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Conserved domains on  [gi|504799780|ref|WP_014986882|]
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FAD-dependent oxidoreductase [Nocardia brasiliensis]

Protein Classification

FAD-dependent oxidoreductase( domain architecture ID 12015107)

FAD-dependent oxidoreductase catalyzes the transfer of electrons from one molecule, the electron donor or reductant, to another molecule, the electron acceptor or oxidant; similar to D-amino acid oxidase

EC:  1.-.-.-
Gene Ontology:  GO:0071949|GO:0016491
SCOP:  3000055

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
DAO pfam01266
FAD dependent oxidoreductase; This family includes various FAD dependent oxidoreductases: ...
4-308 1.19e-30

FAD dependent oxidoreductase; This family includes various FAD dependent oxidoreductases: Glycerol-3-phosphate dehydrogenase EC:1.1.99.5, Sarcosine oxidase beta subunit EC:1.5.3.1, D-alanine oxidase EC:1.4.99.1, D-aspartate oxidase EC:1.4.3.1.


:

Pssm-ID: 426168 [Multi-domain]  Cd Length: 339  Bit Score: 117.88  E-value: 1.19e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504799780    4 DVLVLGAGVIGLTTAVCLAEAGHRVRVW-AELPPRQTTSAVASGLWGPGHT----PRDLAWSRVSFAELSRLAKEPASGV 78
Cdd:pfam01266   1 DVVVIGGGIVGLSTAYELARRGLSVTLLeRGDDPGSGASGRNAGLIHPGLRylepSELARLALEALDLWEELEEELGIDC 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504799780   79 HFER--GLQVSNlSAEPPHWMDDLG-------EAEFCRADELPE------GMLVGLWC-TAPLIDLPRYLDYLTDRLAAA 142
Cdd:pfam01266  81 GFRRcgVLVLAR-DEEEEALEKLLAalrrlgvPAELLDAEELRElepllpGLRGGLFYpDGGHVDPARLLRALARAAEAL 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504799780  143 GIEI-EQRRVRDLGEA--------TAAAPVVVNCTGVAAGKLVG---DAEVQPVRGQHVILR----NPGLTDFYVEFVQE 206
Cdd:pfam01266 160 GVRIiEGTEVTGIEEEggvwgvvtTGEADAVVNAAGAWADLLALpglRLPVRPVRGQVLVLEplpeALLILPVPITVDPG 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504799780  207 PEWTGIFPHGERLILGGARHPGRW-SLDPDPELAERILRRAIEVEPRLADaeVVGHEVGLRPGRTAARLDEEqLGGARVV 285
Cdd:pfam01266 240 RGVYLRPRADGRLLLGGTDEEDGFdDPTPDPEEIEELLEAARRLFPALAD--IERAWAGLRPLPDGLPIIGR-PGSPGLY 316
                         330       340
                  ....*....|....*....|...
gi 504799780  286 HNYGHDGMGVSLSWGSAREVVRL 308
Cdd:pfam01266 317 LATGHGGHGLTLAPGIGKLLAEL 339
 
Name Accession Description Interval E-value
DAO pfam01266
FAD dependent oxidoreductase; This family includes various FAD dependent oxidoreductases: ...
4-308 1.19e-30

FAD dependent oxidoreductase; This family includes various FAD dependent oxidoreductases: Glycerol-3-phosphate dehydrogenase EC:1.1.99.5, Sarcosine oxidase beta subunit EC:1.5.3.1, D-alanine oxidase EC:1.4.99.1, D-aspartate oxidase EC:1.4.3.1.


Pssm-ID: 426168 [Multi-domain]  Cd Length: 339  Bit Score: 117.88  E-value: 1.19e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504799780    4 DVLVLGAGVIGLTTAVCLAEAGHRVRVW-AELPPRQTTSAVASGLWGPGHT----PRDLAWSRVSFAELSRLAKEPASGV 78
Cdd:pfam01266   1 DVVVIGGGIVGLSTAYELARRGLSVTLLeRGDDPGSGASGRNAGLIHPGLRylepSELARLALEALDLWEELEEELGIDC 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504799780   79 HFER--GLQVSNlSAEPPHWMDDLG-------EAEFCRADELPE------GMLVGLWC-TAPLIDLPRYLDYLTDRLAAA 142
Cdd:pfam01266  81 GFRRcgVLVLAR-DEEEEALEKLLAalrrlgvPAELLDAEELRElepllpGLRGGLFYpDGGHVDPARLLRALARAAEAL 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504799780  143 GIEI-EQRRVRDLGEA--------TAAAPVVVNCTGVAAGKLVG---DAEVQPVRGQHVILR----NPGLTDFYVEFVQE 206
Cdd:pfam01266 160 GVRIiEGTEVTGIEEEggvwgvvtTGEADAVVNAAGAWADLLALpglRLPVRPVRGQVLVLEplpeALLILPVPITVDPG 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504799780  207 PEWTGIFPHGERLILGGARHPGRW-SLDPDPELAERILRRAIEVEPRLADaeVVGHEVGLRPGRTAARLDEEqLGGARVV 285
Cdd:pfam01266 240 RGVYLRPRADGRLLLGGTDEEDGFdDPTPDPEEIEELLEAARRLFPALAD--IERAWAGLRPLPDGLPIIGR-PGSPGLY 316
                         330       340
                  ....*....|....*....|...
gi 504799780  286 HNYGHDGMGVSLSWGSAREVVRL 308
Cdd:pfam01266 317 LATGHGGHGLTLAPGIGKLLAEL 339
DadA COG0665
Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];
4-310 1.82e-29

Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];


Pssm-ID: 440429 [Multi-domain]  Cd Length: 364  Bit Score: 115.00  E-value: 1.82e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504799780   4 DVLVLGAGVIGLTTAVCLAEAGHRVRVW-AELPPRQTTSAVA---SGLWGPGHTPRDLAWSRVSFAELSRLAKEPASGVH 79
Cdd:COG0665    4 DVVVIGGGIAGLSTAYHLARRGLDVTVLeRGRPGSGASGRNAgqlRPGLAALADRALVRLAREALDLWRELAAELGIDCD 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504799780  80 FER--GLQVSNLSAEPPH------WMDDLG-EAEFCRADELPE--------GMLVGLWC-TAPLIDLPRYLDYLTDRLAA 141
Cdd:COG0665   84 FRRtgVLYLARTEAELAAlraeaeALRALGlPVELLDAAELRErepglgspDYAGGLYDpDDGHVDPAKLVRALARAARA 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504799780 142 AGIEI-EQRRVRDL------------GEATAAAPVVVNCTGVAAGKLVGDA----EVQPVRGQHVILRNPGLTDFyVEFV 204
Cdd:COG0665  164 AGVRIrEGTPVTGLereggrvtgvrtERGTVRADAVVLAAGAWSARLLPMLglrlPLRPVRGYVLVTEPLPDLPL-RPVL 242
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504799780 205 QEPEWTGIFPHGERLILGGARHPGRWSLDPDPELAERILRRAIEVEPRLADAEVVGHEVGLRP---------GRTAARld 275
Cdd:COG0665  243 DDTGVYLRPTADGRLLVGGTAEPAGFDRAPTPERLEALLRRLRRLFPALADAEIVRAWAGLRPmtpdglpiiGRLPGA-- 320
                        330       340       350
                 ....*....|....*....|....*....|....*
gi 504799780 276 eeqlggARVVHNYGHDGMGVSLSWGSAREVVRLLA 310
Cdd:COG0665  321 ------PGLYVATGHGGHGVTLAPAAGRLLADLIL 349
PRK00711 PRK00711
D-amino acid dehydrogenase;
5-30 3.80e-05

D-amino acid dehydrogenase;


Pssm-ID: 234819 [Multi-domain]  Cd Length: 416  Bit Score: 44.79  E-value: 3.80e-05
                         10        20
                 ....*....|....*....|....*.
gi 504799780   5 VLVLGAGVIGLTTAVCLAEAGHRVRV 30
Cdd:PRK00711   3 VVVLGSGVIGVTSAWYLAQAGHEVTV 28
 
Name Accession Description Interval E-value
DAO pfam01266
FAD dependent oxidoreductase; This family includes various FAD dependent oxidoreductases: ...
4-308 1.19e-30

FAD dependent oxidoreductase; This family includes various FAD dependent oxidoreductases: Glycerol-3-phosphate dehydrogenase EC:1.1.99.5, Sarcosine oxidase beta subunit EC:1.5.3.1, D-alanine oxidase EC:1.4.99.1, D-aspartate oxidase EC:1.4.3.1.


Pssm-ID: 426168 [Multi-domain]  Cd Length: 339  Bit Score: 117.88  E-value: 1.19e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504799780    4 DVLVLGAGVIGLTTAVCLAEAGHRVRVW-AELPPRQTTSAVASGLWGPGHT----PRDLAWSRVSFAELSRLAKEPASGV 78
Cdd:pfam01266   1 DVVVIGGGIVGLSTAYELARRGLSVTLLeRGDDPGSGASGRNAGLIHPGLRylepSELARLALEALDLWEELEEELGIDC 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504799780   79 HFER--GLQVSNlSAEPPHWMDDLG-------EAEFCRADELPE------GMLVGLWC-TAPLIDLPRYLDYLTDRLAAA 142
Cdd:pfam01266  81 GFRRcgVLVLAR-DEEEEALEKLLAalrrlgvPAELLDAEELRElepllpGLRGGLFYpDGGHVDPARLLRALARAAEAL 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504799780  143 GIEI-EQRRVRDLGEA--------TAAAPVVVNCTGVAAGKLVG---DAEVQPVRGQHVILR----NPGLTDFYVEFVQE 206
Cdd:pfam01266 160 GVRIiEGTEVTGIEEEggvwgvvtTGEADAVVNAAGAWADLLALpglRLPVRPVRGQVLVLEplpeALLILPVPITVDPG 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504799780  207 PEWTGIFPHGERLILGGARHPGRW-SLDPDPELAERILRRAIEVEPRLADaeVVGHEVGLRPGRTAARLDEEqLGGARVV 285
Cdd:pfam01266 240 RGVYLRPRADGRLLLGGTDEEDGFdDPTPDPEEIEELLEAARRLFPALAD--IERAWAGLRPLPDGLPIIGR-PGSPGLY 316
                         330       340
                  ....*....|....*....|...
gi 504799780  286 HNYGHDGMGVSLSWGSAREVVRL 308
Cdd:pfam01266 317 LATGHGGHGLTLAPGIGKLLAEL 339
DadA COG0665
Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];
4-310 1.82e-29

Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];


Pssm-ID: 440429 [Multi-domain]  Cd Length: 364  Bit Score: 115.00  E-value: 1.82e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504799780   4 DVLVLGAGVIGLTTAVCLAEAGHRVRVW-AELPPRQTTSAVA---SGLWGPGHTPRDLAWSRVSFAELSRLAKEPASGVH 79
Cdd:COG0665    4 DVVVIGGGIAGLSTAYHLARRGLDVTVLeRGRPGSGASGRNAgqlRPGLAALADRALVRLAREALDLWRELAAELGIDCD 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504799780  80 FER--GLQVSNLSAEPPH------WMDDLG-EAEFCRADELPE--------GMLVGLWC-TAPLIDLPRYLDYLTDRLAA 141
Cdd:COG0665   84 FRRtgVLYLARTEAELAAlraeaeALRALGlPVELLDAAELRErepglgspDYAGGLYDpDDGHVDPAKLVRALARAARA 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504799780 142 AGIEI-EQRRVRDL------------GEATAAAPVVVNCTGVAAGKLVGDA----EVQPVRGQHVILRNPGLTDFyVEFV 204
Cdd:COG0665  164 AGVRIrEGTPVTGLereggrvtgvrtERGTVRADAVVLAAGAWSARLLPMLglrlPLRPVRGYVLVTEPLPDLPL-RPVL 242
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504799780 205 QEPEWTGIFPHGERLILGGARHPGRWSLDPDPELAERILRRAIEVEPRLADAEVVGHEVGLRP---------GRTAARld 275
Cdd:COG0665  243 DDTGVYLRPTADGRLLVGGTAEPAGFDRAPTPERLEALLRRLRRLFPALADAEIVRAWAGLRPmtpdglpiiGRLPGA-- 320
                        330       340       350
                 ....*....|....*....|....*....|....*
gi 504799780 276 eeqlggARVVHNYGHDGMGVSLSWGSAREVVRLLA 310
Cdd:COG0665  321 ------PGLYVATGHGGHGVTLAPAAGRLLADLIL 349
FAD_binding_2 pfam00890
FAD binding domain; This family includes members that bind FAD. This family includes the ...
4-66 7.47e-06

FAD binding domain; This family includes members that bind FAD. This family includes the flavoprotein subunits from succinate and fumarate dehydrogenase, aspartate oxidase and the alpha subunit of adenylylsulphate reductase.


Pssm-ID: 395718 [Multi-domain]  Cd Length: 398  Bit Score: 46.90  E-value: 7.47e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 504799780    4 DVLVLGAGVIGLTTAVCLAEAGHRVRVWAELPPRQTTSAVASG-LWGPGHTPRDLAWSRVSFAE 66
Cdd:pfam00890   1 DVLVIGGGLAGLAAALAAAEAGLKVAVVEKGQPFGGATAWSSGgIDALGNPPQGGIDSPELHPT 64
PRK00711 PRK00711
D-amino acid dehydrogenase;
5-30 3.80e-05

D-amino acid dehydrogenase;


Pssm-ID: 234819 [Multi-domain]  Cd Length: 416  Bit Score: 44.79  E-value: 3.80e-05
                         10        20
                 ....*....|....*....|....*.
gi 504799780   5 VLVLGAGVIGLTTAVCLAEAGHRVRV 30
Cdd:PRK00711   3 VVVLGSGVIGVTSAWYLAQAGHEVTV 28
PRK08626 PRK08626
fumarate reductase flavoprotein subunit; Provisional
4-46 1.73e-04

fumarate reductase flavoprotein subunit; Provisional


Pssm-ID: 181507 [Multi-domain]  Cd Length: 657  Bit Score: 43.04  E-value: 1.73e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 504799780   4 DVLVLGAGVIGLTTAVCLAEAGHRVRVWAELPPRQTTSAVASG 46
Cdd:PRK08626   7 DALVIGAGLAGLRVAIAAAQRGLDTIVLSLVPAKRSHSAAAQG 49
COG1233 COG1233
Phytoene dehydrogenase-related protein [Secondary metabolites biosynthesis, transport and ...
1-30 1.01e-03

Phytoene dehydrogenase-related protein [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440846 [Multi-domain]  Cd Length: 491  Bit Score: 40.60  E-value: 1.01e-03
                         10        20        30
                 ....*....|....*....|....*....|
gi 504799780   1 MADDVLVLGAGVIGLTTAVCLAEAGHRVRV 30
Cdd:COG1233    2 MMYDVVVIGAGIGGLAAAALLARAGYRVTV 31
PanE COG1893
Ketopantoate reductase [Coenzyme transport and metabolism]; Ketopantoate reductase is part of ...
5-32 1.23e-03

Ketopantoate reductase [Coenzyme transport and metabolism]; Ketopantoate reductase is part of the Pathway/BioSystem: Pantothenate/CoA biosynthesis


Pssm-ID: 441497 [Multi-domain]  Cd Length: 305  Bit Score: 39.84  E-value: 1.23e-03
                         10        20
                 ....*....|....*....|....*...
gi 504799780   5 VLVLGAGVIGLTTAVCLAEAGHRVRVWA 32
Cdd:COG1893    3 IAILGAGAIGGLLGARLARAGHDVTLVA 30
GlpB COG3075
Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism];
1-30 1.34e-03

Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism];


Pssm-ID: 442309  Cd Length: 415  Bit Score: 40.16  E-value: 1.34e-03
                         10        20        30
                 ....*....|....*....|....*....|
gi 504799780   1 MADDVLVLGAGVIGLTTAVCLAEAGHRVRV 30
Cdd:COG3075    1 MKFDVVVIGGGLAGLTAAIRAAEAGLRVAI 30
Ugd COG1004
UDP-glucose 6-dehydrogenase [Cell wall/membrane/envelope biogenesis];
7-28 1.37e-03

UDP-glucose 6-dehydrogenase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440628 [Multi-domain]  Cd Length: 436  Bit Score: 40.00  E-value: 1.37e-03
                         10        20
                 ....*....|....*....|..
gi 504799780   7 VLGAGVIGLTTAVCLAEAGHRV 28
Cdd:COG1004    5 VIGTGYVGLVTAACLAELGHEV 26
COG3349 COG3349
Uncharacterized protein, contains NAD-binding domain and a Fe-S cluster [General function ...
1-30 1.43e-03

Uncharacterized protein, contains NAD-binding domain and a Fe-S cluster [General function prediction only];


Pssm-ID: 442577 [Multi-domain]  Cd Length: 445  Bit Score: 39.84  E-value: 1.43e-03
                         10        20        30
                 ....*....|....*....|....*....|
gi 504799780   1 MADDVLVLGAGVIGLTTAVCLAEAGHRVRV 30
Cdd:COG3349    2 MPPRVVVVGGGLAGLAAAVELAEAGFRVTL 31
HdrA COG1148
Heterodisulfide reductase, subunit A (polyferredoxin) [Energy production and conversion];
1-28 2.76e-03

Heterodisulfide reductase, subunit A (polyferredoxin) [Energy production and conversion];


Pssm-ID: 440762 [Multi-domain]  Cd Length: 563  Bit Score: 39.07  E-value: 2.76e-03
                         10        20
                 ....*....|....*....|....*...
gi 504799780   1 MADDVLVLGAGVIGLTTAVCLAEAGHRV 28
Cdd:COG1148  139 VNKRALVIGGGIAGMTAALELAEQGYEV 166
PRK05329 PRK05329
glycerol-3-phosphate dehydrogenase subunit GlpB;
1-30 3.12e-03

glycerol-3-phosphate dehydrogenase subunit GlpB;


Pssm-ID: 235412  Cd Length: 422  Bit Score: 39.06  E-value: 3.12e-03
                         10        20        30
                 ....*....|....*....|....*....|
gi 504799780   1 MADDVLVLGAGVIGLTTAVCLAEAGHRVRV 30
Cdd:PRK05329   1 MKFDVLVIGGGLAGLTAALAAAEAGKRVAL 30
UDPG_MGDP_dh_N pfam03721
UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; The UDP-glucose/GDP-mannose ...
7-28 6.21e-03

UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; The UDP-glucose/GDP-mannose dehydrogenaseses are a small group of enzymes which possesses the ability to catalyze the NAD-dependent 2-fold oxidation of an alcohol to an acid without the release of an aldehyde intermediate.


Pssm-ID: 397677 [Multi-domain]  Cd Length: 186  Bit Score: 37.23  E-value: 6.21e-03
                          10        20
                  ....*....|....*....|..
gi 504799780    7 VLGAGVIGLTTAVCLAEAGHRV 28
Cdd:pfam03721   5 VIGLGYVGLPTAACLAEIGHDV 26
YobN COG1231
Monoamine oxidase [Amino acid transport and metabolism];
4-30 7.07e-03

Monoamine oxidase [Amino acid transport and metabolism];


Pssm-ID: 440844 [Multi-domain]  Cd Length: 440  Bit Score: 37.98  E-value: 7.07e-03
                         10        20
                 ....*....|....*....|....*..
gi 504799780   4 DVLVLGAGVIGLTTAVCLAEAGHRVRV 30
Cdd:COG1231    9 DVVIVGAGLAGLAAARELRKAGLDVTV 35
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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