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Conserved domains on  [gi|504233627|ref|WP_014420729|]
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phosphatase PAP2 family protein [Marinobacter nauticus]

Protein Classification

PgpB family protein( domain architecture ID 11430553)

PgpB family protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PgpB COG0671
Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; ...
 1-180 2.29e-19

Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; Membrane-associated phospholipid phosphatase is part of the Pathway/BioSystem: Phospholipid biosynthesis


:

Pssm-ID: 440435 [Multi-domain]  Cd Length: 189  Bit Score: 80.85  E-value: 2.29e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504233627   1 MALTSKASRFFELADQREFAVCQAINRSVRFRPILGYFRVVSRLGDGWFWYALILSLPFYAGDYGPALALQMALTGLTCT 80
Cdd:COG0671    7 LALLLLLLLLADLLALALLALLLLLALLLLLLLLLALLLILLLLLLLLLLLLLLLLLLLRLLALLLLLLLLAALLLLLLL 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504233627  81 LTYKALKRWLIRERPFIsFPVINCATPPLDRYSFPSGHTLHAVCFQAMLFVALP--ALAWCVLPFTLSVAASRVILGLHY 158
Cdd:COG0671   87 LLLLLLKYLFGRPRPFV-VPDLELLLGTAGGYSFPSGHAAAAFALALVLALLLPrrWLAALLLALALLVGLSRVYLGVHY 165

                        170       180
                 ....*....|....*....|..
gi 504233627 159 PSDVLAGALIGGTMGWASMQWL 180
Cdd:COG0671  166 PSDVLAGALLGLAIALLLLALL 187
 
Name Accession Description Interval E-value
PgpB COG0671
Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; ...
 1-180 2.29e-19

Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; Membrane-associated phospholipid phosphatase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 440435 [Multi-domain]  Cd Length: 189  Bit Score: 80.85  E-value: 2.29e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504233627   1 MALTSKASRFFELADQREFAVCQAINRSVRFRPILGYFRVVSRLGDGWFWYALILSLPFYAGDYGPALALQMALTGLTCT 80
Cdd:COG0671    7 LALLLLLLLLADLLALALLALLLLLALLLLLLLLLALLLILLLLLLLLLLLLLLLLLLLRLLALLLLLLLLAALLLLLLL 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504233627  81 LTYKALKRWLIRERPFIsFPVINCATPPLDRYSFPSGHTLHAVCFQAMLFVALP--ALAWCVLPFTLSVAASRVILGLHY 158
Cdd:COG0671   87 LLLLLLKYLFGRPRPFV-VPDLELLLGTAGGYSFPSGHAAAAFALALVLALLLPrrWLAALLLALALLVGLSRVYLGVHY 165

                        170       180
                 ....*....|....*....|..
gi 504233627 159 PSDVLAGALIGGTMGWASMQWL 180
Cdd:COG0671  166 PSDVLAGALLGLAIALLLLALL 187
PAP2_like_2 cd03392
PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 27-170 1.79e-14

PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239486  Cd Length: 182  Bit Score: 67.63  E-value: 1.79e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504233627  27 RSVRFRPILGYFRVVSRLGDGWFWYALILSLPFYAGDYG-PALALQMALTGLTCTLTYKALKRWLIRERPFISFPVinca 105
Cdd:cd03392   21 RSLRTPLLTAFMTAITFLGSPAVLLIIVLLLALLLLLKRrRRAALFLLLALLGGGALNTLLKLLVQRPRPPLHLLV---- 96

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 504233627 106 tpPLDRYSFPSGHTLHAVCFQAMLFVALP----------ALAWCVLPFTLSVAASRVILGLHYPSDVLAGALIGG 170
Cdd:cd03392   97 --PEGGYSFPSGHAMGATVLYGFLAYLLArrlprrrvriLLLILAAILILLVGLSRLYLGVHYPSDVLAGWLLGL 169
PAP2 pfam01569
PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), ...
 72-180 1.06e-13

PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), Glucose-6-phosphatase EC:3.1.3.9, Phosphatidylglycerophosphatase B EC:3.1.3.27 and bacterial acid phosphatase EC:3.1.3.2. The family also includes a variety of haloperoxidases that function by oxidising halides in the presence of hydrogen peroxide to form the corresponding hypohalous acids.


Pssm-ID: 426329 [Multi-domain]  Cd Length: 124  Bit Score: 64.36  E-value: 1.06e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504233627   72 MALTGLTCTLTYKALKRWLIRERPFISFPVINCATPPLD----RYSFPSGHTLHAVCFQAMLFVALP--------ALAWC 139
Cdd:pfam01569   2 LLLALALAGLLSSVLKDYFGRPRPFFLLLEGGLVPAPSTlpglGYSFPSGHSATAFALALLLALLLRrlrkivrvLLALL 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 504233627  140 VLPFTLSVAASRVILGLHYPSDVLAGALIGGTMGWASMQWL 180
Cdd:pfam01569  82 LLVLALLVGLSRLYLGVHFPSDVLAGALIGILLALLVYRLV 122
acidPPc smart00014
Acid phosphatase homologues;
86-174 1.83e-11

Acid phosphatase homologues;


Pssm-ID: 214471 [Multi-domain]  Cd Length: 116  Bit Score: 58.13  E-value: 1.83e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504233627    86 LKRWLIRERPFISFPVINCATPPLD-----RYSFPSGHTLHAVCFQAMLFVALPA------LAWCVLPFTLSVAASRVIL 154
Cdd:smart00014  14 IKNYFGRPRPFFLSIGDACCTPNFLltleaGYSFPSGHTAFAFAFALFLLLYLPAragrklLIFLLLLLALVVGFSRVYL 93

                           90       100
                   ....*....|....*....|
gi 504233627   155 GLHYPSDVLAGALIGGTMGW 174
Cdd:smart00014  94 GAHWPSDVLAGSLLGILIAA 113
PRK10699 PRK10699
phosphatidylglycerophosphatase B; Provisional
 112-181 5.53e-06

phosphatidylglycerophosphatase B; Provisional


Pssm-ID: 182658  Cd Length: 244  Bit Score: 45.02  E-value: 5.53e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 504233627 112 YSFPSGHTLHAVCFqAMLFVAL--PALAWCVLPFTL----SVAASRVILGLHYPSDVLAGALIGGTMGWASMqWLA 181
Cdd:PRK10699 157 FAFPSGHTMFAASW-ALLAVGLlwPRRRYKTVALLMlwatGVMGSRLLLGMHWPRDLVVATLISWLLVTVAT-WLA 230
 
Name Accession Description Interval E-value
PgpB COG0671
Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; ...
 1-180 2.29e-19

Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; Membrane-associated phospholipid phosphatase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 440435 [Multi-domain]  Cd Length: 189  Bit Score: 80.85  E-value: 2.29e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504233627   1 MALTSKASRFFELADQREFAVCQAINRSVRFRPILGYFRVVSRLGDGWFWYALILSLPFYAGDYGPALALQMALTGLTCT 80
Cdd:COG0671    7 LALLLLLLLLADLLALALLALLLLLALLLLLLLLLALLLILLLLLLLLLLLLLLLLLLLRLLALLLLLLLLAALLLLLLL 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504233627  81 LTYKALKRWLIRERPFIsFPVINCATPPLDRYSFPSGHTLHAVCFQAMLFVALP--ALAWCVLPFTLSVAASRVILGLHY 158
Cdd:COG0671   87 LLLLLLKYLFGRPRPFV-VPDLELLLGTAGGYSFPSGHAAAAFALALVLALLLPrrWLAALLLALALLVGLSRVYLGVHY 165

                        170       180
                 ....*....|....*....|..
gi 504233627 159 PSDVLAGALIGGTMGWASMQWL 180
Cdd:COG0671  166 PSDVLAGALLGLAIALLLLALL 187
PAP2_like_2 cd03392
PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 27-170 1.79e-14

PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239486  Cd Length: 182  Bit Score: 67.63  E-value: 1.79e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504233627  27 RSVRFRPILGYFRVVSRLGDGWFWYALILSLPFYAGDYG-PALALQMALTGLTCTLTYKALKRWLIRERPFISFPVinca 105
Cdd:cd03392   21 RSLRTPLLTAFMTAITFLGSPAVLLIIVLLLALLLLLKRrRRAALFLLLALLGGGALNTLLKLLVQRPRPPLHLLV---- 96

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 504233627 106 tpPLDRYSFPSGHTLHAVCFQAMLFVALP----------ALAWCVLPFTLSVAASRVILGLHYPSDVLAGALIGG 170
Cdd:cd03392   97 --PEGGYSFPSGHAMGATVLYGFLAYLLArrlprrrvriLLLILAAILILLVGLSRLYLGVHYPSDVLAGWLLGL 169
PAP2_like cd01610
PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, ...
 67-175 1.84e-14

PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid phosphatase, vanadium chloroperoxidases, vanadium bromoperoxidases, and several other mostly uncharacterized subfamilies. Several members of this superfamily have been predicted to be transmembrane proteins.


Pssm-ID: 238813 [Multi-domain]  Cd Length: 122  Bit Score: 66.33  E-value: 1.84e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504233627  67 ALALQMALTGLTCTLTYKALKRWLIRERPFISFPVINCATPPL---DRYSFPSGHTLHAVCFQAMLFVALPA------LA 137
Cdd:cd01610    3 LLALLLLLALLAGLLLTGVLKYLFGRPRPYFLLRCGPDGDPLLlteGGYSFPSGHAAFAFALALFLALLLPRrllrllLG 82

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 504233627 138 WCVLPFTLSVAASRVILGLHYPSDVLAGALIGGTMGWA 175
Cdd:cd01610   83 LLLLLLALLVGLSRVYLGVHYPSDVLAGALLGILVALL 120
PAP2_like_4 cd03395
PAP2_like_4 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 48-175 8.16e-14

PAP2_like_4 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239489  Cd Length: 177  Bit Score: 65.75  E-value: 8.16e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504233627  48 WFWYALILSLPFYAGDYGPALALQMALT-GLTCTLTYKALKRWLIRERPfiSFPVINCA----TPPLDRYSFPSGHT--L 120
Cdd:cd03395   37 PIFLLLALFILFRKGPIGLLILLLVLLAvGFADQLASGFLKPLVARLRP--CNALDGVRlvvlGDQGGSYSFASSHAanS 114

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 504233627 121 HAVCFQAMLFVALPALAWCVLPFTLSVAASRVILGLHYPSDVLAGALIGGTMGWA 175
Cdd:cd03395  115 FALALFIWLFFRRGLFSPVLLLWALLVGYSRVYVGVHYPGDVIAGALIGIISGLL 169
PAP2 pfam01569
PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), ...
 72-180 1.06e-13

PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), Glucose-6-phosphatase EC:3.1.3.9, Phosphatidylglycerophosphatase B EC:3.1.3.27 and bacterial acid phosphatase EC:3.1.3.2. The family also includes a variety of haloperoxidases that function by oxidising halides in the presence of hydrogen peroxide to form the corresponding hypohalous acids.


Pssm-ID: 426329 [Multi-domain]  Cd Length: 124  Bit Score: 64.36  E-value: 1.06e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504233627   72 MALTGLTCTLTYKALKRWLIRERPFISFPVINCATPPLD----RYSFPSGHTLHAVCFQAMLFVALP--------ALAWC 139
Cdd:pfam01569   2 LLLALALAGLLSSVLKDYFGRPRPFFLLLEGGLVPAPSTlpglGYSFPSGHSATAFALALLLALLLRrlrkivrvLLALL 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 504233627  140 VLPFTLSVAASRVILGLHYPSDVLAGALIGGTMGWASMQWL 180
Cdd:pfam01569  82 LLVLALLVGLSRLYLGVHFPSDVLAGALIGILLALLVYRLV 122
PAP2_containing_2_like cd03391
PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_2. ...
 31-169 8.25e-12

PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_2. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to eukaryota, lacks functional characterization and may act as a membrane-associated phosphatidic acid phosphatase.


Pssm-ID: 239485 [Multi-domain]  Cd Length: 159  Bit Score: 60.02  E-value: 8.25e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504233627  31 FRPILGYFRVVSRLGDGWFWYALILSLPFYAGdygpALALQMALTGLTCTL-----TYKALKRWLIRERPFISFP-VINC 104
Cdd:cd03391   10 WGPVRPLVKLLELSGHGIPWLAGTISCLWISS----SPAGQEVLVNLLLGLlldiiTVAILKALVRRRRPAYNSPdMLDY 85

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 504233627 105 ATPplDRYSFPSGHTLHAVCFQAMLFVALPA---LAWCVLPFTLSVAASRVILGLHYPSDVLAGALIG 169
Cdd:cd03391   86 VAV--DKYSFPSGHASRAAFVARFLLNHLVLavpLRVLLVLWATVVGISRVLLGRHHVLDVLAGAFLG 151
acidPPc smart00014
Acid phosphatase homologues;
86-174 1.83e-11

Acid phosphatase homologues;


Pssm-ID: 214471 [Multi-domain]  Cd Length: 116  Bit Score: 58.13  E-value: 1.83e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504233627    86 LKRWLIRERPFISFPVINCATPPLD-----RYSFPSGHTLHAVCFQAMLFVALPA------LAWCVLPFTLSVAASRVIL 154
Cdd:smart00014  14 IKNYFGRPRPFFLSIGDACCTPNFLltleaGYSFPSGHTAFAFAFALFLLLYLPAragrklLIFLLLLLALVVGFSRVYL 93

                           90       100
                   ....*....|....*....|
gi 504233627   155 GLHYPSDVLAGALIGGTMGW 174
Cdd:smart00014  94 GAHWPSDVLAGSLLGILIAA 113
PAP2_lipid_A_1_phosphatase cd03389
PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from ...
 113-169 1.25e-10

PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from Francisella novicida selectively dephosphorylates lipid A at the 1-position. Lipid A is the membrane-anchor component of lipopolysaccharides (LPS), the major constituents of the outer membrane in many gram-negative bacteria.


Pssm-ID: 239483  Cd Length: 186  Bit Score: 57.33  E-value: 1.25e-10
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 504233627 113 SFPSGHTLHAVCFQAMLFVALPALAWCVLPFTLSVAASRVILGLHYPSDVLAGALIG 169
Cdd:cd03389  119 SFPSGHSATAGAAAAALALLFPRYRWAFILLALLIAFSRVIVGAHYPSDVIAGSLLG 175
PAP2_like_5 cd03394
PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 113-175 1.53e-09

PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239488 [Multi-domain]  Cd Length: 106  Bit Score: 52.72  E-value: 1.53e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 504233627 113 SFPSGHTLHAVCFQAMLFVALPALAWCVLPFTL--SVAASRVILGLHYPSDVLAGALIGGTMGWA 175
Cdd:cd03394   40 SFPSGHTASAFAAATFLQYRYGWRWYGIPAYALasLVGASRVVANRHWLSDVLAGAAIGILVGYL 104
PAP2_acid_phosphatase cd03397
PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes ...
 55-169 3.73e-09

PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains to be determined.


Pssm-ID: 239491  Cd Length: 232  Bit Score: 53.88  E-value: 3.73e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504233627  55 LSLPFYAGDYGPALALqmALTGLTCTL-----------TYKALKRWLiRERPFISFPVINCaTPPLDRY-----SFPSGH 118
Cdd:cd03397   81 LSFPGAANAFSCALGE--ERTPELYRLlrrvledagsaTYPAKKYYN-RPRPFVLNDEPIC-TPPDESGlakdgSYPSGH 156

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 504233627 119 TLHAVCFQAMLFVALPALAWCVLPFTLSVAASRVILGLHYPSDVLAGALIG 169
Cdd:cd03397  157 TAAGYAWALILAELVPERADEILARGSEYGQSRIVCGVHWPSDVMGGRIMA 207
PAP2_like_3 cd03393
PAP2_like_3 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 57-175 4.07e-07

PAP2_like_3 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria and archaea, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239487 [Multi-domain]  Cd Length: 125  Bit Score: 46.98  E-value: 4.07e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504233627  57 LPFYAGDYGPALALQMALTGLTCTLTYKALKRWLIRERPFISFPVINCATPPLDRYSFPSGHTLHAVCFQA--MLFVALP 134
Cdd:cd03393    3 LSLIYWLVDKRLGRYLGLALCASGYLNAALKEVFKIPRPFTYDGIQAIYEESAGGYGFPSGHAQTSATFWGslMLHVRKK 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 504233627 135 ALAWCVLPFTLSVAASRVILGLHYPSDVLAGALIGGTMGWA 175
Cdd:cd03393   83 WFTLIGVVLVVLISFSRLYLGVHWPSDVIGGVLIGLLVLVL 123
PAP2_wunen cd03384
PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid ...
 111-174 1.19e-06

PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the survival of PGCs and is essential in the migration process of these cells towards the somatic gonadal precursors.


Pssm-ID: 239479  Cd Length: 150  Bit Score: 46.08  E-value: 1.19e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 504233627 111 RYSFPSGHTlhAVCFQAMLFVAL---------------PALAWCVLPFTLSVAASRVILGLHYPSDVLAGALIGGTMGW 174
Cdd:cd03384   71 RLSFPSGHA--SLSMYAAVFLALylqarlklrgsrllrPLLQFLLLALALYVGLSRISDYKHHWSDVLAGALLGSVIAL 147
PAP2_SPPase1 cd03388
PAP2_like proteins, sphingosine-1-phosphatase subfamily. Sphingosine-1-phosphatase is an ...
 37-169 1.27e-06

PAP2_like proteins, sphingosine-1-phosphatase subfamily. Sphingosine-1-phosphatase is an intracellular enzyme located in the endoplasmic reticulum, which regulates the level of sphingosine-1-phosphate (S1P), a bioactive lipid. S1P acts as a second messenger in the cell, and extracellularly by binding to G-protein coupled receptors of the endothelial differentiation gene family.


Pssm-ID: 239482  Cd Length: 151  Bit Score: 46.07  E-value: 1.27e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504233627  37 YFRVVSRLGDGWFwYALILSLPFYAGDygPALALQMALTGLTCTLTYKALKRWLIRERPfisfpvincATPPLDR----- 111
Cdd:cd03388    6 YFAFTALLGTHTF-YILFLPFLFWNGD--PYVGRDLVVVLALGMYIGQFIKDLFCLPRP---------SSPPVVRltmss 73

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504233627 112 ----YSFPSGHTLHAVCFQAMLFVAL------PALAWCVLP--FTLSVAASRVILGLHYPSDVLAGALIG 169
Cdd:cd03388   74 aaleYGFPSTHAMNATAISFYLLIYLydryqyPFVLGLILAlfYSTLVCLSRIYMGMHSVLDVIAGSLIG 143
PAP2_BcrC_like cd03385
PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as ...
 94-178 1.55e-06

PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from Bacillus subtilis posesses undecaprenyl pyrophosphate (UPP) phospatase activity, and it is hypothesized that it competes with bacitracin for UPP, increasing the cell's resistance to bacitracin.


Pssm-ID: 239480  Cd Length: 144  Bit Score: 45.71  E-value: 1.55e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504233627  94 RPFISFPVINCATPPLDRySFPSGHTL--HAVCFqAMLFVALPALAWCVLPFTLSVAASRVILGLHYPSDVLAGALIGGT 171
Cdd:cd03385   60 RPFVVGLGHNLLPHAADS-SFPSDHTTlfFSIAF-SLLLRRRKWAGWILLILALLVAWSRIYLGVHYPLDMLGAALVAVL 137


                 ....*..
gi 504233627 172 MGWASMQ 178
Cdd:cd03385  138 SALLVFQ 144
PAP2_like_1 cd03380
PAP2_like_1 proteins, a sub-family of PAP2, containing bacterial acid phosphatase, vanadium ...
 39-173 3.18e-06

PAP2_like_1 proteins, a sub-family of PAP2, containing bacterial acid phosphatase, vanadium chloroperoxidases and vanadium bromoperoxidases.


Pssm-ID: 239475  Cd Length: 209  Bit Score: 45.50  E-value: 3.18e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504233627  39 RVVSRLGDGWFWYALILSLPFYAGDYGPALALQmALTGLTCTLTYKALKRWLIRE--------------RPFISFPVINC 104
Cdd:cd03380   52 RTTAQTALAAFDADGGDPPPHYANAFSIALGTP-GLSEERTPRLYALLARALTDAgiatwdakyhynrpRPFVAIRLQWL 130

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 504233627 105 ATPPLDRY-----SFPSGHTlhavCFQAMLFVAL----PALAWCVLPFTLSVAASRVILGLHYPSDVLAGALIGGTMG 173
Cdd:cd03380  131 PICTPEEGtpkhpSYPSGHA----TFGGAAALVLaelfPERAAELLARAAEAGNSRVVAGVHWPSDVEAGRILGEAIA 204
PRK10699 PRK10699
phosphatidylglycerophosphatase B; Provisional
 112-181 5.53e-06

phosphatidylglycerophosphatase B; Provisional


Pssm-ID: 182658  Cd Length: 244  Bit Score: 45.02  E-value: 5.53e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 504233627 112 YSFPSGHTLHAVCFqAMLFVAL--PALAWCVLPFTL----SVAASRVILGLHYPSDVLAGALIGGTMGWASMqWLA 181
Cdd:PRK10699 157 FAFPSGHTMFAASW-ALLAVGLlwPRRRYKTVALLMlwatGVMGSRLLLGMHWPRDLVVATLISWLLVTVAT-WLA 230
PAP2_containing_1_like cd03390
PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. ...
 46-176 1.29e-05

PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. Most likely membrane-associated phosphatidic acid phosphatases. Plant members of this group are constitutively expressed in many tissues and exhibit both diacylglycerol pyrophosphate phosphatase activity as well as phosphatidate (PA) phosphatase activity, they may have a more generic housekeeping role in lipid metabolism.


Pssm-ID: 239484 [Multi-domain]  Cd Length: 193  Bit Score: 43.75  E-value: 1.29e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504233627  46 DGWFWYALILSLPFyagdygpALALQMALTGLtctltykaLKRWLIRERP-FIS-------------FPVINCATPPLD- 110
Cdd:cd03390   40 SLWDLHTSLLGLLL-------SVSLNGVITNV--------LKNYAGRPRPdFLArcfpdggtpsdtlVGIDICCTGDPGv 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504233627 111 ----RYSFPSGHTlhAVCFQAMLFVAL----------PA-----LAWCVLPFTLS--VAASRVILGLHYPSDVLAGALIG 169
Cdd:cd03390  105 lkegRKSFPSGHS--SFAFAGLGFLSLylagklhifdPRgsswrLLLALLPLLLAilVAVSRTRDYRHHFSDVIAGSLIG 182


                 ....*..
gi 504233627 170 GTMGWAS 176
Cdd:cd03390  183 LIIAYLS 189
PLN02525 PLN02525
phosphatidic acid phosphatase family protein
 50-169 1.58e-05

phosphatidic acid phosphatase family protein


Pssm-ID: 215288  Cd Length: 352  Bit Score: 43.96  E-value: 1.58e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504233627  50 WYALILSLPFYAGDygPALALQMALTGLTCTLTYKALKRWLIRERPfisfpvincATPPLDR-------------YSFPS 116
Cdd:PLN02525  20 FYTAFLPLLFWSGH--GKLARQMTLLMAFCDYVGNCIKDVVSAPRP---------SCPPVRRvtatkdeeenameYGLPS 88

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 504233627 117 GHTLHAVCFQAMLF-------------VALPALAWCVLPFTLsVAASRVILGLHYPSDVLAGALIG 169
Cdd:PLN02525  89 SHTLNTVCLSGYLLhyvlsylqnvdasVIFAGLALFCLLVAL-VGFGRLYLGMHSPIDIIAGLAIG 153
PAP2_dolichyldiphosphatase cd03382
PAP2_like proteins, dolichyldiphosphatase subfamily. Dolichyldiphosphatase is a ...
 77-173 6.06e-04

PAP2_like proteins, dolichyldiphosphatase subfamily. Dolichyldiphosphatase is a membrane-associated protein located in the endoplasmic reticulum and hydrolyzes dolichyl pyrophosphate, as well as dolichylmonophosphate at a low rate. The enzyme is necessary for maintaining proper levels of dolichol-linked oligosaccharides and protein N-glycosylation, and might play a role in re-utilization of the glycosyl carrier lipid for additional rounds of lipid intermediate biosynthesis after its release during protein N-glycosylation reactions.


Pssm-ID: 239477  Cd Length: 159  Bit Score: 38.41  E-value: 6.06e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504233627  77 LTCTLTYKALKRWLIRERPfisfpvINCATPPLDRYSFPSGHTLHAVCFQAMLF-------------VALPALAWCVLPF 143
Cdd:cd03382   52 LANEALNYVLKRIIKEPRP------CSGAYFVRSGYGMPSSHSQFMGFFAVYLLlfiylrlgrlnslVSRFLLSLGLLLL 125

                         90       100       110
                 ....*....|....*....|....*....|
gi 504233627 144 TLSVAASRVILGLHYPSDVLAGALIGGTMG 173
Cdd:cd03382  126 ALLVSYSRVYLGYHTVSQVVVGAIVGILLG 155
PAP2_haloperoxidase cd03398
PAP2, haloperoxidase_like subfamily. Haloperoxidases catalyze the oxidation of halides such as ...
 147-173 8.51e-03

PAP2, haloperoxidase_like subfamily. Haloperoxidases catalyze the oxidation of halides such as bromide or chloride by hydrogen peroxide, which results in subsequent halogenation of organic substrates, or halide-assisted disproportionation of hydrogen peroxide forming dioxygen. They are likely to participate in the biosynthesis of halogenated natural products, such as volatile halogenated hydrocarbons, chiral halogenated terpenes, acetogenins and indoles.


Pssm-ID: 239492  Cd Length: 232  Bit Score: 35.86  E-value: 8.51e-03
                         10        20
                 ....*....|....*....|....*..
gi 504233627 147 VAASRVILGLHYPSDVLAGALIGGTMG 173
Cdd:cd03398  201 VAISRVYAGVHFRSDDAAGAALGEQIG 227
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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