|
Name |
Accession |
Description |
Interval |
E-value |
| ampG |
PRK11010 |
muropeptide MFS transporter AmpG; |
1-490 |
0e+00 |
|
muropeptide MFS transporter AmpG;
Pssm-ID: 182898 [Multi-domain] Cd Length: 491 Bit Score: 933.29 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504695669 1 MSSHYLRIFQQPKSAILLILGFASGLPLALTSGTLQAWMTVENIDLKTIGFFSLVGQAYVFKFLWSPVMDRYTPPFLGRR 80
Cdd:PRK11010 1 MSSQYLRIFQQPNSAILLILGFASGLPLALTSGTLQAWMTVENIDLKTIGFFSLVGQAYVFKFLWSPLMDRYTPPFLGRR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504695669 81 RGWLVMTQVLLLLAIAAMGFLEPTTQLRWMAALAVVIAFCSASQDIVFDAWKTDVLPAEERGAGAAISVLGYRLGMLVSG 160
Cdd:PRK11010 81 RGWLLATQLLLLVAIAAMGFLEPGTQLRWLAALAVVIAFCSASQDIVFDAWKTDVLPAEERGAGAAISVLGYRLAMLVSG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504695669 161 GLALWLADRYLGWQGMYWLMAALLIPCIIATIFAPEPSDIIPVPRSLEQAVAEPLRDFFGRNNAWLILLLIVLYKLGDAF 240
Cdd:PRK11010 161 GLALWLADRYLGWQGMYWLMAALLIPCIIATLLAPEPTDTIPVPKTLEQAVVAPLRDFFGRNNAWLILLLIVLYKLGDAF 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504695669 241 AMSLTTTFLIRGVGFDAGEVGVVNKTLGLFATIVGALYGGVLMQRLTLFRALLIFGILQGASNAGYWLLSITDKHMISMA 320
Cdd:PRK11010 241 AMSLTTTFLIRGVGFDAGEVGLVNKTLGLLATIVGALYGGILMQRLSLFRALMIFGILQGVSNAGYWLLSITDKNLYSMG 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504695669 321 AAVFFENLCGGMGTAAFVALLMTLCNKSFSATQFALLSALSAVGRVYVGPIAGWFVEAHGWPTFYLFSVVAAVPGILLLL 400
Cdd:PRK11010 321 AAVFFENLCGGMGTAAFVALLMTLCNKSFSATQFALLSALSAVGRVYVGPVAGWFVEAHGWPTFYLFSVAAAVPGLLLLL 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504695669 401 VCRQTLEYTQRTEHFMPRTEYHTAYRFALRLLMVGCVALALWLVVLIINASTSLALPFEALLLDAG-ALLAIAGILTGGL 479
Cdd:PRK11010 401 VCRQTLEYTQKTDNFIPRTEYPAGYRFALRLLLAGVSLLAVWLLLLTMNALDLTHFSFLPATLLEVgVLVALSGIVLGGL 480
|
490
....*....|.
gi 504695669 480 LDFMALRKTQM 490
Cdd:PRK11010 481 LDYLALRKTHL 491
|
|
| ampG |
PRK11902 |
muropeptide transporter; Reviewed |
15-407 |
0e+00 |
|
muropeptide transporter; Reviewed
Pssm-ID: 183369 [Multi-domain] Cd Length: 402 Bit Score: 531.73 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504695669 15 AILLILGFASGLPLALTSGTLQAWMTVENIDLKTIGFFSLVGQAYVFKFLWSPVMDRYTPPFLGRRRGWLVMTQVLLLLA 94
Cdd:PRK11902 2 GAMLLLGFASGLPLALTSGTLQAWMTVEGLDIQTIGFFSLVGQAYIFKFLWAPLMDRYTPPLLGRRRGWLLLTQVGLAAS 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504695669 95 IAAMGFLEPTTQLRWMAALAVVIAFCSASQDIVFDAWKTDVLPAEERGAGAAISVLGYRLGMLVSGGLALWLADRYLGWQ 174
Cdd:PRK11902 82 IAAMAFCPPHAALWPLAGLAVLVAFLSASQDIVFDAYSTDVLHPEERGAGAAVKVLGYRLAMLVSGGLALWLADRVLGWG 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504695669 175 GMYWLMAALLIPCIIATIFAPEPSDIIPVPRSLEQAVAEPLRDFFGRNNAWLILLLIVLYKLGDAFAMSLTTTFLIRGVG 254
Cdd:PRK11902 162 NTYLLMAGLMLAGALTTLWAPEPEVPARPPRSLGEAVVGPLRDFFSRRGAWALLLLIVLYKLGDAFAGSLSTTFLIRGAG 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504695669 255 FDAGEVGVVNKTLGLFATIVGALYGGVLMQRLTLFRALLIFGILQGASNAGYWLLSITDKHMISMAAAVFFENLCGGMGT 334
Cdd:PRK11902 242 FSAGEVGIVNKTLGLAATIVGALAGGTLMVRLGLYRSLMLFGVLQAVSNLGYWVLAVTPKHLWTMALAIGIENLCGGMGT 321
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 504695669 335 AAFVALLMTLCNKSFSATQFALLSALSAVGRVYVGPIAGWFVEAHGWPTFYLFSVVAAVPGILLLLVCRQTLE 407
Cdd:PRK11902 322 AAFVALLMALCNRSFSATQYALLSALASVGRVYVGPTSGYLVEAYGWPGFYLMTVVIALPGLALLWLMRGTIG 394
|
|
| MFS_AmpG_like |
cd17486 |
AmpG and similar transporters of the Major Facilitator Superfamily; AmpG acts as an inner ... |
17-402 |
9.34e-154 |
|
AmpG and similar transporters of the Major Facilitator Superfamily; AmpG acts as an inner membrane permease in the beta-lactamase induction system and in peptidoglycan recycling. It transports meuropeptide from the periplasm into the cytosol in gram-negative bacteria, which is essential for the induction of the ampC encoding beta-lactamase. The AmpG family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341039 [Multi-domain] Cd Length: 387 Bit Score: 442.81 E-value: 9.34e-154
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504695669 17 LLILGFASGLPLALTSGTLQAWMTVENIDLKTIGFFSLVGQAYVFKFLWSPVMDRYTPPFLGRRRGWLVMTQVLLLLAIA 96
Cdd:cd17486 1 ILLLGFASGLPYLLTGTTLQAWLKEAGVDLDTIGLFSLVGLPYSLKFLWAPLVDRYSTPFLGRRRGWILLTQILLMAALI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504695669 97 AMGFLEPTTQLRWMAALAVVIAFCSASQDIVFDAWKTDVLPAEERGAGAAISVLGYRLGMLVSGGLALWLADrYLGWQGM 176
Cdd:cd17486 81 ALAFLDPFTNLVLSALLFLLVAFFSATQDIAIDAYRIEALEDKEQGAGAGVRVNGYRIGMLVAGAGALYLAD-SLSWSAV 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504695669 177 YWLMAALLIPCIIATIFAPEPSDIIPVPRSLEQAVA---EPLRDFFGRNNAWLILLLIVLYKLGDAFAMSLTTTFLIRGv 253
Cdd:cd17486 160 YLIMAALMGPGILATLFAPEPPRTDPPANSLSETVVaffAPFKDFFGQPGALLILAFILLYKLGDAMLGAMATPFLLDL- 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504695669 254 GFDAGEVGVVNKTLGLFATIVGALYGGVLMQRLTLFRALLIFGILQGASNAGYWLLSITDKHMISMAAAVFFENLCGGMG 333
Cdd:cd17486 239 GFTKTEIGAVYKTVGLIATIVGGLLGGFLMSRLGLKRSLWLFGILQALSNLGFIYLAHAGPNLTLLVAAVAVENFGGGLG 318
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 504695669 334 TAAFVALLMTLCNKSFSATQFALLSALSAVGRVYVGPIAGWFVEAHGWPTFYLFSVVAAVPGILLLLVC 402
Cdd:cd17486 319 TTAFVAYLMSLCNGEFTATQYALLSSLMALGRMVLGAPSGWLAEALGWTGFFLLTTLAAIPGLLLLLKV 387
|
|
| 2A0125 |
TIGR00901 |
AmpG-like permease; [Cellular processes, Adaptations to atypical conditions] |
25-363 |
7.12e-131 |
|
AmpG-like permease; [Cellular processes, Adaptations to atypical conditions]
Pssm-ID: 273329 [Multi-domain] Cd Length: 356 Bit Score: 383.66 E-value: 7.12e-131
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504695669 25 GLPLALTSGTLQAWMTVENIDLKTIGFFSLVGQAYVFKFLWSPVMDRYTPPFLGRRRGWLVMTQVLLLLAIAAMGFLEPT 104
Cdd:TIGR00901 1 GLPLGLVGNTLPYWLRSKNVSLKTIGFFSLVGLPYSLKFLWSPLVDTVYLPFFGRRRSWLVLTQVLLLSLLLILSFLVPS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504695669 105 TQLRWMAALAVVIAFCSASQDIVFDAWKTDVLPAEERGAGAAISVLGYRLGMLVSGGLALWLADRYLG-------WQGMY 177
Cdd:TIGR00901 81 TDLPLLAGLAFLIAFFSATQDIALDAWRLEILSDEELGYGSTIYIVGYRAGMLLSGSLALVLASPEFAntglitlWGYIF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504695669 178 WLMAALLIPCIIATIF-APEPSDIIPVPRSLEQAVAEPLRDFFGRNN---AWLILLLIVLYKLGDAFAMSLTTTFLIRgV 253
Cdd:TIGR00901 161 FWTALLILPGLLVTLFlAKEPQEDASVPKPLTQAVLKPIREFFQRKNmiqALLLLLLIVLYKLGDSAATVLTTLFLLD-M 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504695669 254 GFDAGEVGVVNKTLGLFATIVGALYGGVLMQRLTLFRALLIFGILQGASNAGYWLLS-------ITDKHMISMAAAVFFE 326
Cdd:TIGR00901 240 GFSKEEIALVAKINGLLGAILGGLIGGIIMQPLNILYALLLFGIVQALTNAGFVWLAsnghhdgITFPHLLMLFLTITLE 319
|
330 340 350
....*....|....*....|....*....|....*..
gi 504695669 327 NLCGGMGTAAFVALLMTLCNKSFSATQFALLSALSAV 363
Cdd:TIGR00901 320 AVTGGLGTVAFVAFLSKLSNPKFGATQMALLSSLSAL 356
|
|
| MFS_MFSD3 |
cd17485 |
Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily ... |
16-400 |
1.82e-69 |
|
Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily domain containing 3 protein (MFSD3) is a predicted acetyl-CoA transporter. As an atypical putative membrane-bound solute carrier (SLC), MFSD3 is most likely to be functionally active in the plasma membrane and not in any intracellular organelles. MFSD3 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341038 [Multi-domain] Cd Length: 386 Bit Score: 226.72 E-value: 1.82e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504695669 16 ILLILGFASGLPLALTSGTLQAWMTVENIDLKTIGFFSLVGQAYVFKFLWSPVMDRYTPPFLGRRRGWLVMTQVLLLLAI 95
Cdd:cd17485 1 LLFGLYLAQGLPYGFQSQALPVLLRSAGVSLTAIGLLKLLYLPWVLKFLWAPLVDRYGLPRLGRRRSWLLPTQLGLALLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504695669 96 AAMGFLEPTTQLRWMAALAVVIAFCSASQDIVFDAWKTDVLPAEERGAGAAISVLGYRLGMLVSGGLALWLADrYLGWQG 175
Cdd:cd17485 81 LALAFLPPTTNLLAFLGLLFLLNLFSATQDIATDGLAVELLTPEERGLGNAAQVVGYKLGSLLGGGGLLWLYD-LIGWQS 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504695669 176 MYWLMAALLIPCIIATIFAPEPSDIIPVPRSLEQAVAEP-LRDFFGRNNAWLILLLIVLYKLGDAFAMSLTTTFLIrGVG 254
Cdd:cd17485 160 LLLSLAALYLLLLLPVLFLRELELPQQPPASERGAALKAsLRAFLRRPGTRWLLLFLLLYKLGEQGALAMLPPFLV-DRG 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504695669 255 FDAGEVGVVNKTLGLFATIVGALYGGVLMQRLTLFRALLIFGILQGASNAGYWLLSI--TDKHMISMAAAVFFENLCGGM 332
Cdd:cd17485 239 FSLSQIGLLSGVGGSLVSIAGSLLGGYLLKRRGRRRLLLLGGLLRLLLLGLYTLLALggSGLNWVLLLASLALLHLVGGM 318
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 504695669 333 GTAAFVALLMTLCNKSFSATQFALLSALSAVGRVYVGPIAGWFVEAHGWPTFYLFSVVAAVPGILLLL 400
Cdd:cd17485 319 ITTALFTLMMDCSQQAQAGTDYTLLATVEVLGKLLFGSLAGFLADHLGYAAAFLLFAILSALSVLLLL 386
|
|
| sider_RhtX_FptX |
TIGR02718 |
siderophore transporter, RhtX/FptX family; RhtX from Sinorhizobium meliloti 2011 and FptX from ... |
15-398 |
1.87e-29 |
|
siderophore transporter, RhtX/FptX family; RhtX from Sinorhizobium meliloti 2011 and FptX from Pseudomonas aeruginosa appear to be single polypeptide transporters, from the major facilitator family (see pfam07690) for import of siderophores as a means to import iron. This function was suggested by proximity to siderophore biosynthesis genes and then confirmed by study of knockout and heterologous expression phenotypes. [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 131765 Cd Length: 390 Bit Score: 119.23 E-value: 1.87e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504695669 15 AILLILGFASGLPLALTSGTLQAWMTVENIDLKTIGFFSLVGQAYVFKFLWSPVMDRYTPPFLGRRRGWLVMTQVLLLLA 94
Cdd:TIGR02718 4 ITLGLLYLSQGIPIGLAMDALPTLLREDGAPLTALAFLPLVGLPWVVKFLWAPLVDNWWSWRLGRRRSWVLPMQCLVSAC 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504695669 95 IAAMGFLEPT-TQLRWMAALAVVIAFCSASQDIVFDAWKTDVLPAEERGAGAAISVLGYRLGMLVSGGLALWLADRYlGW 173
Cdd:TIGR02718 84 LASLALVGPDvAGAGWAVGLLACASLASATQDIATDGMAAEHFNGRTLAKGNAVQIAGVMIGFFGGGAGTLVLFGKF-GQ 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504695669 174 QGMYWLMAAL-LIPCIIATIFAPEPSDIIPVPRSLEQAVAEplrdFFGRNNAWLILLLIVLYKLGDAFAMSLTTTFLIRG 252
Cdd:TIGR02718 163 RPAFLLVACVpLASLVCVLWLKDRAVASPEAPLARRASLFR----FFRRPLAWSLLALALLSAMTAVSGFGLSKLYLVDA 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504695669 253 vGFDAGEVGVVNKTLGLFATIVGALYGGVLMQRLTLFRALLIFGILQGAS------NAGYWLLSITDKHMismaAAVFFE 326
Cdd:TIGR02718 239 -GWPLEWIGRLGMAGGAVTVLLGCGGGAWLVRRAGLWRTFILGVGLAGSLallwfaQAAFWLAPGIAVAW----SCSAFG 313
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 504695669 327 NLCGGMGTAAFVALLMTLCNKSFSA-TQFALLSALSAVGRVYVGPIAGWFVEAHGWPTFYLFSVVAAVPGILL 398
Cdd:TIGR02718 314 SLITGITSVAIYTAFMRFAGDGDQAgTDVTAVQSTRDLGELIASSIAGYLTDRFGYAGGFLSGTVLAVLAILL 386
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
17-400 |
5.65e-19 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 88.64 E-value: 5.65e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504695669 17 LLILGFASGLPLALTSGTLQAWMTVENIDLKTIGFFSLVGQ--AYVFKFLWSPVMDRYtppflgRRRGWLVMTQVLLLLA 94
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSlgYALLQPLAGLLADRF------GRRPVLLLGLLLFALG 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504695669 95 IAAMGFLeptTQLRWMAALAVVIAFCSASQDIVFDAWKTDVLPAEERGAGAAISVLGYRLGMLVSGGLALWLADR-YLGW 173
Cdd:cd06174 75 ALLFAFA---PSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSlGFGW 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504695669 174 QGMYWLMAALLIPCIIATIFAPEPSDIIPVPRSLEQA---VAEPLRDFFGRNNAWLILLLIVLYKLGDAFAMSLTTTFLI 250
Cdd:cd06174 152 RAVFLIAAALALLAAILLLLVVPDPPESARAKNEEASsksVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLL 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504695669 251 RGVGFDAGEVGVVnKTLGLFATIVGALYGGVLMQRLTLFRALLIFGILQGASNAGYWLLSITDKHMISMAAAVFFenlCG 330
Cdd:cd06174 232 DLGGLSVAVAGLL-LSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGF---GL 307
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 504695669 331 GMGTAAFVALLMTLCNKSFSATQFALLSALSAVGRVYVGPIAGWF-VEAHGWPTFYLFSVVAAVPGILLLL 400
Cdd:cd06174 308 GGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLlAATFGLTGAFLVLAVLLLLAAILLL 378
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
17-366 |
4.45e-14 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 73.22 E-value: 4.45e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504695669 17 LLILGFASGLPLALTSGTLQAWMTVE-NIDLKTIGFFSLVGQ--AYVFKFLWSPVMDRYtppflGRRRgWLVMTQVLLLL 93
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDlGISPTEIGLLLTLFSlgYALAQPLAGRLSDRF-----GRRR-VLLIGLLLFAL 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504695669 94 AIAAMGFlepTTQLRWMAALAVVIAFCSASQDIVFDAWKTDVLPAEERGAGAAISVLGYRLGMLVSGGLALWLADrYLGW 173
Cdd:pfam07690 75 GLLLLLF---ASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLAS-LFGW 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504695669 174 QGMYWLMAALLIPCIIATIFAPEPSDIIPVPRSLEQAVAEPLRDFFGRNNAWLILLLIVLYKLGDAFAMSLTTTFLIRGV 253
Cdd:pfam07690 151 RAAFLILAILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVL 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504695669 254 GFDAGEVGVVnKTLGLFATIVGALYGGVLMQRLTLFRALLIFGILQGASNAGYWLLSITDKHMISMAAAVFFeNLCGGMG 333
Cdd:pfam07690 231 GLSALLAGLL-LGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLL-GFGFGLV 308
|
330 340 350
....*....|....*....|....*....|...
gi 504695669 334 TAAFVALLMTLCNKSFSATQFALLSALSAVGRV 366
Cdd:pfam07690 309 FPALNALVSDLAPKEERGTASGLYNTAGSLGGA 341
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
15-364 |
4.03e-12 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 67.31 E-value: 4.03e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504695669 15 AILLILGFASGLPLALTSGTLQAWMTVENIDLKTIGFFSLVGQ--AYVFKFLWSPVMDRYtppflGRRRgWLVMTQVLLL 92
Cdd:COG2814 13 LALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLlgAALGAPLAGRLADRF-----GRRR-VLLLGLLLFA 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504695669 93 LAIAAMGFlepTTQLRWMAALAVVIAFCSASQDIVFDAWKTDVLPAEERGAGAAISVLGYRLGMLVSGGLALWLADrYLG 172
Cdd:COG2814 87 LGSLLCAL---APSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLAD-LFG 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504695669 173 WQGMYWLMAALLIPCIIATIFApepsdIIPVPRSLEQAVAEPLRDFFGRNNAWLILLLIVLYKLGDAFAMSLTTTFLIRG 252
Cdd:COG2814 163 WRWVFLVNAVLALLALLLLLRL-----LPESRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEV 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504695669 253 VGFDAGEVGVVNkTLGLFATIVGALYGGVLMQRLTLFRALLIFGILQGASNAGYWLLSitdkHMISMAAAVFFENLCGGM 332
Cdd:COG2814 238 LGLSASAAGLLL-ALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAG----SLWLLLLALFLLGFGFGL 312
|
330 340 350
....*....|....*....|....*....|..
gi 504695669 333 GTAAFVALLMTLCNKSFSATQFALLSALSAVG 364
Cdd:COG2814 313 LFPLLQALVAELAPPEARGRASGLYNSAFFLG 344
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
19-400 |
5.33e-12 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 67.62 E-value: 5.33e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504695669 19 ILGFASG-LPLALTSGTLQAWM-----TVENIDLKTIGFFSLVgqAYVFKFLWSPVM----DRYTPPFlGRRRGWLVMTQ 88
Cdd:COG2211 12 KLAYGLGdLGLNLAFGLLSAYLlyfytDVLGLSAALVGLILLV--ARLWDAITDPLIgalsDRTRTRW-GRRRPWILIGA 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504695669 89 VLLLLAIAAMGF---LEPTTQLRWMAALAVVIAFCSASQDIVFDAWKTDVLP-AEERGAGAAISVLGYRLGMLVSGGLAL 164
Cdd:COG2211 89 IPLALSFVLLFTapdLSPTGKLIYALVTYLLLGLAYTLVNIPYSALGAELTPdYEERTRLSSWRFAFAGLGGLLASVLPP 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504695669 165 WLADRY-----LGWQGMYWLMAALLIPCIIATIFA-PEPsdiiPVPRSLEQAVAEPLRDFFGRNNAWLILLLIVLYKLGD 238
Cdd:COG2211 169 PLVAAFggdaaLGYRLTALIFAVLGLLAFLLTFFGtKER----PVPEEEKVSLKESLKALLKNRPFLLLLLAYLLFFLAL 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504695669 239 AFAMSLTTTFLIRGVGFDAGEVGVVNkTLGLFATIVGALYGGVLMQRLTLFRALLIFGILQGASNAGYWLLSITDKHMIS 318
Cdd:COG2211 245 ALVAALLLYYFKYVLGLSAALVGLLL-ALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPGNLWLLL 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504695669 319 MAAAVFFenLCGGMGTAAFVALLMTLC-------NKSFSATQFALLSALSAVGRVYVGPIAGWFVEAHGWPT-------- 383
Cdd:COG2211 324 VLAALAG--IGLGAILVLPWAMLADVVdydewktGRRREGLYFGIFTFAIKLGQALAGALAGLLLALFGYVAgaaqspsa 401
|
410
....*....|....*...
gi 504695669 384 -FYLFSVVAAVPGILLLL 400
Cdd:COG2211 402 lTGIRLLFFLLPAVLLLL 419
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
77-401 |
1.02e-10 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 63.36 E-value: 1.02e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504695669 77 LGRRRgWLVMTQVLLLLAIAAMGFLEPTTQLrwmAALAVVIAFCSASQDIVFDAWKTDVLPAEERGAGAAISVLGYRLGM 156
Cdd:COG2223 67 FGPRR-VLLIGLLLLGIGLLLLALAVSYWLL---LLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGA 142
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504695669 157 LVSGGLALWLADRYlGWQGMYWLMA-ALLIPCIIATIFAPEPsdiipvPRSLEQAVAEPLRDF---FGRNNAWLILLLIV 232
Cdd:COG2223 143 AVAAFLAPLLIAAF-GWRNAFLILGiLLLVVAVLAWLFLRDP------PAGAAAAAKASLRDQleaLRDPRFWLLSLLYF 215
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504695669 233 LYKLGDAFAMSLTTTFLIRGVGFDAGEVGVVNkTLGLFATIVGALYGGVLMQRLTLFRALLIFGILQGasnAGYWLLSIT 312
Cdd:COG2223 216 GTFGSFIGFSSWLPPYLVDQFGLSAATAGLLA-ALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMA---LGLLLLALA 291
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504695669 313 DKHMISMAAAVFFENLCGGMGTAAFVALLMTLCNKSFSATQFALLSALSAVGRVYVGPIAGWFVEAHGWPT--FYLFSVV 390
Cdd:COG2223 292 LGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTaaFLVFAVL 371
|
330
....*....|.
gi 504695669 391 AAVPGILLLLV 401
Cdd:COG2223 372 ALVALVLTLLL 382
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
67-401 |
8.48e-10 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 60.32 E-value: 8.48e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504695669 67 PVMDRYtppflgRRRGWLVMTQVLLLLAIAAMGFL--EPTTQLRWMAALAVVIAFCSASQDIVFDAWKTDVLPAEERGAG 144
Cdd:cd06173 56 VLADRF------DRRRLLILADLLRALLAAVLALLalLGSLSLWLLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRA 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504695669 145 AAISVLGYRLGMLVSGGLALWLADrYLGWQGMYWLMAALLIPCIIATIF--APEPSDIIPVPRSLEQAVAEPLRDFFGRN 222
Cdd:cd06173 130 NALNSLATQLARIIGPALGGLLVA-LLGPGGAFAINALSFLLSALLLLFirRPPPAAPGESSSLLLRDLREGLRYLRRSP 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504695669 223 NAWLILLLIVLYKLGDAFAMSLTTTFLIRGVGFDAGEVGVVNKTLGLfATIVGALYGGVLMQRLTLFRALLIFGILQGAS 302
Cdd:cd06173 209 LLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGV-GALLGALLLGRLSKRRRRGRLLLIGALLLGLA 287
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504695669 303 NAGYWLLSitdkHMISMAAAVFFENLCGGMGTAAFVALLMTLCNKSFSATQFALLSALSAVGRVYVGPIAGWFVEAHGWP 382
Cdd:cd06173 288 LLVLGLSP----SLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLS 363
|
330
....*....|....*....
gi 504695669 383 TFYLFSVVAAVPGILLLLV 401
Cdd:cd06173 364 AVFLLAGALLLLAALLLLL 382
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
28-401 |
1.42e-09 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 59.50 E-value: 1.42e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504695669 28 LALTSGTLQAWMTVENIDLKTIGFFSLVGQAyVFKFLWSPVMDRYtppflGRRRGWLVMTqVLLLLAIAAMGFlepTTQL 107
Cdd:COG2271 29 LSVAAPPLQADLGLSAAQLGLLASAFFLGYA-LGQIPAGLLADRF-----GRRRVLAIGL-LLWGLATLLFGF---ATSF 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504695669 108 RWMAALAVVIAFCSASQDIVFDAWKTDVLPAEERGAGAAISVLGYRLGMLVSGGLALWLADRYlGWQGMYWLMAALLIPC 187
Cdd:COG2271 99 WQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAF-GWRAAFLILGLPGLLL 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504695669 188 IIATIfapepsdiipvprsleqavaeplrdffgrnnaWLILLLIVLYKLGDAFAMSLTTTFLIRGVGFDAGEVGVVNkTL 267
Cdd:COG2271 178 ALLRF--------------------------------WLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLL-SL 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504695669 268 GLFATIVGALYGGVLMQRLTLFRALLIFGILQGASnAGYWLLSITDKHMISMAAAVFFeNLCGGMGTAAFVALLMTLCNK 347
Cdd:COG2271 225 PFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAA-LALLLLALLPSPALAIALLFLA-GFGLGGAFGLLWALAAELFPK 302
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 504695669 348 SFSATQFALLSALSAVGRVYVGPIAGWFVEAHGWPTFYLFSVVAAVPGILLLLV 401
Cdd:COG2271 303 KARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALL 356
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
15-403 |
2.25e-09 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 59.10 E-value: 2.25e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504695669 15 AILLILGFASGLPLALTSGTLQAWMTVENIDLKTIGFFSLVGQA--YVFKFLWSPVMDRYtppflGRRRGWLVMtqvLLL 92
Cdd:COG0738 11 IAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLgyLLASLPAGRLIDRF-----GYKRGLLLG---LLL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504695669 93 LAIAAMGFLEpTTQLRWMAALAVVIAFCSASQDIVFDAWKTDVlpaEERGAGAAISVLG--YRLGMLVSGGLALWLADRY 170
Cdd:COG0738 83 MALGLLLFAL-APSYPLLLLALFLLGLGLGLLDVAANPYVAAL---GPETAASRLNLLHafFSLGALLGPLLGGLLILLG 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504695669 171 LG--WQGMYWLMAALLIPCIIATIFAPEPSdiIPVPRSLEQAVAEPLRDFFGRNNAWLILLLIVLYKLGDAFAMSLTTTF 248
Cdd:COG0738 159 LSlsWHLPYLILAVLLLLLALLFLRSKLPE--IEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLY 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504695669 249 LIRGVGFDAGEVGVVNkTLGLFATIVGALYGGVLMQRLTLFRALLIFGILQGasnAGYWLLSITDKHMISMAAAVFFenl 328
Cdd:COG0738 237 LKDVLGLSEATAALGL-SLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAA---VGLLLALLAPGPWLALIGLALV--- 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504695669 329 cgGMGTAAFVALLMTLCNKSFSATQFALLSALSAVGrvYVG-----PIAGWFVEAHGWPTFYLFSVVAAVPGILLLLVCR 403
Cdd:COG0738 310 --GLGLSLMFPTIFSLALDGLGKRTAAAVSAVLIMG--IVGgaigpPLIGFLADAFGLRAAFLVPLVCYLLILLLALALK 385
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
60-403 |
1.48e-08 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 56.43 E-value: 1.48e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504695669 60 VFKFLWSPVMDRYtppflGRRRgwlVMTQVLLLLAIAAMGFLEpTTQLRWMAALAVVIAFCSASQDIVFDAWKTDVLPAE 139
Cdd:cd17325 46 LFSPPAGRLSDRF-----GRKR---LLLLGLLLLAVSTLLFAF-ATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPE 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504695669 140 ERGAGAAISVLGYRLGMLVSGGLALWLADRYlGWQGMYWLMAALLIPCIIATIFAPEPSDIIPVPRSLEQA-VAEPLRDF 218
Cdd:cd17325 117 ERGRAMGIFSSAIGLGFLIGPLLGGLLADAL-GYRAPFLVCAALALLALVLALLLLPEPRPPPNKRAVSAArLRSGLRLL 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504695669 219 FGRNNAWLILLLIVLYKLGDAFAMSLTTTFLIRGVGFDAGEVGVVNkTLGLFATIVGALYGGVLMQRLTlFRALLIFGIL 298
Cdd:cd17325 196 LRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLF-GAQGLASALSQPPAGKLSDRIG-RKPLILIGLL 273
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504695669 299 QGAsnAGYWLLSITDkHMISMAAAVFFENLCGGMGTAAFVALLMTLCNKSFSATQFALLSALSAVGRVyVGPI-AGWFVE 377
Cdd:cd17325 274 LSA--VALLLLPLAT-SFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMV-LGPLlGGFLYD 349
|
330 340
....*....|....*....|....*.
gi 504695669 378 AHGWPTFYLFSVVAAVPGILLLLVCR 403
Cdd:cd17325 350 AFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| Acatn |
pfam13000 |
Acetyl-coenzyme A transporter 1; The mouse Acatn is a 61 kDa hydrophobic protein with six to ... |
16-159 |
1.33e-07 |
|
Acetyl-coenzyme A transporter 1; The mouse Acatn is a 61 kDa hydrophobic protein with six to 10 transmembrane domains. It appears to promote 9-O-acetylation in gangliosides.
Pssm-ID: 372424 [Multi-domain] Cd Length: 543 Bit Score: 53.90 E-value: 1.33e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504695669 16 ILLILGFASGLPLALTSGT----LQAwmTVENIDLKTIGFFSLVGQAYVFKFLWSPVMDRYTPPFLGRRRGWLVMTQV-- 89
Cdd:pfam13000 3 LLVALYFLQGIPVGLAFGTipflLKS--MAKETSFTSLGIFSMATYPYSLKILWSPIVDSIYSKKIGRRRSWIIPVQLvs 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504695669 90 -LLLLAIAAM---GFLEP------------------TTQLRWMAALAVviaFCSASQDIVFDAWKTDVLPAEERGAGAAI 147
Cdd:pfam13000 81 gIMLIILGYCiskGLIFPgvddafhgrlskgvlnvnITTLTWYFGILV---FLCATQDIAVDGWALTILSKQSLSYASTA 157
|
170
....*....|..
gi 504695669 148 SVLGYRLGMLVS 159
Cdd:pfam13000 158 QTVGLNTGYFLS 169
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
134-400 |
2.08e-05 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 46.77 E-value: 2.08e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504695669 134 DVLPAEERGAGAAISVLGYRLGMLVSGGLALWLADrYLGWQGMYWLMAALLIPCIIATIFAPEPsdiIPVPRSLEQAVAE 213
Cdd:cd17324 114 DLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQ-LLGWRAAFLAIAVLALLAALLLWRLLPS---LPPKKPGSLGLLS 189
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504695669 214 PLRDFFGRNNAWLILLLIVLYKLGDAFAMSLTTTFLIRGVGFDAGEVGVVnktLGLF--ATIVGALYGGVLMQRLtLFRA 291
Cdd:cd17324 190 SLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGL---LLLFgvAGVVGSPLAGRLADRG-GRRA 265
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504695669 292 LLIFGILQGASnagYWLLSITDKHMISMAAAVFFENLCGGMGTAAFVALLMTLcNKSFSATQFALLSALSAVGRVYVGPI 371
Cdd:cd17324 266 LLIALLLLAAA---LLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRL-APEARGLASSLYLAAYNLGGALGAAL 341
|
250 260
....*....|....*....|....*....
gi 504695669 372 AGWFVEAHGWPTFYLFSVVAAVPGILLLL 400
Cdd:cd17324 342 GGLVLDHGGWAGVGWVGAALLLLALLLAL 370
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
15-399 |
5.79e-05 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 45.24 E-value: 5.79e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504695669 15 AILLILGFASGLPLALTSgtlqAWMTVENIDLKTIGFFSLVgqAYVFKFLWSPVMDRYTppflgRRRGWLVMTQVLLLLA 94
Cdd:cd17477 3 LSVALLGLGSGLLLPLLS----LRLEREGVSTALIGLVASA--YYLGILLGSPLVPRLI-----RRVGHIRAFAAGAAIT 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504695669 95 IAAMGFLEPTTQLRWMAALAVVIAFCSASQDIVFDAWKTDVLPAEERGAGAAISVLGYRLGMLVsGGLALWLADrYLGWQ 174
Cdd:cd17477 72 AVSVLLLALTDSPWVWFLLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFAL-GPLLLALVG-TAGAL 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504695669 175 gMYWLMAALLIPCIIATIFAPEPSDIIPVPRSLeqavaePLRDFFGRnnAWLILLLIVLYKLGDAFAMSLTTTFLIRgVG 254
Cdd:cd17477 150 -PFLIAAVLLLLALVPLLLTRRAAPEIEEAESI------SLRRLLRI--APLALLGAFVAGFLEGAFYSLLPLYGLR-LG 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504695669 255 FDAGEVGVVnKTLGLFATIVGALYGGVLMQRLTLFRALLIFGILQGASNAGYWLLSitdkHMISMAAAVFFenLCGGMGT 334
Cdd:cd17477 220 LSVAQAALL-LAAFVLGGLLLQWPLGWLADRFDRRRVLLGCALLGALAALLLPLVP----GLPLALLVLLF--LWGGAAG 292
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 504695669 335 AAFvALLMTLCNKSFSATQF----ALLSALSAVGRVYVGPIAGWFVEAHGWPTFYLFSVVAAVPGILLL 399
Cdd:cd17477 293 PLY-TLALALAGDRLPGDELvaanAALLLLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAVALLFLLFL 360
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
39-195 |
5.92e-05 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 45.25 E-value: 5.92e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504695669 39 MTVENIDLKTIGFFSLVGQ--AYVFKFLWSPVMDRytppfLGRRRGWLVMtqVLLLLAIAAMGFLEPTTQLRWMAALAVV 116
Cdd:COG2271 208 VEVRGLSLAQAGLLLSLPFlaGIVGSLLGGWLSDR-----LGRRRKLVLA--IGLLLAALALLLLALLPSPALAIALLFL 280
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 504695669 117 IAFCSASQDIVFDAWKTDVLPAEERGAGAAISVLGYRLGMLVSGGLALWLADRYlGWQGMYWLMAALLIPCIIATIFAP 195
Cdd:COG2271 281 AGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDAT-GYQAAFLLLAALALLAALLALLLL 358
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
77-400 |
1.30e-04 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 44.12 E-value: 1.30e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504695669 77 LGRRRGWLVMTQVLLLLAIAAMGFLEPTTQLRWMAALAVVIAFCSASQDIVFDAWKTDVLPAEERGAGAAISVLGYRLGM 156
Cdd:cd17489 54 LLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAM 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504695669 157 LVSGGLALWLADRYlGWQGMYWLMAALLIPCIIATIFAPEPsdiiPVPRSLEQAVAEPLRDFFGRNNAWLILLLIVLYkl 236
Cdd:cd17489 134 ALGPALGLFLYQHL-GFAVLFIVAAVLALLALLLVFLVKDP----PPVAAEEAEAGTRAFRRLVEKKVLPPALILFLA-- 206
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504695669 237 gdAFAMSLTTTFLirgvGFDAGEVGVVNKtlGLF------ATIVGALYGGVLMQRLTLFRALLIFGILQGasnAGYWLLS 310
Cdd:cd17489 207 --SIAYGAISTFL----PLYAAERGISNA--GLFftvyaiALLLSRPFSGKLSDRKGPKTVIIPGLLLLA---LGLLLLS 275
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504695669 311 ITDKHMISMAAAVFFeNLCGGMGTAAFVALLMTLCNKSFSATQFALLSALSAVGRVYVGPIAGWFVEAHGWPTFYLFSVV 390
Cdd:cd17489 276 FAGSPWMLLLAAVLY-GLGFGLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAV 354
|
330
....*....|
gi 504695669 391 AAVPGILLLL 400
Cdd:cd17489 355 VVLLALVLYI 364
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
223-448 |
1.34e-04 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 44.19 E-value: 1.34e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504695669 223 NAWLILLLIVLYKLGDAFAMSLTTTFL---IRGVGFDAGEVGVVNkTLGLFATIVGALYGGVLMQRLTLFRALLIFGILQ 299
Cdd:COG2814 7 RRWLALLALALGAFLSGLGIGIVLPALpliAADLGASPAQAGLVV-TAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLF 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504695669 300 GASNAGYWLLSitdkHMISMAAAVFFENLCGGMGTAAFVALLMTLCNKSFSATQFALLSALSAVGRVYVGPIAGWFVEAH 379
Cdd:COG2814 86 ALGSLLCALAP----SLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLF 161
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 504695669 380 GWPTFYLFSVVAAVPGILLLLVCRQTLEYTQRTEHFMPRTEYHTAYRFALRLLMVGCVALALWLVVLII 448
Cdd:COG2814 162 GWRWVFLVNAVLALLALLLLLRLLPESRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYL 230
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
90-400 |
1.78e-04 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 43.69 E-value: 1.78e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504695669 90 LLLLAIAAMGFLEPTTQLRWMAALAVVIAFCSASQDIVFdAWKTDVLPAE-ERGAGAAISVL--GYRLGMLVSGGLALWL 166
Cdd:cd17471 70 LLAGALGYLLFAFLRNYWVLLLVGVVLLSLGAAAFPQLF-ALAREYADRSsGRDATLFNSVLraAFSLAWVIGPPLAFLL 148
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504695669 167 ADrYLGWQGMYWLMAALLIPCIIATIFAPePSDIIPVPRSLEQAVAEPLRDffgRNNAWLILLLIVLYKLGDAFAMSLTT 246
Cdd:cd17471 149 LD-VLGFTGLFLLAALLYLVVALLVLFLL-PSVKPPAQKATPASSLVKAPV---NRRLLLLFAAFTLLFAANSMYIIAMP 223
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504695669 247 TFLIRGVGFDAGEVGVVNkTLGLFATIVGALYGGVLMQRLTLfRALLIFGILQGAsnaGYWLLSITDKHMISMAAAVFFE 326
Cdd:cd17471 224 LYVTNELGGSESWVGLLF-GLAAALEIPIMLLAGLLAKRFGK-RRLLLAGFLAGV---LFYLGLALATSLWQLIALQLLN 298
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 504695669 327 nlcgGMGTAAFVALLMTLC-----NKSFSATqfALLSALSAVGRVYVGPIAGWFVEAHGWPTFYLFSVVAAVPGILLLL 400
Cdd:cd17471 299 ----AIFIGITAGLGISYFqdlmpGQPGLAT--TLYSNASRIGSLLGGLLAGVIAQYFGYRAVFLVCAVLALLALVLLL 371
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
136-401 |
2.08e-04 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 43.33 E-value: 2.08e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504695669 136 LPAEERGAGAAISVLGYRLGMLVSGGLALWLADrYLGWQGMYWLMAallIPCIIATIFApepsdiipvprsleqavaepl 215
Cdd:cd17319 120 FPARERGRATGLFNSGAPLGAAIGPPLSGWLLL-LFGWRWAFIIEG---LLGLLLAVLW--------------------- 174
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504695669 216 rdFFGRNNAWLILLLIVLYKLGDAFAMSLTTTFLIRGVGFDAGEVGVVNkTLGLFATIVGALYGGVLMQRLTLFRALLIF 295
Cdd:cd17319 175 --WFYLRQVWGLALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLA-AIPFLAGAIGMILGGRLSDRLLRGARRLVI 251
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504695669 296 GILQGASNAGYWLLSITDKHMISMaAAVFFENLCGGMGTAAFVALLMTLCNKSFSATQFALLSALSAVGRVYVGPIAGWF 375
Cdd:cd17319 252 IIGLLLAAVGLLLAYLTTSPVVAV-ILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYL 330
|
250 260
....*....|....*....|....*...
gi 504695669 376 VEAHGWPT--FYLFSVVAAVPGILLLLV 401
Cdd:cd17319 331 VDATGSYTaaFLFLAAVALLAALLVLLL 358
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
84-401 |
2.21e-04 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 43.41 E-value: 2.21e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504695669 84 LVMTQVLLLLAIAAMGFLEPTTQLRWMAALAVVIAFCSASQDIVFDAWKTDVLPAEERGAGAAISVLGYRLGMLVSGGLA 163
Cdd:cd17355 69 RVMLLGLLLLAAGLVLLALATSLWQLYLLWGLLGGGGAGTLAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLG 148
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504695669 164 LWLADRYlGWQGMYWLMAALLIPCIIATIFA----PEPSDIIPVPRSLEQAVAEPLRDFFGRNNAWLILLLIVLYKLGDA 239
Cdd:cd17355 149 AALIEAF-GWRTALLVLALLALLVLVPVLLLlrrrPADLALRAYDDASPASPGSTLKEALRSASFWLLALAFFLCGFAVV 227
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504695669 240 FaMSLTTTFLIRGVGFDAGEVGVVNKTLGLFAtIVGALYGGVLMQRLTLFRALLIFGILQGASNAGYWLLSITdkhMISM 319
Cdd:cd17355 228 G-LIVHLVPYLADRGISPAAAAVALALIGLFN-IVGRLLSGWLGDRYSPRRLLAASYALRALGLALLLLLPFP---PLAL 302
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504695669 320 AAAVFFENLCGGMGTAAFVALLMTLCNKSFSATQFALLSALSAVGRVYVGPIAGWFVEA-HGWPTFYLFSVVAAVPGILL 398
Cdd:cd17355 303 LLFAALFGLGWGATVPLTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRtGSYTAAWALAVALGLIAALL 382
|
...
gi 504695669 399 LLV 401
Cdd:cd17355 383 VLP 385
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
139-401 |
4.42e-04 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 42.60 E-value: 4.42e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504695669 139 EERGAGAAISVLGYRLGMLVSGGL-ALWLADRYLGWQGMYWLMAALLIPCIIATIFAPEPSDIIPVPRSLEQAVAEPLRD 217
Cdd:cd17353 123 DKRGLATGIVIAGFGLGSLIFSPLiAYLINTVGVPTTFLILGIIFLIIIVIGAFLIRDPPKGWVPPGVDPLANNAENSPR 202
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504695669 218 FFGRNNA------WLILLLIVLYKLGDAFAMSLTTTFLIRGVGFDAGEVGVVNKTLGLFaTIVGALYGGVLMQRLTLFRA 291
Cdd:cd17353 203 DYTPREMlrtptfWLLWLMFFLNATAGLMLIGQAKPIGQEFAGLDAGIAALAVSILSIF-NGGGRPFWGWLSDKIGRKNT 281
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504695669 292 LLIFGILQGAsnaGYWLLSITDKHMISMAAAVFFENLCGGMGTAAFVALLMTLCNKSFSATQFALLSALSAVGRVYVGPI 371
Cdd:cd17353 282 LSIAFLIQGV---AMFLLPFIGSVAVLFVLGVALIGFCYGGGFALFPALTADFFGTKNAGTNYGLLYTAKGVGGLIGPII 358
|
250 260 270
....*....|....*....|....*....|.
gi 504695669 372 AGWFVEAHGW-PTFYLFSVVAAVPGILLLLV 401
Cdd:cd17353 359 AAYVLYTGGYnAAFIIAAALSLVALALALLL 389
|
|
| MFS_2 |
pfam13347 |
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ... |
78-402 |
7.26e-04 |
|
MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.
Pssm-ID: 433134 [Multi-domain] Cd Length: 427 Bit Score: 41.91 E-value: 7.26e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504695669 78 GRRRGWLVMTQVLLLLAIAAM---GFLEPTTQLRWMAALAVVIAFCSASQDIVFDAW---KTDvlPAEER----GAGAAI 147
Cdd:pfam13347 65 GRRRPWLLLSAIILAVSFILLftpPELGRAPLFIWLLATYILLRIAYTFFEIPYWSLgpeLTR--DYDERtsltSYRSFF 142
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504695669 148 SVLGYRLGMLVSGGLALWLADRYL---GWQGMYWLMAALLIPCIIATIFAPEPSDIIPVPRSLEQAVAEPLRDFFG---R 221
Cdd:pfam13347 143 SVGGGLLAAALAFPLVLILGGTGLerkGYRIFALIGAVLMLLGVIITAAGTKERVSMRSKEDTGQKEAGSLLDMLKevfR 222
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504695669 222 NNAWLILLLIVLYKLGDAFAMSLTTTFLIRGVGFDAGEVGVVNkTLGLFATIVGALYGGVLMQRLTLFRALLIFGILQGA 301
Cdd:pfam13347 223 NRAFLILLASFLLAALAMGVLNGLLLYYFRYVLGNGFAASAFP-LVFTIGALLGIPLWPPLAKRIGKKNTYILGALITIA 301
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504695669 302 SNAGYWLLSITDkhMISMAAAVFFENLCGGMGTAAFVALLMTLCNKSF-------SATQFALLSALSAVGRVYVGPIAGW 374
Cdd:pfam13347 302 GFALALLLGPNN--TLLFLVLYIIIGFGYGSSFFLPWSMLADVVDYGElrtgkrrEGTFFAMWSFISKLATGVGLGVSGL 379
|
330 340 350
....*....|....*....|....*....|....*..
gi 504695669 375 FVEAHGWPT---------FYLFSVVAAVPGILLLLVC 402
Cdd:pfam13347 380 LLSAFGYNAgdsvqspqaVTAIRLLYAVLPAVLFLVA 416
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
227-441 |
8.68e-04 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 41.63 E-value: 8.68e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504695669 227 ILLLIVLYKLGDAFAMSLTTTFLIRGVGFDAGEVGVVNkTLGLFATIVGALYGGVLMQRLTLFRALLIFGILQGASNAGY 306
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLL-TLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504695669 307 WLLSitdkHMISMAAAVFFENLCGGMGTAAFVALLMTLCNKSFSATQFALLSALSAVGRVYVGPIAGWFVEAHGWPTFYL 386
Cdd:pfam07690 80 LFAS----SLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFL 155
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 504695669 387 FSVVAAVPGILLLLVCRQTLEYTQRTEHFMPRTEYHTAYRFALRLLMVGCVALAL 441
Cdd:pfam07690 156 ILAILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALL 210
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
76-402 |
1.67e-03 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 40.67 E-value: 1.67e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504695669 76 FLGRRRGWLVMTQVLLLLAIAAMGFLEPTtqlrWMAALAVVIAFCSASQDIVFDAWKTDVLPAEERGAGAAISVLGYRLG 155
Cdd:cd17490 57 RIGKRKLFIIIGLLFTVLASLIMILFPSP----WGLLIARFLSGIAAATWVSFTVLYASYFPPDEAAKAMGLINLVNNLG 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504695669 156 MLVsGGLALWLADRYLGWQGMYWLMAALLIPCIIATIFAPEPSDI-IPVPRSLEQavaepLRDFFGRNNAWLI-LLLIVL 233
Cdd:cd17490 133 QLI-AFLIGGLIAEHFGMRAPFLLAALAGVLGFILSLFIKEERREkKPVLTELKE-----LLSVLKDKKLLFFsLLAILQ 206
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504695669 234 YKLGDAFAMSLTTTFLiRGVGFDAGEVGVVNKTLGLFATIVGALYGGVLMQRLTLFRALLIFGILQGASNAGYWLLSITd 313
Cdd:cd17490 207 QMITFSTTFGFTPLIA-KQLGASSFQLGLLSIIYLLPNALASLLSGTLFYKKLGERNTIIIGFLLLGAYCFLIPFAPNL- 284
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504695669 314 khmismaAAVFFENLCGGMGTAAFVALLMTLCNKSFS----ATQFALLSALSAVGrVYVGPI-AGWFVEAHGWPT-FYLF 387
Cdd:cd17490 285 -------TLLYLLQALNGFGTGILFPLLMSLSIEGVPaeqrSTAMGFFQAIYALG-MFLGPVlVGIISEAFGLQTgFFVI 356
|
330
....*....|....*
gi 504695669 388 SVVAAVPGILLLLVC 402
Cdd:cd17490 357 GVIALLAAILSLAYY 371
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
44-193 |
2.61e-03 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 39.86 E-value: 2.61e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504695669 44 IDLKTIGFFSLVGQ--AYVFKFLWSPVMDRytppFLGRRRGWLVMtqVLLLLAIAAMGFLEPTTQLRWMAALAVVIAFCS 121
Cdd:cd17319 212 FSLKQVGLLAAIPFlaGAIGMILGGRLSDR----LLRGARRLVII--IGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGI 285
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 504695669 122 ASQDIVFDAWKTDVLPAEERGAGAAISVLGYRLGMLVSGGLALWLADRYLGWQGMYWLMAALLIPCIIATIF 193
Cdd:cd17319 286 GAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATGSYTAAFLFLAAVALLAALLVLL 357
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
266-458 |
3.10e-03 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 39.91 E-value: 3.10e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504695669 266 TLGLFATIVGALYGGVLMQRLTLFRALLIFGILQGASNAGYWLLSITDKH-MISMAAAVFFENLCGGMGTAAFVALLMTL 344
Cdd:cd06173 41 AAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLALLGSLsLWLLLVLAFLLGIASAFFGPARQALLPEL 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504695669 345 CNKSFSATQFALLSALSAVGRVYVGPIAGWFVEAHGWPTFYLFSVVAAVPGILLLLVCRQTLEYTQRTEHFMPRTEYHTA 424
Cdd:cd06173 121 VPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALSFLLSALLLLFIRRPPPAAPGESSSLLLRDLREG 200
|
170 180 190
....*....|....*....|....*....|....
gi 504695669 425 YRFALRLLMVGCVALALWLVVLIINASTSLALPF 458
Cdd:cd06173 201 LRYLRRSPLLRLLLLALALFALLGGALTVLLPLL 234
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
63-400 |
4.00e-03 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 39.51 E-value: 4.00e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504695669 63 FLWSPVMDRYtppflGRRRGwLVMTQVLLLLAIAAMGFLEPTTqlrWMAALAVVIAFCSASQDIVFDAWKTDVLPAEERG 142
Cdd:cd17316 54 LLFGYLGDRI-----GRKKA-LILTLLLFGLATLLIGLLPTPI---LLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRG 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504695669 143 AGAAISVLGYRLGMLVSGGLALWLADRYLGWQGMYWLMAALLIPCIIAtifapepsdiipvprsleqavaeplrdFFGRN 222
Cdd:cd17316 125 FALGLLQSGWALGALLAALVASLLIPLLSGDWGWRILFLIGALPALLA---------------------------LLLRR 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504695669 223 NAWLILLLIVLYKLGDAFAMSLTTTFLIRGVGFDAGEVGVVNkTLGLFATIVGALYGGVLMQRLTLFRALLIFGILQGAS 302
Cdd:cd17316 178 RTLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYL-LLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGIL 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504695669 303 NAGYWLLSITDKHMISMAAAVFFenLCGGMGTAAFVALLMTLCNKSFSATQFALLSALSAVGRVYVGPIAGWFVEAHG-W 381
Cdd:cd17316 257 ALPLFYLLSGSPTLLLLLLFILS--FFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGgT 334
|
330
....*....|....*....
gi 504695669 382 PTFYLFSVVAAVPGILLLL 400
Cdd:cd17316 335 GVPALILALLAIVALIVAL 353
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
15-197 |
4.02e-03 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 39.48 E-value: 4.02e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504695669 15 AILLILGFASGLPLALTSGTLqaWMTVENIDLKTIGFFSLVGQ--AYVFKFLWSPVMDRytppfLGRRRGWLVMtqvLLL 92
Cdd:COG2223 211 SLLYFGTFGSFIGFSSWLPPY--LVDQFGLSAATAGLLAALFAllGALGRPLGGWLSDR-----IGGRRVLLIV---FAL 280
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504695669 93 LAIAAMGFLEPTTQLRWMAALAVVIAFCSASQDIVFDAWKTDVLPAEERGAGAAISVLGYRLGMLVSGGLALWLADRYLG 172
Cdd:COG2223 281 MALGLLLLALALGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGS 360
|
170 180
....*....|....*....|....*
gi 504695669 173 WQGMYWLMAALLIPCIIATIFAPEP 197
Cdd:COG2223 361 YTAAFLVFAVLALVALVLTLLLYRR 385
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
225-403 |
8.86e-03 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 38.49 E-value: 8.86e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504695669 225 WLILLLIVLYKLGDAF---AMSLTTTFLIRGVGFDAGEVGVVNkTLGLFATIVGALYGGVLMQRLTLFRALLIFGILQGa 301
Cdd:TIGR00895 16 WRAIILSFLIMLMDGYdlaAMGFAAPAISAEWGLDPVQLGFLF-SAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFS- 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504695669 302 snaGYWLLSITDKHMISMAAAVFFENLCGGMGTAAFVALLMTLCNKSFSATQFALLSALSAVGRVYVGPIAGWFVEAHGW 381
Cdd:TIGR00895 94 ---VFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGW 170
|
170 180
....*....|....*....|..
gi 504695669 382 PTfyLFSVVAAVPGILLLLVCR 403
Cdd:TIGR00895 171 RS--LFYVGGIAPLLLLLLLMR 190
|
|
| |
