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Conserved domains on  [gi|504659143|ref|WP_014846245|]
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zf-HC2 domain-containing protein [Arachnia propionica]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RsiW COG5662
Transmembrane transcriptional regulator RsiW (anti-sigma-W factor) [Transcription];
5-156 2.78e-11

Transmembrane transcriptional regulator RsiW (anti-sigma-W factor) [Transcription];


:

Pssm-ID: 444381 [Multi-domain]  Cd Length: 155  Bit Score: 61.40  E-value: 2.78e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504659143   5 DCRRYEDDLSGFVDQTLPERRVNQVSEHLVRCPECSAAVDELRRVRSRL-NSCRAAATLPETLAERLQgiagnecdqply 83
Cdd:COG5662    2 TCDDVEELLHAYLDGELSPEERAEVEAHLATCPACAARLAELRRLRAALrAALAPDEPVPARLRARVM------------ 69

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 504659143  84 lagdgpRRHSRGGRLIRGGMAAtvALATLMMLSLALAKEPAVVGDPVRAAR-EQYSLALTTISVGQGVGAVQWA 156
Cdd:COG5662   70 ------ARLPRRRRRRWRAVAA--ADLSAAGFRLVGGRLLPIDGGPDAGHRiTLYVRPASAFRQEGGVNVFYWR 135
RseB super family cl43766
RseB, negative regulator of sigma E activity [Signal transduction mechanisms];
272-393 3.04e-07

RseB, negative regulator of sigma E activity [Signal transduction mechanisms];


The actual alignment was detected with superfamily member COG3026:

Pssm-ID: 442262 [Multi-domain]  Cd Length: 322  Bit Score: 52.22  E-value: 3.04e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504659143 272 VAGRSASVV--EARgDGHlvaRW----WLDDDTGLPLWVERYDTTGRPTLVFGFVSINIGTA------QLATDSTQPYPM 339
Cdd:COG3026  137 VAGRDAQVVrlVPR-DGL---RYgyrlWIDEETGLLLKSDLLDRDGEVLEQFAFTSLELGDPiddsalKPSLAGAKLWRP 212

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 504659143 340 ESVSSANTSgwcvgLPECPLELGGLP----LVA---HASSGEGQNVYQrLVYSDGVRTLSV 393
Cdd:COG3026  213 PLLALPPAD-----AAASGWQLGWLPpgfkLVSqsrRPLPGSGEPVEH-LLYSDGLASVSV 267
 
Name Accession Description Interval E-value
RsiW COG5662
Transmembrane transcriptional regulator RsiW (anti-sigma-W factor) [Transcription];
5-156 2.78e-11

Transmembrane transcriptional regulator RsiW (anti-sigma-W factor) [Transcription];


Pssm-ID: 444381 [Multi-domain]  Cd Length: 155  Bit Score: 61.40  E-value: 2.78e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504659143   5 DCRRYEDDLSGFVDQTLPERRVNQVSEHLVRCPECSAAVDELRRVRSRL-NSCRAAATLPETLAERLQgiagnecdqply 83
Cdd:COG5662    2 TCDDVEELLHAYLDGELSPEERAEVEAHLATCPACAARLAELRRLRAALrAALAPDEPVPARLRARVM------------ 69

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 504659143  84 lagdgpRRHSRGGRLIRGGMAAtvALATLMMLSLALAKEPAVVGDPVRAAR-EQYSLALTTISVGQGVGAVQWA 156
Cdd:COG5662   70 ------ARLPRRRRRRWRAVAA--ADLSAAGFRLVGGRLLPIDGGPDAGHRiTLYVRPASAFRQEGGVNVFYWR 135
RseB COG3026
RseB, negative regulator of sigma E activity [Signal transduction mechanisms];
272-393 3.04e-07

RseB, negative regulator of sigma E activity [Signal transduction mechanisms];


Pssm-ID: 442262 [Multi-domain]  Cd Length: 322  Bit Score: 52.22  E-value: 3.04e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504659143 272 VAGRSASVV--EARgDGHlvaRW----WLDDDTGLPLWVERYDTTGRPTLVFGFVSINIGTA------QLATDSTQPYPM 339
Cdd:COG3026  137 VAGRDAQVVrlVPR-DGL---RYgyrlWIDEETGLLLKSDLLDRDGEVLEQFAFTSLELGDPiddsalKPSLAGAKLWRP 212

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 504659143 340 ESVSSANTSgwcvgLPECPLELGGLP----LVA---HASSGEGQNVYQrLVYSDGVRTLSV 393
Cdd:COG3026  213 PLLALPPAD-----AAASGWQLGWLPpgfkLVSqsrRPLPGSGEPVEH-LLYSDGLASVSV 267
antisig_RsrA TIGR03988
mycothiol system anti-sigma-R factor; Members of this family are the anti-sigma-R factor RsrA, ...
 5-70 1.11e-04

mycothiol system anti-sigma-R factor; Members of this family are the anti-sigma-R factor RsrA, which contains a CXXC motif as a thiol-disulphide redox switch. It interacts with sigma-R. It regulates and is regulated by the mycothiol system, which occurs in many actinomycetes. [Transcription, Transcription factors]


Pssm-ID: 274904  Cd Length: 77  Bit Score: 40.37  E-value: 1.11e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 504659143    5 DCRRYEDDLSGFVDQTLPERRVNQVSEHLVRCPECSAAVDELRRVRSRLNSCRAAATLPETLAERL 70
Cdd:TIGR03988   1 DCSEVLAEVYEYLDGELDDEDCARLRAHLDECPPCLEQYGLEEEVKSLVARCCGGESAPEELRARI 66
zf-HC2 pfam13490
Putative zinc-finger; This is a putative zinc-finger found in some anti-sigma factor proteins.
 6-39 1.46e-04

Putative zinc-finger; This is a putative zinc-finger found in some anti-sigma factor proteins.


Pssm-ID: 463895 [Multi-domain]  Cd Length: 35  Bit Score: 39.07  E-value: 1.46e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 504659143    6 CRRYEDDLSGFVDQTLPERRVNQVSEHLVRCPEC 39
Cdd:pfam13490   1 CEEVRELLSAYLDGELSPEERARVEAHLAGCPAC 34
RseB cd16327
RseB, a sensor in periplasmic stress; This family contains the periplasmic protein RseB (also ...
 272-325 3.55e-04

RseB, a sensor in periplasmic stress; This family contains the periplasmic protein RseB (also known as MucB or Mucb/RseB) which exerts a crucial role in modulating the stability of RseA, the transmembrane anti-sigma-factor that is degraded during sigma-E-dependent transcription caused by bacterial envelope stress. RseB binds to RseA and inhibits its sequential cleavage, thereby functioning as a negative modulator of this response. The protein is composed of two domains, the larger N-terminal domain resembling an unclosed beta-barrel that is remarkably similar structurally to LolA and LolB, proteins capable of binding the lipid anchor of lipoproteins, suggesting that RseA acts as a sensor of periplasmic stress with a dual functionality, detecting mislocalized lipoproteins as well as propagating the signal to induce the sigma-E-response.


Pssm-ID: 319985  Cd Length: 166  Bit Score: 41.01  E-value: 3.55e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 504659143 272 VAGRSASVV--EARGD---GHlvaRWWLDDDTGLPLWVERYDTTGRPTLVFGFVSINIG 325
Cdd:cd16327  111 VAGRPAQVIrlVPKDDlryGY---RLWLDRETGLLLKSDLLDEDGEVLEQFQFTSLEIG 166
 
Name Accession Description Interval E-value
RsiW COG5662
Transmembrane transcriptional regulator RsiW (anti-sigma-W factor) [Transcription];
5-156 2.78e-11

Transmembrane transcriptional regulator RsiW (anti-sigma-W factor) [Transcription];


Pssm-ID: 444381 [Multi-domain]  Cd Length: 155  Bit Score: 61.40  E-value: 2.78e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504659143   5 DCRRYEDDLSGFVDQTLPERRVNQVSEHLVRCPECSAAVDELRRVRSRL-NSCRAAATLPETLAERLQgiagnecdqply 83
Cdd:COG5662    2 TCDDVEELLHAYLDGELSPEERAEVEAHLATCPACAARLAELRRLRAALrAALAPDEPVPARLRARVM------------ 69

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 504659143  84 lagdgpRRHSRGGRLIRGGMAAtvALATLMMLSLALAKEPAVVGDPVRAAR-EQYSLALTTISVGQGVGAVQWA 156
Cdd:COG5662   70 ------ARLPRRRRRRWRAVAA--ADLSAAGFRLVGGRLLPIDGGPDAGHRiTLYVRPASAFRQEGGVNVFYWR 135
RseB COG3026
RseB, negative regulator of sigma E activity [Signal transduction mechanisms];
272-393 3.04e-07

RseB, negative regulator of sigma E activity [Signal transduction mechanisms];


Pssm-ID: 442262 [Multi-domain]  Cd Length: 322  Bit Score: 52.22  E-value: 3.04e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504659143 272 VAGRSASVV--EARgDGHlvaRW----WLDDDTGLPLWVERYDTTGRPTLVFGFVSINIGTA------QLATDSTQPYPM 339
Cdd:COG3026  137 VAGRDAQVVrlVPR-DGL---RYgyrlWIDEETGLLLKSDLLDRDGEVLEQFAFTSLELGDPiddsalKPSLAGAKLWRP 212

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 504659143 340 ESVSSANTSgwcvgLPECPLELGGLP----LVA---HASSGEGQNVYQrLVYSDGVRTLSV 393
Cdd:COG3026  213 PLLALPPAD-----AAASGWQLGWLPpgfkLVSqsrRPLPGSGEPVEH-LLYSDGLASVSV 267
antisig_RsrA TIGR03988
mycothiol system anti-sigma-R factor; Members of this family are the anti-sigma-R factor RsrA, ...
 5-70 1.11e-04

mycothiol system anti-sigma-R factor; Members of this family are the anti-sigma-R factor RsrA, which contains a CXXC motif as a thiol-disulphide redox switch. It interacts with sigma-R. It regulates and is regulated by the mycothiol system, which occurs in many actinomycetes. [Transcription, Transcription factors]


Pssm-ID: 274904  Cd Length: 77  Bit Score: 40.37  E-value: 1.11e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 504659143    5 DCRRYEDDLSGFVDQTLPERRVNQVSEHLVRCPECSAAVDELRRVRSRLNSCRAAATLPETLAERL 70
Cdd:TIGR03988   1 DCSEVLAEVYEYLDGELDDEDCARLRAHLDECPPCLEQYGLEEEVKSLVARCCGGESAPEELRARI 66
zf-HC2 pfam13490
Putative zinc-finger; This is a putative zinc-finger found in some anti-sigma factor proteins.
 6-39 1.46e-04

Putative zinc-finger; This is a putative zinc-finger found in some anti-sigma factor proteins.


Pssm-ID: 463895 [Multi-domain]  Cd Length: 35  Bit Score: 39.07  E-value: 1.46e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 504659143    6 CRRYEDDLSGFVDQTLPERRVNQVSEHLVRCPEC 39
Cdd:pfam13490   1 CEEVRELLSAYLDGELSPEERARVEAHLAGCPAC 34
RseB cd16327
RseB, a sensor in periplasmic stress; This family contains the periplasmic protein RseB (also ...
 272-325 3.55e-04

RseB, a sensor in periplasmic stress; This family contains the periplasmic protein RseB (also known as MucB or Mucb/RseB) which exerts a crucial role in modulating the stability of RseA, the transmembrane anti-sigma-factor that is degraded during sigma-E-dependent transcription caused by bacterial envelope stress. RseB binds to RseA and inhibits its sequential cleavage, thereby functioning as a negative modulator of this response. The protein is composed of two domains, the larger N-terminal domain resembling an unclosed beta-barrel that is remarkably similar structurally to LolA and LolB, proteins capable of binding the lipid anchor of lipoproteins, suggesting that RseA acts as a sensor of periplasmic stress with a dual functionality, detecting mislocalized lipoproteins as well as propagating the signal to induce the sigma-E-response.


Pssm-ID: 319985  Cd Length: 166  Bit Score: 41.01  E-value: 3.55e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 504659143 272 VAGRSASVV--EARGD---GHlvaRWWLDDDTGLPLWVERYDTTGRPTLVFGFVSINIG 325
Cdd:cd16327  111 VAGRPAQVIrlVPKDDlryGY---RLWLDRETGLLLKSDLLDEDGEVLEQFQFTSLEIG 166
RskA COG5343
Anti-sigma-K factor RskA [Signal transduction mechanisms];
22-160 6.49e-04

Anti-sigma-K factor RskA [Signal transduction mechanisms];


Pssm-ID: 444127 [Multi-domain]  Cd Length: 239  Bit Score: 41.16  E-value: 6.49e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504659143  22 PERRvnQVSEHLVRCPECSAAVDELRRVRSRLNSCRAAATLPETLAERLQ---GIAGNECDQPLylagdgpRRHSRGGRL 98
Cdd:COG5343   23 EERR--EFERRLASDPELAAEVAEWEERLAPLADAVEPVAPPPSLWARIEarlDAARAAAAAPA-------ARLWRRLRF 93

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 504659143  99 IRGGMAATVALATLMMLSLALAKEPAVVGDPVRAAREQYSLAlttISVGQGVGAVQWARERG 160
Cdd:COG5343   94 WRGLAAAAAAAALLLAVVLVWLLQPQLNPAPQQVPQLVAVLA---ADDGGPAAVVVVDPSSG 152
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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