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Conserved domains on  [gi|504065570|ref|WP_014299564|]
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MULTISPECIES: thioredoxin family protein [Bacteroidales]

Protein Classification

thioredoxin family protein( domain architecture ID 10590097)

thioredoxin family protein may function as a thiol disulfide reductase that catalyzes the reduction of protein disulfide bonds using an active site dithiol, present in a CXXC motif

CATH:  3.40.30.10
EC:  1.8.-.-
Gene Ontology:  GO:0015036
PubMed:  11441809|12074972|9099998|10049365|15558583|30367780
SCOP:  4000237

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Thioredoxin_3 pfam13192
Thioredoxin domain;
6-69 8.90e-17

Thioredoxin domain;


:

Pssm-ID: 433026 [Multi-domain]  Cd Length: 71  Bit Score: 67.24  E-value: 8.90e-17
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 504065570   6 LGTGCAGCKALHATVEQVVKELALEAVITKEEDLMKIMEYNVMTLPALVVDGKVVAKGKLSAKE 69
Cdd:pfam13192  1 LGPGCPKCPQLEKAVKEAAAELGIDAEVEKVTDFPEIAKYGVMSTPALVINGKVVSSGKVPSEE 64
 
Name Accession Description Interval E-value
Thioredoxin_3 pfam13192
Thioredoxin domain;
6-69 8.90e-17

Thioredoxin domain;


Pssm-ID: 433026 [Multi-domain]  Cd Length: 71  Bit Score: 67.24  E-value: 8.90e-17
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 504065570   6 LGTGCAGCKALHATVEQVVKELALEAVITKEEDLMKIMEYNVMTLPALVVDGKVVAKGKLSAKE 69
Cdd:pfam13192  1 LGPGCPKCPQLEKAVKEAAAELGIDAEVEKVTDFPEIAKYGVMSTPALVINGKVVSSGKVPSEE 64
redox_disulf_2 TIGR00412
small redox-active disulfide protein 2; This small protein is found in three archaeal species ...
 1-69 1.42e-11

small redox-active disulfide protein 2; This small protein is found in three archaeal species so far (Methanococcus jannaschii, Archeoglobus fulgidus, and Methanobacterium thermoautotrophicum) as well as in Anabaena PCC7120. It is homologous to thioredoxins, glutaredoxins, and protein disulfide isomerases, and shares with them a redox-active disulfide. The redox active disulfide region CXXC motif resembles neither thioredoxin nor glutaredoxin. A closely related protein found in the same three Archaea, described by redox_disulf_1, has a glutaredoxin-like CP[YH]C sequence; it has been characterized in functional assays as redox-active but unlikely to be a thioredoxin or glutaredoxin. [Unknown function, General]


Pssm-ID: 129506  Cd Length: 76  Bit Score: 54.14  E-value: 1.42e-11
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 504065570   1 MEIKVLGTGCAGCKALHATVEQVVKELALEAVITKEEDLMKIMEYNVMTLPALVVDGKVVAKGKLSAKE 69
Cdd:TIGR00412  1 MKIQIYGTGCANCQMTEKNVKKAVEELGIDAEFEKVTDMNEILEAGVTATPGVAVDGELVIMGKIPSKE 69
CnoX COG3118
Chaperedoxin CnoX, contains thioredoxin-like and TPR-like domains, YbbN/TrxSC family ...
 8-76 2.23e-06

Chaperedoxin CnoX, contains thioredoxin-like and TPR-like domains, YbbN/TrxSC family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 442352 [Multi-domain]  Cd Length: 105  Bit Score: 41.34  E-value: 2.23e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 504065570   8 TGCAGCKALHATVEQVVKELALEAVITK---EEDLMKIMEYNVMTLPALVV--DGKVVAK--GKLSAKEVKDVLTK 76
Cdd:COG3118   28 PWCGPCKMLAPVLEELAAEYGGKVKFVKvdvDENPELAAQFGVRSIPTLLLfkDGQPVDRfvGALPKEQLREFLDK 103
 
Name Accession Description Interval E-value
Thioredoxin_3 pfam13192
Thioredoxin domain;
6-69 8.90e-17

Thioredoxin domain;


Pssm-ID: 433026 [Multi-domain]  Cd Length: 71  Bit Score: 67.24  E-value: 8.90e-17
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 504065570   6 LGTGCAGCKALHATVEQVVKELALEAVITKEEDLMKIMEYNVMTLPALVVDGKVVAKGKLSAKE 69
Cdd:pfam13192  1 LGPGCPKCPQLEKAVKEAAAELGIDAEVEKVTDFPEIAKYGVMSTPALVINGKVVSSGKVPSEE 64
redox_disulf_2 TIGR00412
small redox-active disulfide protein 2; This small protein is found in three archaeal species ...
 1-69 1.42e-11

small redox-active disulfide protein 2; This small protein is found in three archaeal species so far (Methanococcus jannaschii, Archeoglobus fulgidus, and Methanobacterium thermoautotrophicum) as well as in Anabaena PCC7120. It is homologous to thioredoxins, glutaredoxins, and protein disulfide isomerases, and shares with them a redox-active disulfide. The redox active disulfide region CXXC motif resembles neither thioredoxin nor glutaredoxin. A closely related protein found in the same three Archaea, described by redox_disulf_1, has a glutaredoxin-like CP[YH]C sequence; it has been characterized in functional assays as redox-active but unlikely to be a thioredoxin or glutaredoxin. [Unknown function, General]


Pssm-ID: 129506  Cd Length: 76  Bit Score: 54.14  E-value: 1.42e-11
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 504065570   1 MEIKVLGTGCAGCKALHATVEQVVKELALEAVITKEEDLMKIMEYNVMTLPALVVDGKVVAKGKLSAKE 69
Cdd:TIGR00412  1 MKIQIYGTGCANCQMTEKNVKKAVEELGIDAEFEKVTDMNEILEAGVTATPGVAVDGELVIMGKIPSKE 69
CnoX COG3118
Chaperedoxin CnoX, contains thioredoxin-like and TPR-like domains, YbbN/TrxSC family ...
 8-76 2.23e-06

Chaperedoxin CnoX, contains thioredoxin-like and TPR-like domains, YbbN/TrxSC family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 442352 [Multi-domain]  Cd Length: 105  Bit Score: 41.34  E-value: 2.23e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 504065570   8 TGCAGCKALHATVEQVVKELALEAVITK---EEDLMKIMEYNVMTLPALVV--DGKVVAK--GKLSAKEVKDVLTK 76
Cdd:COG3118   28 PWCGPCKMLAPVLEELAAEYGGKVKFVKvdvDENPELAAQFGVRSIPTLLLfkDGQPVDRfvGALPKEQLREFLDK 103
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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