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Conserved domains on  [gi|504692254|ref|WP_014879356|]
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alpha/beta hydrolase [Phaeobacter inhibens]

Protein Classification

alpha/beta hydrolase( domain architecture ID 11455169)

alpha/beta hydrolase catalyzes the hydrolysis of substrates with different chemical composition or physicochemical properties using a nucleophile-His-acid catalytic triad

CATH:  3.40.50.1820
EC:  3.-.-.-
Gene Ontology:  GO:0016787
PubMed:  37582413|12369917|19508187

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PldB COG2267
Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];
25-317 1.76e-38

Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];


:

Pssm-ID: 441868 [Multi-domain]  Cd Length: 221  Bit Score: 135.90  E-value: 1.76e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504692254  25 QAHWVTTSDGLRIRVGHWHPDGAEKGTLLLFPGRTEYIEKYGAAAQDLANRGYATLAVDWRGQGLADrllpeRLLGHVVA 104
Cdd:COG2267    4 RLVTLPTRDGLRLRGRRWRPAGSPRGTVVLVHGLGEHSGRYAELAEALAAAGYAVLAFDLRGHGRSD-----GPRGHVDS 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504692254 105 FRDFQKDVDAAVDLAERLAlPKPWFVLGHSMGGAIGLRAVME-GLPVKACVFSAPMWgiqippalrpvarllsamgdrfg 183
Cdd:COG2267   79 FDDYVDDLRAALDALRARP-GLPVVLLGHSMGGLIALLYAARyPDRVAGLVLLAPAY----------------------- 134

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504692254 184 igamrtptttlapyvqaspfegnsltndaemyrlmqdqlAAQPdlsLGGPTVRWLGEsLRECADLAQLpspALPCITFLG 263
Cdd:COG2267  135 ---------------------------------------RADP---LLGPSARWLRA-LRLAEALARI---DVPVLVLHG 168

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 504692254 264 TQEQIVNTAAIHDRMARW-PGGELDLVEDAQHEVMMEgaETRRTIFDKMTRLFDQ 317
Cdd:COG2267  169 GADRVVPPEAARRLAARLsPDVELVLLPGARHELLNE--PAREEVLAAILAWLER 221
 
Name Accession Description Interval E-value
PldB COG2267
Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];
25-317 1.76e-38

Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];


Pssm-ID: 441868 [Multi-domain]  Cd Length: 221  Bit Score: 135.90  E-value: 1.76e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504692254  25 QAHWVTTSDGLRIRVGHWHPDGAEKGTLLLFPGRTEYIEKYGAAAQDLANRGYATLAVDWRGQGLADrllpeRLLGHVVA 104
Cdd:COG2267    4 RLVTLPTRDGLRLRGRRWRPAGSPRGTVVLVHGLGEHSGRYAELAEALAAAGYAVLAFDLRGHGRSD-----GPRGHVDS 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504692254 105 FRDFQKDVDAAVDLAERLAlPKPWFVLGHSMGGAIGLRAVME-GLPVKACVFSAPMWgiqippalrpvarllsamgdrfg 183
Cdd:COG2267   79 FDDYVDDLRAALDALRARP-GLPVVLLGHSMGGLIALLYAARyPDRVAGLVLLAPAY----------------------- 134

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504692254 184 igamrtptttlapyvqaspfegnsltndaemyrlmqdqlAAQPdlsLGGPTVRWLGEsLRECADLAQLpspALPCITFLG 263
Cdd:COG2267  135 ---------------------------------------RADP---LLGPSARWLRA-LRLAEALARI---DVPVLVLHG 168

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 504692254 264 TQEQIVNTAAIHDRMARW-PGGELDLVEDAQHEVMMEgaETRRTIFDKMTRLFDQ 317
Cdd:COG2267  169 GADRVVPPEAARRLAARLsPDVELVLLPGARHELLNE--PAREEVLAAILAWLER 221
Hydrolase_4 pfam12146
Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is ...
 46-299 6.87e-36

Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is approximately 110 amino acids in length. It is found in association with pfam00561. The majority of the members in this family carry the exopeptidase active-site residues of Ser-122, Asp-239 and His-269 as in UniProtKB:Q7ZWC2.


Pssm-ID: 463473 [Multi-domain]  Cd Length: 238  Bit Score: 129.64  E-value: 6.87e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504692254   46 GAEKGTLLLFPGRTEYIEKYGAAAQDLANRGYATLAVDWRGQGLADrllPERllGHVVAFRDFQKDVDAAVDLAERLALP 125
Cdd:pfam12146   1 GEPRAVVVLVHGLGEHSGRYAHLADALAAQGFAVYAYDHRGHGRSD---GKR--GHVPSFDDYVDDLDTFVDKIREEHPG 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504692254  126 KPWFVLGHSMGGAIGLRAVME-GLPVKACVFSAPMWGIQiPPALRPVARLLSAMgdrfgigamrtptttLAPYVQASPFE 204
Cdd:pfam12146  76 LPLFLLGHSMGGLIAALYALRyPDKVDGLILSAPALKIK-PYLAPPILKLLAKL---------------LGKLFPRLRVP 139

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504692254  205 GNSLTNDAEMYRLMQDQLAAQPdLSLGGPTVRWLGESLRECADL-AQLPSPALPCITFLGTQEQIVNTAAIHD--RMARW 281
Cdd:pfam12146 140 NNLLPDSLSRDPEVVAAYAADP-LVHGGISARTLYELLDAGERLlRRAAAITVPLLLLHGGADRVVDPAGSREfyERAGS 218

                         250
                  ....*....|....*...
gi 504692254  282 PGGELDLVEDAQHEVMME 299
Cdd:pfam12146 219 TDKTLKLYPGLYHELLNE 236
PRK10749 PRK10749
lysophospholipase L2; Provisional
 33-318 1.62e-34

lysophospholipase L2; Provisional


Pssm-ID: 182697  Cd Length: 330  Bit Score: 128.19  E-value: 1.62e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504692254  33 DGLRIRVGHWHPDGAEKgTLLLFPGRTEYIEKYGAAAQDLANRGYATLAVDWRGQGLADRLLPERLLGHVVAFRDFqkdV 112
Cdd:PRK10749  39 DDIPIRFVRFRAPHHDR-VVVICPGRIESYVKYAELAYDLFHLGYDVLIIDHRGQGRSGRLLDDPHRGHVERFNDY---V 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504692254 113 DAAVDLAERLALPKPW---FVLGHSMGGAI-GLRAVMEGLPVKACVFSAPMWGIQIPPALRPVARLLS------AMGDRF 182
Cdd:PRK10749 115 DDLAAFWQQEIQPGPYrkrYALAHSMGGAIlTLFLQRHPGVFDAIALCAPMFGIVLPLPSWMARRILNwaeghpRIRDGY 194

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504692254 183 GIGAMRTptttlapyvQASPFEGNSLTNDAEMYRLMQDQLAAQPDLSLGGPTVRWLGESLR--ECAdLAQLPSPALPCIT 260
Cdd:PRK10749 195 AIGTGRW---------RPLPFAINVLTHSRERYRRNLRFYADDPELRVGGPTYHWVRESILagEQV-LAGAGDITTPLLL 264

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 504692254 261 FLGTQEQIVNTAAiHDRM------ARWP--GGELDLVEDAQHEVMMEGAETRRTIFDKMTRLFDQY 318
Cdd:PRK10749 265 LQAEEERVVDNRM-HDRFceartaAGHPceGGKPLVIKGAYHEILFEKDAMRSVALNAIVDFFNRH 329
PST-A TIGR01607
Plasmodium subtelomeric family (PST-A); This model represents a paralogous family of genes in ...
 53-185 1.34e-04

Plasmodium subtelomeric family (PST-A); This model represents a paralogous family of genes in Plasmodium falciparum and Plasmodium yoelii, which are closely related to various phospholipases and lysophospholipases of plants as well as generally being related to the alpha/beta-fold superfamily of hydrolases. These genes are preferentially located in the subtelomeric regions of the chromosomes of both P. falciparum and P. yoelii.


Pssm-ID: 162444 [Multi-domain]  Cd Length: 332  Bit Score: 43.23  E-value: 1.34e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504692254   53 LLFPGRTEYIEKyGAAAQDLANRGYATLAVDWRGQGLADRLlpERLLGHVVAFRDFQKDV-------------------- 112
Cdd:TIGR01607  52 VLIDTDNYYIYK-DSWIENFNKNGYSVYGLDLQGHGESDGL--QNLRGHINCFDDLVYDViqymnrindsiilenetksd 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504692254  113 DAAVDLAERLALPKPWFVLGHSMGGAIGLRA---------VMEGLPVKACVFSAPMWGIQ-----IPPALR----PVARL 174
Cdd:TIGR01607 129 DESYDIVNTKENRLPMYIIGLSMGGNIALRLlellgksneNNDKLNIKGCISLSGMISIKsvgsdDSFKFKyfylPVMNF 208

                         170
                  ....*....|.
gi 504692254  175 LSAMGDRFGIG 185
Cdd:TIGR01607 209 MSRVFPTFRIS 219
 
Name Accession Description Interval E-value
PldB COG2267
Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];
25-317 1.76e-38

Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];


Pssm-ID: 441868 [Multi-domain]  Cd Length: 221  Bit Score: 135.90  E-value: 1.76e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504692254  25 QAHWVTTSDGLRIRVGHWHPDGAEKGTLLLFPGRTEYIEKYGAAAQDLANRGYATLAVDWRGQGLADrllpeRLLGHVVA 104
Cdd:COG2267    4 RLVTLPTRDGLRLRGRRWRPAGSPRGTVVLVHGLGEHSGRYAELAEALAAAGYAVLAFDLRGHGRSD-----GPRGHVDS 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504692254 105 FRDFQKDVDAAVDLAERLAlPKPWFVLGHSMGGAIGLRAVME-GLPVKACVFSAPMWgiqippalrpvarllsamgdrfg 183
Cdd:COG2267   79 FDDYVDDLRAALDALRARP-GLPVVLLGHSMGGLIALLYAARyPDRVAGLVLLAPAY----------------------- 134

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504692254 184 igamrtptttlapyvqaspfegnsltndaemyrlmqdqlAAQPdlsLGGPTVRWLGEsLRECADLAQLpspALPCITFLG 263
Cdd:COG2267  135 ---------------------------------------RADP---LLGPSARWLRA-LRLAEALARI---DVPVLVLHG 168

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 504692254 264 TQEQIVNTAAIHDRMARW-PGGELDLVEDAQHEVMMEgaETRRTIFDKMTRLFDQ 317
Cdd:COG2267  169 GADRVVPPEAARRLAARLsPDVELVLLPGARHELLNE--PAREEVLAAILAWLER 221
Hydrolase_4 pfam12146
Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is ...
 46-299 6.87e-36

Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is approximately 110 amino acids in length. It is found in association with pfam00561. The majority of the members in this family carry the exopeptidase active-site residues of Ser-122, Asp-239 and His-269 as in UniProtKB:Q7ZWC2.


Pssm-ID: 463473 [Multi-domain]  Cd Length: 238  Bit Score: 129.64  E-value: 6.87e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504692254   46 GAEKGTLLLFPGRTEYIEKYGAAAQDLANRGYATLAVDWRGQGLADrllPERllGHVVAFRDFQKDVDAAVDLAERLALP 125
Cdd:pfam12146   1 GEPRAVVVLVHGLGEHSGRYAHLADALAAQGFAVYAYDHRGHGRSD---GKR--GHVPSFDDYVDDLDTFVDKIREEHPG 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504692254  126 KPWFVLGHSMGGAIGLRAVME-GLPVKACVFSAPMWGIQiPPALRPVARLLSAMgdrfgigamrtptttLAPYVQASPFE 204
Cdd:pfam12146  76 LPLFLLGHSMGGLIAALYALRyPDKVDGLILSAPALKIK-PYLAPPILKLLAKL---------------LGKLFPRLRVP 139

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504692254  205 GNSLTNDAEMYRLMQDQLAAQPdLSLGGPTVRWLGESLRECADL-AQLPSPALPCITFLGTQEQIVNTAAIHD--RMARW 281
Cdd:pfam12146 140 NNLLPDSLSRDPEVVAAYAADP-LVHGGISARTLYELLDAGERLlRRAAAITVPLLLLHGGADRVVDPAGSREfyERAGS 218

                         250
                  ....*....|....*...
gi 504692254  282 PGGELDLVEDAQHEVMME 299
Cdd:pfam12146 219 TDKTLKLYPGLYHELLNE 236
PRK10749 PRK10749
lysophospholipase L2; Provisional
 33-318 1.62e-34

lysophospholipase L2; Provisional


Pssm-ID: 182697  Cd Length: 330  Bit Score: 128.19  E-value: 1.62e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504692254  33 DGLRIRVGHWHPDGAEKgTLLLFPGRTEYIEKYGAAAQDLANRGYATLAVDWRGQGLADRLLPERLLGHVVAFRDFqkdV 112
Cdd:PRK10749  39 DDIPIRFVRFRAPHHDR-VVVICPGRIESYVKYAELAYDLFHLGYDVLIIDHRGQGRSGRLLDDPHRGHVERFNDY---V 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504692254 113 DAAVDLAERLALPKPW---FVLGHSMGGAI-GLRAVMEGLPVKACVFSAPMWGIQIPPALRPVARLLS------AMGDRF 182
Cdd:PRK10749 115 DDLAAFWQQEIQPGPYrkrYALAHSMGGAIlTLFLQRHPGVFDAIALCAPMFGIVLPLPSWMARRILNwaeghpRIRDGY 194

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504692254 183 GIGAMRTptttlapyvQASPFEGNSLTNDAEMYRLMQDQLAAQPDLSLGGPTVRWLGESLR--ECAdLAQLPSPALPCIT 260
Cdd:PRK10749 195 AIGTGRW---------RPLPFAINVLTHSRERYRRNLRFYADDPELRVGGPTYHWVRESILagEQV-LAGAGDITTPLLL 264

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 504692254 261 FLGTQEQIVNTAAiHDRM------ARWP--GGELDLVEDAQHEVMMEGAETRRTIFDKMTRLFDQY 318
Cdd:PRK10749 265 LQAEEERVVDNRM-HDRFceartaAGHPceGGKPLVIKGAYHEILFEKDAMRSVALNAIVDFFNRH 329
FrsA COG1073
Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms]; ...
 28-182 1.56e-16

Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms];


Pssm-ID: 440691 [Multi-domain]  Cd Length: 253  Bit Score: 77.65  E-value: 1.56e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504692254  28 WVTTSDGLRIrVGHWH-PDGAEK--GTLLLFPGRTEYIEKYGAAAQDLANRGYATLAVDWRGQGLAD-----RLLPERll 99
Cdd:COG1073   14 TFKSRDGIKL-AGDLYlPAGASKkyPAVVVAHGNGGVKEQRALYAQRLAELGFNVLAFDYRGYGESEgepreEGSPER-- 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504692254 100 ghvvafrdfqKDVDAAVDLAERLAL--PKPWFVLGHSMGGAIGLRAVMEGLPVKACVFSAP--------------MWGIQ 163
Cdd:COG1073   91 ----------RDARAAVDYLRTLPGvdPERIGLLGISLGGGYALNAAATDPRVKAVILDSPftsledlaaqrakeARGAY 160

                        170       180
                 ....*....|....*....|
gi 504692254 164 IPP-ALRPVARLLSAMGDRF 182
Cdd:COG1073  161 LPGvPYLPNVRLASLLNDEF 180
COG4757 COG4757
Predicted alpha/beta hydrolase [General function prediction only];
25-175 5.42e-14

Predicted alpha/beta hydrolase [General function prediction only];


Pssm-ID: 443790 [Multi-domain]  Cd Length: 289  Bit Score: 71.07  E-value: 5.42e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504692254  25 QAHWVTTSDGLRIRVGHWHPDGAEKGTLLLFPG---RTEYiekYGAAAQDLANRGYATLAVDWRGQGLAdrlLPERLLGH 101
Cdd:COG4757    8 ESVTITAADGYPLAARLFPPAGPPRAVVLINPAtgvPQRF---YRPFARYLAERGFAVLTYDYRGIGLS---RPGSLRGF 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504692254 102 VVAFRD-FQKDVDAAVDLAERLALPKPWFVLGHSMGG-AIGLravMEGLP-VKACVF---SAPMWGiQIPPALRPVARLL 175
Cdd:COG4757   82 DAGYRDwGELDLPAVLDALRARFPGLPLLLVGHSLGGqLLGL---APNAErVDRLVTvasGSGYWR-DYPPRRRLKVLLF 157
YvaK COG1647
Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];
69-319 3.98e-13

Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 441253 [Multi-domain]  Cd Length: 246  Bit Score: 68.04  E-value: 3.98e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504692254  69 AQDLANRGYATLAVDWRGQGLAdrllPERLLGhvVAFRDFQKDVDAAVDLAERLAlpKPWFVLGHSMGGAIGLRAVMEGL 148
Cdd:COG1647   35 AEALAKAGYTVYAPRLPGHGTS----PEDLLK--TTWEDWLEDVEEAYEILKAGY--DKVIVIGLSMGGLLALLLAARYP 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504692254 149 PVKACV-FSAPM----WGIQIPPALRPVARLLSAMG------DRFGIGAMRTPTTTLapyvqaspfegnsltndAEMYRL 217
Cdd:COG1647  107 DVAGLVlLSPALkiddPSAPLLPLLKYLARSLRGIGsdiedpEVAEYAYDRTPLRAL-----------------AELQRL 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504692254 218 MQDqlaaqpdlslggptVRwlgeslrecADLAQLPSPALpciTFLGTQEQIVNTAAIHDRMARWPGGELDLV--EDAQHe 295
Cdd:COG1647  170 IRE--------------VR---------RDLPKITAPTL---IIQSRKDEVVPPESARYIYERLGSPDKELVwlEDSGH- 222

                        250       260
                 ....*....|....*....|....
gi 504692254 296 VMMEGAEtRRTIFDKMTRLFDQYA 319
Cdd:COG1647  223 VITLDKD-REEVAEEILDFLERLA 245
Abhydrolase_1 pfam00561
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
 50-301 8.30e-13

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 395444 [Multi-domain]  Cd Length: 245  Bit Score: 67.14  E-value: 8.30e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504692254   50 GTLLLFPGRTEYIEKYGAAAQDLANRGYATLAVDWRGQGLADRLLPErllgHVVAFRDFQKDVDAAVDlaerlALP-KPW 128
Cdd:pfam00561   1 PPVLLLHGLPGSSDLWRKLAPALARDGFRVIALDLRGFGKSSRPKAQ----DDYRTDDLAEDLEYILE-----ALGlEKV 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504692254  129 FVLGHSMGGAIGLRAVMEG-LPVKACVF-SAPMWGIQIPPALRPVARLLSAMGDRFgigAMRTPTTTLAPYVQASPFEGN 206
Cdd:pfam00561  72 NLVGHSMGGLIALAYAAKYpDRVKALVLlGALDPPHELDEADRFILALFPGFFDGF---VADFAPNPLGRLVAKLLALLL 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504692254  207 SLTNDAEMYRLMQDQLAAQ-PDLSLGGPTVRWLG-ESLRECADLAQLPSPALPCITFLGTQEQIVnTAAIHDRMARWPGG 284
Cdd:pfam00561 149 LRLRLLKALPLLNKRFPSGdYALAKSLVTGALLFiETWSTELRAKFLGRLDEPTLIIWGDQDPLV-PPQALEKLAQLFPN 227

                         250
                  ....*....|....*...
gi 504692254  285 ELDLVE-DAQHEVMMEGA 301
Cdd:pfam00561 228 ARLVVIpDAGHFAFLEGP 245
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
28-204 2.59e-11

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 62.34  E-value: 2.59e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504692254  28 WVTTSDGLRIRvGHWH-PDGAEKGTLLLFP--GRTEYIEKYGAAAQDLANRGYATLAVDWRGQGLADRLLPerllghvva 104
Cdd:COG1506    1 TFKSADGTTLP-GWLYlPADGKKYPVVVYVhgGPGSRDDSFLPLAQALASRGYAVLAPDYRGYGESAGDWG--------- 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504692254 105 fRDFQKDVDAAVDLAERLAL--PKPWFVLGHSMGGAIGLRAV-MEGLPVKACVfsapmwgiqippALRPVARLLSAMGD- 180
Cdd:COG1506   71 -GDEVDDVLAAIDYLAARPYvdPDRIGIYGHSYGGYMALLAAaRHPDRFKAAV------------ALAGVSDLRSYYGTt 137

                        170       180
                 ....*....|....*....|....*
gi 504692254 181 -RFGIGAMRTPTTTLAPYVQASPFE 204
Cdd:COG1506  138 rEYTERLMGGPWEDPEAYAARSPLA 162
DLH COG0412
Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism];
29-177 3.42e-10

Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440181 [Multi-domain]  Cd Length: 226  Bit Score: 59.21  E-value: 3.42e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504692254  29 VTTSDGLRIRVGHWHPDGAEK-GTLLLFP---GRTEYIEKYgaaAQDLANRGYATLAVDWRGqGLADRLLPERLLGHVVA 104
Cdd:COG0412    8 IPTPDGVTLPGYLARPAGGGPrPGVVVLHeifGLNPHIRDV---ARRLAAAGYVVLAPDLYG-RGGPGDDPDEARALMGA 83

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 504692254 105 FRDFQ--KDVDAAVDLAERLAL--PKPWFVLGHSMGGAIGLRAVMEGLPVKACVfsaPMWGIQIPPALRPVARLLSA 177
Cdd:COG0412   84 LDPELlaADLRAALDWLKAQPEvdAGRVGVVGFCFGGGLALLAAARGPDLAAAV---SFYGGLPADDLLDLAARIKA 157
YheT COG0429
Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only];
25-159 6.87e-08

Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only];


Pssm-ID: 440198 [Multi-domain]  Cd Length: 323  Bit Score: 53.22  E-value: 6.87e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504692254  25 QAHWVTTSDGLRIRVgHWH-PDGAEKGTLLLFPG-----RTEYIEkygAAAQDLANRGYATLAVDWRGQGLADRLLPeRL 98
Cdd:COG0429   37 RRERLELPDGDFVDL-DWSdPPAPSKPLVVLLHGlegssDSHYAR---GLARALYARGWDVVRLNFRGCGGEPNLLP-RL 111

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 504692254  99 --LGhvvafrDFQkDVDAAVDLAERLALPKPWFVLGHSMGGAIGLRAVME----GLPVKACV-FSAPM 159
Cdd:COG0429  112 yhSG------DTE-DLVWVLAHLRARYPYAPLYAVGFSLGGNLLLKYLGEqgddAPPLKAAVaVSPPL 172
Abhydrolase_6 pfam12697
Alpha/beta hydrolase family; This family contains alpha/beta hydrolase enzymes of diverse ...
 70-306 9.64e-08

Alpha/beta hydrolase family; This family contains alpha/beta hydrolase enzymes of diverse specificity.


Pssm-ID: 463673 [Multi-domain]  Cd Length: 211  Bit Score: 51.71  E-value: 9.64e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504692254   70 QDLANRGYATLAVDWRGQGLADRllperllghvvAFRDFQkDVDAAVDLAERLALPKPWFVLGHSMGGAIGLRAvMEGLP 149
Cdd:pfam12697  15 AALLAAGVAVLAPDLPGHGSSSP-----------PPLDLA-DLADLAALLDELGAARPVVLVGHSLGGAVALAA-AAAAL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504692254  150 VKACVFSAPMWGiqiPPALRPVARLLSAMGDRFGIGAMRTPtttlapyvqasPFEGNSLTNDAEMYRLMQDQLAAQPDLs 229
Cdd:pfam12697  82 VVGVLVAPLAAP---PGLLAALLALLARLGAALAAPAWLAA-----------ESLARGFLDDLPADAEWAAALARLAAL- 146

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 504692254  230 lggptvrWLGESLRECADLAQLPSPALpcitFLGTQEQIVnTAAIHDRMARWPGGELDLVEDAQHEVMMEGAETRRT 306
Cdd:pfam12697 147 -------LAALALLPLAAWRDLPVPVL----VLAEEDRLV-PELAQRLLAALAGARLVVLPGAGHLPLDDPEEVAEA 211
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 31-143 5.28e-07

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 49.61  E-value: 5.28e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504692254  31 TSDGLRIrvgHWHPDGAEKGTLLLFPGRTEYIEKYGAAAQDLAnRGYATLAVDWRGQGLADRLLPERllghvvafrDFQK 110
Cdd:COG0596    8 TVDGVRL---HYREAGPDGPPVVLLHGLPGSSYEWRPLIPALA-AGYRVIAPDLRGHGRSDKPAGGY---------TLDD 74

                         90       100       110
                 ....*....|....*....|....*....|...
gi 504692254 111 DVDAAVDLAERLALpKPWFVLGHSMGGAIGLRA 143
Cdd:COG0596   75 LADDLAALLDALGL-ERVVLVGHSMGGMVALEL 106
PLN02652 PLN02652
hydrolase; alpha/beta fold family protein
 42-197 6.02e-07

hydrolase; alpha/beta fold family protein


Pssm-ID: 215352 [Multi-domain]  Cd Length: 395  Bit Score: 50.66  E-value: 6.02e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504692254  42 WHPDGAE-KGTLLLFPGRTEYIEKYGAAAQDLANRGYATLAVDWRGQGLADRL---LPErlLGHVVAfrdfqkDVDAAVD 117
Cdd:PLN02652 128 WAPAAGEmRGILIIIHGLNEHSGRYLHFAKQLTSCGFGVYAMDWIGHGGSDGLhgyVPS--LDYVVE------DTEAFLE 199

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504692254 118 LAERLALPKPWFVLGHSMGGAIGLRA--------VMEGLpvkacVFSAPmwGIQIPPA---LRPVARLLSAMGDRF---- 182
Cdd:PLN02652 200 KIRSENPGVPCFLFGHSTGGAVVLKAasypsiedKLEGI-----VLTSP--ALRVKPAhpiVGAVAPIFSLVAPRFqfkg 272

                        170
                 ....*....|....*....
gi 504692254 183 ----GIGAMRTPTTTLAPY 197
Cdd:PLN02652 273 ankrGIPVSRDPAALLAKY 291
COG2945 COG2945
Alpha/beta superfamily hydrolase [General function prediction only];
68-173 7.99e-06

Alpha/beta superfamily hydrolase [General function prediction only];


Pssm-ID: 442188 [Multi-domain]  Cd Length: 201  Bit Score: 45.92  E-value: 7.99e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504692254  68 AAQDLANRGYATLAVDWRG----QGLADRLLPERLlghvvafrdfqkDVDAAVDLAERlALPKPWFVLGHSMGGAIGLRA 143
Cdd:COG2945   47 LARALVAAGFAVLRFNFRGvgrsEGEFDEGRGELD------------DAAAALDWLRA-QNPLPLWLAGFSFGAYVALQL 113

                         90       100       110
                 ....*....|....*....|....*....|
gi 504692254 144 VMEGLPVKACVFSAPMWGIQIPPALRPVAR 173
Cdd:COG2945  114 AMRLPEVEGLILVAPPVNRYDFSFLAPCPA 143
COG3571 COG3571
Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only];
67-155 2.83e-05

Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only];


Pssm-ID: 442792 [Multi-domain]  Cd Length: 202  Bit Score: 44.10  E-value: 2.83e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504692254  67 AAAQDLANRGYATLAVD--WR--GQGLADRllPERLLghvVAFRdfqkdvdAAVDLAERLALPKPWFVLGHSMGGAIGLR 142
Cdd:COG3571   29 ALAEALAAAGIAVARFEfpYMvaGRRPPDR--APVLD---AAWR-------AVIAALRARLAGLPLVIGGKSMGGRVASM 96

                         90
                 ....*....|...
gi 504692254 143 AVMEGLPVKACVF 155
Cdd:COG3571   97 LAAEGGGAAGLVC 109
PLN02385 PLN02385
hydrolase; alpha/beta fold family protein
 28-178 1.03e-04

hydrolase; alpha/beta fold family protein


Pssm-ID: 215216 [Multi-domain]  Cd Length: 349  Bit Score: 43.59  E-value: 1.03e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504692254  28 WVTTSDGLRIRVGHWHP-DGAEKGTLLLFPGR----TEYIEkygAAAQDLANRGYATLAVDWRGQGLAdrllpERLLGHV 102
Cdd:PLN02385  65 YEVNSRGVEIFSKSWLPeNSRPKAAVCFCHGYgdtcTFFFE---GIARKIASSGYGVFAMDYPGFGLS-----EGLHGYI 136

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504692254 103 VAFRDFQKDV-DAAVDLAERLALPK-PWFVLGHSMGGAIGLRA-VMEGLPVKACVFSAPMWGIQ---IPPAlrPVARLLS 176
Cdd:PLN02385 137 PSFDDLVDDViEHYSKIKGNPEFRGlPSFLFGQSMGGAVALKVhLKQPNAWDGAILVAPMCKIAddvVPPP--LVLQILI 214


                 ..
gi 504692254 177 AM 178
Cdd:PLN02385 215 LL 216
PST-A TIGR01607
Plasmodium subtelomeric family (PST-A); This model represents a paralogous family of genes in ...
 53-185 1.34e-04

Plasmodium subtelomeric family (PST-A); This model represents a paralogous family of genes in Plasmodium falciparum and Plasmodium yoelii, which are closely related to various phospholipases and lysophospholipases of plants as well as generally being related to the alpha/beta-fold superfamily of hydrolases. These genes are preferentially located in the subtelomeric regions of the chromosomes of both P. falciparum and P. yoelii.


Pssm-ID: 162444 [Multi-domain]  Cd Length: 332  Bit Score: 43.23  E-value: 1.34e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504692254   53 LLFPGRTEYIEKyGAAAQDLANRGYATLAVDWRGQGLADRLlpERLLGHVVAFRDFQKDV-------------------- 112
Cdd:TIGR01607  52 VLIDTDNYYIYK-DSWIENFNKNGYSVYGLDLQGHGESDGL--QNLRGHINCFDDLVYDViqymnrindsiilenetksd 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504692254  113 DAAVDLAERLALPKPWFVLGHSMGGAIGLRA---------VMEGLPVKACVFSAPMWGIQ-----IPPALR----PVARL 174
Cdd:TIGR01607 129 DESYDIVNTKENRLPMYIIGLSMGGNIALRLlellgksneNNDKLNIKGCISLSGMISIKsvgsdDSFKFKyfylPVMNF 208

                         170
                  ....*....|.
gi 504692254  175 LSAMGDRFGIG 185
Cdd:TIGR01607 209 MSRVFPTFRIS 219
PHA02857 PHA02857
monoglyceride lipase; Provisional
 26-141 3.23e-04

monoglyceride lipase; Provisional


Pssm-ID: 165193 [Multi-domain]  Cd Length: 276  Bit Score: 41.80  E-value: 3.23e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504692254  26 AHWVTTSDGLRIRVGHWHPDGAEKGTLLLFPGRTEYIEKYGAAAQDLANRGYATLAVDWRGQGladRLLPERLLghVVAF 105
Cdd:PHA02857   2 ANCMFNLDNDYIYCKYWKPITYPKALVFISHGAGEHSGRYEELAENISSLGILVFSHDHIGHG---RSNGEKMM--IDDF 76

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 504692254 106 RDFQKDVDAAVDLAERLALPKPWFVLGHSMGGAIGL 141
Cdd:PHA02857  77 GVYVRDVVQHVVTIKSTYPGVPVFLLGHSMGATISI 112
COG2936 COG2936
Predicted acyl esterase [General function prediction only];
27-223 9.85e-04

Predicted acyl esterase [General function prediction only];


Pssm-ID: 442179 [Multi-domain]  Cd Length: 555  Bit Score: 40.68  E-value: 9.85e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504692254  27 HWVTTSDGLRIRVGHWHPDGAEK--GTLLLF-P-GRTEYIE-KYGAAAQDLANRGYATLAVDWRGQGLADrllperllGH 101
Cdd:COG2936   15 VWIPMRDGVRLAADIYRPKDAEGpvPVILERtPyGKRDGTAgRDLGPHPYFAERGYAVVVQDVRGTGGSE--------GE 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504692254 102 VVAFR-DFQKDVDAAVD-LAERlalpkPWF-----VLGHSMGGAIGLRAVMEGlpvkacvfsapmwgiqiPPALRPVArL 174
Cdd:COG2936   87 FDPYRvDEQTDGYDTIDwLAKQ-----PWSngkvgMIGISYGGFTQLAAAADR-----------------PPALKAIV-P 143

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 504692254 175 LSAMGDRFGI-----GAMRTPTTTLAPYVQASPFEGNSLTNDAEMYRLMQDQLA 223
Cdd:COG2936  144 QAPTSDRYDDdhyhgGAFLLGFNLGWAATMGAYKERPPDPADARWRELLPDDYA 197
PLN02298 PLN02298
hydrolase, alpha/beta fold family protein
 24-175 3.02e-03

hydrolase, alpha/beta fold family protein


Pssm-ID: 165939 [Multi-domain]  Cd Length: 330  Bit Score: 38.99  E-value: 3.02e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504692254  24 GQAHWVTTSDGLRIRVGHWHPDGAEKGTLLLFpgrteYIEKYG--------AAAQDLANRGYATLAVDWRGQGLADRLlp 95
Cdd:PLN02298  32 GSKSFFTSPRGLSLFTRSWLPSSSSPPRALIF-----MVHGYGndiswtfqSTAIFLAQMGFACFALDLEGHGRSEGL-- 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504692254  96 erllghvvafRDFQKDVDAAV-DLAERLALPK--------PWFVLGHSMGGAIGLRAVMEG-LPVKACVFSAPMWGIQ-- 163
Cdd:PLN02298 105 ----------RAYVPNVDLVVeDCLSFFNSVKqreefqglPRFLYGESMGGAICLLIHLANpEGFDGAVLVAPMCKISdk 174

                        170
                 ....*....|....*...
gi 504692254 164 ------IPPALRPVARLL 175
Cdd:PLN02298 175 irppwpIPQILTFVARFL 192
GrsT COG3208
Surfactin synthase thioesterase subunit [Secondary metabolites biosynthesis, transport and ...
 111-181 3.28e-03

Surfactin synthase thioesterase subunit [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 442441 [Multi-domain]  Cd Length: 237  Bit Score: 38.29  E-value: 3.28e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 504692254 111 DVDAAVD-LAERLA--LPKPWFVLGHSMGGAIG----LRAVMEGLPVKACVF-SApmwgiQIPPALRPVARLLSAMGDR 181
Cdd:COG3208   54 SLEELADdLAEELAplLDRPFALFGHSMGALLAfelaRRLERRGRPLPAHLFvSG-----RRAPHLPRRRRPLHDLSDA 127
Axe1 COG3458
Cephalosporin-C deacetylase or related acetyl esterase [Secondary metabolites biosynthesis, ...
 71-141 7.76e-03

Cephalosporin-C deacetylase or related acetyl esterase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 442681 [Multi-domain]  Cd Length: 318  Bit Score: 37.48  E-value: 7.76e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504692254  71 DLANRGYATLAVDWRGQGLADRLLPE-------RLLGHVVAFRDfQKD--------VDA--AVDLAerLALPkPW----- 128
Cdd:COG3458  103 DWAAAGYAVLVMDTRGQGSSWGDTPDpggysggALPGYMTRGID-DPDtyyyrrvyLDAvrAVDAL--RSLP-EVdgkri 178

                         90
                 ....*....|...
gi 504692254 129 FVLGHSMGGAIGL 141
Cdd:COG3458  179 GVTGGSQGGGLAL 191
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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