NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|504697632|ref|WP_014884734|]
View 

MULTISPECIES: bile acid:sodium symporter family protein [Enterobacter]

Protein Classification

bile acid:sodium symporter family protein( domain architecture ID 10612733)

bile acid:sodium symporter (BASS) family protein, similar to fungal olute carrier RCH1, an influx transporter that may be involved in cytosolic calcium homeostasis

Gene Ontology:  GO:0015293|GO:0006810|GO:0016020
PubMed:  23506869|23177985
TCDB:  2.A.28

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
SBF_like pfam13593
SBF-like CPA transporter family (DUF4137); These family members are 7TM putative membrane ...
8-316 9.16e-108

SBF-like CPA transporter family (DUF4137); These family members are 7TM putative membrane transporter proteins. The family is similar to the SBF family of bile-acid symporters, pfam01758.


:

Pssm-ID: 433336  Cd Length: 313  Bit Score: 316.83  E-value: 9.16e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697632    8 DPFTLTLVVTVLLASFFPARGGFVPFF--EGLTTAAIALLFFMHGAKLSREAIIAGGGHWRLHLWVMCSTFILFPILGVL 85
Cdd:pfam13593   1 QWFLLGLVLAILLASLLPVFGAAGGPIraEYVITYGVALIFFLSGLRLSTEELLAGLRNWRLHLFVQLFTFVLFPLLGLG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697632   86 FAWWAPVNVDPALYTGFLYLCILPATVQSAIAFTSLAGGNVAAAVCSASASSLLGIFVSPLLVGLLMNMHGAEGNLEQV- 164
Cdd:pfam13593  81 LSSLLPAALPPELLIGFLLLAALPTTVSSSVAMTSQAGGNVAAAVCNASIGNLLGVFLTPALVGLLLGGGGAGIDYGAVl 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697632  165 GRICLQLLLPFVLGHLSRPWTGAFVTKHKKWISKTDQTSILLVVYSAFSEAVVNGIWHKVGAGSLLFIVVVSIVLLAIVI 244
Cdd:pfam13593 161 KKLGLQVLLPLVLGQLLRPWFPKWTKRHKKLLKKVDSGVILLIVYTSFSTAFVQGAFHSVSHSILLVIFNVGLYLLAVVL 240
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 504697632  245 AVNVFVARKCGFNKADEITIVFCGSKKSLANGIPMANILFPT-SVIGMMVLPLMIFHQIQLMVCAVLARRYKR 316
Cdd:pfam13593 241 GATWFLARLLGFSREDEIAILFCGSKKSLALGVPLASVLFGGnPQLGLILLPLLLYHQIQLMVCSVLAPRLAR 313
 
Name Accession Description Interval E-value
SBF_like pfam13593
SBF-like CPA transporter family (DUF4137); These family members are 7TM putative membrane ...
8-316 9.16e-108

SBF-like CPA transporter family (DUF4137); These family members are 7TM putative membrane transporter proteins. The family is similar to the SBF family of bile-acid symporters, pfam01758.


Pssm-ID: 433336  Cd Length: 313  Bit Score: 316.83  E-value: 9.16e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697632    8 DPFTLTLVVTVLLASFFPARGGFVPFF--EGLTTAAIALLFFMHGAKLSREAIIAGGGHWRLHLWVMCSTFILFPILGVL 85
Cdd:pfam13593   1 QWFLLGLVLAILLASLLPVFGAAGGPIraEYVITYGVALIFFLSGLRLSTEELLAGLRNWRLHLFVQLFTFVLFPLLGLG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697632   86 FAWWAPVNVDPALYTGFLYLCILPATVQSAIAFTSLAGGNVAAAVCSASASSLLGIFVSPLLVGLLMNMHGAEGNLEQV- 164
Cdd:pfam13593  81 LSSLLPAALPPELLIGFLLLAALPTTVSSSVAMTSQAGGNVAAAVCNASIGNLLGVFLTPALVGLLLGGGGAGIDYGAVl 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697632  165 GRICLQLLLPFVLGHLSRPWTGAFVTKHKKWISKTDQTSILLVVYSAFSEAVVNGIWHKVGAGSLLFIVVVSIVLLAIVI 244
Cdd:pfam13593 161 KKLGLQVLLPLVLGQLLRPWFPKWTKRHKKLLKKVDSGVILLIVYTSFSTAFVQGAFHSVSHSILLVIFNVGLYLLAVVL 240
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 504697632  245 AVNVFVARKCGFNKADEITIVFCGSKKSLANGIPMANILFPT-SVIGMMVLPLMIFHQIQLMVCAVLARRYKR 316
Cdd:pfam13593 241 GATWFLARLLGFSREDEIAILFCGSKKSLALGVPLASVLFGGnPQLGLILLPLLLYHQIQLMVCSVLAPRLAR 313
YfeH COG0385
Predicted Na+-dependent transporter YfeH [General function prediction only];
8-318 6.29e-70

Predicted Na+-dependent transporter YfeH [General function prediction only];


Pssm-ID: 440154  Cd Length: 294  Bit Score: 219.64  E-value: 6.29e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697632   8 DPFTLTLVVTVLLASFFPArggfvpFFEGLTTAAIALLFFMHGAKLSREAIIAGGGHWRLHLWVMCSTFILFPILGVLFA 87
Cdd:COG0385    1 DWFLLLLLLAVVLALLLPA------AFEPLLPLLLALIMFGMGLTLSPEDFKRVLRRPRLVLLGLLAQFVLMPLLALALA 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697632  88 WWapVNVDPALYTGFLYLCILPATVQSAIaFTSLAGGNVAAAVCSASASSLLGIFVSPLLVGLLMNMHGAEGN-LEQVGR 166
Cdd:COG0385   75 LL--FGLPPELALGLLLLAACPGGVASNV-FTSLARGNVALSVSLTAVSTLLAPFLTPLLVALLLGLQGVEVDpLDMILS 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697632 167 ICLQLLLPFVLGHLSRPWTGAFVTKHKKWISKTDQTSILLVVYSAFSEAVVNGiwhkvgAGSLLFIVVVSIVLLAIVIAV 246
Cdd:COG0385  152 LLLIVLLPLVLGMLLRRLLPKWAERLKKPLPLVSRLAILLIVYAAFAANVDNL------LSVGLLVLLAVLLLNALGLLL 225
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 504697632 247 NVFVARKCGFNKADEITIVFCGSKKSLANGIPMANILFPTsviGMMVLPLMIFHQIQLMVCAVLARRYKRQT 318
Cdd:COG0385  226 GYLLARLLGLDRADRITIAFEVGMKNLGLALVLATTLFPG---PLAALPAALYHLWQLIVGALLARRWARRA 294
 
Name Accession Description Interval E-value
SBF_like pfam13593
SBF-like CPA transporter family (DUF4137); These family members are 7TM putative membrane ...
8-316 9.16e-108

SBF-like CPA transporter family (DUF4137); These family members are 7TM putative membrane transporter proteins. The family is similar to the SBF family of bile-acid symporters, pfam01758.


Pssm-ID: 433336  Cd Length: 313  Bit Score: 316.83  E-value: 9.16e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697632    8 DPFTLTLVVTVLLASFFPARGGFVPFF--EGLTTAAIALLFFMHGAKLSREAIIAGGGHWRLHLWVMCSTFILFPILGVL 85
Cdd:pfam13593   1 QWFLLGLVLAILLASLLPVFGAAGGPIraEYVITYGVALIFFLSGLRLSTEELLAGLRNWRLHLFVQLFTFVLFPLLGLG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697632   86 FAWWAPVNVDPALYTGFLYLCILPATVQSAIAFTSLAGGNVAAAVCSASASSLLGIFVSPLLVGLLMNMHGAEGNLEQV- 164
Cdd:pfam13593  81 LSSLLPAALPPELLIGFLLLAALPTTVSSSVAMTSQAGGNVAAAVCNASIGNLLGVFLTPALVGLLLGGGGAGIDYGAVl 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697632  165 GRICLQLLLPFVLGHLSRPWTGAFVTKHKKWISKTDQTSILLVVYSAFSEAVVNGIWHKVGAGSLLFIVVVSIVLLAIVI 244
Cdd:pfam13593 161 KKLGLQVLLPLVLGQLLRPWFPKWTKRHKKLLKKVDSGVILLIVYTSFSTAFVQGAFHSVSHSILLVIFNVGLYLLAVVL 240
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 504697632  245 AVNVFVARKCGFNKADEITIVFCGSKKSLANGIPMANILFPT-SVIGMMVLPLMIFHQIQLMVCAVLARRYKR 316
Cdd:pfam13593 241 GATWFLARLLGFSREDEIAILFCGSKKSLALGVPLASVLFGGnPQLGLILLPLLLYHQIQLMVCSVLAPRLAR 313
YfeH COG0385
Predicted Na+-dependent transporter YfeH [General function prediction only];
8-318 6.29e-70

Predicted Na+-dependent transporter YfeH [General function prediction only];


Pssm-ID: 440154  Cd Length: 294  Bit Score: 219.64  E-value: 6.29e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697632   8 DPFTLTLVVTVLLASFFPArggfvpFFEGLTTAAIALLFFMHGAKLSREAIIAGGGHWRLHLWVMCSTFILFPILGVLFA 87
Cdd:COG0385    1 DWFLLLLLLAVVLALLLPA------AFEPLLPLLLALIMFGMGLTLSPEDFKRVLRRPRLVLLGLLAQFVLMPLLALALA 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697632  88 WWapVNVDPALYTGFLYLCILPATVQSAIaFTSLAGGNVAAAVCSASASSLLGIFVSPLLVGLLMNMHGAEGN-LEQVGR 166
Cdd:COG0385   75 LL--FGLPPELALGLLLLAACPGGVASNV-FTSLARGNVALSVSLTAVSTLLAPFLTPLLVALLLGLQGVEVDpLDMILS 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697632 167 ICLQLLLPFVLGHLSRPWTGAFVTKHKKWISKTDQTSILLVVYSAFSEAVVNGiwhkvgAGSLLFIVVVSIVLLAIVIAV 246
Cdd:COG0385  152 LLLIVLLPLVLGMLLRRLLPKWAERLKKPLPLVSRLAILLIVYAAFAANVDNL------LSVGLLVLLAVLLLNALGLLL 225
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 504697632 247 NVFVARKCGFNKADEITIVFCGSKKSLANGIPMANILFPTsviGMMVLPLMIFHQIQLMVCAVLARRYKRQT 318
Cdd:COG0385  226 GYLLARLLGLDRADRITIAFEVGMKNLGLALVLATTLFPG---PLAALPAALYHLWQLIVGALLARRWARRA 294
ACR3 COG0798
Arsenite efflux pump ArsB, ACR3 family [Inorganic ion transport and metabolism];
23-299 3.42e-07

Arsenite efflux pump ArsB, ACR3 family [Inorganic ion transport and metabolism];


Pssm-ID: 440561  Cd Length: 335  Bit Score: 51.28  E-value: 3.42e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697632  23 FFPARGGFVPFFEGLTTA---AIALLFFMHG--AKLSREAIIAGGGHWRLHLWVMCSTFILFPILGVLFAWWApVNVDPA 97
Cdd:COG0798   29 LFPGVFQALASLEVATVNipiAILLWLMIYPmmAKVDFEELGKVFRNPKGLGLTLVINWLIKPFLMFALAWLF-LPDAPE 107
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697632  98 LYTGFLYLCILPATVQsAIAFTSLAGGNVAAAVCSASASSLLGIFVSPLLVGLLMNMHGAEGNLEQVGR-ICLQLLLPFV 176
Cdd:COG0798  108 YIAGLILLGLAPCTAM-VIVWTGLAKGDVEYALVLVALNLLLQVLLFPPYVWLLLGVSDVTVPWGTLALsVLLYVVIPLA 186
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697632 177 LGHLSRPW------TGAFVTKHKKWISKTDQTSILLVVYSAFS---EAVVNGIWHkvgagsLLFIVVVSIVLLAIVIAVN 247
Cdd:COG0798  187 AGFLTRRLllrrkgREWFEERFLPKLSPISLLGLLLTIVLLFAlqgETILENPLD------ILLIAIPLLIQFAINFALS 260
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697632 248 VFVARKCGFNKADEITIVFCGSKKSLANGIPMANILFPTS-------VIGMMV-LPLMIF 299
Cdd:COG0798  261 YLLGRLLGLPYEDAAPLAFTGASNNFELALAVAIALFGLNsgaalatVVGPLIeVPVMLS 320
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH