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Conserved domains on  [gi|504427708|ref|WP_014614810|]
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4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase [Staphylococcus pseudintermedius]

Protein Classification

4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase( domain architecture ID 11449259)

4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol in isoprenoid biosynthesis

CATH:  3.30.230.10
EC:  2.7.1.148
Gene Ontology:  GO:0050515|GO:0005524|GO:0016310|GO:0016114
PubMed:  12878729
SCOP:  4000959|4000643

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IspE COG1947
4-diphosphocytidyl-2C-methyl-D-erythritol kinase [Lipid transport and metabolism]; ...
 1-282 2.28e-136

4-diphosphocytidyl-2C-methyl-D-erythritol kinase [Lipid transport and metabolism]; 4-diphosphocytidyl-2C-methyl-D-erythritol kinase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


:

Pssm-ID: 441550 [Multi-domain]  Cd Length: 281  Bit Score: 386.02  E-value: 2.28e-136
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504427708   1 MIYETAPAKINLTLDTLYKRDDGYHEVEMIMTTIDLSDRLSFEKRNDSRIVLKVDETFIPSDDRNLAYRAALLMKETYQI 80
Cdd:COG1947    1 SLTVKAPAKINLFLHVTGRRPDGYHELETVFQFIDLGDTLTIEPADDGSISLTGPGAGVPTDEDNLVYRAARLLQEATGI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504427708  81 KQGVTITLEKNIPVAAGLAGGSSDAAATMRGMNRLFELNRSLDELSELSAAIGSDVPFCVYGTTALCKGRGEILEILPKT 160
Cdd:COG1947   81 PPGVDIHLEKRIPVGAGLGGGSSDAAATLRALNRLWGLGLSREELAELAAKLGADVPFFLYGGTALAEGRGEKLTPLPPL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504427708 161 PSAWVIVAKPQAGLSTPEIYGGLDLSQPFP-VHTEQCLKAIEENDyDALCKSLSNRLEPVSMQLQPEIAKIKTNMLNNGA 239
Cdd:COG1947  161 PELWLVLVKPGVGVSTAEVYRALDLTRDTPpPDIDALLAALAAGD-AALAALLRNDLEPVAFKLYPEIAEVLEALLEAGA 239

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 504427708 240 DGALMSGSGPTVYGFAQRERQARHIFNAVSGCCnDVYLVRTLG 282
Cdd:COG1947  240 LAARMSGSGSTVFGLFEDEEAAEAAAAALPARG-GVFVARTLN 281
 
Name Accession Description Interval E-value
IspE COG1947
4-diphosphocytidyl-2C-methyl-D-erythritol kinase [Lipid transport and metabolism]; ...
 1-282 2.28e-136

4-diphosphocytidyl-2C-methyl-D-erythritol kinase [Lipid transport and metabolism]; 4-diphosphocytidyl-2C-methyl-D-erythritol kinase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 441550 [Multi-domain]  Cd Length: 281  Bit Score: 386.02  E-value: 2.28e-136
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504427708   1 MIYETAPAKINLTLDTLYKRDDGYHEVEMIMTTIDLSDRLSFEKRNDSRIVLKVDETFIPSDDRNLAYRAALLMKETYQI 80
Cdd:COG1947    1 SLTVKAPAKINLFLHVTGRRPDGYHELETVFQFIDLGDTLTIEPADDGSISLTGPGAGVPTDEDNLVYRAARLLQEATGI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504427708  81 KQGVTITLEKNIPVAAGLAGGSSDAAATMRGMNRLFELNRSLDELSELSAAIGSDVPFCVYGTTALCKGRGEILEILPKT 160
Cdd:COG1947   81 PPGVDIHLEKRIPVGAGLGGGSSDAAATLRALNRLWGLGLSREELAELAAKLGADVPFFLYGGTALAEGRGEKLTPLPPL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504427708 161 PSAWVIVAKPQAGLSTPEIYGGLDLSQPFP-VHTEQCLKAIEENDyDALCKSLSNRLEPVSMQLQPEIAKIKTNMLNNGA 239
Cdd:COG1947  161 PELWLVLVKPGVGVSTAEVYRALDLTRDTPpPDIDALLAALAAGD-AALAALLRNDLEPVAFKLYPEIAEVLEALLEAGA 239

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 504427708 240 DGALMSGSGPTVYGFAQRERQARHIFNAVSGCCnDVYLVRTLG 282
Cdd:COG1947  240 LAARMSGSGSTVFGLFEDEEAAEAAAAALPARG-GVFVARTLN 281
ispE TIGR00154
4-diphosphocytidyl-2C-methyl-D-erythritol kinase; Members of this family of GHMP kinases were ...
 6-282 3.42e-94

4-diphosphocytidyl-2C-methyl-D-erythritol kinase; Members of this family of GHMP kinases were previously designated as conserved hypothetical protein YchB or as isopentenyl monophosphate kinase. It is now known, in tomato and E. coli, to encode 4-diphosphocytidyl-2C-methyl-D-erythritol kinase, an enzyme of the deoxyxylulose phosphate pathway of terpenoid biosynthesis. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other]


Pssm-ID: 188029 [Multi-domain]  Cd Length: 294  Bit Score: 279.78  E-value: 3.42e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504427708    6 APAKINLTLDTLYKRDDGYHEVEMIMTTIDLSDRLSFEKRNDSRIVLKVDETFIPSDDrNLAYRAALLMKETY----QIK 81
Cdd:TIGR00154   7 APAKINLFLYILGKRPDGYHELQMLMQFIDLGDKIIISVRSDDDIRLLKGDFDVPLEE-NLAYRAAQLLKNFAnskiKSL 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504427708   82 QGVTITLEKNIPVAAGLAGGSSDAAATMRGMNRLFELNRSLDELSELSAAIGSDVPFCVYGTTALCKGRGEILEILPKTP 161
Cdd:TIGR00154  86 DGVNIEITKNIPMAAGLGGGSSDAAAVLVGLNQLWNLGLSLEELAELGATLGADVPFFVSGGTAFATGRGEIITPFEDPP 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504427708  162 SAWVIVAKPQAGLSTPEIYGGLDLSQPFPVHTEQCLKAIEENDYDALCKSLSNRLEPVSMQLQPEIAKIKTNMLNNGADG 241
Cdd:TIGR00154 166 EKWVVIAKPHVSVSTPVVYQAYKLPRNTPKRAKEWLKKISLECLQLLDSNGLNDLEKVALKRHTEVAQALNWLLEYGLAP 245

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 504427708  242 ALMSGSGPTVYGFAQRERQARHIFN----AVSGCCNDVYLVRTLG 282
Cdd:TIGR00154 246 ERMSGSGPCVFALFDMESEAEQVLEqapeWLNGFVAKGYNVSPIG 290
PRK03188 PRK03188
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional
 5-251 2.37e-67

4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional


Pssm-ID: 235110 [Multi-domain]  Cd Length: 300  Bit Score: 211.29  E-value: 2.37e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504427708   5 TAPAKINLTLDTLYKRDDGYHEVEMIMTTIDLSDRLSFekRNDSRIVLKV---DETFIPSDDRNLAYRAALLMKETYQIK 81
Cdd:PRK03188   4 RAPAKVNLHLGVGPLRDDGYHELATVFQAVSLYDEVTV--TAADVLSVEVsgeGADQVPTDESNLAWRAAELLAEHVGRA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504427708  82 QGVTITLEKNIPVAAGLAGGSSDAAATMRGMNRLFELNRSLDELSELSAAIGSDVPFCVYGTTALCKGRGEIL-EILPKT 160
Cdd:PRK03188  82 PDVHLHIDKGIPVAGGMAGGSADAAAALVACDALWGLGLSRDELLELAAELGSDVPFALLGGTALGTGRGEQLaPVLARG 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504427708 161 PSAWVIVAKPQaGLSTPEIYGGLD-----LSQPFPVHTEQCLKAIEENDYDALCKSLSNRLEPVSMQLQPEIAKIKTNML 235
Cdd:PRK03188 162 TFHWVLAFADG-GLSTPAVFRELDrlreaGDPPRLGEPDPLLAALRAGDPAQLAPLLGNDLQAAALSLRPSLRRTLRAGE 240

                        250
                 ....*....|....*.
gi 504427708 236 NNGADGALMSGSGPTV 251
Cdd:PRK03188 241 EAGALAGIVSGSGPTC 256
GHMP_kinases_N pfam00288
GHMP kinases N terminal domain; This family includes homoserine kinases, galactokinases and ...
 85-142 1.05e-14

GHMP kinases N terminal domain; This family includes homoserine kinases, galactokinases and mevalonate kinases.


Pssm-ID: 395225 [Multi-domain]  Cd Length: 64  Bit Score: 67.19  E-value: 1.05e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 504427708   85 TITLEKNIPVAAGLAGGSSDAAATMRGMNRLF-----ELNRSLDELSELSAAIGSDVPFCVYG 142
Cdd:pfam00288   1 DIEIESNIPLGAGLGSSAALAVALLLALNELFglplaKLALEAEELAGGGRGGGMDVAASLYG 63
 
Name Accession Description Interval E-value
IspE COG1947
4-diphosphocytidyl-2C-methyl-D-erythritol kinase [Lipid transport and metabolism]; ...
 1-282 2.28e-136

4-diphosphocytidyl-2C-methyl-D-erythritol kinase [Lipid transport and metabolism]; 4-diphosphocytidyl-2C-methyl-D-erythritol kinase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 441550 [Multi-domain]  Cd Length: 281  Bit Score: 386.02  E-value: 2.28e-136
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504427708   1 MIYETAPAKINLTLDTLYKRDDGYHEVEMIMTTIDLSDRLSFEKRNDSRIVLKVDETFIPSDDRNLAYRAALLMKETYQI 80
Cdd:COG1947    1 SLTVKAPAKINLFLHVTGRRPDGYHELETVFQFIDLGDTLTIEPADDGSISLTGPGAGVPTDEDNLVYRAARLLQEATGI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504427708  81 KQGVTITLEKNIPVAAGLAGGSSDAAATMRGMNRLFELNRSLDELSELSAAIGSDVPFCVYGTTALCKGRGEILEILPKT 160
Cdd:COG1947   81 PPGVDIHLEKRIPVGAGLGGGSSDAAATLRALNRLWGLGLSREELAELAAKLGADVPFFLYGGTALAEGRGEKLTPLPPL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504427708 161 PSAWVIVAKPQAGLSTPEIYGGLDLSQPFP-VHTEQCLKAIEENDyDALCKSLSNRLEPVSMQLQPEIAKIKTNMLNNGA 239
Cdd:COG1947  161 PELWLVLVKPGVGVSTAEVYRALDLTRDTPpPDIDALLAALAAGD-AALAALLRNDLEPVAFKLYPEIAEVLEALLEAGA 239

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 504427708 240 DGALMSGSGPTVYGFAQRERQARHIFNAVSGCCnDVYLVRTLG 282
Cdd:COG1947  240 LAARMSGSGSTVFGLFEDEEAAEAAAAALPARG-GVFVARTLN 281
ispE TIGR00154
4-diphosphocytidyl-2C-methyl-D-erythritol kinase; Members of this family of GHMP kinases were ...
 6-282 3.42e-94

4-diphosphocytidyl-2C-methyl-D-erythritol kinase; Members of this family of GHMP kinases were previously designated as conserved hypothetical protein YchB or as isopentenyl monophosphate kinase. It is now known, in tomato and E. coli, to encode 4-diphosphocytidyl-2C-methyl-D-erythritol kinase, an enzyme of the deoxyxylulose phosphate pathway of terpenoid biosynthesis. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other]


Pssm-ID: 188029 [Multi-domain]  Cd Length: 294  Bit Score: 279.78  E-value: 3.42e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504427708    6 APAKINLTLDTLYKRDDGYHEVEMIMTTIDLSDRLSFEKRNDSRIVLKVDETFIPSDDrNLAYRAALLMKETY----QIK 81
Cdd:TIGR00154   7 APAKINLFLYILGKRPDGYHELQMLMQFIDLGDKIIISVRSDDDIRLLKGDFDVPLEE-NLAYRAAQLLKNFAnskiKSL 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504427708   82 QGVTITLEKNIPVAAGLAGGSSDAAATMRGMNRLFELNRSLDELSELSAAIGSDVPFCVYGTTALCKGRGEILEILPKTP 161
Cdd:TIGR00154  86 DGVNIEITKNIPMAAGLGGGSSDAAAVLVGLNQLWNLGLSLEELAELGATLGADVPFFVSGGTAFATGRGEIITPFEDPP 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504427708  162 SAWVIVAKPQAGLSTPEIYGGLDLSQPFPVHTEQCLKAIEENDYDALCKSLSNRLEPVSMQLQPEIAKIKTNMLNNGADG 241
Cdd:TIGR00154 166 EKWVVIAKPHVSVSTPVVYQAYKLPRNTPKRAKEWLKKISLECLQLLDSNGLNDLEKVALKRHTEVAQALNWLLEYGLAP 245

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 504427708  242 ALMSGSGPTVYGFAQRERQARHIFN----AVSGCCNDVYLVRTLG 282
Cdd:TIGR00154 246 ERMSGSGPCVFALFDMESEAEQVLEqapeWLNGFVAKGYNVSPIG 290
PRK03188 PRK03188
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional
 5-251 2.37e-67

4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional


Pssm-ID: 235110 [Multi-domain]  Cd Length: 300  Bit Score: 211.29  E-value: 2.37e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504427708   5 TAPAKINLTLDTLYKRDDGYHEVEMIMTTIDLSDRLSFekRNDSRIVLKV---DETFIPSDDRNLAYRAALLMKETYQIK 81
Cdd:PRK03188   4 RAPAKVNLHLGVGPLRDDGYHELATVFQAVSLYDEVTV--TAADVLSVEVsgeGADQVPTDESNLAWRAAELLAEHVGRA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504427708  82 QGVTITLEKNIPVAAGLAGGSSDAAATMRGMNRLFELNRSLDELSELSAAIGSDVPFCVYGTTALCKGRGEIL-EILPKT 160
Cdd:PRK03188  82 PDVHLHIDKGIPVAGGMAGGSADAAAALVACDALWGLGLSRDELLELAAELGSDVPFALLGGTALGTGRGEQLaPVLARG 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504427708 161 PSAWVIVAKPQaGLSTPEIYGGLD-----LSQPFPVHTEQCLKAIEENDYDALCKSLSNRLEPVSMQLQPEIAKIKTNML 235
Cdd:PRK03188 162 TFHWVLAFADG-GLSTPAVFRELDrlreaGDPPRLGEPDPLLAALRAGDPAQLAPLLGNDLQAAALSLRPSLRRTLRAGE 240

                        250
                 ....*....|....*.
gi 504427708 236 NNGADGALMSGSGPTV 251
Cdd:PRK03188 241 EAGALAGIVSGSGPTC 256
PRK14608 PRK14608
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional
 1-264 1.35e-61

4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional


Pssm-ID: 237765 [Multi-domain]  Cd Length: 290  Bit Score: 196.23  E-value: 1.35e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504427708   1 MIYETAPAKINLTLDTLYKRDDGYHEVEMIMTTIDLSDRLSFEK-RNDSrivLKVDETF---IPSDDRNLAYRAA-LLMK 75
Cdd:PRK14608   6 SLTEFAPAKINLALHVTGRRADGYHLLESLVAFADVGDRLTLEPaEALS---LTVSGPFaagLGDGDDNLVLRAArALRA 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504427708  76 ETYQIKQGVTITLEKNIPVAAGLAGGSSDAAATMRGMNRLFELNRSLDELSELSAAIGSDVPFCVYGTTALCKGRGEILE 155
Cdd:PRK14608  83 RVGPGLPPGAFHLEKNLPVAAGIGGGSADAAAALRLLARLWGLALDDERLAALALSLGADVPVCLDSRPLIMRGIGEELT 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504427708 156 ILPKTPSAWVIVAKPQAGLSTPEIYGGLDLsqpfPVHTEQCLKAIEENDYDALCKSLS---NRLEPVSMQLQPEIAKIKT 232
Cdd:PRK14608 163 PLPGLPSLPAVLVNPGVPVATPDVFRALGL----RDGPPLPGAPDPLASADALLAALAatrNDLEPPALALAPVIGEVLA 238

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 504427708 233 nMLnNGADGAL---MSGSGPTVYG----FAQRERQARHI 264
Cdd:PRK14608 239 -AL-RAQPGALlarMSGSGATCFAlfadEAAAEAAAAAI 275
PRK14611 PRK14611
4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase;
1-260 1.17e-50

4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase;


Pssm-ID: 184767 [Multi-domain]  Cd Length: 275  Bit Score: 167.62  E-value: 1.17e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504427708   1 MIYETAPAKINLTLDTLYKRDDGYHEVEMIMTTIDLSDRLSFEKRNdsriVLKVdETFIP--SDDRNLAYRAALLMKETY 78
Cdd:PRK14611   1 MEVLLSPAKVNLGLWILGKRPDGYHEIFTIYHTIDLYDRIYIKEHH----TLEV-KTSSPqiKEEENIVYKALRLFERYT 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504427708  79 QIKQGVTITLEKNIPVAAGLAGGSSDAAATMRGMNRLFELNRSLDELSELSAAIGSDVPFCVYGTTALCKGRGEILEILP 158
Cdd:PRK14611  76 GIDINYSIFIEKNIPVGAGLGGGSSNAAVVLKYLNELLGNPLSEEELFELASSISADAPFFLKGGFALGRGIGDKLEFLE 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504427708 159 KTPSAWVIVAKPQAGLSTPEIYGGLD---LSQPFPVH-TEQCLKAIEENDYDALcksLSNRLEPVSMQLQPEIAKIkTNM 234
Cdd:PRK14611 156 KPISREITLVYPNIKSSTGRVYSKVTkqiLTNKEDLNiIISLLREGEEKKIEEV---IENTLGEIALELYPEIKEV-YRF 231

                        250       260
                 ....*....|....*....|....*.
gi 504427708 235 LNNGADGALMSGSGPTVYGFAQRERQ 260
Cdd:PRK14611 232 LEYLGYKPFVSGSGSSVYVFGKPSEE 257
PRK14613 PRK14613
4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase;
6-258 5.81e-38

4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase;


Pssm-ID: 173077 [Multi-domain]  Cd Length: 297  Bit Score: 135.41  E-value: 5.81e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504427708   6 APAKINLTLDTLYKRDDGYHEVEMIMTTIDLSDRLS--------FEKRNDSRIVLKVDETFIPSDDR-----NLAYRAAL 72
Cdd:PRK14613   3 SPAKINLGLEIPFKREDGFHEIRSVFLKISWGDDIEiepapngvFELFSTNEIILEKRKLYDQVSERgdikqNILYKTFI 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504427708  73 LMKETYQIKQGVTITLEKNIPVAAGLAGGSSDAAATMRGMNRLFELNRSlDELSELSAAIGSDVPFCVYGTTALCKGRGE 152
Cdd:PRK14613  83 KARSLFPELPGVKIHLTKRISPAGGLGGGSTNAASLLNFLFSWRNFFTS-DEMQVFAKEIGSDVPFFLGEGHAFVTGKGE 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504427708 153 ILEILPKTPSAWVIVAKPQaGLSTPEIYGGLD--LSQPFPVH-----TEQCLKAIEENDYDALCKSLSNRLEPVSMQLQP 225
Cdd:PRK14613 162 IMEEIEVHKGQGILALTPQ-VMNTGEMYALLKkpLQESASQKngntlSEDLISSLKVGDWVSLQGRLENDFEPVAFQLHP 240

                        250       260       270
                 ....*....|....*....|....*....|...
gi 504427708 226 EIAKIKTNMLNNGADGALMSGSGPTVYGFAQRE 258
Cdd:PRK14613 241 ELGVLKDKFLEFGSSYCSLTGSGSSMYGLVQGL 273
ThrB COG0083
Homoserine kinase [Amino acid transport and metabolism]; Homoserine kinase is part of the ...
 34-262 1.31e-27

Homoserine kinase [Amino acid transport and metabolism]; Homoserine kinase is part of the Pathway/BioSystem: Threonine biosynthesis


Pssm-ID: 439853 [Multi-domain]  Cd Length: 302  Bit Score: 108.26  E-value: 1.31e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504427708  34 IDLSDRLSFEKRNDSRIVLKV---DETFIPSDDRNLAYRAAL-LMKETYQIKQGVTITLEKNIPVAAGLagGSSDAA--A 107
Cdd:COG0083   25 LSLYDEVEVERSDEPGLEIEIegeGADELPTDEDNLVYQAALaLLEKLGKEPPGLRIEIEKGIPLGRGL--GSSAAAivA 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504427708 108 TMRGMNRLFELNRSLDELSELSAAI-G-SD--VPfCVYGTTALCKGRGEILEILPKTPSA--WVIVAKPQAGLST----- 176
Cdd:COG0083  103 GLVAANALLGLPLSKEELLELATEGeGhPDnvAP-ALLGGLVLSRSDGEPVRVVRLPVPPdlKAVVVIPDFELSTkeara 181

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504427708 177 --PEIYggldlsqPFPVHTEQC------LKAIEENDYDALCKSLSNRL-EPVSMQLQPEIAKIKTNMLNNGADGALMSGS 247
Cdd:COG0083  182 vlPKQV-------PLKDAVFNSsraallVAALATGDYELLGRAMEDRLhEPYRAKLIPGFDEVKEAALEAGALGAGISGA 254

                        250
                 ....*....|....*
gi 504427708 248 GPTVYGFAQRERQAR 262
Cdd:COG0083  255 GPTVLALADDEEAEA 269
PRK04181 PRK04181
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional
 8-260 2.68e-24

4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional


Pssm-ID: 235243  Cd Length: 257  Bit Score: 98.11  E-value: 2.68e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504427708   8 AKINLTLDTLYKRDDgYHEVEMIMTTI-DLSDRLSFEKRNDSRIVLKVDetFIPSDDRNLAYRA--ALLM----KETYQI 80
Cdd:PRK04181   7 AKVNIFLKILGKRGN-YHELISRFVLVkDLFDEIEFVPKSAESFELIGN--FDCPLEENIIYKAyqELKNkgfsNELIEF 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504427708  81 KQGVTITLEKNIPVAAGLAGGSSDAAATMRGMNRLFELNRSLDELSELSAAIGSDVPFCVYG-TTALCKGRGEILEILPK 159
Cdd:PRK04181  84 FKKKAIEVEKNIPTGAGLGGGSSDAATFLLMLNEILNLKLSLEELAEIGSKVGADVAFFISGyKSANVSGIGEIVEEFEE 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504427708 160 TPSAWVIVAkPQAGLSTPEIY-----GGLDLSQPFPVHTEQCLKAIE-ENDYDAlcKSLSNRLEPvSMQLQPEIAKIKtn 233
Cdd:PRK04181 164 EILNLEIFT-PNIFCSTKAVYkayreEFYDFISFNQAKELLKLSSLElLKNFKN--TELNDLLAP-ALKLYPALKDYL-- 237

                        250       260
                 ....*....|....*....|....*..
gi 504427708 234 mlnngADGALMSGSGPTVygFAQRERQ 260
Cdd:PRK04181 238 -----GEDWFFSGSGSSF--FRVKRAQ 257
PRK01212 PRK01212
homoserine kinase; Provisional
 59-262 2.62e-21

homoserine kinase; Provisional


Pssm-ID: 234920 [Multi-domain]  Cd Length: 301  Bit Score: 90.98  E-value: 2.62e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504427708  59 IPSD-DRNLAYRAALLMKETYQIKQGVTITLEKNIPVAAGLagGSSDAA--ATMRGMNRLFELNRSLDELSELSAAIGS- 134
Cdd:PRK01212  56 LPLDpEKNLVYQAALKFLEKLGKPPGLRIELEKNIPLGRGL--GSSAASivAGLVAANELAGLPLSKEELLQLATEGEGh 133

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504427708 135 -D--VPfCVYG-TTALCKGRGEILEILPKTPSAWVIVAKPQAGLST-------PEIY------------GGLdlsqpfpV 191
Cdd:PRK01212 134 pDnvAP-ALLGgLVLALEENGVISVKIPVFDDLKWVVAIPNIELSTaearavlPKQYslkdavfnssraALL-------V 205

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 504427708 192 HteqclkAIEENDYDALCKSLSNRL-EPVSMQLQPEIAKIKTNMLNNGADGALMSGSGPTVYGFAQRERQAR 262
Cdd:PRK01212 206 A------ALYTGDYELAGRAMKDVLhEPYRAKLIPGFAEVRQAALEAGALGAGISGAGPTVFALCDKEDAEK 271
thrB TIGR00191
homoserine kinase; Homoserine kinase is part of the threonine biosynthetic pathway.Homoserine ...
 59-261 9.63e-16

homoserine kinase; Homoserine kinase is part of the threonine biosynthetic pathway.Homoserine kinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, Mevalonate kinase, Phosphomevalonate kinase) and shares with them an amino-terminal domain probably related to ATP binding.P.aeruginosa homoserine kinase seems not to be homologous (see PROSITE:PDOC0054) [Amino acid biosynthesis, Aspartate family]


Pssm-ID: 129295 [Multi-domain]  Cd Length: 302  Bit Score: 75.52  E-value: 9.63e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504427708   59 IPSD-DRNLAYRAALLMKETYQIKQ-GVTITLEKNIPVAAGLagGSSDAA--ATMRGMNRLFELNRSLDELSELSAAI-- 132
Cdd:TIGR00191  54 IPTEpTDNLIYQVAKRFLDQLGIRMpPVKVTLEKNIPLGRGL--GSSAAAivAALAAANELCGLPLSKERLLDYASELeg 131

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504427708  133 -GSDVPFCVYGTTALCKGRGEILEILP-KTPSAWVIV-AKPQAGLSTPEIYGGLdlsqPFPVHTEQCLK----------A 199
Cdd:TIGR00191 132 hPDNVAPALLGGFQLAFVEDDKLEVLKiPIFSKLDWVlAIPNIEVSTAEARAVL----PKAYPRQDLVFnlshlaglvhA 207

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 504427708  200 IEENDYDALCKSLSNRL-EPVSMQLQPEIAKIKTNMLNNGADGALMSGSGPTVYGFAQRERQA 261
Cdd:TIGR00191 208 IYQKKPDLGAIMMKDRIhQPYRESLIPNLFKIKQAALEKGAYGITISGSGPTILAMADEEFAE 270
GHMP_kinases_N pfam00288
GHMP kinases N terminal domain; This family includes homoserine kinases, galactokinases and ...
 85-142 1.05e-14

GHMP kinases N terminal domain; This family includes homoserine kinases, galactokinases and mevalonate kinases.


Pssm-ID: 395225 [Multi-domain]  Cd Length: 64  Bit Score: 67.19  E-value: 1.05e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 504427708   85 TITLEKNIPVAAGLAGGSSDAAATMRGMNRLF-----ELNRSLDELSELSAAIGSDVPFCVYG 142
Cdd:pfam00288   1 DIEIESNIPLGAGLGSSAALAVALLLALNELFglplaKLALEAEELAGGGRGGGMDVAASLYG 63
PRK05905 PRK05905
4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase;
1-254 3.05e-14

4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase;


Pssm-ID: 235642  Cd Length: 258  Bit Score: 70.65  E-value: 3.05e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504427708   1 MIYETAPaKINLTLdTLYKRDDGY--HEVEMIMTTI-DLSDRLSFEKRNDSRIVLK----VDETFIPSDD---RNLAYra 70
Cdd:PRK05905   1 MKYKSYA-KINLGL-SIYKKCKKVtkHKLESIFILVeNVYDDIEIEKIEKNIDDIHyfdeTNEILVYSRLilvKTLEW-- 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504427708  71 allMKETYQIKQGVTITLEKNIPVAAGLAGGSSDAAATmrgMNRLFELnRSLDELS--ELSAAIGSDVPFCVYG-TTALC 147
Cdd:PRK05905  77 ---LRDKYNIKNHFKIKIKKRIPIGSGLGSGSSNAAVL---MKWILEF-EGINEINykDVVNKLGSDIPFFLSGyKTAYI 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504427708 148 KGRGEILE--ILPKTPSAWVIVAKPQAglSTPEIYGGLDLSQPFpvhTEQCLKAIEENDYDALCKSLSNRLEPVSMQLQP 225
Cdd:PRK05905 150 SDYGSQVEdlIGQFKLTYKVIFMNVNV--STKKVFEKFDDNQHV---IKNNFKTIIKNLKENIVVNIHNDLQEPCFELYP 224

                        250       260
                 ....*....|....*....|....*....
gi 504427708 226 EIaKIKTNMLNNGADGALMSGSGPTVYGF 254
Cdd:PRK05905 225 NL-LYKYNELLNDGFYTILSGAGSSFIVI 252
PRK03926 PRK03926
mevalonate kinase; Provisional
 1-143 2.96e-09

mevalonate kinase; Provisional


Pssm-ID: 179677 [Multi-domain]  Cd Length: 302  Bit Score: 56.60  E-value: 2.96e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504427708   1 MIYETAPAKINLTldtlykrddGYHEV----EMIMTTIDLsdrlsfekRNDSRIVLKVDETFIPSD-----DRNLAYRAA 71
Cdd:PRK03926   1 MVLCSAPGKIYLF---------GEHAVvygkPAIACAIDL--------RTYVRAEFNDDSIYIESDygktgEKHPYVSAA 63

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 504427708  72 L-LMKETYQIkQGVTITLEKNIPVAAGLagGSSDAA--ATMRGMNRLFELNRSLDELselsAAIGSDVPFCVYGT 143
Cdd:PRK03926  64 IeKMREEADK-DGVTVSITSQIPVGSGL--GSSAAVtvATIGALNRLLGLGLSLEEI----AKLGHKVELLVQGA 131
ERG12 COG1577
Mevalonate kinase [Lipid transport and metabolism]; Mevalonate kinase is part of the Pathway ...
 30-248 5.57e-09

Mevalonate kinase [Lipid transport and metabolism]; Mevalonate kinase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 441185 [Multi-domain]  Cd Length: 277  Bit Score: 55.62  E-value: 5.57e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504427708  30 IMTTIDLSDRLSFEKRNDSRIVLKVDE-----TFIPSDDRNLAY-RAAL-LMKETYQIK-QGVTITLEKNIPVAAGLagG 101
Cdd:COG1577   20 IAVAVDRRATVTVEPSDDDKLRIESPDlggtlDLDPLADAALRYiKAAIeAALEYLGLPlKGFDIEIDSEIPRKRGL--G 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504427708 102 SSDA--AATMRGMNRLFELNRSLDELSELSAAI-------GS--DVPFCVYGTT-ALCKGRG-EILEiLPKTPSAWVI-- 166
Cdd:COG1577   98 SSAAvaVAVIRALAAFYGVELSKEELFKLALEAekivhgnPSglDTAASTYGGPiYYQRGDRaEPLE-LPKNLPLVVGdt 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504427708 167 ---------VAKPQAGLST-PEIYGGL--DLSQpfpvHTEQCLKAIEENDYDALCKSLS-NRlepvsMQLQ------PEI 227
Cdd:COG1577  177 gvpastkelVAKVRKLKERnPELYEAFleEIGD----LVEEAIEALEEGDLEALGELMNeNH-----GLLRalgvstPEL 247

                        250       260
                 ....*....|....*....|.
gi 504427708 228 AKIKTNMLNNGADGALMSGSG 248
Cdd:COG1577  248 DRLVEAARKAGALGAKLTGAG 268
GHMP_kinases_C pfam08544
GHMP kinases C terminal; This family includes homoserine kinases, galactokinases and ...
 197-269 2.09e-06

GHMP kinases C terminal; This family includes homoserine kinases, galactokinases and mevalonate kinases.


Pssm-ID: 430063 [Multi-domain]  Cd Length: 85  Bit Score: 44.77  E-value: 2.09e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504427708  197 LKAIEENDYDALCKSL-----SNRLEPVSMQLQPEIAKIKTNMLNNGAdGALMSGS--GPTVYGFAQRERQARHIFNAVS 269
Cdd:pfam08544   2 LEALLRGDLEELGKLLtesaeSLEPLLVVGILPPELDELLEALLELGL-GAKLSGSggGPTVFALFKDEDDAEEVARALR 80
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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