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Conserved domains on  [gi|504697340|ref|WP_014884442|]
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MULTISPECIES: acyl carrier protein [Enterobacteriaceae]

Protein Classification

acyl carrier protein( domain architecture ID 10000754)

acyl carrier protein may function as a carrier of the growing fatty acid chain in fatty acid biosynthesis or as the carrier of activated (amino) acid groups in polyketide synthases and non-ribosomal peptide synthases

CATH:  1.10.1200.10
Gene Ontology:  GO:0009245|GO:0006633|GO:0000036|GO:0000035
PubMed:  18059524|30543875|20662770
SCOP:  4000857

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AcpP COG0236
Acyl carrier protein [Lipid transport and metabolism]; Acyl carrier protein is part of the ...
 4-86 1.73e-11

Acyl carrier protein [Lipid transport and metabolism]; Acyl carrier protein is part of the Pathway/BioSystem: Fatty acid biosynthesis


:

Pssm-ID: 440006 [Multi-domain]  Cd Length: 80  Bit Score: 54.47  E-value: 1.73e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697340  4 DMPVIVDRIKEIIAERigLDVEREDIADETGLASMVGMDSIGFVELRFQCEEEFNIKVEDKEFspANFYSCQTLSRFIMN 83
Cdd:COG0236   2 PREELEERLAEIIAEV--LGVDPEEITPDDSFFEDLGLDSLDAVELIAALEEEFGIELPDTEL--FEYPTVADLADYLEE 77


                ...
gi 504697340 84 KLG 86
Cdd:COG0236  78 KLA 80
 
Name Accession Description Interval E-value
AcpP COG0236
Acyl carrier protein [Lipid transport and metabolism]; Acyl carrier protein is part of the ...
 4-86 1.73e-11

Acyl carrier protein [Lipid transport and metabolism]; Acyl carrier protein is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440006 [Multi-domain]  Cd Length: 80  Bit Score: 54.47  E-value: 1.73e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697340  4 DMPVIVDRIKEIIAERigLDVEREDIADETGLASMVGMDSIGFVELRFQCEEEFNIKVEDKEFspANFYSCQTLSRFIMN 83
Cdd:COG0236   2 PREELEERLAEIIAEV--LGVDPEEITPDDSFFEDLGLDSLDAVELIAALEEEFGIELPDTEL--FEYPTVADLADYLEE 77


                ...
gi 504697340 84 KLG 86
Cdd:COG0236  78 KLA 80
PP-binding pfam00550
Phosphopantetheine attachment site; A 4'-phosphopantetheine prosthetic group is attached ...
 10-78 4.80e-09

Phosphopantetheine attachment site; A 4'-phosphopantetheine prosthetic group is attached through a serine. This prosthetic group acts as a a 'swinging arm' for the attachment of activated fatty acid and amino-acid groups. This domain forms a four helix bundle. This family includes members not included in Prosite. The inclusion of these members is supported by sequence analysis and functional evidence. The related domain of Swiss:P19828 has the attachment serine replaced by an alanine.


Pssm-ID: 425746 [Multi-domain]  Cd Length: 62  Bit Score: 47.56  E-value: 4.80e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 504697340  10 DRIKEIIAERIGLDVEreDIADETGLASMvGMDSIGFVELRFQCEEEFNIKVedkefSPANFYSCQTLS 78
Cdd:pfam00550  1 ERLRELLAEVLGVPAE--EIDPDTDLFDL-GLDSLLAVELIARLEEEFGVEI-----PPSDLFEHPTLA 61
acpP PRK00982
acyl carrier protein; Provisional
 5-65 6.92e-08

acyl carrier protein; Provisional


Pssm-ID: 179197 [Multi-domain]  Cd Length: 78  Bit Score: 45.16  E-value: 6.92e-08
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 504697340  5 MPVIVDRIKEIIAERigLDVEREDIADETGLASMVGMDSIGFVELRFQCEEEFNIKVEDKE 65
Cdd:PRK00982  1 MSEIFEKVKKIIVEQ--LGVDEEEVTPEASFVDDLGADSLDTVELVMALEEEFGIEIPDED 59
acyl_carrier TIGR00517
acyl carrier protein; This small protein has phosphopantetheine covalently bound to a Ser ...
 8-65 4.14e-06

acyl carrier protein; This small protein has phosphopantetheine covalently bound to a Ser residue. It acts as a carrier of the growing fatty acid chain, which is bound to the prosthetic group, during fatty acid biosynthesis. Homologous phosphopantetheine-binding domains are found in longer proteins. Acyl carrier proteins scoring above the noise cutoff but below the trusted cutoff may be specialized versions. These include those involved in mycolic acid biosynthesis in the Mycobacteria, lipid A biosynthesis in Rhizobium, actinorhodin polyketide synthesis in Streptomyces coelicolor, etc. This protein is not found in the Archaea.Gene name acpP.S (Ser) at position 37 in the seed alignment, in the motif DSLD, is the phosphopantetheine attachment site. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 213536 [Multi-domain]  Cd Length: 77  Bit Score: 40.46  E-value: 4.14e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 504697340   8 IVDRIKEIIAERigLDVEREDIADETGLASMVGMDSIGFVELRFQCEEEFNIKVEDKE 65
Cdd:TIGR00517  4 IFEKVKAIIKEQ--LNVDEDQITTDARFVEDLGADSLDTVELVMALEEEFDIEIPDEE 59
PKS_PP smart00823
Phosphopantetheine attachment site; Phosphopantetheine (or pantetheine 4' phosphate) is the ...
 7-85 1.98e-04

Phosphopantetheine attachment site; Phosphopantetheine (or pantetheine 4' phosphate) is the prosthetic group of acyl carrier proteins (ACP) in some multienzyme complexes where it serves as a 'swinging arm' for the attachment of activated fatty acid and amino-acid groups.


Pssm-ID: 214834 [Multi-domain]  Cd Length: 86  Bit Score: 36.46  E-value: 1.98e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697340    7 VIVDRIKEIIAERIGLDVErEDIADETGLASMvGMDSIGFVELRFQCEEEFNIKVedkefSPANFYSCQT---LSRFIMN 83
Cdd:smart00823 12 LLLDLVREQVAAVLGHAAA-EAIDPDRPFRDL-GLDSLMAVELRNRLEAATGLRL-----PATLVFDHPTpaaLAEHLAA 84


                  ..
gi 504697340   84 KL 85
Cdd:smart00823 85 EL 86
 
Name Accession Description Interval E-value
AcpP COG0236
Acyl carrier protein [Lipid transport and metabolism]; Acyl carrier protein is part of the ...
 4-86 1.73e-11

Acyl carrier protein [Lipid transport and metabolism]; Acyl carrier protein is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440006 [Multi-domain]  Cd Length: 80  Bit Score: 54.47  E-value: 1.73e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697340  4 DMPVIVDRIKEIIAERigLDVEREDIADETGLASMVGMDSIGFVELRFQCEEEFNIKVEDKEFspANFYSCQTLSRFIMN 83
Cdd:COG0236   2 PREELEERLAEIIAEV--LGVDPEEITPDDSFFEDLGLDSLDAVELIAALEEEFGIELPDTEL--FEYPTVADLADYLEE 77


                ...
gi 504697340 84 KLG 86
Cdd:COG0236  78 KLA 80
PP-binding pfam00550
Phosphopantetheine attachment site; A 4'-phosphopantetheine prosthetic group is attached ...
 10-78 4.80e-09

Phosphopantetheine attachment site; A 4'-phosphopantetheine prosthetic group is attached through a serine. This prosthetic group acts as a a 'swinging arm' for the attachment of activated fatty acid and amino-acid groups. This domain forms a four helix bundle. This family includes members not included in Prosite. The inclusion of these members is supported by sequence analysis and functional evidence. The related domain of Swiss:P19828 has the attachment serine replaced by an alanine.


Pssm-ID: 425746 [Multi-domain]  Cd Length: 62  Bit Score: 47.56  E-value: 4.80e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 504697340  10 DRIKEIIAERIGLDVEreDIADETGLASMvGMDSIGFVELRFQCEEEFNIKVedkefSPANFYSCQTLS 78
Cdd:pfam00550  1 ERLRELLAEVLGVPAE--EIDPDTDLFDL-GLDSLLAVELIARLEEEFGVEI-----PPSDLFEHPTLA 61
acpP PRK00982
acyl carrier protein; Provisional
 5-65 6.92e-08

acyl carrier protein; Provisional


Pssm-ID: 179197 [Multi-domain]  Cd Length: 78  Bit Score: 45.16  E-value: 6.92e-08
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 504697340  5 MPVIVDRIKEIIAERigLDVEREDIADETGLASMVGMDSIGFVELRFQCEEEFNIKVEDKE 65
Cdd:PRK00982  1 MSEIFEKVKKIIVEQ--LGVDEEEVTPEASFVDDLGADSLDTVELVMALEEEFGIEIPDED 59
acpP CHL00124
acyl carrier protein; Validated
 4-63 1.77e-06

acyl carrier protein; Validated


Pssm-ID: 177047 [Multi-domain]  Cd Length: 82  Bit Score: 41.54  E-value: 1.77e-06
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697340  4 DMPVIVDRIKEIIAERIGldVEREDIADETGLASMVGMDSIGFVELRFQCEEEFNIKVED 63
Cdd:CHL00124  2 TKNDIFEKVQSIVAEQLG--IEKSEVTLDANFTRDLGADSLDVVELVMAIEEKFDIEIPD 59
acyl_carrier TIGR00517
acyl carrier protein; This small protein has phosphopantetheine covalently bound to a Ser ...
 8-65 4.14e-06

acyl carrier protein; This small protein has phosphopantetheine covalently bound to a Ser residue. It acts as a carrier of the growing fatty acid chain, which is bound to the prosthetic group, during fatty acid biosynthesis. Homologous phosphopantetheine-binding domains are found in longer proteins. Acyl carrier proteins scoring above the noise cutoff but below the trusted cutoff may be specialized versions. These include those involved in mycolic acid biosynthesis in the Mycobacteria, lipid A biosynthesis in Rhizobium, actinorhodin polyketide synthesis in Streptomyces coelicolor, etc. This protein is not found in the Archaea.Gene name acpP.S (Ser) at position 37 in the seed alignment, in the motif DSLD, is the phosphopantetheine attachment site. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 213536 [Multi-domain]  Cd Length: 77  Bit Score: 40.46  E-value: 4.14e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 504697340   8 IVDRIKEIIAERigLDVEREDIADETGLASMVGMDSIGFVELRFQCEEEFNIKVEDKE 65
Cdd:TIGR00517  4 IFEKVKAIIKEQ--LNVDEDQITTDARFVEDLGADSLDTVELVMALEEEFDIEIPDEE 59
PTZ00171 PTZ00171
acyl carrier protein; Provisional
 8-81 5.58e-05

acyl carrier protein; Provisional


Pssm-ID: 240304  Cd Length: 148  Bit Score: 38.91  E-value: 5.58e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 504697340   8 IVDRIKEIIAERigLDVEREDIADETGLASMVGMDSIGFVELRFQCEEEFNIKVEDKEFSpaNFYSCQTLSRFI 81
Cdd:PTZ00171  71 VLTRVKKVVKNF--EKVDASKITPESNFVKDLGADSLDVVELLIAIEQEFNLTIPDHDAE--KIKTVQDAIDYI 140
PKS_PP smart00823
Phosphopantetheine attachment site; Phosphopantetheine (or pantetheine 4' phosphate) is the ...
 7-85 1.98e-04

Phosphopantetheine attachment site; Phosphopantetheine (or pantetheine 4' phosphate) is the prosthetic group of acyl carrier proteins (ACP) in some multienzyme complexes where it serves as a 'swinging arm' for the attachment of activated fatty acid and amino-acid groups.


Pssm-ID: 214834 [Multi-domain]  Cd Length: 86  Bit Score: 36.46  E-value: 1.98e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697340    7 VIVDRIKEIIAERIGLDVErEDIADETGLASMvGMDSIGFVELRFQCEEEFNIKVedkefSPANFYSCQT---LSRFIMN 83
Cdd:smart00823 12 LLLDLVREQVAAVLGHAAA-EAIDPDRPFRDL-GLDSLMAVELRNRLEAATGLRL-----PATLVFDHPTpaaLAEHLAA 84


                  ..
gi 504697340   84 KL 85
Cdd:smart00823 85 EL 86
PRK07081 PRK07081
acyl carrier protein; Provisional
 12-81 2.47e-03

acyl carrier protein; Provisional


Pssm-ID: 180828  Cd Length: 83  Bit Score: 33.39  E-value: 2.47e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697340 12 IKEIIAERIGLDVEREDIADETGLASmVGMDSIGFVELRFQCEEEFNIKVEDKEFSPANFYSCQTLSRFI 81
Cdd:PRK07081  5 IRTILKKVAKLEVPIDSIADDADLYE-AGLSSLATVQLMLAIEDAFDIEIPDEMLNRKLFASIDALAGAV 73
PRK08417 PRK08417
metal-dependent hydrolase;
11-76 7.15e-03

metal-dependent hydrolase;


Pssm-ID: 236262 [Multi-domain]  Cd Length: 386  Bit Score: 33.52  E-value: 7.15e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 504697340  11 RIKEIIAERIGLDVEREDIADETGLASMVGMdsigfVELrfqceeefNIKVEDKEFSPANFYSCQT 76
Cdd:PRK08417   2 RIKDGKITEIGSDLKGEEILDAKGKTLLPAL-----VDL--------NVSLKNDSLSSKNLKSLEN 54
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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