|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
38-397 |
4.47e-80 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 251.31 E-value: 4.47e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 38 TLALFSAGLATFALLYCVQPILPVLSSEFGVSPASSSISLSISTAMLAVGLLFTGPLSDAIGRKQVMVTALVLASCCSLL 117
Cdd:cd17324 1 LLALALAAFAIGTTEYVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 118 STMMSSWHGILMMRALIGLSLSGVAAVGMTYLSEEIHPSVVAFSMGLYISGNSIGGMSGRLLTGVFTDFFGWRIALAVIS 197
Cdd:cd17324 81 AALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 198 GFALAAALMFWRILPESRHFRPTSLRPKSlliNFRLHWRDRGLPLLFLEGFLLMGSFVTLFNYIGYRLMLSPWSLSQAVV 277
Cdd:cd17324 161 VLALLAALLLWRLLPSLPPKKPGSLGLLS---SLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAII 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 278 GLLSVAYLTGTWSSPKAGAMTVRYGRGPVLLFSTAVMLGGLLLTLFS-SLWLIFIGMLLFSAGFFAAHSVASSWIGPRAR 356
Cdd:cd17324 238 GLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGpSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAP 317
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 503995541 357 RARGQASSLYLFSYYLGSSMAGTLGGVFWHNYGWNGVGGFI 397
Cdd:cd17324 318 EARGLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVG 358
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
36-377 |
2.91e-41 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 149.35 E-value: 2.91e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 36 RVTLALFSAGLATFALLYCVQPILPVLSSEFGVSPASSSISLSISTAMLAVGLLFTGPLSDAIGRKQVMVTALVLASCCS 115
Cdd:COG2814 10 LALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGS 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 116 LLSTMMSSWHGILMMRALIGLSLSGVAAVGMTYLSEEIHPSVVAFSMGLYISGNSIGGMSGRLLTGVFTDFFGWRIALAV 195
Cdd:COG2814 90 LLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLV 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 196 ISGFALAAALMFWRILPESRHFRPTSLRPkslliNFRLHWRDRGLPLLFLEGFLLMGSFVTLFNYIGYRLMLSPWSLSQA 275
Cdd:COG2814 170 NAVLALLALLLLLRLLPESRPAARARLRG-----SLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASA 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 276 VVGLLSVAYLTGTWSSPKAGAMTVRYGRGPVLLFSTAVMLGGL-LLTLFSSLWLIFIGMLLFSAGFFAAHSVASSWIGPR 354
Cdd:COG2814 245 AGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLlLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAEL 324
|
330 340
....*....|....*....|....
gi 503995541 355 A-RRARGQASSLYLFSYYLGSSMA 377
Cdd:COG2814 325 ApPEARGRASGLYNSAFFLGGPLA 348
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
41-393 |
2.21e-29 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 117.68 E-value: 2.21e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 41 LFSAGLATFALLYCVQPILPVLSSEFGVSPASSSISLSISTAMLAVGLLFTGPLSDAIGRKQVMVTALVLASCCSLLSTM 120
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 121 MSSWHGILMMRALIGLSLSGVAAVGMTYLSEEIHPSVVAFSMGLYISGNSIGGMSGRLLTGVFTDFFGWRIALAVISGFA 200
Cdd:cd17325 81 ATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 201 LAAALMFWRILPESRHFRPT-SLRPKSLLINFRLHWRDRGLPLLFLEGFLLMGSFVTLFNYIGYRLMlSPWSLSQAVVGL 279
Cdd:cd17325 161 LLALVLALLLLPEPRPPPNKrAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAA-ELGGLSPAQIGL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 280 L-SVAYLTGTWSSPKAGAMTVRYGRGPVLLFSTAVM-LGGLLLTLFSSLWLIFIGMLLFSAGFFAAHSVASSWIGPRA-R 356
Cdd:cd17325 240 LfGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSaVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVpP 319
|
330 340 350
....*....|....*....|....*....|....*..
gi 503995541 357 RARGQASSLYLFSYYLGSSMAGTLGGVFWHNYGWNGV 393
Cdd:cd17325 320 EGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATP 356
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
57-391 |
7.81e-24 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 101.88 E-value: 7.81e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 57 PILPVLSSEFGVSPASSSISLSISTAMLAVGLLFTGPLSDAIGRKQVMVTALVLASCCSLLSTMMSSWHGILMMRALIGL 136
Cdd:cd17320 20 PALPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGL 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 137 SLSGVAAVGMTYLSEEIHPSVVAFSMGLYISGNSIGGMSGRLLTGVFTDFFGWRIALAVISGFALAAALMFWRILPESRH 216
Cdd:cd17320 100 GAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLALLGLLLLLLVLLFLPETLP 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 217 FRPTSLRPKSLLINFRLHWRDRGlplLFLEGFLLMGSFVTLFNYIGYR--LMLSPWSLSQAVVGLL----SVAYLTGTWS 290
Cdd:cd17320 180 EEKRKPLLSSLLRAYKRVLKNRR---FLGYALALGLSFAGLFAYLAAApfIYIEQLGLSPAQFGLLfalnAIALILGSLL 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 291 SPKAG---AMTVRYGRGPVLLFSTAVMLGGLLLTLFSSLWLIFIGMLLFSAGFFAAHSVASSWIGPRARRARGQASSLYL 367
Cdd:cd17320 257 NGRLVrrfGPRRLLRLGLLLLLAAALVLLLAALLGGLSLWPLVAPLFLIFFGFGLIFPNATSLALEPFPHVAGTASALLG 336
|
330 340
....*....|....*....|....
gi 503995541 368 FSYYLGSSMAGTLGGVFWHNYGWN 391
Cdd:cd17320 337 FLQFLIGALAGALVGLLPNGTALP 360
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
55-393 |
5.39e-22 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 96.49 E-value: 5.39e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 55 VQPILPVLSSEFGVSPASSSISLSISTAMLAVGLLFTGPLSDAIGRKQVMVTALVLASCCSLLSTMMSSWHGILMMRALI 134
Cdd:cd17474 18 VDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALQ 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 135 GLSLSGVAAVGMTYLSEEIHPSVVAFSMGLYISGNSIGGMSGRLLTGVFTDfFGWRIALAVISGFALAAALMFWRILPES 214
Cdd:cd17474 98 GIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAA-ISWRYPFFLLAALIPVAFLAILFLLPEP 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 215 RhfRPTSLRPKSLLINFRLHWRDRGLPLLFLEGFLLMGSFVTLFNYIGYRLMLSPWSLSQAVVGLLSVAYLTGTWSSPKA 294
Cdd:cd17474 177 K--EKAKSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFV 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 295 GAMT-VRYGRGPVLLFSTAVMLGGLLLTLFS-SLWLIFIGMLLFSAGFFAAHSVASSWIGPRA-RRARGQASSLYLFSYY 371
Cdd:cd17474 255 GRLLkKRFGARRILVIGLLLYALSLLLLGFVpSLALLLIAIVLFGLGLGLNLPLLTTLVTELApEEERGTASSLYNFVRF 334
|
330 340
....*....|....*....|..
gi 503995541 372 LGSSMAGTLGGVFWHNYGWNGV 393
Cdd:cd17474 335 LGQAVGPLLFGLLLEIFGLSAP 356
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
20-385 |
4.02e-21 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 94.17 E-value: 4.02e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 20 APQPNQFIKRGTPQFIRVTLALFSAGLATFALLYCVQPILPVLSSEFGVSPASSSISLSISTAMLAVGLLFTGPLSDAIG 99
Cdd:COG2807 2 STTSSSARRSRRAGRWLLLLAIVLVALNLRPAITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 100 RKQVMVTALVLASCCSLLSTMMSSWHGILMMRALIGLSLsGVAAVGMTYLSEEIHPSVVAFSMGLYISGNSIGGMSGRLL 179
Cdd:COG2807 82 LERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGI-AVGNVLLPGLIKRWFPDRVGLMTGLYTAAMGLGAALAAGL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 180 TGVFTDFFGWRIALAVISGFALAAALMFWRILPESRHFRPTSLRPKSLlinfRLHWRDRGLPLLFLEGFLLMGSFVTLFN 259
Cdd:COG2807 161 TVPLAAALGWRGALAVWALLALLALLLWLPLLRRRPAAAAAAPAAASL----RSLWRSPLAWLLTLFFGLQSLLYYAVVA 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 260 YIGYRLMLSPWSLSQAvVGLLSVAYLTGTWSSPKAGAMTVRYG-RGPVLLFSTAVMLGGLLLTLFSSLWLIFIGMLLFSA 338
Cdd:COG2807 237 WLPPILRDAGLSAATA-GLLLSLFQLAGIPGSLLVPLLADRLGdRRPLLLLLGLLGLAGLLGLLLAPGSLPWLWAVLLGL 315
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 503995541 339 GFFAAHSVASSWIGPRARRAR--GQASSLYLFSYYLGSSMAGTLGGVFW 385
Cdd:COG2807 316 GQGGLFPLALTLIGLRARTPAeaAALSGMAQSVGYLLAALGPLLVGALH 364
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
36-340 |
1.06e-20 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 93.02 E-value: 1.06e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 36 RVTLALFSAGLATFALLYCVQPILPVLSSEFGVSPASSSISLSISTAMLAVGLLFTGPLSDAIGRKQVMVTALVLASCCS 115
Cdd:COG2223 5 RVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 116 LLSTMMSSWHGILMMRALIGLSLSGVAAVGMTYLSEEIHPSVVAFSMGLYISGNSIGGMSGRLLTGVFTDFFGWRIALAV 195
Cdd:COG2223 85 LLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLI 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 196 ISGFALAAALMFWRILPESRHFRPTSlrPKSLLINFRLHWRDRGLPLLFLEGFLLMGSFVTLFNYIGyRLMLSPWSLSQA 275
Cdd:COG2223 165 LGILLLVVAVLAWLFLRDPPAGAAAA--AKASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLP-PYLVDQFGLSAA 241
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 503995541 276 VVGLL-SVAYLTGTWSSPKAGAMTVRYGRGPVLLFSTAVMLGGLLLTLFS--SLWLIFIGMLLFSAGF 340
Cdd:COG2223 242 TAGLLaALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALAlgSLWLFLVLFLLLGLAL 309
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
41-377 |
1.32e-20 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 92.10 E-value: 1.32e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 41 LFSAGLATFALLYCVQPILP-VLSSEFGVSPASSSISLSISTAMLAVGLLFTGPLSDAIGRKQVMVTALVLASCCSLLST 119
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPlLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 120 MMSSWHGILMMRALIGLSLSGVAAVGMTYLSEEIHPSVVAFSMGLYISGNSIGGMSGRLLTGVFTDFFGWRIALAVISGF 199
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 200 ALAAALMFWRIL--PESRHFRPTSLRPKSLLINFRLHWRDRGLPLLFLeGFLLMGSFVTLFNYIGYRLMLSPWSLSQAVV 277
Cdd:pfam07690 161 SLLAAVLLLLPRppPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLA-LLLFGFAFFGLLTYLPLYQEVLGLSALLAGL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 278 gLLSVAYLTGTWSSPKAGAMTVRYGRGPVLLFSTAVMLGG----LLLTLFSSLWLIFIGMLLFSAGFFAAHSVASSWIGP 353
Cdd:pfam07690 240 -LLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAalglLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSD 318
|
330 340
....*....|....*....|....*
gi 503995541 354 RA-RRARGQASSLYLFSYYLGSSMA 377
Cdd:pfam07690 319 LApKEERGTASGLYNTAGSLGGALG 343
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
28-401 |
1.39e-20 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 92.24 E-value: 1.39e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 28 KRGTPQFIRVTLALFSAGLATFALLYCVQPILPVLSSEFGVSPASSSISLSISTAMLAVGLLFTGPLSDAIGRKQVMVTA 107
Cdd:COG2271 2 RAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 108 LVLASCCSLLSTMMSSWHGILMMRALIGLSLSGVAAVGMTYLSEEIHPSVVAFSMGLYISGNSIGGMSGRLLTGVFTDFF 187
Cdd:COG2271 82 LLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAF 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 188 GWRIALAVISGFAL-AAALMFWrilpesrhfrptslrpksllinfrlhwrdrglpLLFLEGFLLMGSFVTLFNYIGYRLM 266
Cdd:COG2271 162 GWRAAFLILGLPGLlLALLRFW---------------------------------LLALAYFLVYFALYGFLTWLPTYLV 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 267 LS-PWSLSQAVvGLLSVAYLTGTWSSPKAGAMTVRYGRG---PVLLFSTAVMLGGLLLTLFSSLWLIFIGMLLFSAGFFA 342
Cdd:COG2271 209 EVrGLSLAQAG-LLLSLPFLAGIVGSLLGGWLSDRLGRRrklVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGG 287
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 343 AHSVASSWIGPRA-RRARGQASSLYLFSYYLGSSMAGTLGGVFWHNYGWNGVGGFIALML 401
Cdd:COG2271 288 AFGLLWALAAELFpKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALA 347
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
14-343 |
1.85e-18 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 86.64 E-value: 1.85e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 14 DVSDIIAPQP-NQFIKRGtpqFIRVTLALFSAGLATFALLYcvqpILPVLSSEFGVSPASSSISLSISTAMLAVGLLFTG 92
Cdd:TIGR00895 1 DVQNNIRKQPlSRYQWRA---IILSFLIMLMDGYDLAAMGF----AAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFG 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 93 PLSDAIGRKQVMVTALVLASCCSLLSTMMSSWHGILMMRALIGLSLSGVAAVGMTYLSEEIHPSVVAFSMGLYISGNSIG 172
Cdd:TIGR00895 74 PLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIG 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 173 GMSGRLLTGVFTDFFGWRIALAVISGFALAAALMFWRILPESRHF----RPTSLRPKSLLINFRLHW------------- 235
Cdd:TIGR00895 154 AAVGGFLAGWLIPVFGWRSLFYVGGIAPLLLLLLLMRFLPESIDFlvskRPETVRRIVNAIAPQMQAeaqsalpeqkstq 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 236 --------------RDRGLPLLFLEGFLLMGSFVTLFNYIGYRLMLSPWSLSQAVVGLLSVaYLTGTWSSPKAGAMTVRY 301
Cdd:TIGR00895 234 gtkrsvfkalfqgkTARITVLLWLLYFMLLVGVYFLTNWLPKLMVELGFSLSLAATGGALF-NFGGVIGSIIFGWLADRL 312
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 503995541 302 GRGPVLLFStavMLGGLLLTLFSSLWLIFIGMLL--FSAGFFAA 343
Cdd:TIGR00895 313 GPRVTALLL---LLGAVFAVLVGSTLFSPTLLLLlgAIAGFFVN 353
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
41-384 |
3.45e-18 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 85.32 E-value: 3.45e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 41 LFSAGLATFALLYCVQPILPVLSSEFGVSPASSSISLsisTAMLAVGLLFT---GPLSDAIGRKQVMVTALVLASCCSLL 117
Cdd:cd17504 1 LALAALAVMLVETMLSPALPTIQREFGTSAAAVSWVL---TAYLLVGAVSTpilGRLGDLYGRKKVLLIVLAIYTAGSLL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 118 STMMSSWHGILMMRALIGLSLsGVAAVGMTYLSEEIHPSVVAFSMGLYISGNSIGGMSGRLLTGVFTDFFGWRIALAVIS 197
Cdd:cd17504 78 AAFAPNLPVLIAGRALQGIGG-AVFPLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 198 GFALAAALMfwrilpesrhfrptslrpkSLLINFRLhWRDRGLPLLFLEGFLLMGSFVTLFNYIGYRLMLSPWS---LSQ 274
Cdd:cd17504 157 PVAVLLAAL-------------------VPLIDLRL-LRRRNVLLANITALLAGFGMFMVFQLLPQLLQLPTPTgfgLGI 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 275 AVVGLLSVAY-LTGTWSSPKAGAMTVRYGRGPVLLFSTAVMLGGLLLTLF--SSLWLIFIGMLLFSAGF-FAAHSVASSW 350
Cdd:cd17504 217 TEAGLLLLPGaLVMLIAGPLAGRLIARVGPRRVLLIGLVISAVGLLLLALlhSSLWALVVALLLIGIGLgLAFASLPNIV 296
|
330 340 350
....*....|....*....|....*....|....
gi 503995541 351 IGPRARRARGQASSLYLFSYYLGSSMAGTLGGVF 384
Cdd:cd17504 297 VESVPPDRTGIATGMNTVLRTIGSAIGPAIAGAI 330
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
41-385 |
5.35e-18 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 84.79 E-value: 5.35e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 41 LFSAGLATFALLYCVQPILPVLSSEFGVSPASSSISLSISTAMLAVGLLFTGPLSDAIGRKQVMVTALVLASCCSLLSTM 120
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 121 MSSWHGILMMRALIGLSLSGVAAVGMTYLSEEIHPSVVAFSMGLYISGNSIGGMSGRLLTGVFTDF--FGWRIALAVISG 198
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSlgFGWRAVFLIAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 199 FALAAALMFWRILPESRH---FRPTSLRPKSLLINFRLHWRDRGLPLLFLEGFLLMGSFVTLFNYIGYRLMLSPWSLSQA 275
Cdd:cd06174 161 LALLAAILLLLVVPDPPEsarAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAV 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 276 VVGLLSVAYLTGTWSSPKAGAMTVRYGRGPVLLFSTAV--MLGGLLLTLFSSLWLIFIGMLLFSAGFFAAHSVASSWIG- 352
Cdd:cd06174 241 AGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLlmALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAe 320
|
330 340 350
....*....|....*....|....*....|...
gi 503995541 353 PRARRARGQASSLYLFSYYLGSSMAGTLGGVFW 385
Cdd:cd06174 321 LFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLL 353
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
58-384 |
1.21e-15 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 77.98 E-value: 1.21e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 58 ILPVLSSEFGVSPASSSISLSISTAMLAVGLLFTGPLSDAIGRKQVMVTALVLASCCSLLSTMMSSWHGILMMRALIGLS 137
Cdd:cd17321 18 ALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAARALQGIG 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 138 LSGVAAVGMTYLSEEIHPSVVAFSMGLYISGNSIGGMSGRLLTGVFTDFFGWRIALAVISGFALAAALMfwrilpeSRHF 217
Cdd:cd17321 98 AAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIGLVALLL-------ARTF 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 218 RPTSLrpksllinfrlhwrdrglpLLFLEGFLLMGSFVTLFNYIGYRLMLSPWSlsqavVGLLSVAY-LTGTWSSPKAGA 296
Cdd:cd17321 171 SGAVL-------------------AAFLLGAALGGLLFLLPLYLQGVLGYSPLQ-----AGLALLPLaLAMLVAAPLAGR 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 297 MTVRYGRGPVLLFSTAVMLGGLLLTLF----SSLWLIFIGMLLFSAGF-FAAHSVASSWIGPRARRARGQASSLYLFSYY 371
Cdd:cd17321 227 LADRFGPRLVLVAGLLLTAVGLLLLALlgadSSVWLLLPGLVLLGLGLgLFATPLTNAALSSVPKEKAGAASGILNTARQ 306
|
330
....*....|...
gi 503995541 372 LGSSMAGTLGGVF 384
Cdd:cd17321 307 LGGALGVALLGAL 319
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
55-383 |
2.06e-15 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 77.21 E-value: 2.06e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 55 VQPILPVLSSEFGVSPASSSISLSISTAMLAVGLLFTGPLSDAIGRKQVMVTALVLASCCSLLSTMMSSWHGILMMRALI 134
Cdd:cd17478 15 LPALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALA 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 135 GLSLSGVAAVGMTYLSEeIHPSVVAFSMGLYISGNSIGGMSGRLLTGVFTDFFGWRIALAVISGFALAAALMFWRILPES 214
Cdd:cd17478 95 GIGSAAFHPEGARLASQ-AAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLLLRLRPLK 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 215 RHFRPTSLRPKSLLINFRLHWRdrglPLLFLEGFLLMGSFVT--LFNYIGYRLMLSPWSLSQAVVgLLSVAYLTGTWSSP 292
Cdd:cd17478 174 KPEAKKAAAKSSARSTLKGVWR----ALLLLLIIVFLRSWVLssLTTFLPFYLVQRGYSLVFAGL-LLSLFLFAGAIGTL 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 293 KAGAMTVRYGRGPVLLFSTAVMLGGLLLTLFSSLWLIFIGMLLFSAGFFAAHSVASSWIGPRARRARGQASSLYL-FSYY 371
Cdd:cd17478 249 IGGPLSDRFGRRRVIIASLLLAAPFLLLFLLTPGIWSYILLVLAGFLLFASFPVTVVLAQELLPGNVGLASGLMMgLSFG 328
|
330
....*....|..
gi 503995541 372 LGSSMAGTLGGV 383
Cdd:cd17478 329 LGGIGAPVLGAL 340
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
35-318 |
5.67e-15 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 74.85 E-value: 5.67e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 35 IRVTLALFSAGLATFALLYCVQPILPVLSSEFGVSPASSSISLSISTAMLAVGLLFTGPLSDAIGRKQVMVTALVLASCC 114
Cdd:COG0477 13 RRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 115 SLLSTMMSSWHGILMMRALIGLSLSGVAAVGMTYLSEEIHPSVVAFSMGLYISGNSIGGMSGRLLTGVFTDFFGWRIALA 194
Cdd:COG0477 93 SLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFL 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 195 VISGFALAAALMFWRiLPESRHFRPTSLRPKSLLINFRLHWRDRGLPLLFLEGFLLMGSFVTLFNYIGYRLMLSPWSLSQ 274
Cdd:COG0477 173 INAPLGLLALVLRLR-LPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALL 251
|
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 503995541 275 AVVGLLSVAYLTGTWSSPKAGAMTVRYGRGPVLLFSTAVMLGGL 318
Cdd:COG0477 252 LLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLALLL 295
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
92-397 |
2.70e-14 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 73.79 E-value: 2.70e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 92 GPLSDAIGRKQVMVTALVLASCCSLLSTMMSSWHGILMMRALIGlslSG-VAAVGMTYLSEEIHPSVVAFSMGLYISGNS 170
Cdd:cd17472 53 GLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQG---SGaISSVVMALLADLTREENRTKAMALIGASIG 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 171 IGGMSGRLLTGVFTDFFGWRIALAVISGFALAAALMFWRILPESRHFRPTSLRPKSLLINFRLHWRDRGLPLL-FLEGFL 249
Cdd:cd17472 130 IAFAISMVLGPLLAAHLGVSGLFLITAILSLVSLLILLFFVPDPPKIVQISEKEKKKLKKLLKNKRLLRLDFSiFILHFV 209
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 250 LMGSFVTLfnyigyrlmlsPWSLSQAVVGLLSV--AYLTGTWSSPKAGAMTVRYGRG-----PVLLFSTAVMLGGLLLTL 322
Cdd:cd17472 210 LMAFFYIL-----------PLLLTQLGGGKGQLwkVYLPAILIGFILMVPFVIYAEKkgkmkQVFVSSILLIAVGFLLLL 278
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 503995541 323 FS--SLWLIFIGMLLFSAGFFAAHSVASSWIGPRAR-RARGQASSLYLFSYYLGSSMAGTLGGVFWHNYGWNGVGGFI 397
Cdd:cd17472 279 FAatSLWLLIIGLIIFFIGFNLLEALLPSLVSKIAPkEYRGTAMGIYNTSQFLGSFLGGALGGLLWGLLGYSSVFLTI 356
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
28-389 |
3.00e-14 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 73.73 E-value: 3.00e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 28 KRGTPQFIRVTLALFSAGLATFALLycvqPILPVLSSEFGVSPASSSISLSISTAMLAVGLLFTGPLSDAIGRKQVMVTA 107
Cdd:COG0738 4 KNYRRALIAIYLLFFLWGFATALWG----PLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 108 LVLASCCSLLSTMMSSWHGILMMRALIGLSLsGVAAVGMTYLSEEIHPSVVAFSMGLYISGNSIGGMSGRLLTGVFTDF- 186
Cdd:COG0738 80 LLLMALGLLLFALAPSYPLLLLALFLLGLGL-GLLDVAANPYVAALGPETAASRLNLLHAFFSLGALLGPLLGGLLILLg 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 187 --FGWRIALAVISGFALAAALMFWRI-LPESrhfRPTSLRPKSLLINFRLHWRDRGLPLLFLEGFLLMGSFVTLFNYIGY 263
Cdd:COG0738 159 lsLSWHLPYLILAVLLLLLALLFLRSkLPEI---EEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPL 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 264 RLMLS---PWSLSQAVVGLLSVAYLTGTWSspkAGAMTVRYGRGPVLLFSTAVMLGGLLLTLFSS-LWLIFIGMLLFSAG 339
Cdd:COG0738 236 YLKDVlglSEATAALGLSLFWGGMTIGRFL---GGFLLKRFGPVRLLRLSALLAAVGLLLALLAPgPWLALIGLALVGLG 312
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 503995541 340 FFAAHSVASSWIGPRARRARGQASSLYLFSYYLGSSMAGTLGGVFWHNYG 389
Cdd:COG0738 313 LSLMFPTIFSLALDGLGKRTAAAVSAVLIMGIVGGAIGPPLIGFLADAFG 362
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
36-211 |
1.66e-13 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 71.45 E-value: 1.66e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 36 RVTLALFSAGLATFALLYCVQPILPV-LSSEFGVSPASSSISLSISTAMLAVGLLFTGPLSDAIGRKQVMVTALVLASCC 114
Cdd:cd17325 199 RRLLALFLAIFVLAFAFGALEPFLPLyAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVA 278
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 115 SLLSTMMSSWHGILMMRALIGLSLSGVAAVGMTYLSEEIHPSVVAFSMGLYISGNSIGGMSGRLLTGVFTDFFGWRIALA 194
Cdd:cd17325 279 LLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFL 358
|
170
....*....|....*..
gi 503995541 195 VISGFALAAALMFWRIL 211
Cdd:cd17325 359 AAAALLLLAAVLFLLLR 375
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
37-384 |
2.22e-13 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 71.05 E-value: 2.22e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 37 VTLALFSAGLATFALLycvqPILPVLSSEFGVSPASSSISLSISTAMLAVGLLFTGPLSDAIGRKQVMVTALVLASCCSL 116
Cdd:cd17477 1 LLLSVALLGLGSGLLL----PLLSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 117 LSTMMSSWHGILMMRALIGLSLSGVAAVGMTYLSEEIHPSVVAFSMGLYISGNSIGGMSGRLLTGVFtDFFGWRIALAVI 196
Cdd:cd17477 77 LLALTDSPWVWFLLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLLLALV-GTAGALPFLIAA 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 197 SGFALAAALMFWRILPESRHFRPTSLRPKSLLinfrlhwrdRGLPLLFLEGF---LLMGSFVTLFNYIGYRLMLSpwslS 273
Cdd:cd17477 156 VLLLLALVPLLLTRRAAPEIEEAESISLRRLL---------RIAPLALLGAFvagFLEGAFYSLLPLYGLRLGLS----V 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 274 QAVVGLLSVAYLTGTWSSPKAGAMTVRYGRGPVLLFSTAVMLGGLLLTLF--SSLWLIFIGMLLFSAGFFAAHSVASSWI 351
Cdd:cd17477 223 AQAALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCALLGALAALLLPLvpGLPLALLVLLFLWGGAAGPLYTLALALA 302
|
330 340 350
....*....|....*....|....*....|....
gi 503995541 352 GPRARRA-RGQASSLYLFSYYLGSSMAGTLGGVF 384
Cdd:cd17477 303 GDRLPGDeLVAANAALLLLYGLGSVIGPLLAGAL 336
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
41-389 |
3.84e-13 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 70.32 E-value: 3.84e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 41 LFSAGLATFALLYCVQPILPVLSSEFGVSPASSSISLSISTAMLAVGLLFTGPLSDAIGRKQVMVTALVLASCCSLLSTM 120
Cdd:cd17489 1 ILLANFFFFLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 121 MSSWHGILMMRALIGLSLSGVAAVGMTYLSEEIHPSVVAFSMGLYISGNSIGGMSGRLLTGVFTDFFGWRIALAVISGFA 200
Cdd:cd17489 81 ATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 201 LAAALMFWRIlpesrhfRPTSLRPKSLLINFRLHWRDRGLPLLFLEGFLLMGSFVTlFNYIGYRLMLSPWSLSQAVVGLL 280
Cdd:cd17489 161 LLALLLVFLV-------KDPPPVAAEEAEAGTRAFRRLVEKKVLPPALILFLASIA-YGAISTFLPLYAAERGISNAGLF 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 281 SVAY-LTGTWSSPKAGAMTVRYGRGPVLLFSTAVMLGGLLLTLFS-SLWLIFIGMLLFSAGFFAAHSVASSWIGPRARRA 358
Cdd:cd17489 233 FTVYaIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAgSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPH 312
|
330 340 350
....*....|....*....|....*....|..
gi 503995541 359 -RGQASSLYLFSYYLGSSMAGTLGGVFWHNYG 389
Cdd:cd17489 313 rRGAANGTFFIFFDLGIGLGGLLLGLVAELFG 344
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
58-208 |
2.13e-12 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 68.00 E-value: 2.13e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 58 ILPVLSSEFGVSPASSSISLSISTAMLAVGLLFTGPLSDAIGRKQVMVTALVLASCCSLLSTMMSSWHGILMMRALIGLS 137
Cdd:cd17365 21 VAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGLG 100
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 503995541 138 LSGVAAVGMTYLSEEIHPSVVAFSMGLYISGNSIGGMSGRLLTGVFTDFFGWRIALAVISGFALAAALMFW 208
Cdd:cd17365 101 LGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGGVPPLILLPLLR 171
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
55-365 |
4.65e-12 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 66.88 E-value: 4.65e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 55 VQPILPVLSSEFGVSPASSSISLSISTAMLAVGLLFTGPLSDAIGRKQVMVTALVLASCCSLLSTMMSSWHGILMMRALI 134
Cdd:cd17475 15 IPALAPFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLV 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 135 GLSLSGVAAVGMTYLSEEIHPSVVAFSMGLYISGNSIGGMSGRLLTGVFTDFFGWRIALAVISGFALAAALMFWRILPES 214
Cdd:cd17475 95 GAGYGSVQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLVSILAAVLFWLFYREP 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 215 RHFRPTSLRPKSLLINFRLHWRDRGLPLLFLEGFLLMGS-FVTLFNYIGYRLMLSPWSLSQAVVgLLSVAYLTGTWSSPK 293
Cdd:cd17475 175 PAASAATESASTLLRSLKEVLRNRDVWLIAIAGALLVAPqFALLTFLLLFLHDHLGLSVVAAGA-LLAVAQLGGALGRIG 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 294 AGAMTVRYGRG---PVLLFSTAVMLGGLLLTLF----SSLWLIFIGMLLFSAGFFAAHSVASSWIGPRA-RRARGQASSL 365
Cdd:cd17475 254 LGRVSDRVFGGrrrPVLVITAAIAAAALLVLSLlspgTPLWLLVLLLILLGLFAIGWNGLYLTLVAESAgPEQAGTALGL 333
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
38-351 |
4.97e-12 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 66.86 E-value: 4.97e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 38 TLALFSAGLATFALLYCVQPILPVLSSEF--GVSPASSSISLSISTAMLAVGLLFTGPLSDAIGRKQVMVTALVLASCCS 115
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEFslGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLAT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 116 LLSTMMSSWHGILMMRALIGLSLSGVAAVGMTYLSEEIHPSVVAFSMGLYISGNSIGGMSGRLLTGVFTDFF----GWRI 191
Cdd:cd17316 81 LLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLsgdwGWRI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 192 ALAVISGFALAAALMFWRILpesrhfrptslrpksllinfrlhwrdrglpLLFLEGFLLMGSFVTLFNYIGYRLMLSPWS 271
Cdd:cd17316 161 LFLIGALPALLALLLRRRTL------------------------------LLILLWFFISFGYYGLTTFLPTYLQTVLGL 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 272 LSQAVVGLLSVAYLTGTWSSPKAGAMTVRYGRGPVLLFS---TAVMLGGLLLTLFSSLWLIFIGMLLFSAGFFAAHSVAS 348
Cdd:cd17316 211 SPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGlilSGILALPLFYLLSGSPTLLLLLLFILSFFVGGVWGALY 290
|
...
gi 503995541 349 SWI 351
Cdd:cd17316 291 AYL 293
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
34-389 |
1.22e-11 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 65.76 E-value: 1.22e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 34 FIRVTLALFSAGLATFALLYCVQPILPVLSSEFGVSPASSSISLSISTAMLAVGLLFTGPLSDAIGRKQVMVT-ALVLAS 112
Cdd:cd17355 1 GWVVLAVTFLILILSWGIRYYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLgLLLLAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 113 CCSLLSTMMSSWHGILMMRALIGLSLSGVAAVGMTYLSEEIHPSVVAFSMGLYISGNSIGGMSGRLLTGVFTDFFGWRIA 192
Cdd:cd17355 81 GLVLLALATSLWQLYLLWGLLGGGGAGTLAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 193 LAVISGFALA----AALMFWRILPESRHFRPTSLRPKSLLINFRLHWRDRGLPLL----FLEGFLLMGSFVTLFNYIGYR 264
Cdd:cd17355 161 LLVLALLALLvlvpVLLLLRRRPADLALRAYDDASPASPGSTLKEALRSASFWLLalafFLCGFAVVGLIVHLVPYLADR 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 265 LMlsPWSLSQAVVGLLSVAYLTGTWSSpkaGAMTVRYGRGPVL---LFSTAVMLGGLLLTLFSSLWLIFIGMLLfsaGFF 341
Cdd:cd17355 241 GI--SPAAAAVALALIGLFNIVGRLLS---GWLGDRYSPRRLLaasYALRALGLALLLLLPFPPLALLLFAALF---GLG 312
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 503995541 342 AAHSVASSWIGPRARRARGQASSLY---LFSYYLGSSMAGTLGGVFWHNYG 389
Cdd:cd17355 313 WGATVPLTAALAARYFGARSYGTLFglvFAPHQLGSALGPWLGGLLYDRTG 363
|
|
| PRK11102 |
PRK11102 |
Bcr/CflA family multidrug efflux MFS transporter; |
57-262 |
2.72e-11 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182964 [Multi-domain] Cd Length: 377 Bit Score: 64.55 E-value: 2.72e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 57 PILPVLSSEFGVSPASSSISLSISTAMLAVGLLFTGPLSDAIGRKQVMVTALVLASCCSLLSTMMSSWHGILMMRALIGL 136
Cdd:PRK11102 12 PALPVIAADFGVSAGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFLHGL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 137 SLSGVAAVGMTYLSEEIHPSVVAFSMGLYISGNSIGGMSGRLLTGVFTDFFGWRIALAVISGFALAAALMFWRILPES-R 215
Cdd:PRK11102 92 AAAAASVVINALMRDMFPKEEFSRMMSFVTLVMTIAPLLAPIIGGWLLVWFSWHAIFWVLALAAILAAALVFFFIPETlP 171
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 503995541 216 HFRPTSLRPKSLLINFRLHWRD-RGLPLLFLEGFLLMGSFVTL----FNYIG 262
Cdd:PRK11102 172 KERRQPFHLRTTIRNFASLFRHkRVLGYMLASGFSFAGMFSFLtagpFVYIE 223
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
38-215 |
5.27e-11 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 63.74 E-value: 5.27e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 38 TLALFSAGLATFALLYCVQPILPV-LSSEFGVSPASSSISLSISTAMLAVGLLFTGPLSDAIGR--KQVMVTALVLASCC 114
Cdd:COG2271 182 FWLLALAYFLVYFALYGFLTWLPTyLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRrrKLVLAIGLLLAALA 261
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 115 SLLSTMMSSWHGILMMRALIGLSLSGVAAVGMTYLSEEIHPSVVAFSMGLYISGNSIGGMSGRLLTGVFTDFFGWRIALA 194
Cdd:COG2271 262 LLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFL 341
|
170 180
....*....|....*....|.
gi 503995541 195 VISGFALAAALMFWRILPESR 215
Cdd:COG2271 342 LLAALALLAALLALLLLRETR 362
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
57-373 |
8.24e-11 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 62.98 E-value: 8.24e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 57 PILPVLSSEF-GVSPASSSISLSISTAMLAVGLLFTGPLSDAIGRKQVMVTALVLASCCSLLSTMMSSWHGILMMRALIG 135
Cdd:cd17473 20 PALPAIAQHFvPNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLG 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 136 LSLSGVAAVGMTYLSEEIHPSVVAFSMGLYISGNSIGGMSGRLLTGVFTDfFGWRIALAVIsGFALAAALMFWRILPESR 215
Cdd:cd17473 100 IGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAE-IGWRAPFLVY-LLALPVLILVLLFLPEPA 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 216 HFRPTSLRPKSLLiNFRLHWRdRGLPLLFLeGFLLMGSFVTLFNYIGYrLMLSPWSLSQAVVGL-LSVAYLTGTWSSPKA 294
Cdd:cd17473 178 RKSKSAASPGAAT-AAALPWK-RVLPIYFL-AFLAMLLFYVIPIQLPF-LLQERGGGSAALIGLaLAIASLAGAIGALLF 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 295 GAMTVRYGRGPVLLFSTAVM-LGGLLLTLFSSLWLIFIGMLLFSAGFFAAHSVASSWIGPRA-RRARGQASSLYLFSYYL 372
Cdd:cd17473 254 GRLKRRLGKRRLLAIGFALMaLGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVpPELRGRAMGIVTSAFFL 333
|
.
gi 503995541 373 G 373
Cdd:cd17473 334 G 334
|
|
| MFS_KgtP |
cd17367 |
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ... |
83-321 |
1.49e-10 |
|
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 62.31 E-value: 1.49e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 83 MLAVGLLFTGPLSDAIGRKQVMVTALVLASCCSLLSTMMSSWHGI--------LMMRALIGLSLSGVAAVGMTYLSEEIH 154
Cdd:cd17367 52 MRPIGGWLFGRLADRIGRRAALTLSVSLMAAGSLVIAVTPTYATIgiwapiilLLARLLQGLSVGGEYGTSATYLSEVAP 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 155 PSVVAF-SMGLYIS---GNSIGGMSGRLLTGVFTD----FFGWRIALAVISGFALAAALMfWRILPESRHFRPTSLRPK- 225
Cdd:cd17367 132 PGRRGFySSFQYVTligGQLLALGVLLVLQHTLGEdqmaAWGWRIPFLLGGVLAVVVLWL-RRGLEETESFEAIAESNEa 210
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 226 --SLLINFRLHWRdrglPLLFLEGFLLMGSF------VTLFNYIGYRLMLSPWSLSQAVVGLLSVAYLTgtwsSPKAGAM 297
Cdd:cd17367 211 saGTLRELRRHPR----ELLLVVGLTAGGTLafytwtTYLQKFLVNTAGFSKGDATWITTAALLVFMLL----QPLGGRL 282
|
250 260
....*....|....*....|....
gi 503995541 298 TVRYGRGPVLLFSTavmLGGLLLT 321
Cdd:cd17367 283 SDRIGRRPLLLFFG---IGGTLAT 303
|
|
| efflux_Bcr_CflA |
TIGR00710 |
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
57-380 |
5.26e-10 |
|
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.
Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 60.86 E-value: 5.26e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 57 PILPVLSSEFGVSPASSSISLSISTAMLAVGLLFTGPLSDAIGRKQVMVTALVLASCCSLLSTMMSSWHGILMMRALIGL 136
Cdd:TIGR00710 26 PAFPEIAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSLGLALSNNIETLLVLRFVQAF 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 137 SLSGVAAVGMTYLSEEIHPSVVAFSMGLYISGNSIGGMSGRLLTGVFTDFFGWRIALAVISGFALAAALMFWRILPESRH 216
Cdd:TIGR00710 106 GASAGSVISQALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVWLSWHAIFAFLSLAGILLSALIFFILPETLP 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 217 FRPTSLRPKSLLiNFRLHWRDRGLPLLFLEGFLLMGSFVTLFNyIGYRLMLSPWSLSQAVVGLL----SVAYLTGTWSSP 292
Cdd:TIGR00710 186 YEARIQISTYFE-TFLLLLKSKMFWGYALIYGASFGGFFAFFS-GAPFVYIDIMGVSPSVFGLLfalnIIAMIFGGFLNG 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 293 KAGAMTVRYGRGPVLLFSTAVMLGGLLLTLFSSL--WLIFIG-MLLFSAGFFAAHSVASSWIGPRARRARGQASSLYLFS 369
Cdd:TIGR00710 264 RFIKKWGAKSLLRMGLILFAVSAVLLEITAILGLgsWAMIIGpMMFVGIGNSMISSIAMAYALEDFPHVAGTASALFGTL 343
|
330
....*....|.
gi 503995541 370 YYLGSSMAGTL 380
Cdd:TIGR00710 344 RLVLGAIVGYL 354
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
58-362 |
8.59e-10 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 60.01 E-value: 8.59e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 58 ILPVLSSEFGVSPASSSISLSISTAMLAVGLLFTGPLSDAIGRKQVMVTALVLASCCSLLSTMMSSWHGILMMRALIGLS 137
Cdd:cd17371 21 VLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRALAGLG 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 138 LSGVAAVGMTYLSEEIHPSVVAFSMGLYISGNSIGGMSGRLLT----GVFTDFFGWRiALAVISGFALAAALMFWRILPE 213
Cdd:cd17371 101 FGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAallfPLLPPEIAWR-VLFLLGALPALLVLFIRRFVKE 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 214 S------RHFRPTSLRPKSLLINFRLHWRDRGLPLLFLEGFLLMGSFVTLF---NYIGYRLMLSPWSLSQAVVGLLSVAY 284
Cdd:cd17371 180 PpqwqaaRAARRHFADRPSLRELFSPPLLRTTLLASLLATGALGGYYGITTwlpSYLTGERGLSFEGSAGYLVVTILGGF 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 285 LtGTWSspkAGAMTVRYGRGPVLLFSTAVMLGGLLLTLFSS------LWLIFIGmLLFSAGFFAAHSVASSWIGPRARRA 358
Cdd:cd17371 260 L-GYLA---GGFLADRIGRRNNFALFALGSAISILLYFFLPlsptliLILGFPL-GFFASGPFSGMGAYLTELFPTAVRA 334
|
....
gi 503995541 359 RGQA 362
Cdd:cd17371 335 TAQG 338
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
57-396 |
2.16e-09 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 58.71 E-value: 2.16e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 57 PILPVLSSEFGVSPASSSISLSISTAMLAVGLLFTGPLSDAIG-RKQVMVTALVLASCCSLLSTMMSSWHGILMMRALIG 135
Cdd:cd17370 20 SILPLFLVVLGASAAAVGLIEGLAEALGSLLRLFSGYLSDRTGkRKPLVILGYGLSALAKPLLALAGSWQLVLLLRILER 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 136 LSLSGVAAVGMTYLSEEIHPSVVAFSMGLYISGNSIGGMSGRLLTGVFTDFFG----WRIALAVISGFALAAALMFWRIL 211
Cdd:cd17370 100 LGKGIRTPPRDALLADATPPSGRGKAFGLHRALDTLGAVLGPLLAALLLYLLGgnyrTIFLLAAIPALLALLILLFVVKE 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 212 PESRHFRPTSLRPKSLLINFRLHWRdrglpllflegFLLMGSFVTLFNY----IGYRLMLSPWSLSQAVVgLLSVAYLTG 287
Cdd:cd17370 180 YPRPPKLRKKSKKTSLKKLPKAFWL-----------YLLAVALFALGNFsfafLILRAQELGLSAALIPL-LYALFNLVY 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 288 TWSSPKAGAMTVRYGRGPVLLFSTAVMLGG-LLLTLFSSLWLIFIGMLLFSAGFFAAHSVASSWIGPRAR-RARGQASSL 365
Cdd:cd17370 248 ALAAYPAGRLSDRIGRKKLLILGYLSLALAyLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPaELRGTAYGL 327
|
330 340 350
....*....|....*....|....*....|.
gi 503995541 366 YLFSYYLGSSMAGTLGGVFWHNYGWNGVGGF 396
Cdd:cd17370 328 FNTVVGIGWLLASLIAGYLWDLISPSAAFLF 358
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
59-391 |
5.33e-09 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 57.59 E-value: 5.33e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 59 LPVLSSEFGVSPASSSISLSISTAMLAVGLLFTGPLSDAIGRKQVMVTALVLASCCSLLSTMMSSWHGILMMRALIGLSL 138
Cdd:cd17503 19 LPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQGFGG 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 139 SGVAAVGMTYLSEEIHPSVVAFSMGLYISGNSIGGMSGRLLTGVFTDFFGWRIALAVISGFALAAALMfwriLPesrhfr 218
Cdd:cd17503 99 GVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIGILALLL----AP------ 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 219 ptslrpkslLINFRLhWRDR----GLPLLFLEGFLLMGSFVT----LFNYIGYR-----LMLSPWSLSQAVvgllsvayl 285
Cdd:cd17503 169 ---------LLDLRL-FKDRnftlGLLLSFLLGLGLFGAMFLlplyLQNVLGYSafesgLVLAPGGLASAI--------- 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 286 tgtwSSPKAGAMTVRYGRGPVLLFSTAVMLGGLLLTLF----SSLWLIFIGMLLFSAGFFAAHSVASSW-IGPRARRARG 360
Cdd:cd17503 230 ----LSPLVGRLLDKFGPRLLLLAGLLLLALGTLLLAFltpdTSLWLIILPLFIRGLGMGLVFMPLNTLaLNSLPPEQIG 305
|
330 340 350
....*....|....*....|....*....|.
gi 503995541 361 QASSLYLFSYYLGSSMAGTLGGVFWHNYGWN 391
Cdd:cd17503 306 DATALFNTIRQLGGSIGTALLATLLTNRTQF 336
|
|
| PRK15402 |
PRK15402 |
MdfA family multidrug efflux MFS transporter; |
55-327 |
7.17e-09 |
|
MdfA family multidrug efflux MFS transporter;
Pssm-ID: 185300 [Multi-domain] Cd Length: 406 Bit Score: 57.26 E-value: 7.17e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 55 VQPILPVLSSEFGVSPASSSISLsisTAMLAVGLLF---TGPLSDAIGRKQVMVTALVLASCCSLLSTMMSSWHGILMMR 131
Cdd:PRK15402 32 IQPGMLAVVEDFNAGAEWVPTSM---TAYLAGGMFLqwlLGPLSDRIGRRPVMLAGVAFFILTCLAILLAQSIEQFTLLR 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 132 ALIGLSLSGVAAVGMTYLSEEIHPSVVAFSMGLYISGNSIGGMSGRLLTGVFTDFFGWRIALAVISGFALAAALMFWRIL 211
Cdd:PRK15402 109 FLQGIGLCFIGAVGYAAIQESFEEADAIKITALMANVALLAPLLGPLVGAALIHVLPWRGMFVLFAALAALSFFGLWRAM 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 212 PESRHFRPTSLRPKSLLINFRLHWRDRGlpllFLEGFLLMGsFVT--LFNYIGyrlmLSPWSLSQAvVGLLSVAYltGTW 289
Cdd:PRK15402 189 PETAGRVGEKLSLKELGRDYKLVLKNRR----FVAGALALG-LVSlpLLAWIA----LSPVILISG-EQLSSYEY--GLL 256
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 503995541 290 SSPKAGAM----------TVRYGRGPVLLFSTAVMLGGLLLTLFSSLW 327
Cdd:PRK15402 257 QVPVFGALiagnltlarlTSRRPLRSLIRMGLWPMVAGLLLAALATVI 304
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
82-214 |
1.91e-08 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 52.65 E-value: 1.91e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 82 AMLAVGLLFTGPLS----DAIGRKQVMVTALVLASCCSLLSTMMSSWHGILMMRALIGLSLSGVAAVGMTYLSEEIHPSV 157
Cdd:TIGR00880 5 AGYALGQLIYSPLSglltDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIYPPEE 84
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 503995541 158 VAFSMGLYISGNSIGGMSGRLLTGVFTDFFGWRIALAVISGFALAAALMFWRILPES 214
Cdd:TIGR00880 85 RGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLPET 141
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
58-384 |
2.41e-08 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 55.27 E-value: 2.41e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 58 ILPVLSSEFGVSPASSSISLSISTAMLAVGLLFTGPLSDAIGRKQVMVTALVLASCCSLLSTMMSSWHGILMMRALIGLS 137
Cdd:cd17319 25 AAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGVA 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 138 LSGVAAVGMTYLSEEIHPSVVAFSMGLYISGNSIGGMSGRLLTGVFTDFFGWRIALAVISGFALAAALMFWRILPESrhf 217
Cdd:cd17319 105 EAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLLAVLWWFYLRQV--- 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 218 rptslrpksllinfrlhwrdrglpLLFLEGFLLMGSFVTLFNYIGYRLMLSPWSLSQAVVGLLS----VAYLTGTWSSPK 293
Cdd:cd17319 182 ------------------------WGLALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAaipfLAGAIGMILGGR 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 294 AGAMTVRYGRGPVLLFSTAVMLGGLLL-TLFSSLWLIFIGMLLFSAGFFAAHSVASSWIGPRA-RRARGQASSLYLFSYY 371
Cdd:cd17319 238 LSDRLLRGARRLVIIIGLLLAAVGLLLaYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLpGEAAATAGGLINSGGN 317
|
330
....*....|...
gi 503995541 372 LGSSMAGTLGGVF 384
Cdd:cd17319 318 LGGFVAPLLIGYL 330
|
|
| PRK03893 |
PRK03893 |
putative sialic acid transporter; Provisional |
58-218 |
7.64e-08 |
|
putative sialic acid transporter; Provisional
Pssm-ID: 179668 [Multi-domain] Cd Length: 496 Bit Score: 54.32 E-value: 7.64e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 58 ILPVLSSEFGVSPASSSISLSISTAMLAVGLLFTGPLSDAIGRKQVMVTALVLASCCSLLSTMMSSWHGILMMRALIGLS 137
Cdd:PRK03893 42 VLTEVQGEFGLTTVQAASLISAAFISRWFGGLLLGAMGDRYGRRLAMVISIVLFSVGTLACGFAPGYWTLFIARLVIGMG 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 138 LSGVAAVGMTYLSEEIHPSVVAFSMGLYISGNSIGGMSGRLLTGVFTDFFGWRiALAVISGFALAAALMFWRILPESRHF 217
Cdd:PRK03893 122 MAGEYGSSATYVIESWPKHLRNKASGFLISGFSIGAVVAAQVYSLVVPVWGWR-ALFFIGILPIIFALWLRKNLPEAEDW 200
|
.
gi 503995541 218 R 218
Cdd:PRK03893 201 K 201
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
36-391 |
1.20e-07 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 53.37 E-value: 1.20e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 36 RVTLALFSAGLATFALLYcVQPILPVLSSEFGVSPASSSISLSISTAMLAVGLLFTGPLSDAIGRKQ------VMVTALV 109
Cdd:COG2211 12 KLAYGLGDLGLNLAFGLL-SAYLLYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDRTRTRWgrrrpwILIGAIP 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 110 LASCCSLLSTMMSSWHGILMMRALIGLSLSGVA--AVGMTYLS--------EEIHPSVVAFSMGLYISGNSIGGMSGRLL 179
Cdd:COG2211 91 LALSFVLLFTAPDLSPTGKLIYALVTYLLLGLAytLVNIPYSAlgaeltpdYEERTRLSSWRFAFAGLGGLLASVLPPPL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 180 TGVF--TDFFGWRIALAVISGFALAAALMFWRILPESRHFRPTslrPKSLLINFRLHWRDRGLPLLFLeGFLLMGSFVTL 257
Cdd:COG2211 171 VAAFggDAALGYRLTALIFAVLGLLAFLLTFFGTKERPVPEEE---KVSLKESLKALLKNRPFLLLLL-AYLLFFLALAL 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 258 FNYIGYRLMLSPWSLSQAVVGLLSVAY-LTGTWSSPKAGAMTVRYGRGPVLLFSTAVMLGGLLLTLF---SSLWLIFIGM 333
Cdd:COG2211 247 VAALLLYYFKYVLGLSAALVGLLLALYfLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFlgpGNLWLLLVLA 326
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 503995541 334 LLFSAGFFAAHSVASSWIGPRA--------RRARGQASSLYLFSYYLGSSMAGTLGGVFWHNYGWN 391
Cdd:COG2211 327 ALAGIGLGAILVLPWAMLADVVdydewktgRRREGLYFGIFTFAIKLGQALAGALAGLLLALFGYV 392
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
59-393 |
1.79e-07 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 52.66 E-value: 1.79e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 59 LPVLSSEFGVSPASSSISLSISTAMLAVGLLFTGPLSDAIGRKQVMVTALVLASCCSLLSTMMSSWHGILMMRALIGLSL 138
Cdd:cd17312 26 KPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWFFAVLWGLNGLFQ 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 139 SGVAAVGMTYLSEEIHPSVVAFSMGLYISGNSIGGMSGRLLTGVFTDFFGWRIALAVISGFALAAALMFWrilpesrhfr 218
Cdd:cd17312 106 SMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAFLVPGIVGLVVAIILF---------- 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 219 ptslrpksllinFRLHWRDRGLPLLFLEGFLLMGS-FVTLFNYIGYRLMLSPWSLSQA--VVGLLSVAYLTGTWSSPKAG 295
Cdd:cd17312 176 ------------FFLRDSPPYVWVLSLAYAFVYIVrYACLDWGPLYLYEVKGYSLIDAgwFSSLYEVGGIAGTILAGLLS 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 296 AMTVRYGRGPVLLFSTAVMLGGLLLTLFSSLWLIFIGMLLFSAGFFAAHSV------ASSWIGPraRRARGQASSLYLFS 369
Cdd:cd17312 244 DKLFGGRRAPIAVIYMLLMTLSLALFWFFPHNKLLSIVLLFLIGFFVGGPInliggaAAQDIGR--KEAAGTATGFVGLF 321
|
330 340
....*....|....*....|....
gi 503995541 370 YYLGSSMAGTLGGVFWHNYGWNGV 393
Cdd:cd17312 322 GYLGASLAGLPLGYIIDHYGWSTV 345
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
85-217 |
3.33e-07 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 52.27 E-value: 3.33e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 85 AVGLLFTGPLSDAIGRKQVMVTALVL---ASCCSLLSTMMSSWHGILMMRALIGLSLSGVAAVGMTYLSEEIHPSVVAFS 161
Cdd:pfam00083 60 FIGSLFAGKLGDRFGRKKSLLIANVLfviGAVLQGAAKGKWSVYQLIVGRVLVGIGVGGASVLAPMYISEIAPKKLRGAL 139
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 162 MGLYISGNSIGGMSGR---LLTGVFTDFFGWRIALAVISGFALA-AALMFWriLPESRHF 217
Cdd:pfam00083 140 GSLYQLAITFGILLAYifgLGLNKTSNSDGWRIPLGLQLVPALLlIIGLLF--LPESPRW 197
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
89-393 |
3.92e-07 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 51.85 E-value: 3.92e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 89 LFTGPLSDAIGRKQVMVTALVLASCCSLLSTMMSSWHGILMMRALIGLSLSGVAA-----VGMTYLSEEIHPSVVAFSMG 163
Cdd:cd06173 52 PFAGVLADRFDRRRLLILADLLRALLAAVLALLALLGSLSLWLLLVLAFLLGIASaffgpARQALLPELVPKEQLVRANA 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 164 LYISGNSIGGMSGRLLTGVFTDFFG--WRIALAVISGFALAAALMFWRILPESRHFRPTSLRPKSLLINFRLHWRDRGLP 241
Cdd:cd06173 132 LNSLATQLARIIGPALGGLLVALLGpgGAFAINALSFLLSALLLLFIRRPPPAAPGESSSLLLRDLREGLRYLRRSPLLR 211
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 242 LLFLEG---FLLMGSFVTLFNYIGYR-LMLSPWSLSQAV----VGLLSVAYLTGTWSSpkagamtvRYGRGPVLLFSTAV 313
Cdd:cd06173 212 LLLLALalfALLGGALTVLLPLLAKEvLGGGAAGYGLLLaafgVGALLGALLLGRLSK--------RRRRGRLLLIGALL 283
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 314 M-LGGLLLTLFSSLWLIFIGMLLFSAGFFAAHSVASSWIGPRARRA-RGQASSLYLFSYYLGSSMAGTLGGVFWHNYGWN 391
Cdd:cd06173 284 LgLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDElRGRVFSVYNALNSGAMPLGALLAGLLADALGLS 363
|
..
gi 503995541 392 GV 393
Cdd:cd06173 364 AV 365
|
|
| MFS_CitA |
cd17368 |
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton ... |
83-360 |
4.28e-07 |
|
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton symporter, also called citrate carrier protein or citrate transporter or citrate utilization protein A (CitA), is a proton symporter that functions in the uptake of citrate across the boundary membrane. It allows the utilization of citrate as a sole source of carbon and energy. In Klebsiella pneumoniae, the gene encoding this protein is called citH, instead of citA, which is the case for Escherichia coli and other organisms. CitA belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340926 [Multi-domain] Cd Length: 407 Bit Score: 51.61 E-value: 4.28e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 83 MLAVGLLFTGPLSDAIGRKQVMVTALVLASCCSLLSTMMSSWHGI--------LMMRALIGLSLSGVAAVGMTYLSEEIH 154
Cdd:cd17368 52 MRPIGAIVLGAYADRIGRKPAMTLTLAIMALGTLLIALAPTYATIgiaapllvLLARLLQGFAAGGEVGGVTAYLVEAAP 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 155 PSVVAFSMGLYISG----NSIGGMSGRLLTGVFT----DFFGWRIALAVisgFALAAALMFW--RILPESRHFRPTSLRP 224
Cdd:cd17368 132 PGRRGFYTSWQSASqqvaIVAGALVGYLLSLTLTaealAEWGWRIPFFI---GLLIIPLGLWlrRSLEETEAFLERKARP 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 225 --KSLLINFRLHWRdrglplLFLEGFLLMGS-----FVTLFNYIGYRLMLSPWSLSQAVVGLLsVAYLTGTWSSPKAGAM 297
Cdd:cd17368 209 trRELFALLANNRR------IILLGMLLVAGstvtfYFTTVYTPTYAKTVLGLSARDSFLVTL-LAGVANFIWAPLGGAL 281
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 503995541 298 TVRYGRGPVLLFSTAvmlgGLLLTLFSSLWLIF----IGMLL--------FSAGFFAAHSVASSWIGPRARRARG 360
Cdd:cd17368 282 SDRIGRRPVLLVITL----AALVTLYPVFAWLTaapsFGRLLlvllvlsfFFGMYGGAMVVALVELFPVRVRSTG 352
|
|
| MFS_TetA |
cd17388 |
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ... |
34-339 |
1.27e-06 |
|
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 50.33 E-value: 1.27e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 34 FIRVTLALFSAGLATfallycVQPILPVLSSEFGVSPASSSISLSISTAMLAVGLLFTGP----LSDAIGRKQVMVTALV 109
Cdd:cd17388 3 FILVTVLLDAMGIGL------IMPVLPTLLREFVGDSADAATHYGVLLALYALMQFIFAPilgaLSDRFGRRPVLLLSLA 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 110 LASCCSLLSTMMSSWHGILMMRALIGLSlSGVAAVGMTYLSEEIHPSVVAFSMGLYISGNSIGGMSGRLLTGVFTDFfGW 189
Cdd:cd17388 77 GAALDYLLMAFAPTLWWLYLGRIIAGIT-GATGAVAAAYIADVTPPEQRARNFGLLGAAFGLGFIAGPALGGLLGEI-SP 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 190 RIALAVISGFALAAALMFWRILPESRHFRPTSLRPKSLLINFRLHWRDRGLPL---LFLEGFLLMGS----FVTLFNYIG 262
Cdd:cd17388 155 RAPFLVAAGLNGLNFLLGLFVLPESLPPERRRAFRWRRANPFGSLRWLTGFPGllgLLAVFFLIQLIgqvpATTWVLFTE 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 263 YRLMLSPWS--LSQAVVGLLSV---AYLTGtWSSPKAGAmtvrygRGPVLLFSTAVMLGGLLLTLFSSLWLIFIGMLLFS 337
Cdd:cd17388 235 DRFDWSPTMvgLSLAVFGLLHAlfqAFVTG-PIAKRLGE------KRAILLGLAADALGFLLLAFATQGWMVFPILILLA 307
|
..
gi 503995541 338 AG 339
Cdd:cd17388 308 LG 309
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
60-221 |
2.60e-06 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 49.19 E-value: 2.60e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 60 PVLSSEFGVSPASSSISLSISTAMLAVGLLFTGPLSDAIGRKQVMVTALVLASCCSLLSTMMSSWHGILMMRALIGLSLS 139
Cdd:PRK11551 39 PRMAQEFGLDVAQMGWAFSAGILGLLPGALLGGRLADRIGRKRILIVSVALFGLFSLATAQAWDFPSLLVARLLTGVGLG 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 140 GVAAVGMTYLSEEIHPSVVAFSMGLYISGNSIGGMSGRLLTGVFTDFFGWRIALaVISGFA-LAAALMFWRILPESRHFR 218
Cdd:PRK11551 119 GALPNLIALTSEAVGPRLRGTAVSLMYCGVPFGGALASVIGVLAAGDAAWRHIF-YVGGVGpLLLVPLLMRWLPESRAFA 197
|
...
gi 503995541 219 PTS 221
Cdd:PRK11551 198 QAA 200
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
57-211 |
3.54e-06 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 48.73 E-value: 3.54e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 57 PILPVLSSEFGVSPASSSISLSISTAMLAVGLLFTGPLSDAIGRKQVMVTALVLASCCSLLSTMMSSWHGILMMRALIGL 136
Cdd:cd17323 20 PALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNIAMLIILRFLQGF 99
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 503995541 137 SLSGVAAVGMTYLSEEIHPSVVAFSMGLYISGNSIGGMSGRLLTGVFTDFFGWR---IALAVISGFALAAALMFWRIL 211
Cdd:cd17323 100 FGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRwifWFLAIISGFCLILIFLFLPIV 177
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
85-215 |
3.70e-06 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 48.72 E-value: 3.70e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 85 AVGLLFTGPLSDAIGRKQVMVTALVLASCCSLLSTMMSSWHGILMMRALIGLSLSGVAAVGMTYLSEEIHPSVvafsMGL 164
Cdd:cd17315 48 AIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWVLIVGRFLLGLGVGLASVLVPLYISEIAPAKI----RGA 123
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 503995541 165 YISGNSIGGMSGRLLTGVFTDFF------GWRIALAVISGFALAAALMfWRILPESR 215
Cdd:cd17315 124 LGTLNQLMITFGILLAYLLGLALslsppgWWRLMFALAAVPALLQLLL-MFFLPESR 179
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
41-215 |
4.39e-06 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 48.39 E-value: 4.39e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 41 LFSAGLATFALLYCVQPILPVLSSEFGVSPASSSISLSISTAMLAVGLLFTGPLSDAIGRKQVMVTALVLASCCSLLSTM 120
Cdd:cd17328 4 LFLINLLNYMDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSF 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 121 MSSWHGILMMRALIGLSLSGVAAVGMTYLSEEIHPSVVAFSMGLYISGNSIGGMSGRLLTGVFTDFF-GWRIALAVISGF 199
Cdd:cd17328 84 APNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATgGWRWAFRVTGVL 163
|
170
....*....|....*.
gi 503995541 200 ALAAALMFWRILPESR 215
Cdd:cd17328 164 GVLLAILLLLFVREPP 179
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
32-173 |
4.72e-06 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 48.43 E-value: 4.72e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 32 PQFIRVTLALFSAGLATFALLYCVQPIlpvLSSEFGVSPASSSISLSISTAMLAVGLLFTGPLSDAIGRKQVMVTALVLA 111
Cdd:COG2814 207 PRLLLLLLLAFLLGFGFFALFTYLPLY---LQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLL 283
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 503995541 112 SCCSLLSTMMSSWHGILMMRALIGLSLSGVAAVGMTYLSEEIHPSVVAFSMGLYISGNSIGG 173
Cdd:COG2814 284 ALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGG 345
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
38-384 |
5.77e-06 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 48.02 E-value: 5.77e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 38 TLALFSAGLATFALlycvQPILPVLSSEFGVSPASSSISLSISTAMLAVGLLFTGPLSDAIGRKQVMVTALVLASCCSLL 117
Cdd:cd17341 5 WLSFFLGFMVWFLF----APLGPVIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIPLLA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 118 STM-MSSWHGILMMRALIGLSLsGVAAVGMTYLSEEIHPSVVA-FSMGLYISGNSIGGMSGRLLTGVF------TDFFGW 189
Cdd:cd17341 81 LALaVSSYWGLLVLGFLLGFAG-ANFASGQPWASFWFPKEKIGgAAGGIAGAGNMGVAVSQLLAPLIAgaivfdGGFVGW 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 190 RIALAVISGFALAAALMFW---RILPESRHFRPTSLRPKSLLINFRLHWrdrglpLLFLEGFLLMGSFVTLFNYIGyRLM 266
Cdd:cd17341 160 RNAFFVPGILLAIAAVLVLlfgDDLPTGKASALEFLKVQLAVLKNYRTW------ILSLLYGVTFGSFVGFSNVLP-TYF 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 267 LSPWSLSQAVVGLLSVAY-LTGTWSSPKAGAMTVRYGRGPVLLFSTAVMLGGLLLTLFS------SLWLIFIGMLLFSAG 339
Cdd:cd17341 233 KTRFGLPLVTAGILAALFpLAGALARPAGGWLSDRFGGRRRLWWLFIVMTIGAALLSLSlptsgtNLVLFLALFVALGLG 312
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 503995541 340 FFAAHSVASSWIGPRARRARGQASSLylfsyylgSSMAGTLGGVF 384
Cdd:cd17341 313 AGAGNGSVFRMVPFIFRRELGAVTGL--------VGAIGGLGGFF 349
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
37-346 |
7.36e-06 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 47.55 E-value: 7.36e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 37 VTLALFSAGLATFALLYCVQPILPVLSSEFGVSPASSSISLSISTAMLAVGLLFTGPLSDAIGRKQVMVTALVLASCCSL 116
Cdd:cd17352 4 VVFASFLVNFFTDGILNSFGVLFVELLEEFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAALGLL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 117 LSTMMSS-WHGILMMRALIGLSLsgvaavGMTYLseeihPSVVAFS----------MGLYISGNSIGGMSGRLLTGVFTD 185
Cdd:cd17352 84 LSSFATSlWQLYLTYGVLGGLGL------GLIYS-----PAIVIVGqyfekkrglaTGIAVAGSGVGTFVFPPLLRYLLD 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 186 FFGWRIALAVISGFALAAALMfwrilpesrhfrptslrpkSLLINFrlhWRDRGLPLLFLEGFLLMGSFVTLFNYIGYRL 265
Cdd:cd17352 153 NYGWRGALLILGGLCLNLCVC-------------------GLLLRL---LKDPTFVLLALGVSFAMLGFFVPFVYLPSYA 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 266 MLSPWSLSQAVVgLLSVAYLTGTWSSPKAGAMTVRYGRGPVLLFSTAVMLGGLLLTL------FSSLWLIFIGMLLFSAG 339
Cdd:cd17352 211 KSLGIDESDAAF-LLSIIGISDIVGRILLGLLADKPRIGRLYLYIFTLLILGLSLLAfplattYVGLIVFSVLFGFCSGS 289
|
....*..
gi 503995541 340 FFAAHSV 346
Cdd:cd17352 290 YSSLTPV 296
|
|
| emrD |
PRK11652 |
multidrug transporter EmrD; |
57-289 |
7.87e-06 |
|
multidrug transporter EmrD;
Pssm-ID: 183259 [Multi-domain] Cd Length: 394 Bit Score: 47.59 E-value: 7.87e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 57 PILPVLSSEFGVSPASSSISLSIStaMLAVGL--LFTGPLSDAIGRKQVMVTALVLASCCSLLSTMMSSWHGILMMRALI 134
Cdd:PRK11652 29 PAIADMARDLNVREGAVQAVMAAY--LLTYGLsqLFYGPLSDRVGRRPVILVGMSIFILGTLVALFAHSLTVLIAASAIQ 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 135 GL--SLSGVAAVGMT---YLSEEIHPSVVAFSMGLYISGnsiggMSGRLLTGVFTDFFGWRIALAVISGFALAAALMFWR 209
Cdd:PRK11652 107 GLgtGVGGVMARTLPrdlYEGTQLRHANSLLNMGILVSP-----LLAPLIGGLLTTLFGWRACYLFLLLLGAGVTFSMAR 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 210 ILPESrhfRPTSLRPKSLLINFRLHWRDRGlpllfLEGFLLM--GSF--VTLFNYIGYRLMLSPWSLSQAVVGLLSV--- 282
Cdd:PRK11652 182 WMPET---RPADARRTRVLASYRTLLSNRR-----FNCYLLMliGTLagIAVFEACSGVLMGAVLGLSSMTVSILFIlpi 253
|
....*...
gi 503995541 283 -AYLTGTW 289
Cdd:PRK11652 254 pAAFFGAW 261
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
36-208 |
1.29e-05 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 46.77 E-value: 1.29e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 36 RVTLALFSAGLATFALLYCVQPIL-PVLSSEFGVSPASSSISLSISTAMLAVGLLFTGPLSDAIGRKQVMVTALVLASCC 114
Cdd:cd17324 198 PRLRLAYLITFLLFGGFFALYTYLaPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAAL 277
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 115 SLLSTMMSSWHGILMMRALIGLSLSGVAAVGMTYLSEeIHPSVVAFSMGLYISGNSIGGMSGRLLTGVFTDFFGWRIALA 194
Cdd:cd17324 278 LLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLR-LAPEARGLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGW 356
|
170
....*....|....
gi 503995541 195 VISGFALAAALMFW 208
Cdd:cd17324 357 VGAALLLLALLLAL 370
|
|
| PRK15403 |
PRK15403 |
multidrug efflux MFS transporter MdtM; |
92-247 |
1.37e-05 |
|
multidrug efflux MFS transporter MdtM;
Pssm-ID: 237958 [Multi-domain] Cd Length: 413 Bit Score: 47.13 E-value: 1.37e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 92 GPLSDAIGRKQVMVT-ALV--LASCCSLLSTMMSSWhgiLMMRALIGLSLSGVAAVGMTYLSEEIHPSVVAFSMGLYISG 168
Cdd:PRK15403 72 GPLSDRIGRRPVLITgALIftLACAATLFTTSMTQF---LIARFIQGTSICFIATVGYVTVQEAFGQTKGIKLMAIITSI 148
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 503995541 169 NSIGGMSGRLLTGVFTDFFGWRIALAVISGFALAAALMFWRILPESRHFRPTSLRPKSLLINFRLHWRDRglplLFLEG 247
Cdd:PRK15403 149 VLVAPIIGPLSGAALMHFVHWKVLFAIIAVMGLIAFVGLLLAMPETVKRGAVPFSAKSVLRDFRNVFRNR----LFLTG 223
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
36-210 |
1.40e-05 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 46.79 E-value: 1.40e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 36 RVTLALFSAGLATFALLYCVQPILP-VLSSEFGVSPASSSISLSISTAMLAVGLLFTGPLSDA-IGRKQVMVTALVLasc 113
Cdd:cd17474 198 RGLLTFLVSAFLYFFLYFAFLTYLPfLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLKKrFGARRILVIGLLL--- 274
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 114 CSLLSTMMSSWHGILMMraLIGLSLSGVA-----AVGMTYLSEEIHPSVVAFSMGLYISGNSIGGMSGRLLTGVFTDFFG 188
Cdd:cd17474 275 YALSLLLLGFVPSLALL--LIAIVLFGLGlglnlPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFG 352
|
170 180
....*....|....*....|..
gi 503995541 189 WRIALAVISGFALAAALMFWRI 210
Cdd:cd17474 353 LSAPFLVGAAIALAAAVLLALL 374
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
19-208 |
1.43e-05 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 46.82 E-value: 1.43e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 19 IAPQPNQFIKRGTPQFIRVTLALFSAGLATFALLYC-VQPILPVLSSEFGVSPASSSISLSISTAMLAvgLLFTGPLSDA 97
Cdd:cd17489 176 VAAEEAEAGTRAFRRLVEKKVLPPALILFLASIAYGaISTFLPLYAAERGISNAGLFFTVYAIALLLS--RPFSGKLSDR 253
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 98 IGRKQVMVTALVLASCCSLLSTMMSSWHGILMMRALIGLSLSGVAAVGMTYLSEEIHPSVVAFSMGLYISGNSIGGMSGR 177
Cdd:cd17489 254 KGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGG 333
|
170 180 190
....*....|....*....|....*....|.
gi 503995541 178 LLTGVFTDFFGWRIALAVISGFALAAALMFW 208
Cdd:cd17489 334 LLLGLVAELFGYRAMFLLAAVVVLLALVLYI 364
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
86-384 |
1.58e-05 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 46.84 E-value: 1.58e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 86 VGLLFTGPLSDAIGRKQVMVTALVLASCCSLLSTMMSSWHGILMMRALIGLSLSGVAAVGMTYLSEEIHPSV--VAFSMg 163
Cdd:cd17329 50 VASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENrtRAFSL- 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 164 LYISGNsIGGMSGRLLTGVFTDFFGWRIALAVISGFALAAALMFWrILPESRHFRPTSlRPKSLLINFRLHWRDRGLPLL 243
Cdd:cd17329 129 LYWAIN-LGVAIGPLLGGLLLLYSFRLLFLAAAVLFLLAALVLLF-LLPETRPKRRAA-EKTEILRGYKIVLRDRAFLLF 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 244 FLEGFLLMGSFVTLFNYIGYRLMLSPWSLSQAVVGLLSVAYLTGTWSSPKAGAMTVRYGRGPVLLFSTAVM-LGGLLLTL 322
Cdd:cd17329 206 LLASFLISLIYFQLESTLPVYVVEILGLGESLLGLLLALNALLIVLLQFPVARLVERFRLRKILMIGILLFaIGFAVLAF 285
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 503995541 323 FSSLWLIFIGMLLFSAGFFAAHSVASSWIGPRA-RRARGQASSLYLFSYYLGSSMAGTLGGVF 384
Cdd:cd17329 286 ANTLAVLILAMIVLTLGEMLVFPAVQTLVAALApPDKRGSYMGFYALAWGLGRAIGPLVGGLL 348
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
56-396 |
2.17e-05 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 46.44 E-value: 2.17e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 56 QPILPVLSSEFGVSPASSSISLSISTAMLAVGLLFTGPLSDAIGRKqvmvTALVLA-SCCSLLSTMMSSWHGILMmrali 134
Cdd:cd17331 20 QPVLPYLTKKLGVDSVVFGYLQTTFSVLQLVGGPLFGRFGDLFGPR----AALVLSfLSSALSYLLLAFASSVPM----- 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 135 gLSLSGVAAVGM-------TYLSEEIHPSVVAFSMGLYISGNSIGGMSGRLLTGVFTDFFGWRIALAVISGFALAAALMF 207
Cdd:cd17331 91 -LFLSRLPSVFMhamqaaqMVVTDLTDPGERAAALGRLGLSYGIGMVVGSFLGGLLTKKFGEQAAALVAAVGSLLSIVLV 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 208 WRILPESRHFRPTSLRPKS-------LLINFRLHWRDRGLPllflegFLLMGSFVTLFNYIGYRLMLSPWS-----LSQA 275
Cdd:cd17331 170 ILLIPSNTKSKREKEAKESasppsvfNLKEILRLLRLPGVA------FLLLVKLLSGLPIGMFQSMFSLVAmdffgLTPE 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 276 VVG-LLSVAYLTGTWS-SPKAGAMTVRYGRGPVLLFSTAVM-LGGLLLTLFSSLWLIFIGMLLFSAGFFAAHSVASSWIG 352
Cdd:cd17331 244 ENGyLMSYAGVLGMVVqGLLVGPLTKRFGERSLLKLSVALLaIGYLLLAFVTTVWQLLVLLLPLVIGGSVLYTVITSLLT 323
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 503995541 353 PRARRA-RGQASSLYLFSYYLGSSMAGTLGGVFWHNYGWNGVGGF 396
Cdd:cd17331 324 KAVPPEdTGTALGLSHALFSLVRTVSPTIGGALLQAYGFPSFGLL 368
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
35-208 |
2.78e-05 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 46.00 E-value: 2.78e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 35 IRVTLALFSAGLATFALLycvqpILpvLSSEFGVSPASSSISLSISTAMLAVGLLFTGPLSDAIGRKQVMVTALVLASCC 114
Cdd:cd17370 205 YLLAVALFALGNFSFAFL-----IL--RAQELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALA 277
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 115 SLLSTMMSSWHGILMMRALIGLSLSGVAAVGMTYLSEEIHPSVVAFSMGLYISGNSIGGMSGRLLTGVFTDFFGWRIALA 194
Cdd:cd17370 278 YLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFL 357
|
170
....*....|....
gi 503995541 195 VISGFALAAALMFW 208
Cdd:cd17370 358 FSAVLALIALLLLL 371
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
89-208 |
4.40e-05 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 45.23 E-value: 4.40e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 89 LFTGPLSDAIGRKQVMVTALVLASCCSLLSTMMSSWHGILMMRALIGLSLSGVAAVGMTYLSEEIhPSVVAFSMGLYISG 168
Cdd:cd17471 253 LLAGLLAKRFGKRRLLLAGFLAGVLFYLGLALATSLWQLIALQLLNAIFIGITAGLGISYFQDLM-PGQPGLATTLYSNA 331
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 503995541 169 NSIGGMSGRLLTGVFTDFFGWRIALAVISGFALAAALMFW 208
Cdd:cd17471 332 SRIGSLLGGLLAGVIAQYFGYRAVFLVCAVLALLALVLLL 371
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
85-207 |
4.74e-05 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 45.25 E-value: 4.74e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 85 AVGLLFTGPLSDAIGRKQVMVTALVLASCCSLLSTMMSSWHGILMMRALIGLSLSGVAAVGMTYLSEEIHPSVVAFSMGL 164
Cdd:cd17502 44 TAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPRERGKYQGY 123
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 503995541 165 YISGNSIGGMSGRLLTGVFTDFFGWR-----------IALAVISGFALAAALMF 207
Cdd:cd17502 124 IGAVFGIASVAGPLIGGAFTDHLSWRwcfyinlpiggLALALLRTILLSSIFGF 177
|
|
| MFS_NIMT_CynX_like |
cd17339 |
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator ... |
55-381 |
5.65e-05 |
|
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli 2-nitroimidazole transporter (NIMT) and cyanate transport protein CynX, and similar proteins. NIMT, also called YeaN, confers resistance to 2-nitroimidazole, the antibacterial and antifungal antibiotic, by mediating the active efflux of this compound. CynX is part of an active transport system that transports exogenous cyanate into E. coli cells. The NIMT/CynX-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340897 [Multi-domain] Cd Length: 374 Bit Score: 44.87 E-value: 5.65e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 55 VQPILPVLSSEFGVSPASSSISLSISTAMLAVGLLFTGPLSDAIGRKQVMVTALVLASCCSLLSTMMSSWhGILMMRALI 134
Cdd:cd17339 18 VGPLLPEIRDDLGLSASQAGLLTTLPLLCFAVFSPLAPRLARRFGLERTLLLALLLLAAGILLRSLGGIA-LLFLGTALA 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 135 GLSLsGVAAVGMTYLSEEIHPSVVAFSMGLYISGNSIGGMSGRLLTGVFTD--FFGWRIALAVISGFALAAALMFW-RIL 211
Cdd:cd17339 97 GAGI-AVGNVLLPSLIKRDFPRRVGLMTGLYTTSMNLGAALASGLSVPLAQalGGGWRGALAIWALPALLALLIWLpQLR 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 212 PESRHFRPTSLRPKSLLINFRLHWrdrGLPLLF-LEGFL---LMGSFVTLFNYIGYR-----LMLSPWSLSQAVVGLLSV 282
Cdd:cd17339 176 RRKRAAAAAAPLTKISVWRSPLAW---QVTLFMgLQSLLfytLMAWLPTILIDAGLSaatagWLLSLFQLVGIPASLLVP 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 283 AYLTGTWSspkagamtvrygRGPVLLFSTAVMLGGLLLTLFSSLWLIFIGMLLFSAGFFAAHSVASSWIGPRARRARgQA 362
Cdd:cd17339 253 ILATRLKN------------QRPIVVLLAVLFIIGVLGLLFAPTALALLWAVLLGLGGGAAFSLALTLISLRSSDPA-EA 319
|
330
....*....|....*....
gi 503995541 363 SSLylfsyylgSSMAGTLG 381
Cdd:cd17339 320 AAL--------SGMAQSVG 330
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
236-393 |
7.33e-05 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 44.58 E-value: 7.33e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 236 RDRGLPLLFLEGFLLMGSFVTLFNYIGYRLMLSPWSLSQAVVGLLSVAY-LTGTWSSPKAGAMTVRYGRGPVLLFSTAVM 314
Cdd:COG2814 6 RRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYlLGAALGAPLAGRLADRFGRRRVLLLGLLLF 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 315 LGGLLLTLFS-SLWLIFIGMLLFSAGFFAAHSVASSWIGPRA-RRARGQASSLYLFSYYLGSSMAGTLGGVFWHNYGWNG 392
Cdd:COG2814 86 ALGSLLCALApSLWLLLAARFLQGLGAGALFPAALALIADLVpPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRW 165
|
.
gi 503995541 393 V 393
Cdd:COG2814 166 V 166
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
32-210 |
7.81e-05 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 44.48 E-value: 7.81e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 32 PQFIRVTLALFSAGLATFALLYCVQPILpvlSSEFGVSPASSSISLSISTAMLAVGLLFTGPLSD---AIGRKQVMVTAL 108
Cdd:cd17319 179 RQVWGLALGYFGINYALYGLLTWLPTYL---KQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDrllRGARRLVIIIGL 255
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 109 VLASCCSLLSTMMSSWHGILMMRALIGLSLSGVAAVGMTYLSEEIHPSVVAFSMGLYISGNSIGGMSGRLLTGVFTDFFG 188
Cdd:cd17319 256 LLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATG 335
|
170 180
....*....|....*....|...
gi 503995541 189 -WRIALAVISGFALAAALMFWRI 210
Cdd:cd17319 336 sYTAAFLFLAAVALLAALLVLLL 358
|
|
| MFS_3 |
pfam05977 |
Transmembrane secretion effector; This is a family of transport proteins. Members of this ... |
89-389 |
1.29e-04 |
|
Transmembrane secretion effector; This is a family of transport proteins. Members of this family include a protein responsible for the secretion of the ferric chelator, enterobactin, and a protein involved in antibiotic resistance.
Pssm-ID: 399164 [Multi-domain] Cd Length: 523 Bit Score: 43.97 E-value: 1.29e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 89 LFTGPLSDAIGRKQVMVTALVLASCCSLLsTMMSSWHGILMMRALIGLSLSG-----------VAAVGMTYLSEEIHPSV 157
Cdd:pfam05977 63 IPAGALADNFDRRKIMLAGQLLLALVSTL-LTLLAGLGLLSPWLLLGLTFLGgigtalmdpawQASVPELVPRRDLPAAV 141
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 158 VAFSMGLYISgNSIGGMSGrlltGVFTDFFG--WRIALAVISGFALAAALMFWRilpesRHFRPTSLRPKSLLINFRLHW 235
Cdd:pfam05977 142 ALNSVGYNIA-RSVGPALG----GVLLAAFGpaFTFALNALSYFAVIAALWRWK-----RAAPASPLPRERIFGAVRAGL 211
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 236 R----DRGLPLLFLEGFLLMGSFVTLF-------------NYIGYRLMLSPWSLSqAVVGLLSVAYLTGTWSSPKAgamt 298
Cdd:pfam05977 212 RftamSRELRSVLVRAFAFGLSASAVWallplvardlldgDAIFYGILLGAVGVG-AILGALSLPRLRERLGSDRL---- 286
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 299 vrygrgpVLLFSTAVMLGGLLLTLFSSLWLIFIGMLLFSAGFFAAHS---VASSWIGPRARRARgqASSLYLFSYYLGSS 375
Cdd:pfam05977 287 -------VLLASVVTALVLLSLALAPNLWLAIPVLLLGGAAWITALTtlnVAVQLSVPRWVRGR--ALAVYQTVFFGGMA 357
|
330
....*....|....
gi 503995541 376 MAGTLGGVFWHNYG 389
Cdd:pfam05977 358 AGSWLWGAVAEALS 371
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
40-208 |
1.31e-04 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 43.70 E-value: 1.31e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 40 ALFSAGLATFallycvqpiLPVLSSEFGVSPASSSISLSISTAMLAVGLLFTGPLSDAIGRKQVMVTALVLASCCSLLST 119
Cdd:cd17478 208 SWVLSSLTTF---------LPFYLVQRGYSLVFAGLLLSLFLFAGAIGTLIGGPLSDRFGRRRVIIASLLLAAPFLLLFL 278
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 120 MMSSWHGILMMrALIGLSLSGVAAVGMTYlSEEIHPSVVAFSMGLYIS-GNSIGGMsGRLLTGVFTDFFGWRIALAVISG 198
Cdd:cd17478 279 LTPGIWSYILL-VLAGFLLFASFPVTVVL-AQELLPGNVGLASGLMMGlSFGLGGI-GAPVLGALADAFGLESVLLILAL 355
|
170
....*....|
gi 503995541 199 FALAAALMFW 208
Cdd:cd17478 356 LPLLGALLAF 365
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
6-206 |
1.63e-04 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 43.37 E-value: 1.63e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 6 TVDTAPANDVSDIIAPQPNQFIKrgTPQFIRVTLALFsagLATFALLYCVQPILPVLSSEFGVSPASSSISLSISTAMLA 85
Cdd:cd17353 189 GVDPLANNAENSPRDYTPREMLR--TPTFWLLWLMFF---LNATAGLMLIGQAKPIGQEFAGLDAGIAALAVSILSIFNG 263
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 86 VGLLFTGPLSDAIGRKQVMVTALVLASCCSLLSTMMSSWHGILM-MRALIGLSLSGVAAVGMTYLSEEIHPSVVAFSMGL 164
Cdd:cd17353 264 GGRPFWGWLSDKIGRKNTLSIAFLIQGVAMFLLPFIGSVAVLFVlGVALIGFCYGGGFALFPALTADFFGTKNAGTNYGL 343
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 503995541 165 YISGNSIGGMSGRLLTGVFTDFFGWRIALAVISGFALAAALM 206
Cdd:cd17353 344 LYTAKGVGGLIGPIIAAYVLYTGGYNAAFIIAAALSLVALAL 385
|
|
| MFS_GLUT_Class1_2_like |
cd17357 |
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ... |
85-230 |
1.67e-04 |
|
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340915 [Multi-domain] Cd Length: 447 Bit Score: 43.79 E-value: 1.67e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 85 AVGLLFTGPLSDAIGRKQVMV---TALVLASCCSLLSTMMSSWHGILMMRALIGLSLS-GVAAVGMtYLSeEIHPSVVAF 160
Cdd:cd17357 63 AIGSFISAFLANRFGRKNGLLisnALLVVSSLLMFLSKSAKSPELLIFGRFLVGIACGlSTGFVPM-YLQ-EISPSELRG 140
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 503995541 161 SMGLYisgNSIGGMSGRLLTGVFT------DFFGWRIALAVISGFALaAALMFWRILPESrhfrptslrPKSLLIN 230
Cdd:cd17357 141 ALGSL---TQIGVTLGILLGQVFGlpsvlgTETLWPYLLFFPGIPAL-LQLAALPFFPES---------PKFLLIS 203
|
|
| PRK12307 |
PRK12307 |
MFS transporter; |
40-195 |
1.68e-04 |
|
MFS transporter;
Pssm-ID: 237051 [Multi-domain] Cd Length: 426 Bit Score: 43.76 E-value: 1.68e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 40 ALFSAGLA------TFALLYCvqpILPVLSSEFGVSPASSSISLSISTAMLAVGLLFTGPLSDAIGRKQVMVTALVLASC 113
Cdd:PRK12307 19 ALFSAWLGyvfdgfDFMLIFY---IMYLIKADLGLTDMEGAFLATAAFIGRPFGGALFGLLADKFGRKPLMMWSIVAYSV 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 114 CSLLSTMMSSWHGILMMRALIGLSLSGVAAVGMTYLSEEIHPSVVAFSMGLYISGNSIGGMSGRLLTGVFTDFFGWRIAL 193
Cdd:PRK12307 96 GTGLSGLASGVIMLTLSRFIVGMGMAGEYACASTYAVESWPKHLKSKASAFLVSGFGIGNIIAAYFMPSFAEAYGWRAAF 175
|
..
gi 503995541 194 AV 195
Cdd:PRK12307 176 FV 177
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
39-205 |
2.41e-04 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 42.93 E-value: 2.41e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 39 LALFSAGLATFALLycvqPILPVLSSEFGVSPASSSISLsisTAMLAVGLLFTGP---LSDAIGRKQVM-VTALVLASCC 114
Cdd:cd17477 195 LGAFVAGFLEGAFY----SLLPLYGLRLGLSVAQAALLL---AAFVLGGLLLQWPlgwLADRFDRRRVLlGCALLGALAA 267
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 115 SLLSTMMSSWHGILMMRALIGLSLSGVAAVGMTYLSEEIHPSVVAFSMGLYISGNSIGGMSGRLLTGVFTDFFGWRIALA 194
Cdd:cd17477 268 LLLPLVPGLPLALLVLLFLWGGAAGPLYTLALALAGDRLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFGPHGLFL 347
|
170
....*....|.
gi 503995541 195 VISGFALAAAL 205
Cdd:cd17477 348 FLAAVALLFLL 358
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
36-210 |
3.29e-04 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 42.60 E-value: 3.29e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 36 RVTLALFSAGLATFALLYCVQPILPVLSSEFGVSPASSSISLSISTAMLAVGLLFTGPLSDAIGRKQVMVTALVLASCCS 115
Cdd:cd06173 209 LLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLAL 288
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 116 LLSTMMSSWHGILMMRALIGLSLSGVAAVGMTYLSEEIHPSVVAFSMGLYISGNSIGGMSGRLLTGVFTDFFGWRIALAV 195
Cdd:cd06173 289 LVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLL 368
|
170
....*....|....*
gi 503995541 196 ISGFALAAALMFWRI 210
Cdd:cd06173 369 AGALLLLAALLLLLL 383
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
85-210 |
4.48e-04 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 42.06 E-value: 4.48e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 85 AVGLLFTGPLSDAIGRKQVMVTALVLASCCSLLSTMMSSWHGILMMRALIGLSLSGVAAVGMTYLSEEIHPSVVAFSMGL 164
Cdd:COG2270 288 ALGALLFGRLDDRIGPKRVILVSLVIWIVVCLAAYFLTTALAFWILGLLIGLVMGGIQALSRSLLARLIPPGREAEFFGL 367
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 503995541 165 YisgnsigGMSGR-------LLTGVFTDFFG-WRIALAVISGFALAAALMFWRI 210
Cdd:COG2270 368 Y-------ALSGKaasflgpLLFGLVTQLTGsQRLGILSLIVFFVIGLVLLLRV 414
|
|
| synapt_SV2 |
TIGR01299 |
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ... |
34-211 |
4.71e-04 |
|
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.
Pssm-ID: 130366 [Multi-domain] Cd Length: 742 Bit Score: 42.66 E-value: 4.71e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 34 FIRVTLALFSAGLATFALLYcvqpILPVLSSEFGVSPASSSISLSISTAMLAVGLLFTGPLSDAIGRKQVMVTALVLASC 113
Cdd:TIGR01299 169 FFVLGLALMADGVEVFVVGF----VLPSAEKDLCIPDSGKGMLGLIVYLGMMVGAFFWGGLADKLGRKQCLLICLSVNGF 244
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 114 CSLLSTMMSSWHGILMMRALIGLSLSGVAAVGMTYLSEEIHPSvvafSMGLYISGNSIGGMSGrlltGVFTDFFGWRIAL 193
Cdd:TIGR01299 245 FAFFSSFVQGYGFFLFCRLLSGFGIGGAIPIVFSYFAEFLAQE----KRGEHLSWLCMFWMIG----GIYAAAMAWAIIP 316
|
170 180
....*....|....*....|
gi 503995541 194 AVISGFALAAALMF--WRIL 211
Cdd:TIGR01299 317 HYGWSFQMGSAYQFhsWRVF 336
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
31-213 |
4.82e-04 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 41.90 E-value: 4.82e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 31 TPQFIRVTLalFSAGLATFALL--YCVQPILPV-LSSEFGVSPASSSISLSISTAMLAVGLLFTGPLSDAIGRKqVMVTA 107
Cdd:cd17371 204 SPPLLRTTL--LASLLATGALGgyYGITTWLPSyLTGERGLSFEGSAGYLVVTILGGFLGYLAGGFLADRIGRR-NNFAL 280
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 108 LVLASCCSLLSTMM--SSWHGILMMRALIGLSLSGVAAVGMTYLSEEIHPSVVAFSMGLYISGNSIGGMSGRLLTGVFTD 185
Cdd:cd17371 281 FALGSAISILLYFFlpLSPTLILILGFPLGFFASGPFSGMGAYLTELFPTAVRATAQGFCYNVGRIIGALFPFLVGFLAT 360
|
170 180
....*....|....*....|....*...
gi 503995541 186 FFGWRIALAVISGFALAAALMFWRILPE 213
Cdd:cd17371 361 SGSLGTAIAVFAAVYYIAGLVLALLLPE 388
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
33-208 |
5.50e-04 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 42.03 E-value: 5.50e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 33 QFIRVTLALFSAGLATFALLYCVQPILPVLSSEFGVSPASSSISLSISTAMLAVGLLFTGPLSD-AIGRKQVMVTALVLA 111
Cdd:cd06174 201 KNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDrLIGRKPLLLIGLLLM 280
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 112 SCCSLLSTMMSSWHGILMMRALIGLSLSGVAAVGMTYLSEEIHPSVVAFSMGLYISGNSIGGMSGRLLTGVFTD-FFGWR 190
Cdd:cd06174 281 ALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAaTFGLT 360
|
170
....*....|....*...
gi 503995541 191 IALAVISGFALAAALMFW 208
Cdd:cd06174 361 GAFLVLAVLLLLAAILLL 378
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
34-176 |
5.97e-04 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 41.63 E-value: 5.97e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 34 FIRVTLALFSAGLATFALLYCVQPILPVLSSEFGVSPASSSISLSISTAMLAVGLLFTGPLSDAIGRKQVMVTALVLASC 113
Cdd:pfam07690 198 LRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLIL 277
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 503995541 114 CSL---LSTMMSSWHGILMMRALIGLSLSGVAAVGMTYLSEEIHPSVVAFSMGLYISGNSIGGMSG 176
Cdd:pfam07690 278 AALgllLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALG 343
|
|
| PRK10091 |
PRK10091 |
MFS transport protein AraJ; Provisional |
41-342 |
6.61e-04 |
|
MFS transport protein AraJ; Provisional
Pssm-ID: 182234 [Multi-domain] Cd Length: 382 Bit Score: 41.62 E-value: 6.61e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 41 LFSAGLATFAL---LYCVQPILPVLSSEFGVSPASSSISLSISTAMLAVGLLFTGPLSDAIGRKQVMVTALVLASCCSLL 117
Cdd:PRK10091 5 ILSLALGTFGLgmaEFGIMGVLTELAHDVGISIPAAGHMISYYALGVVVGAPIIALFSSRYSLKHILLFLVALCVIGNAM 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 118 STMMSSWHGILMMRALIGLSLSGVAAVGMTYLSEEIHPSVVAFSMGLYISGNSIGGMSGRLLTGVFTDFFGWRIALAVIS 197
Cdd:PRK10091 85 FTLSSSYLMLAIGRLVSGFPHGAFFGVGAIVLSKIIKPGKVTAAVAGMVSGMTVANLLGIPLGTYLSQEFSWRYTFLLIA 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 198 GFALAAALMFWRILPESRHFRPTSLRPKSLLINFRLHWrdrglpLLFLEGFLLMGSFVTLFNYIGyRLMLSPWSLSQAVV 277
Cdd:PRK10091 165 VFNIAVLASIYFWVPDIRDEAKGGLREQFHFLRSPAPW------LIFAATMFGNAGVFAWFSYIK-PYMMFISGFSETSM 237
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 503995541 278 GLLSV-AYLTGTWSSPKAGAMTVRYGRGPVLLFSTAVMLGGLLLTLFSS--LWLIFIGMLLFSAGFFA 342
Cdd:PRK10091 238 TFIMMlVGLGMVLGNLLSGRLSGRYSPLRIAAVTDFIIVLALLMLFFFGgmKTASLIFAFICCAGLFA 305
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
84-208 |
1.08e-03 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 40.64 E-value: 1.08e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 84 LAVGLLFTGPLSDAIGRKQVMVTALVLASCCSLLSTMMSSWHGILMMRALIGLSLSGVAAVGMTYLSEEIHPSVVAFSMG 163
Cdd:cd17317 38 VLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVGFVLGMEIVGPKYRSFVGI 117
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 503995541 164 LYISGNSIGGMSGRLLTGVFTDffgWRIALAVISGFALAAALMFW 208
Cdd:cd17317 118 LFGLFWALGYMLLALLAYLIRD---WRWLQLAISLPGLLFLLLLW 159
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
156-340 |
1.84e-03 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 40.28 E-value: 1.84e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 156 SVVAFSMGLYISGNSIGGMSGRLLTGVFTD---FFGWRIALAVISGFALAAALMFWRILPESRHFRPTSLRPKSLLINFR 232
Cdd:cd17332 136 SLTSWRMFFATIGGLLVTVLPPPLVAYFGGgnaSRGYFLTALIIGIIGIILLLICFFGTRERVVPPEEEKSKLPLLKSLK 215
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 233 LHWRDRGLPLLFLEGFLLMGSFVT----LFNYIGYRLMLSPWSLSqAVVGLLSVAYLTGTWSSPKagamTVRYGRGPVLL 308
Cdd:cd17332 216 ALLKNRPFLILLLAYLLYFLAFNIvntvLVYYFKYVLGGRAELVL-LLLLILSGALLALLPWPPL----KKRFGKKKAFF 290
|
170 180 190
....*....|....*....|....*....|....*
gi 503995541 309 FSTAVMLGGLLLTLF---SSLWLIFIGMLLFSAGF 340
Cdd:cd17332 291 IGLLLAILGLLLLFFlppGNLVLILVLAVLAGIGY 325
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
84-206 |
1.89e-03 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 40.00 E-value: 1.89e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 84 LAVGLLFTGPLSDAIGRKQVMVTALVLASCCSLLSTMMSSWHGILMMRALIGLSLSGVAAVGMTYLSEEI-HPSVVAfsM 162
Cdd:cd17333 248 ITIGRLLGGPISRRIKPHTLLVLSGSGALLGLLILLLAPTLVVGLVATALLGLFMAALFPTILSLGISNLpYAKGKG--T 325
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 503995541 163 GLYISGNSIGGMSGRLLTGVFTDFFGWRIALAVISGFALAAALM 206
Cdd:cd17333 326 SVLLAAGSIGGAIIPFIMGFIAEAVGIQTAMLLITILYAIIFVL 369
|
|
| MFS_TetA |
cd17388 |
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ... |
291-383 |
1.94e-03 |
|
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 40.31 E-value: 1.94e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 291 SPKAGAMTVRYGRGPVLLFSTAVM-LGGLLLTLFSSLWLIFIGMLLfsAGFFAAH-SVASSWI---GPRARRAR--GQAS 363
Cdd:cd17388 55 APILGALSDRFGRRPVLLLSLAGAaLDYLLMAFAPTLWWLYLGRII--AGITGATgAVAAAYIadvTPPEQRARnfGLLG 132
|
90 100
....*....|....*....|
gi 503995541 364 SLYLFSYYLGSSMAGTLGGV 383
Cdd:cd17388 133 AAFGLGFIAGPALGGLLGEI 152
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
247-393 |
2.04e-03 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 40.09 E-value: 2.04e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 247 GFLLMGSFVTLFNYIGYRLMLSPWSLSQAVVGLLSVAY-LTGTWSSPKAGAMTVRYGRGPVLLFSTAVM-LGGLLLTLFS 324
Cdd:pfam07690 4 AAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFsLGYALAQPLAGRLSDRFGRRRVLLIGLLLFaLGLLLLLFAS 83
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 325 SLWLIFIGMLLFSAGFFAAHSVASSWIGPRA-RRARGQASSLYLFSYYLGSSMAGTLGGVFWHNYGWNGV 393
Cdd:pfam07690 84 SLWLLLVLRVLQGLGAGALFPAALALIADWFpPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAA 153
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
39-389 |
2.74e-03 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 39.45 E-value: 2.74e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 39 LALFSAGLATFALLycvqPILPV-LSSEFGVSPASSSISLSIsTAMLAVGL-LFTGPLSDAIG-RKQVMVTALVLASC-C 114
Cdd:cd17471 3 LATLLTGLAGAFVL----PYLSLfLTEELGASPLQIGIFMTL-SALSGIVVsQWLGRLSDRGGdRKPLILLALLAGALgY 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 115 SLLSTMMSSWhgilmMRALIGLSLSGVAAVGMTYL-------SEEIHPSVVAFSMGLYISGNSIGGMSGRLLTGVFTDFF 187
Cdd:cd17471 78 LLFAFLRNYW-----VLLLVGVVLLSLGAAAFPQLfalareyADRSSGRDATLFNSVLRAAFSLAWVIGPPLAFLLLDVL 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 188 GWRIALAVISGFALAAALMFWRILPESRHFRPTSLRPKSllinfRLHWRDRGLPLLFLEGFLLMgsFVTLFNYIGYR--L 265
Cdd:cd17471 153 GFTGLFLLAALLYLVVALLVLFLLPSVKPPAQKATPASS-----LVKAPVNRRLLLLFAAFTLL--FAANSMYIIAMplY 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 266 MLSPWSLSQAVVGLL-SVAYLTGTWSSPKAGAMTVRYGRGPVLLFSTAVMLGGLLLTLFSSLWLIFIGMLLFSAGFFAAH 344
Cdd:cd17471 226 VTNELGGSESWVGLLfGLAAALEIPIMLLAGLLAKRFGKRRLLLAGFLAGVLFYLGLALATSLWQLIALQLLNAIFIGIT 305
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 503995541 345 S-VASSWIGPRARRARGQASSLYLFSYYLGSSMAGTLGGVFWHNYG 389
Cdd:cd17471 306 AgLGISYFQDLMPGQPGLATTLYSNASRIGSLLGGLLAGVIAQYFG 351
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
92-212 |
2.88e-03 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 39.46 E-value: 2.88e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 92 GPLSDAIGRKQVMVTALVLASCCSLLSTMMSSWH--GILMMRALIGLsLSGVAAVGMTYL-SEEIHPSVVAFSMGLYISG 168
Cdd:cd17380 55 GYLADRFGGKKVLLLAVALWSLATLLTPLLAYSSlpLLILSRILLGL-GEGVHFPSMTSLfSRWVPVSERSRAVSIVTAG 133
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 503995541 169 NSIGGMSGRLLTGVFTDFFGWRIALAVISGFALAAALMFWRILP 212
Cdd:cd17380 134 SYLGTLLGGLIGPLLLEYYGWPSVFYFFGLLGLLWALVWLIYLP 177
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
31-182 |
2.89e-03 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 39.65 E-value: 2.89e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 31 TPQFIRVTLALFSAGLATFALLYCVQPILPVLSSEFGVSPASSSISLSISTAMLAVGLLFTGPLSDAIGRKQVMVTALVL 110
Cdd:TIGR00895 245 QGKTARITVLLWLLYFMLLVGVYFLTNWLPKLMVELGFSLSLAATGGALFNFGGVIGSIIFGWLADRLGPRVTALLLLLG 324
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 503995541 111 ASCCSLLSTMMSSWHGILMMRALIGLSLSGVAAVGMTYLSEEIHPSVVAFSMGLYISGNSIGGMSGRLLTGV 182
Cdd:TIGR00895 325 AVFAVLVGSTLFSPTLLLLLGAIAGFFVNGGQSGLYALMALFYPTAIRATGVGWAIGIGRLGAIIGPILAGY 396
|
|
| PRK08633 |
PRK08633 |
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated |
191-341 |
3.20e-03 |
|
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
Pssm-ID: 236315 [Multi-domain] Cd Length: 1146 Bit Score: 39.91 E-value: 3.20e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 191 IALAVISGFALAAALMFWRI--LPES---RHFRPTSLRPKSLLINFRLHWRDRGLPL--LFLEGFLLMGSFVTLfNYIGY 263
Cdd:PRK08633 180 PAGLVLLAVAVLGLIFAYRLpkVPAAapeVFDKKKYLFPKLLWRNLKLLRSDRVLWLaiIGLSYFWFISQLAQA-NFPAY 258
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 264 ---RLMLSPWSLSQAVVGLLSV-----AYLTGTWSSPKagamtVRYGRGPVLLFSTAVMLggLLLTLFSSLWLIFIGMLL 335
Cdd:PRK08633 259 akeVLGLDNTFQVQYLLAASAIgigigSLLAGRLSGRH-----IELGLVPLGALGLALSL--FLLPTAPSLASVLVLFFL 331
|
....*...
gi 503995541 336 F--SAGFF 341
Cdd:PRK08633 332 FgfSAGLF 339
|
|
| MFS_OAT |
cd17374 |
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ... |
82-208 |
4.25e-03 |
|
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340932 [Multi-domain] Cd Length: 341 Bit Score: 38.81 E-value: 4.25e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 82 AMLAVGLLFTGPLSDAIGRKQVMVTALVLASCCSLLSTMMSSWHGILMMRALIGLSLSGVAAVGMTYLSEEIHPSVVAFS 161
Cdd:cd17374 46 AGLLVGALIFGHLSDRFGRKFILLLSLLQLAIFGTCAAFAPTFPVYCVLRFLAGFAVSGISINTLILGTEWTTPRHRALA 125
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 503995541 162 MGLYISGNSIGGMsgrLLTGVFTDFFGWRIALAVISGFALAAALMFW 208
Cdd:cd17374 126 ITLTSCFFSIGQM---LLAGLAYAIRDWRLLQLVVSVPFFLFFLYSW 169
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
86-346 |
4.31e-03 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 39.05 E-value: 4.31e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 86 VGLLFTGPLSDAIGRKQVMVTALVLASCCSLLSTMMSSWHGI--------LMMRALIGLSLSGVAAVGMTYLSEEIHPSv 157
Cdd:cd17369 59 LGGVVFGHFGDRIGRKKTLVLTLLLMGIATFLIGLLPTYAQIgilapillVLLRLLQGLALGGEWGGAVLMAVEHAPPK- 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 158 vafSMGLYISGNSIGGMSGRLL-TGVF--------TDFF---GWRIALaVISGFALAAALMFWRILPESRHFRPT----S 221
Cdd:cd17369 138 ---RRGFYGSFPQLGAPVGLLLaTGVFlllsallsDEAFlswGWRIPF-LLSAVLVAVGLYIRLRLEETPVFRRAkeagQ 213
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503995541 222 LRPKSLLINFRLHWRDrglpllFLEGFLLMGSFVTLFnYIGYRLMLS----PWSLSQAVV-GLLSVAYLTGTWSSPKAGA 296
Cdd:cd17369 214 VVRAPLVEVLRRHWRA------LLLAIGLRLAENVLF-YLFTTFALSyatqTLGVDRSTVlLAVLIASVVAAITIPLFGW 286
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 503995541 297 MTVRYGRGPVLLFsTAVMLGGLLLTLFSSL-----WLIFIGMLLfsaGFFAAHSV 346
Cdd:cd17369 287 LSDRVGRRPVYLA-GALLAALFAFPFFWLLdtgstWLIVLAAVV---VLGVLHGM 337
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
85-151 |
7.29e-03 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 38.32 E-value: 7.29e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 503995541 85 AVGLLFTGPLSDAIGRKQVMVTALVLASCCSLLSTMMSSWHGILMMRALIGLSLSGVAAVGMTYLSE 151
Cdd:cd17359 50 AIGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFTIFIIARIIGGLAVGGASALVPMYIAE 116
|
|
| |
