YmdB family metallophosphoesterase similar to Bacillus subtilis YmdB, a phosphodiesterase with activity against 2',3'- and 3',5'-cyclic nucleotide monophosphates, that functions as a global regulator of late adaptive responses
Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; DR1281 is an ...
2-256
8.33e-137
Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; DR1281 is an uncharacterized Deinococcus radiodurans protein with a domain that belongs to the metallophosphatase (MPP) superfamily. MPPs are functionally diverse, but all share a conserved domain with an active site consisting of two metal ions (usually manganese, iron, or zinc) coordinated with octahedral geometry by a cage of histidine, aspartate, and asparagine residues. The MPP superfamily includes: Mre11/SbcD-like exonucleases, Dbr1-like RNA lariat debranching enzymes, YfcE-like phosphodiesterases, purple acid phosphatases (PAPs), YbbF-like UDP-2,3-diacylglucosamine hydrolases, and acid sphingomyelinases (ASMases). The conserved domain is a double beta-sheet sandwich with a di-metal active site made up of residues located at the C-terminal side of the sheets. This domain is thought to allow for productive metal coordination.
Pssm-ID: 277328 Cd Length: 255 Bit Score: 385.40 E-value: 8.33e-137
metallophosphoesterase, MG_246/BB_0505 family; A member of this family from Mycoplasma ...
1-262
6.60e-123
metallophosphoesterase, MG_246/BB_0505 family; A member of this family from Mycoplasma Pneumoniae has been crystallized and described as a novel phosphatase. [Unknown function, Enzymes of unknown specificity]
Pssm-ID: 161802 Cd Length: 266 Bit Score: 350.67 E-value: 6.60e-123
Bacterial capsule synthesis protein PGA_cap; This protein is a putative poly-gamma-glutamate ...
2-178
4.68e-05
Bacterial capsule synthesis protein PGA_cap; This protein is a putative poly-gamma-glutamate capsule biosynthesis protein found in bacteria. Poly-gamma-glutamate is a natural polymer that may be involved in virulence and may help bacteria survive in high salt concentrations. It is a surface-associated protein.
Pssm-ID: 214858 [Multi-domain] Cd Length: 239 Bit Score: 43.35 E-value: 4.68e-05
Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; DR1281 is an ...
2-256
8.33e-137
Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; DR1281 is an uncharacterized Deinococcus radiodurans protein with a domain that belongs to the metallophosphatase (MPP) superfamily. MPPs are functionally diverse, but all share a conserved domain with an active site consisting of two metal ions (usually manganese, iron, or zinc) coordinated with octahedral geometry by a cage of histidine, aspartate, and asparagine residues. The MPP superfamily includes: Mre11/SbcD-like exonucleases, Dbr1-like RNA lariat debranching enzymes, YfcE-like phosphodiesterases, purple acid phosphatases (PAPs), YbbF-like UDP-2,3-diacylglucosamine hydrolases, and acid sphingomyelinases (ASMases). The conserved domain is a double beta-sheet sandwich with a di-metal active site made up of residues located at the C-terminal side of the sheets. This domain is thought to allow for productive metal coordination.
Pssm-ID: 277328 Cd Length: 255 Bit Score: 385.40 E-value: 8.33e-137
metallophosphoesterase, MG_246/BB_0505 family; A member of this family from Mycoplasma ...
1-262
6.60e-123
metallophosphoesterase, MG_246/BB_0505 family; A member of this family from Mycoplasma Pneumoniae has been crystallized and described as a novel phosphatase. [Unknown function, Enzymes of unknown specificity]
Pssm-ID: 161802 Cd Length: 266 Bit Score: 350.67 E-value: 6.60e-123
Calcineurin-like phosphoesterase; This family includes a diverse range of phosphoesterases, ...
1-94
1.05e-06
Calcineurin-like phosphoesterase; This family includes a diverse range of phosphoesterases, including protein phosphoserine phosphatases, nucleotidases, sphingomyelin phosphodiesterases and 2'-3' cAMP phosphodiesterases as well as nucleases such as bacterial SbcD or yeast MRE11. The most conserved regions in this superfamily centre around the metal chelating residues.
Pssm-ID: 459691 [Multi-domain] Cd Length: 114 Bit Score: 46.44 E-value: 1.05e-06
Bacterial capsule synthesis protein PGA_cap; This protein is a putative poly-gamma-glutamate ...
2-178
4.68e-05
Bacterial capsule synthesis protein PGA_cap; This protein is a putative poly-gamma-glutamate capsule biosynthesis protein found in bacteria. Poly-gamma-glutamate is a natural polymer that may be involved in virulence and may help bacteria survive in high salt concentrations. It is a surface-associated protein.
Pssm-ID: 214858 [Multi-domain] Cd Length: 239 Bit Score: 43.35 E-value: 4.68e-05
Bacterial capsule synthesis protein PGA_cap; This protein is a putative poly-gamma-glutamate ...
2-178
7.13e-04
Bacterial capsule synthesis protein PGA_cap; This protein is a putative poly-gamma-glutamate capsule biosynthesis protein found in bacteria. Poly-gamma-glutamate is a natural polymer that may be involved in virulence and may help bacteria survive in high salt concentrations. It is a surface-associated protein.
Pssm-ID: 430701 [Multi-domain] Cd Length: 246 Bit Score: 39.90 E-value: 7.13e-04
Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
References:
Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
of the residues that compose this conserved feature have been mapped to the query sequence.
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of your query sequence and the protein sequences used to curate the domain model,
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The thumbnail image, if present, provides an approximate view of the feature's location in 3 dimensions.
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Functional characterization of the conserved domain architecture found on the query.
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This image shows a graphical summary of conserved domains identified on the query sequence.
The Show Concise/Full Display button at the top of the page can be used to select the desired level of detail: only top scoring hits
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Domains are color coded according to superfamilies
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if a domain or superfamily has been annotated with functional sites (conserved features),
they are mapped to the query sequence and indicated through sets of triangles
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click on the bars or triangles to view your query sequence embedded in a multiple sequence alignment of the proteins used to develop the corresponding domain model.
The table lists conserved domains identified on the query sequence. Click on the plus sign (+) on the left to display full descriptions, alignments, and scores.
Click on the domain model's accession number to view the multiple sequence alignment of the proteins used to develop the corresponding domain model.
To view your query sequence embedded in that multiple sequence alignment, click on the colored bars in the Graphical Summary portion of the search results page,
or click on the triangles, if present, that represent functional sites (conserved features)
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Concise Display shows only the best scoring domain model, in each hit category listed below except non-specific hits, for each region on the query sequence.
(labeled illustration) Standard Display shows only the best scoring domain model from each source, in each hit category listed below for each region on the query sequence.
(labeled illustration) Full Display shows all domain models, in each hit category below, that meet or exceed the RPS-BLAST threshold for statistical significance.
(labeled illustration) Four types of hits can be shown, as available,
for each region on the query sequence:
specific hits meet or exceed a domain-specific e-value threshold
(illustrated example)
and represent a very high confidence that the query sequence belongs to the same protein family as the sequences use to create the domain model
non-specific hits
meet or exceed the RPS-BLAST threshold for statistical significance (default E-value cutoff of 0.01, or an E-value selected by user via the
advanced search options)
the domain superfamily to which the specific and non-specific hits belong
multi-domain models that were computationally detected and are likely to contain multiple single domains
Retrieve proteins that contain one or more of the domains present in the query sequence, using the Conserved Domain Architecture Retrieval Tool
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