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Conserved domains on  [gi|504696500|ref|WP_014883602|]
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MULTISPECIES: mechanosensitive ion channel family protein [Enterobacter]

Protein Classification

mechanosensitive ion channel family protein( domain architecture ID 11430441)

mechanosensitive ion channel family protein is a conductance mechanosensitive channel that opens in response to stretch forces in the membrane lipid bilayer, and may be anion or cation selective

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
MscS COG0668
Small-conductance mechanosensitive channel [Cell wall/membrane/envelope biogenesis];
87-351 4.66e-61

Small-conductance mechanosensitive channel [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 440432 [Multi-domain]  Cd Length: 276  Bit Score: 197.41  E-value: 4.66e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504696500  87 FVDLPDHLFGTVSHAWFLVFAIQVALWMDQGVVSWLRHVMLApgSHKNPVTLVITGLILRAIVWSVMLLSILANAGVNIT 166
Cdd:COG0668   13 LLLLGELLLALLPKLLLALLILLIGWLLIRLLRRLIRRLLRR--ARRDRTLLPLLRNILKILIVIIAILLILSILGVNIT 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504696500 167 ALVASLGVGGIAIALAVQTILSDVFASLSIGFDKPFEIGDFVVFNDVAGTVEHIGLKTTRIRSLSGEQIVCGNAILLQQT 246
Cdd:COG0668   91 SLLAGLGAAGLAIGLAAQDLLSNFIAGIFILLERPFRVGDWIEVGGVEGTVEEIGLRSTRLRTLDGRLVTIPNSKILSSP 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504696500 247 LHNYKRMQTRRIVFTFGVASDTPPDKLRyvgDMVRQIITDVGETKFDRA--HFLGFDRDRLTFEVVHIVNTADynkYMDI 324
Cdd:COG0668  171 ITNYSRGPTRRVDVTIGVDYDTDIDKAR---ELLKEILEELPRILKDPAvvGVTELGDSSVNLRVRAWTKPGD---YWDV 244
                        250       260
                 ....*....|....*....|....*..
gi 504696500 325 QQEINIRILEGLNAQEIKLALPSMVLH 351
Cdd:COG0668  245 RRDIRERIKAALDEAGIEIPFPTRTVH 271
 
Name Accession Description Interval E-value
MscS COG0668
Small-conductance mechanosensitive channel [Cell wall/membrane/envelope biogenesis];
87-351 4.66e-61

Small-conductance mechanosensitive channel [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440432 [Multi-domain]  Cd Length: 276  Bit Score: 197.41  E-value: 4.66e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504696500  87 FVDLPDHLFGTVSHAWFLVFAIQVALWMDQGVVSWLRHVMLApgSHKNPVTLVITGLILRAIVWSVMLLSILANAGVNIT 166
Cdd:COG0668   13 LLLLGELLLALLPKLLLALLILLIGWLLIRLLRRLIRRLLRR--ARRDRTLLPLLRNILKILIVIIAILLILSILGVNIT 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504696500 167 ALVASLGVGGIAIALAVQTILSDVFASLSIGFDKPFEIGDFVVFNDVAGTVEHIGLKTTRIRSLSGEQIVCGNAILLQQT 246
Cdd:COG0668   91 SLLAGLGAAGLAIGLAAQDLLSNFIAGIFILLERPFRVGDWIEVGGVEGTVEEIGLRSTRLRTLDGRLVTIPNSKILSSP 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504696500 247 LHNYKRMQTRRIVFTFGVASDTPPDKLRyvgDMVRQIITDVGETKFDRA--HFLGFDRDRLTFEVVHIVNTADynkYMDI 324
Cdd:COG0668  171 ITNYSRGPTRRVDVTIGVDYDTDIDKAR---ELLKEILEELPRILKDPAvvGVTELGDSSVNLRVRAWTKPGD---YWDV 244
                        250       260
                 ....*....|....*....|....*..
gi 504696500 325 QQEINIRILEGLNAQEIKLALPSMVLH 351
Cdd:COG0668  245 RRDIRERIKAALDEAGIEIPFPTRTVH 271
MS_channel pfam00924
Mechanosensitive ion channel; Two members of this protein family: Swiss:Q57634 and Swiss: ...
144-342 6.68e-54

Mechanosensitive ion channel; Two members of this protein family: Swiss:Q57634 and Swiss:Q58543 of M. jannaschii have been functionally characterized. Both proteins form mechanosensitive (MS) ion channels upon reconstitution into liposomes and functional examination by the patch-clamp technique. Therefore this family are likely to also be MS channel proteins.


Pssm-ID: 459999 [Multi-domain]  Cd Length: 203  Bit Score: 176.64  E-value: 6.68e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504696500  144 ILRAIVWSVMLLSILANAGVNITALVASLGVGGIAIALAVQTILSDVFASLSIGFDKPFEIGDFVVFNDVAGTVEHIGLK 223
Cdd:pfam00924   3 ILKYLIIVVGILIVLSYLGVNVSALLAGLGALGLALGFALQDLVSNLVSGIIILFEKPFKIGDWIEIGDIEGTVEDIGLR 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504696500  224 TTRIRSLSGEQIVCGNAILLQQTLHNYKRMQTRRIVFTFGVASDTPPDKLRYVGDMVRQIITDVGETKFD---RAHFLGF 300
Cdd:pfam00924  83 TTTIRTFDGRLVTIPNSSILTSNIINYSRSPTRRVELSIGVAYSSDPDKLEKVIEILKEAAYEHPLVLKDpepPVVFGEF 162
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 504696500  301 DRDRLTFEVVHIVNTaDYNKYMDIQQEINIRILEGLNAQEIK 342
Cdd:pfam00924 163 GDSSLNFELRVWVKT-LPGEYFNVRSELNLRIKKALEENGIE 203
PRK10334 PRK10334
small-conductance mechanosensitive channel MscS;
144-290 3.47e-15

small-conductance mechanosensitive channel MscS;


Pssm-ID: 182386 [Multi-domain]  Cd Length: 286  Bit Score: 74.96  E-value: 3.47e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504696500 144 ILRAIVWSVMLLSILANAGVNITALVASLGVGGIAIALAVQTILSDVFASLSIGFDKPFEIGDFVVFNDVAGTVEHIGLK 223
Cdd:PRK10334  72 LVRYGIIAFTLIAALGRVGVQTASVIAVLGAAGLAVGLALQGSLSNLAAGVLLVMFRPFRAGEYVDLGGVAGTVLSVQIF 151
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 504696500 224 TTRIRSLSGEQIVCGNAILLQQTLHNYKRMQTRRIVFTFGVASDTPPDKlryvgdmVRQIITDVGET 290
Cdd:PRK10334 152 STTMRTADGKIIVIPNGKIIAGNIINFSREPVRRNEFIIGVAYDSDIDQ-------VKQILTNIIQS 211
 
Name Accession Description Interval E-value
MscS COG0668
Small-conductance mechanosensitive channel [Cell wall/membrane/envelope biogenesis];
87-351 4.66e-61

Small-conductance mechanosensitive channel [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440432 [Multi-domain]  Cd Length: 276  Bit Score: 197.41  E-value: 4.66e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504696500  87 FVDLPDHLFGTVSHAWFLVFAIQVALWMDQGVVSWLRHVMLApgSHKNPVTLVITGLILRAIVWSVMLLSILANAGVNIT 166
Cdd:COG0668   13 LLLLGELLLALLPKLLLALLILLIGWLLIRLLRRLIRRLLRR--ARRDRTLLPLLRNILKILIVIIAILLILSILGVNIT 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504696500 167 ALVASLGVGGIAIALAVQTILSDVFASLSIGFDKPFEIGDFVVFNDVAGTVEHIGLKTTRIRSLSGEQIVCGNAILLQQT 246
Cdd:COG0668   91 SLLAGLGAAGLAIGLAAQDLLSNFIAGIFILLERPFRVGDWIEVGGVEGTVEEIGLRSTRLRTLDGRLVTIPNSKILSSP 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504696500 247 LHNYKRMQTRRIVFTFGVASDTPPDKLRyvgDMVRQIITDVGETKFDRA--HFLGFDRDRLTFEVVHIVNTADynkYMDI 324
Cdd:COG0668  171 ITNYSRGPTRRVDVTIGVDYDTDIDKAR---ELLKEILEELPRILKDPAvvGVTELGDSSVNLRVRAWTKPGD---YWDV 244
                        250       260
                 ....*....|....*....|....*..
gi 504696500 325 QQEINIRILEGLNAQEIKLALPSMVLH 351
Cdd:COG0668  245 RRDIRERIKAALDEAGIEIPFPTRTVH 271
MS_channel pfam00924
Mechanosensitive ion channel; Two members of this protein family: Swiss:Q57634 and Swiss: ...
144-342 6.68e-54

Mechanosensitive ion channel; Two members of this protein family: Swiss:Q57634 and Swiss:Q58543 of M. jannaschii have been functionally characterized. Both proteins form mechanosensitive (MS) ion channels upon reconstitution into liposomes and functional examination by the patch-clamp technique. Therefore this family are likely to also be MS channel proteins.


Pssm-ID: 459999 [Multi-domain]  Cd Length: 203  Bit Score: 176.64  E-value: 6.68e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504696500  144 ILRAIVWSVMLLSILANAGVNITALVASLGVGGIAIALAVQTILSDVFASLSIGFDKPFEIGDFVVFNDVAGTVEHIGLK 223
Cdd:pfam00924   3 ILKYLIIVVGILIVLSYLGVNVSALLAGLGALGLALGFALQDLVSNLVSGIIILFEKPFKIGDWIEIGDIEGTVEDIGLR 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504696500  224 TTRIRSLSGEQIVCGNAILLQQTLHNYKRMQTRRIVFTFGVASDTPPDKLRYVGDMVRQIITDVGETKFD---RAHFLGF 300
Cdd:pfam00924  83 TTTIRTFDGRLVTIPNSSILTSNIINYSRSPTRRVELSIGVAYSSDPDKLEKVIEILKEAAYEHPLVLKDpepPVVFGEF 162
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 504696500  301 DRDRLTFEVVHIVNTaDYNKYMDIQQEINIRILEGLNAQEIK 342
Cdd:pfam00924 163 GDSSLNFELRVWVKT-LPGEYFNVRSELNLRIKKALEENGIE 203
MscK COG3264
Small-conductance mechanosensitive channel MscK [Cell wall/membrane/envelope biogenesis];
103-364 7.05e-42

Small-conductance mechanosensitive channel MscK [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442495 [Multi-domain]  Cd Length: 281  Bit Score: 147.65  E-value: 7.05e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504696500 103 FLVFAIQVALWMDQGVVSWLRHVMLaPGSHKNPVTLVITGLILRAIVWSVMLLSILANAGVNITALVASLGVGGIAIALA 182
Cdd:COG3264   25 LALLILVVTYLLARLLSRLLERRLL-RRTRLDPGLRYLISKLIRYLIIVLGLLIALSALGIDLTALAALAGALGVGIGFG 103
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504696500 183 VQTILSDVFASLSIGFDKPFEIGDFVVFNDVAGTVEHIGLKTTRIRSLSGEQIVCGNAILLQQTLHNY-KRMQTRRIVFT 261
Cdd:COG3264  104 LQDIVSNFISGLILLFERPFRVGDWIEIGGTEGTVEEIGLRSTRIRTFDGEEVIIPNSELITNPVINWsLSDPRRRVEIP 183
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504696500 262 FGVASDTPPDKlryvgdmVRQIITDVGETKFD-------RAHFLGFDRDRLTFEVVhiVNTADYNKYMDIQQEINIRILE 334
Cdd:COG3264  184 VGVAYGSDLEK-------VRELLLEAAREHPRvlkdpapSVLFTEFGDSSVNFELR--FWVNDPRDRLRVRSDLNEAIKK 254
                        250       260       270
                 ....*....|....*....|....*....|
gi 504696500 335 GLNAQEIKLALPSMVLHapwMQDEPGEQPK 364
Cdd:COG3264  255 AFREEGIEIPFPQRDVH---LRNPPGEVPE 281
PRK10334 PRK10334
small-conductance mechanosensitive channel MscS;
144-290 3.47e-15

small-conductance mechanosensitive channel MscS;


Pssm-ID: 182386 [Multi-domain]  Cd Length: 286  Bit Score: 74.96  E-value: 3.47e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504696500 144 ILRAIVWSVMLLSILANAGVNITALVASLGVGGIAIALAVQTILSDVFASLSIGFDKPFEIGDFVVFNDVAGTVEHIGLK 223
Cdd:PRK10334  72 LVRYGIIAFTLIAALGRVGVQTASVIAVLGAAGLAVGLALQGSLSNLAAGVLLVMFRPFRAGEYVDLGGVAGTVLSVQIF 151
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 504696500 224 TTRIRSLSGEQIVCGNAILLQQTLHNYKRMQTRRIVFTFGVASDTPPDKlryvgdmVRQIITDVGET 290
Cdd:PRK10334 152 STTMRTADGKIIVIPNGKIIAGNIINFSREPVRRNEFIIGVAYDSDIDQ-------VKQILTNIIQS 211
PRK11465 PRK11465
putative mechanosensitive channel protein; Provisional
3-232 1.80e-07

putative mechanosensitive channel protein; Provisional


Pssm-ID: 183147 [Multi-domain]  Cd Length: 741  Bit Score: 52.86  E-value: 1.80e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504696500   3 FLSRFDI---IALMMTPTfwVGVATVVFVTLLVYWLLTRLIAfvkKGITTwgdkHPTTNRMRFILSDMLN-------RTS 72
Cdd:PRK11465 360 FFSLFDPgnsLKFMMGAT--VRSLAIIGIAAFVSGMFTRWIA---KTITL----SPHTQRNYPELQKRLNgwlsaalKTA 430
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504696500  73 RILLFVVALLFSLRFVDLPD--HLFGTVSHAWFLVFAIQVALWMDQGVVSW-----LRHVMLAPGSHKNPVT-------L 138
Cdd:PRK11465 431 RILTVCVAVMLLLNAWGLFDfwNWLQNGAGEKTVDILIRIALILFFSAVGWtvlasLIENRLASDIHGRPLPsartrtlL 510
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504696500 139 VITGLILRAIVWSVMLLSILANAGVNITALVASLGVGGIAIALAVQTILSDVFASLSIGFDKPFEIGDFVVFNDVAGTVE 218
Cdd:PRK11465 511 TLFRNALAVIISTITIMIVLSEIGVNIAPLLAGAGALGLAISFGSQTLVKDIITGVFIQFENGMNTGDLVTIGPLTGTVE 590
                        250
                 ....*....|....
gi 504696500 219 HIGLKTTRIRSLSG 232
Cdd:PRK11465 591 RMSIRSVGVRQDTG 604
PRK10929 PRK10929
putative mechanosensitive channel protein; Provisional
122-227 4.61e-05

putative mechanosensitive channel protein; Provisional


Pssm-ID: 236798 [Multi-domain]  Cd Length: 1109  Bit Score: 45.43  E-value: 4.61e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504696500  122 LRHVMLAPGSHKNPVTLVITGLILraiVWSVMLLSILANAGVNITALVASLGVGgiaIALAVQTILSDVFASLSIGFDKP 201
Cdd:PRK10929  862 LQHLDLTPGTGYAITTITKYLLML---IGGLVGFSMIGIEWSKLQWLVAALGVG---LGFGLQEIFANFISGLIILFEKP 935
                          90       100
                  ....*....|....*....|....*.
gi 504696500  202 FEIGDFVVFNDVAGTVEHIGLKTTRI 227
Cdd:PRK10929  936 IRIGDTVTIRDLTGSVTKINTRATTI 961
Stt3 COG1287
Asparagine N-glycosylation enzyme, membrane subunit Stt3 [Posttranslational modification, ...
74-229 3.54e-03

Asparagine N-glycosylation enzyme, membrane subunit Stt3 [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440898 [Multi-domain]  Cd Length: 774  Bit Score: 39.39  E-value: 3.54e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504696500  74 ILLFVVALLFSLRFVDLPDHLFGTVSHAWFLVFAIQVALWMDQGVVSWLRHVMLAPGshknPVTLVITGLILRAIvwsvm 153
Cdd:COG1287  230 LALFALLQLLLDLLRGRSPEYLAIVGAVSFAVAALLVLPFIPRLGFSGTGLSLLQPL----LALALAAGTVFLAW----- 300
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 504696500 154 LLSILANAGVNITALVASLGVGGIAIALAVQTILSDVFASLSIGFDkpfeigDFVVFNDVAGTV-EHIGLKTTRIRS 229
Cdd:COG1287  301 LARELERRDLPRLYYPAALVGLVAAGLALLAVLLPRVLAALIPGLR------RFFGASALAATIaEAQPLTLSDLFS 371
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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