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Conserved domains on  [gi|504695107|ref|WP_014882209|]
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MULTISPECIES: quaternary ammonium compound efflux SMR transporter SugE [Enterobacteriaceae]

Protein Classification

DMT family transporter( domain architecture ID 10013801)

DMT (drug/metabolite transporter) family transporter is an inner membrane protein involved in the transport of one or more of a variety of substrates such as amino acids, drugs, metabolites, and sugar phosphates, among others

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK11431 PRK11431
quaternary ammonium compound efflux SMR transporter SugE;
1-105 1.69e-42

quaternary ammonium compound efflux SMR transporter SugE;


:

Pssm-ID: 171110  Cd Length: 105  Bit Score: 134.60  E-value: 1.69e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504695107   1 MSWIILFIAGLLEVVWAIGLKYTHGFTRLTPSVITVSAMIVSIVLLSWAMRSLPVGTAYAVWTGIGAVGAAITGILLLGE 80
Cdd:PRK11431   1 MSWIILVIAGLLEVVWAVGLKYTHGFSRLTPSIITVTAMIVSMALLAWAMKSLPVGTAYAVWTGIGAVGAAITGIVLLGE 80

                         90       100
                 ....*....|....*....|....*
gi 504695107  81 SASLARIASLALIVAGIIGLKLSTH 105
Cdd:PRK11431  81 SASPARLLSLALIVAGIIGLKLSTH 105
 
Name Accession Description Interval E-value
PRK11431 PRK11431
quaternary ammonium compound efflux SMR transporter SugE;
1-105 1.69e-42

quaternary ammonium compound efflux SMR transporter SugE;


Pssm-ID: 171110  Cd Length: 105  Bit Score: 134.60  E-value: 1.69e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504695107   1 MSWIILFIAGLLEVVWAIGLKYTHGFTRLTPSVITVSAMIVSIVLLSWAMRSLPVGTAYAVWTGIGAVGAAITGILLLGE 80
Cdd:PRK11431   1 MSWIILVIAGLLEVVWAVGLKYTHGFSRLTPSIITVTAMIVSMALLAWAMKSLPVGTAYAVWTGIGAVGAAITGIVLLGE 80

                         90       100
                 ....*....|....*....|....*
gi 504695107  81 SASLARIASLALIVAGIIGLKLSTH 105
Cdd:PRK11431  81 SASPARLLSLALIVAGIIGLKLSTH 105
EmrE COG2076
Multidrug transporter EmrE and related cation transporters [Defense mechanisms];
2-105 4.10e-32

Multidrug transporter EmrE and related cation transporters [Defense mechanisms];


Pssm-ID: 441679  Cd Length: 105  Bit Score: 108.26  E-value: 4.10e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504695107   2 SWIILFIAGLLEVVWAIGLKYTHGFTRLTPSVITVSAMIVSIVLLSWAMRSLPVGTAYAVWTGIGAVGAAITGILLLGES 81
Cdd:COG2076    1 AWLYLLLAGLLEVVWTLALKLSDGFTRLLPSVLTVVGYALSFYLLSLALKTLPVGTAYAVWTGIGAVGTALVGILLFGEP 80

                         90       100
                 ....*....|....*....|....
gi 504695107  82 ASLARIASLALIVAGIIGLKLSTH 105
Cdd:COG2076   81 LSLARLLGIALIIAGVVGLKLFSG 104
Multi_Drug_Res pfam00893
Small Multidrug Resistance protein; This family is the Small Multidrug Resistance (SMR) family. ...
 1-93 4.31e-23

Small Multidrug Resistance protein; This family is the Small Multidrug Resistance (SMR) family. Several members have been shown to export a range of toxins, including ethidium bromide and quaternary ammonium compounds, through coupling with proton influx.


Pssm-ID: 459985  Cd Length: 93  Bit Score: 85.03  E-value: 4.31e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504695107    1 MSWIILFIAGLLEVVWAIGLKYTHGFTRLTPSVITVSAMIVSIVLLSWAMRSLPVGTAYAVWTGIGAVGAAITGILLLGE 80
Cdd:pfam00893   1 MGWILLVLAIVLEVVGTSLLKYSEGFTRLWPSILVIVGYGLSFYLLSLALKSIPLGVAYAVWSGIGTVGTTLVGILLFGE 80

                          90
                  ....*....|...
gi 504695107   81 SASLARIASLALI 93
Cdd:pfam00893  81 SLSLKKVIGLGLI 93
 
Name Accession Description Interval E-value
PRK11431 PRK11431
quaternary ammonium compound efflux SMR transporter SugE;
1-105 1.69e-42

quaternary ammonium compound efflux SMR transporter SugE;


Pssm-ID: 171110  Cd Length: 105  Bit Score: 134.60  E-value: 1.69e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504695107   1 MSWIILFIAGLLEVVWAIGLKYTHGFTRLTPSVITVSAMIVSIVLLSWAMRSLPVGTAYAVWTGIGAVGAAITGILLLGE 80
Cdd:PRK11431   1 MSWIILVIAGLLEVVWAVGLKYTHGFSRLTPSIITVTAMIVSMALLAWAMKSLPVGTAYAVWTGIGAVGAAITGIVLLGE 80

                         90       100
                 ....*....|....*....|....*
gi 504695107  81 SASLARIASLALIVAGIIGLKLSTH 105
Cdd:PRK11431  81 SASPARLLSLALIVAGIIGLKLSTH 105
EmrE COG2076
Multidrug transporter EmrE and related cation transporters [Defense mechanisms];
2-105 4.10e-32

Multidrug transporter EmrE and related cation transporters [Defense mechanisms];


Pssm-ID: 441679  Cd Length: 105  Bit Score: 108.26  E-value: 4.10e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504695107   2 SWIILFIAGLLEVVWAIGLKYTHGFTRLTPSVITVSAMIVSIVLLSWAMRSLPVGTAYAVWTGIGAVGAAITGILLLGES 81
Cdd:COG2076    1 AWLYLLLAGLLEVVWTLALKLSDGFTRLLPSVLTVVGYALSFYLLSLALKTLPVGTAYAVWTGIGAVGTALVGILLFGEP 80

                         90       100
                 ....*....|....*....|....
gi 504695107  82 ASLARIASLALIVAGIIGLKLSTH 105
Cdd:COG2076   81 LSLARLLGIALIIAGVVGLKLFSG 104
Multi_Drug_Res pfam00893
Small Multidrug Resistance protein; This family is the Small Multidrug Resistance (SMR) family. ...
 1-93 4.31e-23

Small Multidrug Resistance protein; This family is the Small Multidrug Resistance (SMR) family. Several members have been shown to export a range of toxins, including ethidium bromide and quaternary ammonium compounds, through coupling with proton influx.


Pssm-ID: 459985  Cd Length: 93  Bit Score: 85.03  E-value: 4.31e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504695107    1 MSWIILFIAGLLEVVWAIGLKYTHGFTRLTPSVITVSAMIVSIVLLSWAMRSLPVGTAYAVWTGIGAVGAAITGILLLGE 80
Cdd:pfam00893   1 MGWILLVLAIVLEVVGTSLLKYSEGFTRLWPSILVIVGYGLSFYLLSLALKSIPLGVAYAVWSGIGTVGTTLVGILLFGE 80

                          90
                  ....*....|...
gi 504695107   81 SASLARIASLALI 93
Cdd:pfam00893  81 SLSLKKVIGLGLI 93
emrE PRK09541
EmrE family multidrug efflux SMR transporter;
2-102 7.35e-11

EmrE family multidrug efflux SMR transporter;


Pssm-ID: 137367  Cd Length: 110  Bit Score: 54.20  E-value: 7.35e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504695107   2 SWIILFIAGLLEVVWAIGLKYTHGFTRLTPSVITVSAMIVSIVLLSWAMRSLPVGTAYAVWTGIGAVGAAITGILLLGES 81
Cdd:PRK09541   3 PYIYLGGAILAEVIGTTLMKFSEGFTRLWPSVGTIICYCASFWLLAQTLAYIPTGIAYAIWSGVGIVLISLLSWGFFGQR 82

                         90       100
                 ....*....|....*....|.
gi 504695107  82 ASLARIASLALIVAGIIGLKL 102
Cdd:PRK09541  83 LDLPAIIGMMLICAGVLVINL 103
PRK10452 PRK10452
multidrug/spermidine efflux SMR transporter subunit MdtJ;
3-104 2.59e-07

multidrug/spermidine efflux SMR transporter subunit MdtJ;


Pssm-ID: 182471  Cd Length: 120  Bit Score: 45.15  E-value: 2.59e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504695107   3 WIILFIAGLLEVVWAIGLKYTHGFTRLTPSVITVSAMIVSIVLLSWAMRSLPVGTAYAVWTGIGAVGAAITGILLLGESA 82
Cdd:PRK10452   4 WILLALAIATEITGTLSMKWASVSEGNGGFILMLVMISLSYIFLSFAVKKIALGVAYALWEGIGILFITLFSVLLFDESL 83

                         90       100
                 ....*....|....*....|..
gi 504695107  83 SLARIASLALIVAGIIGLKLST 104
Cdd:PRK10452  84 SLMKIAGLTTLVAGIVLIKSGT 105
PRK10650 PRK10650
multidrug/spermidine efflux SMR transporter subunit MdtI;
6-103 2.72e-06

multidrug/spermidine efflux SMR transporter subunit MdtI;


Pssm-ID: 182618  Cd Length: 109  Bit Score: 42.34  E-value: 2.72e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504695107   6 LFIAGLLEVVWAIGLKYTHGFTRLTPSVITVSAMIVSIVLLSWAMRSLPVGTAYAVWTGIGAVGAAITGILLLGESASLA 85
Cdd:PRK10650  12 LALAIVLEIVANIFLKFSDGFRRKIYGILSLAAVLAAFSALSQAVKGIDLSVAYALWGGFGIAATLAAGWILFGQRLNRK 91

                         90
                 ....*....|....*...
gi 504695107  86 RIASLALIVAGIIGLKLS 103
Cdd:PRK10650  92 GWIGLVLLLAGMVMIKLA 109
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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