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Conserved domains on  [gi|504289634|ref|WP_014476736|]
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MULTISPECIES: N-acetyltransferase [Bacillus]

Protein Classification

GNAT family N-acetyltransferase( domain architecture ID 10014340)

GNAT family N-acetyltransferase catalyzes the transfer of an acetyl group from acetyl-CoA to a substrate, similar to Bacillus subtilis putative N-acetyltransferase YlbP

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK13688 PRK13688
N-acetyltransferase;
1-158 5.93e-106

N-acetyltransferase;


:

Pssm-ID: 237470  Cd Length: 156  Bit Score: 299.24  E-value: 5.93e-106
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504289634   1 MTKVERLLINYKTLEEFKKFKEYGIQELSMLEELQDNIIENDSTSPFYGIYFGDKLVARMSLYQVNGKSNPYFDNRQDYL 80
Cdd:PRK13688   1 MPEVKRLLINYKTLEEFKKFREFGNQELSMLEELQANIIENDSESPFYGIYYGDSLVARMSLYKKGGVEEPYFEDTQDYL 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 504289634  81 ELWKLEVLPGYQNRGYGRALVEFAKSFKMPIRTNPRMKSAEFWNKMNFKTVKYDmaRDKGENPLIWHPDMDHEMTPGE 158
Cdd:PRK13688  81 ELWKLEVLPKYQNRGYGEMLVDFAKSFQLPIKTIARNKSKDFWLKLGFTPVEYK--NDEGEDPLVWHPETNLEAVTNE 156
 
Name Accession Description Interval E-value
PRK13688 PRK13688
N-acetyltransferase;
1-158 5.93e-106

N-acetyltransferase;


Pssm-ID: 237470  Cd Length: 156  Bit Score: 299.24  E-value: 5.93e-106
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504289634   1 MTKVERLLINYKTLEEFKKFKEYGIQELSMLEELQDNIIENDSTSPFYGIYFGDKLVARMSLYQVNGKSNPYFDNRQDYL 80
Cdd:PRK13688   1 MPEVKRLLINYKTLEEFKKFREFGNQELSMLEELQANIIENDSESPFYGIYYGDSLVARMSLYKKGGVEEPYFEDTQDYL 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 504289634  81 ELWKLEVLPGYQNRGYGRALVEFAKSFKMPIRTNPRMKSAEFWNKMNFKTVKYDmaRDKGENPLIWHPDMDHEMTPGE 158
Cdd:PRK13688  81 ELWKLEVLPKYQNRGYGEMLVDFAKSFQLPIKTIARNKSKDFWLKLGFTPVEYK--NDEGEDPLVWHPETNLEAVTNE 156
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 14-128 1.96e-06

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 44.43  E-value: 1.96e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504289634   14 LEEFKKFKEYGIQELSMLEELQDNIIENDStspFYGIYFGDKLVARMSLYQvngksnpyFDNRQDYLELWKLEVLPGYQN 93
Cdd:pfam00583   5 YELLSEEFPEPWPDEPLDLLEDWDEDASEG---FFVAEEDGELVGFASLSI--------IDDEPPVGEIEGLAVAPEYRG 73

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 504289634   94 RGYGRALV----EFAKSFKMPI----RTNPRMKSAEFWNKMNF 128
Cdd:pfam00583  74 KGIGTALLqallEWARERGCERifleVAADNLAAIALYEKLGF 116
PhnO COG0454
N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, ...
 25-106 1.07e-05

N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, General function prediction only];


Pssm-ID: 440222 [Multi-domain]  Cd Length: 136  Bit Score: 42.73  E-value: 1.07e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504289634  25 IQELSMLEELQDNI---IENDSTSPFYGIYFGDKLVARMSLYQVNGKSnpyfdnrqdyLELWKLEVLPGYQNRGYGRALV 101
Cdd:COG0454   11 INFILLIEALDAELkamEGSLAGAEFIAVDDKGEPIGFAGLRRLDDKV----------LELKRLYVLPEYRGKGIGKALL 80


                 ....*
gi 504289634 102 EFAKS 106
Cdd:COG0454   81 EALLE 85
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 47-107 1.69e-05

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 40.72  E-value: 1.69e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 504289634  47 FYGIYFGDKLVARMSLYQvngksnpyFDNRQDYLELWKLEVLPGYQNRGYGRALVEFAKSF 107
Cdd:cd04301    1 FLVAEDDGEIVGFASLSP--------DGSGGDTAYIGDLAVLPEYRGKGIGSALLEAAEEE 53
 
Name Accession Description Interval E-value
PRK13688 PRK13688
N-acetyltransferase;
1-158 5.93e-106

N-acetyltransferase;


Pssm-ID: 237470  Cd Length: 156  Bit Score: 299.24  E-value: 5.93e-106
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504289634   1 MTKVERLLINYKTLEEFKKFKEYGIQELSMLEELQDNIIENDSTSPFYGIYFGDKLVARMSLYQVNGKSNPYFDNRQDYL 80
Cdd:PRK13688   1 MPEVKRLLINYKTLEEFKKFREFGNQELSMLEELQANIIENDSESPFYGIYYGDSLVARMSLYKKGGVEEPYFEDTQDYL 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 504289634  81 ELWKLEVLPGYQNRGYGRALVEFAKSFKMPIRTNPRMKSAEFWNKMNFKTVKYDmaRDKGENPLIWHPDMDHEMTPGE 158
Cdd:PRK13688  81 ELWKLEVLPKYQNRGYGEMLVDFAKSFQLPIKTIARNKSKDFWLKLGFTPVEYK--NDEGEDPLVWHPETNLEAVTNE 156
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 14-128 1.96e-06

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 44.43  E-value: 1.96e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504289634   14 LEEFKKFKEYGIQELSMLEELQDNIIENDStspFYGIYFGDKLVARMSLYQvngksnpyFDNRQDYLELWKLEVLPGYQN 93
Cdd:pfam00583   5 YELLSEEFPEPWPDEPLDLLEDWDEDASEG---FFVAEEDGELVGFASLSI--------IDDEPPVGEIEGLAVAPEYRG 73

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 504289634   94 RGYGRALV----EFAKSFKMPI----RTNPRMKSAEFWNKMNF 128
Cdd:pfam00583  74 KGIGTALLqallEWARERGCERifleVAADNLAAIALYEKLGF 116
PhnO COG0454
N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, ...
 25-106 1.07e-05

N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, General function prediction only];


Pssm-ID: 440222 [Multi-domain]  Cd Length: 136  Bit Score: 42.73  E-value: 1.07e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504289634  25 IQELSMLEELQDNI---IENDSTSPFYGIYFGDKLVARMSLYQVNGKSnpyfdnrqdyLELWKLEVLPGYQNRGYGRALV 101
Cdd:COG0454   11 INFILLIEALDAELkamEGSLAGAEFIAVDDKGEPIGFAGLRRLDDKV----------LELKRLYVLPEYRGKGIGKALL 80


                 ....*
gi 504289634 102 EFAKS 106
Cdd:COG0454   81 EALLE 85
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 47-107 1.69e-05

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 40.72  E-value: 1.69e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 504289634  47 FYGIYFGDKLVARMSLYQvngksnpyFDNRQDYLELWKLEVLPGYQNRGYGRALVEFAKSF 107
Cdd:cd04301    1 FLVAEDDGEIVGFASLSP--------DGSGGDTAYIGDLAVLPEYRGKGIGSALLEAAEEE 53
RimI COG0456
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
 72-104 5.84e-05

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 39.64  E-value: 5.84e-05
                         10        20        30
                 ....*....|....*....|....*....|...
gi 504289634  72 YFDNRQDYLELWKLEVLPGYQNRGYGRALVEFA 104
Cdd:COG0456    6 GLVDGGDEAEIEDLAVDPEYRGRGIGRALLEAA 38
Acetyltransf_7 pfam13508
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
 47-129 1.15e-04

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


Pssm-ID: 463905 [Multi-domain]  Cd Length: 84  Bit Score: 38.97  E-value: 1.15e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504289634   47 FYGIYFGDKLVARMSLYQVNGKSNPYfdnrqdYLELWkleVLPGYQNRGYGRALVEFAKSFK-----MPIRTNPRMKSAE 121
Cdd:pfam13508   5 FFVAEDDGKIVGFAALLPLDDEGALA------ELRLA---VHPEYRGQGIGRALLEAAEAAAkeggiKLLELETTNRAAA 75


                  ....*...
gi 504289634  122 FWNKMNFK 129
Cdd:pfam13508  76 FYEKLGFE 83
ArgA COG1246
N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and ...
 24-104 1.52e-04

N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and metabolism]; N-acetylglutamate synthase or related acetyltransferase, GNAT family is part of the Pathway/BioSystem: Arginine biosynthesis


Pssm-ID: 440859 [Multi-domain]  Cd Length: 132  Bit Score: 39.59  E-value: 1.52e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504289634  24 GIQELSMLEELQDNIIEndstspFYGIYFGDKLVARMSLYQVNGksnpyfdnrqDYLELWKLEVLPGYQNRGYGRALVEF 103
Cdd:COG1246   13 AILELIRPYALEEEIGE------FWVAEEDGEIVGCAALHPLDE----------DLAELRSLAVHPDYRGRGIGRRLLEA 76


                 .
gi 504289634 104 A 104
Cdd:COG1246   77 L 77
yhbS COG3153
Predicted N-acetyltransferase YhbS [General function prediction only];
73-104 3.52e-04

Predicted N-acetyltransferase YhbS [General function prediction only];


Pssm-ID: 442387 [Multi-domain]  Cd Length: 142  Bit Score: 38.53  E-value: 3.52e-04
                         10        20        30
                 ....*....|....*....|....*....|..
gi 504289634  73 FDNRQDYLELWKLEVLPGYQNRGYGRALVEFA 104
Cdd:COG3153   61 IDGEGPALLLGPLAVDPEYRGQGIGRALMRAA 92
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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