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Conserved domains on  [gi|504646559|ref|WP_014833661|]
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MULTISPECIES: lysozyme [Enterobacter]

Protein Classification

lysozyme( domain architecture ID 10091405)

lysozyme, also called endolysin or muramidase, hydrolyzes (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins; similar to Salmonella virus P22 endolysin

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
lyz_endolysin_autolysin cd00737
endolysin and autolysin; The dsDNA phages of eubacteria use endolysins or muralytic enzymes in ...
 8-91 1.08e-23

endolysin and autolysin; The dsDNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell walls. Similarly, bacteria produce autolysins to facilitate the biosynthesis of its cell wall heteropolymer peptidoglycan and cell division. Endolysins and autolysins are found in viruses and bacteria, respectively. Both endolysin and autolysin enzymes cleave the glycosidic beta 1,4-bonds between the N-acetylmuramic acid and the N-acetylglucosamine of the peptidoglycan.


:

Pssm-ID: 381599 [Multi-domain]  Cd Length: 136  Bit Score: 87.96  E-value: 1.08e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504646559   8 AVELIKKQQGLSLEKYRDERGTGVIGYGHVIQQWEKFHRLITVAEAERLLDNDIQIYEMLIQENITQPLTQHQHDALVll 87
Cdd:cd00737    1 GLDLIKEFEGLRLKAYRDPAGVWTIGYGHTGGVVVKPGDTITEAQAEALLRQDLARFEAAVNRLVKVPLNQNQFDALV-- 78


                 ....
gi 504646559  88 MFSF 91
Cdd:cd00737   79 SFAF 82
 
Name Accession Description Interval E-value
lyz_endolysin_autolysin cd00737
endolysin and autolysin; The dsDNA phages of eubacteria use endolysins or muralytic enzymes in ...
 8-91 1.08e-23

endolysin and autolysin; The dsDNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell walls. Similarly, bacteria produce autolysins to facilitate the biosynthesis of its cell wall heteropolymer peptidoglycan and cell division. Endolysins and autolysins are found in viruses and bacteria, respectively. Both endolysin and autolysin enzymes cleave the glycosidic beta 1,4-bonds between the N-acetylmuramic acid and the N-acetylglucosamine of the peptidoglycan.


Pssm-ID: 381599 [Multi-domain]  Cd Length: 136  Bit Score: 87.96  E-value: 1.08e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504646559   8 AVELIKKQQGLSLEKYRDERGTGVIGYGHVIQQWEKFHRLITVAEAERLLDNDIQIYEMLIQENITQPLTQHQHDALVll 87
Cdd:cd00737    1 GLDLIKEFEGLRLKAYRDPAGVWTIGYGHTGGVVVKPGDTITEAQAEALLRQDLARFEAAVNRLVKVPLNQNQFDALV-- 78


                 ....
gi 504646559  88 MFSF 91
Cdd:cd00737   79 SFAF 82
RrrD COG3772
Phage-related lysozyme (muramidase), GH24 family [Cell wall/membrane/envelope biogenesis];
1-93 3.27e-23

Phage-related lysozyme (muramidase), GH24 family [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442986 [Multi-domain]  Cd Length: 146  Bit Score: 86.82  E-value: 3.27e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504646559   1 MLKLSSAAVELIKKQQGLSLEKYRDERGTGVIGYGHVIQQWEKFHRlITVAEAERLLDNDIQIYEMLIQENITQPLTQHQ 80
Cdd:COG3772    1 MMKTSAAGLALIKEFEGFRLKAYRDPAGVWTIGYGHTGKDVKPGDT-ITEEEAEALLAADLAKAEAAVRRLVKVPLTQNQ 79

                         90
                 ....*....|...
gi 504646559  81 HDALVllmfSFSH 93
Cdd:COG3772   80 FDALV----SFAY 88
 
Name Accession Description Interval E-value
lyz_endolysin_autolysin cd00737
endolysin and autolysin; The dsDNA phages of eubacteria use endolysins or muralytic enzymes in ...
 8-91 1.08e-23

endolysin and autolysin; The dsDNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell walls. Similarly, bacteria produce autolysins to facilitate the biosynthesis of its cell wall heteropolymer peptidoglycan and cell division. Endolysins and autolysins are found in viruses and bacteria, respectively. Both endolysin and autolysin enzymes cleave the glycosidic beta 1,4-bonds between the N-acetylmuramic acid and the N-acetylglucosamine of the peptidoglycan.


Pssm-ID: 381599 [Multi-domain]  Cd Length: 136  Bit Score: 87.96  E-value: 1.08e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504646559   8 AVELIKKQQGLSLEKYRDERGTGVIGYGHVIQQWEKFHRLITVAEAERLLDNDIQIYEMLIQENITQPLTQHQHDALVll 87
Cdd:cd00737    1 GLDLIKEFEGLRLKAYRDPAGVWTIGYGHTGGVVVKPGDTITEAQAEALLRQDLARFEAAVNRLVKVPLNQNQFDALV-- 78


                 ....
gi 504646559  88 MFSF 91
Cdd:cd00737   79 SFAF 82
RrrD COG3772
Phage-related lysozyme (muramidase), GH24 family [Cell wall/membrane/envelope biogenesis];
1-93 3.27e-23

Phage-related lysozyme (muramidase), GH24 family [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442986 [Multi-domain]  Cd Length: 146  Bit Score: 86.82  E-value: 3.27e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504646559   1 MLKLSSAAVELIKKQQGLSLEKYRDERGTGVIGYGHVIQQWEKFHRlITVAEAERLLDNDIQIYEMLIQENITQPLTQHQ 80
Cdd:COG3772    1 MMKTSAAGLALIKEFEGFRLKAYRDPAGVWTIGYGHTGKDVKPGDT-ITEEEAEALLAADLAKAEAAVRRLVKVPLTQNQ 79

                         90
                 ....*....|...
gi 504646559  81 HDALVllmfSFSH 93
Cdd:COG3772   80 FDALV----SFAY 88
endolysin_R21-like cd16900
endolysin R21-like proteins; Unlike T4 E phage lysozyme, the endolysin R21 from Enterobacteria ...
 4-107 5.01e-07

endolysin R21-like proteins; Unlike T4 E phage lysozyme, the endolysin R21 from Enterobacteria phage P21 has an N-terminal SAR (signal-arrest-release) domain that anchors the endolysin to the membrane in an inactive form, which act to prevent premature lysis of the infected bacterium. The dsDNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell walls. Similarly, bacteria produce autolysins to facilitate the biosynthesis of its cell wall heteropolymer peptidoglycan and cell division. Endolysins and autolysins are found in viruses and bacteria, respectively. Both endolysin and autolysin enzymes cleave the glycosidic beta 1,4-bonds between the N-acetylmuramic acid and the N-acetylglucosamine of the peptidoglycan.


Pssm-ID: 381619 [Multi-domain]  Cd Length: 142  Bit Score: 44.86  E-value: 5.01e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504646559   4 LSSAAVELIKKQQGLSLEKYRDerGTGV--IGYGH---VIQQWEKFhrliTVAEAERLLDNDIQIYEMLIQENITQPLTQ 78
Cdd:cd16900    4 LALAAAALVGPWEGLRLTAYRD--PVGVwtVCYGHtggDVKPGMRY----TPAECDALLAKDLQEAAAAVDRCVKVPLPD 77

                         90       100
                 ....*....|....*....|....*....
gi 504646559  79 HQHDALVllmfSFSHtpcpiNAIAQAVSR 107
Cdd:cd16900   78 PQRAALA----SFAY-----NVGVGAFCR 97
lyz_P1 cd16901
P1 lysozyme Lyz-like proteins; Enterobacteria phage P1 lysozyme Lyz is secreted to the ...
 4-93 5.57e-06

P1 lysozyme Lyz-like proteins; Enterobacteria phage P1 lysozyme Lyz is secreted to the Escherichia coli periplasm where it is membrane bound and inactive. Activation involves the release from the membrane, an intramolecular thiol-disulfide isomerization and extensive structural rearrangement of the N-terminal region. The dsDNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell walls. Similarly, bacteria produce autolysins to facilitate the biosynthesis of its cell wall heteropolymer peptidoglycan and cell division. Endolysins and autolysins are found in viruses and bacteria, respectively. Both endolysin and autolysin enzymes cleave the glycosidic beta 1,4-bonds between the N-acetylmuramic acid and the N-acetylglucosamine of the peptidoglycan.


Pssm-ID: 381620 [Multi-domain]  Cd Length: 140  Bit Score: 42.21  E-value: 5.57e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504646559   4 LSSAAVELIKKQQGLSLEKYRDERGTGVIGYGH---VIQQwekfhRLITVAEAERLLDNDIQIYEMLIQENI-TQPLTQH 79
Cdd:cd16901    2 TSAAGLELIANAEGCRRDPYKCPAGVPTIGIGSthgVKPG-----DRYTDEQAAKRLAKDIKKAERCVNRCFnGVPLPQG 76

                         90
                 ....*....|....
gi 504646559  80 QHDALVllmfSFSH 93
Cdd:cd16901   77 EFDAYV----SFAF 86
T4-like_lys cd00735
bacteriophage T4-like lysozymes; Bacteriophage T4-like lysozymes hydrolyze the beta-1, ...
 9-78 1.88e-04

bacteriophage T4-like lysozymes; Bacteriophage T4-like lysozymes hydrolyze the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc) in peptidoglycan heteropolymers of prokaryotic cell walls. Members include a variety of bacteriophages (T4, RB49, RB69, Aeh1), as well as Dictyostelium.


Pssm-ID: 381597  Cd Length: 146  Bit Score: 38.12  E-value: 1.88e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 504646559   9 VELIKKQQGLSLEKYRDERGTGVIGYGHVI--QQWEKFHRLITVAEAERLLDNDIQ--IYEMLIQENITQPLTQ 78
Cdd:cd00735    3 REMLRQDEGYRLKAYKDTEGYPTIGIGHLIgkKGASLTNGTITKDEAEALFEQDVDraVRDMLRNPKLAPVYAQ 76
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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