|
Name |
Accession |
Description |
Interval |
E-value |
| LeuS |
COG0495 |
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA ... |
1-860 |
0e+00 |
|
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440261 [Multi-domain] Cd Length: 826 Bit Score: 1612.03 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 1 MQEQYRPEEIESKVQQHWDEKRTFEVTEDESKEKYYCLSMLPYPSGRLHMGHVRNYTIGDVIARYQRMLGKNVLQPIGWD 80
Cdd:COG0495 1 MQERYNPKEIEKKWQKYWEENGTFKADEDSSKPKYYVLDMFPYPSGRLHMGHVRNYTIGDVVARYKRMQGYNVLHPMGWD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 81 AFGLPAEGAAVKNNTAPAPWTYDNIAYMKNQLKMLGFGYDWSRELATCTPEYYRWEQKFFTELYKKGLVYKKTSAVNWCP 160
Cdd:COG0495 81 AFGLPAENAAIKNGVHPAEWTYENIANMRRQLKRLGLSYDWSREIATCDPEYYKWTQWIFLQLYEKGLAYRKEAPVNWCP 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 161 NDQTVLANEQVIDGCCWRCDTKVERKEIPQWFIKITAYADELLNDLDTLDHWPDTVKTMQRNWIGRSEGVEITFNVENYD 240
Cdd:COG0495 161 VDQTVLANEQVIDGRCWRCGAPVEKKELPQWFLKITDYADELLDDLDKLDGWPEKVKTMQRNWIGRSEGAEVDFPVEGSD 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 241 QTLTVYTTRPDTFMGATYLAVAAGHPLAQKAA--ENNPELATFIDECRNTKVAEADMATMEKKGVATGFYAKHPLTGEAI 318
Cdd:COG0495 241 EKITVFTTRPDTLFGATFMVLAPEHPLVKELAtpEQNAAVAAFIEEAKKKSEIERTSETKEKTGVFTGLYAINPLTGEKI 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 319 PVWAANFVLMEYGTGAVMAVPGHDQRDYEFATKYNLPIKAVILAADGSEPDLSEQALTEKGTLFNSGEFSGLSFEDGFNA 398
Cdd:COG0495 321 PIWIADYVLMDYGTGAVMAVPAHDQRDFEFAKKYGLPIKQVIAPEDGDDPDILEEAYTGDGVLINSGEFDGLDSEEAKEA 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 399 IADKLASLGVGERKVNYRLRDWGVSRQRYWGAPIPMVTLEDGTVMPTPEDQLPVILPEDVVMDGI-TSPIKADPEWAKTT 477
Cdd:COG0495 401 IIEWLEEKGLGKRKVNYRLRDWLISRQRYWGEPIPIIHCEDCGVVPVPEDQLPVELPEDVDFDPTgGSPLARAPEWVNVT 480
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 478 --VNGQPALRETDTFDTFMESSWYYARYTCPQYQEGMLDSDAANYWLPVDIYIGGIEHAIMHLLYFRFFHKLMRDAGMVN 555
Cdd:COG0495 481 cpKCGGPARRETDTMDTFVDSSWYYLRYTDPHNDEAPFDPEAANYWLPVDQYIGGIEHAILHLLYARFFTKVLRDLGLVS 560
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 556 SDEPAKQLLCQGMVLAdafyyVGANGErnwvspvdaiverdekgrivkakdaeghelVYTGMSKMSKSKNNGIDPQVMVE 635
Cdd:COG0495 561 FDEPFKRLLTQGMVLE-----VGKDGV------------------------------VIGGIEKMSKSKGNVVDPDEIIE 605
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 636 RYGADTVRLFMMFASPADMTLEWQESGVEGANRFLKRVWKLVYEHTaqgDAPALNVAALTEDQQALRRDVHKTIAKVTDD 715
Cdd:COG0495 606 KYGADTLRLFEMFAGPPERDLEWSDSGVEGAYRFLNRVWRLVVDEA---EALKLDVADLSEADKELRRALHKTIKKVTED 682
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 716 IGrRQTFNTAIAAIMELMNKLAKAPQEGEQDRALMREALLAVVRMLNPFTPHVSFTLWQELKGEGDIDNAPWPVADESAM 795
Cdd:COG0495 683 IE-RLRFNTAIAALMELVNALYKAKDSGEADRAVLREALETLVLLLAPFAPHIAEELWERLGHEGSVADAPWPEADEAAL 761
|
810 820 830 840 850 860
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 504643979 796 VENTTLVVVQVNGKVRGKITVAVDATEEQVRERAGQEHLVAKYLEGVTVRKVIYVPGKLLNLVVG 860
Cdd:COG0495 762 VEDEVTIVVQVNGKVRGKIEVPADASKEELEAAALADEKVQKFLEGKTIRKVIVVPGKLVNIVVK 826
|
|
| leuS_bact |
TIGR00396 |
leucyl-tRNA synthetase, eubacterial and mitochondrial family; The leucyl-tRNA synthetases ... |
5-860 |
0e+00 |
|
leucyl-tRNA synthetase, eubacterial and mitochondrial family; The leucyl-tRNA synthetases belong to two families so broadly different that they are represented by separate models. This model includes both eubacterial and mitochondrial leucyl-tRNA synthetases. It generates higher scores for some valyl-tRNA synthetases than for any archaeal or eukaryotic cytosolic leucyl-tRNA synthetase. Note that the enzyme from Aquifex aeolicus is split into alpha and beta chains; neither chain is long enough to score above the trusted cutoff, but the alpha chain scores well above the noise cutoff. The beta chain must be found by a model and search designed for partial length matches. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273057 [Multi-domain] Cd Length: 842 Bit Score: 1453.42 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 5 YRPEEIESKVQQHWDEKRTFEVTEDESKEKYYCLSMLPYPSGRLHMGHVRNYTIGDVIARYQRMLGKNVLQPIGWDAFGL 84
Cdd:TIGR00396 1 YNHIEIEEKWQQKWDENKTFKVTDDSSKPKYYILSMFPYPSGALHMGHVRNYTITDVLSRYYRMKGYNVLHPIGWDAFGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 85 PAEGAAVKNNTAPAPWTYDNIAYMKNQLKMLGFGYDWSRELATCTPEYYRWEQKFFTELYKKGLVYKKTSAVNWCPNDQT 164
Cdd:TIGR00396 81 PAENAAIKRGIHPAKWTYENIANMKKQLQALGFSYDWDREIATCDPEYYKWTQWIFLELFEKGLAYVKEADVNWCPNDGT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 165 VLANEQVI-DGCCWRCDTKVERKEIPQWFIKITAYADELLNDLDTLDHWPDTVKTMQRNWIGRSEGVEITFNVENYDQTL 243
Cdd:TIGR00396 161 VLANEQVDsDGRSWRGDTPVEKKELKQWFLKITAYAEELLNDLEELDHWPESVKEMQRNWIGKSEGVEITFKIADHDEKI 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 244 TVYTTRPDTFMGATYLAVAAGHPLAQKAAENNPELATFIDECRNTKVAEADMATMEKKGVATGFYAKHPLTGEAIPVWAA 323
Cdd:TIGR00396 241 TVFTTRPDTIFGVTYLALAPEHPLVEKAAENNPKVAAFIKKILNKTVAERTKATKEKKGVDTGIKAIHPLTGEKIPIWVA 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 324 NFVLMEYGTGAVMAVPGHDQRDYEFATKYNLPIKAVILAADGSEPdlSEQALTEKGTLFNSGEFSGLSFEDGFNAIADKL 403
Cdd:TIGR00396 321 NYVLMEYGTGAVMGVPAHDERDFEFAQKYGLPIKPVIDPAEKDLS--LTAAYTEDGVLVNSGEFNGLNSSEARNAIIDML 398
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 404 ASLGVGERKVNYRLRDWGVSRQRYWGAPIPMVTLEDGTVMPTPEDQLPVILPEDVVMDGI-TSPIKADPEWAKTTVN--G 480
Cdd:TIGR00396 399 EKEGKGKRKVNYRLRDWGFSRQRYWGEPIPIIHCEDGGVVPVPEEDLPVILPEDVVYDGDgGSPLSRIPEWVNVTCPscG 478
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 481 QPALRETDTFDTFMESSWYYARYTCPQYQEGMLDSDAANYWLPVDIYIGGIEHAIMHLLYFRFFHKLMRDAGMVNSDEPA 560
Cdd:TIGR00396 479 KPALRETDTMDTFAGSSWYYLRYLDPKNTDGPFDKEKAEYWLPVDLYIGGIEHAILHLLYARFFHKFLRDIGYVNTKEPF 558
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 561 KQLLCQGMVLAdafYYVGANGErnwvSPVDAIVERDEKGrivkaKDAEGHELVYTGMSKMSKSKNNGIDPQVMVERYGAD 640
Cdd:TIGR00396 559 KKLINQGMVLG---FYYPPNGK----VPADVLTERDEKG-----KDKAGGELVYVGYEKMSKSKGNGIDPQEIVESYGAD 626
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 641 TVRLFMMFASPADMTLEWQESGVEGANRFLKRVWKLVYEHTAQGDAPALNVAALTEDQQALRRDVHKTIAKVTDDIGRRQ 720
Cdd:TIGR00396 627 ALRLFIMFMGPIAASLEWNESGLEGARRFLDRVWNLVYEITGELDAASLTVTALEEAQKELRRDVHKFLKKVTEDLEKRE 706
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 721 TFNTAIAAIMELMNKLAKAPQEgeqdrALMREALLAVVRMLNPFTPHVSFTLWQELK-GEGDIDNAPWPVADESAMVENT 799
Cdd:TIGR00396 707 SFNTAISAMMELLNKLYKAKKE-----ALMLEYLKGFVTVLSPFAPHLAEELWEKLGsEPFIIDNAKWPVVDETALVEDK 781
|
810 820 830 840 850 860
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 504643979 800 TLVVVQVNGKVRGKITVAVDATEEQVRERAGQEHLVAKYLEGVTVRKVIYVPGKLLNLVVG 860
Cdd:TIGR00396 782 TLIVVQVNGKFRAKITVPKDADEEQVEELAKQDPEVKKYLENKTIKKVIYVPGKLVNFVIK 842
|
|
| PLN02563 |
PLN02563 |
aminoacyl-tRNA ligase |
9-860 |
0e+00 |
|
aminoacyl-tRNA ligase
Pssm-ID: 178177 [Multi-domain] Cd Length: 963 Bit Score: 892.25 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 9 EIESKVQQHWDEKRTFEVTE--DESKEKYYCLSMLPYPSGR-LHMGHVRNYTIGDVIARYQRMLGKNVLQPIGWDAFGLP 85
Cdd:PLN02563 84 EIEPKWQRYWEENRTFRTPDdvDTSKPKFYVLDMFPYPSGAgLHVGHPEGYTATDILARYKRMQGYNVLHPMGWDAFGLP 163
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 86 AEGAAVKNNTAPAPWTYDNIAYMKNQLKMLGFGYDWSRELATCTPEYYRWEQKFFTELYKKGLVYKKTSAVNWCPNDQTV 165
Cdd:PLN02563 164 AEQYAIETGTHPKITTLKNIARFRSQLKSLGFSYDWDREISTTEPEYYKWTQWIFLQLLKRGLAYQAEVPVNWCPALGTV 243
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 166 LANEQVIDGCCWRCDTKVERKEIPQWFIKITAYADELLNDLDTLDhWPDTVKTMQRNWIGRSEGVEITFNVENY-----D 240
Cdd:PLN02563 244 LANEEVVDGLSERGGHPVIRKPMRQWMLKITAYADRLLEDLDDLD-WPESIKEMQRNWIGRSEGAELDFSVLDGegkerD 322
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 241 QTLTVYTTRPDTFMGATYLAVAAGHPLAQKAAenNPELATFIDECRNTKVAEADM----ATMEKKGVATGFYAKHPLTGE 316
Cdd:PLN02563 323 EKITVYTTRPDTLFGATYLVVAPEHPLLSSLT--TAEQKEAVEEYVDAASRKSDLerteLQKEKTGVFTGSYAINPATGE 400
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 317 AIPVWAANFVLMEYGTGAVMAVPGHDQRDYEFATKYNLPIKAVILAADGSEPDlSEQALTEKGTLFNSGE----FSGLSF 392
Cdd:PLN02563 401 AIPIWVADYVLGSYGTGAIMAVPAHDTRDFEFAQKFDLPIKWVVKPADGNEDD-AEKAYTGEGVIVNSSSsgldINGLSS 479
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 393 EDGFNAIADKLASLGVGERKVNYRLRDWGVSRQRYWGAPIPMVTLED-GTVMPTPEDQLPVILPEdvvMDGIT------S 465
Cdd:PLN02563 480 KEAAKKVIEWLEETGNGKKKVNYKLRDWLFARQRYWGEPIPVVFLEDsGEPVPVPESDLPLTLPE---LDDFTptgtgeP 556
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 466 PIKADPEWAKTT--VNGQPALRETDTFDTFMESSWYYARYTCPQYQEGMLDSDAANYWLPVDIYIGGIEHAIMHLLYFRF 543
Cdd:PLN02563 557 PLAKAVSWVNTVdpSSGKPARRETNTMPQWAGSCWYYLRFMDPKNSNALVDKEKEKYWMPVDLYVGGAEHAVLHLLYARF 636
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 544 FHKLMRDAGMVNSDEPAKQLLCQGMVLADAFYYVGANGERNWVSPVDAIVERDEKGRIVKA----KDAEGHEL------- 612
Cdd:PLN02563 637 WHKVLYDIGVVSTKEPFQCLVNQGMILGEVEYTAFKDSDGEYVSADTADRLGELQQEKIPEekviKSGDSFVLkddpsir 716
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 613 VYTGMSKMSKSKNNGIDPQVMVERYGADTVRLFMMFASPADMTLEWQESGVEGANRFLKRVWKLVYEHTAQGDA-PALNV 691
Cdd:PLN02563 717 LIARAHKMSKSRGNVVNPDDVVSEYGADSLRLYEMFMGPLRDSKTWSTSGVEGVHRFLGRTWRLVVGAPLPDGSfRDGTV 796
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 692 AALTEDQQALRRDVHKTIAKVTDDI-GRRqtFNTAIAAIMELMN---KLAKAPqegeqdralmREALLAVVRMLNPFTPH 767
Cdd:PLN02563 797 VTDEEPSLEQLRLLHKCIAKVTEEIeSTR--FNTAISAMMEFTNaayKWDKVP----------REAIEPFVLLLSPYAPH 864
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 768 VSFTLWQELKGEGDIDNAPWPVADESAMVENTTLVVVQVNGKVRGKITVAVDATEEQVRERAGQEHLVAKYLEGVTVRKV 847
Cdd:PLN02563 865 LAEELWFRLGHSNSLAYEPWPEANPSYLVDDTVVLPVQINGKTRGTIEVEEGCSEDDAFALASQDEKLSKYLDGKEIKKR 944
|
890
....*....|...
gi 504643979 848 IYVPGKLLNLVVG 860
Cdd:PLN02563 945 IYVPGKILNVILK 957
|
|
| LeuRS_core |
cd00812 |
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic ... |
34-658 |
2.47e-119 |
|
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. In Aquifex aeolicus, the gene encoding LeuRS is split in two, just before the KMSKS motif. Consequently, LeuRS is a heterodimer, which likely superimposes with the LeuRS monomer found in most other organisms. LeuRS has an insertion in the core domain, which is subject to both deletions and rearrangements and thus differs between prokaryotic LeuRS and archaeal/eukaryotic LeuRS. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173906 [Multi-domain] Cd Length: 314 Bit Score: 364.26 E-value: 2.47e-119
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 34 KYYCLSMLPYPSGRLHMGHVRNYTIGDVIARYQRMLGKNVLQPIGWDAFGLPAEGAAVKNNTAPAPWTYDNIAYMKNQLK 113
Cdd:cd00812 1 KFYILVMFPYPSGALHVGHVRTYTIGDIIARYKRMQGYNVLFPMGFDAFGLPAENAAIKIGRDPEDWTEYNIKKMKEQLK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 114 MLGFGYDWSRELATCTPEYYRWEQKFFTELYKKGLVYKKTSAVNWCpndqtvlaneqvidgccwrcdtkverKEIPQWFI 193
Cdd:cd00812 81 RMGFSYDWRREFTTCDPEYYKFTQWLFLKLYEKGLAYKKEAPVNWC--------------------------KLLDQWFL 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 194 KI--TAYADELlndLDTLDhwpdtvktmqrNWIGRSEGVEITFnvenydqtltvyttrpdtfmgatylavaaghplaqka 271
Cdd:cd00812 135 KYseTEWKEKL---LKDLE-----------KLDGWPEEVRAMQ------------------------------------- 163
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 272 aennpelatfidecrntkvaeadmatmekkgvatgfyakhpltgeaipvwaanfvlmeygtgavmavpghdqrdyefatk 351
Cdd:cd00812 --------------------------------------------------------------------------------
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 352 ynlpikavilaadgsepdlseqaltekgtlfnsgefsglsfedgfnaiadklaslgvgerkvnyrlRDW-GVSRQRYWGA 430
Cdd:cd00812 164 ------------------------------------------------------------------ENWiGCSRQRYWGT 177
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 431 PIPMvtledgtvmptpedqlpvilpedvvmdgitspikadpewakttvngqpalreTDTFDTFMESSWYYARYTCPQYQE 510
Cdd:cd00812 178 PIPW----------------------------------------------------TDTMESLSDSTWYYARYTDAHNLE 205
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 511 GML------DSDAANYWLPVDIYIGGIEHAIMHLLYFRFFHKLMRDAGMVnSDEPAKQLLCQGMVLadafyyvgANGErn 584
Cdd:cd00812 206 QPYegdlefDREEFEYWYPVDIYIGGKEHAPNHLLYSRFNHKALFDEGLV-TDEPPKGLIVQGMVL--------LEGE-- 274
|
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 504643979 585 wvspvdaiverdekgrivkakdaeghelvytgmsKMSKSKNNGIDPQVMVERYGADTVRLFMMFASPADMTLEW 658
Cdd:cd00812 275 ----------------------------------KMSKSKGNVVTPDEAIKKYGADAARLYILFAAPPDADFDW 314
|
|
| tRNA-synt_1_2 |
pfam13603 |
Leucyl-tRNA synthetase, Domain 2; This is a family of the conserved region of Leucine-tRNA ... |
221-404 |
1.02e-115 |
|
Leucyl-tRNA synthetase, Domain 2; This is a family of the conserved region of Leucine-tRNA ligase or Leucyl-tRNA synthetase, EC:6.1.1.4.
Pssm-ID: 433342 [Multi-domain] Cd Length: 185 Bit Score: 349.54 E-value: 1.02e-115
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 221 RNWIGRSEGVEITFNVENYDQTLTVYTTRPDTFMGATYLAVAAGHPLAQKAAENNPELATFIDECRNTKVAEADMATMEK 300
Cdd:pfam13603 1 RNWIGRSEGAEITFPVEGTDEKIEVFTTRPDTLMGVTFVALAPEHPLVEKLAEKNPEVAAFIEECKNTSEIERTSETKEK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 301 KGVATGFYAKHPLTGEAIPVWAANFVLMEYGTGAVMAVPGHDQRDYEFATKYNLPIKAVILAADGSE-PDLSEQALTEKG 379
Cdd:pfam13603 81 EGVFTGLYAIHPITGEKIPIWIANFVLMEYGTGAVMAVPAHDQRDFEFAKKYNLPIKPVIQPEDGDLdLDIMTEAYTEEG 160
|
170 180
....*....|....*....|....*
gi 504643979 380 TLFNSGEFSGLSFEDGFNAIADKLA 404
Cdd:pfam13603 161 ILVNSGEFDGLDSEEAKEAIIKKLE 185
|
|
| valS |
TIGR00422 |
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase ... |
1-793 |
2.74e-94 |
|
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase and is particularly closely related to the isoleucyl tRNA synthetase. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273070 [Multi-domain] Cd Length: 861 Bit Score: 315.46 E-value: 2.74e-94
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 1 MQEQYRPEEIESKVQQHWDEKRTFEVTEDESKEKYYCLSMLPYPSGRLHMGHVRNYTIGDVIARYQRMLGKNVLQPIGWD 80
Cdd:TIGR00422 1 MPKDYDPHEVEKKWYKKWEKSGFFKPDGNSNKPPFCIDIPPPNVTGSLHIGHALNWSIQDIIARYKRMKGYNVLWLPGTD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 81 AFGLPAEGAAVKNNTAPAP----------------WTYDNIAYMKNQLKMLGFGYDWSRELATCTPEYYRWEQKFFTELY 144
Cdd:TIGR00422 81 HAGIATQVKVEKKLGAEGKtkhdlgreefrekiweWKEESGGTIKNQIKRLGASLDWSRERFTMDEGLSKAVKEAFVRLY 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 145 KKGLVYKKTSAVNWCPNDQTVLANEQvidgccwrcdtkVERKEIPQ--WFIKitayadellndldtldhwpdtvktmqrn 222
Cdd:TIGR00422 161 EKGLIYRGEYLVNWDPKLNTAISDIE------------VEYKEVKGklYYIR---------------------------- 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 223 wigrsegveitFNVENYD-QTLTVYTTRPDTFMGATYLAVaaghplaqkaaenNPElatfiDEcRNTkvaeadmaTMEKK 301
Cdd:TIGR00422 201 -----------YPLANGSkDYLVVATTRPETMFGDTAVAV-------------HPE-----DE-RYK--------HLIGK 242
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 302 gvatgfYAKHPLTGEAIPVWAANFVLMEYGTGAVMAVPGHDQRDYEFATKYNLPIKAVIlaadgsepdlseqalTEKGTL 381
Cdd:TIGR00422 243 ------KVILPLTGRKIPIIADEYVDMEFGTGAVKVTPAHDFNDYEWGKRHNLEFINIL---------------DEDGLL 301
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 382 F-NSGEFSGLSFEDGFNAIADKL-------------ASLGVGER------------------------------------ 411
Cdd:TIGR00422 302 NeNAGKYQGLTRFEARKKIVEDLkeegllvkiephtHNVGTCWRsgtvvepllskqwfvkvekladkaleaaeegeikfv 381
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 412 ----KVNYR-----LRDWGVSRQRYWGAPIPMVTledgtvmptpedqlpvILPEDVVMDGITSPIKADPEWAKTTVNGQP 482
Cdd:TIGR00422 382 pkrmEKRYLnwlrnIKDWCISRQLIWGHRIPVWY----------------CKECGEVYVAKEEPLPDDKTNTGPSVELEQ 445
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 483 alrETDTFDTFMeSSWYYARYTC--PQyqegmLDSDAANYWlPVDIYIGGieHAImhlLYFRFFHKLMRdaGMVNSDE-P 559
Cdd:TIGR00422 446 ---DTDVLDTWF-SSSLWPFSTLgwPD-----ETKDLKKFY-PTDLLVTG--YDI---IFFWVARMIFR--SLALTGQvP 508
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 560 AKQLLCQGMVladafyyvgangernwvspvdaiveRDEKGRivkakdaeghelvytgmsKMSKSKNNGIDPQVMVERYGA 639
Cdd:TIGR00422 509 FKEVYIHGLV-------------------------RDEQGR------------------KMSKSLGNVIDPLDVIEKYGA 545
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 640 DTVRLFMMFASPADMTLEWQESGVEGANRFLKRVW---KLVYEHTaqGDAPALNVAALTE---DQQALRRdVHKTIAKVT 713
Cdd:TIGR00422 546 DALRFTLASLVTPGDDINFDWKRVESARNFLNKLWnasRFVLMNL--SDDLELSGGEEKLslaDRWILSK-LNRTIKEVR 622
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 714 DDIGRRQtFNTAIAAIMEL-----------MNKLAKAPQEGEQDRAL---MREALLAVVRMLNPFTPHVSFTLWQELKGE 779
Cdd:TIGR00422 623 KALDKYR-FAEAAKALYEFiwndfcdwyieLVKYRLYNGNEAEKKAArdtLYYVLDKALRLLHPFMPFITEEIWQHFKEG 701
|
890
....*....|....*
gi 504643979 780 GD-IDNAPWPVADES 793
Cdd:TIGR00422 702 ADsIMLQSYPVVDAE 716
|
|
| valS |
PRK13208 |
valyl-tRNA synthetase; Reviewed |
1-853 |
1.68e-89 |
|
valyl-tRNA synthetase; Reviewed
Pssm-ID: 237306 [Multi-domain] Cd Length: 800 Bit Score: 300.96 E-value: 1.68e-89
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 1 MQEQYRPEEIESKVQQHWDEKRTFEVTEDESKEKYYCLSMLPYPSGRLHMGHVRNYTIGDVIARYQRMLGKNVLQPIGWD 80
Cdd:PRK13208 6 LPKKYDPEELEEKWQKIWEEEGTYKFDPDERKPVYSIDTPPPTVSGSLHIGHVFSYTHTDFIARYQRMRGYNVFFPQGWD 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 81 AFGLPAEgaaVK----NNTAPAP------------WTYDNIAYMKNQLKMLGFGYDWSRELATCTPEYYRWEQKFFTELY 144
Cdd:PRK13208 86 DNGLPTE---RKvekyYGIRKDDisreefielcreLTDEDEKKFRELWRRLGLSVDWSLEYQTISPEYRRISQKSFLDLY 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 145 KKGLVYKKTSAVNWCPNDQTVLAneqvidgccwrcDTKVERKEIPqwfikiTAYADellndldtldhwpdtvktmqrnwi 224
Cdd:PRK13208 163 KKGLIYRAEAPVLWCPRCETAIA------------QAEVEYRERE------GKLNY------------------------ 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 225 grsegveITFNVENyDQTLTVYTTRPDtFMGATyLAVAAghplaqkaaenNPElatfiDEcRNTKVAeadmatmekkgva 304
Cdd:PRK13208 201 -------IKFPVED-GEEIEIATTRPE-LLPAC-VAVVV-----------HPD-----DE-RYKHLV------------- 240
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 305 tGFYAKHPLTGEAIPVWAANFVLMEYGTGAVMAVPGHDQRDYEFATKYNLPIKAVIlaadgsepdlseqalTEKGTLF-N 383
Cdd:PRK13208 241 -GKTAIVPLFGVEVPILADPLVDPDFGTGAVMICTFGDKTDVTWWRELNLPTRIII---------------DEDGRMTeA 304
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 384 SGEFSGLSFEDGFNAIADKLASLG-VGE-----RKVN-----------------------------------------YR 416
Cdd:PRK13208 305 AGKLAGLTIEEARKKIVEDLKSGGlLGKqepikHNVKfcercdtpleilvtrqwfikvldlkeellergkeinwypehMR 384
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 417 LR----------DWGVSRQRYWGAPIPM-VTLEDGTVMPTPEDQLPVilpeDvvmdgitsPIKADPEWAKTTVNGQPALR 485
Cdd:PRK13208 385 VRlenwieglnwDWCISRQRYFGTPIPVwYCKDCGHPILPDEEDLPV----D--------PTKDEPPGYKCPQCGSPGFE 452
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 486 -ETDTFDTFMESSwyyaryTCPQYQEG-MLDSDAANYWLPVDIYIGGieHAIMhllyfRF--FHKLMRdAGMVNSDEPAK 561
Cdd:PRK13208 453 gETDVMDTWATSS------ITPLIVTGwERDEDLFEKVFPMDLRPQG--HDII-----RTwlFYTILR-AYLLTGKLPWK 518
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 562 QLLCQGMVLadafyyvgangernwvspvdaiverDEKGRivkakdaeghelvytgmsKMSKSKNNGIDPQVMVERYGADT 641
Cdd:PRK13208 519 NIMISGMVL-------------------------DPDGK------------------KMSKSKGNVVTPEELLEKYGADA 555
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 642 VRLFMMFASP-ADMTLEWQEsgVEGANRFLKRVW---KLVYehtAQGDAPALNVAALTE--DQQALRRdVHKTIAKVTDD 715
Cdd:PRK13208 556 VRYWAASARLgSDTPFDEKQ--VKIGRRLLTKLWnasRFVL---HFSADPEPDKAEVLEplDRWILAK-LAKVVEKATEA 629
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 716 IGRRQtFNTAIAAIM------------ELMNKLAKAPQEGEQD---RALMREALLAVVRMLNPFTPHVSFTLWQELKGeG 780
Cdd:PRK13208 630 LENYD-FAKALEEIEsffwhvfcddylELVKSRAYGEDEEEEQksaRYTLYTVLDTLLRLLAPFLPFITEEVWSWLYG-G 707
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 781 DIDNAPWPVADESAMVENTTLV---VVQVNGKVRG--------------KITVAVDATEEQVREragqehlVAKYLEGVT 843
Cdd:PRK13208 708 SVHRASWPEPDEELIDEEDEELgelAKEILSAVRKykseaglslnaplkKVEVYGPADLELLEA-------AEEDLKAAG 780
|
970
....*....|.
gi 504643979 844 -VRKVIYVPGK 853
Cdd:PRK13208 781 nIEELELVEGD 791
|
|
| valS |
PRK05729 |
valyl-tRNA synthetase; Reviewed |
1-794 |
1.41e-61 |
|
valyl-tRNA synthetase; Reviewed
Pssm-ID: 235582 [Multi-domain] Cd Length: 874 Bit Score: 224.21 E-value: 1.41e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 1 MQEQYRPEEIESKVQQHWDEKRTFEvTEDESKEKYyCLsMLPYP--SGRLHMGHVRNYTIGDVIARYQRMLGKNVL-QPi 77
Cdd:PRK05729 5 LPKTYDPKEVEAKWYQKWEEKGYFK-PDDNSKKPF-SI-VIPPPnvTGSLHMGHALNNTLQDILIRYKRMQGYNTLwLP- 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 78 GWDAFG----------LPAEG------------AAVKNntapapWT---YDNIaymKNQLKMLGFGYDWSRELATCTPEY 132
Cdd:PRK05729 81 GTDHAGiatqmvverqLAAEGksrhdlgrekflEKVWE------WKeesGGTI---TNQLRRLGASCDWSRERFTMDEGL 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 133 YRWEQKFFTELYKKGLVYKKTSAVNWCPNDQTVLANEQVidgccwrcdtkvERKEIPQ--WFIKitaYAdellndldtld 210
Cdd:PRK05729 152 SKAVREVFVRLYEKGLIYRGKRLVNWDPKLQTALSDLEV------------EYKEVKGklWHIR---YP----------- 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 211 hwpdtvktmqrnwigrsegveitfnVENYDQTLTVYTTRPDTFMGATYLAVaaghplaqkaaenNPElatfiDEcRNTKV 290
Cdd:PRK05729 206 -------------------------LADGSDYLVVATTRPETMLGDTAVAV-------------NPE-----DE-RYKHL 241
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 291 AeadmatmekkgvatGFYAKHPLTGEAIPVWAANFVLMEYGTGAVMAVPGHDQRDYEFATKYNLPIKAVIlaadgsepdl 370
Cdd:PRK05729 242 I--------------GKTVILPLVGREIPIIADEYVDPEFGTGAVKITPAHDPNDFEVGKRHNLPMINIM---------- 297
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 371 seqalTEKGTLF-NSGEFSGLSFEDGFNAIADKLASLGV-------------GER---------------KV-------- 413
Cdd:PRK05729 298 -----DEDGTINeNPGEYQGLDRFEARKAIVADLEELGLlvkiephthsvghSDRsgvviepylsdqwfvKMkplakpal 372
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 414 -----------------NYR-----LRDWGVSRQRYWGAPIPMVTLEDGTVMPTPEDqlpvilPEDVVMDGITspikadp 471
Cdd:PRK05729 373 eavengeikfvperwekTYFhwmenIQDWCISRQLWWGHRIPAWYDEDGEVYVGREE------PEAREKALLT------- 439
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 472 ewakttvngqpalRETDTFDT-FmeSS---------WyyarytcPQyqegmlDSDAANYWLPVDIYIGGieHAIMhllyf 541
Cdd:PRK05729 440 -------------QDEDVLDTwF--SSalwpfstlgW-------PE------KTEDLKRFYPTSVLVTG--FDII----- 484
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 542 rFFHklmrDAGMVNS------DEPAKQLLCQGMVladafyyvgangernwvspvdaiveRDEKGRivkakdaeghelvyt 615
Cdd:PRK05729 485 -FFW----VARMIMMglhftgQVPFKDVYIHGLV-------------------------RDEQGR--------------- 519
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 616 gmsKMSKSKNNGIDPQVMVERYGADTVRLFMMFASPADMTLEWQESGVEGANRFLKRVW---KLVYEHTAQGDAPAL-NV 691
Cdd:PRK05729 520 ---KMSKSKGNVIDPLDLIDKYGADALRFTLAALASPGRDIRFDEERVEGYRNFANKLWnasRFVLMNLEGADVGELpDP 596
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 692 AALT-EDQQALRRdVHKTIAKVTDDIGRRQtFNTAIAAIMEL-----------MNKLAKAPQEGEQDRALMREALLAVVR 759
Cdd:PRK05729 597 EELSlADRWILSR-LNRTVAEVTEALDKYR-FDEAARALYEFiwnefcdwyleLAKPVLQEAAKRATRATLAYVLEQILR 674
|
890 900 910
....*....|....*....|....*....|....*...
gi 504643979 760 MLNPFTPHVSFTLWQELKGEGDIDN---APWPVADESA 794
Cdd:PRK05729 675 LLHPFMPFITEELWQKLAPLGIEESimlAPWPEADEAI 712
|
|
| ileS |
TIGR00392 |
isoleucyl-tRNA synthetase; The isoleucyl tRNA synthetase (IleS) is a class I amino acyl-tRNA ... |
3-794 |
1.45e-61 |
|
isoleucyl-tRNA synthetase; The isoleucyl tRNA synthetase (IleS) is a class I amino acyl-tRNA ligase and is particularly closely related to the valyl tRNA synthetase. This model may recognize IleS from every species, including eukaryotic cytosolic and mitochondrial forms. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273054 [Multi-domain] Cd Length: 861 Bit Score: 224.18 E-value: 1.45e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 3 EQYRPEEIESKVQQHWDEKRTFEVTED--ESKEKYYCLSMLPYPSGRLHMGHVRNYTIGDVIARYQRMLGKNVLQPIGWD 80
Cdd:TIGR00392 4 MRGNLSKREEKILAFWQENDIFEKVKKlnKGKPEFIFHDGPPYANGSIHLGHALNKILKDIILRYKTMQGFNVTRKPGWD 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 81 AFGLPAEGAAVKNNtaPAPWTYD-------------------NIAYMKNQLKMLGFGYDWSRELATCTPEYYRWEQKFFT 141
Cdd:TIGR00392 84 THGLPIEHKVEKKL--GISGKKEissleieefrekcrefalkQIEEQREQFQRLGVWGDWENPYKTMDPSYEESQWWLFK 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 142 ELYKKGLVYKKTSAVNWCPNDQTVLANEQVIDGCCWRcdtkveRKEIPQWFIKITAYADELLNDLDTLDH---WPDTVKT 218
Cdd:TIGR00392 162 EAHEKGLLYRGLKPVYWSPRCRTALAEAEVEYKENYK------DVKDPSIYVKFPVKKDKKTYLKVKLSSlliWTTTPWT 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 219 MQRNwigrsegVEITFNVEnYDQTLTVYTTRPDTFMGATYLAvaagHPLAQKAAENNPELATFidecrntkvaeadmatm 298
Cdd:TIGR00392 236 LPSN-------LAIAVHPD-FEYALVQDNTKVEYFILAKKLV----EKLYNKAGSDYEIIKTF----------------- 286
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 299 ekKGVA-TGFYAKHPLTGEAIP-------VWAANFVLMEYGTGAVMAVPGHDQRDYEFATKYNLPI-------------- 356
Cdd:TIGR00392 287 --KGSDlEGLEYEHPLYDFVSQlkegapvVIGGDHVTTEDGTGIVHTAPGHGEEDYEIGKKYGLEVlspvdekgvytegv 364
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 357 -----KAVILAADG--SEPDLSEQALTEKGTLFNSGEFSG--------------LSFEDGF---NAIADK-LASLGvger 411
Cdd:TIGR00392 365 ndfqgRFVKDADKDiiKANKIIIEQLKDKGLLLKAEKITHsyphcwrtktpviyRATEQWFiktKDIKDQmLEQIK---- 440
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 412 KVNY-------RL-------RDWGVSRQRYWGAPIPMVTLEDGtvmptpeDQLPVI-----LPEDVVMDGITSPIKADP- 471
Cdd:TIGR00392 441 KVNWvpewgegRFgnwlenrPDWCISRQRYWGIPIPIWYCEDT-------GEPIVVgsieeLIELIELKGIDAWFEDLHr 513
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 472 ---EWAKTT-VNGQPALRETDTFDTFMES-SWYYARytcpqyQEGMLDSDAANYWLPVDIYIGGIEHaimhllYFRFFHK 546
Cdd:TIGR00392 514 dflDKITLKsGDGGEYRRVPDVLDVWFDSgSMPYAS------IHYPFENEKFKEVFPADFILEGSDQ------TRGWFYS 581
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 547 LMRDAGMVNSDEPAKQLLCQGMVLadafyyvgangernwvspvdaiverDEKGRivkakdaeghelvytgmsKMSKSKNN 626
Cdd:TIGR00392 582 SLAIGTALFGQAPYKNVITHGFTL-------------------------DEKGR------------------KMSKSLGN 618
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 627 GIDPQVMVERYGADTVRLFMMFASPADmTLEWQESGVEGANRFLKRVWKLVYE--------HTAQGDAPALNVAALT-ED 697
Cdd:TIGR00392 619 VVDPLKVINKYGADILRLYVASSDPWE-DLRFSDEILKQVVEKYRKIRWNTYRflltyanlDKFDPLFNSVAVEKFPeED 697
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 698 QQALRRdVHKTIAKVTDDIGRRQtFNTAIAAIMELMNK--------LAKAPQEGEQDRALMR-------EALLAVVRMLN 762
Cdd:TIGR00392 698 RWILSR-LNSLVEEVNEALEKYN-FHKVLRALQDFIVEelsnwyirIIRDRLYCEAKDNDKRaaqttlyYALLTLVRLLA 775
|
890 900 910
....*....|....*....|....*....|....*
gi 504643979 763 PFTPHVSFTLWQELKGEGD---IDNAPWPVADESA 794
Cdd:TIGR00392 776 PFLPHTAEEIYQNLPGGEEeesVHLNLWPEVDEEF 810
|
|
| tRNA-synt_1 |
pfam00133 |
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too ... |
13-651 |
7.62e-61 |
|
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too dissimilar to be included.
Pssm-ID: 459685 [Multi-domain] Cd Length: 602 Bit Score: 217.28 E-value: 7.62e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 13 KVQQHWDEKRTFEVTEDESKEK-YYCLSM-LPYPSGRLHMGHVRNYTIGDVIARYQRMLGKNVLQPIGWDAFGLPAEGAA 90
Cdd:pfam00133 1 QIYEFWDEQGYFKPELEKRKGKpSFTIHDgPPNATGSLHIGHALAKTLKDIVIRYKRMKGYYVLWVPGWDHHGLPTEQVV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 91 VKNNTAPAP-----------------WTYDNIAYMKNQLKMLGFGYDWSRELATCTPEYYRWEQKFFTELYKKGLVYKKT 153
Cdd:pfam00133 81 EKKLGIKEKktrhkygreefrekcreWKMEYADEIRKQFRRLGRSIDWDREYFTMDPELEAAVWEVFVRLHDKGLIYRGK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 154 SAVNWCPNDQTVLANeqvidgccwrcdTKVERKEI--PQWFIKITAYADEllndldtldhwpdtvktmqrnwigrsegve 231
Cdd:pfam00133 161 KLVNWSPALNTALSN------------LEVEYKDVkgPSIHVAFPLADDE------------------------------ 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 232 itfnvenyDQTLTVYTTRPDTFMGATYLAVaaghplaqkaaenNPELATFIDEcRNTKVAEADMATMEKKGVAT------ 305
Cdd:pfam00133 199 --------GASLVIWTTTPWTLPGNTAVAV-------------NPEFDYVITG-EGYILAEALLKSLYKKGTDKkiledf 256
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 306 ------GFYAKHPLTGEAIPVWAANFVLMEYGTGAVMAVPGHDQRDYEFATKYNLPIkAVILAADG----SEPDLSEQ-- 373
Cdd:pfam00133 257 rgkeleGKEAIHPFVNREIPIITDDYVDMEFGTGAVHIAPAHGENDYEVGQRHNLEV-INPVDDDGtfteEAPDFQGVyr 335
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 374 ---------ALTEKGTLFNSGEF---------SGLSFE----DGFNAIADKLASLGVGE-RKVNY--------------R 416
Cdd:pfam00133 336 fdarkkiveLLTEKGLLLKIEPFthsypfcwrSGTPIIpratPQWFVRMDELADQALEAvEKVQFvpksgekryfnwlaN 415
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 417 LRDWGVSRQRYWGAPIPMVTLEDGtvmptpedqlpvilpEDVVMDGITSPIKADPE--------WAKTTVN--GQPAL-- 484
Cdd:pfam00133 416 IQDWCISRQRWWGHPIPAWVSKDT---------------EEVVCRGELFELVAGRFeeegsikwLHREAKDklGYGKGtl 480
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 485 -RETDTFDTFMES-SWYYARYTCPQYQEGMLDSdaanyWLPVDIYIGGIEhaimhLLYFRFFHKLMRDAGMVNSdEPAKQ 562
Cdd:pfam00133 481 eQDEDVLDTWFSSgSWPFSTLGWPFVNTEEFKK-----FFPADMLLEGSD-----QTRGWFYRMIMLSTALTGS-VPFKN 549
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 563 LLCQGMVladafyyvgangernwvspvdaiveRDEKGRivkakdaeghelvytgmsKMSKSKNNGIDPQVMVERYGADTV 642
Cdd:pfam00133 550 VLVHGLV-------------------------RDEQGR------------------KMSKSLGNVIDPLDVIDKYGADAL 586
|
....*....
gi 504643979 643 RLFMMFASP 651
Cdd:pfam00133 587 RLWLANSDY 595
|
|
| ValS |
COG0525 |
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase ... |
1-795 |
2.62e-57 |
|
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440291 [Multi-domain] Cd Length: 877 Bit Score: 211.83 E-value: 2.62e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 1 MQEQYRPEEIESKVQQHWDEKRTFEVTEDESKEKYyCLsMLPYP--SGRLHMGHVRNYTIGDVIARYQRMLGKNVL-QPi 77
Cdd:COG0525 3 LPKTYDPKEVEAKWYQYWEENGYFKADPDSDKEPF-TI-VIPPPnvTGSLHMGHALNNTLQDILIRYKRMQGYNTLwQP- 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 78 GWDAFG----------LPAEG------------AAVknntapapW----TYDNIayMKNQLKMLGFGYDWSRELATCTPE 131
Cdd:COG0525 80 GTDHAGiatqavverqLAEEGksrhdlgrekflERV--------WewkeESGGT--ITNQLRRLGASCDWSRERFTMDEG 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 132 YYRWEQKFFTELYKKGLVYKKTSAVNWCPNDQTVLANEQVidgccwrcdtkvERKEIPQ--WFIKitaY--ADEllndld 207
Cdd:COG0525 150 LSKAVREVFVRLYEKGLIYRGKRLVNWDPKLKTALSDLEV------------EHEEVKGhlWHIR---YplADG------ 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 208 tldhwpdtvktmqrnwigrsegveitfnvenyDQTLTVYTTRPDTFMGATYLAVaaghplaqkaaenNPElatfiDEcRN 287
Cdd:COG0525 209 --------------------------------SGYIVVATTRPETMLGDTAVAV-------------HPE-----DE-RY 237
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 288 TKVAeadmatmekkgvatGFYAKHPLTGEAIPVWAANFVLMEYGTGAVMAVPGHDQRDYEFATKYNLPIKaVILAADGSe 367
Cdd:COG0525 238 KHLI--------------GKTVILPLVGREIPIIADEYVDPEFGTGAVKITPAHDPNDFEVGKRHNLPMI-NILDEDGT- 301
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 368 pdlseqaLTEKGtlfnsGEFSGLSFEDGFNAIADKLASLG-----------VG--------------------------- 409
Cdd:COG0525 302 -------INENA-----GKYRGLDRFEARKAIVADLEELGllvkvephkhsVGhsdrsgtviepylsdqwfvkmkplakp 369
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 410 --------------ERKVN-YR-----LRDWGVSRQRYWGAPIPMVTLEDGTVMptpedqlpvilpedVVMDGITSPIKA 469
Cdd:COG0525 370 aieavedgeikfvpERWEKtYFhwmenIRDWCISRQLWWGHRIPAWYCPDGEVY--------------VARTEPEACAKA 435
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 470 DPEwakttvngqpAL-RETDTFDT-FmeSSWyyarytcpqyqegmL----------DSDAANYWLPVDIYIGG--Iehai 535
Cdd:COG0525 436 GSV----------NLtQDEDVLDTwF--SSA--------------LwpfstlgwpeKTEDLKYFYPTSVLVTGfdI---- 485
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 536 mhlLYF---RffhklMRDAGMVNSDE-PAKQLLCQGMVladafyyvgangernwvspvdaiveRDEKGRivkakdaeghe 611
Cdd:COG0525 486 ---IFFwvaR-----MIMMGLHFTGEvPFKDVYIHGLV-------------------------RDEQGR----------- 521
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 612 lvytgmsKMSKSKNNGIDPQVMVERYGADTVRLFMMFASPADMTLEWQESGVEGANRFLKRVW---KLVYEHTAQGDAP- 687
Cdd:COG0525 522 -------KMSKSKGNVIDPLDLIDKYGADALRFTLAALASPGRDIKFDEERVEGYRNFANKLWnasRFVLMNLEGFDPGl 594
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 688 ALNVAALT-EDQQALRRdVHKTIAKVTDDIGRRQtFNTAIAAIMELM-NK-------LAKAP--QEGEQDRALMREALLA 756
Cdd:COG0525 595 DPDPEELSlADRWILSR-LNKTIAEVTEALEKYR-FDEAAQALYDFVwNEfcdwyleLAKPRlyGGDEAAKRETRATLVY 672
|
890 900 910 920
....*....|....*....|....*....|....*....|....*.
gi 504643979 757 V----VRMLNPFTPHVSFTLWQEL---KGEGDIDNAPWPVADESAM 795
Cdd:COG0525 673 VleqiLRLLHPFMPFITEEIWQKLpprKEGESIMLAPWPEADEELI 718
|
|
| leuS |
PRK12300 |
leucyl-tRNA synthetase; Reviewed |
48-793 |
6.44e-54 |
|
leucyl-tRNA synthetase; Reviewed
Pssm-ID: 237049 [Multi-domain] Cd Length: 897 Bit Score: 202.02 E-value: 6.44e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 48 LHMGHVRNYTIGDVIARYQRMLGKNVLQPIGWDAFGLPAEGAA--VKNNTAPAPWTY-----------------DNIA-Y 107
Cdd:PRK12300 1 LHVGHGRTYTIGDVIARYKRMRGYNVLFPMAFHVTGTPILGIAerIARGDPETIELYkslygipeeelekfkdpEYIVeY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 108 ----MKNQLKMLGFGYDWSRELATCTPEYyrweQKF----FTELYKKGLVYKKTSAVNWCPNDQTVlaneqvidgccwrc 179
Cdd:PRK12300 81 fseeAKEDMKRIGYSIDWRREFTTTDPEY----SKFiewqFRKLKEKGLIVKGSHPVRYCPNDNNP-------------- 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 180 dtkVErkeipqwfikitayadellnDLDTLDhwpDTVKTMQrnwigrsEGVEITFNVENyDQTLTVYTTRPDTFMGATYL 259
Cdd:PRK12300 143 ---VG--------------------DHDLLD---GEEPEIV-------EYTLIKFEESE-DLILPAATLRPETIFGVTNL 188
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 260 AVaagHP---------------LAQKAAENnpeLAtfiDECRNTKVAEadmatmEKKGVA-TGFYAKHPLTGEAIPVWAA 323
Cdd:PRK12300 189 WV---NPdatyvkaevdgekwiVSKEAAEK---LS---FQDRDVEIIE------EIKGSElIGKKVKNPVTGKEVPILPA 253
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 324 NFVLMEYGTGAVMAVPGHDQRDY--------EFATKYNLPIKAVI--------LAAD---------GSEPDLsEQALTE- 377
Cdd:PRK12300 254 DFVDPDNGTGVVMSVPAHAPYDYvalrdlkkNKELLDVIEPIPLIevegygefPAKEvveklgiksQEDPEL-EEATKEv 332
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 378 ------KGTLF-NSGEFSGLSFEDGFNAIADKLASLGVG-------ERKV------------------------------ 413
Cdd:PRK12300 333 yraefhKGVLKeNTGEYAGKPVREAREKITKDLIEKGIAdimyefsNRPVycrcgtecvvkvvkdqwfidysdpewkela 412
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 414 ------------NYR---------LRDWGVSRQRYWGAPIP------MVTLEDGTVMP--------------TPEDqlpv 452
Cdd:PRK12300 413 hkaldnmeiipeEYRkefentidwLKDRACARRRGLGTRLPwdeewiIESLSDSTIYMayytiahkireygiKPEQ---- 488
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 453 ILPE--DVVMDGITSPikadPEWAKTTVNGQPALREtdtfdtfMESSWyyarytcpqyqegmldsdaaNYWLPVDIYIGG 530
Cdd:PRK12300 489 LTPEffDYVFLGKGDP----EEVSKKTGIPKEILEE-------MREEF--------------------LYWYPVDWRHSG 537
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 531 IEHAIMHLLYFRFFHKLMRDagmvnsdepaKQLLCQGMVLadafyyvgaNGernWVSpvdaiverdekgrivkakdAEGh 610
Cdd:PRK12300 538 KDLIPNHLTFFIFNHVAIFP----------EEKWPRGIVV---------NG---FVL-------------------LEG- 575
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 611 elvytgmSKMSKSKNNGIDPQVMVERYGADTVRLFMMFASPADMTLEWQESGVEGANRFLKRVWKLVYEHTAQGDAPALN 690
Cdd:PRK12300 576 -------KKMSKSKGNVIPLRKAIEEYGADVVRLYLTSSAELLQDADWREKEVESVRRQLERFYELAKELIEIGGEEELR 648
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 691 vaalTEDQQALRRdVHKTIAKVTDDIGRRQTFNTAIAAIMELMNKLAKApQE--GEQDRALMREALLAVVRMLNPFTPHV 768
Cdd:PRK12300 649 ----FIDKWLLSR-LNRIIKETTEAMESFQTRDAVQEAFYELLNDLRWY-LRrvGEANNKVLREVLEIWIRLLAPFTPHL 722
|
890 900
....*....|....*....|....*
gi 504643979 769 SFTLWQELKGEGDIDNAPWPVADES 793
Cdd:PRK12300 723 AEELWHKLGGEGFVSLEKWPEPDES 747
|
|
| Anticodon_Ia_Leu_BEm |
cd07958 |
Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; ... |
658-776 |
2.17e-49 |
|
Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; This domain is found in leucyl tRNA synthetases (LeuRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain. In contrast to other class Ia enzymes, the anticodon is not used as an identity element in LeuRS (with exceptions such as Saccharomyces cerevisiae and some other eukaryotes). No anticodon-binding site can be defined for this family, which includes bacterial and eukaryotic mitochondrial members, as well as LeuRS from the archaeal Halobacteria. LeuRS catalyzes the transfer of leucine to the 3'-end of its tRNA.
Pssm-ID: 153412 [Multi-domain] Cd Length: 117 Bit Score: 169.71 E-value: 2.17e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 658 WQESGVEGANRFLKRVWKLVYEHTAQGDAPAlNVAALTEDQQALRRDVHKTIAKVTDDIGRRQtFNTAIAAIMELMNKLA 737
Cdd:cd07958 1 WSDSGVEGAYRFLNRVWRLVTELAEALAAPA-AAAELSEEDKELRRKLHKTIKKVTEDIERLR-FNTAIAALMELVNALY 78
|
90 100 110
....*....|....*....|....*....|....*....
gi 504643979 738 KAPQEGEQDRALMREALLAVVRMLNPFTPHVSFTLWQEL 776
Cdd:cd07958 79 KYKKKDAQHAAVLREALETLVLLLAPFAPHIAEELWEEL 117
|
|
| IleS |
COG0060 |
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA ... |
4-794 |
1.34e-48 |
|
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439830 [Multi-domain] Cd Length: 931 Bit Score: 186.05 E-value: 1.34e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 4 QYRPEEIESKVQQHWDEKRTFE--VTEDESKEKYYclsmL----PYPSGRLHMGHVRNYTIGDVIARYQRMLGKNVL-QP 76
Cdd:COG0060 15 RANLPKREPEILKFWEENDIYEksREARAGRPKFV----LhdgpPYANGDIHIGHALNKILKDIIVRYKTMRGFDVPyVP 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 77 iGWDAFGLPAEGAAVKNN--TAPAPWTYD--------------NIAYMKNQLKMLGFGYDWSRELATCTPEYYR---WEq 137
Cdd:COG0060 91 -GWDCHGLPIELKVEKELgiKKKDIEKVGiaefrekcreyalkYVDEQREDFKRLGVWGDWDNPYLTMDPEYEEsiwWA- 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 138 kfFTELYKKGLVYKKTSAVNWCPNDQTVLAN-EqvidgccwrcdtkVERKEI--PQWFIKITAYADELLNDLDTLDhwpd 214
Cdd:COG0060 169 --LKKLYEKGLLYKGLKPVPWCPRCGTALAEaE-------------VEYKDVtsPSIYVKFPVKDEKALLLLEDAY---- 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 215 tvktmqrnwigrsegveitfnvenydqtLTVYTT-------------RPDtfmgATYLAVAAGHP----LAQKAAENnpe 277
Cdd:COG0060 230 ----------------------------LVIWTTtpwtlpanlavavHPD----IDYVLVEVTGGerliLAEALVEA--- 274
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 278 latFIDECRN---TKVAEADMATMEkkgvatGFYAKHPLTGE-----AIPVWAANFVLMEYGTGAV-MAvPGHDQRDYEF 348
Cdd:COG0060 275 ---VLKELGIedyEVLATFKGAELE------GLRYEHPFYYVvgydrAHPVILGDYVTTEDGTGIVhTA-PGHGEDDFEV 344
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 349 ATKYNLPIKAVIlaadgsepdlseqalTEKGTLFNS-GEFSGLSFEDGFNAIADKLASLG-------------------- 407
Cdd:COG0060 345 GKKYGLPVLNPV---------------DDDGRFTEEaPLFAGLFVKDANPAIIEDLKERGallarekithsyphcwrckt 409
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 408 ----------------VGER------KVNY-------RL-------RDWGVSRQRYWGAPIPMVTLED-GTVMPTPEdql 450
Cdd:COG0060 410 pliyratpqwfismdkLRDRaleaieKVNWipewgegRFgnmlenrPDWCISRQRYWGVPIPIWVCEDcGELHRTEE--- 486
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 451 pVI--LPEDVVMDGITSPIKAD------PEWAKTTVNGQPALRETDTFDTFMES--SWYyarytcpqyqeGMLDSDAANY 520
Cdd:COG0060 487 -VIgsVAELLEEEGADAWFELDlhrpflDETLKCPKCGGTMRRVPDVLDVWFDSgsMHF-----------AVLENREELH 554
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 521 WlPVDIYIGGI-EHaimhllyfR-FFHKLMRDAGMVNSDEPAKQLLCQGMVLadafyyvgangernwvspvdaiverDEK 598
Cdd:COG0060 555 F-PADFYLEGSdQT--------RgWFYSSLLTSTALFGRAPYKNVLTHGFVL-------------------------DED 600
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 599 GRivkakdaeghelvytgmsKMSKSKNNGIDPQVMVERYGADTVRLFMMFASP-ADMTLEWQesGVEGANRFLKRVWklv 677
Cdd:COG0060 601 GR------------------KMSKSLGNVVDPQEVIDKYGADILRLWVASSDYwGDLRFSDE--ILKEVRDVYRRLR--- 657
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 678 yeHTA----------QGDAPALNVAALTE-DQQALRRdVHKTIAKVTDDIGRRQtFNTAIAAIMELMN--------KLAK 738
Cdd:COG0060 658 --NTYrfllanlddfDPAEDAVPYEDLPElDRWILSR-LNELIKEVTEAYDNYD-FHRAYRALHNFCVedlsnwylDISK 733
|
890 900 910 920 930 940
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 504643979 739 ----APQEGEQDR----ALMREALLAVVRMLNPFTPHVSFTLWQELKGEGD--IDNAPWPVADESA 794
Cdd:COG0060 734 drlyTEAADSLDRraaqTTLYEVLETLVRLLAPILPFTAEEIWQNLPGEAEesVHLADWPEVDEEL 799
|
|
| ValRS_core |
cd00817 |
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) ... |
42-651 |
3.82e-48 |
|
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) catalytic core domain. This enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. ValRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 185677 [Multi-domain] Cd Length: 382 Bit Score: 175.51 E-value: 3.82e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 42 PYPSGRLHMGHVRNYTIGDVIARYQRMLGKNVLQPIGWDAFGLPAEGAAVKNNTAPAP----------------WTYDNI 105
Cdd:cd00817 10 PNVTGSLHMGHALNNTIQDIIARYKRMKGYNVLWPPGTDHAGIATQVVVEKKLGIEGKtrhdlgreeflekcweWKEESG 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 106 AYMKNQLKMLGFGYDWSRELATCTPEYYRWEQKFFTELYKKGLVYKKTSAVNWCPNDQTVLANEQVidgcCWRCDTKVER 185
Cdd:cd00817 90 GKIREQLKRLGASVDWSREYFTMDPGLSRAVQEAFVRLYEKGLIYRDNRLVNWCPKLRTAISDIEV----CSRSGDVIEP 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 186 KEIPQWFIKITAYADELLndldtldhwpDTVKTMQRNWIgrsegveitfnvenydqtltvyttrPDTfMGATYLAvaagh 265
Cdd:cd00817 166 LLKPQWFVKVKDLAKKAL----------EAVKEGDIKFV-------------------------PER-MEKRYEN----- 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 266 plaqkaaennpelatfidecrntkvaeadmatmekkgvatgfyakhpltgeaipvWAANfvlmeygtgavmavpghdqrd 345
Cdd:cd00817 205 -------------------------------------------------------WLEN--------------------- 208
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 346 yefatkynlpikavilaadgsepdlseqaltekgtlfnsgefsglsfedgfnaiadklaslgvgerkvnyrLRDWGVSRQ 425
Cdd:cd00817 209 -----------------------------------------------------------------------IRDWCISRQ 217
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 426 RYWGAPIPMVTLED-GTVMPTPEDQLPVILPEDVVMDGitspiKADPEWAkttvngqpalRETDTFDTFMeSSWYYARYT 504
Cdd:cd00817 218 LWWGHRIPAWYCKDgGHWVVAREEDEAIDKAAPEACVP-----CGGEELK----------QDEDVLDTWF-SSSLWPFST 281
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 505 CPQYQEgmlDSDAANYWlPVDIYIGGieHAImhlLYFRFFHKLMRdaGMVNSDE-PAKQLLCQGMVladafyyvganger 583
Cdd:cd00817 282 LGWPEE---TKDLKKFY-PTSLLVTG--HDI---IFFWVARMIMR--GLKLTGKlPFKEVYLHGLV-------------- 336
|
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 504643979 584 nwvspvdaiveRDEKGRivkakdaeghelvytgmsKMSKSKNNGIDPQVMVERYGADTVRLFMMFASP 651
Cdd:cd00817 337 -----------RDEDGR------------------KMSKSLGNVIDPLDVIDGYGADALRFTLASAAT 375
|
|
| valS |
PRK14900 |
valyl-tRNA synthetase; Provisional |
5-777 |
1.19e-39 |
|
valyl-tRNA synthetase; Provisional
Pssm-ID: 237855 [Multi-domain] Cd Length: 1052 Bit Score: 158.62 E-value: 1.19e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 5 YRPEEIESKVQQHWDEKRTFEVTEDESKEKYYCLsMLPYP--SGRLHMGHVRNYTIGDVIARYQRMLGKNVLQPIGWDAF 82
Cdd:PRK14900 19 YEHREVEARWYPFWQERGYFHGDEHDRTRPPFSI-VLPPPnvTGSLHLGHALTATLQDVLIRWKRMSGFNTLWLPGTDHA 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 83 GLP-----------AEGAAVKNNTAPA------PWTYDNIAYMKNQLKMLGFGYDWSRELATCTPEYYRWEQKFFTELYK 145
Cdd:PRK14900 98 GIAtqmivekelkkTEKKSRHDLGREAflervwAWKEQYGSRIGEQHKALGASLDWQRERFTMDEGLSRAVREVFVRLHE 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 146 KGLVYKKTSAVNWCPNDQTVLAneqvidgccwrcDTKVERKEipqwfikitAYADELlndldtldhwpdtvktmqrnWig 225
Cdd:PRK14900 178 EGLIYREKKLINWCPDCRTALS------------DLEVEHEE---------AHQGEL--------------------W-- 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 226 rsegvEITFNVENYDQTLTVYTTRPDTFMGATYLAVaagHPLAQKAaennpelatfidecrntkvaeadMATMEKKgvat 305
Cdd:PRK14900 215 -----SFAYPLADGSGEIVVATTRPETMLGDTAVAV---HPLDPRY-----------------------MALHGKK---- 259
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 306 gfyAKHPLTGEAIPVWA-ANFVLMEYGTGAVMAVPGHDQRDYEFATKYNLPIKAVI------LAADGS------------ 366
Cdd:PRK14900 260 ---VRHPITGRTFPIVAdAILVDPKFGTGAVKVTPAHDFNDFEVGKRHGLEMITVIgpdgrmTAEAGPlagldrfearke 336
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 367 -EPDLSEQALTEK--------GTLFNSGEFSGLSFEDGFNAIADKLASLG-----------VGERKVNY------RLRDW 420
Cdd:PRK14900 337 vKRLLAEQGLDRGakphvlplGRCQRSATILEPLLSDQWYVRIEPLARPAieaveqgrtrfIPEQWTNTymawmrNIHDW 416
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 421 GVSRQRYWGAPIPMVTLEDGTVMPTPEDqlpvilpedvvmdgitspikadPEwAKTTVNGQPALRETDTFDTFMESS-WY 499
Cdd:PRK14900 417 CISRQLWWGHQIPAWYCPDGHVTVARET----------------------PE-ACSTCGKAELRQDEDVLDTWFSSGlWP 473
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 500 YARYTCPQyqegmlDSDAANYWLPVDIYIGGiehaimHLLYFRFFHKLMRDAGMVNSDEPAKQLLCQGMVladafyyvga 579
Cdd:PRK14900 474 FSTMGWPE------QTDTLRTFYPTSVMETG------HDIIFFWVARMMMMGLHFMGEVPFRTVYLHPMV---------- 531
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 580 ngernwvspvdaiveRDEKGRivkakdaeghelvytgmsKMSKSKNNGIDPQVMVERYGADTVRLFMMFASPADMTLEWQ 659
Cdd:PRK14900 532 ---------------RDEKGQ------------------KMSKTKGNVIDPLVITEQYGADALRFTLAALTAQGRDIKLA 578
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 660 ESGVEGANRFLKRVWKL-------VYEHTAQGDAPAlnVAALTEDQQ----ALRRDVHKTIAKVtDDIGRRQTFNTAIAA 728
Cdd:PRK14900 579 KERIEGYRAFANKLWNAsrfalmnLSGYQERGEDPA--RLARTPADRwilaRLQRAVNETVEAL-EAFRFNDAANAVYAF 655
|
810 820 830 840 850
....*....|....*....|....*....|....*....|....*....|....*....
gi 504643979 729 IM-ELMN---KLAKA------PQEGEQDRALMREALLAVVRMLNPFTPHVSFTLWQELK 777
Cdd:PRK14900 656 VWhELCDwyiELAKEalasedPEARRSVQAVLVHCLQTSYRLLHPFMPFITEELWHVLR 714
|
|
| PTZ00419 |
PTZ00419 |
valyl-tRNA synthetase-like protein; Provisional |
1-449 |
3.90e-34 |
|
valyl-tRNA synthetase-like protein; Provisional
Pssm-ID: 240411 [Multi-domain] Cd Length: 995 Bit Score: 141.30 E-value: 3.90e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 1 MQEQYRPEEIESKVQQHWDEKRTFEVTEDE----SKEKYYCLSMLPYPSGRLHMGHVRNYTIGDVIARYQRMLGKNVLQP 76
Cdd:PTZ00419 24 MAASYDPKEVESGWYEWWEKSGFFKPAEDAkslnSGKKFVIVLPPPNVTGYLHIGHALTGAIQDSLIRYHRMKGDETLWV 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 77 IGWDAFGLpAEGAAV------KNNtaPAPWTYDNIAYMK--------------NQLKMLGFGYDWSRELATCTPEYYRWE 136
Cdd:PTZ00419 104 PGTDHAGI-ATQVVVekklmkEEN--KTRHDLGREEFLKkvwewkdkhgnnicNQLRRLGSSLDWSREVFTMDEQRSKAV 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 137 QKFFTELYKKGLVYKKTSAVNWCPNDQTVLAneqvidgccwrcDTKVERKEIPQ-WFIKITAYAdellndldtldhwpdt 215
Cdd:PTZ00419 181 KEAFVRLYEDGLIYRDTRLVNWCCYLKTAIS------------DIEVEFEEIEKpTKITIPGYD---------------- 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 216 vKTMQRNWIgrsegVEITFNVENYDQT-LTVYTTRPDTFMGATYLAVaagHPlaqkaaeNNPELATFIdecrntkvaead 294
Cdd:PTZ00419 233 -KKVEVGVL-----WHFAYPLEDSGQEeIVVATTRIETMLGDVAVAV---HP-------KDERYKKLH------------ 284
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 295 matmekkgvatGFYAKHPLT-GEAIPVWA-ANFVLMEYGTGAVMAVPGHDQRDYEFATKYNLPIkAVILAADGSepdlse 372
Cdd:PTZ00419 285 -----------GKELIHPFIpDRKIPIIAdDELVDMEFGTGAVKITPAHDPNDYEIAKRHNLPF-INIFTLDGK------ 346
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 373 qaLTEkgtlfNSGEFSGLSFEDGFNAIADKLASLGVGERK----------------VNYRL------------------- 417
Cdd:PTZ00419 347 --INE-----NGGEFAGMHRFDCRRKIEEELKEMGLLRDKvpnpmrlprcsrsgdiVEPMLipqwyvnckdmakraveav 419
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*..
gi 504643979 418 -----------------------RDWGVSRQRYWGAPIP--MVTLEDGTVMPTPEDQ 449
Cdd:PTZ00419 420 rngelkiipsshenvwyhwleniQDWCISRQLWWGHRIPayRVISKGPETDPSDEEP 476
|
|
| Ile_Leu_Val_MetRS_core |
cd00668 |
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic ... |
34-224 |
4.28e-33 |
|
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases. These class I enzymes are all monomers. However, in some species, MetRS functions as a homodimer, as a result of an additional C-terminal domain. These enzymes aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. Enzymes in this subfamily share an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids. MetRS has a significantly shorter insertion, which lacks the editing function.
Pssm-ID: 185674 [Multi-domain] Cd Length: 312 Bit Score: 130.23 E-value: 4.28e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 34 KYYCLSMLPYPSGRLHMGHVRNYTIGDVIARYQRMLGKNVLQPIGWDAFGLPAEGAA-------------VKNNTAPAPW 100
Cdd:cd00668 1 KFYVTTPPPYANGSLHLGHALTHIIADFIARYKRMRGYEVPFLPGWDTHGLPIELKAerkggrkkktiwiEEFREDPKEF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 101 TYDNIAYMKNQLKMLGFGYDWSRELATCTPEYYRWEQKFFTELYKKGLVYKktsavnwcpndqtvlaneqvidgccwrcD 180
Cdd:cd00668 81 VEEMSGEHKEDFRRLGISYDWSDEYITTEPEYSKAVELIFSRLYEKGLIYR----------------------------G 132
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 504643979 181 TKVERKEiPQWFIKITAYADELLNDLDTLDHWPDTVKTMQRNWI 224
Cdd:cd00668 133 THPVRIT-EQWFFDMPKFKEKLLKALRRGKIVPEHVKNRMEAWL 175
|
|
| PLN02843 |
PLN02843 |
isoleucyl-tRNA synthetase |
11-793 |
2.20e-30 |
|
isoleucyl-tRNA synthetase
Pssm-ID: 215452 [Multi-domain] Cd Length: 974 Bit Score: 129.12 E-value: 2.20e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 11 ESKVQQHWDEKRTFE-VTEDESKEKYYCLSMLPYPSGRLHMGHVRNYTIGDVIARYQRMLGKNVLQPIGWDAFGLPAE-- 87
Cdd:PLN02843 9 EPEIQKLWEENQVYKrVSDRNNGESFTLHDGPPYANGDLHIGHALNKILKDFINRYQLLQGKKVHYVPGWDCHGLPIElk 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 88 -----GAAVKNNTAP-------APWTYDNIAYMKNQLKMLGFGYDWSRELATCTPEYYRWEQKFFTELYKKGLVYKKTSA 155
Cdd:PLN02843 89 vlqslDQEARKELTPiklrakaAKFAKKTVDTQRESFKRYGVWGDWENPYLTLDPEYEAAQIEVFGQMFLNGYIYRGRKP 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 156 VNWCPNDQTVLANEQVidgccwrcdtkverkEIPQWFIKITAYADELLNDLdtldhwPDTVKTMQRNWIGrsegveitfn 235
Cdd:PLN02843 169 VHWSPSSRTALAEAEL---------------EYPEGHVSKSIYVAFPVVSP------SETSPEELEEFLP---------- 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 236 venyDQTLTVYTTRPDTfMGA----------TYLAVAAGHPLAQKAAENNPELATFIDECRNTK-----VAEADMATMEK 300
Cdd:PLN02843 218 ----GLSLAIWTTTPWT-MPAnaavavndklQYSVVEVQSFSEDESTSGGNKKKRPGNVLKEQQklfliVATDLVPALEA 292
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 301 K-GV-----AT-------GFYAKHPLTGEAIPVWAA-NFVLMEYGTGAVMAVPGHDQRDYEFATKYNLPI---------- 356
Cdd:PLN02843 293 KwGVklvvlKTfpgsdleGCRYIHPLYNRESPVVIGgDYITTESGTGLVHTAPGHGQEDYITGLKYGLPLlspvddagkf 372
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 357 -----------------KAVILAADGSEPDLSEQAL---------TEKGTLFNSGEFSGLSFEdGFNAIAdkLASLgvge 410
Cdd:PLN02843 373 teeagqfsglsvlgegnAAVVEALDEAGSLLMEEAYghkypydwrTKKPTIFRATEQWFASVE-GFRQAA--LDAI---- 445
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 411 RKVNY-------RLR-------DWGVSRQRYWGAPIPMVTLEDgtvmpTPEdqlpVILPEDVVmDGITSPIK---ADPEW 473
Cdd:PLN02843 446 DKVKWipaqgenRIRamvsgrsDWCISRQRTWGVPIPVFYHVE-----TKE----PLMNEETI-AHVKSIVAqkgSDAWW 515
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 474 AKTTVNGQPA---------LRETDTFDTFMES--SWyyarytcpqyqEGMLDSDAANYWlPVDIYIGGIEHaimHLLYFR 542
Cdd:PLN02843 516 YMDVEDLLPEkyrdkasdyEKGTDTMDVWFDSgsSW-----------AGVLGSREGLSY-PADLYLEGSDQ---HRGWFQ 580
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 543 ffHKLMRDAGmVNSDEPAKQLLCQGMVLadafyyvgangernwvspvdaiverDEKGRivkakdaeghelvytgmsKMSK 622
Cdd:PLN02843 581 --SSLLTSVA-TKGKAPYKSVLTHGFVL-------------------------DEKGF------------------KMSK 614
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 623 SKNNGIDPQVMVE---------RYGADTVRLFMmfaSPADMT--------LEWQESG----VEGANRFLKRV---WK--- 675
Cdd:PLN02843 615 SLGNVVDPRLVIEggknqkqepAYGADVLRLWV---ASVDYTgdvligpqILKQMSDiyrkLRGTLRYLLGNlhdWKpdn 691
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 676 -LVYEhtaqgDAPALnvaalteDQQALRRdVHKTIAKVTDDIGRRQTFN-TAIA---AIMELMNKLAKAPQE----GEQD 746
Cdd:PLN02843 692 aVPYE-----DLPSI-------DKYALFQ-LENVVNEIEESYDNYQFFKiFQILqrfTIVDLSNFYLDVAKDrlyvGGTT 758
|
890 900 910 920 930 940
....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 747 RALMREA-------LLAVVRMLNPFTPHVSFTLWQELKGEGD------IDNAPWPVADES 793
Cdd:PLN02843 759 SFTRRSCqtvlaahLLSLLRAIAPILPHLAEDAWQNLPFQEDgsaaesVFEAGWPTPNEE 818
|
|
| MetRS_core |
cd00814 |
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) ... |
34-224 |
6.70e-29 |
|
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) catalytic core domain. This class I enzyme aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. MetRS, which consists of the core domain and an anti-codon binding domain, functions as a monomer. However, in some species the anti-codon binding domain is followed by an EMAP domain. In this case, MetRS functions as a homodimer. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. As a result of a deletion event, MetRS has a significantly shorter core domain insertion than IleRS, ValRS, and LeuR. Consequently, the MetRS insertion lacks the editing function.
Pssm-ID: 173907 [Multi-domain] Cd Length: 319 Bit Score: 118.02 E-value: 6.70e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 34 KYYCLSMLPYPSGRLHMGHVRNYTIGDVIARYQRMLGKNVLQPIGWDAFGLPAEGAAVKNNTAPAPWTYDNIAYMKNQLK 113
Cdd:cd00814 1 KVLITTALPYVNGVPHLGHLYGTVLADVFARYQRLRGYDVLFVTGTDEHGTKIEQKAEEEGVTPQELCDKYHEIFKDLFK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 114 MLGFGYD-WSRelaTCTPEYYRWEQKFFTELYKKGLVYKKTSAVNWCPNDQTVLAneqvidgccwrcdtkvERKEIPQWF 192
Cdd:cd00814 81 WLNISFDyFIR---TTSPRHKEIVQEFFKKLYENGYIYEGEYEGLYCVSCERFLP----------------EWREEEHYF 141
|
170 180 190
....*....|....*....|....*....|....
gi 504643979 193 IKITAYADELLNDLDTLDH--WPDTVKTMQRNWI 224
Cdd:cd00814 142 FRLSKFQDRLLEWLEKNPDfiWPENARNEVLSWL 175
|
|
| MetG |
COG0143 |
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA ... |
33-224 |
1.47e-28 |
|
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439913 [Multi-domain] Cd Length: 544 Bit Score: 121.37 E-value: 1.47e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 33 EKYYCLSMLPYPSGRLHMGHVRNYTIGDVIARYQRMLGKNVLQPIGWDAFGLPAEGAAVKNNTAPAPWTYDNIAYMKNQL 112
Cdd:COG0143 1 KKFLVTTAIPYANGPPHIGHLYTYIPADILARYQRLRGHDVLFVTGTDEHGTKIELAAEKEGITPQELVDRIHAEFKELF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 113 KMLGFGYD-WSRelaTCTPEYYRWEQKFFTELYKKGLVYKKTSAVNWCPNDQT--------------------------- 164
Cdd:COG0143 81 EKLGISFDnFIR---TTSPEHKELVQEIFQRLYDNGDIYKGEYEGWYCPECERflpdryvegtcpkcgaedaygdqcenc 157
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 504643979 165 --VLANEQVIDGCCWRCDTKVERKEIPQWFIKITAYADELLNDLDTLDHWPDTVKTMQRNWI 224
Cdd:COG0143 158 gaTLEPTELINPRSAISGAPPELREEEHYFFRLSKYQDRLLEWIEENPDIQPEVRNEVLSWL 219
|
|
| tRNA-synt_1g |
pfam09334 |
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases. |
35-231 |
3.27e-28 |
|
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases.
Pssm-ID: 401322 [Multi-domain] Cd Length: 387 Bit Score: 117.78 E-value: 3.27e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 35 YYCLSMLPYPSGRLHMGHVRNYTIGDVIARYQRMLGKNVLQPIGWDAFGLPAEGAAVKNNTAPAPWTYDNIAYMKNQLKM 114
Cdd:pfam09334 1 ILVTTALPYANGPPHLGHLYSYIPADIFARYLRLRGYDVLFVCGTDEHGTPIELKAEKEGITPEELVDRYHEIHREDFKK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 115 LGFGYD-WSRelaTCTPEYYRWEQKFFTELYKKGLVYKKTSAVNWCPNDQTVLANEQVIDGC------------------ 175
Cdd:pfam09334 81 FNISFDdYGR---TTSERHHELVQEFFLKLYENGYIYEKEIEQFYCPSDERFLPDRYVEGTCphcgsedargdqcencgr 157
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 504643979 176 -----------CWRCDTKVERKEIPQWFIKITAYADELLNDLDTLDH-WPDTVKTMQRNWIgrSEGVE 231
Cdd:pfam09334 158 hleptelinpkCVICGTTPEVKETEHYFFDLSKFQDKLREWIEENNPeWPENVKNMVLEWL--KEGLK 223
|
|
| PLN02943 |
PLN02943 |
aminoacyl-tRNA ligase |
11-788 |
2.84e-27 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215509 [Multi-domain] Cd Length: 958 Bit Score: 119.28 E-value: 2.84e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 11 ESKVQQHWDEKRTFEVTEDESKEKYYCLSMLPYPSGRLHMGHVRNYTIGDVIARYQRMLGKNVLQPIGWDAFG------- 83
Cdd:PLN02943 66 EERIYNWWESQGYFKPNFDRGGDPFVIPMPPPNVTGSLHMGHAMFVTLEDIMVRYNRMKGRPTLWIPGTDHAGiatqlvv 145
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 84 ---LPAEGAAVKNNTAPA------PWTYDNIAYMKNQLKMLGFGYDWSRELATCTPEYYRWEQKFFTELYKKGLVYKKTS 154
Cdd:PLN02943 146 ekmLASEGIKRTDLGRDEftkrvwEWKEKYGGTITNQIKRLGASCDWSRERFTLDEQLSRAVVEAFVRLHEKGLIYQGSY 225
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 155 AVNWCPNDQTVLAneqvidgccwrcDTKVErkeipqwfikitaYADEllndldtldhwPDTVKTMQRNWIGRSegveitf 234
Cdd:PLN02943 226 MVNWSPNLQTAVS------------DLEVE-------------YSEE-----------PGTLYYIKYRVAGGS------- 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 235 nvenyDQTLTVYTTRPDTFMGATYLAVaaghplaqkaaenNPElatfiDEcRNTKVaeadmatmekkgvaTGFYAKHPLT 314
Cdd:PLN02943 263 -----EDFLTIATTRPETLFGDVAIAV-------------NPE-----DD-RYSKY--------------IGKMAIVPMT 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 315 -GEAIPVWAANFVLMEYGTGAVMAVPGHDQRDYEFATKYNLPIKAViLAADGS----------------EPDLSEQALTE 377
Cdd:PLN02943 305 yGRHVPIIADRYVDKDFGTGVLKISPGHDHNDYLLARKLGLPILNV-MNKDGTlnevaglywfeareklWSDLEETGLAV 383
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 378 KGTLFN--------SGE-FSGLSFEDGF---NAIADK-LASLGVGERKV---------NYRL---RDWGVSRQRYWGAPI 432
Cdd:PLN02943 384 KKEPHTlrvprsqrGGEvIEPLVSKQWFvtmEPLAEKaLKAVENGELTIiperfekiyNHWLsniKDWCISRQLWWGHRI 463
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 433 PMVTL------EDGTVMPTPEDQLPvilpedvvmdgitspiKADPEWAKTTVNGQpalrETDTFDTFMESS-WYYARYTC 505
Cdd:PLN02943 464 PVWYIvgkdceEDYIVARSAEEALE----------------KAREKYGKDVEIYQ----DPDVLDTWFSSAlWPFSTLGW 523
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 506 PQyqegmLDSDAANYWLPVDIYIGGieHAIMHLLYFRFFHKLMRDAGMVnsdepakqllcqgmvladAFYYVGANGernw 585
Cdd:PLN02943 524 PD-----VSAEDFKKFYPTTVLETG--HDILFFWVARMVMMGIEFTGTV------------------PFSYVYLHG---- 574
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 586 vspvdaiVERDEKGRivkakdaeghelvytgmsKMSKSKNNGIDPQVMVERYGADTVRlFMMFASPADMTLEWQESGVEG 665
Cdd:PLN02943 575 -------LIRDSQGR------------------KMSKTLGNVIDPLDTIKEFGTDALR-FTLALGTAGQDLNLSTERLTS 628
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 666 ANRFLKRVW---KLVYEH-TAQGDAPAL-NVAALTEDQQA-----------LRRDVHKTIAKVTDDIGR-------RQTF 722
Cdd:PLN02943 629 NKAFTNKLWnagKFVLQNlPSQSDTSAWeHILACKFDKEEsllslplpecwVVSKLHELIDSVTTSYDKyffgdvgREIY 708
|
810 820 830 840 850 860 870
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 504643979 723 NTAIAAIMELMNKLAKAP--QEGEQDRALMREALLA-----VVRMLNPFTPHVSFTLWQELKGEGD-IDNAPWP 788
Cdd:PLN02943 709 DFFWSDFADWYIEASKTRlyHSGDNSALSRAQAVLLyvfenILKLLHPFMPFVTEELWQALPYRKEaLIVSPWP 782
|
|
| PRK11893 |
PRK11893 |
methionyl-tRNA synthetase; Reviewed |
33-204 |
1.31e-25 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237012 [Multi-domain] Cd Length: 511 Bit Score: 111.90 E-value: 1.31e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 33 EKYYCLSMLPYPSGRLHMGHVRNYTIGDVIARYQRMLGKNVLQPIGWDAFGLPAEGAAVKNNTAPAPWTYDNIAYMKNQL 112
Cdd:PRK11893 1 KKFYITTPIYYPNGKPHIGHAYTTLAADVLARFKRLRGYDVFFLTGTDEHGQKIQRKAEEAGISPQELADRNSAAFKRLW 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 113 KMLGFGYD-WSRelaTCTPEYYRWEQKFFTELYKKGLVYKKTSAVNWCPNDQTVLANEQVIDG--CCWRCDTKVERKEIP 189
Cdd:PRK11893 81 EALNISYDdFIR---TTDPRHKEAVQEIFQRLLANGDIYLGKYEGWYCVRCEEFYTESELIEDgyRCPPTGAPVEWVEEE 157
|
170
....*....|....*
gi 504643979 190 QWFIKITAYADELLN 204
Cdd:PRK11893 158 SYFFRLSKYQDKLLE 172
|
|
| IleRS_core |
cd00818 |
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases ... |
42-224 |
1.71e-21 |
|
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases (IleRS) catalytic core domain . This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. IleRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173909 [Multi-domain] Cd Length: 338 Bit Score: 96.53 E-value: 1.71e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 42 PYPSGRLHMGHVRNYTIGDVIARYQRMLGKNVLQPIGWDAFGLPAEGAAVKNNTAPAPWTYDNI--------------AY 107
Cdd:cd00818 10 PYANGLPHYGHALNKILKDIINRYKTMQGYYVPRRPGWDCHGLPIELKVEKELGISGKKDIEKMgiaefnakcrefalRY 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 108 ---MKNQLKMLGFGYDWSRELATCTPEYYRWEQKFFTELYKKGLVYKKTSAVNWcPndqtvlaneqVIdgccwrcdtkve 184
Cdd:cd00818 90 vdeQEEQFQRLGVWVDWENPYKTMDPEYMESVWWVFKQLHEKGLLYRGYKVVPW-P----------LI------------ 146
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 504643979 185 RKEIPQWFIKITAYADELLNDLDTLdHW-PDTVKTMQRNWI 224
Cdd:cd00818 147 YRATPQWFIRVTKIKDRLLEANDKV-NWiPEWVKNRFGNWL 186
|
|
| PLN02882 |
PLN02882 |
aminoacyl-tRNA ligase |
7-797 |
8.82e-20 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215477 [Multi-domain] Cd Length: 1159 Bit Score: 95.18 E-value: 8.82e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 7 PEEiESKVQQHWDEKRTFE--VTEDESKEKYYCLSMLPYPSGRLHMGHVRNYTIGDVIARYQRMLGKNVLQPIGWDAFGL 84
Cdd:PLN02882 11 PKQ-EEKILSLWSEIDAFKtqLKRTEGLPEYIFYDGPPFATGLPHYGHILAGTIKDIVTRYQSMTGHHVTRRFGWDCHGL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 85 PAEGAAVKNNtapapwtydNIAYMKNQLKMlGFG-YD---------WSRELATCTPEYYRW----------EQKF----- 139
Cdd:PLN02882 90 PVEYEIDKKL---------GIKRRDDVLKM-GIDkYNeecrsivtrYSKEWEKTVTRTGRWidfendyktmDPKFmesvw 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 140 --FTELYKKGLVYKKTSAVNWCPNDQTVLANEQVidgccwrcdtKVERKEIPQWFIKITAyadELLNDLD--TLDHWPDT 215
Cdd:PLN02882 160 wvFKQLFEKGLVYKGFKVMPYSTACKTPLSNFEA----------GLNYKDVSDPAVMVSF---PIVGDPDnaSFVAWTTT 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 216 VKTMQRNwigrsegVEITFNVE-NYdqtltVYTTRPDTfmGATY---------LAVAAGHPLAQKAAENNPELATFIDec 285
Cdd:PLN02882 227 PWTLPSN-------LALCVNPNfTY-----VKVRNKYT--GKVYivaesrlsaLPTAKPKSKKGSKPENAAEGYEVLA-- 290
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 286 rntKVAEADMATMEKKGVATGFYAkhpLTGEAIPVWAANFVLMEYGTGAVMAVPGHDQRDYEFATKYNLPIKAVILA--- 362
Cdd:PLN02882 291 ---KVPGSSLVGKKYEPLFDYFSE---FSDTAFRVVADDYVTDDSGTGVVHCAPAFGEDDYRVCLANGIIEKGGNLPvpv 364
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 363 -ADG----------------SEPDLSEqALTEKGTLFNSGEFSG---LSFEDGFNAIADKLASLGVGERKVNYRL----- 417
Cdd:PLN02882 365 dDDGcftekvtdfsgryvkdADKDIIA-AIKAKGRLVKSGSITHsypFCWRSDTPLIYRAVPSWFVKVEEIKDRLlennk 443
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 418 ---------------------RDWGVSRQRYWGAPIPMVTLEDGT---VMPTPE--DQLPVILPEDV---VMDGITSPIK 468
Cdd:PLN02882 444 qtywvpdyvkekrfhnwlenaRDWAVSRSRFWGTPLPIWISDDGEevvVIGSIAelEKLSGVKVTDLhrhFIDHITIPSS 523
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 469 ADPEwakttvngQPALRET-DTFDTFMES-SWYYARYTCPQYQEGMLDSDaanywLPVDIYIGGIEHAimhllyfR-FFH 545
Cdd:PLN02882 524 RGPE--------FGVLRRVdDVFDCWFESgSMPYAYIHYPFENKELFEKN-----FPADFVAEGLDQT-------RgWFY 583
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 546 KLmrdagMVNS----DEPA-KQLLCQGMVLAdafyyvgangernwvspvdaiverdEKGRivkakdaeghelvytgmsKM 620
Cdd:PLN02882 584 TL-----MVLStalfDKPAfKNLICNGLVLA-------------------------EDGK------------------KM 615
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 621 SKSKNNGIDPQVMVERYGADTVRLFMMfASP---ADmTLEWQESGVEG-----------ANRFL----KRVWKLVYEHTA 682
Cdd:PLN02882 616 SKSLKNYPDPNEVIDKYGADALRLYLI-NSPvvrAE-PLRFKEEGVFGvvkdvflpwynAYRFLvqnaKRLEVEGGAPFV 693
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 683 QGDAPALNVAALTEDQ------QALRRDVHKTIA--KVTDDIGRRQTFNTAIAAIMELMNKLAKAPQEGEQD--RAL--M 750
Cdd:PLN02882 694 PLDLAKLQNSANVLDRwinsatQSLVKFVREEMGayRLYTVVPYLVKFIDNLTNIYVRFNRKRLKGRTGEEDcrTALstL 773
|
890 900 910 920 930
....*....|....*....|....*....|....*....|....*....|..
gi 504643979 751 REALLAVVRMLNPFTPHVSFTLWQELKG-----EGDIDNAPWPVADESAMVE 797
Cdd:PLN02882 774 YNVLLTSCKVMAPFTPFFTEVLYQNLRKvlpgsEESIHYCSFPQVDEGELDE 825
|
|
| PLN02381 |
PLN02381 |
valyl-tRNA synthetase |
1-439 |
1.65e-19 |
|
valyl-tRNA synthetase
Pssm-ID: 215214 [Multi-domain] Cd Length: 1066 Bit Score: 94.20 E-value: 1.65e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 1 MQEQYRPEEIESKVQQHWDEKRTFEVTEDESKEKYYCLSMLPYPSGRLHMGHVRNYTIGDVIARYQRMLGKNVLQPIGWD 80
Cdd:PLN02381 96 MAKQYSPSAVEKSWYAWWEKSGYFGADAKSSKPPFVIVLPPPNVTGALHIGHALTAAIEDTIIRWKRMSGYNALWVPGVD 175
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 81 AFGLPAEGAAVKNNTAPAPWTYDNIAYMK-----------------NQLKMLGFGYDWSRELATCTPEYYRWEQKFFTEL 143
Cdd:PLN02381 176 HAGIATQVVVEKKLMRERHLTRHDIGREEfvsevwkwkdeyggtilNQLRRLGASLDWSRECFTMDEQRSKAVTEAFVRL 255
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 144 YKKGLVYKKTSAVNWCPNDQTVLANEQVidgccwrcdTKVERKEipQWFIKITAYAdellndldtldhwpdtvKTMQRnw 223
Cdd:PLN02381 256 YKEGLIYRDIRLVNWDCTLRTAISDVEV---------DYIDIKE--RTLLKVPGYD-----------------KPVEF-- 305
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 224 igrseGVEITFN--VENYDQTLTVYTTRPDTFMGATYLAVaagHPlaqkaaennpelatfiDECRNTKVAeadmatmekk 301
Cdd:PLN02381 306 -----GVLTSFAypLEGGLGEIVVATTRIETMLGDTAIAI---HP----------------DDERYKHLH---------- 351
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 302 gvatGFYAKHPLTGEAIPVWA-ANFVLMEYGTGAVMAVPGHDQRDYEFATKYNLPIkAVILAADGSEPDLS--------- 371
Cdd:PLN02381 352 ----GKFAVHPFNGRKLPIICdAILVDPNFGTGAVKITPAHDPNDFEVGKRHNLEF-INIFTDDGKINSNGgsefagmpr 426
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 372 -------EQALTEKGtLFNSGEFSGLSFedGF----NAIADKL--------------ASLGVGERKVNYRL--------- 417
Cdd:PLN02381 427 faareavIEALQKKG-LYRGAKNNEMRL--GLcsrtNDVVEPMikpqwfvncssmakQALDAAIDGENKKLefipkqyla 503
|
490 500 510
....*....|....*....|....*....|...
gi 504643979 418 ---------RDWGVSRQRYWGAPIPM--VTLED 439
Cdd:PLN02381 504 ewkrwleniRDWCISRQLWWGHRIPAwyVTLED 536
|
|
| metG |
PRK00133 |
methionyl-tRNA synthetase; Reviewed |
41-224 |
6.63e-19 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 234655 [Multi-domain] Cd Length: 673 Bit Score: 91.75 E-value: 6.63e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 41 LPYPSGRLHMGHVRNYTIGDVIARYQRMLGKNVLQPIGWDAFGLPAEGAAVKNNTAPApwtyDNIAYMKNQ----LKMLG 116
Cdd:PRK00133 10 LPYANGPIHLGHLVEYIQADIWVRYQRMRGHEVLFVCADDAHGTPIMLKAEKEGITPE----ELIARYHAEhkrdFAGFG 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 117 FGYD-WSRelaTCTPEYYRWEQKFFTELYKKGLVYKKTSAVNWCPNDQTVL-------------ANEQVIDGC--CWR-- 178
Cdd:PRK00133 86 ISFDnYGS---THSEENRELAQEIYLKLKENGYIYEKTIEQLYDPEKGMFLpdrfvkgtcpkcgAEDQYGDNCevCGAty 162
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 504643979 179 ------------CDTKVERKEIPQWFIKITAYADELLNDLDTLDHWPDTVKTMQRNWI 224
Cdd:PRK00133 163 sptelinpksaiSGATPVLKESEHFFFKLPRFEEFLKEWITRSGELQPNVANKMKEWL 220
|
|
| Anticodon_1 |
pfam08264 |
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA ... |
697-823 |
1.59e-18 |
|
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA synthetases. The domain binds to the anticodon of the tRNA ligase.
Pssm-ID: 400523 [Multi-domain] Cd Length: 141 Bit Score: 82.84 E-value: 1.59e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 697 DQQALRRdVHKTIAKVTDDIGRRQtFNTAIAAIMELMN--------KLAKAPQEGEQD----RALMREALLAVVRMLNPF 764
Cdd:pfam08264 1 DRWILSR-LNKLIKEVTEAYENYR-FNTAAQALYEFFWndlsdwylELIKDRLYGEEPdsraQTTLYEVLETLLRLLAPF 78
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 504643979 765 TPHVSFTLWQELKgegdIDNAPWPVADESAMVENTTLV-----VVQVNGKVRGKITVAVDATEE 823
Cdd:pfam08264 79 MPFITEELWQKES----IHLAPWPEDAELEEAELEEAFelrqeIVQAIRKLRSELKIKKSLPLE 138
|
|
| MetG |
COG0143 |
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA ... |
619-790 |
6.26e-16 |
|
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439913 [Multi-domain] Cd Length: 544 Bit Score: 81.70 E-value: 6.26e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 619 KMSKSKNNGIDPQVMVERYGADTVRLFMMFASP--ADMTLEWQE------SgvEGANR---FLKRVWKLVYEHTAqGDAP 687
Cdd:COG0143 327 KMSKSRGNVIDPDDLLDRYGPDALRYYLLREVPfgQDGDFSWEDfvarvnS--DLANDlgnLASRTLSMIHKYFD-GKVP 403
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 688 AlnVAALTEDQQALRRDVHKTIAKVTDDIGRRQtFNTAIAAIMEL---MNK---------LAKAPQEGEQDRALMR--EA 753
Cdd:COG0143 404 E--PGELTEADEELLAEAEAALEEVAEAMEAFE-FRKALEEIMALaraANKyidetapwkLAKDEDPERLATVLYTllEA 480
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 504643979 754 LLAVVRMLNPFTPHVSFTLWQELKGEGD---IDNAPWPVA 790
Cdd:COG0143 481 LRILAILLKPFLPETAEKILEQLGLEGDeltWEDAGWPLP 520
|
|
| PRK12267 |
PRK12267 |
methionyl-tRNA synthetase; Reviewed |
30-203 |
2.05e-15 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237028 [Multi-domain] Cd Length: 648 Bit Score: 80.61 E-value: 2.05e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 30 ESKEKYYCLSMLPYPSGRLHMGHVrnYT--IGDVIARYQRMLGKNVLQPIGWDAFGLPAEGAAVKNNTAPAPWTyDNIAY 107
Cdd:PRK12267 1 MMKKTFYITTPIYYPNGKPHIGHA--YTtiAADALARYKRLQGYDVFFLTGTDEHGQKIQQAAEKAGKTPQEYV-DEISA 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 108 M-KNQLKMLGFGYDwsRELATCTPEYYRWEQKFFTELYKKGLVYKKTSAVNWCPNDQTVLANEQVIDGC-CWRCDTKVER 185
Cdd:PRK12267 78 GfKELWKKLDISYD--KFIRTTDERHKKVVQKIFEKLYEQGDIYKGEYEGWYCVSCETFFTESQLVDGGkCPDCGREVEL 155
|
170
....*....|....*...
gi 504643979 186 KEIPQWFIKITAYADELL 203
Cdd:PRK12267 156 VKEESYFFRMSKYQDRLL 173
|
|
| PRK12267 |
PRK12267 |
methionyl-tRNA synthetase; Reviewed |
619-776 |
4.77e-13 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237028 [Multi-domain] Cd Length: 648 Bit Score: 72.91 E-value: 4.77e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 619 KMSKSKNNGIDPQVMVERYGADTVRLFMM----FASPADMTlewQESGVE----------G--ANRFLKRVWKlvYEhta 682
Cdd:PRK12267 299 KMSKSKGNVVDPEELVDRYGLDALRYYLLrevpFGSDGDFS---PEALVErinsdlandlGnlLNRTVAMINK--YF--- 370
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 683 QGDAPAlnVAALTEDQQALRRDVHKTIAKVTDDIGRRQtFNTAIAAIMEL---MNK---------LAKapQEGEQDR--A 748
Cdd:PRK12267 371 DGEIPA--PGNVTEFDEELIALAEETLKNYEELMEELQ-FSRALEEVWKLisrANKyidetapwvLAK--DEGKKERlaT 445
|
170 180 190
....*....|....*....|....*....|.
gi 504643979 749 LMR---EALLAVVRMLNPFTPHVSFTLWQEL 776
Cdd:PRK12267 446 VMYhlaESLRKVAVLLSPFMPETSKKIFEQL 476
|
|
| PTZ00427 |
PTZ00427 |
isoleucine-tRNA ligase, putative; Provisional |
9-663 |
5.02e-13 |
|
isoleucine-tRNA ligase, putative; Provisional
Pssm-ID: 173617 [Multi-domain] Cd Length: 1205 Bit Score: 73.46 E-value: 5.02e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 9 EIESKVQQHWDEKRTFEVTEDESKEK--YYCLSMLPYPSGRLHMGHVRNYTIGDVIARYQRMLGKNVLQPIGWDAFGLPA 86
Cdd:PTZ00427 76 EEEEKVLKYWKSIDAFNTSNKLAKNKkaYIFYDGPPFATGLPHYGHLLAGIIKDCVTRYFYQCGFSVERKFGWDCHGLPI 155
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 87 EGAAVKNNtapapwtydNIAYMKNQLKMlgfGYD------------WSRELATCTPEYYRW----------EQKF----- 139
Cdd:PTZ00427 156 EYEIEKEN---------NINKKEDILKM---GIDvynekcrgivlkYSNEWVKTVERIGRWidfkndyktmDKTFmesvw 223
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 140 --FTELYKKGLVYKKTSAVNWCPNDQTVLANEQVidgccwrcdtKVERKEIPQWFIKITAYadeLLNDLDTLDH---WPD 214
Cdd:PTZ00427 224 wvFSELYKNNYVYKSFKVMPYSCKCNTPISNFEL----------NLNYKDTPDPSIIISFV---LCSDFPKVEEecnIEE 290
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 215 TVKTM---------QRNWIGRSEGVEITFNVE-NYDQTLTVYTTRPDTFMGATYLAVAAgHPLAQKAAENNPELATFIDE 284
Cdd:PTZ00427 291 DKQLLgekysvlynNKRENSNNGNNNSTNNVCyAQHSEILAWTTTPWTLPSNLALCVNE-HFTYLRIHHVKSNRVVIVGE 369
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 285 CR-------------NTKVAE----ADMATMEKKGVATGFYAKHPLTGEAIPVWAANFVLMEYGTGAVMAVPGHDQRDYE 347
Cdd:PTZ00427 370 CRlewimkelkwnveDLKIVNrfkgKELKGLRYKPLFTNFYEKYNFKERAYKILADDFVTDDAGTGIVHCAPTYGEDDFR 449
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 348 FATKYNL--PIKAVI---LAADG---SEPDL------------------SEQALTEKGTLFNSGEFSGLS--------FE 393
Cdd:PTZ00427 450 VCKKNGVidPEKNIFidpLDANGyftNEVEEvqnlyikeadnvikkklkNENRLLSNNTIVHSYPFCWRSdtpliyraIP 529
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 394 DGFNAIADKLASL------------GVGERKVNYRL---RDWGVSRQRYWGAPIPMVTLEDgtvMPTpedqlpVILPEDV 458
Cdd:PTZ00427 530 AWFIRVSNSTNELvknnettywipaHIKEKKFHNWIkdaKDWCISRNRYWGTPIPIWADEK---MET------VICVESI 600
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 459 VMDGITSPIKADPEWAKTTVNG----------QPAL-RETDTFDTFMES-SWYYARYTCPQYQEgmlDSDAANYWlPVDI 526
Cdd:PTZ00427 601 KHLEELSGVKNINDLHRHFIDHieiknpkgktYPKLkRIPEVFDCWFESgSMPYAKVHYPFSTE---KEDFHKIF-PADF 676
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 527 YIGGIEHAimhllyFRFFHKLMRDAGMVNSDEPAKQLLCQGMVLADafyyvgangernwvspvdaiverDEKgrivkakd 606
Cdd:PTZ00427 677 IAEGLDQT------RGWFYTLLVISTLLFDKAPFKNLICNGLVLAS-----------------------DGK-------- 719
|
730 740 750 760 770
....*....|....*....|....*....|....*....|....*....|....*....
gi 504643979 607 aeghelvytgmsKMSKSKNNGIDPQVMVERYGADTVRLFMM--FASPADmTLEWQESGV 663
Cdd:PTZ00427 720 ------------KMSKRLKNYPDPLYILDKYGADSLRLYLInsVAVRAE-NLKFQEKGV 765
|
|
| PLN02959 |
PLN02959 |
aminoacyl-tRNA ligase |
9-92 |
8.51e-11 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215518 [Multi-domain] Cd Length: 1084 Bit Score: 65.86 E-value: 8.51e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 9 EIESKVQQHWDEKRTFEV--TEDESK--EKYYCLSMLPYPSGRLHMGHVRNYTIGDVIARYQRMLGKNVLQPIGWDAFGL 84
Cdd:PLN02959 17 EIEVAVQKWWEEEKVFEAeaGDEPPKpgEKFFGNFPYPYMNGLLHLGHAFSLSKLEFAAAYHRLRGANVLLPFAFHCTGM 96
|
....*...
gi 504643979 85 PAEGAAVK 92
Cdd:PLN02959 97 PIKASADK 104
|
|
| CysS |
COG0215 |
Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA ... |
619-762 |
1.36e-09 |
|
Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439985 [Multi-domain] Cd Length: 465 Bit Score: 61.27 E-value: 1.36e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 619 KMSKSKNNGIDPQVMVERYGADTVRLFMMFA---SPadmtLEWQESGVEGANRFLKRVWKLVYEHTAQGDAPalnvAALT 695
Cdd:COG0215 265 KMSKSLGNFFTVRDLLKKYDPEVLRFFLLSAhyrSP----LDFSEEALEEAEKALERLYNALRRLEEALGAA----DSSA 336
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 504643979 696 EDQQALRRDVHKTIAkvtDDigrrqtFNT--AIAAIMELMNKLAKAPQEGEqDRALMREALLAVVRMLN 762
Cdd:COG0215 337 EEIEELREEFIAAMD---DD------FNTpeALAVLFELVREINKALDEGE-DKAALAALAALLRALGG 395
|
|
| PLN02224 |
PLN02224 |
methionine-tRNA ligase |
25-202 |
1.51e-06 |
|
methionine-tRNA ligase
Pssm-ID: 177869 [Multi-domain] Cd Length: 616 Bit Score: 52.02 E-value: 1.51e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 25 EVTEDESkEKYYCLSMLPYPSGRLHMGHVRNYTIGDVIARYQRMLGKNVLQPIGWDAFGLPAEGAAVKNNTAPaPWTYDN 104
Cdd:PLN02224 62 ESTVDEA-DTFVLTTPLYYVNAPPHMGSAYTTIAADSIARFQRLLGKKVIFITGTDEHGEKIATSAAANGRNP-PEHCDI 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 105 IAYMKNQL-KMLGFGYDwsRELATCTPEYYRWEQKFFTELYKKGLVYKKTSAVNWCPNDQTVLANEQVIDGCCwrCDTK- 182
Cdd:PLN02224 140 ISQSYRTLwKDLDIAYD--KFIRTTDPKHEAIVKEFYARVFANGDIYRADYEGLYCVNCEEYKDEKELLENNC--CPVHq 215
|
170 180
....*....|....*....|...
gi 504643979 183 ---VERKEiPQWFIKITAYADEL 202
Cdd:PLN02224 216 mpcVARKE-DNYFFALSKYQKPL 237
|
|
| Anticodon_Ia_Val |
cd07962 |
Anticodon-binding domain of valyl tRNA synthetases; This domain is found in valyl tRNA ... |
660-776 |
5.22e-06 |
|
Anticodon-binding domain of valyl tRNA synthetases; This domain is found in valyl tRNA synthetases (ValRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. ValRS catalyzes the transfer of valine to the 3'-end of its tRNA.
Pssm-ID: 153416 [Multi-domain] Cd Length: 135 Bit Score: 46.78 E-value: 5.22e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 660 ESGVEGANRFLKRVW---KLVYEHTAQGDAPALNVAALTEDQQALRRDVHKTIAKVTDDIGRRQtFNTAIAAI------- 729
Cdd:cd07962 3 EKRVEGGRNFCNKLWnaaRFVLMNLEDDDEPEEDPESLSLADRWILSRLNKTVEEVTEALENYR-FSEAATALyeffwnd 81
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 504643979 730 -----MELMNKLAKAPQEGEQD--RALMREALLAVVRMLNPFTPHVSFTLWQEL 776
Cdd:cd07962 82 fcdwyLELVKPRLYGEDEEEKKaaRATLYYVLETILRLLHPFMPFITEELWQRL 135
|
|
| Anticodon_Ia_Ile_ABEc |
cd07961 |
Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA ... |
752-793 |
9.53e-05 |
|
Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; This domain is found in isoleucyl tRNA synthetases (IleRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. This family includes bacterial, archaeal, and eukaryotic cytoplasmic members. IleRS catalyzes the transfer of isoleucine to the 3'-end of its tRNA.
Pssm-ID: 153415 [Multi-domain] Cd Length: 183 Bit Score: 44.08 E-value: 9.53e-05
10 20 30 40
....*....|....*....|....*....|....*....|....*..
gi 504643979 752 EALLAVVRMLNPFTPHVSFTLWQELKGEGDIDN-----APWPVADES 793
Cdd:cd07961 116 EVLLTLSRLMAPFTPFITEEIYQNLRRELGDAPesvhlLDWPEVDES 162
|
|
| Anticodon_Ia_Leu_AEc |
cd07959 |
Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases; This ... |
658-776 |
1.86e-04 |
|
Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases; This domain is found in leucyl tRNA synthetases (LeuRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain. In contrast to other class Ia enzymes, the anticodon is not used as an identity element in LeuRS (with exceptions such as Saccharomyces cerevisiae and some other eukaryotes). No anticodon-binding site can be defined for this family, which includes archaeal and eukaryotic cytoplasmic members. LeuRS catalyzes the transfer of leucine to the 3'-end of its tRNA.
Pssm-ID: 153413 [Multi-domain] Cd Length: 117 Bit Score: 41.81 E-value: 1.86e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 658 WQESGVEGANRFLKRVWKLVYEHTAQGDApalnvaaLTEDQQA---LRRDVHKTIAKVTDDIGRRQTFNTAIAAIMELMN 734
Cdd:cd07959 1 FREEEANSAILRLERFYELAEELIETEGE-------LEELTFIdrwLLSRLNRLIKETTEAYENMQFREALKEGLYELQN 73
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 504643979 735 KLAKAPQ--EGEQDRALMREALLAVVRMLNPFTPHVSFTLWQEL 776
Cdd:cd07959 74 DLDWYRErgGAGMNKDLLRRFIEVWTRLLAPFAPHLAEEIWHEL 117
|
|
| argS |
TIGR00456 |
arginyl-tRNA synthetase; This model recognizes arginyl-tRNA synthetase in every completed ... |
42-74 |
4.49e-04 |
|
arginyl-tRNA synthetase; This model recognizes arginyl-tRNA synthetase in every completed genome to date. An interesting feature of the alignment of all arginyl-tRNA synthetases is a fairly deep split between two families. One family includes archaeal, eukaryotic and organellar, spirochete, E. coli, and Synechocystis sp. The second, sharing a deletion of about 25 residues in the central region relative to the first, includes Bacillus subtilis, Aquifex aeolicus, the Mycoplasmas and Mycobacteria, and the Gram-negative bacterium Helicobacter pylori. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273085 [Multi-domain] Cd Length: 563 Bit Score: 43.87 E-value: 4.49e-04
10 20 30
....*....|....*....|....*....|...
gi 504643979 42 PYPSGRLHMGHVRNYTIGDVIARYQRMLGKNVL 74
Cdd:TIGR00456 121 ANPAGPLHVGHLRNAIIGDSLARILEFLGYDVI 153
|
|
| Anticodon_Ia_like |
cd07375 |
Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; This ... |
660-765 |
5.46e-04 |
|
Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; This domain is found in a variety of class Ia aminoacyl tRNA synthetases, C-terminal to the catalytic core domain. It recognizes and specifically binds to the anticodon of the tRNA. Aminoacyl tRNA synthetases catalyze the transfer of cognate amino acids to the 3'-end of their tRNAs by specifically recognizing cognate from non-cognate amino acids. Members include valyl-, leucyl-, isoleucyl-, cysteinyl-, arginyl-, and methionyl-tRNA synthethases. This superfamily also includes a domain from MshC, an enzyme in the mycothiol biosynthetic pathway.
Pssm-ID: 153408 [Multi-domain] Cd Length: 117 Bit Score: 40.57 E-value: 5.46e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 660 ESGVEGANRFLKRVWKLVYE--HTAQGDAPALNVAALTEDQQALRRDVHKTIAKVTDDIgRRQTFNTAIAAIMELMNKL- 736
Cdd:cd07375 1 EERLKQARAFLNRLYRLLSFfrKALGGTQPKWDNELLEEADRELLARLQEFIKRTTNAL-EALDPTTAVQELFKFTNELn 79
|
90 100 110
....*....|....*....|....*....|....*...
gi 504643979 737 ---------AKAPQEGEQDRALMREALLAVVRMLNPFT 765
Cdd:cd07375 80 wyldelkpaLQTEELREAVLAVLRAALVVLTKLLAPFT 117
|
|
| PTZ00399 |
PTZ00399 |
cysteinyl-tRNA-synthetase; Provisional |
619-764 |
5.99e-04 |
|
cysteinyl-tRNA-synthetase; Provisional
Pssm-ID: 240402 [Multi-domain] Cd Length: 651 Bit Score: 43.48 E-value: 5.99e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 619 KMSKSKNNGIDPQVMVERYGADTVR-LFMMfaSPADMTLEWQESGVEGA-------NRFLKRVwklvyeHTAQGDAPALN 690
Cdd:PTZ00399 315 KMSKSLKNFITIRQALSKYTARQIRlLFLL--HKWDKPMNYSDESMDEAiekdkvfFNFFANV------KIKLRESELTS 386
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 504643979 691 VAALTEDQQALRRDVHKTIAKVTDDIgrRQTFNT--AIAAIMELMNKLAKAPQEGEQDRA-LMREALLAVVRMLNPF 764
Cdd:PTZ00399 387 PQKWTQHDFELNELFEETKSAVHAAL--LDNFDTpeALQALQKLISATNTYLNSGEQPSApLLRSVAQYVTKILSIF 461
|
|
| ArgRS_core |
cd00671 |
catalytic core domain of arginyl-tRNA synthetases; Arginyl tRNA synthetase (ArgRS) catalytic ... |
42-74 |
6.72e-04 |
|
catalytic core domain of arginyl-tRNA synthetases; Arginyl tRNA synthetase (ArgRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. There are at least three subgroups of ArgRS. One type contains both characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. The second subtype lacks the KMSKS motif; however, it has a lysine N-terminal to the HIGH motif, which serves as the functional counterpart to the second lysine of the KMSKS motif. A third group, which is found primarily in archaea and a few bacteria, lacks both the KMSKS motif and the HIGH loop lysine.
Pssm-ID: 185675 [Multi-domain] Cd Length: 212 Bit Score: 41.78 E-value: 6.72e-04
10 20 30
....*....|....*....|....*....|...
gi 504643979 42 PYPSGRLHMGHVRNYTIGDVIARYQRMLGKNVL 74
Cdd:cd00671 9 ANPTGPLHVGHLRNAIIGDSLARILEFLGYDVT 41
|
|
| Anticodon_Ia_Met |
cd07957 |
Anticodon-binding domain of methionyl tRNA synthetases; This domain is found in methionyl tRNA ... |
690-776 |
9.73e-04 |
|
Anticodon-binding domain of methionyl tRNA synthetases; This domain is found in methionyl tRNA synthetases (MetRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon (CAU). MetRS catalyzes the transfer of methionine to the 3'-end of its tRNA.
Pssm-ID: 153411 [Multi-domain] Cd Length: 129 Bit Score: 40.17 E-value: 9.73e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 690 NVAALTEDQQALRRDVHKTIAKVTDDIGRRQtFNTAIAAIMEL---MNK---------LAKapqegEQDRALMREAL--- 754
Cdd:cd07957 30 EFGGLTEEDEELLEEAEELLEEVAEAMEELE-FRKALEEIMELaraANKyidetapwkLAK-----EEDPERLATVLyvl 103
|
90 100
....*....|....*....|....*.
gi 504643979 755 LAVVR----MLNPFTPHVSFTLWQEL 776
Cdd:cd07957 104 LELLRilaiLLSPFMPETAEKILDQL 129
|
|
| PLN02610 |
PLN02610 |
probable methionyl-tRNA synthetase |
39-175 |
2.14e-03 |
|
probable methionyl-tRNA synthetase
Pssm-ID: 215329 [Multi-domain] Cd Length: 801 Bit Score: 41.69 E-value: 2.14e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 39 SMLPYPSGRLHMGHVrnytIG-----DVIARYQRMLGKNVLQPIGWDAFGLPAEGAAVKNNTAPAPWTYDNIAYMKNQLK 113
Cdd:PLN02610 23 SALPYVNNVPHLGNI----IGcvlsaDVFARYCRLRGYNAIYICGTDEYGTATETKALEENCTPKEICDKYHAIHKEVYD 98
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 504643979 114 MLGFGYD-WSRelaTCTPEYYRWEQKFFTELYKKGLVYKKTSAVNWCPNDQTVLANEQVIDGC 175
Cdd:PLN02610 99 WFDISFDkFGR---TSTPQQTEICQAIFKKLMENNWLSENTMQQLYCDTCQKFLADRLVEGTC 158
|
|
| PLN02959 |
PLN02959 |
aminoacyl-tRNA ligase |
758-792 |
2.97e-03 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215518 [Multi-domain] Cd Length: 1084 Bit Score: 41.21 E-value: 2.97e-03
10 20 30
....*....|....*....|....*....|....*.
gi 504643979 758 VRMLNPFTPHVSFTLWQE-LKGEGDIDNAPWPVADE 792
Cdd:PLN02959 859 TRLITPICPHYAEHVWREiLKKEGFAVTAGWPVAGE 894
|
|
| class_I_aaRS_core |
cd00802 |
catalytic core domain of class I amino acyl-tRNA synthetase; Class I amino acyl-tRNA ... |
42-127 |
6.37e-03 |
|
catalytic core domain of class I amino acyl-tRNA synthetase; Class I amino acyl-tRNA synthetase (aaRS) catalytic core domain. These enzymes are mostly monomers which aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding.
Pssm-ID: 173901 [Multi-domain] Cd Length: 143 Bit Score: 37.84 E-value: 6.37e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504643979 42 PYPSGRLHMGHVRNYTIGDVIARYQRMLGKNVLQPIGWDAFGLPAEGAAVKNNTAPAPWTYDNIAYMKNQLK-MLGFGYD 120
Cdd:cd00802 6 ITPNGYLHIGHLRTIVTFDFLAQAYRKLGYKVRCIALIDDAGGLIGDPANKKGENAKAFVERWIERIKEDVEyMFLQAAD 85
|
....*..
gi 504643979 121 WSRELAT 127
Cdd:cd00802 86 FLLLYET 92
|
|
| |
