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Conserved domains on  [gi|505054449|ref|WP_015241551|]
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transposase [Sinorhizobium meliloti]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
transpos_IS66 super family cl41296
IS66 family transposase; Members of this protein family are DDE transposases from the IS66 ...
 369-535 2.48e-19

IS66 family transposase; Members of this protein family are DDE transposases from the IS66 family insertion sequences, which typically consist of two accessary genes (TnpA and TnpB) and the third gene encoding the transposase.


The actual alignment was detected with superfamily member NF033517:

Pssm-ID: 468053 [Multi-domain]  Cd Length: 388  Bit Score: 89.95  E-value: 2.48e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505054449 369 VIVSDD-AGQFRVA--NHALCWIHAERLLQKLMPATPKQ--ERLVTTTRDL--VWRFYKAL-----KVWKQQPSPQLITG 436
Cdd:NF033517 207 VLQSDGyAGYNKLAavTHAGCWAHLRRKFQEAAERKGKSiaEEALKRIGELyaIERRIRGLspeerRALRQERSRPLLDE 286

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505054449 437 FRHRFDKIFARRTGFTELDKLLLRLHRRKAELLKVLEHPYIPLHTNASENDIRSFVTRRKISGGTISLNGRIARDVMLGL 516
Cdd:NF033517 287 LKAWLEAGLAGVLPKSPLGKAIRYLLNRWDALLRFLDDGRVPIDNNAAERAIRPVVLGRKNSLFAGSDRGAEAAARIYSL 366

                        170
                 ....*....|....*....
gi 505054449 517 MKTCQKLGISFYHFLGDRL 535
Cdd:NF033517 367 IETAKLNGLNPYAYLRDVL 385
ZapB COG3074
Cell division protein ZapB, interacts with FtsZ [Cell cycle control, cell division, chromosome ...
 11-78 1.36e-06

Cell division protein ZapB, interacts with FtsZ [Cell cycle control, cell division, chromosome partitioning];


:

Pssm-ID: 442308 [Multi-domain]  Cd Length: 79  Bit Score: 46.12  E-value: 1.36e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 505054449  11 VETLSLLAMRrlvgglVEEL----HALKAEVATLRSENEALREDNAQrrldnarLKAENQQLRDEIARLNNL 78
Cdd:COG3074   17 VDTIELLQME------VEELkeknEELEQENEELQSENEELQSENEQ-------LKTENAEWQERIRSLLGK 75
 
Name Accession Description Interval E-value
transpos_IS66 NF033517
IS66 family transposase; Members of this protein family are DDE transposases from the IS66 ...
 369-535 2.48e-19

IS66 family transposase; Members of this protein family are DDE transposases from the IS66 family insertion sequences, which typically consist of two accessary genes (TnpA and TnpB) and the third gene encoding the transposase.


Pssm-ID: 468053 [Multi-domain]  Cd Length: 388  Bit Score: 89.95  E-value: 2.48e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505054449 369 VIVSDD-AGQFRVA--NHALCWIHAERLLQKLMPATPKQ--ERLVTTTRDL--VWRFYKAL-----KVWKQQPSPQLITG 436
Cdd:NF033517 207 VLQSDGyAGYNKLAavTHAGCWAHLRRKFQEAAERKGKSiaEEALKRIGELyaIERRIRGLspeerRALRQERSRPLLDE 286

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505054449 437 FRHRFDKIFARRTGFTELDKLLLRLHRRKAELLKVLEHPYIPLHTNASENDIRSFVTRRKISGGTISLNGRIARDVMLGL 516
Cdd:NF033517 287 LKAWLEAGLAGVLPKSPLGKAIRYLLNRWDALLRFLDDGRVPIDNNAAERAIRPVVLGRKNSLFAGSDRGAEAAARIYSL 366

                        170
                 ....*....|....*....
gi 505054449 517 MKTCQKLGISFYHFLGDRL 535
Cdd:NF033517 367 IETAKLNGLNPYAYLRDVL 385
DDE_Tnp_IS66 pfam03050
Transposase IS66 family; Transposase proteins are necessary for efficient DNA transposition. ...
 367-506 3.75e-11

Transposase IS66 family; Transposase proteins are necessary for efficient DNA transposition. This family includes IS66 from Agrobacterium tumefaciens.


Pssm-ID: 427113 [Multi-domain]  Cd Length: 281  Bit Score: 63.81  E-value: 3.75e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505054449  367 STVIVSDD-AGQFRVAN----HALCWIHAERLLQKlmpATPKQERLVTTTRDLVWRFYKALKVWKQQPSPQ--------- 432
Cdd:pfam03050 126 RGVLQTDGyAGYNKLARgqvtHAGCWAHARRKFFD---AHKAGSPLAAQALARIGKLYAIEREIRDLTPEErlalrqeys 202

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 505054449  433 --LITGFRHRFDKIFARRTGFTELDKLLLRLHRRKAELLKVLEHPYIPLHTNASENDIRSFVTRRKISGGTISLNG 506
Cdd:pfam03050 203 rpLLDELEAWLEEQLRGVLPKSALGKAIRYLLNRWEALLRFLEDGRVPIDNNQAERAIRPVVLGRKNWLFAGSDEG 278
ZapB COG3074
Cell division protein ZapB, interacts with FtsZ [Cell cycle control, cell division, chromosome ...
 11-78 1.36e-06

Cell division protein ZapB, interacts with FtsZ [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442308 [Multi-domain]  Cd Length: 79  Bit Score: 46.12  E-value: 1.36e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 505054449  11 VETLSLLAMRrlvgglVEEL----HALKAEVATLRSENEALREDNAQrrldnarLKAENQQLRDEIARLNNL 78
Cdd:COG3074   17 VDTIELLQME------VEELkeknEELEQENEELQSENEELQSENEQ-------LKTENAEWQERIRSLLGK 75
ZapB pfam06005
Cell division protein ZapB; ZapB is a non-essential, abundant cell division factor that is ...
 26-78 2.12e-06

Cell division protein ZapB; ZapB is a non-essential, abundant cell division factor that is required for proper Z-ring formation.


Pssm-ID: 428718 [Multi-domain]  Cd Length: 71  Bit Score: 45.33  E-value: 2.12e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 505054449   26 LVEELHALKAEVATLRSENEALREDNAQRRLDNARLKAENQQLRDE----IARLNNL 78
Cdd:pfam06005   9 LETKIQAAVDTIALLQMENEELKEENEELKEEANELEEENQQLKQErnqwQERIRGL 65
cc_RasGRP1_C cd22290
C-terminal coiled-coil domain of RAS guanyl-releasing protein 1 (RasGRP1) and similar proteins; ...
 29-71 3.34e-04

C-terminal coiled-coil domain of RAS guanyl-releasing protein 1 (RasGRP1) and similar proteins; RasGRP1, also called calcium and DAG-regulated guanine nucleotide exchange factor II (CalDAG-GEFII), or Ras guanyl-releasing protein, acts as a calcium- and diacylglycerol (DAG)-regulated nucleotide exchange factor, specifically activating Ras through the exchange of bound GDP for GTP. This model corresponds to the C-terminal coiled-coil domain of RasGRP1, which mediates oligomerization.


Pssm-ID: 412086  Cd Length: 55  Bit Score: 38.57  E-value: 3.34e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 505054449  29 ELHALKAEVATLRSENEALRE--DNAQRRLDNARLKAENQQLRDE 71
Cdd:cd22290    9 TYQELEKENSNLKAENEALKIqlKDAQRRIEALRLELRKHVLDNL 53
PRK13922 PRK13922
rod shape-determining protein MreC; Provisional
 18-86 6.81e-03

rod shape-determining protein MreC; Provisional


Pssm-ID: 237560  Cd Length: 276  Bit Score: 38.81  E-value: 6.81e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 505054449  18 AMRRLVGGLVEELHALKaevaTLRSENEALREDNA---QRRLDNARLKAENQQLRDeiarLNNLPPRPPFRP 86
Cdd:PRK13922  56 APREFVSGVFESLASLF----DLREENEELKKELLeleSRLQELEQLEAENARLRE----LLNLKESLDYQF 119
 
Name Accession Description Interval E-value
transpos_IS66 NF033517
IS66 family transposase; Members of this protein family are DDE transposases from the IS66 ...
 369-535 2.48e-19

IS66 family transposase; Members of this protein family are DDE transposases from the IS66 family insertion sequences, which typically consist of two accessary genes (TnpA and TnpB) and the third gene encoding the transposase.


Pssm-ID: 468053 [Multi-domain]  Cd Length: 388  Bit Score: 89.95  E-value: 2.48e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505054449 369 VIVSDD-AGQFRVA--NHALCWIHAERLLQKLMPATPKQ--ERLVTTTRDL--VWRFYKAL-----KVWKQQPSPQLITG 436
Cdd:NF033517 207 VLQSDGyAGYNKLAavTHAGCWAHLRRKFQEAAERKGKSiaEEALKRIGELyaIERRIRGLspeerRALRQERSRPLLDE 286

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505054449 437 FRHRFDKIFARRTGFTELDKLLLRLHRRKAELLKVLEHPYIPLHTNASENDIRSFVTRRKISGGTISLNGRIARDVMLGL 516
Cdd:NF033517 287 LKAWLEAGLAGVLPKSPLGKAIRYLLNRWDALLRFLDDGRVPIDNNAAERAIRPVVLGRKNSLFAGSDRGAEAAARIYSL 366

                        170
                 ....*....|....*....
gi 505054449 517 MKTCQKLGISFYHFLGDRL 535
Cdd:NF033517 367 IETAKLNGLNPYAYLRDVL 385
DDE_Tnp_IS66 pfam03050
Transposase IS66 family; Transposase proteins are necessary for efficient DNA transposition. ...
 367-506 3.75e-11

Transposase IS66 family; Transposase proteins are necessary for efficient DNA transposition. This family includes IS66 from Agrobacterium tumefaciens.


Pssm-ID: 427113 [Multi-domain]  Cd Length: 281  Bit Score: 63.81  E-value: 3.75e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505054449  367 STVIVSDD-AGQFRVAN----HALCWIHAERLLQKlmpATPKQERLVTTTRDLVWRFYKALKVWKQQPSPQ--------- 432
Cdd:pfam03050 126 RGVLQTDGyAGYNKLARgqvtHAGCWAHARRKFFD---AHKAGSPLAAQALARIGKLYAIEREIRDLTPEErlalrqeys 202

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 505054449  433 --LITGFRHRFDKIFARRTGFTELDKLLLRLHRRKAELLKVLEHPYIPLHTNASENDIRSFVTRRKISGGTISLNG 506
Cdd:pfam03050 203 rpLLDELEAWLEEQLRGVLPKSALGKAIRYLLNRWEALLRFLEDGRVPIDNNQAERAIRPVVLGRKNWLFAGSDEG 278
ZapB COG3074
Cell division protein ZapB, interacts with FtsZ [Cell cycle control, cell division, chromosome ...
 11-78 1.36e-06

Cell division protein ZapB, interacts with FtsZ [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442308 [Multi-domain]  Cd Length: 79  Bit Score: 46.12  E-value: 1.36e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 505054449  11 VETLSLLAMRrlvgglVEEL----HALKAEVATLRSENEALREDNAQrrldnarLKAENQQLRDEIARLNNL 78
Cdd:COG3074   17 VDTIELLQME------VEELkeknEELEQENEELQSENEELQSENEQ-------LKTENAEWQERIRSLLGK 75
ZapB pfam06005
Cell division protein ZapB; ZapB is a non-essential, abundant cell division factor that is ...
 26-78 2.12e-06

Cell division protein ZapB; ZapB is a non-essential, abundant cell division factor that is required for proper Z-ring formation.


Pssm-ID: 428718 [Multi-domain]  Cd Length: 71  Bit Score: 45.33  E-value: 2.12e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 505054449   26 LVEELHALKAEVATLRSENEALREDNAQRRLDNARLKAENQQLRDE----IARLNNL 78
Cdd:pfam06005   9 LETKIQAAVDTIALLQMENEELKEENEELKEEANELEEENQQLKQErnqwQERIRGL 65
ZapB COG3074
Cell division protein ZapB, interacts with FtsZ [Cell cycle control, cell division, chromosome ...
 23-78 6.72e-05

Cell division protein ZapB, interacts with FtsZ [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442308 [Multi-domain]  Cd Length: 79  Bit Score: 41.50  E-value: 6.72e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 505054449  23 VGGLVEELHALKAEVATLRSENEALREDNAQRRLDNARLKAENQQLRDEIA----RLNNL 78
Cdd:COG3074   13 VQQAVDTIELLQMEVEELKEKNEELEQENEELQSENEELQSENEQLKTENAewqeRIRSL 72
MreC COG1792
Cell shape-determining protein MreC [Cell cycle control, cell division, chromosome ...
 35-85 1.79e-04

Cell shape-determining protein MreC [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 441397  Cd Length: 282  Bit Score: 43.72  E-value: 1.79e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 505054449  35 AEVATLRSENEALREDNAQRRLDNAR---LKAENQQLRDeiarLNNLPPRPPFR 85
Cdd:COG1792   68 RSLFNLREENERLKEENAELRAELQRleeLEAENARLRE----LLDLKERLDYK 117
cc_RasGRP1_C cd22290
C-terminal coiled-coil domain of RAS guanyl-releasing protein 1 (RasGRP1) and similar proteins; ...
 29-71 3.34e-04

C-terminal coiled-coil domain of RAS guanyl-releasing protein 1 (RasGRP1) and similar proteins; RasGRP1, also called calcium and DAG-regulated guanine nucleotide exchange factor II (CalDAG-GEFII), or Ras guanyl-releasing protein, acts as a calcium- and diacylglycerol (DAG)-regulated nucleotide exchange factor, specifically activating Ras through the exchange of bound GDP for GTP. This model corresponds to the C-terminal coiled-coil domain of RasGRP1, which mediates oligomerization.


Pssm-ID: 412086  Cd Length: 55  Bit Score: 38.57  E-value: 3.34e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 505054449  29 ELHALKAEVATLRSENEALRE--DNAQRRLDNARLKAENQQLRDE 71
Cdd:cd22290    9 TYQELEKENSNLKAENEALKIqlKDAQRRIEALRLELRKHVLDNL 53
ZIP_MycBP-like cd21937
leucine zipper domain found in c-Myc-binding protein and similar proteins; MycBP, also called ...
 35-76 3.78e-03

leucine zipper domain found in c-Myc-binding protein and similar proteins; MycBP, also called associate of Myc 1 (AMY-1), is a novel c-Myc binding protein that may control the transcriptional activity of Myc. It stimulates the activation of E box-dependent transcription by Myc. This model corresponds to the conserved region that shows high sequence similarity with the leucine zipper (ZIP) domain located at the C-terminus of TGF-beta-stimulated clone-22 domain (TSC22D) family transcription factors. The first helix of ZIP is not basic and does not contain the consensus sequence, NXX(A)(A)XX(C/S)R, found in most basic region/leucine zipper (bZIP) proteins. Thus, the DNA-binding capability of the ZIP domain is not obvious. Similar to bZIP, ZIP forms homo- and heterodimers, resulting in many dimers that may have different effects on transcription.


Pssm-ID: 409277 [Multi-domain]  Cd Length: 53  Bit Score: 35.60  E-value: 3.78e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 505054449  35 AEVATLRSENEALREDNAQrrldnarLKAENQQLRDEIARLN 76
Cdd:cd21937   19 ADVEALRLENEELKQKNEE-------LEEENKELKAKLQQYE 53
Atg16_CCD cd22887
Coiled-coiled domain of autophagy-related 16 (Atg16) family proteins; The Atg16 family ...
 26-76 5.53e-03

Coiled-coiled domain of autophagy-related 16 (Atg16) family proteins; The Atg16 family includes Saccharomyces cerevisiae Atg16 (also called cytoplasm to vacuole targeting protein 11, CVT11, or SAP18), human autophagy-related protein 16-1 (also called APG16-like 1, ATG16L1, or APG16L) and autophagy-related protein 16-2 (also called APG16-like 2, ATG16L2, WD repeat-containing protein 80 or WDR80), and similar proteins. Atg16 stabilizes the Atg5-Atg12 conjugate and mediates the formation of the 350 kDa complex, which is necessary for autophagy. The Atg5-Atg12/Atg16 complex is required for efficient promotion of Atg8-conjugation to phosphatidylethanolamine and Atg8 localization to the pre-autophagosomal structure (PAS). Similarly, human ATG16L1 plays an essential role in autophagy and acts as a molecular scaffold which mediates protein-protein interactions essential for autophagosome formation. ATG16L2, though structurally similar to ATG16L1 and able to form a complex with the autophagy proteins Atg5 and Atg12, is not essential for autophagy. Single-nucleotide polymorphisms in ATG16L1 is associated with an increased risk of developing Crohn disease. Saccharomyces cerevisiae Atg16 contains an N-terminal domain (NTD) that interacts with the Atg5-Atg12 protein conjugate and a coiled-coil domain (CCD) that dimerizes and mediates self-assembly. Human ATG16L1 and ATG16L2 also contains an N-terminal region that binds Atg5, a CCD homologous to the yeast CCD, and a WD40 domain that represents approximately 50% of the full-length protein. This model corresponds to the CCD of Atg16 family proteins.


Pssm-ID: 439196 [Multi-domain]  Cd Length: 91  Bit Score: 36.39  E-value: 5.53e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 505054449  26 LVEELHALKAEVATLRSENEALREDNAQRRLDNARLKAENQQLRDEIARLN 76
Cdd:cd22887    2 LESELQELEKRLAELEAELASLEEEIKDLEEELKEKNKANEILNDELIALQ 52
PRK13922 PRK13922
rod shape-determining protein MreC; Provisional
 18-86 6.81e-03

rod shape-determining protein MreC; Provisional


Pssm-ID: 237560  Cd Length: 276  Bit Score: 38.81  E-value: 6.81e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 505054449  18 AMRRLVGGLVEELHALKaevaTLRSENEALREDNA---QRRLDNARLKAENQQLRDeiarLNNLPPRPPFRP 86
Cdd:PRK13922  56 APREFVSGVFESLASLF----DLREENEELKKELLeleSRLQELEQLEAENARLRE----LLNLKESLDYQF 119
FtsB COG2919
Cell division protein FtsB [Cell cycle control, cell division, chromosome partitioning];
46-79 8.45e-03

Cell division protein FtsB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442163 [Multi-domain]  Cd Length: 96  Bit Score: 36.01  E-value: 8.45e-03
                         10        20        30
                 ....*....|....*....|....*....|....
gi 505054449  46 ALREDNAQRRLDNARLKAENQQLRDEIARLNNLP 79
Cdd:COG2919   33 ELRQEIAELEAENAKLKARNAELEAEVADLKDGP 66
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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