|
Name |
Accession |
Description |
Interval |
E-value |
| AlaS |
COG0013 |
Alanyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Alanyl-tRNA ... |
3-875 |
0e+00 |
|
Alanyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Alanyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439784 [Multi-domain] Cd Length: 880 Bit Score: 1621.28 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697874 3 KSTAEIRQAFLDFFHSKGHQVVASSSLVPNNDPTLLFTNAGMNQFKDVFLGLDKRNYSRATTSQRCVRAGGKHNDLENVG 82
Cdd:COG0013 2 MTSAEIRQKFLDFFESKGHTIVPSSSLVPKNDPTLLFTNAGMVQFKPYFLGQEKPPYPRATTSQKCVRTGGKHNDLENVG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697874 83 YTARHHTFFEMLGNFSFGDYFKHDAIQYAWELLTgeNWFNLPKERLWVTVYETDDEAYEIWEKEVGIPRERIIRIGdnkg 162
Cdd:COG0013 82 YTARHHTFFEMLGNFSFGDYFKEEAIAWAWELLT--EVLGLPKERLWVTVYEDDDEAYDIWKKEIGVPEERIIRLG---- 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697874 163 apyASDNFWQMGDTGPCGPCTEIFYDHGDHIWGGPPGSPEEDGDRYIEIWNIVFMQFNRQADGTMEPLPKPSVDTGMGLE 242
Cdd:COG0013 156 ---KKDNFWEMGDTGPCGPCSEIFYDRGPEYGGGPPGSPGEDGDRYIEIWNLVFMQFNRDEDGTLTPLPKKNIDTGMGLE 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697874 243 RIAAVLQHVNSNYEIDLFSTLIKAVAEVTGAT----DLNNKSLRVIADHIRSCAFLIADGVIPSNENRGYVLrriirrai 318
Cdd:COG0013 233 RIAAVLQGVHSNYETDLFRPLIEAAAELTGVKygadEEDDVSLRVIADHIRAVAFLIADGVLPSNEGRGYVLrrilrrav 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697874 319 rHGNMLGAKDTFFYKLVGPLIGVMGAAGDELKRQQAQVEQVLKTEEEQFARTLERGLALLDEELAKLK---GDTLDGETA 395
Cdd:COG0013 313 rHGRLLGIKEPFLYKLVPVVVEEMGDAYPELKEKQELIEKVLKAEEERFLRTLERGLKLLDEAIAKLKaagGKVLSGEDA 392
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697874 396 FRLYDTYGFPVDLTADVCRERNIKVDEVGFEAAMEEQRRRARESSGFGADYNA------MIRVDSASEFKGYDALELTGK 469
Cdd:COG0013 393 FKLYDTYGFPLDLTEEIARERGLTVDEEGFEAAMEEQRERARAAAKFSGDAAVdgvwreLLEEGGPTEFVGYDTLEAEAK 472
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697874 470 VTALFVDGKAVDSISAGQDAVVILDKTPFYAESGGQVGDKGELKGNGFSFSVSDTQK-FGQAIGHQGKLVSGSLKVGEGV 548
Cdd:COG0013 473 VLALVKDGELVDSAKAGEEVEVVLDRTPFYAESGGQVGDTGTIEGDGGVFEVTDTQKpPGGLIVHIGKVEEGELKVGDTV 552
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697874 549 QANVDEARRARIRLNHSATHLMHAALRDVLGTHVAQKGSLVNDKVLRFDFSHFEAMKPSEIRAVEDLVNAQIRRNLPIET 628
Cdd:COG0013 553 TAQVDAERRRAIARNHSATHLLHAALREVLGEHVTQAGSLVAPDRLRFDFSHFEALTPEELAEIEDLVNEKIRENLPVET 632
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697874 629 HIMDLEDAKKKGAMALFGEKYDERVRVLSMGDFSTELCGGTHASRTGDIGLFRIVSESGTAAGVRRIEAVTGEGAIASLH 708
Cdd:COG0013 633 REMPLDEAKALGAMALFGEKYGDEVRVVSIGDFSRELCGGTHVSRTGDIGLFKIVSESSVAAGVRRIEAVTGEAALEYLR 712
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697874 709 AQSDQLHDIAQLLKGDSQNLGEKVRVALERTRQLEKELQQLKEQAAAQESANLSSKAVDIKGVKLLVSDLAGVEPKMLRT 788
Cdd:COG0013 713 EQEALLKELAELLKAPPEELPERVEALLEELKELEKELEQLKAKLASAAADDLLAQAEEIGGVKVLAARVEGVDAKDLRD 792
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697874 789 MVDDLKNQLGSTVIVLATVAEGKVSLIAGVSKDVTDR-VKAGELIGMVAQQVGGKGGGRPDMAQAGGTDAAALPQALASV 867
Cdd:COG0013 793 LADDLKDKLGSGVVVLASVADGKVSLVAGVTKDLVKKgLKAGDLVKEVAKIVGGGGGGRPDMAQAGGKDPSKLDEALAAV 872
|
....*...
gi 504697874 868 ESWVSAKL 875
Cdd:COG0013 873 KEWLAEKL 880
|
|
| alaS |
TIGR00344 |
alanine--tRNA ligase; The model describes alanine--tRNA ligase. This enzyme catalyzes the ... |
7-854 |
0e+00 |
|
alanine--tRNA ligase; The model describes alanine--tRNA ligase. This enzyme catalyzes the reaction (tRNAala + L-alanine + ATP = L-alanyl-tRNAala + pyrophosphate + AMP). [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273026 [Multi-domain] Cd Length: 845 Bit Score: 1234.17 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697874 7 EIRQAFLDFFHSKGHQVVASSSLVPNNDPTLLFTNAGMNQFKDVFLGLDKRNYSRATTSQRCVRAggkhNDLENVGYTAR 86
Cdd:TIGR00344 1 EIRQTFLDFFKEKGHQVIPSAPLVPRNDPTLLLTNAGMAQFKPIFTGIVKPPSNRLTNAQPCIRL----NDLENVGRTAR 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697874 87 HHTFFEMLGNFSFGDYFKHDAIQYAWELLTgeNWFNLPKERLWVTVYETDDEAYEIWEKevgiprerIIRIGDNKGAPYA 166
Cdd:TIGR00344 77 HHTLFEMLGNFSFGDYFKEEAIAFAWELLT--EVLGLDKERLYVTVYEDDEEAYKIWEK--------IGIPADRIIKCDA 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697874 167 SDNFWQMGDtGPCGPCTEIFYDHgdhiWGGPPGSPEEDGDRYIEIWNIVFMQFNRQADGTMEPLPKPSVDTGMGLERIAA 246
Cdd:TIGR00344 147 KDNFWDMGD-GPCGPCTEIYYDF----VGGKPGEPLEENDRYLEVWNLVFMQFNRDPDGNYTPLPKKNIDTGMGLERFVA 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697874 247 VLQHVNSNYEIDLFSTLIKAVAEVTGATDLNNK-------------SLRVIADHIRSCAFLIADGVIPSNENRGYVLRRI 313
Cdd:TIGR00344 222 VLQGVPTNYDTDIFLPLIEKIEEITGVKYDSNNagimdekrvedlrSLRVIADHTRAIAFMLADGVVPSNEGRGYVLRRL 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697874 314 IRRAIRHGNMLGAKDTFFYKLVGPLIGVMGAAGDELKRQQAQVEQVLKTEEEQFARTLERGLALLDEELAKLKGDTLDGE 393
Cdd:TIGR00344 302 IRRALRHGKKLGLKEAFLYKLVPTLIEVLGDYYPELKEKQEFVEQILELEEERFAKTLERGLRLFEKLLKKTGKKELDGE 381
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697874 394 TAFRLYDTYGFPVDLTADVCRERNIKVDEVGFEAAMEEQRRRARESSGFGADYNAMIRVDSASEFKGYDALELTGKVTAL 473
Cdd:TIGR00344 382 DAFKLYDTYGFPVELTKEIAEERGLTVDMPGFEALMAEQRERSKQNSQFQEQEIALVNVYPATEFLGYDDLEFEAKVIGL 461
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697874 474 FVDGKAVDSISAGQDAVVILDKTPFYAESGGQVGDKGELKGNGFSFSVSDTQKFGQAIGHQGKLVSGSLKVGEGVQANVD 553
Cdd:TIGR00344 462 FDDGYLVEQALAGQSVYVILDQTPFYAESGGQIGDTGYLIANDGKFRVVDVQKPNGVVFHFGEVEGGSLKVGDKVIAVID 541
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697874 554 EARRARIRLNHSATHLMHAALRDVLGTHVAQKGSLVNDKVLRFDFSHFEAMKPSEIRAVEDLVNAQIRRNLPIETHIMDL 633
Cdd:TIGR00344 542 EKRRFRIMRNHSATHLLHAALQKVLGNHVWQAGSLVSFKKLRFDFSHFRALTREELEEIEDLANEQILANIPIKVIFMDL 621
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697874 634 EDAKKKGAMALFGEKY--DERVRVLSMGDFSTELCGGTHASRTGDIGLFRIVSESGTAAGVRRIEAVTGEGAIASLHAQS 711
Cdd:TIGR00344 622 DEAKRKGAFALFGEKYvpGEKVRVVSVGDFSVELCGGTHVRNTGEIGLFKIVKESGIAAGVRRIEAVTGEAAIEYLNEQE 701
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697874 712 DQLHDIAQLLKGDSQNLGEKVRVALERTRQLEKELQQLKEQAAAQESANLSSKAVDIKGVKLLVSDLAGVEPKMLRTMVD 791
Cdd:TIGR00344 702 DKLKELADILKVTPNELPKKVERFFEEWKALQKELESLKLKIADQKIDELKDKAETINGVKVLVEVVDAKDMKSLKTMAD 781
|
810 820 830 840 850 860
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 504697874 792 DLKNQLGSTVIVLATVAEGKVSLIAGVSKDV-TDRVKAGELIGMVAQQVGGKGGGRPDMAQAGG 854
Cdd:TIGR00344 782 RLKSKLGSAIYVLASFAEGKVKLVCGVSNDVlTKKIKAGELINQIAQVLGGKGGGRPDFAQGGG 845
|
|
| PLN02900 |
PLN02900 |
alanyl-tRNA synthetase |
4-873 |
0e+00 |
|
alanyl-tRNA synthetase
Pssm-ID: 215487 [Multi-domain] Cd Length: 936 Bit Score: 991.82 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697874 4 STAEIRQAFLDFFHSKGHQVVASSSLVPNNDPTLLFTNAGMNQFKDVFLG-----LDKRNYSRATTSQRCVRAGGKHNDL 78
Cdd:PLN02900 12 PGDRIRRTFLSFFESKGHTFLPSSPLVPVDDPTLLFTNAGMNQFKPIFLGtadpnTPLRKLPRATNTQKCIRAGGKHNDL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697874 79 ENVGYTARHHTFFEMLGNFSFGDYFKHDAIQYAWELLTGEnwFNLPKERLWVTVYETDD------EAYEIWEKEVgiPRE 152
Cdd:PLN02900 92 DDVGKDTYHHTFFEMLGNWSFGDYFKKEAIGWAWELLTKV--YGLPADRLYATYFGGDEkqapddEARAIWLDYL--PEE 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697874 153 RIIRIGdnkgapyASDNFWQMGDTGPCGPCTEIFYD-HGDHiwgGPPGSPEEDGDRYIEIWNIVFMQFNRQADGTMEPLP 231
Cdd:PLN02900 168 RVLPFG-------CKDNFWEMGDTGPCGPCSEIHYDrIGER---DAADLVNNDDPRFIEIWNLVFIQFNREADGSLKPLP 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697874 232 KPSVDTGMGLERIAAVLQHVNSNYEIDLFSTLIKAVAEVTGATDLNNKS-----------LRVIADHIRSCAFLIADGVI 300
Cdd:PLN02900 238 AKHVDTGMGLERLASILQNKPSNYDTDLFMPIFDAIQEATGARPYAGKVgaedddrvdmaYRVVADHIRTLSFAIADGVV 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697874 301 PSNENRGYVLRRIIRRAIRHGN-MLGAKDTFFYKLVGPLIGVMGAAGDELKRQQAQVEQVLKTEEEQFARTLERGLALLD 379
Cdd:PLN02900 318 PSNEGRGYVLRRLLRRAVRYGRlLLGAEEGFFPALVEVVVELSGDVFPEVKKNEKRITEIIAEEELSFGKTLEKGIEKFK 397
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697874 380 EELAKLK---GDTLDGETAFRLYDTYGFPVDLTADVCRERNIKVDEVGFEAAMEEQRRRARESsGFGADYNAMIRVDSAS 456
Cdd:PLN02900 398 KALAAAKangGPVLSGKDAFLLYDTYGFPVDLTELMAEERGVTVDMEGFEAAMEEARERSRAA-HLKAGGGAIELAAEAT 476
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697874 457 ------------EFKGYDALE-LTGKVTALFVDGKAVDSISAGQDAVVILDKTPFYAESGGQVGDKGELKG-NGFSFSVS 522
Cdd:PLN02900 477 swlqkqgvaatdDFLKYDWLSdHEAVVKAILTGGGFVESVSEGDEVGIVLDKTSFYAESGGQIGDTGVLEGsGGAVVEVS 556
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697874 523 DTQKFGQAIGHQGKLVSGSLKVGEGVQANVDEARRARIRLNHSATHLMHAALRDVLGTHVAQKGSLVNDKVLRFDFSHFE 602
Cdd:PLN02900 557 DVQKAGGFVLHIGTVTEGSVSVGDAVTCKVDYDRRRRIAPNHTATHLLNSALKEVLGDHVDQKGSLVAFEKLRFDFSHGK 636
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697874 603 AMKPSEIRAVEDLVNAQIRRNLPIETHIMDLEDAKK-KGAMALFGEKYDERVRVLSMGD-FSTELCGGTHASRTGDIGLF 680
Cdd:PLN02900 637 PMTPEELREVESLVNEWIGDALPVEAKEMPLADAKRiNGLRAVFGEKYPDPVRVVSVGGvYSMELCGGTHVSNTAEAEAF 716
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697874 681 RIVSESGTAAGVRRIEAVTGEGAIASLHAQSDQLHDIAQLLKGDSQNLGEKV----------------------RVA--L 736
Cdd:PLN02900 717 KLLSEEGIAKGIRRITAVTGGAAVEAINAADSLERELDSALKVEGSDLEKKVaslksrvdaavipaakkeeiraRVSalQ 796
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697874 737 ERTRQLEKELQQLKEQAAAQESANLSSKAVDIkGVKLLVSDLA-GVEPKMLRTMVDDLKNQLGSTVIVLATVAE--GKVS 813
Cdd:PLN02900 797 KELRAAQKEAAALRAKLAVAKATELASKALSA-GKSVLVARLDvGVDAAALKEAAEKVIAKLGDPAAVVLSSDEekGKVS 875
|
890 900 910 920 930 940
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 504697874 814 LIAGVSKDVTD-RVKAGELIGMVAQQVGGKGGGRPDMAQAGGTDAAALPQALASVESWVSA 873
Cdd:PLN02900 876 LVAAVPPGVVKkGLKAGKWLGAIAKLCGGGGGGKPGFAQGQGRDAEKLDAALEKARAFAVA 936
|
|
| tRNA-synt_2c |
pfam01411 |
tRNA synthetases class II (A); Other tRNA synthetase sub-families are too dissimilar to be ... |
7-556 |
0e+00 |
|
tRNA synthetases class II (A); Other tRNA synthetase sub-families are too dissimilar to be included. This family includes only alanyl-tRNA synthetases.
Pssm-ID: 279719 [Multi-domain] Cd Length: 548 Bit Score: 841.94 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697874 7 EIRQAFLDFFHSKGHQVVASSSLVPNNDPTLLFTNAGMNQFKDVFLGL-DKRNYSRATTSQRCVRAGgkhnDLENVGYTA 85
Cdd:pfam01411 1 EIRQTFLDFFEKKGHTRVPSSPVVPRNDPTLLFTNAGMNQFKPIFLGGvAKPPYNRATNSQKCIRAG----DLENVGRTG 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697874 86 RHHTFFEMLGNFSFGDYFKHDAIQYAWELLTgeNWFNLPKERLWVTVYETDDEAYEIWEKEVGIPRERIIRIGDNkgapy 165
Cdd:pfam01411 77 RHHTFFEMLGNFSFGDYFKEEAIEYAWELLT--KELGLPPERLYVTVFEWDDEAGPIWEKIVGGPEERILRFGDK----- 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697874 166 asDNFWQMGDTGPCGPCTEIFYDHGDHIWGGPPGSPEE-DGDRYIEIWNIVFMQFNRQADGTMEPLPKPSVDTGMGLERI 244
Cdd:pfam01411 150 --DNFWEMGDTGPCGPCSEIDYDRGEEIGGWDSGGTPTaDDDRFLEIWNLVFMQFNRENDGTLKPLPKKSIDTGMGLERL 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697874 245 AAVLQHVNSNYEIDLFSTLIKAVAEVTGAT----DLNNKSLRVIADHIRSCAFLIADGVIPSNENRGYVLRRIIRRAIRH 320
Cdd:pfam01411 228 VAVLQDVRSNYDTDVFIPVIELIEEISGARyytvDETDEAYRVIADHTRALTFALADGVVPSNEGRGYVLRRILRRAVRH 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697874 321 GNMLGAKDTFFYKLVGPLIGVMGAAGDELKRQQAQVEQVLKTEEEQFARTLERGLALLDEELAKLK--GDTLDGETAFRL 398
Cdd:pfam01411 308 AKKLGLKEPFLYDLVPTVVEVLGDAYPELKEDEDFIQEILELEEERFAKTLERGLRLLERLIAKLKkgKKTLPGEDAFKL 387
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697874 399 YDTYGFPVDLTADVCRERNIKVDEVGFEAAMEEQRRRARESSGFG---ADYNAMIRVDSASEFKGYDALELTGKVTALFV 475
Cdd:pfam01411 388 YDTYGFPVDLTKEIAEERGLKVDMPGFEYAMVEQRERSKQAVKEKgekLDVSALKELPATTEFLGYDDLESEAKILALPK 467
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697874 476 DGKAVDSISAGQDAVVILDKTPFYAESGGQVGDKGELKGNGFSFSVSDTQKFGQAIGHQGKLVSGSLKVGEGVQANVDEA 555
Cdd:pfam01411 468 DGEFVAEVLAGQEGGVILDRTPFYAESGGQIGDTGYIIGDGGEFRVTDVQKYGGVVVHKGKLESGKLKVGDKVIAVIDED 547
|
.
gi 504697874 556 R 556
Cdd:pfam01411 548 R 548
|
|
| AlaRS_core |
cd00673 |
Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is ... |
5-251 |
2.27e-140 |
|
Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of the enzyme bound aminoacyl-adenylate. Class II assignment is based upon its predicted structure and the presence of three characteristic sequence motifs.
Pssm-ID: 238360 [Multi-domain] Cd Length: 232 Bit Score: 415.61 E-value: 2.27e-140
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697874 5 TAEIRQAFLDFFHSKGHQVVASSSLVPNNDPTLLFTNAGMNQFKDVFLGLDKRNYSRATTSQRCVRAGGKHNdlenVGYT 84
Cdd:cd00673 1 ASEIRETFLSFFEKKGHTRVPSSPVVPRDDPTLLFTNAGMNQFKPIFLGEVPPPANRLVNSQKCIRAGDIDN----VGKT 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697874 85 ARHHTFFEMLGNFSFGDYFKHDAIQYAWELLTGEnwFNLPKERLWVTVYETDDEAYEIWEKEVGIPRERIIRIGdnkgap 164
Cdd:cd00673 77 GRHHTFFEMLGNFSFGDYFKEEAIAFAWELLTEV--LGLPKDRLYVSVFEGDDEEEAIWWWKIGLPGIRIERIG------ 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697874 165 yASDNFWQMGDTGPCGPCTEIFYDHGDHIWGGPpgSPEEDGDRYIEIWNIVFMQFNRQADGTMEPLPKPSVDTGMGLERI 244
Cdd:cd00673 149 -FKDNFWEMGGNGPCGPCSEIFYDRGEERDAAS--LPNEDDDRYLEIWNLVFMQYNRDADGTYRPLPKKIVDTGMGLERL 225
|
....*..
gi 504697874 245 AAVLQHV 251
Cdd:cd00673 226 VWVLQGV 232
|
|
| tRNA_SAD |
smart00863 |
Threonyl and Alanyl tRNA synthetase second additional domain; The catalytically active form of ... |
653-695 |
3.12e-19 |
|
Threonyl and Alanyl tRNA synthetase second additional domain; The catalytically active form of threonyl/alanyl tRNA synthetase is a dimer. Within the tRNA synthetase class II dimer, the bound tRNA interacts with both monomers making specific interactions with the catalytic domain, the C-terminal domain, and this SAD domain (the second additional domain). The second additional domain is comprised of a pair of perpendicularly orientated antiparallel beta sheets, of four and three strands, respectively, that surround a central alpha helix that forms the core of the domain.
Pssm-ID: 197931 [Multi-domain] Cd Length: 43 Bit Score: 81.66 E-value: 3.12e-19
10 20 30 40
....*....|....*....|....*....|....*....|...
gi 504697874 653 VRVLSMGDFSTELCGGTHASRTGDIGLFRIVSESGTAAGVRRI 695
Cdd:smart00863 1 VRVVSIGDFSVELCGGTHVPNTGEIGAFKILSVSGAYWGLQRI 43
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| AlaS |
COG0013 |
Alanyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Alanyl-tRNA ... |
3-875 |
0e+00 |
|
Alanyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Alanyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439784 [Multi-domain] Cd Length: 880 Bit Score: 1621.28 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697874 3 KSTAEIRQAFLDFFHSKGHQVVASSSLVPNNDPTLLFTNAGMNQFKDVFLGLDKRNYSRATTSQRCVRAGGKHNDLENVG 82
Cdd:COG0013 2 MTSAEIRQKFLDFFESKGHTIVPSSSLVPKNDPTLLFTNAGMVQFKPYFLGQEKPPYPRATTSQKCVRTGGKHNDLENVG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697874 83 YTARHHTFFEMLGNFSFGDYFKHDAIQYAWELLTgeNWFNLPKERLWVTVYETDDEAYEIWEKEVGIPRERIIRIGdnkg 162
Cdd:COG0013 82 YTARHHTFFEMLGNFSFGDYFKEEAIAWAWELLT--EVLGLPKERLWVTVYEDDDEAYDIWKKEIGVPEERIIRLG---- 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697874 163 apyASDNFWQMGDTGPCGPCTEIFYDHGDHIWGGPPGSPEEDGDRYIEIWNIVFMQFNRQADGTMEPLPKPSVDTGMGLE 242
Cdd:COG0013 156 ---KKDNFWEMGDTGPCGPCSEIFYDRGPEYGGGPPGSPGEDGDRYIEIWNLVFMQFNRDEDGTLTPLPKKNIDTGMGLE 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697874 243 RIAAVLQHVNSNYEIDLFSTLIKAVAEVTGAT----DLNNKSLRVIADHIRSCAFLIADGVIPSNENRGYVLrriirrai 318
Cdd:COG0013 233 RIAAVLQGVHSNYETDLFRPLIEAAAELTGVKygadEEDDVSLRVIADHIRAVAFLIADGVLPSNEGRGYVLrrilrrav 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697874 319 rHGNMLGAKDTFFYKLVGPLIGVMGAAGDELKRQQAQVEQVLKTEEEQFARTLERGLALLDEELAKLK---GDTLDGETA 395
Cdd:COG0013 313 rHGRLLGIKEPFLYKLVPVVVEEMGDAYPELKEKQELIEKVLKAEEERFLRTLERGLKLLDEAIAKLKaagGKVLSGEDA 392
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697874 396 FRLYDTYGFPVDLTADVCRERNIKVDEVGFEAAMEEQRRRARESSGFGADYNA------MIRVDSASEFKGYDALELTGK 469
Cdd:COG0013 393 FKLYDTYGFPLDLTEEIARERGLTVDEEGFEAAMEEQRERARAAAKFSGDAAVdgvwreLLEEGGPTEFVGYDTLEAEAK 472
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697874 470 VTALFVDGKAVDSISAGQDAVVILDKTPFYAESGGQVGDKGELKGNGFSFSVSDTQK-FGQAIGHQGKLVSGSLKVGEGV 548
Cdd:COG0013 473 VLALVKDGELVDSAKAGEEVEVVLDRTPFYAESGGQVGDTGTIEGDGGVFEVTDTQKpPGGLIVHIGKVEEGELKVGDTV 552
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697874 549 QANVDEARRARIRLNHSATHLMHAALRDVLGTHVAQKGSLVNDKVLRFDFSHFEAMKPSEIRAVEDLVNAQIRRNLPIET 628
Cdd:COG0013 553 TAQVDAERRRAIARNHSATHLLHAALREVLGEHVTQAGSLVAPDRLRFDFSHFEALTPEELAEIEDLVNEKIRENLPVET 632
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697874 629 HIMDLEDAKKKGAMALFGEKYDERVRVLSMGDFSTELCGGTHASRTGDIGLFRIVSESGTAAGVRRIEAVTGEGAIASLH 708
Cdd:COG0013 633 REMPLDEAKALGAMALFGEKYGDEVRVVSIGDFSRELCGGTHVSRTGDIGLFKIVSESSVAAGVRRIEAVTGEAALEYLR 712
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697874 709 AQSDQLHDIAQLLKGDSQNLGEKVRVALERTRQLEKELQQLKEQAAAQESANLSSKAVDIKGVKLLVSDLAGVEPKMLRT 788
Cdd:COG0013 713 EQEALLKELAELLKAPPEELPERVEALLEELKELEKELEQLKAKLASAAADDLLAQAEEIGGVKVLAARVEGVDAKDLRD 792
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697874 789 MVDDLKNQLGSTVIVLATVAEGKVSLIAGVSKDVTDR-VKAGELIGMVAQQVGGKGGGRPDMAQAGGTDAAALPQALASV 867
Cdd:COG0013 793 LADDLKDKLGSGVVVLASVADGKVSLVAGVTKDLVKKgLKAGDLVKEVAKIVGGGGGGRPDMAQAGGKDPSKLDEALAAV 872
|
....*...
gi 504697874 868 ESWVSAKL 875
Cdd:COG0013 873 KEWLAEKL 880
|
|
| alaS |
TIGR00344 |
alanine--tRNA ligase; The model describes alanine--tRNA ligase. This enzyme catalyzes the ... |
7-854 |
0e+00 |
|
alanine--tRNA ligase; The model describes alanine--tRNA ligase. This enzyme catalyzes the reaction (tRNAala + L-alanine + ATP = L-alanyl-tRNAala + pyrophosphate + AMP). [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273026 [Multi-domain] Cd Length: 845 Bit Score: 1234.17 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697874 7 EIRQAFLDFFHSKGHQVVASSSLVPNNDPTLLFTNAGMNQFKDVFLGLDKRNYSRATTSQRCVRAggkhNDLENVGYTAR 86
Cdd:TIGR00344 1 EIRQTFLDFFKEKGHQVIPSAPLVPRNDPTLLLTNAGMAQFKPIFTGIVKPPSNRLTNAQPCIRL----NDLENVGRTAR 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697874 87 HHTFFEMLGNFSFGDYFKHDAIQYAWELLTgeNWFNLPKERLWVTVYETDDEAYEIWEKevgiprerIIRIGDNKGAPYA 166
Cdd:TIGR00344 77 HHTLFEMLGNFSFGDYFKEEAIAFAWELLT--EVLGLDKERLYVTVYEDDEEAYKIWEK--------IGIPADRIIKCDA 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697874 167 SDNFWQMGDtGPCGPCTEIFYDHgdhiWGGPPGSPEEDGDRYIEIWNIVFMQFNRQADGTMEPLPKPSVDTGMGLERIAA 246
Cdd:TIGR00344 147 KDNFWDMGD-GPCGPCTEIYYDF----VGGKPGEPLEENDRYLEVWNLVFMQFNRDPDGNYTPLPKKNIDTGMGLERFVA 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697874 247 VLQHVNSNYEIDLFSTLIKAVAEVTGATDLNNK-------------SLRVIADHIRSCAFLIADGVIPSNENRGYVLRRI 313
Cdd:TIGR00344 222 VLQGVPTNYDTDIFLPLIEKIEEITGVKYDSNNagimdekrvedlrSLRVIADHTRAIAFMLADGVVPSNEGRGYVLRRL 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697874 314 IRRAIRHGNMLGAKDTFFYKLVGPLIGVMGAAGDELKRQQAQVEQVLKTEEEQFARTLERGLALLDEELAKLKGDTLDGE 393
Cdd:TIGR00344 302 IRRALRHGKKLGLKEAFLYKLVPTLIEVLGDYYPELKEKQEFVEQILELEEERFAKTLERGLRLFEKLLKKTGKKELDGE 381
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697874 394 TAFRLYDTYGFPVDLTADVCRERNIKVDEVGFEAAMEEQRRRARESSGFGADYNAMIRVDSASEFKGYDALELTGKVTAL 473
Cdd:TIGR00344 382 DAFKLYDTYGFPVELTKEIAEERGLTVDMPGFEALMAEQRERSKQNSQFQEQEIALVNVYPATEFLGYDDLEFEAKVIGL 461
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697874 474 FVDGKAVDSISAGQDAVVILDKTPFYAESGGQVGDKGELKGNGFSFSVSDTQKFGQAIGHQGKLVSGSLKVGEGVQANVD 553
Cdd:TIGR00344 462 FDDGYLVEQALAGQSVYVILDQTPFYAESGGQIGDTGYLIANDGKFRVVDVQKPNGVVFHFGEVEGGSLKVGDKVIAVID 541
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697874 554 EARRARIRLNHSATHLMHAALRDVLGTHVAQKGSLVNDKVLRFDFSHFEAMKPSEIRAVEDLVNAQIRRNLPIETHIMDL 633
Cdd:TIGR00344 542 EKRRFRIMRNHSATHLLHAALQKVLGNHVWQAGSLVSFKKLRFDFSHFRALTREELEEIEDLANEQILANIPIKVIFMDL 621
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697874 634 EDAKKKGAMALFGEKY--DERVRVLSMGDFSTELCGGTHASRTGDIGLFRIVSESGTAAGVRRIEAVTGEGAIASLHAQS 711
Cdd:TIGR00344 622 DEAKRKGAFALFGEKYvpGEKVRVVSVGDFSVELCGGTHVRNTGEIGLFKIVKESGIAAGVRRIEAVTGEAAIEYLNEQE 701
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697874 712 DQLHDIAQLLKGDSQNLGEKVRVALERTRQLEKELQQLKEQAAAQESANLSSKAVDIKGVKLLVSDLAGVEPKMLRTMVD 791
Cdd:TIGR00344 702 DKLKELADILKVTPNELPKKVERFFEEWKALQKELESLKLKIADQKIDELKDKAETINGVKVLVEVVDAKDMKSLKTMAD 781
|
810 820 830 840 850 860
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 504697874 792 DLKNQLGSTVIVLATVAEGKVSLIAGVSKDV-TDRVKAGELIGMVAQQVGGKGGGRPDMAQAGG 854
Cdd:TIGR00344 782 RLKSKLGSAIYVLASFAEGKVKLVCGVSNDVlTKKIKAGELINQIAQVLGGKGGGRPDFAQGGG 845
|
|
| PLN02900 |
PLN02900 |
alanyl-tRNA synthetase |
4-873 |
0e+00 |
|
alanyl-tRNA synthetase
Pssm-ID: 215487 [Multi-domain] Cd Length: 936 Bit Score: 991.82 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697874 4 STAEIRQAFLDFFHSKGHQVVASSSLVPNNDPTLLFTNAGMNQFKDVFLG-----LDKRNYSRATTSQRCVRAGGKHNDL 78
Cdd:PLN02900 12 PGDRIRRTFLSFFESKGHTFLPSSPLVPVDDPTLLFTNAGMNQFKPIFLGtadpnTPLRKLPRATNTQKCIRAGGKHNDL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697874 79 ENVGYTARHHTFFEMLGNFSFGDYFKHDAIQYAWELLTGEnwFNLPKERLWVTVYETDD------EAYEIWEKEVgiPRE 152
Cdd:PLN02900 92 DDVGKDTYHHTFFEMLGNWSFGDYFKKEAIGWAWELLTKV--YGLPADRLYATYFGGDEkqapddEARAIWLDYL--PEE 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697874 153 RIIRIGdnkgapyASDNFWQMGDTGPCGPCTEIFYD-HGDHiwgGPPGSPEEDGDRYIEIWNIVFMQFNRQADGTMEPLP 231
Cdd:PLN02900 168 RVLPFG-------CKDNFWEMGDTGPCGPCSEIHYDrIGER---DAADLVNNDDPRFIEIWNLVFIQFNREADGSLKPLP 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697874 232 KPSVDTGMGLERIAAVLQHVNSNYEIDLFSTLIKAVAEVTGATDLNNKS-----------LRVIADHIRSCAFLIADGVI 300
Cdd:PLN02900 238 AKHVDTGMGLERLASILQNKPSNYDTDLFMPIFDAIQEATGARPYAGKVgaedddrvdmaYRVVADHIRTLSFAIADGVV 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697874 301 PSNENRGYVLRRIIRRAIRHGN-MLGAKDTFFYKLVGPLIGVMGAAGDELKRQQAQVEQVLKTEEEQFARTLERGLALLD 379
Cdd:PLN02900 318 PSNEGRGYVLRRLLRRAVRYGRlLLGAEEGFFPALVEVVVELSGDVFPEVKKNEKRITEIIAEEELSFGKTLEKGIEKFK 397
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697874 380 EELAKLK---GDTLDGETAFRLYDTYGFPVDLTADVCRERNIKVDEVGFEAAMEEQRRRARESsGFGADYNAMIRVDSAS 456
Cdd:PLN02900 398 KALAAAKangGPVLSGKDAFLLYDTYGFPVDLTELMAEERGVTVDMEGFEAAMEEARERSRAA-HLKAGGGAIELAAEAT 476
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697874 457 ------------EFKGYDALE-LTGKVTALFVDGKAVDSISAGQDAVVILDKTPFYAESGGQVGDKGELKG-NGFSFSVS 522
Cdd:PLN02900 477 swlqkqgvaatdDFLKYDWLSdHEAVVKAILTGGGFVESVSEGDEVGIVLDKTSFYAESGGQIGDTGVLEGsGGAVVEVS 556
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697874 523 DTQKFGQAIGHQGKLVSGSLKVGEGVQANVDEARRARIRLNHSATHLMHAALRDVLGTHVAQKGSLVNDKVLRFDFSHFE 602
Cdd:PLN02900 557 DVQKAGGFVLHIGTVTEGSVSVGDAVTCKVDYDRRRRIAPNHTATHLLNSALKEVLGDHVDQKGSLVAFEKLRFDFSHGK 636
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697874 603 AMKPSEIRAVEDLVNAQIRRNLPIETHIMDLEDAKK-KGAMALFGEKYDERVRVLSMGD-FSTELCGGTHASRTGDIGLF 680
Cdd:PLN02900 637 PMTPEELREVESLVNEWIGDALPVEAKEMPLADAKRiNGLRAVFGEKYPDPVRVVSVGGvYSMELCGGTHVSNTAEAEAF 716
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697874 681 RIVSESGTAAGVRRIEAVTGEGAIASLHAQSDQLHDIAQLLKGDSQNLGEKV----------------------RVA--L 736
Cdd:PLN02900 717 KLLSEEGIAKGIRRITAVTGGAAVEAINAADSLERELDSALKVEGSDLEKKVaslksrvdaavipaakkeeiraRVSalQ 796
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697874 737 ERTRQLEKELQQLKEQAAAQESANLSSKAVDIkGVKLLVSDLA-GVEPKMLRTMVDDLKNQLGSTVIVLATVAE--GKVS 813
Cdd:PLN02900 797 KELRAAQKEAAALRAKLAVAKATELASKALSA-GKSVLVARLDvGVDAAALKEAAEKVIAKLGDPAAVVLSSDEekGKVS 875
|
890 900 910 920 930 940
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 504697874 814 LIAGVSKDVTD-RVKAGELIGMVAQQVGGKGGGRPDMAQAGGTDAAALPQALASVESWVSA 873
Cdd:PLN02900 876 LVAAVPPGVVKkGLKAGKWLGAIAKLCGGGGGGKPGFAQGQGRDAEKLDAALEKARAFAVA 936
|
|
| tRNA-synt_2c |
pfam01411 |
tRNA synthetases class II (A); Other tRNA synthetase sub-families are too dissimilar to be ... |
7-556 |
0e+00 |
|
tRNA synthetases class II (A); Other tRNA synthetase sub-families are too dissimilar to be included. This family includes only alanyl-tRNA synthetases.
Pssm-ID: 279719 [Multi-domain] Cd Length: 548 Bit Score: 841.94 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697874 7 EIRQAFLDFFHSKGHQVVASSSLVPNNDPTLLFTNAGMNQFKDVFLGL-DKRNYSRATTSQRCVRAGgkhnDLENVGYTA 85
Cdd:pfam01411 1 EIRQTFLDFFEKKGHTRVPSSPVVPRNDPTLLFTNAGMNQFKPIFLGGvAKPPYNRATNSQKCIRAG----DLENVGRTG 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697874 86 RHHTFFEMLGNFSFGDYFKHDAIQYAWELLTgeNWFNLPKERLWVTVYETDDEAYEIWEKEVGIPRERIIRIGDNkgapy 165
Cdd:pfam01411 77 RHHTFFEMLGNFSFGDYFKEEAIEYAWELLT--KELGLPPERLYVTVFEWDDEAGPIWEKIVGGPEERILRFGDK----- 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697874 166 asDNFWQMGDTGPCGPCTEIFYDHGDHIWGGPPGSPEE-DGDRYIEIWNIVFMQFNRQADGTMEPLPKPSVDTGMGLERI 244
Cdd:pfam01411 150 --DNFWEMGDTGPCGPCSEIDYDRGEEIGGWDSGGTPTaDDDRFLEIWNLVFMQFNRENDGTLKPLPKKSIDTGMGLERL 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697874 245 AAVLQHVNSNYEIDLFSTLIKAVAEVTGAT----DLNNKSLRVIADHIRSCAFLIADGVIPSNENRGYVLRRIIRRAIRH 320
Cdd:pfam01411 228 VAVLQDVRSNYDTDVFIPVIELIEEISGARyytvDETDEAYRVIADHTRALTFALADGVVPSNEGRGYVLRRILRRAVRH 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697874 321 GNMLGAKDTFFYKLVGPLIGVMGAAGDELKRQQAQVEQVLKTEEEQFARTLERGLALLDEELAKLK--GDTLDGETAFRL 398
Cdd:pfam01411 308 AKKLGLKEPFLYDLVPTVVEVLGDAYPELKEDEDFIQEILELEEERFAKTLERGLRLLERLIAKLKkgKKTLPGEDAFKL 387
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697874 399 YDTYGFPVDLTADVCRERNIKVDEVGFEAAMEEQRRRARESSGFG---ADYNAMIRVDSASEFKGYDALELTGKVTALFV 475
Cdd:pfam01411 388 YDTYGFPVDLTKEIAEERGLKVDMPGFEYAMVEQRERSKQAVKEKgekLDVSALKELPATTEFLGYDDLESEAKILALPK 467
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697874 476 DGKAVDSISAGQDAVVILDKTPFYAESGGQVGDKGELKGNGFSFSVSDTQKFGQAIGHQGKLVSGSLKVGEGVQANVDEA 555
Cdd:pfam01411 468 DGEFVAEVLAGQEGGVILDRTPFYAESGGQIGDTGYIIGDGGEFRVTDVQKYGGVVVHKGKLESGKLKVGDKVIAVIDED 547
|
.
gi 504697874 556 R 556
Cdd:pfam01411 548 R 548
|
|
| PRK01584 |
PRK01584 |
alanyl-tRNA synthetase; Provisional |
7-701 |
3.78e-174 |
|
alanyl-tRNA synthetase; Provisional
Pssm-ID: 234962 [Multi-domain] Cd Length: 594 Bit Score: 516.63 E-value: 3.78e-174
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697874 7 EIRQAFLDFFHSKGHQVVASSSLVPNNDPTLLFTNAGMNQFKDVFLGLDKRNYSRATTSQRCVRAGgkhnDLENVGyTAR 86
Cdd:PRK01584 5 ELRKKYIDFFKSKGHVEIAGKSLIPENDPTVLFTTAGMHPLVPYLLGEPHPSGTRLVDVQKCLRTG----DIDEVG-DLS 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697874 87 HHTFFEMLGNFSFGDYFKHDAIQYAWELLTGENWFNLPKERLWVTVYETDD------EAYEIWEKeVGIPRERIIRIGdn 160
Cdd:PRK01584 80 HLTFFEMLGNWSLGAYFKEESIKYSFEFLTSPDYLNIPKDKLYVTVFEGDEeiprdeETASVWES-LGIPKDRIFYLS-- 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697874 161 kgapyASDNFW-QMGDTGPCGPCTEIFYDHGDhiwggPPGS----PEEDGDRYIEIWNIVFMQFNRQADGTMEPLPKPSV 235
Cdd:PRK01584 157 -----REHNWWgPVGETGPCGPDTEIFVDTGK-----PKCSvncrPTCSCGKYFEIWNNVFMQYNKDEDGNYEELKRKCV 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697874 236 DTGMGLERIAAVLQHVNSNYEIDLFSTLIKAVAEVTGA----TDLNNKSLRVIADHIRSCAFLIAD--GVIPSNENRGYV 309
Cdd:PRK01584 227 DTGMGIERTIAFLQGKSSVYDTEAFTPIIKRIEKISGKiygqNEEDDRSIRIIADHIRAACFILGDpfVVLPSNVGQGYV 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697874 310 LRRIIRRAIRHGNMLGAKDTFFYKLVGPLIGVMGAAGDELKRQQAQVEQVLKTEEEQFARTLERGLALLDEELAKLKGD- 388
Cdd:PRK01584 307 LRRLIRRSIRHAKKLGIESHFLADLVDSVEEIYGSFYPELTEKKDFIKEELNKEEEKFFKTLRKGEQEFIKLIPNLGSSk 386
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697874 389 TLDGETAFRLYDTYGFPVDLTADVCRERNIKVDEVGFEAAMEEQRRRAREssgfGADynamirvdsaSEFKGydaleltg 468
Cdd:PRK01584 387 IIPGDIAFKLYDTYGFPYEITEELASEYGFTVDREGFDEHFKKHQKVSKK----GAD----------KVFKG-------- 444
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697874 469 kvtalfvdgkavdsisagqdavvildktpfyaesggqvgdkgelkgnGFSFSVSDTQKFgqaighqgklvsgslkvgegv 548
Cdd:PRK01584 445 -----------------------------------------------GLADHSYETTKL--------------------- 456
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697874 549 qanvdearrarirlnHSATHLMHAALRDVLGTHVAQKGSLVNDKVLRFDFSHFEAMKPSEIRAVEDLVNAQIRRNLPIET 628
Cdd:PRK01584 457 ---------------HTATHLLHKALRLVLGDHVRQKGSNITAERLRFDFSHPEKMTDDEIKKVEDIVNLQIKNDLSVKK 521
|
650 660 670 680 690 700 710
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 504697874 629 HIMDLEDAKKKGAMALFGEKYDERVRVLSMGDFSTELCGGTHASRTGDIGLFRIVSESGTAAGVRRIEAVTGE 701
Cdd:PRK01584 522 EVMSLEEAREKGAMALFGEKYEDIVKVYEIDGFSKEVCGGPHVENTGELGTFKIQKEQSSSSGVRRIRAILID 594
|
|
| AlaRS_core |
cd00673 |
Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is ... |
5-251 |
2.27e-140 |
|
Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of the enzyme bound aminoacyl-adenylate. Class II assignment is based upon its predicted structure and the presence of three characteristic sequence motifs.
Pssm-ID: 238360 [Multi-domain] Cd Length: 232 Bit Score: 415.61 E-value: 2.27e-140
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697874 5 TAEIRQAFLDFFHSKGHQVVASSSLVPNNDPTLLFTNAGMNQFKDVFLGLDKRNYSRATTSQRCVRAGGKHNdlenVGYT 84
Cdd:cd00673 1 ASEIRETFLSFFEKKGHTRVPSSPVVPRDDPTLLFTNAGMNQFKPIFLGEVPPPANRLVNSQKCIRAGDIDN----VGKT 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697874 85 ARHHTFFEMLGNFSFGDYFKHDAIQYAWELLTGEnwFNLPKERLWVTVYETDDEAYEIWEKEVGIPRERIIRIGdnkgap 164
Cdd:cd00673 77 GRHHTFFEMLGNFSFGDYFKEEAIAFAWELLTEV--LGLPKDRLYVSVFEGDDEEEAIWWWKIGLPGIRIERIG------ 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697874 165 yASDNFWQMGDTGPCGPCTEIFYDHGDHIWGGPpgSPEEDGDRYIEIWNIVFMQFNRQADGTMEPLPKPSVDTGMGLERI 244
Cdd:cd00673 149 -FKDNFWEMGGNGPCGPCSEIFYDRGEERDAAS--LPNEDDDRYLEIWNLVFMQYNRDADGTYRPLPKKIVDTGMGLERL 225
|
....*..
gi 504697874 245 AAVLQHV 251
Cdd:cd00673 226 VWVLQGV 232
|
|
| AlaX |
COG2872 |
Ser-tRNA(Ala) deacylase AlaX (editing enzyme) [Translation, ribosomal structure and biogenesis] ... |
465-701 |
7.79e-37 |
|
Ser-tRNA(Ala) deacylase AlaX (editing enzyme) [Translation, ribosomal structure and biogenesis];
Pssm-ID: 442119 [Multi-domain] Cd Length: 238 Bit Score: 138.79 E-value: 7.79e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697874 465 ELTGKVTAlfvdgkavdsisAGQDAVVILDKTPFYAESGGQVGDKGELKGNGFSFSVSDTQKFGQAIGHQGKLVSGsLKV 544
Cdd:COG2872 14 EFEATVTA------------VTEEGGVVLDRTAFYPTGGGQPGDTGTLVWDGKEIRVVDVRKEDGEIVHVLEGAPL-PEV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697874 545 GEGVQANVDEARRARIRLNHSATHLMHAALRDVLGTHVAqKGSLVNDKVlRFDFsHFEAMKPSEIRAVEDLVNAQIRRNL 624
Cdd:COG2872 81 GDEVTGEIDWERRYRHMRLHTALHLLSAVVYREYGAPVT-GGQIGEDRA-RIDF-DLPEFDEEDLEEIEAEANELIAADL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697874 625 PIETHIMDLEDAKK-----KGAMALFGEKyDERVRVLSMGDFSTELCGGTHASRTGDIGLFRIVS-ESgTAAGVRRIEAV 698
Cdd:COG2872 158 PVRIYWITREELEAipglvRTMSVLPPPG-VGRVRIVEIGGVDLQPCGGTHVANTGEIGRIKITKiEK-KGKGNRRVYFT 235
|
...
gi 504697874 699 TGE 701
Cdd:COG2872 236 LGE 238
|
|
| DHHA1 |
pfam02272 |
DHHA1 domain; This domain is often found adjacent to the DHH domain pfam01368 and is called ... |
736-871 |
3.88e-29 |
|
DHHA1 domain; This domain is often found adjacent to the DHH domain pfam01368 and is called DHHA1 for DHH associated domain. This domain is diagnostic of DHH subfamily 1 members. This domains is also found in alanyl tRNA synthetase, suggesting that this domain may have an RNA binding function. The domain is about 60 residues long and contains a conserved GG motif.
Pssm-ID: 396724 [Multi-domain] Cd Length: 139 Bit Score: 113.31 E-value: 3.88e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697874 736 LERTRQLEKELQQLKEQAAAQESANLSSKAVDIKGVKLLVS-DLAGVEPKMLRTMVDDLKNQLGSTVIVLATVAEG-KVS 813
Cdd:pfam02272 5 NEELKELEKELEELKEALALLKAKELLEKAEEINGVKVLVAeVGEGWDAGALGIAADRLKKKLGDPVIVLVAKEDGdKVK 84
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 504697874 814 LIAGVSKDvtDRVKAGELIGMVAQQVGGKGGGRpDMAQAGGTDAAALPQALASVESWV 871
Cdd:pfam02272 85 VSARSSKD--KGVDAGELLKEVAAILGGGGGGH-DLAAGAGIDAEKLDEALELLEEAI 139
|
|
| tRNA_SAD |
smart00863 |
Threonyl and Alanyl tRNA synthetase second additional domain; The catalytically active form of ... |
653-695 |
3.12e-19 |
|
Threonyl and Alanyl tRNA synthetase second additional domain; The catalytically active form of threonyl/alanyl tRNA synthetase is a dimer. Within the tRNA synthetase class II dimer, the bound tRNA interacts with both monomers making specific interactions with the catalytic domain, the C-terminal domain, and this SAD domain (the second additional domain). The second additional domain is comprised of a pair of perpendicularly orientated antiparallel beta sheets, of four and three strands, respectively, that surround a central alpha helix that forms the core of the domain.
Pssm-ID: 197931 [Multi-domain] Cd Length: 43 Bit Score: 81.66 E-value: 3.12e-19
10 20 30 40
....*....|....*....|....*....|....*....|...
gi 504697874 653 VRVLSMGDFSTELCGGTHASRTGDIGLFRIVSESGTAAGVRRI 695
Cdd:smart00863 1 VRVVSIGDFSVELCGGTHVPNTGEIGAFKILSVSGAYWGLQRI 43
|
|
| tRNA_SAD |
pfam07973 |
Threonyl and Alanyl tRNA synthetase second additional domain; The catalytically active from of ... |
653-695 |
3.94e-17 |
|
Threonyl and Alanyl tRNA synthetase second additional domain; The catalytically active from of threonyl/alanyl tRNA synthetase is a dimer. Within the tRNA synthetase class II dimer, the bound tRNA interacts with both monomers making specific interactions with the catalytic domain, the C-terminal domain, and this domain (the second additional domain). The second additional domain is comprised of a pair of perpendicularly orientated antiparallel beta sheets, of four and three strands, respectively, that surround a central alpha helix that forms the core of the domain.
Pssm-ID: 429764 [Multi-domain] Cd Length: 43 Bit Score: 75.56 E-value: 3.94e-17
10 20 30 40
....*....|....*....|....*....|....*....|...
gi 504697874 653 VRVLSMGDFSTELCGGTHASRTGDIGLFRIVSESGTAAGVRRI 695
Cdd:pfam07973 1 VRVVSIGDFDVDLCGGTHVPNTGEIGAFKILKGESKNKGLRRI 43
|
|
| PLN02961 |
PLN02961 |
alanine-tRNA ligase |
490-683 |
1.98e-11 |
|
alanine-tRNA ligase
Pssm-ID: 178546 [Multi-domain] Cd Length: 223 Bit Score: 64.72 E-value: 1.98e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697874 490 VVILDKTPFYAESGGQVGDKG--ELKGNGFSFSVSDTQKFGQAIGHQGKLVSGS------LKVGEGVQANVDEARRariR 561
Cdd:PLN02961 4 ALVLDRTIFHPQGGGQPSDTGriVISGGDTKFSVQDVRRKDGVVYHYGVFEGSNpesaspFEAGDEVTVTVDESRR---K 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697874 562 LN---HSATHLMHAALRDVlgthvaQKGSLVNDKVLRF-DFSHFE---AMKPSEIRAVEDLVNAQ----IRRNLPIETHI 630
Cdd:PLN02961 81 LHsrlHSAGHLLDVCMARV------GLGPLEPGKGYHFpDGPFVEykgKIPQGELDSKQDELEAEanelIAEGGKVSAAV 154
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 504697874 631 MDLEDAKK--KGAMALFGEKyDERVRVLSMGDFSTELCGGTHASRTGDIGLFRIV 683
Cdd:PLN02961 155 LPYDEAAElcGGSLPDYIAK-DSTPRIVKIGDSPGCPCGGTHVADVSEITSVKVT 208
|
|
| class_II_aaRS-like_core |
cd00768 |
Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA ... |
7-244 |
3.79e-08 |
|
Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches the amino acid at the 2'-OH group, like class I aaRSs. These enzymes are usually homodimers. This domain is primarily responsible for ATP-dependent formation of the enzyme bound aminoacyl-adenylate. The substrate specificity of this reaction is further determined by additional domains. Intererestingly, this domain is also found is asparagine synthase A (AsnA), in the accessory subunit of mitochondrial polymerase gamma and in the bacterial ATP phosphoribosyltransferase regulatory subunit HisZ.
Pssm-ID: 238391 [Multi-domain] Cd Length: 211 Bit Score: 54.82 E-value: 3.79e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697874 7 EIRQAFLDFFHSKGHQVVASSSLVP--------NNDPTLLFTNA---GMNQFKDVFLGLDKRNYS--------RATTSQR 67
Cdd:cd00768 4 KIEQKLRRFMAELGFQEVETPIVERepllekagHEPKDLLPVGAeneEDLYLRPTLEPGLVRLFVshirklplRLAEIGP 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697874 68 CVRAGGKHNDLenvgytaRHHTFFEMLGNFSFGDYFkhdAIQYAWELLTgenwfnlpkerlwvtvyetddEAYEIWEKEV 147
Cdd:cd00768 84 AFRNEGGRRGL-------RRVREFTQLEGEVFGEDG---EEASEFEELI---------------------ELTEELLRAL 132
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697874 148 GIPRERIIRIGDNkgapyasDNFWqmgdTGPCGPCTEIFYDHGDHiwggppgspeedgdRYIEIWNIVFMQ--------- 218
Cdd:cd00768 133 GIKLDIVFVEKTP-------GEFS----PGGAGPGFEIEVDHPEG--------------RGLEIGSGGYRQdeqaraadl 187
|
250 260
....*....|....*....|....*.
gi 504697874 219 FNRQADGTMEPLPKPSVdtGMGLERI 244
Cdd:cd00768 188 YFLDEALEYRYPPTIGF--GLGLERL 211
|
|
| ThrS |
COG0441 |
Threonyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Threonyl-tRNA ... |
562-687 |
9.04e-05 |
|
Threonyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Threonyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440210 [Multi-domain] Cd Length: 639 Bit Score: 46.18 E-value: 9.04e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697874 562 LNHSATHLMHAALRDVL-GTHVA-----QKGslvndkvlrF--DFSHFEAMKPSEIRAVEDLVNAQIRRNLPIETHIMDL 633
Cdd:COG0441 71 LRHSAAHLLAQAVKRLYpDAKLTigpviENG---------FyyDFDLERPFTPEDLEKIEKEMKEIIKEDLPIEREEVSR 141
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 504697874 634 EDAKKKgaMALFGEKY----------DERVRVLSMGDFsTELCGGTHASRTGDIGLFRIVSESG 687
Cdd:COG0441 142 EEAIEL--FKEKGEPYkveliedipeDEEISLYRQGEF-VDLCRGPHVPSTGKIKAFKLLSVAG 202
|
|
| PLN02837 |
PLN02837 |
threonine-tRNA ligase |
553-677 |
5.71e-03 |
|
threonine-tRNA ligase
Pssm-ID: 215450 [Multi-domain] Cd Length: 614 Bit Score: 40.27 E-value: 5.71e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697874 553 DEARRARIRLNHSATHLMHAALRDVLGTHVAQKGSLVnDKVLRFDFShFEAMKPSEIRAVEDLVNAQIRRNLPIETHIMD 632
Cdd:PLN02837 37 NESSEKLLKIRHTCAHVMAMAVQKLFPDAKVTIGPWI-ENGFYYDFD-MEPLTDKDLKRIKKEMDRIISRNLPLVREEVS 114
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 504697874 633 LEDAKKKgAMALfGEKY---------DERVRVLSMGDFSTELCGGTHASRTGDI 677
Cdd:PLN02837 115 REEAQKR-IMAI-NEPYkleilegikEEPITIYHIGEEWWDLCAGPHVERTGKI 166
|
|
| PRK12444 |
PRK12444 |
threonyl-tRNA synthetase; Reviewed |
562-687 |
6.25e-03 |
|
threonyl-tRNA synthetase; Reviewed
Pssm-ID: 183530 [Multi-domain] Cd Length: 639 Bit Score: 40.12 E-value: 6.25e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504697874 562 LNHSATHLMHAALRDVLGTHVAQKGSLVNDKvLRFDFSHFEAMKPSEIRAVEDLVNAQIRRNLPIETHIMDLEDAKKkga 641
Cdd:PRK12444 75 ARHSAAHILAQAVKRLYGDVNLGVGPVIENG-FYYDMDLPSSVNVEDLRKIEKEMKKIINENIKIERVEVSREEAAK--- 150
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 504697874 642 maLFGEKYD-------------ERVRVLSMGDFsTELCGGTHASRTGDIGLFRIVSESG 687
Cdd:PRK12444 151 --LFQEMNDrlklelleaipsgESITLYKQGEF-VDLCRGPHLPSTGYLKAFQLTHVSG 206
|
|
| |
