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Conserved domains on  [gi|504122490|ref|WP_014356476|]
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glycoside hydrolase family 99-like domain-containing protein [Acetobacterium woodii]

Protein Classification

glycoside hydrolase family 99-like domain-containing protein( domain architecture ID 10184107)

glycoside hydrolase family 99-like domain-containing protein is typically found within O-antigen biosynthesis clusters and bears resemblance to the GH71/GH99 family of alpha-1,2-mannosidases

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Glyco_tran_WbsX cd11579
Glycosyl hydrolase family 99-like domain of WbsX-like glycosyltransferases; Members of this ...
3-357 0e+00

Glycosyl hydrolase family 99-like domain of WbsX-like glycosyltransferases; Members of this domain family are found in proteins within O-antigen biosynthesis clusters in Gram negative bacteria, where they may function as glycosyl hydrolases and typically co-occur with glycosyltransferase domains. They bear resemblance to GH71 and the GH99 family of alpha-1,2-mannosidases and may share a similar cataltyic site and mechanism. The O-antigens are essential lipopolysaccharides in gram-negative bacteria's outer membrane and have been linked to pathogenicity.


:

Pssm-ID: 211420 [Multi-domain]  Cd Length: 347  Bit Score: 509.39  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504122490   3 KIIAFYLPQFHSIPENDEWWGKGFTEWTNTKKAMPLYKNHYQPKLPYGNNYYNLLNKETRLWQAKLAMEHGVYGFCYYHY 82
Cdd:cd11579    2 KVIAFYLPQFHPIPENDEWWGKGFTEWTNVKKAKPLFEGHYQPRVPLDLGYYDLRDPEVREKQAELAKEYGIDGFCYYHY 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504122490  83 WFNGKMLLNKPLEEVLKLNEPELPFCMCWANEPWTRTWDGGENEILMPQYYGNRDDWQKHFEYLLPFFKDSRYITVDEMP 162
Cdd:cd11579   82 WFGGKRLLEKPLEELLLSGEPDFPFCLCWANENWTRRWDGRDKEELLEQQYYGEEDWKEHFRYLLPYFKDPRYIKIDGKP 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504122490 163 LFLIYKTSLIENCDEMIKYWNELGVKNGLKGIYVAEELTGFQLKPCCKETRAVVEFEPTYTIRENADIFSRLILKIKyll 242
Cdd:cd11579  162 VFLIYRPELIPDPKETLELWRELAREAGLPGLYLVAVASFGIEDPRDLGFDAAVEFPPHYVVASELSKSRKLLKLKK--- 238
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504122490 243 rkkivsGKLIRFYDYDYIWNKIIKRKRKviDKKVFLGAFIDWDNSARKKYEAIIFKGASPQKFEKYIKKQL--MVAKELN 320
Cdd:cd11579  239 ------GFGGNVYDYDDLVKYILNRPDP--DYPYYPGVFPGWDNTPRRGKRGTIFVNSTPELFKKWLRKAIerAKARPED 310
                        330       340       350
                 ....*....|....*....|....*....|....*..
gi 504122490 321 SEFVFLNAWNEWAEGTYLEPDQKYGYAYLEAIKEAQN 357
Cdd:cd11579  311 ERLVFINAWNEWAEGAYLEPDLKYGYGYLEALKEALE 347
 
Name Accession Description Interval E-value
Glyco_tran_WbsX cd11579
Glycosyl hydrolase family 99-like domain of WbsX-like glycosyltransferases; Members of this ...
3-357 0e+00

Glycosyl hydrolase family 99-like domain of WbsX-like glycosyltransferases; Members of this domain family are found in proteins within O-antigen biosynthesis clusters in Gram negative bacteria, where they may function as glycosyl hydrolases and typically co-occur with glycosyltransferase domains. They bear resemblance to GH71 and the GH99 family of alpha-1,2-mannosidases and may share a similar cataltyic site and mechanism. The O-antigens are essential lipopolysaccharides in gram-negative bacteria's outer membrane and have been linked to pathogenicity.


Pssm-ID: 211420 [Multi-domain]  Cd Length: 347  Bit Score: 509.39  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504122490   3 KIIAFYLPQFHSIPENDEWWGKGFTEWTNTKKAMPLYKNHYQPKLPYGNNYYNLLNKETRLWQAKLAMEHGVYGFCYYHY 82
Cdd:cd11579    2 KVIAFYLPQFHPIPENDEWWGKGFTEWTNVKKAKPLFEGHYQPRVPLDLGYYDLRDPEVREKQAELAKEYGIDGFCYYHY 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504122490  83 WFNGKMLLNKPLEEVLKLNEPELPFCMCWANEPWTRTWDGGENEILMPQYYGNRDDWQKHFEYLLPFFKDSRYITVDEMP 162
Cdd:cd11579   82 WFGGKRLLEKPLEELLLSGEPDFPFCLCWANENWTRRWDGRDKEELLEQQYYGEEDWKEHFRYLLPYFKDPRYIKIDGKP 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504122490 163 LFLIYKTSLIENCDEMIKYWNELGVKNGLKGIYVAEELTGFQLKPCCKETRAVVEFEPTYTIRENADIFSRLILKIKyll 242
Cdd:cd11579  162 VFLIYRPELIPDPKETLELWRELAREAGLPGLYLVAVASFGIEDPRDLGFDAAVEFPPHYVVASELSKSRKLLKLKK--- 238
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504122490 243 rkkivsGKLIRFYDYDYIWNKIIKRKRKviDKKVFLGAFIDWDNSARKKYEAIIFKGASPQKFEKYIKKQL--MVAKELN 320
Cdd:cd11579  239 ------GFGGNVYDYDDLVKYILNRPDP--DYPYYPGVFPGWDNTPRRGKRGTIFVNSTPELFKKWLRKAIerAKARPED 310
                        330       340       350
                 ....*....|....*....|....*....|....*..
gi 504122490 321 SEFVFLNAWNEWAEGTYLEPDQKYGYAYLEAIKEAQN 357
Cdd:cd11579  311 ERLVFINAWNEWAEGAYLEPDLKYGYGYLEALKEALE 347
Glyco_tran_WbsX pfam14307
Glycosyltransferase WbsX; Members of this family are found in within O-antigen biosynthesis ...
4-352 3.94e-180

Glycosyltransferase WbsX; Members of this family are found in within O-antigen biosynthesis clusters in Gram negative bacteria, where they are predicted to function as glycosyltransferases.


Pssm-ID: 464132 [Multi-domain]  Cd Length: 311  Bit Score: 501.26  E-value: 3.94e-180
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504122490    4 IIAFYLPQFHSIPENDEWWGKGFTEWTNTKKAMPLYKNHYQPKLPYGNNYYNLLNKETRLWQAKLAMEHGVYGFCYYHYW 83
Cdd:pfam14307   1 VIAFYLPQFHPIPENDEWWGKGFTEWTNVKKAKPLFKGHYQPRLPADLGYYDLRLPEVRRAQAELAKEYGIYGFCYYHYW 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504122490   84 FNGKMLLNKPLEEVLKLNEPELPFCMCWANEPWTRTWDGGENEILMPQYYGnRDDWQKHFEYLLPFFKDSRYITVDEMPL 163
Cdd:pfam14307  81 FGGKRLLEKPLEELLESKEPDFPFCLCWANESWTRRWDGSDKEILIEQDYG-EEDDKAHFDYLLPYFKDPRYIKVDGKPL 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504122490  164 FLIYKTSLIENCDEMIKYWNELGVKNGLKGIYVAEELTGFQLKPCCKETRAVVEFeptytirenadifsrlilkikyllr 243
Cdd:pfam14307 160 FLIYRPDLIPDPKETIERWRELAKENGLGGIYLVGVQSFGDEDPRDLGFDAAVEF------------------------- 214
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504122490  244 kkivsgklirfyDYDYIWNKIIKRKRKviDKKVFLGAFIDWDNSARKKYEAIIFKGASPQKFEKYIKKQLMVAKELNSE- 322
Cdd:pfam14307 215 ------------DYDKLVRRILNRPPP--KYKLFPGVFPGWDNTPRRGKRGTIFHGATPEKFEKWLEKAVERAKQKPDEe 280
                         330       340       350
                  ....*....|....*....|....*....|.
gi 504122490  323 -FVFLNAWNEWAEGTYLEPDQKYGYAYLEAI 352
Cdd:pfam14307 281 rIVFINAWNEWAEGAYLEPDLKFGYAYLEAI 311
RgpF COG3754
Lipopolysaccharide biosynthesis protein [Cell wall/membrane/envelope biogenesis];
3-107 2.08e-14

Lipopolysaccharide biosynthesis protein [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442968 [Multi-domain]  Cd Length: 152  Bit Score: 69.70  E-value: 2.08e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504122490   3 KIIAFYLPQFHSI----------------------PENDEWWGKgfTEWTNTkkamPLYKNHYQ-------PKL----PY 49
Cdd:COG3754    5 ALFAFYLPQADELlltndsifgpiaplsplfdrmePENDDWWGL--GEWTNK----PLFPGHLQsyflvfrKRAlaspAF 78
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 504122490  50 GNNYYNLLNKE-----TRLWQAKLAMEHGVYGFCyYHYWFNGKMLLNKPLEEVLK--LNEPELPF 107
Cdd:COG3754   79 RDFWYDLRLIEdkddvIRRYEAGLARALGIAGFC-YHYWFDGKRLRTRLLERPWDelLENGGFPF 142
 
Name Accession Description Interval E-value
Glyco_tran_WbsX cd11579
Glycosyl hydrolase family 99-like domain of WbsX-like glycosyltransferases; Members of this ...
3-357 0e+00

Glycosyl hydrolase family 99-like domain of WbsX-like glycosyltransferases; Members of this domain family are found in proteins within O-antigen biosynthesis clusters in Gram negative bacteria, where they may function as glycosyl hydrolases and typically co-occur with glycosyltransferase domains. They bear resemblance to GH71 and the GH99 family of alpha-1,2-mannosidases and may share a similar cataltyic site and mechanism. The O-antigens are essential lipopolysaccharides in gram-negative bacteria's outer membrane and have been linked to pathogenicity.


Pssm-ID: 211420 [Multi-domain]  Cd Length: 347  Bit Score: 509.39  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504122490   3 KIIAFYLPQFHSIPENDEWWGKGFTEWTNTKKAMPLYKNHYQPKLPYGNNYYNLLNKETRLWQAKLAMEHGVYGFCYYHY 82
Cdd:cd11579    2 KVIAFYLPQFHPIPENDEWWGKGFTEWTNVKKAKPLFEGHYQPRVPLDLGYYDLRDPEVREKQAELAKEYGIDGFCYYHY 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504122490  83 WFNGKMLLNKPLEEVLKLNEPELPFCMCWANEPWTRTWDGGENEILMPQYYGNRDDWQKHFEYLLPFFKDSRYITVDEMP 162
Cdd:cd11579   82 WFGGKRLLEKPLEELLLSGEPDFPFCLCWANENWTRRWDGRDKEELLEQQYYGEEDWKEHFRYLLPYFKDPRYIKIDGKP 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504122490 163 LFLIYKTSLIENCDEMIKYWNELGVKNGLKGIYVAEELTGFQLKPCCKETRAVVEFEPTYTIRENADIFSRLILKIKyll 242
Cdd:cd11579  162 VFLIYRPELIPDPKETLELWRELAREAGLPGLYLVAVASFGIEDPRDLGFDAAVEFPPHYVVASELSKSRKLLKLKK--- 238
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504122490 243 rkkivsGKLIRFYDYDYIWNKIIKRKRKviDKKVFLGAFIDWDNSARKKYEAIIFKGASPQKFEKYIKKQL--MVAKELN 320
Cdd:cd11579  239 ------GFGGNVYDYDDLVKYILNRPDP--DYPYYPGVFPGWDNTPRRGKRGTIFVNSTPELFKKWLRKAIerAKARPED 310
                        330       340       350
                 ....*....|....*....|....*....|....*..
gi 504122490 321 SEFVFLNAWNEWAEGTYLEPDQKYGYAYLEAIKEAQN 357
Cdd:cd11579  311 ERLVFINAWNEWAEGAYLEPDLKYGYGYLEALKEALE 347
Glyco_tran_WbsX pfam14307
Glycosyltransferase WbsX; Members of this family are found in within O-antigen biosynthesis ...
4-352 3.94e-180

Glycosyltransferase WbsX; Members of this family are found in within O-antigen biosynthesis clusters in Gram negative bacteria, where they are predicted to function as glycosyltransferases.


Pssm-ID: 464132 [Multi-domain]  Cd Length: 311  Bit Score: 501.26  E-value: 3.94e-180
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504122490    4 IIAFYLPQFHSIPENDEWWGKGFTEWTNTKKAMPLYKNHYQPKLPYGNNYYNLLNKETRLWQAKLAMEHGVYGFCYYHYW 83
Cdd:pfam14307   1 VIAFYLPQFHPIPENDEWWGKGFTEWTNVKKAKPLFKGHYQPRLPADLGYYDLRLPEVRRAQAELAKEYGIYGFCYYHYW 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504122490   84 FNGKMLLNKPLEEVLKLNEPELPFCMCWANEPWTRTWDGGENEILMPQYYGnRDDWQKHFEYLLPFFKDSRYITVDEMPL 163
Cdd:pfam14307  81 FGGKRLLEKPLEELLESKEPDFPFCLCWANESWTRRWDGSDKEILIEQDYG-EEDDKAHFDYLLPYFKDPRYIKVDGKPL 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504122490  164 FLIYKTSLIENCDEMIKYWNELGVKNGLKGIYVAEELTGFQLKPCCKETRAVVEFeptytirenadifsrlilkikyllr 243
Cdd:pfam14307 160 FLIYRPDLIPDPKETIERWRELAKENGLGGIYLVGVQSFGDEDPRDLGFDAAVEF------------------------- 214
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504122490  244 kkivsgklirfyDYDYIWNKIIKRKRKviDKKVFLGAFIDWDNSARKKYEAIIFKGASPQKFEKYIKKQLMVAKELNSE- 322
Cdd:pfam14307 215 ------------DYDKLVRRILNRPPP--KYKLFPGVFPGWDNTPRRGKRGTIFHGATPEKFEKWLEKAVERAKQKPDEe 280
                         330       340       350
                  ....*....|....*....|....*....|.
gi 504122490  323 -FVFLNAWNEWAEGTYLEPDQKYGYAYLEAI 352
Cdd:pfam14307 281 rIVFINAWNEWAEGAYLEPDLKFGYAYLEAI 311
RgpF COG3754
Lipopolysaccharide biosynthesis protein [Cell wall/membrane/envelope biogenesis];
3-107 2.08e-14

Lipopolysaccharide biosynthesis protein [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442968 [Multi-domain]  Cd Length: 152  Bit Score: 69.70  E-value: 2.08e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504122490   3 KIIAFYLPQFHSI----------------------PENDEWWGKgfTEWTNTkkamPLYKNHYQ-------PKL----PY 49
Cdd:COG3754    5 ALFAFYLPQADELlltndsifgpiaplsplfdrmePENDDWWGL--GEWTNK----PLFPGHLQsyflvfrKRAlaspAF 78
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 504122490  50 GNNYYNLLNKE-----TRLWQAKLAMEHGVYGFCyYHYWFNGKMLLNKPLEEVLK--LNEPELPF 107
Cdd:COG3754   79 RDFWYDLRLIEdkddvIRRYEAGLARALGIAGFC-YHYWFDGKRLRTRLLERPWDelLENGGFPF 142
GH99_GH71_like cd11573
Glycoside hydrolase families 71, 99, and related domains; This superfamily of glycoside ...
42-346 2.49e-12

Glycoside hydrolase families 71, 99, and related domains; This superfamily of glycoside hydrolases contains families GH71 and GH99 (following the CAZY nomenclature), as well as other members with undefined function and specificity.


Pssm-ID: 211414  Cd Length: 284  Bit Score: 66.36  E-value: 2.49e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504122490  42 HYQPKLPygnnyynllnkETRLWQAKLAMEHGVYGFCYYHYWF-------NGKMLLNKPLEEVLKLNEPeLPFCMCWANE 114
Cdd:cd11573    4 GYQPWTP-----------EVMRKHIRWAQEAGIDGFAVDWYPEadtsplaETTAILNKALDAAEEENFT-IFFMLDPASL 71
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504122490 115 PWTRTWD-GGENEILMPQYYGNRddwqkhfeyllpffkdSRYITVDEMPLFLIYKTSLIENCDEmikyWNELGVKNGLKG 193
Cdd:cd11573   72 REAGELDvVLERITRLINEYRNP----------------SSYYKVGGKPLVFIWGPGLAYTASE----WEALKAQLRAGC 131
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504122490 194 IYVAEELTGFQLKpccKETRAVVEFEPTYTIRENadifsrlilkikYLLRKKIVSGKLIRFYDYDYIWnkiikrkRKVID 273
Cdd:cd11573  132 PYMIGLWTPWRVP---NRDMITDMFDGASPWTPW------------RGTNPEEAYGHGVKNWRPDQEW-------MGANG 189
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 504122490 274 KKVFLGAFIDWDNSARKKYEAIIFK-GASPQKFekyiKKQLMVAKELNSEFVFLNAWNEWAEGTYLEPDQKYGY 346
Cdd:cd11573  190 KGYIPTVSPGFSDINRRPGDPGDIIlRRDGQRL----HSMLEAALKAGPAMIQIASWNDWGEGTYIEPCEEYGP 259
GH99_GH71_like_3 cd11575
Uncharacterized glycoside hydrolase family 99-like domain; This family of putative glycoside ...
316-354 1.67e-03

Uncharacterized glycoside hydrolase family 99-like domain; This family of putative glycoside hydrolases resembles glycosyl hydrolase families 71 and 99 (following the CAZY nomenclature) and may share a similar catalytic site and mechanism.


Pssm-ID: 211416  Cd Length: 376  Bit Score: 40.01  E-value: 1.67e-03
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 504122490 316 AKELNSEFVFLNAWNEWAEGTYLEPDQKYGYAYLEAIKE 354
Cdd:cd11575  285 ALASGLDIIQIATWNDYGEGTMIEPTVEFGYRDLETTQQ 323
GH99_GH71_like_1 cd11578
Uncharacterized glycoside hydrolase family 99-like domain; This family of putative glycoside ...
306-354 4.98e-03

Uncharacterized glycoside hydrolase family 99-like domain; This family of putative glycoside hydrolases resembles glycosyl hydrolase families 71 and 99 (following the CAZY nomenclature) and may share a similar catalytic site and mechanism.


Pssm-ID: 211419  Cd Length: 313  Bit Score: 38.55  E-value: 4.98e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 504122490 306 EKYIKKQLMVAKEL--NSEFVFLNAWNEWAEGTYLEP-DQKYGYAYLEAIKE 354
Cdd:cd11578  256 PSSFKKMCNVALRNdgACNIVLITSFNEWNEGTNIEPsEEAYGFGYLETLLD 307
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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