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Conserved domains on  [gi|504199070|ref|WP_014386172|]
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MULTISPECIES: NAD(P)/FAD-dependent oxidoreductase [Klebsiella]

Protein Classification

flavin-containing monooxygenase( domain architecture ID 11449697)

flavin-containing monooxygenase (FMO) catalyses the flavin-dependent oxidation of ketones and cyclic ketones to esters and lactones, by using molecular oxygen and NAD(P)H.

CATH:  3.50.50.60
Gene Ontology:  GO:0016709|GO:0004497|GO:0050660
PubMed:  20015679|33588053

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CzcO COG2072
Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ...
 1-405 1.96e-84

Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ion transport and metabolism];


:

Pssm-ID: 441675 [Multi-domain]  Cd Length: 414  Bit Score: 264.03  E-value: 1.96e-84
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504199070   1 MSVEKINTVIVGAGQAGIAMSEHLAQMGVPHVVLER-SRIAERWRSERWDSLVANGPAWHDRFPSLKFDNiSQEAFPPKE 79
Cdd:COG2072    2 AATEHVDVVVIGAGQAGLAAAYHLRRAGIDFVVLEKaDDVGGTWRDNRYPGLRLDTPSHLYSLPFFPNWS-DDPDFPTGD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504199070  80 RMAQYFEDYAKM--LDAPVRTGVEVHQVVRLLGRSGFKVVTSAGE-FEADNVVAATGPFQKPSFPQIVP-ETTGLQQIHS 155
Cdd:COG2072   81 EILAYLEAYADKfgLRRPIRFGTEVTSARWDEADGRWTVTTDDGEtLTARFVVVATGPLSRPKIPDIPGlEDFAGEQLHS 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504199070 156 SAYKNPQQLPAGGVLVVGAGASGTQIAEELRKSGREVYLSVGEHYR-------PPRAYRNRDY-----CWWLGALGLWDE 223
Cdd:COG2072  161 ADWRNPVDLAGKRVLVVGTGASAVQIAPELARVAAHVTVFQRTPPWvlprpnyDPERGRPANYlgleaPPALNRRDARAW 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504199070 224 VkikpkKEHVAFAVSGYEGGK-TVDFRRLAHMGITlvgitkswDNGVLSFaeglaenIAEGDkayFDVLRDADAYIERNG 302
Cdd:COG2072  241 L-----RRLLRAQVKDPELGLlTPDYPPGCKRPLL--------STDYYEA-------LRRGN---VELVTGGIERITEDG 297

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504199070 303 LdlppepqaweLLPDPEcllhpltqldiaEAGITSIIWATGFKFDFSWLQV-DAFDEKGL--PFHKRGISAER--GIYFL 377
Cdd:COG2072  298 V----------VFADGT------------EHEVDVIVWATGFRADLPWLAPlDVRGRDGRsgPRAYLGVVVPGfpNLFFL 355

                        410       420
                 ....*....|....*....|....*...
gi 504199070 378 GLPNLVNRaSSFIYGVWHDAKYIADHIA 405
Cdd:COG2072  356 GPNSPSGH-SSLTLGAERQARYIARLIA 382
 
Name Accession Description Interval E-value
CzcO COG2072
Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ...
 1-405 1.96e-84

Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ion transport and metabolism];


Pssm-ID: 441675 [Multi-domain]  Cd Length: 414  Bit Score: 264.03  E-value: 1.96e-84
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504199070   1 MSVEKINTVIVGAGQAGIAMSEHLAQMGVPHVVLER-SRIAERWRSERWDSLVANGPAWHDRFPSLKFDNiSQEAFPPKE 79
Cdd:COG2072    2 AATEHVDVVVIGAGQAGLAAAYHLRRAGIDFVVLEKaDDVGGTWRDNRYPGLRLDTPSHLYSLPFFPNWS-DDPDFPTGD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504199070  80 RMAQYFEDYAKM--LDAPVRTGVEVHQVVRLLGRSGFKVVTSAGE-FEADNVVAATGPFQKPSFPQIVP-ETTGLQQIHS 155
Cdd:COG2072   81 EILAYLEAYADKfgLRRPIRFGTEVTSARWDEADGRWTVTTDDGEtLTARFVVVATGPLSRPKIPDIPGlEDFAGEQLHS 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504199070 156 SAYKNPQQLPAGGVLVVGAGASGTQIAEELRKSGREVYLSVGEHYR-------PPRAYRNRDY-----CWWLGALGLWDE 223
Cdd:COG2072  161 ADWRNPVDLAGKRVLVVGTGASAVQIAPELARVAAHVTVFQRTPPWvlprpnyDPERGRPANYlgleaPPALNRRDARAW 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504199070 224 VkikpkKEHVAFAVSGYEGGK-TVDFRRLAHMGITlvgitkswDNGVLSFaeglaenIAEGDkayFDVLRDADAYIERNG 302
Cdd:COG2072  241 L-----RRLLRAQVKDPELGLlTPDYPPGCKRPLL--------STDYYEA-------LRRGN---VELVTGGIERITEDG 297

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504199070 303 LdlppepqaweLLPDPEcllhpltqldiaEAGITSIIWATGFKFDFSWLQV-DAFDEKGL--PFHKRGISAER--GIYFL 377
Cdd:COG2072  298 V----------VFADGT------------EHEVDVIVWATGFRADLPWLAPlDVRGRDGRsgPRAYLGVVVPGfpNLFFL 355

                        410       420
                 ....*....|....*....|....*...
gi 504199070 378 GLPNLVNRaSSFIYGVWHDAKYIADHIA 405
Cdd:COG2072  356 GPNSPSGH-SSLTLGAERQARYIARLIA 382
Pyr_redox_3 pfam13738
Pyridine nucleotide-disulphide oxidoreductase;
16-215 1.72e-21

Pyridine nucleotide-disulphide oxidoreductase;


Pssm-ID: 404603 [Multi-domain]  Cd Length: 296  Bit Score: 93.83  E-value: 1.72e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504199070   16 AGIAMSEHLAQMGV-PHVVLERSRIAERWRseRW--------DSLVANGPAWHD---RFPSLKFDNISQEAFPPKERMAQ 83
Cdd:pfam13738   2 AGIGCAIALKKAGLeDYLILEKGNIGNSFY--RYpthmtffsPSFTSNGFGIPDlnaISPGTSPAFTFNREHPSGNEYAE 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504199070   84 YFEDYAKMLDAPVRTGVEVHQVVRllGRSGFKVVTSAGEFEADNVVAATGPFQKPSFPqIVPETTglqqIHSSAYKNPQQ 163
Cdd:pfam13738  80 YLRRVADHFELPINLFEEVTSVKK--EDDGFVVTTSKGTYQARYVIIATGEFDFPNKL-GVPELP----KHYSYVKDFHP 152

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 504199070  164 LPAGGVLVVGAGASGTQIAEELRKSGREVYLSVGehyRPPRAYRNRDYCWWL 215
Cdd:pfam13738 153 YAGQKVVVIGGYNSAVDAALELVRKGARVTVLYR---GSEWEDRDSDPSYSL 201
PLN02172 PLN02172
flavin-containing monooxygenase FMO GS-OX
 7-195 3.42e-09

flavin-containing monooxygenase FMO GS-OX


Pssm-ID: 215116 [Multi-domain]  Cd Length: 461  Bit Score: 58.33  E-value: 3.42e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504199070   7 NTVIVGAGQAGIAMSEHLAQMGVPHVVLER-SRIAERW--------------------RSERWDSLVANGP----AWHDr 61
Cdd:PLN02172  12 HVAVIGAGAAGLVAARELRREGHTVVVFEReKQVGGLWvytpksesdplsldptrsivHSSVYESLRTNLPrecmGYRD- 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504199070  62 FPSL-KFDNISQEA--FPPKERMAQYFEDYAK--MLDAPVRTGVEVHQVVRLLGRSGFKVVTSAGEFEA---DNVVAATG 133
Cdd:PLN02172  91 FPFVpRFDDESRDSrrYPSHREVLAYLQDFARefKIEEMVRFETEVVRVEPVDGKWRVQSKNSGGFSKDeifDAVVVCNG 170

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 504199070 134 PFQKPSFPQIvP--ETTGLQQIHSSAYKNPQQLPAGGVLVVGAGASGTQIAEELRKSGREVYLS 195
Cdd:PLN02172 171 HYTEPNVAHI-PgiKSWPGKQIHSHNYRVPDPFKNEVVVVIGNFASGADISRDIAKVAKEVHIA 233
 
Name Accession Description Interval E-value
CzcO COG2072
Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ...
 1-405 1.96e-84

Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ion transport and metabolism];


Pssm-ID: 441675 [Multi-domain]  Cd Length: 414  Bit Score: 264.03  E-value: 1.96e-84
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504199070   1 MSVEKINTVIVGAGQAGIAMSEHLAQMGVPHVVLER-SRIAERWRSERWDSLVANGPAWHDRFPSLKFDNiSQEAFPPKE 79
Cdd:COG2072    2 AATEHVDVVVIGAGQAGLAAAYHLRRAGIDFVVLEKaDDVGGTWRDNRYPGLRLDTPSHLYSLPFFPNWS-DDPDFPTGD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504199070  80 RMAQYFEDYAKM--LDAPVRTGVEVHQVVRLLGRSGFKVVTSAGE-FEADNVVAATGPFQKPSFPQIVP-ETTGLQQIHS 155
Cdd:COG2072   81 EILAYLEAYADKfgLRRPIRFGTEVTSARWDEADGRWTVTTDDGEtLTARFVVVATGPLSRPKIPDIPGlEDFAGEQLHS 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504199070 156 SAYKNPQQLPAGGVLVVGAGASGTQIAEELRKSGREVYLSVGEHYR-------PPRAYRNRDY-----CWWLGALGLWDE 223
Cdd:COG2072  161 ADWRNPVDLAGKRVLVVGTGASAVQIAPELARVAAHVTVFQRTPPWvlprpnyDPERGRPANYlgleaPPALNRRDARAW 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504199070 224 VkikpkKEHVAFAVSGYEGGK-TVDFRRLAHMGITlvgitkswDNGVLSFaeglaenIAEGDkayFDVLRDADAYIERNG 302
Cdd:COG2072  241 L-----RRLLRAQVKDPELGLlTPDYPPGCKRPLL--------STDYYEA-------LRRGN---VELVTGGIERITEDG 297

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504199070 303 LdlppepqaweLLPDPEcllhpltqldiaEAGITSIIWATGFKFDFSWLQV-DAFDEKGL--PFHKRGISAER--GIYFL 377
Cdd:COG2072  298 V----------VFADGT------------EHEVDVIVWATGFRADLPWLAPlDVRGRDGRsgPRAYLGVVVPGfpNLFFL 355

                        410       420
                 ....*....|....*....|....*...
gi 504199070 378 GLPNLVNRaSSFIYGVWHDAKYIADHIA 405
Cdd:COG2072  356 GPNSPSGH-SSLTLGAERQARYIARLIA 382
Pyr_redox_3 pfam13738
Pyridine nucleotide-disulphide oxidoreductase;
16-215 1.72e-21

Pyridine nucleotide-disulphide oxidoreductase;


Pssm-ID: 404603 [Multi-domain]  Cd Length: 296  Bit Score: 93.83  E-value: 1.72e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504199070   16 AGIAMSEHLAQMGV-PHVVLERSRIAERWRseRW--------DSLVANGPAWHD---RFPSLKFDNISQEAFPPKERMAQ 83
Cdd:pfam13738   2 AGIGCAIALKKAGLeDYLILEKGNIGNSFY--RYpthmtffsPSFTSNGFGIPDlnaISPGTSPAFTFNREHPSGNEYAE 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504199070   84 YFEDYAKMLDAPVRTGVEVHQVVRllGRSGFKVVTSAGEFEADNVVAATGPFQKPSFPqIVPETTglqqIHSSAYKNPQQ 163
Cdd:pfam13738  80 YLRRVADHFELPINLFEEVTSVKK--EDDGFVVTTSKGTYQARYVIIATGEFDFPNKL-GVPELP----KHYSYVKDFHP 152

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 504199070  164 LPAGGVLVVGAGASGTQIAEELRKSGREVYLSVGehyRPPRAYRNRDYCWWL 215
Cdd:pfam13738 153 YAGQKVVVIGGYNSAVDAALELVRKGARVTVLYR---GSEWEDRDSDPSYSL 201
NAD_binding_9 pfam13454
FAD-NAD(P)-binding;
9-135 5.81e-10

FAD-NAD(P)-binding;


Pssm-ID: 433222 [Multi-domain]  Cd Length: 155  Bit Score: 57.67  E-value: 5.81e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504199070    9 VIVGAGQAGIAMSEHLAQMGVPH----VVLERSRIAER--WRSERWDSLVANGPA-----WHDRFPSL-----------K 66
Cdd:pfam13454   1 AIVGGGPSGLALLERLLARAPKRpleiTLFDPSPPGAGgvYRTDQSPEHLLNVPAsrmslFPDDPPHFlewlrargaldE 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 504199070   67 FDNISQEAFPPKERMAQYFEDYAKML--DAPVRTGVEVHQ--VVRLLGR-SGFKVVTSAG-EFEADNVVAATGPF 135
Cdd:pfam13454  81 APGLDPDDFPPRALYGRYLRDRFEEAlaRAPAGVTVRVHRarVTDLRPRgDGYRVLLADGrTLAADAVVLATGHG 155
Pyr_redox_2 pfam07992
Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II ...
 9-194 1.55e-09

Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II oxidoreductases and also NADH oxidases and peroxidases. This domain is actually a small NADH binding domain within a larger FAD binding domain.


Pssm-ID: 400379 [Multi-domain]  Cd Length: 301  Bit Score: 58.87  E-value: 1.55e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504199070    9 VIVGAGQAGIAMSEHLAQMGVPHVVLERSRIaerwrserwdsLVANGPAwhdrfPSLKFDNisqEAFPPKErmAQYFEDY 88
Cdd:pfam07992   4 VVIGGGPAGLAAALTLAQLGGKVTLIEDEGT-----------CPYGGCV-----LSKALLG---AAEAPEI--ASLWADL 62

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504199070   89 AKMLDAPVRTgvEVHQVVRLLGRSGFKVVTSAGEF-------------EADNVVAATG--PFqKPSFPQIVPETTGLQQI 153
Cdd:pfam07992  63 YKRKEEVVKK--LNNGIEVLLGTEVVSIDPGAKKVvleelvdgdgetiTYDRLVIATGarPR-LPPIPGVELNVGFLVRT 139

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 504199070  154 HSSAYKNPQQLPAGGVLVVGAGASGTQIAEELRKSGREVYL 194
Cdd:pfam07992 140 LDSAEALRLKLLPKRVVVVGGGYIGVELAAALAKLGKEVTL 180
PLN02172 PLN02172
flavin-containing monooxygenase FMO GS-OX
 7-195 3.42e-09

flavin-containing monooxygenase FMO GS-OX


Pssm-ID: 215116 [Multi-domain]  Cd Length: 461  Bit Score: 58.33  E-value: 3.42e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504199070   7 NTVIVGAGQAGIAMSEHLAQMGVPHVVLER-SRIAERW--------------------RSERWDSLVANGP----AWHDr 61
Cdd:PLN02172  12 HVAVIGAGAAGLVAARELRREGHTVVVFEReKQVGGLWvytpksesdplsldptrsivHSSVYESLRTNLPrecmGYRD- 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504199070  62 FPSL-KFDNISQEA--FPPKERMAQYFEDYAK--MLDAPVRTGVEVHQVVRLLGRSGFKVVTSAGEFEA---DNVVAATG 133
Cdd:PLN02172  91 FPFVpRFDDESRDSrrYPSHREVLAYLQDFARefKIEEMVRFETEVVRVEPVDGKWRVQSKNSGGFSKDeifDAVVVCNG 170

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 504199070 134 PFQKPSFPQIvP--ETTGLQQIHSSAYKNPQQLPAGGVLVVGAGASGTQIAEELRKSGREVYLS 195
Cdd:PLN02172 171 HYTEPNVAHI-PgiKSWPGKQIHSHNYRVPDPFKNEVVVVIGNFASGADISRDIAKVAKEVHIA 233
YdhS COG4529
Uncharacterized NAD(P)/FAD-binding protein YdhS [General function prediction only];
1-177 4.34e-09

Uncharacterized NAD(P)/FAD-binding protein YdhS [General function prediction only];


Pssm-ID: 443597 [Multi-domain]  Cd Length: 466  Bit Score: 58.04  E-value: 4.34e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504199070   1 MSVEKINTVIVGAGQAGIAMSEHLAQMGVPH---VVLERSriAERWR----SERWDSLVANGPA---------------W 58
Cdd:COG4529    1 MTGARKRIAIIGGGASGTALAIHLLRRAPEPlriTLFEPR--PELGRgvaySTDSPEHLLNVPAgrmsafpddpdhflrW 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504199070  59 HDRFPSLKFDNISQEAFPPKERMAQYFEDYAKML--DAPVRTGVEVHQ--VVRL-LGRSGFKVVTSAGE-FEADNVVAAT 132
Cdd:COG4529   79 LRENGARAAPAIDPDAFVPRRLFGEYLRERLAEAlaRAPAGVRLRHIRaeVVDLeRDDGGYRVTLADGEtLRADAVVLAT 158

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 504199070 133 GPFQKPSFPQIVPETTGLqqiHSSAYKnPQQL----PAGGVLVVGAGAS 177
Cdd:COG4529  159 GHPPPAPPPGLAAGSPRY---IADPWP-PGALaripPDARVLIIGTGLT 203
FMO-like pfam00743
Flavin-binding monooxygenase-like; This family includes FMO proteins, cyclohexanone ...
 10-195 1.15e-07

Flavin-binding monooxygenase-like; This family includes FMO proteins, cyclohexanone mono-oxygenase and a number of different mono-oxygenases.


Pssm-ID: 395602 [Multi-domain]  Cd Length: 531  Bit Score: 53.63  E-value: 1.15e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504199070   10 IVGAGQAGIAMSEHLAQMGVPHVVLERSR-IAERW---------RSERWDSLVANGPAWHDRFPSLKFdnisQEAFP--- 76
Cdd:pfam00743   6 VIGAGVSGLASIKCCLEEGLEPTCFERSDdIGGLWrftenveegRASIYKSVITNTSKEMSCFSDFPF----PEDYPnfm 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504199070   77 PKERMAQYFEDYAKMLD--APVRTGVEVHQVVRL--LGRSG-FKVVT-SAGEFEA---DNVVAATGPFQKP-----SFPQ 142
Cdd:pfam00743  82 HNSKFLEYFRMFAKEFDllKYIQFKTTVCSVKKRpdFSTSGqWEVVTeHEGKQESavfDAVMVCTGHHTNPhlpleSFPG 161

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 504199070  143 IvpETTGLQQIHSSAYKNPQQLPAGGVLVVGAGASGTQIAEELRKSGREVYLS 195
Cdd:pfam00743 162 I--EKFKGQYFHSRDYKHPEGFTGKRVLVIGIGNSGGDIAVELSHTAAQVFLS 212
Lys_Orn_oxgnase pfam13434
L-lysine 6-monooxygenase/L-ornithine 5-monooxygenase; This is a family of Rossmann fold ...
 59-185 5.55e-07

L-lysine 6-monooxygenase/L-ornithine 5-monooxygenase; This is a family of Rossmann fold oxidoreductases that catalyze NADPH-dependent hydroxylation and are involved in siderophore biosynthesis. This family includes L-ornithine 5-monooxygenase, which catalyzes the hydroxylation of L-ornithine at the N5 position, and L-lysine 6-monooxygenase, which catalyzes the hydroxylation of lysine at the N6 position (EC:1.14.13.59).


Pssm-ID: 433204 [Multi-domain]  Cd Length: 338  Bit Score: 51.05  E-value: 5.55e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504199070   59 HDRFPSlkFDNISQEAFPPKErmaqyFEDY----AKMLDAPVRTGVEVHQV--VRLLGRSGFKVVTS-----AGEFEADN 127
Cdd:pfam13434  78 HGRLYS--FYNLETFFPSRRE-----FNDYlqwaASHLPNRLRFGQEVESVepDAERGEPLLRVRVRdadgeETTFLARN 150

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 504199070  128 VVAATGPfqKPSFPQIVPetTGLQQIHSSAY--KNPQQLPAGGVLVVGAGASGTQIAEEL 185
Cdd:pfam13434 151 LVLGTGG--EPYIPECAR--GGERVFHSSEYleRIDRLAAKKRIAVVGSGQSAAEIFRDL 206
TrxB COG0492
Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones];
9-194 4.58e-05

Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440258 [Multi-domain]  Cd Length: 305  Bit Score: 45.11  E-value: 4.58e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504199070   9 VIVGAGQAGIAMSEHLAQMGVPHVVLERSRIAER-WRSERwdslVANGPAwhdrFPslkfDNISQEAfppkerMAQYFED 87
Cdd:COG0492    4 VIIGAGPAGLTAAIYAARAGLKTLVIEGGEPGGQlATTKE----IENYPG----FP----EGISGPE------LAERLRE 65

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504199070  88 YAKMLDAPVRTGvEVHQVVRllGRSGFKVVTSAG-EFEADNVVAATG--PfQKPSFPqivpettGLQQ-----IHSSAYK 159
Cdd:COG0492   66 QAERFGAEILLE-EVTSVDK--DDGPFRVTTDDGtEYEAKAVIIATGagP-RKLGLP-------GEEEfegrgVSYCATC 134

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 504199070 160 NPQQLPAGGVLVVGAGASGTQIAEELRKSGREVYL 194
Cdd:COG0492  135 DGFFFRGKDVVVVGGGDSALEEALYLTKFASKVTL 169
DadA COG0665
Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];
22-214 2.65e-04

Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];


Pssm-ID: 440429 [Multi-domain]  Cd Length: 364  Bit Score: 42.97  E-value: 2.65e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504199070  22 EHLAQMGVPHVVLERSRIAERWRSERWDSLVAngpAWHDRfpslkfdnisQEAF--PPKerMAQYFEDYAKMLDAPVRTG 99
Cdd:COG0665  107 EALRALGLPVELLDAAELREREPGLGSPDYAG---GLYDP----------DDGHvdPAK--LVRALARAARAAGVRIREG 171

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504199070 100 VEVHQVVRLlGRSGFKVVTSAGEFEADNVVAATGPFQKPSFPQI---VP-ETTGLQQIHSSAYKNPQQLP---------- 165
Cdd:COG0665  172 TPVTGLERE-GGRVTGVRTERGTVRADAVVLAAGAWSARLLPMLglrLPlRPVRGYVLVTEPLPDLPLRPvlddtgvylr 250

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 504199070 166 --AGGVLVVGAGASGTQIAEELRKSGREVYLSVGEHYRPPRAYRNRDYCWW 214
Cdd:COG0665  251 ptADGRLLVGGTAEPAGFDRAPTPERLEALLRRLRRLFPALADAEIVRAWA 301
FixC COG0644
Dehydrogenase (flavoprotein) [Energy production and conversion];
13-134 5.00e-03

Dehydrogenase (flavoprotein) [Energy production and conversion];


Pssm-ID: 440409 [Multi-domain]  Cd Length: 281  Bit Score: 38.41  E-value: 5.00e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504199070  13 AGQAGIAMSEHLAQMGVPHVVLERS--------------RIAERWRSERWDSLVANgPAWHDRF--PSLKFDNISQEAFP 76
Cdd:COG0644    1 AGPAGSAAARRLARAGLSVLLLEKGsfpgdkicgggllpRALEELEPLGLDEPLER-PVRGARFysPGGKSVELPPGRGG 79

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 504199070  77 ----PKERMAQYFEDYAKMLDAPVRTGVEVHQVVRLLGRsgFKVVTSAG-EFEADNVVAATGP 134
Cdd:COG0644   80 gyvvDRARFDRWLAEQAEEAGAEVRTGTRVTDVLRDDGR--VVVRTGDGeEIRADYVVDADGA 140
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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