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Conserved domains on  [gi|504426538|ref|WP_014613640|]
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1-acyl-sn-glycerol-3-phosphate acyltransferase [Staphylococcus pseudintermedius]

Protein Classification

lysophospholipid acyltransferase family protein( domain architecture ID 11415180)

lysophospholipid acyltransferase (LPLAT) family protein may act as an acyltransferase of a de novo or remodeling pathway of glycerophospholipid biosynthesis, catalyzing the incorporation of an acyl group from either acyl-CoAs or acyl-acyl carrier proteins (acyl-ACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid; 1-acyl-sn-glycerol-3-phosphate acyltransferase, for example, converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the 2 position by utilizing either acyl-CoA or acyl-ACP as the fatty acyl donor;

CATH:  1.10.1200.50
EC:  2.3.1.-
Gene Ontology:  GO:0008654|GO:0016746
PubMed:  18718904|18931347
SCOP:  4003349

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PlsC COG0204
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ...
 1-197 1.43e-47

1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


:

Pssm-ID: 439974 [Multi-domain]  Cd Length: 215  Bit Score: 155.17  E-value: 1.43e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504426538   1 MLYHIIGKIIELIVVKVLKNLEVIGREHQPKTNRYVVTCNHESYNEIILLGvSLLPNQIHYMAKQELFKNKYFGGLLTRL 80
Cdd:COG0204   11 FRYRLVRLWARLLLRLLGVRVRVEGLENLPADGPVLIVANHQSWLDILLLL-AALPRPVRFVAKKELFKIPLLGWLLRAL 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504426538  81 NAFPVNRENPGPS--TLKTPVKLLRDNKIVGIFPQGHRTTGET--PLKRGAATIAILAKQPILPAAYVG----PTKLLGL 152
Cdd:COG0204   90 GAIPVDRSKRRAAlrALRQAVEALKAGESLVIFPEGTRSPDGRllPFKTGAARLALEAGVPIVPVAIDGteraLPKGFLP 169

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 504426538 153 FTGKAYIKFGEPIDTTDLPKDlNRQEKVDYVTQQISARTKQLQDE 197
Cdd:COG0204  170 RPGKVTVRIGPPIDPSDLEGE-DRRELAERLRAAIEALLAELRAE 213
 
Name Accession Description Interval E-value
PlsC COG0204
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ...
 1-197 1.43e-47

1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 439974 [Multi-domain]  Cd Length: 215  Bit Score: 155.17  E-value: 1.43e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504426538   1 MLYHIIGKIIELIVVKVLKNLEVIGREHQPKTNRYVVTCNHESYNEIILLGvSLLPNQIHYMAKQELFKNKYFGGLLTRL 80
Cdd:COG0204   11 FRYRLVRLWARLLLRLLGVRVRVEGLENLPADGPVLIVANHQSWLDILLLL-AALPRPVRFVAKKELFKIPLLGWLLRAL 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504426538  81 NAFPVNRENPGPS--TLKTPVKLLRDNKIVGIFPQGHRTTGET--PLKRGAATIAILAKQPILPAAYVG----PTKLLGL 152
Cdd:COG0204   90 GAIPVDRSKRRAAlrALRQAVEALKAGESLVIFPEGTRSPDGRllPFKTGAARLALEAGVPIVPVAIDGteraLPKGFLP 169

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 504426538 153 FTGKAYIKFGEPIDTTDLPKDlNRQEKVDYVTQQISARTKQLQDE 197
Cdd:COG0204  170 RPGKVTVRIGPPIDPSDLEGE-DRRELAERLRAAIEALLAELRAE 213
LPLAT_AGPAT-like cd07989
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; ...
 20-187 4.20e-41

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), Tafazzin (product of Barth syndrome gene), and similar proteins.


Pssm-ID: 153251 [Multi-domain]  Cd Length: 184  Bit Score: 137.40  E-value: 4.20e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504426538  20 NLEVIGREHQPKTNRYVVTCNHESYNEIILLGvSLLPNQIHYMAKQELFKNKYFGGLLTRLNAFPVNRENP--GPSTLKT 97
Cdd:cd07989   11 RVRVEGLENLPPKGPVIIVANHQSYLDPLVLG-AALPRPIRFVAKKELFKIPFLGWLLRLLGAIPIDRGNGrsAREALRE 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504426538  98 PVKLLRDNKIVGIFPQGHRTTGET--PLKRGAATIAILAKQPILPAAYVG-----PTKLLGLFTGKAYIKFGEPIDTTDL 170
Cdd:cd07989   90 AIEALKEGESVVIFPEGTRSRDGEllPFKSGAFRLAKEAGVPIVPVAISGtwgslPKGKKLPRPGRVTVRIGEPIPPEGL 169

                        170
                 ....*....|....*..
gi 504426538 171 PKdlnRQEKVDYVTQQI 187
Cdd:cd07989  170 EL---AEEDRKELREKV 183
AGP_acyltrn TIGR00530
1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous ...
 20-144 4.46e-34

1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous region of a collection of related proteins, several of which are known to act as 1-acyl-sn-glycerol-3-phosphate acyltransferases (EC 2.3.1.51). Proteins scoring above the trusted cutoff are likely to have the same general activity. However, there is variation among characterized members as to whether the acyl group can be donated by acyl carrier protein or coenzyme A, and in the length and saturation of the donated acyl group. 1-acyl-sn-glycerol-3-phosphate acyltransferase is also called 1-AGP acyltransferase, lysophosphatidic acid acyltransferase, and LPA acyltransferase. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 129621 [Multi-domain]  Cd Length: 130  Bit Score: 117.83  E-value: 4.46e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504426538   20 NLEVIGREHQPKTNRYVVTCNHESYNEIILLGVsLLPNQIHYMAKQELFKNKYFGGLLTRLNAFPVNREN--PGPSTLKT 97
Cdd:TIGR00530   3 KVEVVGPENLPAKSPVLVVANHQSNLDPLTLSA-AFPPPIVFIAKKELKWIPFFGIMLWLTGAIFIDRENirAIATALKA 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 504426538   98 PVKLLRDNKIVGIFPQGHRTTGETPL--KRGAATIAILAKQPILPAAYV 144
Cdd:TIGR00530  82 AIEVLKQGRSIGVFPEGTRSRGRDILpfKKGAFHIAIKAGVPILPVVLS 130
PlsC smart00563
Phosphate acyltransferases; Function in phospholipid biosynthesis and have either ...
 35-145 4.90e-25

Phosphate acyltransferases; Function in phospholipid biosynthesis and have either glycerolphosphate, 1-acylglycerolphosphate, or 2-acylglycerolphosphoethanolamine acyltransferase activities. Tafazzin, the product of the gene mutated in patients with Barth syndrome, is a member of this family.


Pssm-ID: 214724 [Multi-domain]  Cd Length: 118  Bit Score: 94.34  E-value: 4.90e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504426538    35 YVVTCNHESYNEIILLGvSLLPNQ---IHYMAKQELFKNKYFGGLLTRLNAFPVNRENPGP--STLKTPVKLLRDNKIVG 109
Cdd:smart00563   1 ALVVANHQSFLDPLVLS-ALLPRKlgrVRFVAKKELFYVPLLGWLLRLLGAIFIDRSNGRKarAALREAVELLKEGEWLL 79

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 504426538   110 IFPQGHRTTGET--PLKRGAATIAILAKQPILPAAYVG 145
Cdd:smart00563  80 IFPEGTRSRPGKllPFKKGAARLALEAGVPIVPVAIRG 117
Acyltransferase pfam01553
Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis ...
 20-144 2.40e-24

Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function. This family also includes tafazzin, the Barth syndrome gene.


Pssm-ID: 366704 [Multi-domain]  Cd Length: 131  Bit Score: 92.73  E-value: 2.40e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504426538   20 NLEVIGREHQPKTNRYVVTCNHESYNEIILLGvSLLPNQ---IHYMAKQELFKNKYFGGLLTRLNAFPVNRENPG--PST 94
Cdd:pfam01553   1 RIEVHGLENLPRGGPAIVVANHQSYLDVLLLS-LALYKRgrpLVFVAKKELFDIPLVGWLMRLLGCIFIDRKNRKdaAGT 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 504426538   95 LKTPVKLLRDNKIVGIFPQGHRT-TGET-PLKRGAATIAILAKQPILPAAYV 144
Cdd:pfam01553  80 LEYLVELLREGKLVVIFPEGTRSrEGELlPFKKGAFRLAIEAGVPIVPVAIS 131
PLN02901 PLN02901
1-acyl-sn-glycerol-3-phosphate acyltransferase
 4-180 6.97e-08

1-acyl-sn-glycerol-3-phosphate acyltransferase


Pssm-ID: 215488 [Multi-domain]  Cd Length: 214  Bit Score: 50.88  E-value: 6.97e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504426538   4 HIIGKIIELIVVKVLKNLEVIGREHQPKTNRYVV-TCNHESYNEIILLgvSLLPNQIHYMAKQELFKNKYFGGLLTRLNA 82
Cdd:PLN02901  20 HFINKVWATLSTSPFYKIEVEGLENLPSPDEPAVyVSNHQSFLDIYTL--FHLGRPFKFISKTSIFLIPIIGWAMYMTGH 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504426538  83 FPVNRENPGPS--TLKTPVKLLRDNKIVGIFPQGHRTTGET--PLKRGAATIAILAKQPILPAAYVGPTKLLG------L 152
Cdd:PLN02901  98 IPLKRMDRRSQleCLKRCMELLKKGASVFFFPEGTRSKDGKlaAFKKGAFSVAAKTGVPVVPITLVGTGKIMPngkegiL 177

                        170       180
                 ....*....|....*....|....*...
gi 504426538 153 FTGKAYIKFGEPIDTTDLPKDLNRQEKV 180
Cdd:PLN02901 178 NPGSVKVVIHPPIEGSDADELCNEARKV 205
 
Name Accession Description Interval E-value
PlsC COG0204
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ...
 1-197 1.43e-47

1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 439974 [Multi-domain]  Cd Length: 215  Bit Score: 155.17  E-value: 1.43e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504426538   1 MLYHIIGKIIELIVVKVLKNLEVIGREHQPKTNRYVVTCNHESYNEIILLGvSLLPNQIHYMAKQELFKNKYFGGLLTRL 80
Cdd:COG0204   11 FRYRLVRLWARLLLRLLGVRVRVEGLENLPADGPVLIVANHQSWLDILLLL-AALPRPVRFVAKKELFKIPLLGWLLRAL 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504426538  81 NAFPVNRENPGPS--TLKTPVKLLRDNKIVGIFPQGHRTTGET--PLKRGAATIAILAKQPILPAAYVG----PTKLLGL 152
Cdd:COG0204   90 GAIPVDRSKRRAAlrALRQAVEALKAGESLVIFPEGTRSPDGRllPFKTGAARLALEAGVPIVPVAIDGteraLPKGFLP 169

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 504426538 153 FTGKAYIKFGEPIDTTDLPKDlNRQEKVDYVTQQISARTKQLQDE 197
Cdd:COG0204  170 RPGKVTVRIGPPIDPSDLEGE-DRRELAERLRAAIEALLAELRAE 213
LPLAT_AGPAT-like cd07989
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; ...
 20-187 4.20e-41

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), Tafazzin (product of Barth syndrome gene), and similar proteins.


Pssm-ID: 153251 [Multi-domain]  Cd Length: 184  Bit Score: 137.40  E-value: 4.20e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504426538  20 NLEVIGREHQPKTNRYVVTCNHESYNEIILLGvSLLPNQIHYMAKQELFKNKYFGGLLTRLNAFPVNRENP--GPSTLKT 97
Cdd:cd07989   11 RVRVEGLENLPPKGPVIIVANHQSYLDPLVLG-AALPRPIRFVAKKELFKIPFLGWLLRLLGAIPIDRGNGrsAREALRE 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504426538  98 PVKLLRDNKIVGIFPQGHRTTGET--PLKRGAATIAILAKQPILPAAYVG-----PTKLLGLFTGKAYIKFGEPIDTTDL 170
Cdd:cd07989   90 AIEALKEGESVVIFPEGTRSRDGEllPFKSGAFRLAKEAGVPIVPVAISGtwgslPKGKKLPRPGRVTVRIGEPIPPEGL 169

                        170
                 ....*....|....*..
gi 504426538 171 PKdlnRQEKVDYVTQQI 187
Cdd:cd07989  170 EL---AEEDRKELREKV 183
AGP_acyltrn TIGR00530
1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous ...
 20-144 4.46e-34

1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous region of a collection of related proteins, several of which are known to act as 1-acyl-sn-glycerol-3-phosphate acyltransferases (EC 2.3.1.51). Proteins scoring above the trusted cutoff are likely to have the same general activity. However, there is variation among characterized members as to whether the acyl group can be donated by acyl carrier protein or coenzyme A, and in the length and saturation of the donated acyl group. 1-acyl-sn-glycerol-3-phosphate acyltransferase is also called 1-AGP acyltransferase, lysophosphatidic acid acyltransferase, and LPA acyltransferase. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 129621 [Multi-domain]  Cd Length: 130  Bit Score: 117.83  E-value: 4.46e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504426538   20 NLEVIGREHQPKTNRYVVTCNHESYNEIILLGVsLLPNQIHYMAKQELFKNKYFGGLLTRLNAFPVNREN--PGPSTLKT 97
Cdd:TIGR00530   3 KVEVVGPENLPAKSPVLVVANHQSNLDPLTLSA-AFPPPIVFIAKKELKWIPFFGIMLWLTGAIFIDRENirAIATALKA 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 504426538   98 PVKLLRDNKIVGIFPQGHRTTGETPL--KRGAATIAILAKQPILPAAYV 144
Cdd:TIGR00530  82 AIEVLKQGRSIGVFPEGTRSRGRDILpfKKGAFHIAIKAGVPILPVVLS 130
PlsC smart00563
Phosphate acyltransferases; Function in phospholipid biosynthesis and have either ...
 35-145 4.90e-25

Phosphate acyltransferases; Function in phospholipid biosynthesis and have either glycerolphosphate, 1-acylglycerolphosphate, or 2-acylglycerolphosphoethanolamine acyltransferase activities. Tafazzin, the product of the gene mutated in patients with Barth syndrome, is a member of this family.


Pssm-ID: 214724 [Multi-domain]  Cd Length: 118  Bit Score: 94.34  E-value: 4.90e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504426538    35 YVVTCNHESYNEIILLGvSLLPNQ---IHYMAKQELFKNKYFGGLLTRLNAFPVNRENPGP--STLKTPVKLLRDNKIVG 109
Cdd:smart00563   1 ALVVANHQSFLDPLVLS-ALLPRKlgrVRFVAKKELFYVPLLGWLLRLLGAIFIDRSNGRKarAALREAVELLKEGEWLL 79

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 504426538   110 IFPQGHRTTGET--PLKRGAATIAILAKQPILPAAYVG 145
Cdd:smart00563  80 IFPEGTRSRPGKllPFKKGAARLALEAGVPIVPVAIRG 117
Acyltransferase pfam01553
Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis ...
 20-144 2.40e-24

Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function. This family also includes tafazzin, the Barth syndrome gene.


Pssm-ID: 366704 [Multi-domain]  Cd Length: 131  Bit Score: 92.73  E-value: 2.40e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504426538   20 NLEVIGREHQPKTNRYVVTCNHESYNEIILLGvSLLPNQ---IHYMAKQELFKNKYFGGLLTRLNAFPVNRENPG--PST 94
Cdd:pfam01553   1 RIEVHGLENLPRGGPAIVVANHQSYLDVLLLS-LALYKRgrpLVFVAKKELFDIPLVGWLMRLLGCIFIDRKNRKdaAGT 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 504426538   95 LKTPVKLLRDNKIVGIFPQGHRT-TGET-PLKRGAATIAILAKQPILPAAYV 144
Cdd:pfam01553  80 LEYLVELLREGKLVVIFPEGTRSrEGELlPFKKGAFRLAIEAGVPIVPVAIS 131
LPLAT cd06551
Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; ...
 12-187 2.07e-18

Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Lysophospholipid acyltransferase (LPLAT) superfamily members are acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis. These proteins catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this superfamily are LPLATs such as glycerol-3-phosphate 1-acyltransferase (GPAT, PlsB), 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), lysophosphatidylcholine acyltransferase 1 (LPCAT-1), lysophosphatidylethanolamine acyltransferase (LPEAT, also known as, MBOAT2, membrane-bound O-acyltransferase domain-containing protein 2), lipid A biosynthesis lauroyl/myristoyl acyltransferase, 2-acylglycerol O-acyltransferase (MGAT), dihydroxyacetone phosphate acyltransferase (DHAPAT, also known as 1 glycerol-3-phosphate O-acyltransferase 1) and Tafazzin (the protein product of the Barth syndrome (TAZ) gene).


Pssm-ID: 153244 [Multi-domain]  Cd Length: 187  Bit Score: 79.00  E-value: 2.07e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504426538  12 LIVVKVLKNLEVIGREHQPKTNRYVVTCNHESYNEIILLGVSL---LPNQIHYMAKQELFKNKYFgglLTRLNAFPVNRE 88
Cdd:cd06551    5 LLNFFGFVRLEVKGPPPPPGGGPVLFVSNHSSWWDGLILFLLLergLRRDVYGLMDEELLERYPF---FTRLGAFSVDRD 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504426538  89 NPGP--STLKTPVKLLRDNKI-VGIFPQGHRTTGETPL---KRGAATIAILAKQPILPAA--YvgpTKLLGLFTGKAYIK 160
Cdd:cd06551   82 SPRSaaKSLKYVARLLSKPGSvVWIFPEGTRTRRDKRPlqfKPGVAHLAEKAGVPIVPVAlrY---TFELFEQFPEIFVR 158

                        170       180
                 ....*....|....*....|....*...
gi 504426538 161 FGEPID-TTDLPKDLNRQEKVDYVTQQI 187
Cdd:cd06551  159 IGPPIPyAETALGEELAAELANRLTRLL 186
LPLAT_AAK14816-like cd07992
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ...
 19-190 1.35e-17

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown AAK14816-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are uncharacterized glycerol-3-phosphate acyltransferases such as the Plasmodium falciparum locus AAK14816 putative acyltransferase, and similar proteins.


Pssm-ID: 153254 [Multi-domain]  Cd Length: 203  Bit Score: 77.30  E-value: 1.35e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504426538  19 KNLEVIGREHQPKTNRYVVTCNHEsyNEII--LLGVSLLPNQIHYMAKQELFKNKYFGGLLTRLNAFPVNRENPGPSTLK 96
Cdd:cd07992   14 RRITVVGRENVPKDGPVIFLGNHP--NALIdpLLLAATLRRPVRFLAKADLFKNPLIGWLLESFGAIPVYRPKDLARGGI 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504426538  97 TPVK----------LLRDNKIVGIFPQGHRTTGET--PLKRGAATIAI--LAKQ----PILPAA--YVGPTKllglFTGK 156
Cdd:cd07992   92 GKISnaavfdavgeALKAGGAIGIFPEGGSHDRPRllPLKAGAARMALeaLEAGqkdvKIVPVGlnYEDKSR----FRSR 167

                        170       180       190
                 ....*....|....*....|....*....|....
gi 504426538 157 AYIKFGEPIDTTDLPKDLNRQEKVDYVTQQISAR 190
Cdd:cd07992  168 VLVEFGKPISVSAFEEAEASRDVEKKLINQLEAE 201
LPLAT_ABO13168-like cd07988
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ...
 47-176 6.09e-12

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are uncharacterized phospholipid/glycerol acyltransferases such as the Acinetobacter baumannii ATCC 17978 locus ABO13168 putative acyltransferase, and similar proteins.


Pssm-ID: 153250 [Multi-domain]  Cd Length: 163  Bit Score: 61.08  E-value: 6.09e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504426538  47 IILLGVSLLPNQIHYMAKQELFKNKyFGGLLTRLNAFPVNRENPGpSTLKTPVKLLRDNK--IVGIFPQGHRTTGEtPLK 124
Cdd:cd07988   37 LGLLAAFALGLKISFLGKHSLFKPP-LGPFMRWLGGIPVDRSRAG-GLVEQVVEEFRRREefVLAIAPEGTRSKVD-KWK 113

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 504426538 125 RGAATIAILAKQPILPAAYVGPTKLLGlftgkayikFGEPID-TTDLPKDLNR 176
Cdd:cd07988  114 TGFYHIARGAGVPILLVYLDYKRKTVG---------IGPLFEpSGDIEADLAA 157
PLN02901 PLN02901
1-acyl-sn-glycerol-3-phosphate acyltransferase
 4-180 6.97e-08

1-acyl-sn-glycerol-3-phosphate acyltransferase


Pssm-ID: 215488 [Multi-domain]  Cd Length: 214  Bit Score: 50.88  E-value: 6.97e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504426538   4 HIIGKIIELIVVKVLKNLEVIGREHQPKTNRYVV-TCNHESYNEIILLgvSLLPNQIHYMAKQELFKNKYFGGLLTRLNA 82
Cdd:PLN02901  20 HFINKVWATLSTSPFYKIEVEGLENLPSPDEPAVyVSNHQSFLDIYTL--FHLGRPFKFISKTSIFLIPIIGWAMYMTGH 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504426538  83 FPVNRENPGPS--TLKTPVKLLRDNKIVGIFPQGHRTTGET--PLKRGAATIAILAKQPILPAAYVGPTKLLG------L 152
Cdd:PLN02901  98 IPLKRMDRRSQleCLKRCMELLKKGASVFFFPEGTRSKDGKlaAFKKGAFSVAAKTGVPVVPITLVGTGKIMPngkegiL 177

                        170       180
                 ....*....|....*....|....*...
gi 504426538 153 FTGKAYIKFGEPIDTTDLPKDLNRQEKV 180
Cdd:PLN02901 178 NPGSVKVVIHPPIEGSDADELCNEARKV 205
LPLAT_MGAT-like cd07987
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; ...
 22-197 1.53e-07

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this suubgroup are such LPLATs as 2-acylglycerol O-acyltransferase (MGAT), and similar proteins.


Pssm-ID: 153249 [Multi-domain]  Cd Length: 212  Bit Score: 49.59  E-value: 1.53e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504426538  22 EVIGREHQPKTNRYVVTCNHESY-NEIILLGVSLL----PNQIHYMAKQELFKNKYFGGLLTRLNAFPVNRENPgpstlk 96
Cdd:cd07987    9 EVRGLENIPDEGPALLVHPHGGLpIDGALLAAAFLllfpGRLPRALADHFLFPLPGLRDLLRRLGAVPGSRENC------ 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504426538  97 tpVKLLRDNKIVGIFPQG-----HRTTGETPL----KRGAATIAILAKQPILPAAYVGPT------------------KL 149
Cdd:cd07987   83 --VRLLREGELVLIFPGGarealKSKREEYYLlwkkRKGFARLALRAGAPIVPVFTFGEEelfrvlgdpdgpvgkrlfRL 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 504426538 150 LGL-FTGKAYIKFGEPIDTTDLPKDLNRQEKVDYVTQQISARTKQLQDE 197
Cdd:cd07987  161 LPLpRRLPLYPVFGEPIVVPRPPIPDPPDEDVEELHQKYIAALRELIEK 209
PRK06814 PRK06814
acyl-[ACP]--phospholipid O-acyltransferase;
13-140 6.54e-06

acyl-[ACP]--phospholipid O-acyltransferase;


Pssm-ID: 235865 [Multi-domain]  Cd Length: 1140  Bit Score: 46.11  E-value: 6.54e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504426538   13 IVVKVLKNLEVIGREHQPKT-NRYVVTCNHESYNEIILLgVSLLPNQI-----HYMAKQelFKNKYFgglLTRLNAFPVN 86
Cdd:PRK06814  433 ILFRAFYRVEVKGLENLQKAgKKAVIAANHVSFLDGPLL-AAYLPEEPtfaidTDIAKA--WWVKPF---LKLAKALPVD 506

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 504426538   87 RENPgpSTLKTPVKLLRDNKIVGIFPQGHRTTGETPLK--RGAATIAILAKQPILP 140
Cdd:PRK06814  507 PTNP--MATRTLIKEVQKGEKLVIFPEGRITVTGSLMKiyDGPGMIADKAGAMVVP 560
PRK08633 PRK08633
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
 9-140 5.44e-05

2-acyl-glycerophospho-ethanolamine acyltransferase; Validated


Pssm-ID: 236315 [Multi-domain]  Cd Length: 1146  Bit Score: 43.37  E-value: 5.44e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504426538    9 IIELIVVKVLKNLEVIGREHQPKTNRYVVTCNHESYNEIILLGVSLlPNQIHYMAKQELFKNKYFGGLLTRLNAFPVNRE 88
Cdd:PRK08633  417 FLLLLLMHTRYRLRVEGRENIPAKGGALLLGNHVSWIDWALLQAAS-PRPIRFVMERSIYEKWYLKWFFKLFGVIPISSG 495

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 504426538   89 NPgPSTLKTPVKLLRDNKIVGIFPQGHRT-TGE-TPLKRGAATIAILAKQPILP 140
Cdd:PRK08633  496 GS-KESLEFIRKALDDGEVVCIFPEGAITrNGQlNEFKRGFELIVKGTDVPIIP 548
LPLAT_LABLAT-like cd07984
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; ...
 46-169 3.83e-04

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as lipid A biosynthesis lauroyl/myristoyl (LABLAT, HtrB) acyltransferases and similar proteins.


Pssm-ID: 153246 [Multi-domain]  Cd Length: 192  Bit Score: 39.89  E-value: 3.83e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504426538  46 EIILLGVSLLPNQIHYMAKQelFKNKYFGGLLTRL----NAFPVNRENpgpsTLKTPVKLLRDNKIVGIFP-QGHRTTGE 120
Cdd:cd07984   33 ELAGLALALLGYPVTVVYRP--LKNPLLDRLITRGrerfGARLIPRGG----GLRELIRALKKGEIVGILPdQDPGRKGG 106

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 504426538 121 TPLK---------RGAATIAILAKQPILPAAYVgptkllglFTGKAY--IKFGEPIDTTD 169
Cdd:cd07984  107 VFVPffgrpaatpTGPARLALKTGAPVVPAFAY--------RLPGGGyrIEFEPPLENPP 158
LPLAT_DUF374-like cd07983
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; ...
 95-199 1.24e-03

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are the uncharacterized DUF374 phospholipid/glycerol acyltransferases and similar proteins.


Pssm-ID: 153245 [Multi-domain]  Cd Length: 189  Bit Score: 38.35  E-value: 1.24e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504426538  95 LKTPVKLLRDNKIVGIFPQGHRttGetP---LKRGAATIAILAKQPILPAAYvGPTK-----------LLGLFtGKAYIK 160
Cdd:cd07983   87 LREMLRALKDGYNIAITPDGPR--G--PrykVKPGVILLARKSGAPIVPVAI-AASRawrlkswdrfiIPKPF-SRVVIV 160

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 504426538 161 FGEPIdttDLPKDLNRQEKVDYvtqqisarTKQLQDELN 199
Cdd:cd07983  161 FGEPI---HVPPDADEEELEEY--------RLELEAALN 188
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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