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Conserved domains on  [gi|504876031|ref|WP_015063133|]
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MULTISPECIES: nitric oxide reductase activation protein NorD [Enterobacteriaceae]

Protein Classification

vWA domain-containing protein( domain architecture ID 10106921)

vWA (von Willebrand factor type A) domain-containing protein may be involved in one of a wide variety of important cellular functions, including basal membrane formation, cell migration, cell differentiation, adhesion, haemostasis, signaling, chromosomal stability, malignant transformation and immune defenses

CATH:  3.40.50.410
PubMed:  10830113|12388743|12579041
SCOP:  3000832

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
vWA_norD_type cd01454
norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate ...
 499-658 6.96e-33

norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial denitrification has been established as NO3- ------> NO2- ------> NO -------> N2O ---------> N2. This reaction generally occurs under oxygen limiting conditions. Genetic and biochemical studies have shown that the first srep of the biochemical pathway is catalyzed by periplasmic nitrate reductases. This family is widely present in proteobacteria and firmicutes. This version of the domain is also present in some archaeal members. The function of the vWA domain in this sub-group is not known. Members of this subgroup have a conserved MIDAS motif.


:

Pssm-ID: 238731 [Multi-domain]  Cd Length: 174  Bit Score: 124.75  E-value: 6.96e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504876031 499 VGLVIVRDISGSMILDHRYIHAIKTDLALTLAIEANSKMHVANVIYPFVDKDFEV----IKTFDE----NAEETLSKFSL 570
Cdd:cd01454    1 LAVTLLLDLSGSMRSDRRIDVAKKAAVLLAEALEACGVPHAILGFTTDAGGRERVrwikIKDFDEslheRARKRLAALSP 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504876031 571 GCkgnNTPTGSALMAAVELLLESQFDRKIVFLITDGYPTESDYTISDVLTVAESN--GIEIAGVGIKTDELIGFDEGTFV 648
Cdd:cd01454   81 GG---NTRDGAAIRHAAERLLARPEKRKILLVISDGEPNDLDYYEGNVFATEDALraVIEARKLGIEVFGITIDRDATTV 157

                        170
                 ....*....|
gi 504876031 649 NVDDISLLPN 658
Cdd:cd01454  158 DKEYLKNIFG 167
MSCRAMM_ClfA super family cl41352
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 251-422 1.69e-09

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


The actual alignment was detected with superfamily member NF033609:

Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 61.08  E-value: 1.69e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504876031 251 DEAKEKQQEEDQNKDPQNDTDNSSGSENEPDSETNGDNQGEGDGDSE-EQDDDAGNGKAPMEDNEPSEQSKGDEESAESG 329
Cdd:NF033609 689 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDsDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS 768

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504876031 330 NGEPDGEPETDESANPDSYDADGTPSQIDSSNGNPSDGESNFSPEQWSILAKLLDDFLNSDEESEDFHEALANEISVIAA 409
Cdd:NF033609 769 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS 848

                        170
                 ....*....|...
gi 504876031 410 SVSDEVKAEFGAN 422
Cdd:NF033609 849 DSDSDSDSESDSN 861
 
Name Accession Description Interval E-value
vWA_norD_type cd01454
norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate ...
 499-658 6.96e-33

norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial denitrification has been established as NO3- ------> NO2- ------> NO -------> N2O ---------> N2. This reaction generally occurs under oxygen limiting conditions. Genetic and biochemical studies have shown that the first srep of the biochemical pathway is catalyzed by periplasmic nitrate reductases. This family is widely present in proteobacteria and firmicutes. This version of the domain is also present in some archaeal members. The function of the vWA domain in this sub-group is not known. Members of this subgroup have a conserved MIDAS motif.


Pssm-ID: 238731 [Multi-domain]  Cd Length: 174  Bit Score: 124.75  E-value: 6.96e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504876031 499 VGLVIVRDISGSMILDHRYIHAIKTDLALTLAIEANSKMHVANVIYPFVDKDFEV----IKTFDE----NAEETLSKFSL 570
Cdd:cd01454    1 LAVTLLLDLSGSMRSDRRIDVAKKAAVLLAEALEACGVPHAILGFTTDAGGRERVrwikIKDFDEslheRARKRLAALSP 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504876031 571 GCkgnNTPTGSALMAAVELLLESQFDRKIVFLITDGYPTESDYTISDVLTVAESN--GIEIAGVGIKTDELIGFDEGTFV 648
Cdd:cd01454   81 GG---NTRDGAAIRHAAERLLARPEKRKILLVISDGEPNDLDYYEGNVFATEDALraVIEARKLGIEVFGITIDRDATTV 157

                        170
                 ....*....|
gi 504876031 649 NVDDISLLPN 658
Cdd:cd01454  158 DKEYLKNIFG 167
ChlD COG1240
vWFA (von Willebrand factor type A) domain of Mg and Co chelatases [Coenzyme transport and ...
 501-663 2.60e-12

vWFA (von Willebrand factor type A) domain of Mg and Co chelatases [Coenzyme transport and metabolism];


Pssm-ID: 440853 [Multi-domain]  Cd Length: 262  Bit Score: 67.66  E-value: 2.60e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504876031 501 LVIVRDISGSMILDHRyIHAIKTDLA-LTLAIEANSKMHV------ANVIYPFvdkdfevikTFD-ENAEETLSKFSLGc 572
Cdd:COG1240   95 VVLVVDASGSMAAENR-LEAAKGALLdFLDDYRPRDRVGLvafggeAEVLLPL---------TRDrEALKRALDELPPG- 163

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504876031 573 kgNNTPTGSALMAAVELLL-ESQFDRKIVFLITDGYPTESDYTISDVLTVAESNGIEIAGVGIKTDELigfDE------- 644
Cdd:COG1240  164 --GGTPLGDALALALELLKrADPARRKVIVLLTDGRDNAGRIDPLEAAELAAAAGIRIYTIGVGTEAV---DEgllreia 238

                        170       180
                 ....*....|....*....|...
gi 504876031 645 ----GTFVNVDDISLLPNVVSKL 663
Cdd:COG1240  239 eatgGRYFRADDLSELAAIYREI 261
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 251-422 1.69e-09

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 61.08  E-value: 1.69e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504876031 251 DEAKEKQQEEDQNKDPQNDTDNSSGSENEPDSETNGDNQGEGDGDSE-EQDDDAGNGKAPMEDNEPSEQSKGDEESAESG 329
Cdd:NF033609 689 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDsDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS 768

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504876031 330 NGEPDGEPETDESANPDSYDADGTPSQIDSSNGNPSDGESNFSPEQWSILAKLLDDFLNSDEESEDFHEALANEISVIAA 409
Cdd:NF033609 769 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS 848

                        170
                 ....*....|...
gi 504876031 410 SVSDEVKAEFGAN 422
Cdd:NF033609 849 DSDSDSDSESDSN 861
VWA smart00327
von Willebrand factor (vWF) type A domain; VWA domains in extracellular eukaryotic proteins ...
 501-637 1.88e-09

von Willebrand factor (vWF) type A domain; VWA domains in extracellular eukaryotic proteins mediate adhesion via metal ion-dependent adhesion sites (MIDAS). Intracellular VWA domains and homologues in prokaryotes have recently been identified. The proposed VWA domains in integrin beta subunits have recently been substantiated using sequence-based methods.


Pssm-ID: 214621 [Multi-domain]  Cd Length: 175  Bit Score: 57.46  E-value: 1.88e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504876031   501 LVIVRDISGSMilDHRYIHAIKT---DLALTLAIeANSKMHVANVIY---PFVDKDFEVIKTFDEnAEETLSKFSLGCKG 574
Cdd:smart00327   2 VVFLLDGSGSM--GGNRFELAKEfvlKLVEQLDI-GPDGDRVGLVTFsddARVLFPLNDSRSKDA-LLEALASLSYKLGG 77

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 504876031   575 NnTPTGSALMAAVELLLESQ-----FDRKIVFLITDGYPTESDYTISDVLTVAESNGIEIAGVGIKTD 637
Cdd:smart00327  78 G-TNLGAALQYALENLFSKSagsrrGAPKVVILITDGESNDGPKDLLKAAKELKRSGVKVFVVGVGND 144
PHA03169 PHA03169
hypothetical protein; Provisional
 247-375 6.02e-09

hypothetical protein; Provisional


Pssm-ID: 223003 [Multi-domain]  Cd Length: 413  Bit Score: 58.44  E-value: 6.02e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504876031 247 ERLRDEAKEKQQEEDQNKDPQNDTDNS---SGSE--NEPDSETNGDNQGEGDGDSEEQDDD------AGNGKAPMEDNEP 315
Cdd:PHA03169  65 GHRQTESDTETAEESRHGEKEERGQGGpsgSGSEsvGSPTPSPSGSAEELASGLSPENTSGsspespASHSPPPSPPSHP 144

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 504876031 316 SEQSKGDEES-------AESGNGEPDGEPETDESANPDSYDADGTPSQIDS----SNGNPSDGESNFSPEQ 375
Cdd:PHA03169 145 GPHEPAPPEShnpspnqQPSSFLQPSHEDSPEEPEPPTSEPEPDSPGPPQSetptSSPPPQSPPDEPGEPQ 215
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 251-394 7.26e-09

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 59.15  E-value: 7.26e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504876031 251 DEAKEKQQEEDQNKDPQNDTDNSSGSENEPDSETNGDNQGEGDGDSE---EQDDDAGNGKAPMEDNEPSEQSKGDEESAE 327
Cdd:NF033609 719 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDsdsDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS 798

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 504876031 328 SGNGEPDGEPETDESANPDSYDADGTPSQIDSSNGNPSDGESNFSPEQWSILAKLLDDFLNSDEESE 394
Cdd:NF033609 799 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSESDSNSDSE 865
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 251-369 8.25e-09

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 58.77  E-value: 8.25e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504876031 251 DEAKEKQQEEDQNKDPQNDTDNSSGSENEPDSETNGDNQGEGDGDSeEQDDDAGNGKAPMEDNEPSEQSKGDEESAESGN 330
Cdd:NF033609 749 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS-DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 827

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 504876031 331 GEPDGEPETDESANPDSYDADGTPSQIDSSNGNPSDGES 369
Cdd:NF033609 828 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSESDSNSDSES 866
VWA pfam00092
von Willebrand factor type A domain;
574-662 8.83e-09

von Willebrand factor type A domain;


Pssm-ID: 459670 [Multi-domain]  Cd Length: 174  Bit Score: 55.36  E-value: 8.83e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504876031  574 GNNTPTGSALMAAVELLLESQF-----DRKIVFLITDGYPTESDytISDVLTVAESNGIEIAGVGIK---TDELIGF--- 642
Cdd:pfam00092  76 GGTTNTGKALKYALENLFSSAAgarpgAPKVVVLLTDGRSQDGD--PEEVARELKSAGVTVFAVGVGnadDEELRKIase 153

                          90       100
                  ....*....|....*....|.
gi 504876031  643 -DEGTFVNVDDISLLPNVVSK 662
Cdd:pfam00092 154 pGEGHVFTVSDFEALEDLQDQ 174
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 251-394 1.49e-08

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 58.00  E-value: 1.49e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504876031 251 DEAKEKQQEEDQNKDPQNDTDNSSGSENEPDSETNGDNQGEGDGDSE-EQDDDAGNGKAPMEDNEPSEQSKGDEESAESG 329
Cdd:NF033609 645 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDsDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS 724

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 504876031 330 NGEPDGEPETDESANPDSYDADGTPSQIDSSNGNPSDGESNFSPEQWSILAKLLDDFLNSDEESE 394
Cdd:NF033609 725 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 789
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 251-394 1.53e-08

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 58.00  E-value: 1.53e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504876031 251 DEAKEKQQEEDQNKDPQNDTDNSSGSENEPDSETNGDNQGEGDGDSE---EQDDDAGNGKAPMEDNEPSEQSKGDEESAE 327
Cdd:NF033609 659 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDsdsDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS 738

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 504876031 328 SGNGEPDGEPETDESANPDSYDADGTPSQIDSSNGNPSDGESNFSPEQWSILAKLLDDFLNSDEESE 394
Cdd:NF033609 739 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 805
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 251-394 2.69e-08

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 57.23  E-value: 2.69e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504876031 251 DEAKEKQQEEDQNKDPQNDTDNSSGSENEPDSETNGDNQGEGDGDSeEQDDDAGNGKAPMEDNEPSEQSKGDEESAESGN 330
Cdd:NF033609 673 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS-DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 751

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 504876031 331 GEPDGEPETDESANPDSYDADGTPSQIDSSNGNPSDGESNFSPEQWSILAKLLDDFLNSDEESE 394
Cdd:NF033609 752 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 815
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 260-394 1.53e-07

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 54.92  E-value: 1.53e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504876031 260 EDQNKDPQNDT-----DNSSGSENEPDSETNGDNQGEGDGDSEEQDDDAGNGKAPMEDNEPSEQ-SKGDEESAESGNGEP 333
Cdd:NF033609 559 EDSDSDPGSDSgsdssNSDSGSDSGSDSTSDSGSDSASDSDSASDSDSASDSDSASDSDSASDSdSASDSDSASDSDSAS 638

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 504876031 334 DGEPETDESANPDSYDADGTPSQIDSSNGNPSDGESNFSPEQWSILAKLLDDFLNSDEESE 394
Cdd:NF033609 639 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 699
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 261-394 1.61e-07

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 54.92  E-value: 1.61e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504876031 261 DQNKDPQNDTDNSSGSENEPDSETNGDNQGEGDGDSEEQDDDAGNgkapmEDNEPSEQSKGDEESAESGNGEPDGEPETD 340
Cdd:NF033609 577 DSGSDSGSDSTSDSGSDSASDSDSASDSDSASDSDSASDSDSASD-----SDSASDSDSASDSDSASDSDSDSDSDSDSD 651

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 504876031 341 ESANPDSYDADGTPSQIDSSNGNPSDGESNFSPEQWSILAKLLDDFLNSDEESE 394
Cdd:NF033609 652 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 705
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 251-394 2.71e-07

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 54.14  E-value: 2.71e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504876031 251 DEAKEKQQEEDQNKDPQNDTDNSSGSENEPDSETNGDNQGEGDGDSE-EQDDDAGNGKAPMEDNEPSEQSKGDEESAESG 329
Cdd:NF033609 585 DSTSDSGSDSASDSDSASDSDSASDSDSASDSDSASDSDSASDSDSAsDSDSASDSDSDSDSDSDSDSDSDSDSDSDSDS 664

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 504876031 330 NGEPDGEPETDESANPDSYDADGTPSQIDSSNGNPSDGESNFSPEQWSILAKLLDDFLNSDEESE 394
Cdd:NF033609 665 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 729
CobT2 COG4547
Cobalamin biosynthesis cobaltochelatase CobT subunit [Coenzyme transport and metabolism]; ...
 237-351 9.27e-07

Cobalamin biosynthesis cobaltochelatase CobT subunit [Coenzyme transport and metabolism]; Cobalamin biosynthesis cobaltochelatase CobT subunit is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 443611 [Multi-domain]  Cd Length: 608  Bit Score: 52.10  E-value: 9.27e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504876031 237 SLARKTLALLErLRDEAKEKQQEEDQnkDPQNDTDNSSGSENEPDSETNGDNQGEGDGDSEEQDDDAGNGKAPMEDNEPS 316
Cdd:COG4547  196 RAVRDLLRDLD-LAEELGEDEDEEDE--DDEDDSGEQEEDEEDGEDEDEESDEGAEAEDAEASGDDAEEGESEAAEAESD 272

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 504876031 317 EqskGDEESAESGNGEPDGEPETDESANPDSYDAD 351
Cdd:COG4547  273 E---MAEEAEGEDSEEPGEPWRPNAPPPDDPADPD 304
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 251-382 1.29e-06

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 51.83  E-value: 1.29e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504876031 251 DEAKEKQQEEDQNKDPQNDTDNSSGSENEPDSETNGDNQGEGDGDSE-EQDDDAGNGKAPMEDNEPSEQSKGDEESAESG 329
Cdd:NF033609 775 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDsDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS 854

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 504876031 330 NGEPDGEPETDESANPDSYDADGTPSQIDSSNGNP------------SDGESNFSpEQWSILAKL 382
Cdd:NF033609 855 DSESDSNSDSESGSNNNVVPPNSPKNGTNASNKNEakdskeplpdtgSEDEANTS-LIWGLLASL 918
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 259-394 1.07e-05

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 48.75  E-value: 1.07e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504876031 259 EEDQNKDPQNDTDNSSGSENEPDSETNGDNQGEGDGDSEE-QDDDAGNGKAPMEDNEPSEQSKGDEESAESGNGEPDGEP 337
Cdd:NF033609 581 DSGSDSTSDSGSDSASDSDSASDSDSASDSDSASDSDSASdSDSASDSDSASDSDSASDSDSDSDSDSDSDSDSDSDSDS 660

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 504876031 338 ETDESANPDSYDADGTPSQIDSSNGNPSDGESNFSPEQWSILAKLLDDFLNSDEESE 394
Cdd:NF033609 661 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 717
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 250-352 2.12e-05

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 48.07  E-value: 2.12e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504876031   250 RDEAKEKQQEEDQNKDPQNDTDNSSGSENEPDSETNGDNQGEGDGDSEEQDDDAGNGkapmEDNEPSEQSKGDEESAESG 329
Cdd:TIGR00927  641 TGERTGEEGERPTEAEGENGEESGGEAEQEGETETKGENESEGEIPAERKGEQEGEG----EIEAKEADHKGETEAEEVE 716

                           90       100
                   ....*....|....*....|...
gi 504876031   330 NGEpDGEPETDESANPDSYDADG 352
Cdd:TIGR00927  717 HEG-ETEAEGTEDEGEIETGEEG 738
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 256-394 1.30e-04

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 45.29  E-value: 1.30e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504876031 256 KQQEEDQNKDP-QNDTDNSSGSENEPD-------SETNGDNQGEGDGDSEEQDDDAGNGKAPMEDNEPSEQ-SKGDEESA 326
Cdd:NF033609 546 EQPDEPGEIEPiPEDSDSDPGSDSGSDssnsdsgSDSGSDSTSDSGSDSASDSDSASDSDSASDSDSASDSdSASDSDSA 625

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 504876031 327 ESGNGEPDGEPETDESANPDSYDADGTPSQIDSSNGNPSDGESNFSPEQWSILAKLLDDFLNSDEESE 394
Cdd:NF033609 626 SDSDSASDSDSASDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 693
 
Name Accession Description Interval E-value
vWA_norD_type cd01454
norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate ...
 499-658 6.96e-33

norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial denitrification has been established as NO3- ------> NO2- ------> NO -------> N2O ---------> N2. This reaction generally occurs under oxygen limiting conditions. Genetic and biochemical studies have shown that the first srep of the biochemical pathway is catalyzed by periplasmic nitrate reductases. This family is widely present in proteobacteria and firmicutes. This version of the domain is also present in some archaeal members. The function of the vWA domain in this sub-group is not known. Members of this subgroup have a conserved MIDAS motif.


Pssm-ID: 238731 [Multi-domain]  Cd Length: 174  Bit Score: 124.75  E-value: 6.96e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504876031 499 VGLVIVRDISGSMILDHRYIHAIKTDLALTLAIEANSKMHVANVIYPFVDKDFEV----IKTFDE----NAEETLSKFSL 570
Cdd:cd01454    1 LAVTLLLDLSGSMRSDRRIDVAKKAAVLLAEALEACGVPHAILGFTTDAGGRERVrwikIKDFDEslheRARKRLAALSP 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504876031 571 GCkgnNTPTGSALMAAVELLLESQFDRKIVFLITDGYPTESDYTISDVLTVAESN--GIEIAGVGIKTDELIGFDEGTFV 648
Cdd:cd01454   81 GG---NTRDGAAIRHAAERLLARPEKRKILLVISDGEPNDLDYYEGNVFATEDALraVIEARKLGIEVFGITIDRDATTV 157

                        170
                 ....*....|
gi 504876031 649 NVDDISLLPN 658
Cdd:cd01454  158 DKEYLKNIFG 167
ChlD COG1240
vWFA (von Willebrand factor type A) domain of Mg and Co chelatases [Coenzyme transport and ...
 501-663 2.60e-12

vWFA (von Willebrand factor type A) domain of Mg and Co chelatases [Coenzyme transport and metabolism];


Pssm-ID: 440853 [Multi-domain]  Cd Length: 262  Bit Score: 67.66  E-value: 2.60e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504876031 501 LVIVRDISGSMILDHRyIHAIKTDLA-LTLAIEANSKMHV------ANVIYPFvdkdfevikTFD-ENAEETLSKFSLGc 572
Cdd:COG1240   95 VVLVVDASGSMAAENR-LEAAKGALLdFLDDYRPRDRVGLvafggeAEVLLPL---------TRDrEALKRALDELPPG- 163

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504876031 573 kgNNTPTGSALMAAVELLL-ESQFDRKIVFLITDGYPTESDYTISDVLTVAESNGIEIAGVGIKTDELigfDE------- 644
Cdd:COG1240  164 --GGTPLGDALALALELLKrADPARRKVIVLLTDGRDNAGRIDPLEAAELAAAAGIRIYTIGVGTEAV---DEgllreia 238

                        170       180
                 ....*....|....*....|...
gi 504876031 645 ----GTFVNVDDISLLPNVVSKL 663
Cdd:COG1240  239 eatgGRYFRADDLSELAAIYREI 261
vWFA cd00198
Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation ...
 501-637 3.61e-10

Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of fold. The vWA domain, since its discovery, has drawn great interest because of its widespread occurrence and its involvement in a wide variety of important cellular functions. These include basal membrane formation, cell migration, cell differentiation, adhesion, haemostasis, signaling, chromosomal stability, malignant transformation and in immune defenses In integrins these domains form heterodimers while in vWF it forms multimers. There are different interaction surfaces of this domain as seen by the various molecules it complexes with. Ligand binding in most cases is mediated by the presence of a metal ion dependent adhesion site termed as the MIDAS motif that is a characteristic feature of most, if not all A domains.


Pssm-ID: 238119 [Multi-domain]  Cd Length: 161  Bit Score: 59.12  E-value: 3.61e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504876031 501 LVIVRDISGSMILD--HRYIHAIKTdlALTLAIEANSKMHVAnvIYPFVDKDFEVI----KTFDENAEETLSKFSLGCKG 574
Cdd:cd00198    3 IVFLLDVSGSMGGEklDKAKEALKA--LVSSLSASPPGDRVG--LVTFGSNARVVLplttDTDKADLLEAIDALKKGLGG 78

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 504876031 575 NnTPTGSALMAAVELLLESQFD--RKIVFLITDGYPTESDYTISDVLTVAESNGIEIAGVGIKTD 637
Cdd:cd00198   79 G-TNIGAALRLALELLKSAKRPnaRRVIILLTDGEPNDGPELLAEAARELRKLGITVYTIGIGDD 142
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 251-422 1.69e-09

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 61.08  E-value: 1.69e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504876031 251 DEAKEKQQEEDQNKDPQNDTDNSSGSENEPDSETNGDNQGEGDGDSE-EQDDDAGNGKAPMEDNEPSEQSKGDEESAESG 329
Cdd:NF033609 689 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDsDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS 768

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504876031 330 NGEPDGEPETDESANPDSYDADGTPSQIDSSNGNPSDGESNFSPEQWSILAKLLDDFLNSDEESEDFHEALANEISVIAA 409
Cdd:NF033609 769 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS 848

                        170
                 ....*....|...
gi 504876031 410 SVSDEVKAEFGAN 422
Cdd:NF033609 849 DSDSDSDSESDSN 861
VWA smart00327
von Willebrand factor (vWF) type A domain; VWA domains in extracellular eukaryotic proteins ...
 501-637 1.88e-09

von Willebrand factor (vWF) type A domain; VWA domains in extracellular eukaryotic proteins mediate adhesion via metal ion-dependent adhesion sites (MIDAS). Intracellular VWA domains and homologues in prokaryotes have recently been identified. The proposed VWA domains in integrin beta subunits have recently been substantiated using sequence-based methods.


Pssm-ID: 214621 [Multi-domain]  Cd Length: 175  Bit Score: 57.46  E-value: 1.88e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504876031   501 LVIVRDISGSMilDHRYIHAIKT---DLALTLAIeANSKMHVANVIY---PFVDKDFEVIKTFDEnAEETLSKFSLGCKG 574
Cdd:smart00327   2 VVFLLDGSGSM--GGNRFELAKEfvlKLVEQLDI-GPDGDRVGLVTFsddARVLFPLNDSRSKDA-LLEALASLSYKLGG 77

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 504876031   575 NnTPTGSALMAAVELLLESQ-----FDRKIVFLITDGYPTESDYTISDVLTVAESNGIEIAGVGIKTD 637
Cdd:smart00327  78 G-TNLGAALQYALENLFSKSagsrrGAPKVVILITDGESNDGPKDLLKAAKELKRSGVKVFVVGVGND 144
PHA03169 PHA03169
hypothetical protein; Provisional
 247-375 6.02e-09

hypothetical protein; Provisional


Pssm-ID: 223003 [Multi-domain]  Cd Length: 413  Bit Score: 58.44  E-value: 6.02e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504876031 247 ERLRDEAKEKQQEEDQNKDPQNDTDNS---SGSE--NEPDSETNGDNQGEGDGDSEEQDDD------AGNGKAPMEDNEP 315
Cdd:PHA03169  65 GHRQTESDTETAEESRHGEKEERGQGGpsgSGSEsvGSPTPSPSGSAEELASGLSPENTSGsspespASHSPPPSPPSHP 144

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 504876031 316 SEQSKGDEES-------AESGNGEPDGEPETDESANPDSYDADGTPSQIDS----SNGNPSDGESNFSPEQ 375
Cdd:PHA03169 145 GPHEPAPPEShnpspnqQPSSFLQPSHEDSPEEPEPPTSEPEPDSPGPPQSetptSSPPPQSPPDEPGEPQ 215
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 251-394 7.26e-09

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 59.15  E-value: 7.26e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504876031 251 DEAKEKQQEEDQNKDPQNDTDNSSGSENEPDSETNGDNQGEGDGDSE---EQDDDAGNGKAPMEDNEPSEQSKGDEESAE 327
Cdd:NF033609 719 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDsdsDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS 798

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 504876031 328 SGNGEPDGEPETDESANPDSYDADGTPSQIDSSNGNPSDGESNFSPEQWSILAKLLDDFLNSDEESE 394
Cdd:NF033609 799 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSESDSNSDSE 865
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 251-369 8.25e-09

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 58.77  E-value: 8.25e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504876031 251 DEAKEKQQEEDQNKDPQNDTDNSSGSENEPDSETNGDNQGEGDGDSeEQDDDAGNGKAPMEDNEPSEQSKGDEESAESGN 330
Cdd:NF033609 749 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS-DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 827

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 504876031 331 GEPDGEPETDESANPDSYDADGTPSQIDSSNGNPSDGES 369
Cdd:NF033609 828 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSESDSNSDSES 866
VWA pfam00092
von Willebrand factor type A domain;
574-662 8.83e-09

von Willebrand factor type A domain;


Pssm-ID: 459670 [Multi-domain]  Cd Length: 174  Bit Score: 55.36  E-value: 8.83e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504876031  574 GNNTPTGSALMAAVELLLESQF-----DRKIVFLITDGYPTESDytISDVLTVAESNGIEIAGVGIK---TDELIGF--- 642
Cdd:pfam00092  76 GGTTNTGKALKYALENLFSSAAgarpgAPKVVVLLTDGRSQDGD--PEEVARELKSAGVTVFAVGVGnadDEELRKIase 153

                          90       100
                  ....*....|....*....|.
gi 504876031  643 -DEGTFVNVDDISLLPNVVSK 662
Cdd:pfam00092 154 pGEGHVFTVSDFEALEDLQDQ 174
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 251-394 1.49e-08

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 58.00  E-value: 1.49e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504876031 251 DEAKEKQQEEDQNKDPQNDTDNSSGSENEPDSETNGDNQGEGDGDSE-EQDDDAGNGKAPMEDNEPSEQSKGDEESAESG 329
Cdd:NF033609 645 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDsDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS 724

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 504876031 330 NGEPDGEPETDESANPDSYDADGTPSQIDSSNGNPSDGESNFSPEQWSILAKLLDDFLNSDEESE 394
Cdd:NF033609 725 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 789
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 251-394 1.53e-08

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 58.00  E-value: 1.53e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504876031 251 DEAKEKQQEEDQNKDPQNDTDNSSGSENEPDSETNGDNQGEGDGDSE---EQDDDAGNGKAPMEDNEPSEQSKGDEESAE 327
Cdd:NF033609 659 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDsdsDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS 738

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 504876031 328 SGNGEPDGEPETDESANPDSYDADGTPSQIDSSNGNPSDGESNFSPEQWSILAKLLDDFLNSDEESE 394
Cdd:NF033609 739 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 805
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 251-394 2.69e-08

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 57.23  E-value: 2.69e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504876031 251 DEAKEKQQEEDQNKDPQNDTDNSSGSENEPDSETNGDNQGEGDGDSeEQDDDAGNGKAPMEDNEPSEQSKGDEESAESGN 330
Cdd:NF033609 673 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS-DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 751

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 504876031 331 GEPDGEPETDESANPDSYDADGTPSQIDSSNGNPSDGESNFSPEQWSILAKLLDDFLNSDEESE 394
Cdd:NF033609 752 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 815
PHA03169 PHA03169
hypothetical protein; Provisional
 251-355 1.51e-07

hypothetical protein; Provisional


Pssm-ID: 223003 [Multi-domain]  Cd Length: 413  Bit Score: 54.21  E-value: 1.51e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504876031 251 DEAKEKQQEEDQnkDPQNDTDNSSGSENEPDSETNGDNQGEGDGDSEEQDDDAGNGKAPmeDNEPSEQSKGDEESAESGN 330
Cdd:PHA03169 125 GSSPESPASHSP--PPSPPSHPGPHEPAPPESHNPSPNQQPSSFLQPSHEDSPEEPEPP--TSEPEPDSPGPPQSETPTS 200

                         90       100
                 ....*....|....*....|....*
gi 504876031 331 GEPDGEPeTDESANPDSYDADGTPS 355
Cdd:PHA03169 201 SPPPQSP-PDEPGEPQSPTPQQAPS 224
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 260-394 1.53e-07

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 54.92  E-value: 1.53e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504876031 260 EDQNKDPQNDT-----DNSSGSENEPDSETNGDNQGEGDGDSEEQDDDAGNGKAPMEDNEPSEQ-SKGDEESAESGNGEP 333
Cdd:NF033609 559 EDSDSDPGSDSgsdssNSDSGSDSGSDSTSDSGSDSASDSDSASDSDSASDSDSASDSDSASDSdSASDSDSASDSDSAS 638

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 504876031 334 DGEPETDESANPDSYDADGTPSQIDSSNGNPSDGESNFSPEQWSILAKLLDDFLNSDEESE 394
Cdd:NF033609 639 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 699
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 261-394 1.61e-07

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 54.92  E-value: 1.61e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504876031 261 DQNKDPQNDTDNSSGSENEPDSETNGDNQGEGDGDSEEQDDDAGNgkapmEDNEPSEQSKGDEESAESGNGEPDGEPETD 340
Cdd:NF033609 577 DSGSDSGSDSTSDSGSDSASDSDSASDSDSASDSDSASDSDSASD-----SDSASDSDSASDSDSASDSDSDSDSDSDSD 651

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 504876031 341 ESANPDSYDADGTPSQIDSSNGNPSDGESNFSPEQWSILAKLLDDFLNSDEESE 394
Cdd:NF033609 652 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 705
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 251-394 2.71e-07

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 54.14  E-value: 2.71e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504876031 251 DEAKEKQQEEDQNKDPQNDTDNSSGSENEPDSETNGDNQGEGDGDSE-EQDDDAGNGKAPMEDNEPSEQSKGDEESAESG 329
Cdd:NF033609 585 DSTSDSGSDSASDSDSASDSDSASDSDSASDSDSASDSDSASDSDSAsDSDSASDSDSDSDSDSDSDSDSDSDSDSDSDS 664

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 504876031 330 NGEPDGEPETDESANPDSYDADGTPSQIDSSNGNPSDGESNFSPEQWSILAKLLDDFLNSDEESE 394
Cdd:NF033609 665 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 729
PHA03169 PHA03169
hypothetical protein; Provisional
 250-375 4.55e-07

hypothetical protein; Provisional


Pssm-ID: 223003 [Multi-domain]  Cd Length: 413  Bit Score: 52.67  E-value: 4.55e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504876031 250 RDEAKEKQQEEDQNKDPQNDTDNSSG-----------SENEPDSETNGDNQgEGDGDSEEQDDDAGNGKAPMEDNEPSEQ 318
Cdd:PHA03169  30 REQAGRRRGTAARAAKPAPPAPTTSGpqvravaeqghRQTESDTETAEESR-HGEKEERGQGGPSGSGSESVGSPTPSPS 108

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 504876031 319 SKGDEESA-----ESGNGEPDGEPETDESANPDSYDADGTPSQIDSSNGNPSDGESNFSPEQ 375
Cdd:PHA03169 109 GSAEELASglspeNTSGSSPESPASHSPPPSPPSHPGPHEPAPPESHNPSPNQQPSSFLQPS 170
ViaA COG2425
Uncharacterized conserved protein, contains a von Willebrand factor type A (vWA) domain ...
 390-634 4.91e-07

Uncharacterized conserved protein, contains a von Willebrand factor type A (vWA) domain [Function unknown];


Pssm-ID: 441973 [Multi-domain]  Cd Length: 263  Bit Score: 51.60  E-value: 4.91e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504876031 390 DEESEDFHEALANEISVIAASVSDEVKAEFGANEWDLPDLLIDLNVYNEALNISQTLGADLSVLQQVKMRGQFKTRDRGL 469
Cdd:COG2425   11 LAALLLAPAPATALLLAGLLRAALALGLALALRAALLALLLLLLRAALALLTLLAGLVLLALDALLLAALLAALLDALLL 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504876031 470 SFDI-NRLIQSPMGVRDVFRSQSESKNRGHVGLVIvrDISGSMildhryiHAIKTDLALTLAIEANSKM--HVANVIYPF 546
Cdd:COG2425   91 AVLLlALLLLAALLLLAAPASAAVPLLEGPVVLCV--DTSGSM-------AGSKEAAAKAAALALLRALrpNRRFGVILF 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504876031 547 ---VDKDFEVikTFDENAEETLSKFSLGCKGNNTPTGSALMAAVELLLESQFDRKIVFLITDGYPTESDYTISDVLTVAE 623
Cdd:COG2425  162 dteVVEDLPL--TADDGLEDAIEFLSGLFAGGGTDIAPALRAALELLEEPDYRNADIVLITDGEAGVSPEELLREVRAKE 239

                        250
                 ....*....|.
gi 504876031 624 SnGIEIAGVGI 634
Cdd:COG2425  240 S-GVRLFTVAI 249
CobT2 COG4547
Cobalamin biosynthesis cobaltochelatase CobT subunit [Coenzyme transport and metabolism]; ...
 237-351 9.27e-07

Cobalamin biosynthesis cobaltochelatase CobT subunit [Coenzyme transport and metabolism]; Cobalamin biosynthesis cobaltochelatase CobT subunit is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 443611 [Multi-domain]  Cd Length: 608  Bit Score: 52.10  E-value: 9.27e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504876031 237 SLARKTLALLErLRDEAKEKQQEEDQnkDPQNDTDNSSGSENEPDSETNGDNQGEGDGDSEEQDDDAGNGKAPMEDNEPS 316
Cdd:COG4547  196 RAVRDLLRDLD-LAEELGEDEDEEDE--DDEDDSGEQEEDEEDGEDEDEESDEGAEAEDAEASGDDAEEGESEAAEAESD 272

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 504876031 317 EqskGDEESAESGNGEPDGEPETDESANPDSYDAD 351
Cdd:COG4547  273 E---MAEEAEGEDSEEPGEPWRPNAPPPDDPADPD 304
TerY COG4245
Uncharacterized conserved protein YegL, contains vWA domain of TerY type [Function unknown];
493-637 9.93e-07

Uncharacterized conserved protein YegL, contains vWA domain of TerY type [Function unknown];


Pssm-ID: 443387 [Multi-domain]  Cd Length: 196  Bit Score: 49.92  E-value: 9.93e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504876031 493 SKNRGHVGLVIvrDISGSMILDHryIHAIKTDLALTL-AIEANskmhvanviyPFVDKDFEV-IKTFDENAEE-----TL 565
Cdd:COG4245    2 PMRRLPVYLLL--DTSGSMSGEP--IEALNEGLQALIdELRQD----------PYALETVEVsVITFDGEAKVllpltDL 67

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504876031 566 SKFS---LGCKGNnTPTGSALMAAVELL---------LESQFDRKIVFLITDGYPTESDYT--ISDVLTVAESNGIEIAG 631
Cdd:COG4245   68 EDFQppdLSASGG-TPLGAALELLLDLIerrvqkytaEGKGDWRPVVFLITDGEPTDSDWEaaLQRLKDGEAAKKANIFA 146


                 ....*.
gi 504876031 632 VGIKTD 637
Cdd:COG4245  147 IGVGPD 152
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 251-382 1.29e-06

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 51.83  E-value: 1.29e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504876031 251 DEAKEKQQEEDQNKDPQNDTDNSSGSENEPDSETNGDNQGEGDGDSE-EQDDDAGNGKAPMEDNEPSEQSKGDEESAESG 329
Cdd:NF033609 775 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDsDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS 854

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 504876031 330 NGEPDGEPETDESANPDSYDADGTPSQIDSSNGNP------------SDGESNFSpEQWSILAKL 382
Cdd:NF033609 855 DSESDSNSDSESGSNNNVVPPNSPKNGTNASNKNEakdskeplpdtgSEDEANTS-LIWGLLASL 918
PHA03169 PHA03169
hypothetical protein; Provisional
 251-356 2.27e-06

hypothetical protein; Provisional


Pssm-ID: 223003 [Multi-domain]  Cd Length: 413  Bit Score: 50.35  E-value: 2.27e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504876031 251 DEAKEKQQEEDQNKDPQNDTDNSSGSENEPDSEtNGDNQGEGdGDSEEQDDDAGNGKAPMEDNEPSEQSKGDEEsAESGN 330
Cdd:PHA03169 140 PPSHPGPHEPAPPESHNPSPNQQPSSFLQPSHE-DSPEEPEP-PTSEPEPDSPGPPQSETPTSSPPPQSPPDEP-GEPQS 216

                         90       100
                 ....*....|....*....|....*.
gi 504876031 331 GEPDGEPETDESANPDSYDADGTPSQ 356
Cdd:PHA03169 217 PTPQQAPSPNTQQAVEHEDEPTEPER 242
CobT2 COG4547
Cobalamin biosynthesis cobaltochelatase CobT subunit [Coenzyme transport and metabolism]; ...
 239-372 8.04e-06

Cobalamin biosynthesis cobaltochelatase CobT subunit [Coenzyme transport and metabolism]; Cobalamin biosynthesis cobaltochelatase CobT subunit is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 443611 [Multi-domain]  Cd Length: 608  Bit Score: 49.02  E-value: 8.04e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504876031 239 ARKTLALLERLrDEAKEKQQEEDQNKDpqNDTDNSSGSENEPDsetngdnqgEGDGDSEEQDDDagngkAPMEDnepSEQ 318
Cdd:COG4547  195 ARAVRDLLRDL-DLAEELGEDEDEEDE--DDEDDSGEQEEDEE---------DGEDEDEESDEG-----AEAED---AEA 254

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 504876031 319 SKGDEESAESGNGEPDGEPETDESANPDSYDADGTPSQidssNGNPSDGESNFS 372
Cdd:COG4547  255 SGDDAEEGESEAAEAESDEMAEEAEGEDSEEPGEPWRP----NAPPPDDPADPD 304
PHA03169 PHA03169
hypothetical protein; Provisional
 252-342 9.48e-06

hypothetical protein; Provisional


Pssm-ID: 223003 [Multi-domain]  Cd Length: 413  Bit Score: 48.43  E-value: 9.48e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504876031 252 EAKEKQQEEDQNKDP--QNDTDNSSGSENEPDSETNGDNQGEGDGDSEEQDDDagngkaPMEDNEPSEQSKGDEESAESG 329
Cdd:PHA03169 166 FLQPSHEDSPEEPEPptSEPEPDSPGPPQSETPTSSPPPQSPPDEPGEPQSPT------PQQAPSPNTQQAVEHEDEPTE 239

                         90
                 ....*....|...
gi 504876031 330 NGEPDGEPETDES 342
Cdd:PHA03169 240 PEREGPPFPGHRS 252
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 259-394 1.07e-05

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 48.75  E-value: 1.07e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504876031 259 EEDQNKDPQNDTDNSSGSENEPDSETNGDNQGEGDGDSEE-QDDDAGNGKAPMEDNEPSEQSKGDEESAESGNGEPDGEP 337
Cdd:NF033609 581 DSGSDSTSDSGSDSASDSDSASDSDSASDSDSASDSDSASdSDSASDSDSASDSDSASDSDSDSDSDSDSDSDSDSDSDS 660

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 504876031 338 ETDESANPDSYDADGTPSQIDSSNGNPSDGESNFSPEQWSILAKLLDDFLNSDEESE 394
Cdd:NF033609 661 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 717
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 250-352 2.12e-05

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 48.07  E-value: 2.12e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504876031   250 RDEAKEKQQEEDQNKDPQNDTDNSSGSENEPDSETNGDNQGEGDGDSEEQDDDAGNGkapmEDNEPSEQSKGDEESAESG 329
Cdd:TIGR00927  641 TGERTGEEGERPTEAEGENGEESGGEAEQEGETETKGENESEGEIPAERKGEQEGEG----EIEAKEADHKGETEAEEVE 716

                           90       100
                   ....*....|....*....|...
gi 504876031   330 NGEpDGEPETDESANPDSYDADG 352
Cdd:TIGR00927  717 HEG-ETEAEGTEDEGEIETGEEG 738
PRK13108 PRK13108
prolipoprotein diacylglyceryl transferase; Reviewed
 247-362 1.03e-04

prolipoprotein diacylglyceryl transferase; Reviewed


Pssm-ID: 237284 [Multi-domain]  Cd Length: 460  Bit Score: 45.35  E-value: 1.03e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504876031 247 ERLRDEAKEKQQEEDQNKDPQNDTDN-----SSGSENEPDSETNGDNQGEGDGDSEEQDDDAGNGKAPME--DNEPSEQS 319
Cdd:PRK13108 331 EAVKAEVAEVTDEVAAESVVQVADRDgestpAVEETSEADIEREQPGDLAGQAPAAHQVDAEAASAAPEEpaALASEAHD 410

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 504876031 320 KGDEESAESGNGEPD-GEPETDESANP--DSYDADGTPSQIDSSNG 362
Cdd:PRK13108 411 ETEPEVPEKAAPIPDpAKPDELAVAGPgdDPAEPDGIRRQDDFSSR 456
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 256-394 1.30e-04

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 45.29  E-value: 1.30e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504876031 256 KQQEEDQNKDP-QNDTDNSSGSENEPD-------SETNGDNQGEGDGDSEEQDDDAGNGKAPMEDNEPSEQ-SKGDEESA 326
Cdd:NF033609 546 EQPDEPGEIEPiPEDSDSDPGSDSGSDssnsdsgSDSGSDSTSDSGSDSASDSDSASDSDSASDSDSASDSdSASDSDSA 625

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 504876031 327 ESGNGEPDGEPETDESANPDSYDADGTPSQIDSSNGNPSDGESNFSPEQWSILAKLLDDFLNSDEESE 394
Cdd:NF033609 626 SDSDSASDSDSASDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 693
vWFA_subfamily_ECM cd01450
Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation ...
 501-635 2.92e-04

Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of fold. The vWA domain, since its discovery, has drawn great interest because of its widespread occurrence and its involvement in a wide variety of important cellular functions. These include basal membrane formation, cell migration, cell differentiation, adhesion, haemostasis, signaling, chromosomal stability, malignant transformation and in immune defenses In integrins these domains form heterodimers while in vWF it forms multimers. There are different interaction surfaces of this domain as seen by the various molecules it complexes with. Ligand binding in most cases is mediated by the presence of a metal ion dependent adhesion site termed as the MIDAS motif that is a characteristic feature of most, if not all A domains


Pssm-ID: 238727 [Multi-domain]  Cd Length: 161  Bit Score: 41.89  E-value: 2.92e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504876031 501 LVIVRDISGSMILDHRYIhaIK---TDLALTLAIeANSKMHVANVIY---PFVDKDFEVIKTFDEnAEETLSKFSLGcKG 574
Cdd:cd01450    3 IVFLLDGSESVGPENFEK--VKdfiEKLVEKLDI-GPDKTRVGLVQYsddVRVEFSLNDYKSKDD-LLKAVKNLKYL-GG 77

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 504876031 575 NNTPTGSALMAAVELLLESQFDR----KIVFLITDGYPTEsDYTISDVLTVAESNGIEIAGVGIK 635
Cdd:cd01450   78 GGTNTGKALQYALEQLFSESNARenvpKVIIVLTDGRSDD-GGDPKEAAAKLKDEGIKVFVVGVG 141
COG5137 COG5137
Histone chaperone involved in gene silencing [Transcription / Chromatin structure and dynamics] ...
 247-345 5.54e-04

Histone chaperone involved in gene silencing [Transcription / Chromatin structure and dynamics];


Pssm-ID: 227466 [Multi-domain]  Cd Length: 279  Bit Score: 42.29  E-value: 5.54e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504876031 247 ERLRDEAKEKQQEEDQNKDPQNDTDNSSGSENEPDSETNGDNQGEGDGDSEEQDDDAGNGkapmeDNEPSEQSKGDEESA 326
Cdd:COG5137  179 EERLEESDGREEEEDEEVGSDSYGEGNRELNEEEEEEAEGSDDGEDVVDYEGERIDKKQG-----EEEEMEEEVINLFEI 253

                         90
                 ....*....|....*....
gi 504876031 327 ESGNGEPDGEPETDESANP 345
Cdd:COG5137  254 EWEEESPSEEVPRNNEESP 272
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 247-344 5.99e-04

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 43.06  E-value: 5.99e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504876031   247 ERLRDEAKEKQQEEDQNKD-PQNDTDNSSGSENEPDSETNGDNQGEGDGDSE-------EQDDDAGNGKAPMEDNEPSEQ 318
Cdd:TIGR00927  643 ERTGEEGERPTEAEGENGEeSGGEAEQEGETETKGENESEGEIPAERKGEQEgegeieaKEADHKGETEAEEVEHEGETE 722

                           90       100
                   ....*....|....*....|....*.
gi 504876031   319 SKGDEESAESGNGEpDGEPETDESAN 344
Cdd:TIGR00927  723 AEGTEDEGEIETGE-EGEEVEDEGEG 747
VWA_integrin_invertebrates cd01476
VWA_integrin (invertebrates): Integrins are a family of cell surface receptors that have ...
 501-640 7.23e-04

VWA_integrin (invertebrates): Integrins are a family of cell surface receptors that have diverse functions in cell-cell and cell-extracellular matrix interactions. Because of their involvement in many biologically important adhesion processes, integrins are conserved across a wide range of multicellular animals. Integrins from invertebrates have been identified from six phyla. There are no data to date to suggest any immunological functions for the invertebrate integrins. The members of this sub-group have the conserved MIDAS motif that is charateristic of this domain suggesting the involvement of the integrins in the recognition and binding of multi-ligands.


Pssm-ID: 238753 [Multi-domain]  Cd Length: 163  Bit Score: 40.85  E-value: 7.23e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504876031 501 LVIVRDISGSmiLDHRYIHAIK--TDLALTLAIeANSKMHVANVIYPFVDKDFEVIKTFDENAEETLSK--FSLGCKGNN 576
Cdd:cd01476    3 LLFVLDSSGS--VRGKFEKYKKyiERIVEGLEI-GPTATRVALITYSGRGRQRVRFNLPKHNDGEELLEkvDNLRFIGGT 79

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 504876031 577 TPTGSALMAAVELLLESQFDR----KIVFLITDGYPTESDYTISDVLTvaESNGIEIAGVGIKTDELI 640
Cdd:cd01476   80 TATGAAIEVALQQLDPSEGRRegipKVVVVLTDGRSHDDPEKQARILR--AVPNIETFAVGTGDPGTV 145
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 251-349 1.32e-03

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 41.90  E-value: 1.32e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504876031   251 DEAKEKQQEEDQNKDPQNDTDNSSGSEnepDSETNGDNQGEGDGDSEEQDDDAGNGKAPMEDNEPSEQSKGDEESAESgn 330
Cdd:TIGR00927  807 TEAGEKDEHEGQSETQADDTEVKDETG---EQELNAENQGEAKQDEKGVDGGGGSDGGDSEEEEEEEEEEEEEEEEEE-- 881

                           90
                   ....*....|....*....
gi 504876031   331 gepDGEPETDESANPDSYD 349
Cdd:TIGR00927  882 ---EEEEEEEENEEPLSLE 897
vWA_BatA_type cd01467
VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood ...
 501-654 1.78e-03

VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of fold. The vWA domain, since its discovery, has drawn great interest because of its widespread occurrence and its involvement in a wide variety of important cellular functions. These include basal membrane formation, cell migration, cell differentiation, adhesion, haemostasis, signaling, chromosomal stability, malignant transformation and in immune defenses. In integrins these domains form heterodimers while in vWF it forms multimers. There are different interaction surfaces of this domain as seen by the various molecules it complexes with. Ligand binding in most cases is mediated by the presence of a metal ion dependent adhesion site termed as the MIDAS motif that is a characteristic feature of most, if not all A domains. Members of this subgroup are bacterial in origin. They are typified by the presence of a MIDAS motif.


Pssm-ID: 238744 [Multi-domain]  Cd Length: 180  Bit Score: 40.01  E-value: 1.78e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504876031 501 LVIVRDISGSMiLDHRYIHAIKTDLALTLAIEANSKMHVANV-IYPFVDK---------DFEVIKTFDENAEETLSkfsl 570
Cdd:cd01467    5 IMIALDVSGSM-LAQDFVKPSRLEAAKEVLSDFIDRRENDRIgLVVFAGAaftqapltlDRESLKELLEDIKIGLA---- 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504876031 571 gckGNNTPTGSALMAAVELLLESQFDRKIVFLITDGYPTESDYTISDVLTVAESNGIEIAGVGIKTDELIGFDEGTFVNV 650
Cdd:cd01467   80 ---GQGTAIGDAIGLAIKRLKNSEAKERVIVLLTDGENNAGEIDPATAAELAKNKGVRIYTIGVGKSGSGPKPDGSTILD 156


                 ....
gi 504876031 651 DDIS 654
Cdd:cd01467  157 EDSL 160
COG4867 COG4867
Uncharacterized conserved protein, contains von Willebrand factor type A (vWFA) domain ...
 481-609 2.13e-03

Uncharacterized conserved protein, contains von Willebrand factor type A (vWFA) domain [Function unknown];


Pssm-ID: 443895 [Multi-domain]  Cd Length: 371  Bit Score: 40.93  E-value: 2.13e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504876031 481 MGVRDVFRSQSESKNRGHVGLVIvrDISGSMILDHRYIHAIKTDLALtlaieanskmhvANVI---YPfvdKD-FEVIkT 556
Cdd:COG4867  165 LDEEDLEVEETEYRTQAATVLMV--DTSHSMILYGRWTPAKKVALAL------------AHLIrtrFP---GDtLDII-V 226

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 504876031 557 FDENAEE-TLSKF----SLGCKGNNTPTGsaLMAAVELLLESQFDRKIVFLITDGYPT 609
Cdd:COG4867  227 FGNDAWEvEIKELpylqWVGPYGTNTHHG--LLLARRLLRRHPNANKQILMITDGEPT 282
MDN1 COG5271
Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal ...
 250-403 2.42e-03

Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444083 [Multi-domain]  Cd Length: 1028  Bit Score: 41.15  E-value: 2.42e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504876031  250 RDEAKEKQQEEDQNKDPQNDTDNSSGSENEPDSETNGDNQGEGDGDSEEQDDDAGNGKAPMEDNEPSEQSKGDEESAESG 329
Cdd:COG5271   666 EEEAEDESETSSEDAEEDADAAAAEASDDEEETEEADEDAETASEEADAEEADTEADGTAEEAEEAAEEAESADEEAASL 745

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 504876031  330 NGEPDGEPETDESANPDSYDADGTPSQIDSSNGNPSDGESNFSPEQWSILAKLLDDFLNSDEESEDFHEALANE 403
Cdd:COG5271   746 PDEADAEEEAEEAEEAEEDDADGLEEALEEEKADAEEAATDEEAEAAAEEKEKVADEDQDTDEDALLDEAEADE 819
COG5644 COG5644
U3 small nucleolar RNA-associated protein 14 [Function unknown];
247-475 6.18e-03

U3 small nucleolar RNA-associated protein 14 [Function unknown];


Pssm-ID: 227931 [Multi-domain]  Cd Length: 869  Bit Score: 39.69  E-value: 6.18e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504876031 247 ERLRDEAKEKQQEEDQNKDPQNDTDNSSGSENEPDSETNGDNQGEGDGDSEEQDDDAGNGKAPMEDNEPSEQSkgdeesa 326
Cdd:COG5644   68 KRFADWSFNASKSGKSNKDHKNLNNTKEISLNDSDDSVNSDKLENEGSVSSIDENELVDLDTLLDNDQPEKNE------- 140

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504876031 327 eSGNGEPDGEPE-----TDESANPDSYDADGTPSQIDSSNGNPSD--GESNFSPEQWSILAKLLDDF-LNSDEESEDFHE 398
Cdd:COG5644  141 -SGNNDHATDKEnllesDASSSNDSESEESDSESEIESSDSDHDDenSDSKLDNLRNYIVSLKKDEAdAESVLSSDDNDS 219

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504876031 399 ALANEIsviaasVSDEVKAEFGANE-WDLPDLL--IDLNVYNEALN--ISQTLGADLSVLQQVKMRgqfktRDRGLSFDI 473
Cdd:COG5644  220 IEEIKY------DPHETNKESGSSEtIDITDLLdsIPMEQLKVSLKplVSESSKLDAPLAKSIQDR-----LERQAAYEQ 288


                 ..
gi 504876031 474 NR 475
Cdd:COG5644  289 TK 290
VWA_2 pfam13519
von Willebrand factor type A domain;
501-603 7.85e-03

von Willebrand factor type A domain;


Pssm-ID: 463909 [Multi-domain]  Cd Length: 103  Bit Score: 36.50  E-value: 7.85e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504876031  501 LVIVRDISGSM---ILDHRYIHAIKTdlALTLAIEANSKMHVAnVIypFVDKDFEVIKTFDENAEETLSKF-SLGCKGNN 576
Cdd:pfam13519   1 LVFVLDTSGSMrngDYGPTRLEAAKD--AVLALLKSLPGDRVG-LV--TFGDGPEVLIPLTKDRAKILRALrRLEPKGGG 75

                          90       100
                  ....*....|....*....|....*...
gi 504876031  577 TPTGSALMAAVELLLESQFD-RKIVFLI 603
Cdd:pfam13519  76 TNLAAALQLARAALKHRRKNqPRRIVLI 103
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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