|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
34-421 |
2.60e-81 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 254.80 E-value: 2.60e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 34 QILPILMFAYVTSYIDRVNVSFAKLQMSQHLGFSDAVFGFGAGIFFLGYVIFEVPSNMLLVRVGPRRWITRIVVSWGIVS 113
Cdd:cd17319 3 RIIPLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFT 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 114 GLTALVSTPMQFYVMRFLLGVAEAGFIPAIVLYMARSFPGRRRARILSMFYAALALAGLIGSPLTGFILQYFdgamqipG 193
Cdd:cd17319 83 ALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLF-------G 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 194 WKWIFILEALPAFLAALYVWKGLdddvtrserfshadrailarvlaedrataepvnhrglfsnWLVWAFCAIYFLDVFAI 273
Cdd:cd17319 156 WRWAFIIEGLLGLLLAVLWWFYL----------------------------------------RQVWGLALGYFGINYAL 195
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 274 YGYTFWAPTMIKQMGIGSDFVIGLLAALPNAVAVVVMVLFGRSADR--RGGRRLHVATLLLMGATGLGLSVVWHDqLWLG 351
Cdd:cd17319 196 YGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRllRGARRLVIIIGLLLAAVGLLLAYLTTS-PVVA 274
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 352 MFALCIANAGLISFPPLFWSMPTAALGTASVSMGIAVISSVGNLGGFFGPYAVGYLKQLSGNLAAPLFLM 421
Cdd:cd17319 275 VILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATGSYTAAFLFL 344
|
|
| 2A0114 |
TIGR00893 |
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ... |
42-415 |
7.70e-64 |
|
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273326 [Multi-domain] Cd Length: 399 Bit Score: 211.04 E-value: 7.70e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 42 AYVTSYIDRVNVSFAKLQMSQHLGFSDAVFGFGAGIFFLGYVIFEVPSNMLLVRVGPRRWITRIVVSWGIVSGLTALVST 121
Cdd:TIGR00893 2 VTVINYLDRANLSFAAPMLQEDLGLSAAQYGYVFSAFSWGYVVGQFPGGWLLDRFGARKTLAVFIVIWGVFTGLQAFAGA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 122 PMQFYVMRFLLGVAEAGFIPAIVLYMARSFPGRRRARILSMFYAALALAGLIGSPLTGFILQYFdgamqipGWKWIFILE 201
Cdd:TIGR00893 82 YVSLYILRVLLGAAEAPFFPGIILIVASWFPASERATAVSIFNSAQGLGGIIGGPLVGWILIHF-------SWQWAFIIE 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 202 ALPAFLAALYVWKGLDDDVTRSERFSHADRAILARVLAEDRATAEPVNH-----RGLFSNWLVWAFCAIYFLDVFAIYGY 276
Cdd:TIGR00893 155 GVLGIIWGVLWLKFIPDPPQKAKWLTEEEKYIVVGGLLAEQQGKGPSTPkkyqiKELLKDRRVWGLALGQFLVNIGLGFF 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 277 TFWAPTMIKQMGIGSDFVIGLLAALPNAVAVVVMVLFGRSADRRGGRRLHVATLLLMGAT-GLGLSVVWH--DQLWLGMF 353
Cdd:TIGR00893 235 LTWFPTYLVQERGLSILEAGFMASLPGIVGFIGMILGGRLSDLLLRRGKSLVFARKTAIIaGLVLSLLMFatNYVNIPYA 314
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 504814691 354 ALCIANAGLIS--FPPLFWSMPTAALGTASVSMGIAVISSVGNLGGFFGPYAVGYLKQLSGNLA 415
Cdd:TIGR00893 315 ALALVALGFFGlgAGAIGWALISDNAPGNIAGLTGGLINSLGNLGGIVGPIVIGAIAATTGSFA 378
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
25-420 |
4.57e-58 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 194.70 E-value: 4.57e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 25 DRIFRRLAVQILPILMFAYVTSYIDRVNVSFAKLQMSQHLGFSDAVFGFGAGIFFLGYVIFEVPSNMLLVRVGPRRWITR 104
Cdd:COG2271 1 ARAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 105 IVVSWGIVSGLTALVSTPMQFYVMRFLLGVAEAGFIPAIVLYMARSFPGRRRARILSMFYAALALAGLIGSPLTGFILQY 184
Cdd:COG2271 81 GLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 185 FdgamqipGWKWIFILEALPAFLAALyvwkgldddvtrserfshadrailarvlaedrataepvnhrglfsnWLVWAFCA 264
Cdd:COG2271 161 F-------GWRAAFLILGLPGLLLAL----------------------------------------------LRFWLLAL 187
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 265 IYFLDVFAIYGYTFWAPTMIKQMGIGSDFVIGLLAALPNAVAVVVMVLFGRSADRRGGRRLHVATLLLMGATGLGLSVVW 344
Cdd:COG2271 188 AYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALALLLLAL 267
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 504814691 345 HDQLWLGMFALCIANAGLISFPPLFWSMPTAALGTASVSMGIAVISSVGNLGGFFGPYAVGYLKQLSGNLAAPLFL 420
Cdd:COG2271 268 LPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLL 343
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
35-421 |
1.57e-45 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 162.36 E-value: 1.57e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 35 ILPILMFAYVTSYIDRVNVSFAKLQMSQHLGFSDAVFGFGAGIFFLGYVIFEVPSNMLLVRVGPRRWITRIVVSWGIVSG 114
Cdd:COG2223 6 VLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 115 LTALVSTPMQFYVMRFLLGVAEAGFIPAIVLYMARSFPGRRRARILSMFYAALALAGLIGSPLTGFILQYFdgamqipGW 194
Cdd:COG2223 86 LLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAF-------GW 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 195 KWIFILEALPAFLAALYVWKGLDDDVtrserfshadrailarVLAEDRATAEPVNHRGLFSNWLVWAFCAIYFLDVFAIY 274
Cdd:COG2223 159 RNAFLILGILLLVVAVLAWLFLRDPP----------------AGAAAAAKASLRDQLEALRDPRFWLLSLLYFGTFGSFI 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 275 GYTFWAPTMIKQMGIGSDFVIGLLAALPNAVAVVVMVLFGRSADRRGGRRLHVATLLLMGATGLGLSVVwHDQLWLGMFA 354
Cdd:COG2223 223 GFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALA-LGSLWLFLVL 301
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 504814691 355 LCIANAGLISFPPLFWSMPTAALGTASVSMGIAVISSVGNLGGFFGPYAVGYLKQLSGNLAAPLFLM 421
Cdd:COG2223 302 FLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAAFLVF 368
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
35-403 |
1.62e-45 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 162.80 E-value: 1.62e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 35 ILPILMFAYVTSYIDRVNVSFAKLQ-MSQHLGFSDAVFGFGAGIFFLGYVIFEVPSNMLLVRVGPRRWITRIVVSWGIVS 113
Cdd:cd17327 6 ILPLLCILYFLQYLDKSNISNAAVMgMKEDLKLVGNQYNWGNTVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGLLT 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 114 GLTALVSTPMQFYVMRFLLGVAEAGFIPAIVLYMARSFPGRRRARILSMFYAALALAGLIGSpLTGFILQYFDGAMQIPG 193
Cdd:cd17327 86 LLTAAVKNFGGLIALRFFLGLFESGVFPGFILYLGMWYKREEQAKRIAFFYAAAGLGSIFGG-LLAYGVFKILGVGGLAG 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 194 WKWIFILEALPAFLAALYVWKGLDDDVTRSERFSHADRAILARVLAEDRATAePVNHRGL------FSNWLVWAFCAIYF 267
Cdd:cd17327 165 WRWLFIIEGLITIIIGLVIFFWLPDNPSKAWFLTEEEKELAVERLRANQTGK-GDQKFKWkqikeaFKDPRTWLLFLFFF 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 268 LDVFAIYGYTFWAPTMIKQMGiGSDFVIGLLAALPNAVAVVVMVLFGRSADRRGGRRLHVATLLLMGATGlGLSVVWHDQ 347
Cdd:cd17327 244 CSQITNNGISNFLPLILKSLG-FYSLQTNLLSVPIGALGAVSLLIAALLSDRFKKRGLFAIFACVLALVG-SIILLAAPN 321
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 504814691 348 LWLGMFALCIANAGLISFPPLFWSMPTAALGTASV-SMGIAVISSVGNLGGFFGPYA 403
Cdd:cd17327 322 PPGAYFAAYILGGGSYAGFPILLSWISSNCAGYTKrATVLAIMLIFYNVGNIVAPQI 378
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
29-397 |
5.58e-31 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 122.00 E-value: 5.58e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 29 RRLAVQILPILMFAYVTSYIDRVNVSFAKLQMSQHLGFSDAVFGFGAGIFFLGYVIFEVPSNMLLVRVGPRRWITRIVVS 108
Cdd:COG2814 5 PRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 109 WGIVSGLTALVSTPMQFYVMRFLLGVAEAGFIPAIVLYMARSFPGRRRARILSMFYAALALAGLIGSPLTGFILQYFdga 188
Cdd:COG2814 85 FALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLF--- 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 189 mqipGWKWIFILEALPAFLAALYVWKGLDDDVTRserfshadrailarvlaedRATAEPVNHRGLFSNWLVWAFCAIYFL 268
Cdd:COG2814 162 ----GWRWVFLVNAVLALLALLLLLRLLPESRPA-------------------ARARLRGSLRELLRRPRLLLLLLLAFL 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 269 DVFAIYGYTFWAPTMIKQMGIGSDFVIGLLAALPNAVAVVVMVLFGRSADRRGGRRLHVATLLLMGATGLGLSVVwhDQL 348
Cdd:COG2814 219 LGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALA--GSL 296
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 504814691 349 WLGMFALCIANAGLISFPPLFWSMPTAALGTASVSMGIAVISSVGNLGG 397
Cdd:COG2814 297 WLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGG 345
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
39-401 |
2.91e-28 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 114.44 E-value: 2.91e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 39 LMFAYVTSYIDRVNVSFA-KLQMSQHLGFSDAVFGFGAGIFFLGYVIFEVPSNMLLVRVGPRRWITRIVVSWGIVSGLTA 117
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPAlPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 118 LVSTPMQFYVMRFLLGVAEAGFIPAIVLYMARSFPGRRRARILSMFYAALALAGLIGSPLTGFILQYFdgamqipGWKWI 197
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLF-------GWRAA 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 198 FILEALPAFLAALYVWKGLDDDVTRSERFSHADRAILARVLaedrataepvnhRGLFSNWLVWAFCAIYFLdVFAIYGYT 277
Cdd:pfam07690 154 FLILAILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAW------------KALLRDPVLWLLLALLLF-GFAFFGLL 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 278 FWAPTMIKQMGIgSDFVIGLLAALPNAVAVVVMVLFGRSADRRGGRRLHVATLLLMGATGLGLSVVWH-DQLWLGMFALC 356
Cdd:pfam07690 221 TYLPLYQEVLGL-SALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLtLSSLWLLLALL 299
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 504814691 357 IANAGLISFPPLFWSMPTAALGTASVSMGIAVISSVGNLGGFFGP 401
Cdd:pfam07690 300 LLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
39-421 |
6.79e-25 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 105.20 E-value: 6.79e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 39 LMFAYVTSYIDRVNVSFAKLQMSQHLGFSDAVFGFGAGIFFLGYVIFEVPSNMLLVRVGPRRWITRIVVSWGIVSGLTAL 118
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 119 VSTPMQFYVMRFLLGVAEAGFIPAIVLYMARSFPGRRRARILSMFYAALALAGLIGSPLTGFILQYFDGamqipGWKWIF 198
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGF-----GWRAVF 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 199 ILEALPAFLAALYVWKGLDDDVTRSERFSHADRAILARVLAedrataepvnhRGLFSNWLVWAFCAIYFLDVFAIYGYTF 278
Cdd:cd06174 156 LIAAALALLAAILLLLVVPDPPESARAKNEEASSKSVLKLL-----------KRVLKNPGLWLLLLAIFLVNLAYYSFST 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 279 WAPTMIKQMGIGSDFVIGLLAALPNAVAVVVMVLFGRSADRRGGRRLHVATLLLMGATGLGLsVVWHDQLWLGMFALCIA 358
Cdd:cd06174 225 LLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLAL-LLLAPSLLLLLLLLLLL 303
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 504814691 359 NAGLISFPPLFWSMPTAALGTASVSMGIAVISSVGNLGGFFGPYAVGYLKQLSGNLAAPLFLM 421
Cdd:cd06174 304 GFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVL 366
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
59-421 |
8.05e-24 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 102.64 E-value: 8.05e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 59 QMSQHLGFSDAVFGFGAGIFFLGYVIFEVPSNMLLVRVGPRRWITRIVVSWGIVSGLTALVSTPMQFYVMRFLLGVAEAG 138
Cdd:COG2807 43 EIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAV 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 139 FIPAIVLYMARSFPgRRRARILSMFYAALALAGLIGSPLTGFILQYFdgamqipGWKWIFILEALPAFLAALYVWkgldd 218
Cdd:COG2807 123 GNVLLPGLIKRWFP-DRVGLMTGLYTAAMGLGAALAAGLTVPLAAAL-------GWRGALAVWALLALLALLLWL----- 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 219 dvtrserfshadrAILARVLAEDRATAEPVNHRGLFSNWLVWAFCAIYFLDVFAIYGYTFWAPTMIKQMGIGSDFvIGLL 298
Cdd:COG2807 190 -------------PLLRRRPAAAAAAPAAASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRDAGLSAAT-AGLL 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 299 AALPNAVAVVVMVLFGRSADRRGGRRLHVATLLLMGATG-LGLSVVWHDQLWLGMFALCIANAGLISFPPLFWSMPTAAL 377
Cdd:COG2807 256 LSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLGLAGlLGLLLAPGSLPWLWAVLLGLGQGGLFPLALTLIGLRARTP 335
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 504814691 378 GTASVSMGIAVisSVGNLGGFFGPYAVGYLKQLSGNLAAPLFLM 421
Cdd:COG2807 336 AEAAALSGMAQ--SVGYLLAALGPLLVGALHDATGSWTAALLLL 377
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
62-412 |
1.17e-23 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 101.88 E-value: 1.17e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 62 QHLGFSDAVFGFGAGIFFLGYVIFEVPSNMLLVRVGPRRWITRIVVSWGIVSGLTALVSTPMQFYVMRFLLGVAEAGFIP 141
Cdd:cd17325 24 ESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLASAAVWP 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 142 AIVLYMARSFPGRRRARILSMFYAALALAGLIGSPLTGFILQYFdgamqipGWKWIFILEALPAFLAALYVWKGLDDDVT 221
Cdd:cd17325 104 AAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADAL-------GYRAPFLVCAALALLALVLALLLLPEPRP 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 222 RSERFSHADRAILARVlaedrataepvnhRGLFSNWLVWAFCAIYFLDVFAIYGYTFWAPTMIKQMGIGSDFVIGLLAAL 301
Cdd:cd17325 177 PPNKRAVSAARLRSGL-------------RLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGA 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 302 PNAVAVVVMVLFGRSADRRGGRRLHVATLLLMGATGLGLSVVwhDQLWLGMFALCIANAGL-ISFPPLFwSMPTAALGTA 380
Cdd:cd17325 244 QGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLA--TSFWLLLLLLALLGLGLgLVFPATL-ALLADIVPPE 320
|
330 340 350
....*....|....*....|....*....|..
gi 504814691 381 SVSMGIAVISSVGNLGGFFGPYAVGYLKQLSG 412
Cdd:cd17325 321 GRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFG 352
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
36-410 |
2.06e-22 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 98.46 E-value: 2.06e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 36 LPILMFAYVTSYIDRVNVSFAKLQMSQHLGFSDAVFGFGAGIFFLGYVIFEVPSNMLLVRvGPRRWITRI-VVSWGIVSG 114
Cdd:cd17328 1 VAVLFLINLLNYMDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDR-YNRKWILAVgILIWSAATL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 115 LTALVSTPMQFYVMRFLLGVAEAGFIPAIVLYMARSFPGRRRARILSMFYAALALAGLIGSPLTGFIlqyfdgAMQIPGW 194
Cdd:cd17328 80 LSSFAPNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLV------AQATGGW 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 195 KWIFILEALPAFLAALYVWKGLdDDVTRSERFSHADRAILARVLAEDRataepvnhRGLFSNWLVWAFCAIYFLDVFAIY 274
Cdd:cd17328 154 RWAFRVTGVLGVLLAILLLLFV-REPPRGAAEGGVMAKSTATSFLADL--------KALAKNPSFILSTLGFTAVSFVTG 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 275 GYTFWAPTMIK---QMGIGSDFVIGLLAALPNAVAVVVMVLFGRSADRRGGRR------LHVATLLLMGATGLGLSVVWH 345
Cdd:cd17328 225 ALAFWAPTFFLrafGVGDLSSADVGLIFGAITCIAGVLGVLLGGILADRLRRKtpradpLVCAVGLLAAAPFLFLALVLA 304
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 504814691 346 DQLWLGMFALCIANAGLISfpplFWSMPTAALGTASV-----SMGIAVISSVGN-LGGFFGPYAVGYLKQL 410
Cdd:cd17328 305 LSNLLLAWVLLFLGEFLLS----LNWAPVFAILLYVViptrrSTASAIQILLSHlLGDAGSPYLIGLISDL 371
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
59-419 |
9.36e-22 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 96.08 E-value: 9.36e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 59 QMSQHLGFSDAVFGFGAGIFFLGYVIFEVPSNMLLVRVGPRRWITRIVVSWGIVSGLTALVSTPMQFYVMRFLLGVAEAG 138
Cdd:cd17324 24 DIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGG 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 139 FIPAIVLYMARSFPGRRRARILSMFYAALALAGLIGSPLTGFILQYFdgamqipGWKWIFILEALPAFLAALYVWKGLDD 218
Cdd:cd17324 104 FWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLL-------GWRAAFLAIAVLALLAALLLWRLLPS 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 219 DVTRSERFSHADRAILArvlaedrataepvnhrgLFSNWLVWAFCAIYFLDVFAIYG-YTFWAPTMIKQMGIGSDFVIGL 297
Cdd:cd17324 177 LPPKKPGSLGLLSSLLL-----------------LLRNPRLRLAYLITFLLFGGFFAlYTYLAPFLTDVPGFSSSAIIGL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 298 LAALpNAVAVVVMVLFGRSADRRGGRRLHVATLLLMGAtgLGLSVVWHDQLWLGMFALCIANAGLISFPPLFWSMpTAAL 377
Cdd:cd17324 240 LLLF-GVAGVVGSPLAGRLADRGGRRALLIALLLLAAA--LLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTR-VLRL 315
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 504814691 378 GTASVSMGIAVISSVGNLGGFFGPYAVGYLKQLSGNLAAPLF 419
Cdd:cd17324 316 APEARGLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWV 357
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
38-421 |
1.51e-19 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 89.58 E-value: 1.51e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 38 ILMFAYVTSYIDRVNVSFAKLQMSQH--LGFSDAVFGFGAGIFFLGYVIFEVPSNMLLVRVGPRRWITRIVVSWGIVSGL 115
Cdd:cd17316 3 LAGLGWFFDAYDFFLIGFVAPVLAAEfsLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 116 TALVSTPMQFYVMRFLLGVAEAGFIPAIVLYMARSFPGRRRARILSMFYAALALAGLIGSpLTGFILQYFDGamQIPGWK 195
Cdd:cd17316 83 IGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAA-LVASLLIPLLS--GDWGWR 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 196 WIFILEALPAFLAALYvwkgldddvtrserfshadrailarvlaedrataepvnHRGLFSNWLVWAFCAIYFldvfaiYG 275
Cdd:cd17316 160 ILFLIGALPALLALLL--------------------------------------RRRTLLLILLWFFISFGY------YG 195
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 276 YTFWAPTMIKQMGIGSDFVIGLLAALPNAVAVVVMVLFGRSADRRGGRRLHVATLLLMGATGLGLSVVWHDQLWLGMFAL 355
Cdd:cd17316 196 LTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLLSGSPTLLLLLL 275
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 504814691 356 CIANAGLISFPPLFWSMPTAALGTASVSMGIAVISSVGNLGGFFGPYAVGYLKQLSGNLAAPLFLM 421
Cdd:cd17316 276 FILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALIL 341
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
41-412 |
8.03e-18 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 84.73 E-value: 8.03e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 41 FAYVTSYIDRVNVSFAKLQMSQHLGFSDAVFGFGAGIFFLGYVIFEVPSNMLLVRVGPRRWITRIVVSWGIVSGLTALVS 120
Cdd:TIGR00881 2 IGYAAYYLVRKNFALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFST 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 121 TPMQFYVMRFLLGVAEAGFIPAIVLYMARSFPGRRRARILSMFYAALALAGLIGSPLTGFILQYFDgamqipGWKWIFIL 200
Cdd:TIGR00881 82 SLWVMAALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLFGIAELY------SWHWVFIV 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 201 EALPAFLAALYVWKGLDDD-----VTRSERFSHADRAILARVlAEDRATAEPVNHRGLFSNWLVWAFCAIYFLDVFAIYG 275
Cdd:TIGR00881 156 PGIIAIIVSLICFLLLRDSpqscgLPPAEEMPNEEPDGDAEK-KEEELTKKQIFLQYVLLNKVLWYISLGYVFVYVVRTG 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 276 YTFWAPTMIKQMGIGSDFVIGLLAALPNAVAVVVMVLFGRSADRRGGRRLHVATLLLMGATGLGLSVVWH----DQLWLG 351
Cdd:TIGR00881 235 ILDWSPLYLTQEKGFSKEKASWAFTLYELGGLVGTLLAGWLSDKLFNGRRGPLAVFFMALIIVSLLVYWLnpaaNPLMDL 314
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 504814691 352 MFAlcIANAGLISFPPLFWSM------PTAALGTASvsmgiAVISSVGNLGGFFGPYAVGYLKQLSG 412
Cdd:TIGR00881 315 ICL--FALGFLVYGPQMLIGViaselaPKKAAGTAA-----GFVGFFAYLGGILAGLPLGYLADGFG 374
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
80-420 |
1.36e-17 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 83.78 E-value: 1.36e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 80 LGYVIFEVPSNMLLVRVGPRRWITRIVVSWGIVSGLTALVSTPMQFYVMRFLLGVAEAGFIPAIVLYMARSFPGRRRARI 159
Cdd:cd17473 46 LFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKM 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 160 LSMFYAALALAGLIGSPLTGFILQYfdgamqipGWKWIFILEALpAFLAALYVWKGLDDDVTRSERFSHADRAILARvla 239
Cdd:cd17473 126 LGLQSAAMSLGGVVFLLLGGALAEI--------GWRAPFLVYLL-ALPVLILVLLFLPEPARKSKSAASPGAATAAA--- 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 240 edrataepvnhrglFSNWLVWAFCAIYFLDVFAIYGYTFWAPTMIKQMGIGSDFVIGLLAALPNAVAVVVMVLFGRSADR 319
Cdd:cd17473 194 --------------LPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRR 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 320 RGGRRLHVATLLLMGATGLGLSVVwhDQLWLGMFALCIANAGL-ISFPPLFwSMPTAALGTASVSMGIAVISSVGNLGGF 398
Cdd:cd17473 260 LGKRRLLAIGFALMALGFLLLALA--SGLWVVLLGAILAGLGFgLLLPTLN-SWAMSLVPPELRGRAMGIVTSAFFLGQF 336
|
330 340
....*....|....*....|..
gi 504814691 399 FGPYAVGYLKQLSGNLAAPLFL 420
Cdd:cd17473 337 LSPLVLGPLVNLTGGLSGAFLI 358
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
39-413 |
3.32e-17 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 82.60 E-value: 3.32e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 39 LMFAYVTSYIDRVNVSFAKLQMSQHLGFSDAVFGFGAGIFFLGYVIFEVPSNMLLVRVGPRRWITRIVVSWGIVSGLTAL 118
Cdd:cd17380 4 LFLATCICYADRVNMPIAIVPMAKEFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLLTPL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 119 VSTP--MQFYVMRFLLGVAEAGFIPAIVLYMARSFPGRRRARILSMFYAALALAGLIGSPLTGFILQYFdgamqipGWKW 196
Cdd:cd17380 84 LAYSslPLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYY-------GWPS 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 197 IFILEALPAFLAALYVWkgldddvtrserfshadrailarvlaedrataepvnhrglfsnWLVWAFCAIYFLDVFAIYGY 276
Cdd:cd17380 157 VFYFFGLLGLLWALVWL-------------------------------------------IYLPPVWAIIVAHFCMNWGF 193
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 277 TF---WAPTMIKQmGIGSDFVIGLLAALPNAVAVVVMVLFGRSADRRGGRRLHVATLL-LMGATGLGLSVV------WHD 346
Cdd:cd17380 194 YIllsWLPTYFHE-VLVPLAKGWVFNVVPWLVMFPSSNVAGWLADHLISRGWTVTSVRkLMQSIGFLGPALfllllsHTD 272
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 504814691 347 QLWLGMFALCIAnAGLISFPPLFWSMPTAALGT--ASVSMGIAviSSVGNLGGFFGPYAVGYLKQLSGN 413
Cdd:cd17380 273 SFSLALLCMSVA-LGLSAFSSSGVLVNHQDIAPnyAGIVFGIS--NTAGTIPGIVGVYLTGYILEATGS 338
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
59-421 |
1.14e-14 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 75.28 E-value: 1.14e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 59 QMSQHLGFSDAVFGFGAGIFFLGYVIFEVPSNMLLVRVGPRRWITRIVVSWGIVSGLTALVSTPMQFYVMRFLLGVAEAG 138
Cdd:COG0738 33 ALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALFLLGLGLGL 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 139 FIPAIVLYMARSFPgRRRARILSMFYAALALAGLIGSPLTGFILQYFDGamqiPGWKWIFILEALPAFLAALYVWKgldd 218
Cdd:COG0738 113 LDVAANPYVAALGP-ETAASRLNLLHAFFSLGALLGPLLGGLLILLGLS----LSWHLPYLILAVLLLLLALLFLR---- 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 219 dvtrserfshadRAILARVLAEDRATAEPVNHRGLFSNWLVWAFCAIYFLDVFAIYGYTFWAPTMIKQMGIGSDFVIGLL 298
Cdd:COG0738 184 ------------SKLPEIEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALG 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 299 AALPNAVAVVVMVLFGRSADRRGGRRLhVATLLLMGATGLGLSVVWHdQLWLGMFALCIANAGLISFPPLFWSMPTAALG 378
Cdd:COG0738 252 LSLFWGGMTIGRFLGGFLLKRFGPVRL-LRLSALLAAVGLLLALLAP-GPWLALIGLALVGLGLSLMFPTIFSLALDGLG 329
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 504814691 379 TASvSMGIAVISSVGNLGGFFGPYAVGYLKQLSGNLAAPLFLM 421
Cdd:COG0738 330 KRT-AAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPL 371
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
22-407 |
6.25e-14 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 73.16 E-value: 6.25e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 22 AQEDRIFRRLAVQILPILMFAYVTSYIDRVNVSFAKLQMSQHLGFSDAVFGFGAGIFFLGYVIFEVPSNMLLVRVGPRRW 101
Cdd:TIGR00895 5 NIRKQPLSRYQWRAIILSFLIMLMDGYDLAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRV 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 102 ITRIVVSWGIVSGLTALVSTPMQFYVMRFLLGVAEAGFIPAIVLYMARSFPGRRRARILSMFYAALALAGLIGSPLTGFI 181
Cdd:TIGR00895 85 LLWSILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 182 LQYFdgamqipGWKWIFILEAL-PAFLAAL--------YVWKGLDDDVTRSERFSHADRAILAR---VLAEDRATA--EP 247
Cdd:TIGR00895 165 IPVF-------GWRSLFYVGGIaPLLLLLLlmrflpesIDFLVSKRPETVRRIVNAIAPQMQAEaqsALPEQKSTQgtKR 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 248 VNHRGLFSNWLVWA---FCAIYFLDVFAIYGYTFWAPTMIKQMGiGSDFVIGLLAALPNAVAVVVMVLFGRSADRRGGRr 324
Cdd:TIGR00895 238 SVFKALFQGKTARItvlLWLLYFMLLVGVYFLTNWLPKLMVELG-FSLSLAATGGALFNFGGVIGSIIFGWLADRLGPR- 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 325 lHVATLLLMGATGLGLSVVWHDQLWLGMFALCIA----NAGLISFP---PLFWsmPTAALGTasvsmGIAVISSVGNLGG 397
Cdd:TIGR00895 316 -VTALLLLLGAVFAVLVGSTLFSPTLLLLLGAIAgffvNGGQSGLYalmALFY--PTAIRAT-----GVGWAIGIGRLGA 387
|
410
....*....|
gi 504814691 398 FFGPYAVGYL 407
Cdd:TIGR00895 388 IIGPILAGYL 397
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
125-412 |
1.93e-13 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 71.86 E-value: 1.93e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 125 FYVMRFLLGVAEAGF-IPAIVLYMARSFPGRRRARILSMFYAALALAGLIGSPLTGFILQYFdGAMQIPGWKWIFILEAL 203
Cdd:COG2211 113 ALVTYLLLGLAYTLVnIPYSALGAELTPDYEERTRLSSWRFAFAGLGGLLASVLPPPLVAAF-GGDAALGYRLTALIFAV 191
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 204 PAFLAALYVWKGLDDDVTRSERFSHADRAIlarvlaedrataepvnhRGLFSNWLVWAFCAIYFLDVFAIYGYTFWAPTM 283
Cdd:COG2211 192 LGLLAFLLTFFGTKERPVPEEEKVSLKESL-----------------KALLKNRPFLLLLLAYLLFFLALALVAALLLYY 254
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 284 IKQ-MGIGSDFViGLLAALPNAVAVVVMVLFGRSADRRGGRRLHVATLLLMGATGLGLSVVWHDQLWLGMFALCIANAGL 362
Cdd:COG2211 255 FKYvLGLSAALV-GLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPGNLWLLLVLAALAGIGL 333
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 504814691 363 ISFPPLFWSM-----PTAALGTASVSMGI--AVISSVGNLGGFFGPYAVGYLKQLSG 412
Cdd:COG2211 334 GAILVLPWAMladvvDYDEWKTGRRREGLyfGIFTFAIKLGQALAGALAGLLLALFG 390
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
33-420 |
5.48e-13 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 70.00 E-value: 5.48e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 33 VQILPILMFAYVTSYIDRVNVSFAKLQMSQHLGFSDAVFGFGAGIFFLGYVIFEVPSNMLLVRVGPRRWITRIVVSWGIV 112
Cdd:cd17312 2 WRIFLGVFLGYAAYYVCRKNFSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 113 SGLTALVSTPMQFYVMRFLLGVAE-AGFIPAIVLyMARSFPGRRRARILSMFYAALALAGLIGSPLTGFILQYFdgamqi 191
Cdd:cd17312 82 NIFMGFSTSLWFFAVLWGLNGLFQsMGWPPCVKL-LGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYY------ 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 192 pGWKWIFILEALPAFLAALYVWKGLDDdvtrserfshadrailarvlaedrataepvnhrglfSNWLVWAFCAIYFLDVF 271
Cdd:cd17312 155 -GWRAAFLVPGIVGLVVAIILFFFLRD------------------------------------SPPYVWVLSLAYAFVYI 197
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 272 AIYGYTFWAPTMIKQ-MGIGSDFVIGLLAALPNAVAVVVMVLfGRSADRRGGRRLHVATLLLMGATGLGLSVVWHDQLWL 350
Cdd:cd17312 198 VRYACLDWGPLYLYEvKGYSLIDAGWFSSLYEVGGIAGTILA-GLLSDKLFGGRRAPIAVIYMLLMTLSLALFWFFPHNK 276
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 504814691 351 GMFALCIANAGLISF-PPLFWSMPTAALGTASVSMGIA--VISSVGNLGGFFGPYAVGYLKQLSGNLAAPLFL 420
Cdd:cd17312 277 LLSIVLLFLIGFFVGgPINLIGGAAAQDIGRKEAAGTAtgFVGLFGYLGASLAGLPLGYIIDHYGWSTVFYFL 349
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
35-314 |
6.98e-13 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 69.07 E-value: 6.98e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 35 ILPILMFAYVTSYIDRVNVSFAKLQMSQHLGFSDAVFGFGAGIFFLGYVIFEVPSNMLLVRVGPRRWITRIVVSWGIVSG 114
Cdd:COG0477 15 ALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASL 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 115 LTALVSTPMQFYVMRFLLGVAEAGFIPAIVLYMARSFPGRRRARILSMFYAALALAGLIGSPLTGFILQYFdgamqipGW 194
Cdd:COG0477 95 LCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAAL-------GW 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 195 KWIFILEALPAFLAALYVWKGLDDDVTRSERFSHADRAILARVLAEDRATAEPVNHRGLFSNWLVWAFCAIYFLDVFAIY 274
Cdd:COG0477 168 RWIFLINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLL 247
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 504814691 275 GYTFWAPTMIKQMGIGSDFVIGLLAALPNAVAVVVMVLFG 314
Cdd:COG0477 248 LALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLL 287
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
61-421 |
9.66e-13 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 69.25 E-value: 9.66e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 61 SQHLGFSDAVFGFGAGIFFLGYVIFEVPSNMLLVRVGPRRWITRIVVSWGIVSGLTALVSTPMQFYVMRFLLGVAEAGFI 140
Cdd:cd17371 26 IAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRALAGLGFGGEW 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 141 PAIVLYMARSFPGRRRARILSMFYAALALAGLIGSPLTGFILQYFDGAMqipGWKWIFILEALPAFLAALyvwkgLDDDV 220
Cdd:cd17371 106 AAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAALLFPLLPPEI---AWRVLFLLGALPALLVLF-----IRRFV 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 221 TRSERFShadRAILARVLAEDRATAEPVNHRGLFSNWLVWAFCAIYFLdvFAIYGYTFWAPTMIKQMGIGSDFVIGLLAA 300
Cdd:cd17371 178 KEPPQWQ---AARAARRHFADRPSLRELFSPPLLRTTLLASLLATGAL--GGYYGITTWLPSYLTGERGLSFEGSAGYLV 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 301 LPNAVAVVVMVLFGRSADRRGGRR-------LHVATLLLMGATGLGLSVVWHDQLWLGMFALCIANAGLISFPPLFwsmP 373
Cdd:cd17371 253 VTILGGFLGYLAGGFLADRIGRRNnfalfalGSAISILLYFFLPLSPTLILILGFPLGFFASGPFSGMGAYLTELF---P 329
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 504814691 374 TAALGTasvsmGIAVISSVGNLGGFFGPYAVGYLKQlSGNLAAPLFLM 421
Cdd:cd17371 330 TAVRAT-----AQGFCYNVGRIIGALFPFLVGFLAT-SGSLGTAIAVF 371
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
60-420 |
1.40e-12 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 68.84 E-value: 1.40e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 60 MSQHLGFSDAVFGFGAGIFFLGYVIFEVPSNMLLVRVGPRRWITRIVVSWGIVSGLTALVSTPMQFYVMRFLLGVAEAGF 139
Cdd:cd17355 29 IIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLYLLWGLLGGGGAGT 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 140 IPA-IVLYMARSFPGRRRARILSMFYAALALAGLIGSPLTGFILQYFdgamqipGWKWIFILEALPAFLAALYVWKGLDD 218
Cdd:cd17355 109 LAAvAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAF-------GWRTALLVLALLALLVLVPVLLLLRR 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 219 DVtrserfshADRAILARVLAEDRATAEPVnhRGLFSNWLVWAFCAIYFLDVFAIYGYTFWAPTMIKQMGIGSdFVIGLL 298
Cdd:cd17355 182 RP--------ADLALRAYDDASPASPGSTL--KEALRSASFWLLALAFFLCGFAVVGLIVHLVPYLADRGISP-AAAAVA 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 299 AALPNAVAVVVMVLFGRSADRRGGRRLHVATLLLMGATGLGLSVVWHDQLWLGMFALCIANAGLISFPplfwsmPTAAL- 377
Cdd:cd17355 251 LALIGLFNIVGRLLSGWLGDRYSPRRLLAASYALRALGLALLLLLPFPPLALLLFAALFGLGWGATVP------LTAALa 324
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 504814691 378 ----GTASVSMGIAVISSVGNLGGFFGPYAVGYLKQLSGNLAAPLFL 420
Cdd:cd17355 325 aryfGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGSYTAAWAL 371
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
36-407 |
2.59e-12 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 67.61 E-value: 2.59e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 36 LPILMFAYVTSYIDRVNVSFAKLQMSQHLGFSDAVFGFGAGIFFLGYVIFEVPSNMLLVRVGPRRWITRIVVSWGIVSGL 115
Cdd:cd17365 1 LALCFLIIVLDGFDLAVMGFVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 116 TALVSTPMQFYVMRFLLGVAEAGFIPAIVLYMARSFPGRRRARILSMFYAALALAGLIGSPLTGFILQYFdgamqipGWK 195
Cdd:cd17365 81 TAFAQSVLQLALLRFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAF-------GWR 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 196 WIFILEALPAFLAALYVWKGLdddvtrserfshadrailarvlaedrataepvnhrglfsnwlvwAFCAIYFLDVFAIYG 275
Cdd:cd17365 154 SVFLLGGVPPLILLPLLRGTL--------------------------------------------LLWVTFFMGLLLVYL 189
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 276 YTFWAPTMIKQMGIGSDFVIGLLAALpNAVAVVVMVLFGRSADRRGGRRLHVATLLLMGATGLGLSVVWHDQLWLGMFAL 355
Cdd:cd17365 190 LNSWLPKLMVEAGYSLSQALTITLLL-NIGGVIGSLLLGWLADRFGPKRVLALFFALGAVSLALLGVSPASLVLLYVLVF 268
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 504814691 356 CI------ANAGLISFPPLFWsmPTAALGTasvsmGIAVISSVGNLGGFFGPYAVGYL 407
Cdd:cd17365 269 LAgacvngAQVGLYALAARFY--PTEVRAT-----GVGWALGVGRLGAILGPLLGGLL 319
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
60-400 |
5.63e-12 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 66.81 E-value: 5.63e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 60 MSQHLGFSDAVFGFGAGIFFLGYVIFEVPSNMLLVRVGPRRWITRIVVSWGIVSGLTALVSTPMQFYVMRFLLGVAEAGF 139
Cdd:cd17321 22 IARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAARALQGIGAAAI 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 140 IPAIVLYMARSFPGRRRARILSMFYAALALAGLIGSPLTGFILQYFdgamqipGWKWIFILEALPAFLAalyvwkglddd 219
Cdd:cd17321 102 MPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELF-------GWRWIFLINVPIGLVA----------- 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 220 vtrserfshadrAILARvlaedrataepvnhrglfsnwLVWAFCAIYFLDVFAIYGYTFWAPTMIKQMGIGSDFVIGlLA 299
Cdd:cd17321 164 ------------LLLAR---------------------TFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAG-LA 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 300 ALPNAVAVVVM-VLFGRSADRRGGRRLHVATLLLMGATGLGLSVVWHDQLWLGMFALCI-ANAGLISFPPLFWSMPTAAL 377
Cdd:cd17321 210 LLPLALAMLVAaPLAGRLADRFGPRLVLVAGLLLTAVGLLLLALLGADSSVWLLLPGLVlLGLGLGLFATPLTNAALSSV 289
|
330 340
....*....|....*....|...
gi 504814691 378 GTASVSMGIAVISSVGNLGGFFG 400
Cdd:cd17321 290 PKEKAGAASGILNTARQLGGALG 312
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
59-420 |
3.19e-11 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 64.63 E-value: 3.19e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 59 QMSQHLGFSDAVFGFGAGIFFLGYVIFEVPSNMLLVRVGPRRWITRIVVSWGIVSGLTALVSTPMQFYVMRFLLGVAEAG 138
Cdd:cd06180 24 LMLAELGLSYAQAGWIATANYAGYLVGALLASFLRRRGRARRLIRGGLLLTVLLLAAMALTSGFAALLALRFLAGAASAF 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 139 FIPAIVLYMARSFPGRRRARILSMFYAALALAGLIGSPLTGFILQYFDgamqipGWKWIFILEALPAFLAALYVWkgldd 218
Cdd:cd06180 104 VFVFGSNLVLHHATAAGRGHLIGLLFAGVGLGIALSGLLVPAGLGGGL------SWRAGWLALALLSAVLLLLSF----- 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 219 dvtrserfshadraiLARVLAEDRATAEPVNHRGLFSNWLVWAFCAIYFLDVFAIYGYTFWAPTMIKQMGIGSdFVIGLL 298
Cdd:cd06180 173 ---------------LLLRRGPSAPTEASAAESAPGLNRPLWRLALAYGLFGFGYIITATFLPLIARETGAGS-LLAGLL 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 299 AALPNAVAVVVMVLFGRSADRRGGRRLhVATLLLMGATGLGLSVVWHDQLWLgmfALCIANAGLISFPPLFWSMPTA-AL 377
Cdd:cd06180 237 WSLFGLAAVPSCFLWGALSDRWGTRRA-LAANLLVQAVGVLLPLLSPGPAGL---VLSAVLFGGTFMAITALVMALArEL 312
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 504814691 378 GTASVSMGIAVISSVGNLGGFFGPYAVGYLKQLSGNLAAPLFL 420
Cdd:cd06180 313 APPAAPRALALMTASFGVGQILGPLLAGWLADATGGFAPALIL 355
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
58-412 |
3.35e-11 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 64.58 E-value: 3.35e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 58 LQMSQHLGFSDAVFGFGAGIFFLGYVIFEVPSNMLLVRVGPRRW-ITRIVVSWGIVSGLTALVSTPMQFYVMRFLLGVAE 136
Cdd:cd17341 23 PVIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVfIASLLLLLIPLLALALAVSSYWGLLVLGFLLGFAG 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 137 AGFIPAIVlYMARSFPGRRRaRILSMFYAAlalAGLIGSPLTGFILQYFDGAMQIP----GWKWIFILEALPAFLAALYV 212
Cdd:cd17341 103 ANFASGQP-WASFWFPKEKI-GGAAGGIAG---AGNMGVAVSQLLAPLIAGAIVFDggfvGWRNAFFVPGILLAIAAVLV 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 213 WKGLDDDVTRSERFSHADRAILARvlaedrataepvnhrglFSNWLVWAFCAIYFLDVFAIYGYTFWAPTMIKQMGIGSD 292
Cdd:cd17341 178 LLFGDDLPTGKASALEFLKVQLAV-----------------LKNYRTWILSLLYGVTFGSFVGFSNVLPTYFKTRFGLPL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 293 FVIGLLAALPNAVAVVVMVLFGRSADRRGGRRLHVATLLLMGATGLGLSvvWHDQLWLGMFALCIANAGLIS------FP 366
Cdd:cd17341 241 VTAGILAALFPLAGALARPAGGWLSDRFGGRRRLWWLFIVMTIGAALLS--LSLPTSGTNLVLFLALFVALGlgagagNG 318
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 504814691 367 PLFWSMPTAALGTASVSMGIavISSVGNLGGFFGPYAVGYLKQLSG 412
Cdd:cd17341 319 SVFRMVPFIFRRELGAVTGL--VGAIGGLGGFFLPLLFGSSALMTG 362
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
55-406 |
3.77e-11 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 64.17 E-value: 3.77e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 55 FAKLQMSQHLGFSDAVFGFGAGIFFLGYVIFEVPSNMLLVRVGPRRWITRIVVSWGIVSGLTALVSTPMQFYVMRFLLGV 134
Cdd:cd17329 21 FMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGF 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 135 AEAGFIPAIVLYMARSFPGRRRARILSMFYAALALAGLIGSPLTGFILQYfdgamqipGWKWIFILEALPAFLAALYVWK 214
Cdd:cd17329 101 GGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLY--------SFRLLFLAAAVLFLLAALVLLF 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 215 GLDDDVTRSERFSHADRAILARVLAEDRAtaepvnhrglfsnwlVWAFCAIYFLDVFAIYGYTFWAPTMIKQMGIGSDFV 294
Cdd:cd17329 173 LLPETRPKRRAAEKTEILRGYKIVLRDRA---------------FLLFLLASFLISLIYFQLESTLPVYVVEILGLGESL 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 295 IGLLAALPNAVAVVVMVLFGRSADRRGGRRLHVATLLLMGAtGLGLSVVWHDQLWLGMFALCIANAGLISFPP----LFW 370
Cdd:cd17329 238 LGLLLALNALLIVLLQFPVARLVERFRLRKILMIGILLFAI-GFAVLAFANTLAVLILAMIVLTLGEMLVFPAvqtlVAA 316
|
330 340 350
....*....|....*....|....*....|....*...
gi 504814691 371 SMPTAALGT--ASVSMGIAVISSVGNLGGFFGPYAVGY 406
Cdd:cd17329 317 LAPPDKRGSymGFYALAWGLGRAIGPLVGGLLLDLLGP 354
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
62-412 |
4.75e-11 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 64.15 E-value: 4.75e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 62 QHLGFSDAVFGFGAGIFFLGYVIFEVPSNMLLVRVGPRRWITRIVVSWGIVSGLTALVSTPMQFYVMRFLLGVAEAGFIP 141
Cdd:cd17489 24 HDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTT 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 142 AIVLYMARSFPGRRRARILSMFYAALALAGLIGSPLTGFILQYFDGAMQIpgwkWIFILEALPAFLAALYVWKGLDDDVT 221
Cdd:cd17489 104 AAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLF----IVAAVLALLALLLVFLVKDPPPVAAE 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 222 RSERFSHADRAILARVlaedrataepvnhrglfsnwlVWAFCAIYFLDVFAIYGYTFWAPTMIKQMGIGSDFVIGLLAAL 301
Cdd:cd17489 180 EAEAGTRAFRRLVEKK---------------------VLPPALILFLASIAYGAISTFLPLYAAERGISNAGLFFTVYAI 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 302 pnaVAVVVMVLFGRSADRRGGRRLHVATLLLMGATGLGLSVVwhDQLWLGMFALCIANAGLISFPPLFWSMPTAALGTAS 381
Cdd:cd17489 239 ---ALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFA--GSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHR 313
|
330 340 350
....*....|....*....|....*....|.
gi 504814691 382 VSMGIAVISSVGNLGGFFGPYAVGYLKQLSG 412
Cdd:cd17489 314 RGAANGTFFIFFDLGIGLGGLLLGLVAELFG 344
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
59-412 |
3.87e-09 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 57.97 E-value: 3.87e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 59 QMSQHLGFSDAVFGFGAGIFFLGYVIFEVPSNMLLVRVGPRRWITRIVVSWGIVSGLTALVSTPMQFYVMRFLLGVAEAG 138
Cdd:cd17474 24 AIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALQGIGAAG 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 139 FIPAIVLYMARSFPGRRRARILSMFYAALALaGLIGSPLTGFILQYFDgamqipgWKWIFILEALPAFLAALYVWKGLDD 218
Cdd:cd17474 104 LGPLALTLIGDLFEGGERAKAMGLYEAALGL-GIAVGPLLGGLLAAIS-------WRYPFFLLAALIPVAFLAILFLLPE 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 219 DVTRSERFSHADRAILARVLaedrataepvNHRGLFSNwLVWAFCAIYFLdvfaiYGYTFWAPTMIKQMGIGSDFVIGLL 298
Cdd:cd17474 176 PKEKAKSSSATKLRDLKKAL----------RGRGLLTF-LVSAFLYFFLY-----FAFLTYLPFLLELLYGISPIIIGLL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 299 AALPNAVAVVVMVLFGR-SADRRGGRRLHVATLLLMGAtGLGLSVVWHDQLWLGMFALcIANAGLISFPPLFWSMPTAAL 377
Cdd:cd17474 240 FAGWSVLLALGSLFVGRlLKKRFGARRILVIGLLLYAL-SLLLLGFVPSLALLLIAIV-LFGLGLGLNLPLLTTLVTELA 317
|
330 340 350
....*....|....*....|....*....|....*
gi 504814691 378 GTASVSMGIAVISSVGNLGGFFGPYAVGYLKQLSG 412
Cdd:cd17474 318 PEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFG 352
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
60-420 |
5.31e-09 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 57.63 E-value: 5.31e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 60 MSQHLGFSDAVFGFGAGIFFLGYVIFEVPSNMLLVRVGPRRWITRIVVSWGIVSGLTALVSTPMQFYVMRFLLGVAEAGF 139
Cdd:cd17475 22 LQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLVGAGYGSV 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 140 IPAIVLYMARSFPGRRRARILSMFYAALALAGLIGSPLTGFILQYFdgamqipGWKWIFILEALPAFLAALYVWKGLddd 219
Cdd:cd17475 102 QPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHY-------GWRAAFVVAGLVSILAAVLFWLFY--- 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 220 vtrserfshadRAILARVLAEDRATAEPVNHRGLFSNWLVWAFCAIYFLDVFAIYGY-TFWAPTMIKQMGIgSDFVIGLL 298
Cdd:cd17475 172 -----------REPPAASAATESASTLLRSLKEVLRNRDVWLIAIAGALLVAPQFALlTFLLLFLHDHLGL-SVVAAGAL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 299 AALPNAVAVVVMVLFGRSADR-RGGRRLHVatLLLMGATGLGLSVV-----WHDQLWLGMFALCIANAGLISFPPLFWSM 372
Cdd:cd17475 240 LAVAQLGGALGRIGLGRVSDRvFGGRRRPV--LVITAAIAAAALLVlsllsPGTPLWLLVLLLILLGLFAIGWNGLYLTL 317
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 504814691 373 PTAALGTASVSMGIAVISSVGNLGGFFGPYAVGYLKQLSGNLAAPLFL 420
Cdd:cd17475 318 VAESAGPEQAGTALGLANTINFIGIAIGPPLFGLLVDATHSYAPAWLA 365
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
60-213 |
1.32e-08 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 56.43 E-value: 1.32e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 60 MSQHLGFSDAVFGFGAGIFFLGYVIFEVPSNMLLVRVGPRRWITRIVVSWGIVSGLTALVSTPMQFYVMRFLLGVAEAGF 139
Cdd:cd17325 226 AAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLV 305
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 504814691 140 IPAIVLYMARSFPGRRRARILSMFYAALALAGLIGSPLTGFILQYFdgamqipGWKWIFILEALPAFLAALYVW 213
Cdd:cd17325 306 FPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAF-------GFATPFLAAAALLLLAAVLFL 372
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
59-407 |
3.54e-08 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 55.27 E-value: 3.54e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 59 QMSQHLGFSDAVFGFGAGIFFLGYVIFEVPSNMLLVRVGpRRWITRIVVSWGIVSGL-TALVSTPMQFYVMRFLLGVAeA 137
Cdd:cd17320 24 AIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFG-RRPVLLAGLLLFILASLlCALASSIEQLLIARFLQGLG-A 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 138 GFIPAIVLYMAR-SFPGRRRARILSMFYAALALAGLIGSPLTGFILQYFdgamqipGWKWIFILEALPAFLAALYVWKGL 216
Cdd:cd17320 102 AAGSVVARAIVRdLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFF-------GWRAIFVFLALLGLLLLLLVLLFL 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 217 dddvtrSERFSHADRAILARVLAEdrataepvNHRGLFSNWLVWAFCAIYFLDVFAIYGYTFWAPTMIKQMGIGSDFVIG 296
Cdd:cd17320 175 ------PETLPEEKRKPLLSSLLR--------AYKRVLKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 297 LLAALPNAVAVVVMVLFGRSADRRGGRRLHVATLLLMGATGLGLSVVWHDQ------LWLGMFALCIANAglISFPPLFW 370
Cdd:cd17320 241 LLFALNAIALILGSLLNGRLVRRFGPRRLLRLGLLLLLAAALVLLLAALLGglslwpLVAPLFLIFFGFG--LIFPNATS 318
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 504814691 371 SM----PTAAlGTASvsmgiAVISSVGNLGGFFGPYAVGYL 407
Cdd:cd17320 319 LAlepfPHVA-GTAS-----ALLGFLQFLIGALAGALVGLL 353
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
76-365 |
4.93e-08 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 54.48 E-value: 4.93e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 76 GIFFLGYVIFEVPSNMLLVRV----GPRRWITRIVVSWGIVS-GLTALVSTPMQ-FYVMRFLLGVAEAGFipAIVLYMAR 149
Cdd:cd17471 35 GIFMTLSALSGIVVSQWLGRLsdrgGDRKPLILLALLAGALGyLLFAFLRNYWVlLLVGVVLLSLGAAAF--PQLFALAR 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 150 SF----PGRRRARILSMFYAALALAGLIGSPLTGFILQYFdgamqipGWKWIFILEALPAFLAALYVWKGLDDDvtrser 225
Cdd:cd17471 113 EYadrsSGRDATLFNSVLRAAFSLAWVIGPPLAFLLLDVL-------GFTGLFLLAALLYLVVALLVLFLLPSV------ 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 226 fshadrailaRVLAEDRATAEPVNHRGLfsNWLVWAFCAIYFLDVFAIYGYTFWAPTMIKQMGIGSDFVIGLLAALPNAV 305
Cdd:cd17471 180 ----------KPPAQKATPASSLVKAPV--NRRLLLLFAAFTLLFAANSMYIIAMPLYVTNELGGSESWVGLLFGLAAAL 247
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 306 AVVVMVLFGRSADRRGGRRLHVATLLLmgATGLGLSVVWHDQLWlGMFALCIANAGLISF 365
Cdd:cd17471 248 EIPIMLLAGLLAKRFGKRRLLLAGFLA--GVLFYLGLALATSLW-QLIALQLLNAIFIGI 304
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
129-400 |
5.29e-08 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 54.50 E-value: 5.29e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 129 RFLLGVAEAGFIPAIVLYMARSFPGRRRARILSMFYAALALAGLIGSPLTGFILQYFdgamqipGWKWIFILEALPAFLA 208
Cdd:cd17503 91 RILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNL-------SWRWIFYINLPIGILA 163
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 209 ALYVwkgldddvtrserfshadrailarvlaedrataePVNHRGLFSNWLVWAFCAIYFLDVFAIYGYTFWAPTMIkQMG 288
Cdd:cd17503 164 LLLA----------------------------------PLLDLRLFKDRNFTLGLLLSFLLGLGLFGAMFLLPLYL-QNV 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 289 IG-SDFVIGLLAALPNAVAVVVMVLFGRSADRRGGRRLHVATLLLMGATGLGLSVVWHDQ-LWLGMFALCIANAGL-ISF 365
Cdd:cd17503 209 LGySAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGLLLLALGTLLLAFLTPDTsLWLIILPLFIRGLGMgLVF 288
|
250 260 270
....*....|....*....|....*....|....*
gi 504814691 366 PPLFwSMPTAALGTASVSMGIAVISSVGNLGGFFG 400
Cdd:cd17503 289 MPLN-TLALNSLPPEQIGDATALFNTIRQLGGSIG 322
|
|
| MFS_NIMT_CynX_like |
cd17339 |
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator ... |
59-421 |
6.48e-08 |
|
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli 2-nitroimidazole transporter (NIMT) and cyanate transport protein CynX, and similar proteins. NIMT, also called YeaN, confers resistance to 2-nitroimidazole, the antibacterial and antifungal antibiotic, by mediating the active efflux of this compound. CynX is part of an active transport system that transports exogenous cyanate into E. coli cells. The NIMT/CynX-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340897 [Multi-domain] Cd Length: 374 Bit Score: 54.12 E-value: 6.48e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 59 QMSQHLGFSDAVFGFGAGIFFLGYVIFEVPSNMLLVRVGPRRWITRIVVSWGIVSGLTALVSTPMqFYVMRFLLGVAEAG 138
Cdd:cd17339 24 EIRDDLGLSASQAGLLTTLPLLCFAVFSPLAPRLARRFGLERTLLLALLLLAAGILLRSLGGIAL-LFLGTALAGAGIAV 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 139 ---FIPAIVlymARSFPgRRRARILSMFYAALALAGLIGSPLTGFILQYFDGamqipGWKWIFILEALPAFLAALyVWkg 215
Cdd:cd17339 103 gnvLLPSLI---KRDFP-RRVGLMTGLYTTSMNLGAALASGLSVPLAQALGG-----GWRGALAIWALPALLALL-IW-- 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 216 ldddvtrserfshadrAILARVLAEDRATAEPVNHRGLFSNWLVWAFcAIYF-LDVFAIYGYTFWAPTMIKQMGIGSDFV 294
Cdd:cd17339 171 ----------------LPQLRRRKRAAAAAAPLTKISVWRSPLAWQV-TLFMgLQSLLFYTLMAWLPTILIDAGLSAATA 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 295 iGLLAALPNAVAVVVMVLFGRSADRRGGRRLHVATLLLMGATG-LGLSVVWHDQLWLGMFALCIANAGLISFPPLFWSMP 373
Cdd:cd17339 234 -GWLLSLFQLVGIPASLLVPILATRLKNQRPIVVLLAVLFIIGvLGLLFAPTALALLWAVLLGLGGGAAFSLALTLISLR 312
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 504814691 374 TA-ALGTASVSmgiAVISSVGNLGGFFGPYAVGYLKQLSGNLAAPLFLM 421
Cdd:cd17339 313 SSdPAEAAALS---GMAQSVGYLLAALGPLLFGVLHDLTGSWTAPLVLL 358
|
|
| 2A0114euk |
TIGR00894 |
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions] |
78-414 |
1.03e-07 |
|
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
Pssm-ID: 129972 [Multi-domain] Cd Length: 465 Bit Score: 53.98 E-value: 1.03e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 78 FFLGYVIFEVPSNMLLVRVgPRRWITRIVVSWGIVSGLTALVSTPMQF---YVMRFLLGVAEAGFIPAIVLYMARSFPGR 154
Cdd:TIGR00894 85 HFYGQIIIQIPVGYLAGKY-VFKWSIGIGMFLSSVISIVIPWAAGGGIalvVFCRVIQGLAQGSVSPATHKIIVKWAPPK 163
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 155 RRARILSMFYAALALAGLIGSPLTGFILQYFdgamqiPGWKWIFILEALPAFLAALYVWKGLDDDVTRSERFSHADRA-I 233
Cdd:TIGR00894 164 ERSRLLGMSTSGFQLGTFIFLPISGWLCESW------GGWPMIFYVFGIVGCAWSLLWFVFPADDPSIHPCISKFEKKyI 237
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 234 LARVLAEDRATAEPVNHRGLFSNWLVWAFcaiyfldVFAIYGYTF-------WAPTMIKQMGIGSDFVIGLLAALPNAVA 306
Cdd:TIGR00894 238 NSSLQGQKGSTRQSLPIKAIPKSLPVWAI-------WFAIFGHFWlytilptYLPTFISWVLRVSGKENGLLSSLPYLFA 310
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 307 VVVMVLFGRSAD---RRGGRRLHVATLLLMGATGLGLSVVWHDQLWLG------MFALCIANAgLISFPplFWSMPTAAL 377
Cdd:TIGR00894 311 WLCSIFAGYLADflkSSKTLSLTAARKIFNGIGGLGPGIFAYALPYLSaafyltIIILTLANA-VSSGP--LAGVLINSL 387
|
330 340 350
....*....|....*....|....*....|....*..
gi 504814691 378 GTASVSMGIavISSVGNLGGFFGPYAVGylkQLSGNL 414
Cdd:TIGR00894 388 DLAPRFLGF--IKGITGLPGFIGGLIAS---TLAGNI 419
|
|
| MFS_MosC_like |
cd17393 |
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ... |
62-421 |
3.78e-07 |
|
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340951 [Multi-domain] Cd Length: 373 Bit Score: 51.88 E-value: 3.78e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 62 QHLGFSDAVFGFGAGIFFLGYVIFEVPSNMLLVRVGPRRWITRIVVSWGIVSGLTALVSTPMQFYVMRFLLGVAeAGFIP 141
Cdd:cd17393 27 DRLGLSDAALGLLLLALGVGALVAMPLAGRLVARFGSRRVTRLGALLLLLALLLLGLAPSVPALALALFLFGAA-NGALD 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 142 AIVLYMARSFPGRRRARILSMFYAALALAGLIGSpLTGFILQYFDGAMQipgwkWIFILEALPAFLAALYVWKGLDDDvt 221
Cdd:cd17393 106 VAMNAQGVAVERAYGRPIMSSLHAMWSLGGLAGA-LLGAAAIGAGVSPG-----VHLLAAAVLLLLAALVAIRALLPG-- 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 222 rserfshadrailaRVLAEDRATAEPVNHRGLFSNWLVWAFCAIYFLDVFAIYGYTFWAPTMIKQMGIGSDFVIGLLAAL 301
Cdd:cd17393 178 --------------TGEAAEDRPDGAGKPGFLLPNRLLLLLGLLALAAALAEGAAADWSALYLRDVLGASAALAALGYAV 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 302 pNAVAVVVMVLFGRSADRRGGRRLHVATLLLMGATGLGLSVVwHDQLWLGMFALCIANAGLISFPPLFWSMpTAALGTAS 381
Cdd:cd17393 244 -FSLAMTVGRLFGDRLVDRFGDVAVLRAGALLAALGLLLALL-APSVWVALAGFALMGLGLSVVVPLAFSA-AGALPGLA 320
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 504814691 382 VSMGIAVISSVGNLGGFFGPYAVGYLKQLSGNLAAPLFLM 421
Cdd:cd17393 321 AGIAVARVATLGYLGFLVGPPLIGFLADATGLRTAFLVVA 360
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
62-412 |
4.56e-07 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 51.45 E-value: 4.56e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 62 QHLGFSDAVFGFGAGIFFLGYVIFEVPSNMLLVRVGPRRWITRI-----VVSWGIVsgltALVSTPMQFYVMRFLLGVAE 136
Cdd:cd17490 24 ESLGASLSMIGIILGAYGISQMLLRIPLGILSDRIGKRKLFIIIgllftVLASLIM----ILFPSPWGLLIARFLSGIAA 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 137 AGFIPAIVLYmARSFPGRRRARILSMFYAALALAGLIGSPLTGFILQYFdgamqipGWKWIFILEALPAFLAalyvwkgl 216
Cdd:cd17490 100 ATWVSFTVLY-ASYFPPDEAAKAMGLINLVNNLGQLIAFLIGGLIAEHF-------GMRAPFLLAALAGVLG-------- 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 217 dddvtrserfshadrAILARVLAEDRATAEPVNHRG-----LFSNWLVWAFCAIYFLDVFAIYGYTF-WAPTMIKQMGiG 290
Cdd:cd17490 164 ---------------FILSLFIKEERREKKPVLTELkellsVLKDKKLLFFSLLAILQQMITFSTTFgFTPLIAKQLG-A 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 291 SDFVIGLLAALPNAVAVVVMVLFGRSADRRGGRRLHVATLLLMGATGLGLsVVWHDQLWLGMFALCIANAGL-ISFPPL- 368
Cdd:cd17490 228 SSFQLGLLSIIYLLPNALASLLSGTLFYKKLGERNTIIIGFLLLGAYCFL-IPFAPNLTLLYLLQALNGFGTgILFPLLm 306
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 504814691 369 FWSMPTAALGTASVSMGIavISSVGNLGGFFGPYAVGYLKQLSG 412
Cdd:cd17490 307 SLSIEGVPAEQRSTAMGF--FQAIYALGMFLGPVLVGIISEAFG 348
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
115-213 |
1.40e-06 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 47.64 E-value: 1.40e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 115 LTALVSTPMQFYVMRFLLGVAEAGFIPAIVLYMARSFPGRRRARILSMFYAALALAGLIGSPLTGFILQYFdgamqipGW 194
Cdd:TIGR00880 44 MFALSSNITVLIIARFLQGFGAAFALVAGAALIADIYPPEERGVALGLMSAGIALGPLLGPPLGGVLAQFL-------GW 116
|
90
....*....|....*....
gi 504814691 195 KWIFILEALPAFLAALYVW 213
Cdd:TIGR00880 117 RAPFLFLAILALAAFILLA 135
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
38-407 |
1.66e-06 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 49.92 E-value: 1.66e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 38 ILMFAYVTSYIDRVNVSFAKLQMSQH----------------------LGFSDAVFGFGAGIFFLGYVIFEVPSNMLLVR 95
Cdd:cd17318 3 LLFLGFAVVYAMRVNLSVAIVAMVNStathdnnntstdkdtlpveapeFDWSEKTQGIILSSFFYGYILTQIPGGYLAEK 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 96 VGprrwiTRIVVSWGIVSG--LTAL--VSTPMQFY---VMRFLLGVAEAGFIPAIVLYMARSFPGRRRARILSMFYAALA 168
Cdd:cd17318 83 YG-----AKRVLGYSILITalLTLLtpLAARGGYGaliVLRILQGLAQGVTFPAMHALWAKWAPPLERSRLTSIAYSGSQ 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 169 LAGLIGSPLTGFILQYFdgamqipGWKWIFILEALPAFLAALYVWkgldddvtrserfshadRAILArvlaedrataepv 248
Cdd:cd17318 158 FGTVIAMPLSGFLCESL-------GWPSIFYIFGGLGLLWCLLWF-----------------FLVLP------------- 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 249 nhrglfsnwlVWAFCAIYFLDVFAIYGYTFWAPTMIKQ---MGIGSDfviGLLAALPNAVAVVVMVLFGRSAD---RRGG 322
Cdd:cd17318 201 ----------VWAIVVAHFGHNWGFYTLLTELPTYMSDvlhFNIKSN---GFLSSLPYLAMWICSIVGGYLADwlrSRGI 267
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 323 RRL----HVATLLLMGATGLGLSVVWH--DQLWLGMFALCIAnaglISFPPLFWSMPTA-----ALGTASVSMGIAviSS 391
Cdd:cd17318 268 LSTttvrKLFTSIGFLGPGVFLIALGYlgSNATLAVVFLTLS----VGLSGACYSGFLVnhldlAPNYAGTLMGIT--NT 341
|
410
....*....|....*.
gi 504814691 392 VGNLGGFFGPYAVGYL 407
Cdd:cd17318 342 AATIAGIISPLIVGAI 357
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
257-412 |
3.17e-06 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 48.82 E-value: 3.17e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 257 WLVWAFCAIYFLDVFAIYGYTFWAPTMIKQMGIgSDFVIGLLAALPNAVAVVVMVLFGRSADRRGGRRLHVATLLLMGAT 336
Cdd:COG2814 10 LALLALALGAFLSGLGIGIVLPALPLIAADLGA-SPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALG 88
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 504814691 337 GLGLSVVWHdqLWLGMFALCIANAGLISFPPLFWSMPTAALGTASVSMGIAVISSVGNLGGFFGPYAVGYLKQLSG 412
Cdd:COG2814 89 SLLCALAPS--LWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFG 162
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
95-216 |
9.48e-06 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 47.64 E-value: 9.48e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 95 RVGPRRWITRIVVSWGIVSGLTALVSTPMQFYVMRFLLGVAEAGFIPAIVLYMARSFPGRRRARILSMFYAALALAGLIG 174
Cdd:cd17391 266 RIGHHRILLGALLASALLYIPQAFVQTPWQLGILRFLLGLATGGLLPAINSLLAKITPKEVAGRIFGYNQSFQYLGNVAG 345
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 504814691 175 SPLTGFILQYFdgamqipGWKWIFILEALPAFLAALYVWKGL 216
Cdd:cd17391 346 PLLGSAIAAHF-------GYRAVFVVTALLVLLNAIWSFIFL 380
|
|
| 2A0108 |
TIGR00886 |
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions] |
61-397 |
1.10e-05 |
|
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]
Pssm-ID: 273322 [Multi-domain] Cd Length: 354 Bit Score: 47.30 E-value: 1.10e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 61 SQHLGFSDAVFGFGAGIFFLGYVIFEVPSNMLLVRVGPRRWITRIVVSWGIVSGLTALVSTPM-QFYVMRFLLGVAEAGF 139
Cdd:TIGR00886 29 KDDLGLSTAQLGNLVAVPVLAGAVLRIILGFLVDIFGPRYTTALSLLLLAIPCLWAGLAVQSYsVLLLIRLFIGIAGGSF 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 140 IPAIVLyMARSFPGRRRARILSMfYAAL-----ALAGLIGSPLTGFILQ-YFDGAMQIPGWKWIFILEALPAFLAALYVW 213
Cdd:TIGR00886 109 ASCMPW-ISFFFPKKIQGTALGL-AAGWgnmggGVAQFVMPPIIGSLIFgGGQPAHLAWGWAFVIVPAGILLLPALLIFF 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 214 KGLDDDVTRSerfshadrailarvlAEDRATAEPVNHRGLFSNwlVWAFCAIYFLDVFAIYGYTFWAPTMIKQMGIGSDF 293
Cdd:TIGR00886 187 VGADTPPGKP---------------ATGKLSFKEALKVFGNRH--TWILALLYSVTFGSFLGVSSIFAMLFKDQFGLSKV 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 294 VIGLLAALPNAVAVVVMVLFGRSADRRGGRR--LHVATLLLMGATGLGLSVVWHDQLWLGM-------FALCIANAGLIS 364
Cdd:TIGR00886 250 QAGAYASLGGFLGSLARPAGGAISDRLGGARklLMNFLGVAMGAFLVVLGLVSDGSLAAFIvlfvalfFFAGAGNGSTFA 329
|
330 340 350
....*....|....*....|....*....|...
gi 504814691 365 FPPLFWSMPTAAlgtasvsmGIAVISSVGNLGG 397
Cdd:TIGR00886 330 LVPHIFRRATGA--------VSGLIGAIGNLGG 354
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
110-408 |
1.11e-05 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 47.65 E-value: 1.11e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 110 GIVSGLTALVSTPMQFYVMRFLLGVAEAGFIPAIVLYMARSFPGRRRARILSMFYAALALAGLIGSpLTGFILQYFDGAM 189
Cdd:pfam00083 90 AVLQGAAKGKWSVYQLIVGRVLVGIGVGGASVLAPMYISEIAPKKLRGALGSLYQLAITFGILLAY-IFGLGLNKTSNSD 168
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 190 qipGWKWIFILEALPAFLAAL-----------YVWKGLDDDVTRSERFSH----ADRAILARVLAEDRA-TAEPVNHRGL 253
Cdd:pfam00083 169 ---GWRIPLGLQLVPALLLIIgllflpesprwLVEKGRLEEAREVLAKLRgvpdVDRELDEIKDSLEAGqEAEKASWKEL 245
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 254 FSNW------LVWAFCAIY--FLDVFAIYGYtfwAPTMIKQMGIGSDFVIGLLAALPNAVAVVVMVLFgrsADRRGGRRL 325
Cdd:pfam00083 246 FSTKtrrqrlLIGVMLQIFqqLTGINAIFYY---STTIFENLGLSDSFLVTIIVGVVNFVFTFIAIFL---VDRFGRRPL 319
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 326 HVATLLLMGATGLGLSVVWHDQL----WLGM---FALCIANAG-LISFPPLFWSMPT--AALGTASVSMGIAVISS-VGN 394
Cdd:pfam00083 320 LLLGAAGMAICFVILGIVALLGVsksdWAGIvaiVFIALFIAFfAMGWGPVPWVIVSelFPLSVRSKAMALATAANwLAN 399
|
330
....*....|....*
gi 504814691 395 -LGGFFGPYAVGYLK 408
Cdd:pfam00083 400 fLIGFLFPIITDAIG 414
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
64-365 |
1.55e-05 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 46.84 E-value: 1.55e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 64 LGFSDAVFGFGAGIFFLGYVIFEVPSNMLLVRVGPRRW-----ITRIVVSWGIVSGLTALVSTPMQFYVMRFLLGVAEAG 138
Cdd:cd06173 29 LTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLliladLLRALLAAVLALLALLGSLSLWLLLVLAFLLGIASAF 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 139 FIPAIVLYMARSFPGRRRARILSMFYAALALAGLIGSPLTGFILQYFdgamqipGWKWIFILEALPAFLAALyvwkgldd 218
Cdd:cd06173 109 FGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALL-------GPGGAFAINALSFLLSAL-------- 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 219 dVTRSERFSHADRAILARVLAEDRATAEpvnHRGLFSNWLVWAFCAIYFLDVFAIYGYTFWAPTMIKQMGIGSDFVIGLL 298
Cdd:cd06173 174 -LLLFIRRPPPAAPGESSSLLLRDLREG---LRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLL 249
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 504814691 299 AALPNAVAVVVMVLFGRSADRRGGRRLHVATLLLMGATGLGLSVVWhdQLWLGMFALCIANAGLISF 365
Cdd:cd06173 250 LAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSP--SLWLLLAALFLLGLAGGLF 314
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
62-214 |
1.57e-05 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 46.84 E-value: 1.57e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 62 QHLGFSDAVFGFGAGIFFLGYVIFEVPSNMLLVRVGPRRWITRIVVSWGIVSGLTALVSTPMQFYVMRFLLGVAEAGFIP 141
Cdd:cd06173 237 EVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNV 316
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 504814691 142 AIVLYMARSFPGRRRARILSMFYAALALAGLIGSPLTGFILQYFdgamqipGWKWIFILEALPAFLAALYVWK 214
Cdd:cd06173 317 PLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADAL-------GLSAVFLLAGALLLLAALLLLL 382
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
77-404 |
2.25e-05 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 46.55 E-value: 2.25e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 77 IFFLGYVIFEVPSNMLLVRVGPRRWITRIVVSWGIVSGLTALVSTPMQFYVMRFLLGVAEAGFIPAIVLYMARSFPGRRR 156
Cdd:TIGR00898 135 CFFVGVLLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGIGGIWVQAVVLNTEFLPKKQR 214
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 157 ARILSMFYAALALaGLIGSPLtgfiLQYFdgamqIPGWKWIFILEALPAFLAALYVWKgldddVTRSERF----SHADRA 232
Cdd:TIGR00898 215 AIVGTLIQVFFSL-GLVLLPL----VAYF-----IPDWRWLQLAVSLPTFLFFLLSWF-----VPESPRWlisqGRIEEA 279
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 233 --ILARV--------------LAEDRATAEPVNHRGLFSNWLVWAFCAIYFLDVFAIYGYTFWAPTMIKQMGI--GSDFV 294
Cdd:TIGR00898 280 lkILQRIakingkklpaevlsLSLEKDLSSSKKQYSFLDLFRTPNLRKTTLCLMMLWFTTAFSYYGLVLDLGNlgGNIYL 359
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 295 IGLLAALPNAVAVVVMVLfgrsADRRGGRRLHVAT-LLLMGATGLGLSVVWHDQLWLGMFALCIANAGL-ISFPPLFwsM 372
Cdd:TIGR00898 360 DLFISGLVELPAKLITLL----LIDRLGRRYTMAAsLLLAGVALLLLLFVPVDLYFLRTALAVLGKFGItSAFQMVY--L 433
|
330 340 350
....*....|....*....|....*....|...
gi 504814691 373 PTAAL-GTASVSMGIAVISSVGNLGGFFGPYAV 404
Cdd:TIGR00898 434 YTAELyPTVVRNLGVGVCSTMARVGSIISPFLV 466
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
60-210 |
3.33e-05 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 45.63 E-value: 3.33e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 60 MSQHLGFSDAVFGFGAGIFFLGYVIFEVPSNMLLVRVGPRRWITRIVVSWGIVSGLTAL--VSTPMQFYVMRFLLGVAEA 137
Cdd:COG2271 207 LVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALALLLLalLPSPALAIALLFLAGFGLG 286
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 504814691 138 GFIPAIVLYMARSFPGRRRARILSMFYAALALAGLIGSPLTGFILQYFdgamqipGWKWIFILEALPAFLAAL 210
Cdd:COG2271 287 GAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDAT-------GYQAAFLLLAALALLAAL 352
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
127-407 |
4.82e-05 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 45.21 E-value: 4.82e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 127 VMRFLLGVAEAGFIPAIVLYMARSFPGRRRARiLSMFYAALALAGLIGSPLTGFILQYFDGAMQIPGWKW-IFILEALPA 205
Cdd:cd17369 110 LLRLLQGLALGGEWGGAVLMAVEHAPPKRRGF-YGSFPQLGAPVGLLLATGVFLLLSALLSDEAFLSWGWrIPFLLSAVL 188
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 206 FLAALYVwkgldddvtrseRFSHADRAILARVLAEDRATAEPVNHRGLFSNWLVWAFCAIYFLDVFAIYGYTFWAPT-MI 284
Cdd:cd17369 189 VAVGLYI------------RLRLEETPVFRRAKEAGQVVRAPLVEVLRRHWRALLLAIGLRLAENVLFYLFTTFALSyAT 256
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 285 KQMGIG-SDFVIGLLAAlpNAVAVVVMVLFGRSADRRGGRRLHVATLLLMGATGLG--LSVVWHDQLWLGMFALCIANAG 361
Cdd:cd17369 257 QTLGVDrSTVLLAVLIA--SVVAAITIPLFGWLSDRVGRRPVYLAGALLAALFAFPffWLLDTGSTWLIVLAAVVVLGVL 334
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 504814691 362 lisfpplfWSMPTAALGTASVSM--------GIAVISSVGN-LGGFFGPYAVGYL 407
Cdd:cd17369 335 --------HGMMYGPQAAFLAELfptrvrytGASLGYQLGAiLGGGFAPLIATAL 381
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
257-412 |
5.09e-05 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 45.26 E-value: 5.09e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 257 WLVWAFCAIYFLDVFAIYGYTFWAPTMIKQMGIgSDFVIGLLAALPNAVAVVVMVLFGRSADRRGGRRLHVATLLLMGAT 336
Cdd:COG2223 5 RVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGL-SAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 337 GLGLSVVWHDQLWLGMFALCIANAGlISFPPlfwSMPTAA-------LGTAsvsMGIAVisSVGNLGGFFGPYAVGYLKQ 409
Cdd:COG2223 84 LLLLALAVSYWLLLLLGLLLGIGGG-GSFAV---GIALVSkwfppdrRGLA---LGLAA--GGGNLGAAVAAFLAPLLIA 154
|
...
gi 504814691 410 LSG 412
Cdd:COG2223 155 AFG 157
|
|
| MFS_SLC17A5 |
cd17381 |
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of ... |
76-213 |
5.89e-05 |
|
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of transporters; Solute carrier family 17 member 5 (SLC17A5) is also called sialin, H(+)/nitrate cotransporter, H(+)/sialic acid cotransporter (AST), membrane glycoprotein HP59, or vesicular H(+)/aspartate-glutamate cotransporter. It transports glucuronic acid and free sialic acid out of the lysosome after its cleavage from sialoglycoconjugates, which is required for normal CNS myelination. It also mediates the membrane potential-dependent uptake of aspartate and glutamate into synaptic vesicles and synaptic-like microvesicles. In the plasma membrane, it functions as a nitrate transporter. Recessive mutations in the SLC17A5 gene cause the allelic disorders, Infantile sialic acid storage disease (ISSD) and Salla disease (a predominantly neurological disorder). SLC17A5 belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340939 [Multi-domain] Cd Length: 397 Bit Score: 45.16 E-value: 5.89e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 76 GIFFLGYVIFEVPSNMLLVRVGPRRWITRIVVSWGIVSGLTALVSTPMQFY--VMRFLLGVAEAGFIPAIVLYMARSFPG 153
Cdd:cd17381 72 GSFFYGYIITQIPGGYLASKIGGKLLLGFGILGTAVFTLLTPLAADLGAGYliAVRALEGLGEGVTFPAMHAMWASWAPP 151
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 504814691 154 RRRARILSMFYAALALAGLIGSPLTGFILQYFDgamqipgWKWIF-ILEALPAFLAALYVW 213
Cdd:cd17381 152 LERSRLLTISYAGAQLGTVVSLPLSGLICYYLD-------WTYVFyIFGAVGLLWFFLWIW 205
|
|
| MFS_GLUT_Class1_2_like |
cd17357 |
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ... |
68-419 |
6.22e-05 |
|
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340915 [Multi-domain] Cd Length: 447 Bit Score: 44.94 E-value: 6.22e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 68 DAVFGFGAGIFFLGYVIFEVPSNMLLVRVGpRRWITRIVVSWGIVSGLTALVSTPMQFYVM----RFLLGVAEAGFIPAI 143
Cdd:cd17357 48 DLLWSLIVSIFFIGGAIGSFISAFLANRFG-RKNGLLISNALLVVSSLLMFLSKSAKSPELlifgRFLVGIACGLSTGFV 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 144 VLYMARSFPGRRRARILSMFYAALALAGLIGSpltGFILQYFDGAMQipGWKWIFILEALPA--FLAA----------LY 211
Cdd:cd17357 127 PMYLQEISPSELRGALGSLTQIGVTLGILLGQ---VFGLPSVLGTET--LWPYLLFFPGIPAllQLAAlpffpespkfLL 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 212 VWKGLDDDVTRSERFSHADRAILARVLAEDRATAEPVNHRGLFSNWLVWA----------FCAIYFLDVFA-IYGYTFWA 280
Cdd:cd17357 202 ISKGDEEEAEKSLKFLRGIEDDVDQELEEIKKESEQMGDQKQVSLMQLLRdpslrlplllVLVVSASQQFSgINAIFFYS 281
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 281 PTMIKQMGIGSDFVIgLLAALPNAVAVVVMVLFGRSADRRGGRRLHVATLLLMGATGLGLSVV------WHDQLWLGMFA 354
Cdd:cd17357 282 TFIFENAGFSPQLAE-WANLGIGIVNVLSTIVGPFLIEKVGRRPLLLISLSVCAVALLLMSVFlflseqNSWMSYGCIVA 360
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 504814691 355 LCIANAGL-ISFPPLFWSMPTAALGTASVSMGIAVISSVGNLGGFFGPYAVGYLKQLSGNLAAPLF 419
Cdd:cd17357 361 IFLFIFFFaIGLGPIPWFIGAELFPQAPRSAAQSLGSSVNWTSNFIVGMAFPPLQSIGGGFVFIIF 426
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
75-213 |
6.44e-05 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 44.89 E-value: 6.44e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 75 AGIFFLGYVIFevpsnMLLVRVGPRRWITRIVVSWGIVSGLTALVS---------TPMQFYVMRFLLGVAEAGFIPAIVL 145
Cdd:cd17489 229 AGLFFTVYAIA-----LLLSRPFSGKLSDRKGPKTVIIPGLLLLALgllllsfagSPWMLLLAAVLYGLGFGLLFPALQA 303
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 504814691 146 YMARSFPGRRRARILSMFYAALALAGLIGSPLTGFILQYFdgamqipGWKWIFILEALPAFLAALYVW 213
Cdd:cd17489 304 LAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELF-------GYRAMFLLAAVVVLLALVLYI 364
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
34-385 |
7.32e-05 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 44.93 E-value: 7.32e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 34 QILPILMFAYVTSYIDRVNVSFAKLQMSQHLGFSDAVFGFGAGIFFLGYVIFEVPSNMLLVRVGPRRWITRIVVSWGIVS 113
Cdd:cd17345 3 QVFLGIFIGYAGYYLVRNNFSLAQPYLIEQYGLSKTEIGLIGSALSIAYGLSKFVMGNLSDRSNPKRFLAIGLILSAIIN 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 114 GLTALVSTPMQ----FYVMRFLLGVAEAGFIPAIVLYMARSFPGRRRARILSMFYAALALAGLIGSPLTGFILQYFDGAm 189
Cdd:cd17345 83 ILIGFVPSATSsvglMFILLFLNGWFQGMGWPPSGRTMVHWFSKKERGTWTSIWNISHNVGGGLVGPLAGLGLAIFGDG- 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 190 qipGWKWIFILEALPAFLAALYVWKGLDD----------DVTRSERFSHADRAIlarvlAEDRATAEPVNHRGLFSNWLV 259
Cdd:cd17345 162 ---WWRGAFIFPAIIAIIVAVIVLFLGKDtpeseglppiEEYKGDYPEEADGEE-----EEQELSAWEIFVKYVLKNKLL 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 260 WAFCAIYFLDVFAIYGYTFWAPTMIKQMGIGSDFVIGLLAALPNAVAVVVMVLFGRSADRRGGRRLHVATLLLMGATGLG 339
Cdd:cd17345 234 WYIAIANVFVYLVRYGILDWAPTYLSEVKGFSKAQAMWAFSLFEWAAIPGTLLAGWLSDKLFKGRRAPTGIIFMILVIVA 313
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 504814691 340 LSVVWH-DQLWLGMFALCIANAgLISFPPLFWSM------PTAALGTASVSMG 385
Cdd:cd17345 314 LIVYWLaPNVLVDLIALIALGF-LIYGPVMLIGLqalelvPKKAAGTAAGLTG 365
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
156-372 |
1.01e-04 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 44.52 E-value: 1.01e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 156 RARILSMFYAALALAGLIGSPLTGFILQYFDGAMQIPGWKWIFILEALPAFLAALYVWKGL--DDDVTRSERFSHADRAI 233
Cdd:cd17332 134 RTSLTSWRMFFATIGGLLVTVLPPPLVAYFGGGNASRGYFLTALIIGIIGIILLLICFFGTreRVVPPEEEKSKLPLLKS 213
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 234 LARVLAEDrataepvnhrglfsNWLVWAFCAIYFLDVFAIYG--YTFWAptmikQMGIGSDFVIGLLAALPNAVAVVVMV 311
Cdd:cd17332 214 LKALLKNR--------------PFLILLLAYLLYFLAFNIVNtvLVYYF-----KYVLGGRAELVLLLLLILSGALLALL 274
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 504814691 312 LFGRSADRRGGRRLHVATLLLMGATGLGLSVVWHDQLWLGMFALCIANAGLISFPPLFWSM 372
Cdd:cd17332 275 PWPPLKKRFGKKKAFFIGLLLAILGLLLLFFLPPGNLVLILVLAVLAGIGYGGANLLPWAM 335
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
262-412 |
1.10e-04 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 44.10 E-value: 1.10e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 262 FCAIYFLDVFAIYGYTFWAPTMIKQMGiGSDFVIGLLAALPNAVAVVVMVLFGRSADRRGGRRLHVATLLLMGATGLGLS 341
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYAESLG-ASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFA 79
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 504814691 342 VVwhDQLWLGMFALCIANAGLISFPPLFWSMPTAALGTASVSMGIAVISSVGNLGGFFGPYAVGYLKQLSG 412
Cdd:cd17325 80 FA--TSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALG 148
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
62-213 |
1.16e-04 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 44.07 E-value: 1.16e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 62 QHLGFSDAVFGFGAGIFFLGYVIFEVPSNMLLVRVGPRRWITRIVVSWGIVSGLTALVSTPMQFYVMRFLLGV---AEAG 138
Cdd:cd17370 227 QELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLymgAQES 306
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 504814691 139 FIPAIVlymARSFPGRRRARILSMFYAALALAGLIGSPLTGFILQYFdgamqipGWKWIFILEALPAFLAALYVW 213
Cdd:cd17370 307 IERAAV---ADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLI-------SPSAAFLFSAVLALIALLLLL 371
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
65-421 |
1.36e-04 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 43.70 E-value: 1.36e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 65 GFSDAVFGFGAGIFFLGYVIFEVPSNMLLVRVGPRRWITRIVVSWGIVSGLTALVSTPMQFYVMRFLLGVAEAGFIPAIV 144
Cdd:cd17477 27 GVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFVMGIGLAGLFVVSE 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 145 LYMARSFPGRRRARILSMFYAALALAGLIGspltGFILQYFDGAMQIPgwkwiFILEALPAFLAALYVWkgldddvtrse 224
Cdd:cd17477 107 SWLNALATNENRGRVLGLYSTVLGLGFALG----PLLLALVGTAGALP-----FLIAAVLLLLALVPLL----------- 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 225 rfshadraiLARVLAEDRATAEPVNHRGLFS-NWLVWAFCAIYFLDVFAIYGYtfwAPTMIKQMGIgSDFVIGLLAALPN 303
Cdd:cd17477 167 ---------LTRRAAPEIEEAESISLRRLLRiAPLALLGAFVAGFLEGAFYSL---LPLYGLRLGL-SVAQAALLLAAFV 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 304 AVAVVVMVLFGRSADRRGGRRLHVATLLLMGATGLGLSVVWHDQLWLgMFALCIANAGLISFPPLFWSM-----PTAALG 378
Cdd:cd17477 234 LGGLLLQWPLGWLADRFDRRRVLLGCALLGALAALLLPLVPGLPLAL-LVLLFLWGGAAGPLYTLALALagdrlPGDELV 312
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 504814691 379 TASVSMGIAVissvgNLGGFFGPYAVGYLKQLSGNLAAPLFLM 421
Cdd:cd17477 313 AANAALLLLY-----GLGSVIGPLLAGALMDAFGPHGLFLFLA 350
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
109-213 |
1.38e-04 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 43.79 E-value: 1.38e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 109 WGIVSGLTALVSTPMQFYVMRFLLGVAEAGFIPAIVLYMARSFPGRRRARILSMFYAALA-LAGLIGSPLTGFILQYfdg 187
Cdd:cd17476 73 FAIWSLIAGFSPNFIFFIICRALQGLGPAFLLPNAMALLGRTYPPGPRKNIVFSLFGATApLGFALGGVFGGLFAQL--- 149
|
90 100
....*....|....*....|....*..
gi 504814691 188 amqiPGWKWIF-ILEALPAFLAALYVW 213
Cdd:cd17476 150 ----AWWPWIFwFLAILAAIVAVAAIF 172
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
64-420 |
1.43e-04 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 43.72 E-value: 1.43e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 64 LGFSDAVFGFGAGIFFLGYVIFEVPSNMLLVRVGPRRWITRIVVSWGIVSGLTALVSTPMQFYVMRFLLGVAeAGFIPAI 143
Cdd:cd17330 29 LGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLARFLDGLT-GGNVSVA 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 144 VLYMARSFPGRRRARILSMFYAALALAGLIGSPLTGFILQYFdgamqipGWKWIFILEALPAFLAALYVWKGLdddvtrs 223
Cdd:cd17330 108 QAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPY-------GYALPFLVAAALALLNLVLVLFFL------- 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 224 erfshadrailarvlaedrataepvnhrglfsnWLVWAFCAIYFLDVFAIYGYT-FWAPTMIKQMGIGSDFVIGLLAALP 302
Cdd:cd17330 174 ---------------------------------PPLRRLLLVYFLIALAFAGLEsVFSLFLKDRFGFSPSQIGLLLALVG 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 303 NAVAVVVMVLFGRSADRRGGRRLHVATLLLMGATGLGLSVVWhdQLWLGMFALCIANAGLISFPPLFWSMPTAALGTASV 382
Cdd:cd17330 221 IAGILAQLLLIPRLAKRLGERKLLRLGLLLAIIGLLLLPFAS--SVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQ 298
|
330 340 350
....*....|....*....|....*....|....*...
gi 504814691 383 SMGIAVISSVGNLGGFFGPYAVGYLKQLSGNLAAPLFL 420
Cdd:cd17330 299 GKAQGIIQSLQSLARIIGPLLAGPLYSFLGPGVPFLLA 336
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
60-368 |
2.18e-04 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 43.31 E-value: 2.18e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 60 MSQHLGFSDAVFGFGAGIFFLGYVIFEVPSNMLLVRVGPRRWITRIVVSWGIVSGLTALVSTPMQFYVMRFLLGVAEAGF 139
Cdd:cd17478 22 LIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGIGSAAF 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 140 IPAiVLYMARSFPGRRRARILSMFYAALALAGLIGSPLTGFILQYFDGamqiPGWKWIFIlealPAFLAALYVWKGLDDD 219
Cdd:cd17478 102 HPE-GARLASQAAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGG----LGLLILLI----IPGLAVALLLLRLRPL 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 220 vtrserfshadrailaRVLAEDRATAEPVNHRGLFSNWLVWAF-CAIYFLDVFAIYGYTFWAPTMIKQMGiGSDFVIGLL 298
Cdd:cd17478 173 ----------------KKPEAKKAAAKSSARSTLKGVWRALLLlLIIVFLRSWVLSSLTTFLPFYLVQRG-YSLVFAGLL 235
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 299 AALPNAVAVVVMVLFGRSADRRGGRRLHVATLLLMGATGLGLsvvWHDQLWLGMFALCIANAGLISFPPL 368
Cdd:cd17478 236 LSLFLFAGAIGTLIGGPLSDRFGRRRVIIASLLLAAPFLLLF---LLTPGIWSYILLVLAGFLLFASFPV 302
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
77-213 |
2.47e-04 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 42.95 E-value: 2.47e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 77 IFFLGYVIFEVPSNMLLVRVGPRRWITRIVVSWGIVSGLTALVSTPMQFYVMRFLLGVAEAGFIPAIVLYMARSFPGRRR 156
Cdd:cd17317 33 IFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVGFVLGMEIVGPKYR 112
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 504814691 157 ARILSMFYAALALaGLIGSPLTGFIlqyfdgamqIPGWKWIFILEALPAFLAALYVW 213
Cdd:cd17317 113 SFVGILFGLFWAL-GYMLLALLAYL---------IRDWRWLQLAISLPGLLFLLLLW 159
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
8-213 |
3.05e-04 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 42.95 E-value: 3.05e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 8 NPGDLAAPTSAHDLAQEDRIFRRLAVQILPILMFAYVTSYIdrVNVSFAKLQMSQHLGFSDAVFGFGAGIFFLGYVIFEV 87
Cdd:COG2223 182 DPPAGAAAAAKASLRDQLEALRDPRFWLLSLLYFGTFGSFI--GFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRP 259
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 88 PSNMLLVRVGPRRWITRIVVSWGIVSGLTALVSTPMQFYVMRFLLGVAEAGFIPAIVL-YMARSFPGRRRARILSMFYAA 166
Cdd:COG2223 260 LGGWLSDRIGGRRVLLIVFALMALGLLLLALALGSLWLFLVLFLLLGLALGGGNGAVFaLVPDIFPTKNAGAVYGLVGAA 339
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 504814691 167 LALAGLIGSPLTGFILQYFDgamqipGWKWIFILEALPAFLAALYVW 213
Cdd:COG2223 340 GGLGGFLGPLLFGALLDATG------SYTAAFLVFAVLALVALVLTL 380
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
281-421 |
3.13e-04 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 42.54 E-value: 3.13e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 281 PTMIKQMGIgSDFVIGLLAALPNAVAVVVMVLFGRSADRRGGRRLHVATLLLmgaTGLGLSVV-WHDQLWLGMFALCIAN 359
Cdd:cd17478 20 PLLIAKLGL-SYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLL---TGLGLSLLgFAPNYWLLLLLVALAG 95
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 504814691 360 AGLISFPPLFWSMpTAALGTASVSMGIAVISSVGNLGGFFGPYAVGYLKQLSGNLAAPLFLM 421
Cdd:cd17478 96 IGSAAFHPEGARL-ASQAAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLI 156
|
|
| MFS_UhpC |
cd17488 |
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane ... |
33-193 |
4.79e-04 |
|
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane sensor protein UhpC acts as both a sensor and a transport protein. It is part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpC recognizes external glucose-6-phosphate (Glc6P) and induces transport by UhpT. It can also transport and sense Glc6P, and interacts with the histidine kinase UhpB, leading to the stimulation of the autokinase activity of UhpB. This group also includes the hexose phosphate transport protein UhpT from Chlamydia pneumoniae; it is a transport protein for sugar phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The UhpC group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341041 [Multi-domain] Cd Length: 364 Bit Score: 42.01 E-value: 4.79e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 33 VQILPILMFAYVTSYIDRVNVSFAKLQMSQHLGFSDAVFGFGAGIFFLGYVIFEVPSNMLLVRVGPRRWITRIVVSWGIV 112
Cdd:cd17488 2 IHILASMFIGYAVFYLTRKSFNAAMPAMLADLGLDKSDIGILGSLFYITYGVSKFVSGLMSDRSNPRYFMGIGLIATGII 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 113 SGLTALVSTPMQFYVMRFLLGVAEAGFIPAIVLYMARSFPGRRRARILSMFYAALALAGLIGSPLTGFILQYFD--GAMQ 190
Cdd:cd17488 82 NILFGFSSSLWAFAVLWTLNAFFQGWGWPPCARLLTHWYSRNERGFWWSIWNTSHNIGGALIPILTGFAALTYGwrAGMY 161
|
...
gi 504814691 191 IPG 193
Cdd:cd17488 162 VPG 164
|
|
| MFS_SLC45_SUC |
cd17313 |
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ... |
40-182 |
4.97e-04 |
|
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340871 [Multi-domain] Cd Length: 421 Bit Score: 42.23 E-value: 4.97e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 40 MFAYVTSYIDRvNVSFAKLQMSQHLGFSDAVFGFGAGIFFLGYVIFEVPSNMLLVRVGPRRWITRIVVSWGIVSGLTALV 119
Cdd:cd17313 253 FELFFTDYMGE-EVYHGTSAASSHYGAGVRMGAWGLLIFSLAFLIFSLPIGKLGKKIGRKKVYLIGLVLFAVGMALMALV 331
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 504814691 120 STPMQFYVMRFLLGVAEAGF--IPAIVLYMARSFPGRRRARILSMFYAALALAGLIGSPLTGFIL 182
Cdd:cd17313 332 HNVTVALVLFALGGIGWATIniNPYPLVSDYHSESGRGQGTDTGLLNLAISLAQILVSLLAGPII 396
|
|
| MFS_4 |
pfam06779 |
Uncharacterized MFS-type transporter YbfB; This family represents putative bacterial membrane ... |
59-420 |
5.51e-04 |
|
Uncharacterized MFS-type transporter YbfB; This family represents putative bacterial membrane proteins which may be sugar transporters. Members carry twelve transmembrane regions which are characteriztic of members of the major facilitator sugar-transporter superfamily.
Pssm-ID: 399632 [Multi-domain] Cd Length: 365 Bit Score: 41.97 E-value: 5.51e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 59 QMSQHLGFSDAVFGFGAGIFFLGYVIFEVPSNMLLVRVGPRRWITRIVVSWGIVSGLTALVSTPMQFYVM--RFLLGVAE 136
Cdd:pfam06779 18 VMIAEGQFSLSQAGLLAAANYAGYLAGALLASFAWRHGASRLRPALLAGLLATVLLLLAMAATSSFWAVLliRFLAGVAS 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 137 AGFIPAIVLYMARSFPGRRRARILSMFYAALALAGLIGSPLTGFILQYFDGAmqipgwKWIFILEALPAFLAALYVWKgl 216
Cdd:pfam06779 98 AAVMIFGSSLILGHATAARRAFVGALLFAGVGIGIALSGLLVPLGLQLGLGG------SSLWYGAGVLSAVLTLAVFP-- 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 217 dddVTRSERFSHAdrailarvlaedrATAEPVNhRGLFSNWLVWAFCAIYFLDVFAIYGYTFWAPTMIKQMGiGSDFVIG 296
Cdd:pfam06779 170 ---LLPRRAPRHA-------------SAPAPAA-KPLQRSLPLWILTLAYGLAGFGYIITATFLPAMARDGF-GGPAAAA 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 297 LLAALPNAVAVVVMVLFGRSADRRGGRRLHVATLLLMGAtGLGLSVVWHDQLWL-------GMFALCIANAGLISFPPLF 369
Cdd:pfam06779 232 LFWSLFGLAAALGVLVWLRAAKRWGTRPALTAALLIQAL-GVLLSLLSPSPAGLavssllfGGTFMAITSLVMQLARELA 310
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 504814691 370 WSMPTAALGTASVSMGIAVISsvgnlggffGPYAVGYLKQLSGNLAAPLFL 420
Cdd:pfam06779 311 PPAPRRLLGLMTASFGIGQIL---------GPLLASLLTAATGGLTPALLL 352
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
95-407 |
6.30e-04 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 41.79 E-value: 6.30e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 95 RVGPRRWITRIVVSWGIVSGLTALVSTPMQFYVMRFLLGVAEAGFIPAIVLyMARSFPGRRRARILSMFYAALALAGLIG 174
Cdd:cd17504 57 LYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAGRALQGIGGAVFPLAFAL-VREEFPPERVPVAQGILSATFGIGAGIG 135
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 175 SPLTGFILQYFdgamqipGWKWIFILEALPAFLAALYVwkgldddvtrserfshadrailarvlaedrataePVNHRGLF 254
Cdd:cd17504 136 LPLGGWIVQHL-------GWRWIFWTAAPVAVLLAALV----------------------------------PLIDLRLL 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 255 SNWLVWAFCAIYFLDVFAIYGYTFWAPTMIKQ----MGIGSDFVIGLLAALPNAVAVVVMVLFGRSADRRGGRRLHVATL 330
Cdd:cd17504 175 RRRNVLLANITALLAGFGMFMVFQLLPQLLQLptptGFGLGITEAGLLLLPGALVMLIAGPLAGRLIARVGPRRVLLIGL 254
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 504814691 331 LLMGAtGLGLSVVWHDQLWLGMFALCIANAGLISFPPLFWSMPTAALGTASVSMGIAVISSVGNLGGFFGPYAVGYL 407
Cdd:cd17504 255 VISAV-GLLLLALLHSSLWALVVALLLIGIGLGLAFASLPNIVVESVPPDRTGIATGMNTVLRTIGSAIGPAIAGAI 330
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
60-214 |
7.27e-04 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 41.40 E-value: 7.27e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 60 MSQHLGFSDAVFGFGAGIFFLGYVIFEVPSNMLLVRVGPRRWITRIV-----VSWGIVSGLTALVSTPMQFYVMRFLLGV 134
Cdd:cd17474 221 LPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLKKRFGARRIlviglLLYALSLLLLGFVPSLALLLIAIVLFGL 300
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 135 AEAGFIPAIVLYMARSFPGRRRARILSMFYAALALAGLIGSPLTGFILQYFdgamqipGWKWIFILEALPAFLAALYVWK 214
Cdd:cd17474 301 GLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIF-------GLSAPFLVGAAIALAAAVLLAL 373
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
77-419 |
8.14e-04 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 41.54 E-value: 8.14e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 77 IFFLGYVIFEVPSNMLLVRVGPRRWITRIVVSWGIVSGLTALVSTPMQFYVMRFLLGVAeAGFIPAIVLYMARSFPGRRR 156
Cdd:cd17333 39 SQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVVLMFLAGLG-AGILDTGANTFVGALFEESS 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 157 ARILSMFYAALALAGLIGSPLTGFILQyfdgamQIPGWKWIFILEALPAFLAALYVwkgldddvTRSERFSHADRAI-LA 235
Cdd:cd17333 118 ATRLNVLHGFFGLGALIGPLIATSLLT------SELSWSWAYLIIGLIYLLLAILI--------LLTLFPELPSARNpQQ 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 236 RVLAEDRATAEpvnhrgLFSNWLVWAFCAIYFLDVFAIYGYTFWAPTMIKQMGIGSDFVIGLLAALPNAVAVVVMVLFGR 315
Cdd:cd17333 184 SVGAFSASASR------LLRNPSIILGALALFLYVGAETAFSSWVPSYLVEKKHVSDGLAGYLLSGFWVGITIGRLLGGP 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 316 SADRRGGRRLHVATLLlmGATGLGLSVVWHDQLWLGMFALCIANAGLISFPPLFWSMPTAALGTASVSmGIAVISSVGNL 395
Cdd:cd17333 258 ISRRIKPHTLLVLSGS--GALLGLLILLLAPTLVVGLVATALLGLFMAALFPTILSLGISNLPYAKGK-GTSVLLAAGSI 334
|
330 340
....*....|....*....|....
gi 504814691 396 GGFFGPYAVGYLKQLSGNLAAPLF 419
Cdd:cd17333 335 GGAIIPFIMGFIAEAVGIQTAMLL 358
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
262-407 |
1.47e-03 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 40.48 E-value: 1.47e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 262 FCAIYFLDVFAIYGYTFWAPTMIKQMGIGSDFVIGLLAALPNAVAVVVMVLFGRSADRRGGRRLHVATLLLMGATGLGLs 341
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLL- 79
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 504814691 342 vVWHDQLWLGMFALCIANAGLISFPPLFWSMPTAALGTASVSMGIAVISSVGNLGGFFGPYAVGYL 407
Cdd:pfam07690 80 -LFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLL 144
|
|
| MFS_KgtP |
cd17367 |
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ... |
127-344 |
1.98e-03 |
|
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 40.36 E-value: 1.98e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 127 VMRFLLGVAEAGFIPAIVLYMARSFPGRRRARILSMFYAALALAGLIGSpLTGFILQYFDGAMQIPGWKW--IFILEALP 204
Cdd:cd17367 106 LARLLQGLSVGGEYGTSATYLSEVAPPGRRGFYSSFQYVTLIGGQLLAL-GVLLVLQHTLGEDQMAAWGWriPFLLGGVL 184
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 205 AfLAALYVWKGLDDdvtrSERFSHADRailarvlaedRATAEPVNHRGLFSNW----LVWAFCAIYFLdvfAIYGYTFWA 280
Cdd:cd17367 185 A-VVVLWLRRGLEE----TESFEAIAE----------SNEASAGTLRELRRHPrellLVVGLTAGGTL---AFYTWTTYL 246
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 504814691 281 PTMIKQMGIGSDFVIGLLAALPNAVAVVVMVLFGRSADRRGGRRlhvatlLLMGATGLGLSVVW 344
Cdd:cd17367 247 QKFLVNTAGFSKGDATWITTAALLVFMLLQPLGGRLSDRIGRRP------LLLFFGIGGTLATV 304
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
110-401 |
2.06e-03 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 40.33 E-value: 2.06e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 110 GIVSGLTALVSTPMQFYVMRFLLGVAeAGFIPAIVLYMARSFPGRRRARILSMFYAALALAGLIGSPLTGFILQYFdgam 189
Cdd:cd17391 77 AIVIGLMAFVTNVWQLLILRLLQGVF-SGYVPNATALIASQTPKEKSGWALGTLSTGVVAGTLIGPLLGGFLADLF---- 151
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 190 qipGWKWIFILEALPAFLAALYVWKGLDDDVTRSERFSHADRAILARVLAEDRATAepvnhrGLFSNWLVWAFCAIYFLD 269
Cdd:cd17391 152 ---GIRNVFFITGGLLFLAFLLTLFFVKEDFKPVEKKKMVSTKEVWNSVPNPSLLI------SLFVTTFIIQLANQSIEP 222
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 270 VFAIYgytfwaptmIKQMGIGSD---FVIGLLAALPNAVAVVVMVLFGRSADRRGGRRLHVATLLLMGATGLGLSVVWHD 346
Cdd:cd17391 223 ILTLY---------IRQLMGDASnlaFISGLVFSATGVSSLLSAPRLGKLGDRIGHHRILLGALLASALLYIPQAFVQTP 293
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 504814691 347 -QLWLGMFALCIANAGLIsfpPLFWSMPTAALGTASVSMGIAVISSVGNLGGFFGP 401
Cdd:cd17391 294 wQLGILRFLLGLATGGLL---PAINSLLAKITPKEVAGRIFGYNQSFQYLGNVAGP 346
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
39-207 |
2.21e-03 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 40.24 E-value: 2.21e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 39 LMFAYVTSYIdrvnvSFAKLQMSQHLGFSDAVFGFGAGIFFLGYVIFEVPSNMLLVRVGPRRWITRIVVSWGIVSGLTAL 118
Cdd:cd17359 11 LLFGYDTGVI-----NGALPFLQTDFNLTPFLEGLVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISALGSAF 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 119 VSTPMQFYVMRFLLGVAEAGFIPAIVLYMARSFPGRRRARILSMFYAALALaGLIGSPLTGFILQYFDGA--MQIPGWKW 196
Cdd:cd17359 86 SPNFTIFIIARIIGGLAVGGASALVPMYIAEVAPAEIRGRLVSLNQLMIVF-GQLLAYIVNYLIANAGGAdwLGAEGWRW 164
|
170
....*....|.
gi 504814691 197 IFILEALPAFL 207
Cdd:cd17359 165 MLGLEAIPAIL 175
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
12-212 |
2.87e-03 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 39.85 E-value: 2.87e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 12 LAAPTSAHDLAQEDRIFRRLAVQILPILMF-AYVTSYIDRVNVSFAKLQMSQHlGFSDAVFGFGAGIFFLGYVIFEVPSN 90
Cdd:cd17477 166 LLTRRAAPEIEEAESISLRRLLRIAPLALLgAFVAGFLEGAFYSLLPLYGLRL-GLSVAQAALLLAAFVLGGLLLQWPLG 244
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 91 MLLVRVGPRRWITRI-VVSWGIVSGLTALVSTPMQFYVMRFLLGVAEAGFIPAIVLYMARSFPGRRRARILSMFYAALAL 169
Cdd:cd17477 245 WLADRFDRRRVLLGCaLLGALAALLLPLVPGLPLALLVLLFLWGGAAGPLYTLALALAGDRLPGDELVAANAALLLLYGL 324
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 504814691 170 AGLIGSPLTGFILQYFDGamqipgwKWIFILEALPAFLAALYV 212
Cdd:cd17477 325 GSVIGPLLAGALMDAFGP-------HGLFLFLAAVALLFLLFL 360
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
72-421 |
2.88e-03 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 39.51 E-value: 2.88e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 72 GFGAGIFFLGYVIFEVPSNMLLVRVGPRRWITRIVVSWGIVSGLTALVSTPMQFYVMRFLLGvaeAGFIPAIVL-YMARS 150
Cdd:cd17472 35 GLALGIYGLTQAIFQIPFGLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQG---SGAISSVVMaLLADL 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 151 FPGRRRAR---ILSMFYAALALAGLIGSPLTGFILqyfdgamqipGWKWIFILEALPAFLAALYVWKGLDDDvTRSERFS 227
Cdd:cd17472 112 TREENRTKamaLIGASIGIAFAISMVLGPLLAAHL----------GVSGLFLITAILSLVSLLILLFFVPDP-PKIVQIS 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 228 HADRAILARVLAedrataepvnhrglfsNWLVWAFCAIYFLDVFAIYGYTFWAPTMIKQMGIGSDFVIGL-LAALpnAVA 306
Cdd:cd17472 181 EKEKKKLKKLLK----------------NKRLLRLDFSIFILHFVLMAFFYILPLLLTQLGGGKGQLWKVyLPAI--LIG 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 307 VVVMVLFGRSADRRG-GRRLHVATLLLMGATGLGLSVVWHDqLWLGMFALCIANAGLISFPPLFWSMPT--AALGTASVS 383
Cdd:cd17472 243 FILMVPFVIYAEKKGkMKQVFVSSILLIAVGFLLLLFAATS-LWLLIIGLIIFFIGFNLLEALLPSLVSkiAPKEYRGTA 321
|
330 340 350
....*....|....*....|....*....|....*...
gi 504814691 384 MGIavISSVGNLGGFFGPYAVGYLKQLSGNLAAPLFLM 421
Cdd:cd17472 322 MGI--YNTSQFLGSFLGGALGGLLWGLLGYSSVFLTIL 357
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
271-367 |
4.11e-03 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 39.14 E-value: 4.11e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 271 FAIYGYTFWAPTMIKQMGIgSDFVIGLLAALPNAVAVVVMVLFGRSADRRGGRRLHVATLLLMGATGLGLSVVwHDQLWL 350
Cdd:cd17475 10 LVAQGIPALAPFLQEDLHL-SLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALV-GSYPVL 87
|
90
....*....|....*..
gi 504814691 351 GMFaLCIANAGLISFPP 367
Cdd:cd17475 88 LVL-LFLVGAGYGSVQP 103
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
95-212 |
5.02e-03 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 38.70 E-value: 5.02e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 95 RVGPRRWITRIVVSWGIVSGLTALVSTPMQFYVMRFLLGVAEAGFIPAIVLYMARSFPGRRRARILSMFYAALALAGLIG 174
Cdd:cd17502 56 LFGRKWVLLIAIVIFELGSLLCGLAPNMTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPRERGKYQGYIGAVFGIASVAG 135
|
90 100 110
....*....|....*....|....*....|....*...
gi 504814691 175 SPLTGFILQYFdgamqipGWKWIFILEaLPAFLAALYV 212
Cdd:cd17502 136 PLIGGAFTDHL-------SWRWCFYIN-LPIGGLALAL 165
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|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
60-210 |
5.22e-03 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 38.74 E-value: 5.22e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 60 MSQHLGFSDAVFGFGAGIFFLGYVIFEVPSNMLLVRVGPRRWITRIVVSWGIVSGLTALVSTPMQFYVM--RFLLGVAEA 137
Cdd:cd17316 204 LQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLLSGSPTLLLllLFILSFFVG 283
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90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 504814691 138 GFIPAIVLYMARSFPGRRRARILSMFYAALALAGLIGSPLTGFILQYFDGAMqipGWKWIFILEALPAFLAAL 210
Cdd:cd17316 284 GVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTG---VPALILALLAIVALIVAL 353
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| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
28-186 |
5.86e-03 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 38.84 E-value: 5.86e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 28 FRRLAVQILPILMFAYVTSYIDRVNVSFAKLQMSQHLGFSDAvfGFGAGIFFLGYVIFEVPSNMLLVRVGPRRWItRIVV 107
Cdd:cd17333 196 LRNPSIILGALALFLYVGAETAFSSWVPSYLVEKKHVSDGLA--GYLLSGFWVGITIGRLLGGPISRRIKPHTLL-VLSG 272
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 108 SWGIVSGLTALVS-TPMQFYVMRFLLGVAEAGFIPAIVLYMARSFPgRRRARILSMFYAALALAGLIGSPLTGFILQYFD 186
Cdd:cd17333 273 SGALLGLLILLLApTLVVGLVATALLGLFMAALFPTILSLGISNLP-YAKGKGTSVLLAAGSIGGAIIPFIMGFIAEAVG 351
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| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
254-415 |
6.52e-03 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 38.75 E-value: 6.52e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 254 FSNWLVWAFCAIYFLDVFAIygytfwaptmikqmgigSDFVIGLLAALPNAVAVVVMVLFGRSADRRGGRRLHVATLLLM 333
Cdd:cd17329 13 LGFFMVWPFMAIYLHQQLGL-----------------SASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLR 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 334 GATGLGLsvVWHDQLWLGMFALCIANAGLISFPPLFWSMPTAALGTASVSMGIAVISSVGNLGGFFGPYAVGYLKQLSGN 413
Cdd:cd17329 76 ALGFALL--GFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYSFR 153
|
..
gi 504814691 414 LA 415
Cdd:cd17329 154 LL 155
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|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
170-355 |
9.64e-03 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 37.91 E-value: 9.64e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 170 AGLIGSPLTGFILQYFDGAmqipGWKWIFILEALPAFLAALyvwkgldddvtrserfshadraILARVLAEDRATAEPVN 249
Cdd:cd17370 135 LGAVLGPLLAALLLYLLGG----NYRTIFLLAAIPALLALL----------------------ILLFVVKEYPRPPKLRK 188
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504814691 250 HRGLFS----NWLVWAFCAIYFLDVFAIYGYTFWApTMIKQMGIgSDFVIGLLAALPNAVAVVVMVLFGRSADRRGGRRL 325
Cdd:cd17370 189 KSKKTSlkklPKAFWLYLLAVALFALGNFSFAFLI-LRAQELGL-SAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKL 266
|
170 180 190
....*....|....*....|....*....|
gi 504814691 326 HVATLLLMGATGLGLSVVWHDQLWLGMFAL 355
Cdd:cd17370 267 LILGYLSLALAYLGFALGSSLWLLLLGFIL 296
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