length: 375 Bit Score: 40.95 E-value: 1.13e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 24 LVVFLGFCVIAlDGFDIAIMGFIAPTLKQEWGVSNHQLGFVISAALIGLALGAIFSGPLADWLGRKKIIINSVFFFGFWT 103
Cdd:cd17442 2 LFLIMGSTGVA-EAMEIMLLAVVSPEIRCEWHLEDWQVALVTTMVFFGYMVFSILLGLLADRYGRWKILLLSFVWGAYFS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 104 IATALSQNIEQMMVFRFLTGLGLGAAMPNIgTLVSEYAPERQRSFLITIIFCGFTFGAAAGGFSASWLIPQFGWHSLMLL 183
Cdd:cd17442 81 LLTSFAPSYIWFVFLRCMVGCGVSGHSQGL-IIKTEFLPTKYRGYMLPLSQIFWLAGSLLIIGLASVVIPTLGWRWLIRF 159
|
...
gi 503994177 184 GGI 186
Cdd:cd17442 160 ASI 162
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
64-172 |
1.55e-03 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 40.69 E-value: 1.55e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 64 VISAALIGLALGAIFSGPLADWLGRKKIII--NSVFFFGFwtIATALSQNIEQMMVFRFLTGLGLGAAmPNIGTLVSEYA 141
Cdd:cd06179 37 ISTAWSLAQAVLGPIVGRLSDLFGRRWFFIggNLLGVVGS--IVAGTAKSVNMLIGGQALIGIGAGTQ-GLGAAVASELV 113
|
90 100 110
....*....|....*....|....*....|.
gi 503994177 142 PERQRSFLITIIFCGFTFGAAAGGFSASWLI 172
Cdd:cd06179 114 PNKYRGLVQGVVNLVASPGSALGPLIAGALV 144
|
|
| MFS_ProP |
cd17366 |
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This ... |
34-190 |
1.79e-03 |
|
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of Escherichia coli proline/betaine transporter, also called proline porter II (PPII), and similar proteins. ProP is a proton symporter that senses osmotic shifts and responds by importing osmolytes such as proline, glycine betaine, stachydrine, pipecolic acid, ectoine and taurine. It is both an osmosensor and an osmoregulator which is available to participate early in the bacterial osmoregulatory response. The ProP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340924 [Multi-domain] Cd Length: 377 Bit Score: 40.42 E-value: 1.79e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 34 ALDGFDIAIMGFIAPTLKQEW-GVSNHQLGFVISAALIGLA-----LGAIFSGPLADWLGRKKIIINSVFFFGFWTIATA 107
Cdd:cd17366 9 AMEWFDFGVYGYLAVTIGKVFfPGGDPTAQLLATFATFAVAflvrpLGGLVFGPLGDKYGRQKVLAITIILMAASTFCIG 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 108 LSQNIEQ--------MMVFRFLTGLGLGAAMPNIGTLVSEYAPERQRSFLITIIFCGFTFGAAAGG---FSASWLIPQ-- 174
Cdd:cd17366 89 LLPTYATigvwapilLLLARMVQGFSTGGEYGGAATFVAEYAPDRKRGFLGSWLEFGTLAGFILGAglvTLLTLLLTEaq 168
|
170
....*....|....*....
gi 503994177 175 ---FGWHSLMLLGGILPLL 190
Cdd:cd17366 169 mldWGWRIPFLIAAPLGLV 187
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
17-164 |
2.02e-03 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 40.25 E-value: 2.02e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 17 PLSRFQKLVVFLGFCVIALDGFDIAIMGFIAPTLKQewgvSNHQLGFVISAALIGL-----ALGAIFSGPLADWL----- 86
Cdd:cd17504 170 DLRLLRRRNVLLANITALLAGFGMFMVFQLLPQLLQ----LPTPTGFGLGITEAGLlllpgALVMLIAGPLAGRLiarvg 245
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 503994177 87 GRKKIIINSVFFFGFWTIATALSQNIEQMMVFRFLTGLGLGAAMPNIGTLVSEYAPERQRSFLITIIFCGFTFGAAAG 164
Cdd:cd17504 246 PRRVLLIGLVISAVGLLLLALLHSSLWALVVALLLIGIGLGLAFASLPNIVVESVPPDRTGIATGMNTVLRTIGSAIG 323
|
|
| MFS_YdiM_like |
cd17396 |
Inner membrane transport protein YdiM and similar proteins of the Major Facilitator ... |
34-123 |
2.09e-03 |
|
Inner membrane transport protein YdiM and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily contains Escherichia coli inner membrane transport proteins YdiM and YdiN, which belong to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340954 [Multi-domain] Cd Length: 384 Bit Score: 40.41 E-value: 2.09e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 34 ALDGFDIAIMGFIAPTLKQEWGVSNHQLGFVISAALIGLALGAIFSGPLADWLGRKKIIINSVFFFGFWTIATALSQNIE 113
Cdd:cd17396 10 FVHGMGVIILAQNMSSLSEKWHTDVAGVAYVISGIGIGRLLTILFAGVLSDKFGRKPSVLLGMVLYALFFVGILFSPNLI 89
|
90
....*....|
gi 503994177 114 QMMVFRFLTG 123
Cdd:cd17396 90 IAYVFALLAG 99
|
|
| MFS_NIMT_like |
cd17409 |
2-nitroimidazole transporter and similar proteins of the Major Facilitator Superfamily of ... |
266-359 |
2.53e-03 |
|
2-nitroimidazole transporter and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Escherichia coli 2-nitroimidazole transporter (NIMT), also called YeaN, and similar proteins. NIMT confers resistance to 2-nitroimidazole, the antibacterial and antifungal antibiotic, by mediating the active efflux of this compound. The NIMT-like subfamily belongs to the 2-nitroimidazole and cyanate transporters like (NIMT/CynX-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340967 [Multi-domain] Cd Length: 374 Bit Score: 39.94 E-value: 2.53e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 266 FMGL--FLVYLLGSWLPTLVKEVGLTVGQAAVMTAMYQAGGTLGSLFAGWLMDRINPHRALGLIYAVGGLFTMAMGYAAA 343
Cdd:cd17409 205 FLGLnsFIYYVLVGWLPSILTDAGYSAAQAGSLHGLLQLATAVPGLLLIPVLARMKDQRLLAVLVSLLGAVGLIGLLLAP 284
|
90
....*....|....*...
gi 503994177 344 SFALI--CLLAFISGACL 359
Cdd:cd17409 285 SLAILwvILFGFGSGAGF 302
|
|
| MFS_SLC22A15 |
cd17377 |
Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; ... |
71-124 |
2.54e-03 |
|
Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 15 (SLC22A15) is also called fly-like putative transporter 1 (FLIPT1). It is expressed at the highest levels in the kidney and brain. It is a member of the SLC22 family of transporters, which includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A15 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340935 [Multi-domain] Cd Length: 353 Bit Score: 39.76 E-value: 2.54e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 503994177 71 GLALGAIFSGPLADWLGRKKIIINSVFFFGFWTIATALSQNIEQMMVFRFLTGL 124
Cdd:cd17377 51 GVLIGVVSFGQLSDRFGRKPVYLTGLALDILFAYFNALAPSYEFFAVSRFLVGV 104
|
|
| 2A0108 |
TIGR00886 |
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions] |
49-366 |
2.74e-03 |
|
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]
Pssm-ID: 273322 [Multi-domain] Cd Length: 354 Bit Score: 39.59 E-value: 2.74e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 49 TLKQEWGVSNHQLGFVISAALIGLALGAIFSGPLADWLGRKKIIINSVFFFGFWTIATALS-QNIEQMMVFRFLTGLGLG 127
Cdd:TIGR00886 27 LIKDDLGLSTAQLGNLVAVPVLAGAVLRIILGFLVDIFGPRYTTALSLLLLAIPCLWAGLAvQSYSVLLLIRLFIGIAGG 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 128 A---AMPNIgtlvSEYAPERQRSFLITIIFCGFTFGAAAGGFSASWLIPQ--FGWHSLMLLGGILPLLFAPVLIWLLPES 202
Cdd:TIGR00886 107 SfasCMPWI----SFFFPKKIQGTALGLAAGWGNMGGGVAQFVMPPIIGSliFGGGQPAHLAWGWAFVIVPAGILLLPAL 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 203 VRFLVVKRAPAERirrimqrlypgqiPDEAEFSLPAQpvqanaMRIVLSRQYRFgsMMLWLVYFMGLFLVYllGSWLPTL 282
Cdd:TIGR00886 183 LIFFVGADTPPGK-------------PATGKLSFKEA------LKVFGNRHTWI--LALLYSVTFGSFLGV--SSIFAML 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 283 VKEV-GLTVGQAAVMTAMYQAGGTLGSLFAGWLMDRINPHRALGLIY--AVGGLFTMAMGY-----AAASFALICLLAFI 354
Cdd:TIGR00886 240 FKDQfGLSKVQAGAYASLGGFLGSLARPAGGAISDRLGGARKLLMNFlgVAMGAFLVVLGLvsdgsLAAFIVLFVALFFF 319
|
330
....*....|..
gi 503994177 355 SGAClNGANTGM 366
Cdd:TIGR00886 320 AGAG-NGSTFAL 330
|
|
| PRK10473 |
PRK10473 |
MdtL family multidrug efflux MFS transporter; |
48-128 |
2.81e-03 |
|
MdtL family multidrug efflux MFS transporter;
Pssm-ID: 182486 [Multi-domain] Cd Length: 392 Bit Score: 40.00 E-value: 2.81e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 48 PTLKQEWGVSNHQLGFVISAALIGLALGAIFSGPLADWLGRKKIIINSVFFFGFWTIATALSQNIEQMMVFRFLTGLGLG 127
Cdd:PRK10473 27 PRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKIADRSGRKPVAIPGAALFIIASLLCSLAETSSLFLAGRFLQGIGAG 106
|
.
gi 503994177 128 A 128
Cdd:PRK10473 107 C 107
|
|
| MFS_OCT_plant |
cd17378 |
Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of ... |
52-160 |
3.26e-03 |
|
Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of transporters; Plant organic cation/carnitine transporters (OCTs) are sequence-similar to their animal counterparts, which are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. Little is know about plant OCTs. In Arabidopsis, there are six genes belonging to this family that show distinct, organ-specific expression pattern of the individual genes. AtOCT1 has been found to affect root development and carnitine-related responses in Arabidopsis. AtOCT4, 5 and 6 are up-regulated during drought stress, AtOCT3 and 5 during cold stress and AtOCT5 and 6 during salt stress treatments. Plant OCTs belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340936 [Multi-domain] Cd Length: 342 Bit Score: 39.65 E-value: 3.26e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 52 QEWGV---SNHQLGFVISAALIGLALGAIFSGPLAD-WLGRKKIIINSVFFFGFWTIATALSQNIEQMMVFRFLTGLGLG 127
Cdd:cd17378 23 SEWGLicaGSFLVGLPQSSFFVGCLIGSGVLGHLADsSLGRKNLLFLSCLLMALSGIATAFSPNYWVYAFLRFLTGFGRS 102
|
90 100 110
....*....|....*....|....*....|...
gi 503994177 128 AAMPNIGTLVSEYAPERQRSFLITIIFCGFTFG 160
Cdd:cd17378 103 GIGTCALVLATEPVGPKWRGQVGMSTFFFFVLG 135
|
|
| emrD |
PRK11652 |
multidrug transporter EmrD; |
48-129 |
3.83e-03 |
|
multidrug transporter EmrD;
Pssm-ID: 183259 [Multi-domain] Cd Length: 394 Bit Score: 39.51 E-value: 3.83e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 48 PTLKQEWGVSNHQLGFVISAALIGLALGAIFSGPLADWLGRKKIIINSVFFFGFWTIATALSQNIEQMMVFRFLTGLGLG 127
Cdd:PRK11652 32 ADMARDLNVREGAVQAVMAAYLLTYGLSQLFYGPLSDRVGRRPVILVGMSIFILGTLVALFAHSLTVLIAASAIQGLGTG 111
|
..
gi 503994177 128 AA 129
Cdd:PRK11652 112 VG 113
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
43-147 |
4.13e-03 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 39.13 E-value: 4.13e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 43 MGFIaPTLKQEWGVSNHQLGFVISAALIGLALGAIFSGPLA-DWLGRKKIIINSVFFFGFWTIATALSQNIEQMMVFRFL 121
Cdd:cd17490 215 FGFT-PLIAKQLGASSFQLGLLSIIYLLPNALASLLSGTLFyKKLGERNTIIIGFLLLGAYCFLIPFAPNLTLLYLLQAL 293
|
90 100
....*....|....*....|....*.
gi 503994177 122 TGLGLGAAMPNIGTLVSEYAPERQRS 147
Cdd:cd17490 294 NGFGTGILFPLLMSLSIEGVPAEQRS 319
|
|
| PRK14995 |
PRK14995 |
SmvA family efflux MFS transporter; |
39-200 |
5.10e-03 |
|
SmvA family efflux MFS transporter;
Pssm-ID: 184957 [Multi-domain] Cd Length: 495 Bit Score: 39.33 E-value: 5.10e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 39 DIAIMGFIAPTLKQEWGVSNHQLGFVISAALIGLALGAIFSGPLADWLGRKKIIINSVFFFGFWTIATALSQNIEQMMVF 118
Cdd:PRK14995 21 DATVLHVAAPTLSMTLGASGNELLWIIDIYSLVMAGMVLPMGALGDRIGFKRLLMLGGTLFGLASLAAAFSPTASWLIAT 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 119 RFLtgLGLGAAMPNIGTLV---SEYAPERQRSFLITIIFCGFTFGAAAGGFSASWLIPQFGWHSLMLLGGILPLLFAPVL 195
Cdd:PRK14995 101 RAL--LAIGAAMIVPATLAgirATFTEEKQRNMALGVWAAVGSGGAAFGPLVGGILLEHFYWGSVFLINVPIVLVVMGLT 178
|
....*
gi 503994177 196 IWLLP 200
Cdd:PRK14995 179 ARYVP 183
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
55-381 |
6.40e-03 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 38.74 E-value: 6.40e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 55 GVSNHQLGFVISAALIGLALGAIFSGPLADWLGRKKIIINSVFFF-GFWTIATALSQNIEQMMVFRFLTGLGLGAAMPNI 133
Cdd:cd17490 27 GASLSMIGIILGAYGISQMLLRIPLGILSDRIGKRKLFIIIGLLFtVLASLIMILFPSPWGLLIARFLSGIAAATWVSFT 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 134 GTLVSEYAPERQRSFLITIIFC---GFTFGAAAGGFSASwlipQFGWHSLMLLGGILPLLfAPVLIWLLPEsvrflvvKR 210
Cdd:cd17490 107 VLYASYFPPDEAAKAMGLINLVnnlGQLIAFLIGGLIAE----HFGMRAPFLLAALAGVL-GFILSLFIKE-------ER 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 211 APAERIRRIMQRLypgqipdeaeFSLPAQPvqanamrivlsrqyrfgsmMLWLVYFMGLFLVYLLGS----WLPTLVKEV 286
Cdd:cd17490 175 REKKPVLTELKEL----------LSVLKDK-------------------KLLFFSLLAILQQMITFSttfgFTPLIAKQL 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 287 GLTVGQAAVMTAMYQAGGTLGSLFAGWLM-DRINPHRALGLIYAVGGLFTMAMGYAAASFALICLLAfisgacLNGANTG 365
Cdd:cd17490 226 GASSFQLGLLSIIYLLPNALASLLSGTLFyKKLGERNTIIIGFLLLGAYCFLIPFAPNLTLLYLLQA------LNGFGTG 299
|
330 340
....*....|....*....|.
gi 503994177 366 MN-----ALSARYYPTEARAT 381
Cdd:cd17490 300 ILfpllmSLSIEGVPAEQRST 320
|
|
| MFS_MFSD3 |
cd17485 |
Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily ... |
156-427 |
9.25e-03 |
|
Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily domain containing 3 protein (MFSD3) is a predicted acetyl-CoA transporter. As an atypical putative membrane-bound solute carrier (SLC), MFSD3 is most likely to be functionally active in the plasma membrane and not in any intracellular organelles. MFSD3 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341038 [Multi-domain] Cd Length: 386 Bit Score: 38.36 E-value: 9.25e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 156 GFTFGAAAGGFSASWLIPQFGWHSLML-LGGILPLLFAPVLIW---LLPESVRFLVVKRAPAERIRRIMQRlyPGQIPde 231
Cdd:cd17485 136 GYKLGSLLGGGGLLWLYDLIGWQSLLLsLAALYLLLLLPVLFLrelELPQQPPASERGAALKASLRAFLRR--PGTRW-- 211
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 232 aefslpaqpvqanamRIVLSRQYRFGSMMlwlvyFMGLFLVYLLgswlptlvkEVGLTVGQAAVMTAMY-QAGGTLGSLF 310
Cdd:cd17485 212 ---------------LLLFLLLYKLGEQG-----ALAMLPPFLV---------DRGFSLSQIGLLSGVGgSLVSIAGSLL 262
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503994177 311 AGWLMDRINPHRAL----GLIYAVGGLFTMAMGYAAAS-----FALICLLAFISGACLNGANTGMNALSARYYPTEARAT 381
Cdd:cd17485 263 GGYLLKRRGRRRLLllggLLRLLLLGLYTLLALGGSGLnwvllLASLALLHLVGGMITTALFTLMMDCSQQAQAGTDYTL 342
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 503994177 382 GSSWMHGVGRMGAILSAFagaemLALNISFESVFLILGIPAAITVA 427
Cdd:cd17485 343 LATVEVLGKLLFGSLAGF-----LADHLGYAAAFLLFAILSALSVL 383
|
|
| |
