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Conserved domains on  [gi|505162042|ref|WP_015349144|]
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ATPase, T2SS/T4P/T4SS family [Myxococcus stipitatus]

Protein Classification

FHA and VirB11-like_ATPase domain-containing protein( domain architecture ID 10044430)

FHA and VirB11-like_ATPase domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CpaF COG4962
Pilus assembly protein, ATPase of CpaF family [Intracellular trafficking, secretion, and ...
 196-583 0e+00

Pilus assembly protein, ATPase of CpaF family [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


:

Pssm-ID: 443988 [Multi-domain]  Cd Length: 386  Bit Score: 552.08  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505162042 196 DRLGDDELWRRTEKAIRDIIdqmEADGELPEDVDREELLTDVINEALGLGPLEAFLASDEISEIMVNHANQIYIERKGKL 275
Cdd:COG4962   11 RRLDREELREEVRAAVAEAL---RAEGLVLSDAEREALARAVLDELFGLGPLEPLLDDPDVTDIMVNGPDEVFVERGGRL 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505162042 276 TLSEKTFSSNQAVLGVIERIVAPIGRRIDESSPLVDARLKDGSRVNAIIPPLALKGPCITIRKFKKDSLKIQDLIKYKTL 355
Cdd:COG4962   88 ERTDVRFDSEEELRRLIERIAARVGRRLDESSPIVDARLPDGSRVNAVIPPVARDGPSLSIRKFRKRPLTLEDLVALGSL 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505162042 356 TAQMAEFLEMCVKARRNIVIsggtgsgktttLNIISAFIPDSERIVTVEDAAELQLPQDHWVQLESRPPNLEGKGAITIR 435
Cdd:COG4962  168 TPEMAEFLRAAVRARLNILVsggtgsgkttlLNALSGFIPPDERIVTIEDAAELQLQHPHVVRLETRPPNVEGAGEVTLR 247

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505162042 436 DLVKNCLRMRPDRIVVGECRSGETLDMLQAMNTGHDGSLTTLHANTPRDAIARLETMVLMSGMELPVKAIREQIASAVHM 515
Cdd:COG4962  248 DLVRNALRMRPDRIIVGEVRGAEALDMLQAMNTGHDGSMSTLHANSARDALARLETLALMAGENLPREAVRRQIASAIDL 327

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 505162042 516 IVQQTRFSDGTRKICFVTEVSGMEVDIVTLQDIFYYKQDGFTEDHKVRgrfvasgfvPKFYDELQRKG 583
Cdd:COG4962  328 VVHLERLRDGRRRVTEIAEVTGMEGGRVVLQPIFRFDPGGLDAAGGVR---------PRFLERLEAAG 386
FHA COG1716
Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms];
1-94 2.71e-24

Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms];


:

Pssm-ID: 441322 [Multi-domain]  Cd Length: 96  Bit Score: 97.34  E-value: 2.71e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505162042   1 MFLITLAEKGGGTEQREYHKPEITIGRLPGNDIMLAKGNVSKYHSRIVAKDGKCIIVDMKSTNGTFVNGKKIAAPQVLKP 80
Cdd:COG1716    1 MARLVVLEGPLAGRRFPLDGGPLTIGRAPDNDIVLDDPTVSRRHARIRRDGGGWVLEDLGSTNGTFVNGQRVTEPAPLRD 80

                         90
                 ....*....|....
gi 505162042  81 TDEIYIGDYIINVE 94
Cdd:COG1716   81 GDVIRLGKTELRFR 94
 
Name Accession Description Interval E-value
CpaF COG4962
Pilus assembly protein, ATPase of CpaF family [Intracellular trafficking, secretion, and ...
 196-583 0e+00

Pilus assembly protein, ATPase of CpaF family [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 443988 [Multi-domain]  Cd Length: 386  Bit Score: 552.08  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505162042 196 DRLGDDELWRRTEKAIRDIIdqmEADGELPEDVDREELLTDVINEALGLGPLEAFLASDEISEIMVNHANQIYIERKGKL 275
Cdd:COG4962   11 RRLDREELREEVRAAVAEAL---RAEGLVLSDAEREALARAVLDELFGLGPLEPLLDDPDVTDIMVNGPDEVFVERGGRL 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505162042 276 TLSEKTFSSNQAVLGVIERIVAPIGRRIDESSPLVDARLKDGSRVNAIIPPLALKGPCITIRKFKKDSLKIQDLIKYKTL 355
Cdd:COG4962   88 ERTDVRFDSEEELRRLIERIAARVGRRLDESSPIVDARLPDGSRVNAVIPPVARDGPSLSIRKFRKRPLTLEDLVALGSL 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505162042 356 TAQMAEFLEMCVKARRNIVIsggtgsgktttLNIISAFIPDSERIVTVEDAAELQLPQDHWVQLESRPPNLEGKGAITIR 435
Cdd:COG4962  168 TPEMAEFLRAAVRARLNILVsggtgsgkttlLNALSGFIPPDERIVTIEDAAELQLQHPHVVRLETRPPNVEGAGEVTLR 247

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505162042 436 DLVKNCLRMRPDRIVVGECRSGETLDMLQAMNTGHDGSLTTLHANTPRDAIARLETMVLMSGMELPVKAIREQIASAVHM 515
Cdd:COG4962  248 DLVRNALRMRPDRIIVGEVRGAEALDMLQAMNTGHDGSMSTLHANSARDALARLETLALMAGENLPREAVRRQIASAIDL 327

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 505162042 516 IVQQTRFSDGTRKICFVTEVSGMEVDIVTLQDIFYYKQDGFTEDHKVRgrfvasgfvPKFYDELQRKG 583
Cdd:COG4962  328 VVHLERLRDGRRRVTEIAEVTGMEGGRVVLQPIFRFDPGGLDAAGGVR---------PRFLERLEAAG 386
heli_sec_ATPase TIGR03819
helicase/secretion neighborhood ATPase; Members of this protein family comprise a distinct ...
 210-529 3.88e-89

helicase/secretion neighborhood ATPase; Members of this protein family comprise a distinct clade of putative ATPase associated with an integral membrane complex likely to act in pilus formation, secretion, or conjugal transfer. The association of most members with a nearby gene for a DEAH-box helicase suggests a role in conjugal transfer.


Pssm-ID: 200328  Cd Length: 340  Bit Score: 279.22  E-value: 3.88e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505162042  210 AIRDIIDQMEADGELPEDVdrEELLTDVInealGLGPLEAFLASDEISEIMVNHANQIYIERKGKLTLSEKTFSSNQAVL 289
Cdd:TIGR03819  24 AVRAEAGRVLGDAEVLAAA--RALRRDLV----GAGPLEPLLADPGVTDVLVNGPDEVWVDRGRGLERTDVRFPDEAAVR 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505162042  290 GVIERIVAPIGRRIDESSPLVDARLKDGSRVNAIIPPLALKGPCITIRKFKKDSLKIQDLIKYKTLTAQMAEFLEMCVKA 369
Cdd:TIGR03819  98 RLAQRLAAAAGRRLDDAQPWVDARLPDGTRLHAVLPPVATDGTCLSLRVPRRRTFTLDELVAAGTIPPGVARLLRALVAA 177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505162042  370 RRNIVISGGTGSGKTTTLNIISAFIPDSERIVTVEDAAELQLPQDHWVQLESRPPNLEGKGAITIRDLVKNCLRMRPDRI 449
Cdd:TIGR03819 178 RLAFLVSGGTGSGKTTLLSALLALVPPDERIVLVEDAAELRPDHPHVVRLEARPANVEGAGAVTLTDLVRQALRMRPDRI 257

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505162042  450 VVGECRSGETLDMLQAMNTGHDGSLTTLHANTPRDAIARLETMVLMSGMELPvkAIREQIASAVHMIVQQTRFSDGTRKI 529
Cdd:TIGR03819 258 VVGEVRGAEVVDLLAALNTGHDGGAGTLHANSPADVPARLEALGALAGLDRA--ALHSQLAAALDVVLHVRRTPRGRRRV 335
VirB11-like_ATPase cd01130
Type IV secretory pathway component VirB11-like; Type IV secretory pathway component VirB11, ...
 359-535 2.75e-73

Type IV secretory pathway component VirB11-like; Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir (virulence) proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the bacterial Ti (tumor-inducing)-plasmid into plant cells. The pilus is a fibrous cell surface organelle, which mediates adhesion between bacteria during conjugative transfer or between bacteria and host eukaryotic cells during infection. VirB11-related ATPases include Sulfolobus acidocaldarius FlaI, which plays key roles in archaellum (archaeal flagellum) assembly and motility functions, and the pilus assembly proteins CpaF/TadA and TrbB. This alignment contains the C-terminal domain, which is the ATPase.


Pssm-ID: 410874 [Multi-domain]  Cd Length: 177  Bit Score: 232.05  E-value: 2.75e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505162042 359 MAEFLEMCVKARRNIVISGGTGSGKTTTLNIISAFIPDSERIVTVEDAAELQLPQDHWVQLESRPPNLEgKGAITIRDLV 438
Cdd:cd01130    1 MAAFLRLAVRARKNILISGGTGSGKTTLLNALLSFIPPDERIVTIEDTRELQLPHPNVVHLLTRPGGGE-KGEVTMADLL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505162042 439 KNCLRMRPDRIVVGECRSGETLDMLQAMNTGHDGSLTTLHANTPRDAIARLETMVLMSGMELPVKAIREQIASAVHMIVQ 518
Cdd:cd01130   80 KAALRMRPDRIIVGEVRGGEAYDMLQAMNTGHPGSITTIHANSAEDAIDRLATLVLEAGVNLDEEALRRLIASAIDVIVH 159

                        170
                 ....*....|....*..
gi 505162042 519 QTRFSDGTRKICFVTEV 535
Cdd:cd01130  160 VKRLGDGVRRVTEIYEV 176
T2SSE pfam00437
Type II/IV secretion system protein; This family contains components of both the Type II ...
 243-519 1.33e-60

Type II/IV secretion system protein; This family contains components of both the Type II protein secretion system (T2SS), including Type 4 pilus (T4P), and Type IV protein secretion system (T4SS) from Gram-negative bacteria. VirB11 ATPase is a subunit of the Agrobacterium tumefaciens transfer DNA (T-DNA) transfer system, a type IV secretion pathway required for delivery of T-DNA and effector proteins to plant cells during infection. The cytoplasmic T2S E ATPase is a Zn-containing protein thought to provide the mechanical force for the secretion process. T2S-E contains Walker A and B motifs, that are essential for secretion and ATPase activity. ATPase PulE and XcpR from Klebsiella oxytoca and Pseudomonas aeruginosa respectively are required for protein secretion via the T2SS. ATPase PilB is required for T4P extension.


Pssm-ID: 425681 [Multi-domain]  Cd Length: 269  Bit Score: 202.13  E-value: 1.33e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505162042  243 GLGPLEAFLASdeISEIMVNHANQIYI--ERKGKlTLSEKTFSSNQAVLGVIERIVAPIGRRIDESSPLVDARLK----- 315
Cdd:pfam00437   1 NLIPLEALDEG--ASDIHVEPPERIVWirFRVDG-VLREIPFPDADALARLISRIKVMARLDISERRPPQDGRLPlrigg 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505162042  316 DGSRVNAIIPPLALkGPCITIRKFKKDS--LKIQDLIKYKTLTAQMAEFLEmcvKARRNIVISGGTGSGKTTTLNIISAF 393
Cdd:pfam00437  78 KGVRVRVSTLPTAG-GEKLVIRLLDPSNvaLSLDELGMTGAQDEALLEFLR---QPRGNILVTGPTGSGKTTTLYAALGE 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505162042  394 IP-DSERIVTVEDAAELQLPQDHWVQLESRppnlegkGAITIRDLVKNCLRMRPDRIVVGECRSGETLDM-LQAMNTGHD 471
Cdd:pfam00437 154 LNtRDENIVTVEDPVEIQLEGINQVQLNAR-------AGVTFADLLRAILRQDPDRIMVGEIRDLETAEIaLQAANTGHL 226

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 505162042  472 GsLTTLHANTPRDAIARLETMVlmsgmeLPVKAIREQIASAvhmIVQQ 519
Cdd:pfam00437 227 V-LSTLHTNSAAGALTRLQDMG------VPPFELASSLLLV---IAQR 264
PRK13900 PRK13900
type IV secretion system ATPase VirB11; Provisional
 244-535 2.76e-46

type IV secretion system ATPase VirB11; Provisional


Pssm-ID: 184381  Cd Length: 332  Bit Score: 166.09  E-value: 2.76e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505162042 244 LGPLEAFLASDEISEIMVNHANQIYIERKGKLtLSEKTFSSNQAVLGVIERIVA-PIGRRIDESSPLVDARLKDGSRVNA 322
Cdd:PRK13900  12 LEPLKNIFAEDGVNEISINKPGEVWVEKKGDI-RCEQIPELDLSHLKALGRLVAqATEQKISEEKPLLSATLPNGYRIQI 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505162042 323 IIPPLALKGPCI-TIRK-------------------FKKDSLKIQDLIKYKTLTAQ--MAEFLEMCVKARRNIVISGGTG 380
Cdd:PRK13900  91 VFPPACEIGQIVySIRKpsgmqltlddyekmgafdeTATESLVDEDDVILNELLAEkkIKEFLEHAVISKKNIIISGGTS 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505162042 381 SGKTTTLNIISAFIPDSERIVTVEDAAELQLPqDH--WVQLESRPPNlEGKGAITIRDLVKNCLRMRPDRIVVGECRSGE 458
Cdd:PRK13900 171 TGKTTFTNAALREIPAIERLITVEDAREIVLS-NHpnRVHLLASKGG-QGRAKVTTQDLIEACLRLRPDRIIVGELRGAE 248

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 505162042 459 TLDMLQAMNTGHDGSLTTLHANTPRDAIARLETMVLMSGMELPVKAIREQIASAVHMIVQQTRFSDGTRkicFVTEV 535
Cdd:PRK13900 249 AFSFLRAINTGHPGSISTLHADSPAMAIEQLKLMVMQAGLGMPPDQIKKYILNVVDIVVQLKRGSGGKR---YVSEI 322
FHA COG1716
Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms];
1-94 2.71e-24

Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms];


Pssm-ID: 441322 [Multi-domain]  Cd Length: 96  Bit Score: 97.34  E-value: 2.71e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505162042   1 MFLITLAEKGGGTEQREYHKPEITIGRLPGNDIMLAKGNVSKYHSRIVAKDGKCIIVDMKSTNGTFVNGKKIAAPQVLKP 80
Cdd:COG1716    1 MARLVVLEGPLAGRRFPLDGGPLTIGRAPDNDIVLDDPTVSRRHARIRRDGGGWVLEDLGSTNGTFVNGQRVTEPAPLRD 80

                         90
                 ....*....|....
gi 505162042  81 TDEIYIGDYIINVE 94
Cdd:COG1716   81 GDVIRLGKTELRFR 94
FHA cd00060
forkhead associated (FHA) domain superfamily; Forkhead-associated (FHA) domains are small ...
 4-94 1.39e-22

forkhead associated (FHA) domain superfamily; Forkhead-associated (FHA) domains are small phosphopeptide recognition modules mostly found in eubacteria and eukaryotes. It is about 95-120 residues long that fold into an 11-stranded beta-sandwich. FHA domains can mediate the recognition of phosphorylated and non-phosphorylated substrates, as well as protein oligomerization. They specifically recognize threonine phosphorylation (pThr) accompanying activation of protein serine/threonine kinases. FHA domains show diverse ligand specificity. They may recognize the pTXXD motif, the pTXXI/L motif, and TQ clusters (singly and multiply phosphorylated). In eukaryotes, FHA superfamily members include forkhead-type transcription factors, as well as other signaling proteins, such as many regulatory proteins, kinases, phosphatases, motor proteins called kinesins, and metabolic enzymes. Many of them localize to the nucleus, where they participate in establishing or maintaining cell cycle checkpoints, DNA repair, or transcriptional regulation. FHA domains play important roles in human diseases, particularly in relation to DNA damage responses and cancers. In bacteria, FHA domain-containing proteins may participate in injection of viral proteins into host cells, transmembrane transporters, and cell division. FHA domain-containing proteins rarely include more than one copy of the domain. The only exception in eukaryotes is the checkpoint kinase Rad53 from Saccharomyces cerevisiae, which harbors two FHA domains (FHA1 and FHA2) flanking a central kinase domain. The two FHA domains recognize different phosphorylated targets and function independently from one another. In contrast, Mycobacterium tuberculosis ABC transporter Rv1747 contains two FHA domains but only one of them is essential for protein function.


Pssm-ID: 438714 [Multi-domain]  Cd Length: 92  Bit Score: 92.34  E-value: 1.39e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505162042   4 ITLAEKGGGTEQREYHKPEITIGRLPGNDIMLAKGNVSKYHSRIVAKDGKCIIVDMKSTNGTFVNGKKIAAPQVLKPTDE 83
Cdd:cd00060    2 LIVLDGDGGGREFPLTKGVVTIGRSPDCDIVLDDPSVSRRHARIEVDGGGVYLEDLGSTNGTFVNGKRITPPVPLQDGDV 81

                         90
                 ....*....|.
gi 505162042  84 IYIGDYIINVE 94
Cdd:cd00060   82 IRLGDTTFRFE 92
FHA pfam00498
FHA domain; The FHA (Forkhead-associated) domain is a phosphopeptide binding motif.
 23-86 8.78e-13

FHA domain; The FHA (Forkhead-associated) domain is a phosphopeptide binding motif.


Pssm-ID: 459831 [Multi-domain]  Cd Length: 66  Bit Score: 63.36  E-value: 8.78e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 505162042   23 ITIGRLPGNDIMLAKGNVSKYHSRIVAKDG-KCIIVDMKSTNGTFVNGKKI-AAPQVLKPTDEIYI 86
Cdd:pfam00498   1 VTIGRSPDCDIVLDDPSVSRRHAEIRYDGGgRFYLEDLGSTNGTFVNGQRLgPEPVRLKDGDVIRL 66
FHA smart00240
Forkhead associated domain; Found in eukaryotic and prokaryotic proteins. Putative nuclear ...
 23-72 3.80e-09

Forkhead associated domain; Found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain.


Pssm-ID: 214578 [Multi-domain]  Cd Length: 52  Bit Score: 52.57  E-value: 3.80e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 505162042    23 ITIGRLP-GNDIMLAKGNVSKYHSRIVAKDGKCI-IVDMKSTNGTFVNGKKI 72
Cdd:smart00240   1 VTIGRSSeDCDIQLDGPSISRRHAVIVYDGGGRFyLIDLGSTNGTFVNGKRI 52
VI_FHA TIGR03354
type VI secretion system FHA domain protein; Members of this protein family are FHA ...
 4-107 1.69e-07

type VI secretion system FHA domain protein; Members of this protein family are FHA (forkhead-associated) domain-containing proteins that are part of type VI secretion loci in a considerable number of bacteria, most of which are known pathogens. Species include Pseudomonas aeruginosa PAO1, Aeromonas hydrophila, Yersinia pestis, Burkholderia mallei, etc. [Protein fate, Protein and peptide secretion and trafficking, Cellular processes, Pathogenesis]


Pssm-ID: 274537 [Multi-domain]  Cd Length: 396  Bit Score: 53.91  E-value: 1.69e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505162042    4 ITLAEKGGGTEQREY--HKPEITIGRLPGNDIML--AKGNVSKYHSRIVAKDGKCIIVDMkSTNGTFVNGKKI----AAP 75
Cdd:TIGR03354   5 VLNAHQLTPGIAAQKtfGTNGGTIGRSEDCDWVLpdPERHVSGRHARIRYRDGAYLLTDL-STNGVFLNGSGSplgrGNP 83

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 505162042   76 QVLKPTDEIYIGDYIINV---EPLEDAGPAMTRAG 107
Cdd:TIGR03354  84 VRLEQGDRLRLGDYEIRVslgDPLVSRQASESRAD 118
PLN02927 PLN02927
antheraxanthin epoxidase/zeaxanthin epoxidase
 28-87 1.29e-03

antheraxanthin epoxidase/zeaxanthin epoxidase


Pssm-ID: 178515 [Multi-domain]  Cd Length: 668  Bit Score: 41.62  E-value: 1.29e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 505162042  28 LPGNDIMLAKGNVSKYHSRIVAKDGKCIIVDMKSTNGTFVN---GKKIAA----PQVLKPTDEIYIG 87
Cdd:PLN02927 569 FPGMRIVIPSSQVSKMHARVIYKDGAFFLMDLRSEHGTYVTdneGRRYRAtpnfPARFRSSDIIEFG 635
 
Name Accession Description Interval E-value
CpaF COG4962
Pilus assembly protein, ATPase of CpaF family [Intracellular trafficking, secretion, and ...
 196-583 0e+00

Pilus assembly protein, ATPase of CpaF family [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 443988 [Multi-domain]  Cd Length: 386  Bit Score: 552.08  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505162042 196 DRLGDDELWRRTEKAIRDIIdqmEADGELPEDVDREELLTDVINEALGLGPLEAFLASDEISEIMVNHANQIYIERKGKL 275
Cdd:COG4962   11 RRLDREELREEVRAAVAEAL---RAEGLVLSDAEREALARAVLDELFGLGPLEPLLDDPDVTDIMVNGPDEVFVERGGRL 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505162042 276 TLSEKTFSSNQAVLGVIERIVAPIGRRIDESSPLVDARLKDGSRVNAIIPPLALKGPCITIRKFKKDSLKIQDLIKYKTL 355
Cdd:COG4962   88 ERTDVRFDSEEELRRLIERIAARVGRRLDESSPIVDARLPDGSRVNAVIPPVARDGPSLSIRKFRKRPLTLEDLVALGSL 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505162042 356 TAQMAEFLEMCVKARRNIVIsggtgsgktttLNIISAFIPDSERIVTVEDAAELQLPQDHWVQLESRPPNLEGKGAITIR 435
Cdd:COG4962  168 TPEMAEFLRAAVRARLNILVsggtgsgkttlLNALSGFIPPDERIVTIEDAAELQLQHPHVVRLETRPPNVEGAGEVTLR 247

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505162042 436 DLVKNCLRMRPDRIVVGECRSGETLDMLQAMNTGHDGSLTTLHANTPRDAIARLETMVLMSGMELPVKAIREQIASAVHM 515
Cdd:COG4962  248 DLVRNALRMRPDRIIVGEVRGAEALDMLQAMNTGHDGSMSTLHANSARDALARLETLALMAGENLPREAVRRQIASAIDL 327

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 505162042 516 IVQQTRFSDGTRKICFVTEVSGMEVDIVTLQDIFYYKQDGFTEDHKVRgrfvasgfvPKFYDELQRKG 583
Cdd:COG4962  328 VVHLERLRDGRRRVTEIAEVTGMEGGRVVLQPIFRFDPGGLDAAGGVR---------PRFLERLEAAG 386
heli_sec_ATPase TIGR03819
helicase/secretion neighborhood ATPase; Members of this protein family comprise a distinct ...
 210-529 3.88e-89

helicase/secretion neighborhood ATPase; Members of this protein family comprise a distinct clade of putative ATPase associated with an integral membrane complex likely to act in pilus formation, secretion, or conjugal transfer. The association of most members with a nearby gene for a DEAH-box helicase suggests a role in conjugal transfer.


Pssm-ID: 200328  Cd Length: 340  Bit Score: 279.22  E-value: 3.88e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505162042  210 AIRDIIDQMEADGELPEDVdrEELLTDVInealGLGPLEAFLASDEISEIMVNHANQIYIERKGKLTLSEKTFSSNQAVL 289
Cdd:TIGR03819  24 AVRAEAGRVLGDAEVLAAA--RALRRDLV----GAGPLEPLLADPGVTDVLVNGPDEVWVDRGRGLERTDVRFPDEAAVR 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505162042  290 GVIERIVAPIGRRIDESSPLVDARLKDGSRVNAIIPPLALKGPCITIRKFKKDSLKIQDLIKYKTLTAQMAEFLEMCVKA 369
Cdd:TIGR03819  98 RLAQRLAAAAGRRLDDAQPWVDARLPDGTRLHAVLPPVATDGTCLSLRVPRRRTFTLDELVAAGTIPPGVARLLRALVAA 177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505162042  370 RRNIVISGGTGSGKTTTLNIISAFIPDSERIVTVEDAAELQLPQDHWVQLESRPPNLEGKGAITIRDLVKNCLRMRPDRI 449
Cdd:TIGR03819 178 RLAFLVSGGTGSGKTTLLSALLALVPPDERIVLVEDAAELRPDHPHVVRLEARPANVEGAGAVTLTDLVRQALRMRPDRI 257

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505162042  450 VVGECRSGETLDMLQAMNTGHDGSLTTLHANTPRDAIARLETMVLMSGMELPvkAIREQIASAVHMIVQQTRFSDGTRKI 529
Cdd:TIGR03819 258 VVGEVRGAEVVDLLAALNTGHDGGAGTLHANSPADVPARLEALGALAGLDRA--ALHSQLAAALDVVLHVRRTPRGRRRV 335
VirB11-like_ATPase cd01130
Type IV secretory pathway component VirB11-like; Type IV secretory pathway component VirB11, ...
 359-535 2.75e-73

Type IV secretory pathway component VirB11-like; Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir (virulence) proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the bacterial Ti (tumor-inducing)-plasmid into plant cells. The pilus is a fibrous cell surface organelle, which mediates adhesion between bacteria during conjugative transfer or between bacteria and host eukaryotic cells during infection. VirB11-related ATPases include Sulfolobus acidocaldarius FlaI, which plays key roles in archaellum (archaeal flagellum) assembly and motility functions, and the pilus assembly proteins CpaF/TadA and TrbB. This alignment contains the C-terminal domain, which is the ATPase.


Pssm-ID: 410874 [Multi-domain]  Cd Length: 177  Bit Score: 232.05  E-value: 2.75e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505162042 359 MAEFLEMCVKARRNIVISGGTGSGKTTTLNIISAFIPDSERIVTVEDAAELQLPQDHWVQLESRPPNLEgKGAITIRDLV 438
Cdd:cd01130    1 MAAFLRLAVRARKNILISGGTGSGKTTLLNALLSFIPPDERIVTIEDTRELQLPHPNVVHLLTRPGGGE-KGEVTMADLL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505162042 439 KNCLRMRPDRIVVGECRSGETLDMLQAMNTGHDGSLTTLHANTPRDAIARLETMVLMSGMELPVKAIREQIASAVHMIVQ 518
Cdd:cd01130   80 KAALRMRPDRIIVGEVRGGEAYDMLQAMNTGHPGSITTIHANSAEDAIDRLATLVLEAGVNLDEEALRRLIASAIDVIVH 159

                        170
                 ....*....|....*..
gi 505162042 519 QTRFSDGTRKICFVTEV 535
Cdd:cd01130  160 VKRLGDGVRRVTEIYEV 176
VirB11 COG0630
Type IV secretory pathway ATPase VirB11/Archaellum biosynthesis ATPase ArlI/FlaI [Cell ...
 171-535 1.39e-65

Type IV secretory pathway ATPase VirB11/Archaellum biosynthesis ATPase ArlI/FlaI [Cell motility, Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440395 [Multi-domain]  Cd Length: 462  Bit Score: 221.49  E-value: 1.39e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505162042 171 ERYTRLQKEIHDRLIEYLDLRRMDMDRLGDDELWRRTEKAIRDIIDQMEADGELPEDVDREELLTDVINEALGLGPLEAF 250
Cdd:COG0630   88 VEEPPDSEEEEELLEEEERLLEELLLLEEEDALEDLEVLLLRELDSLLKDYKIKVSEERLEKLLYYLLRDFVGYGKLDPL 167

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505162042 251 LASDEISEIMVNHAN-QIYIE--RKGKLTLSEkTFSSNQAVLGVIERIVAPIGRRIDESSPLVDARLKDGSRVNAIIPP- 326
Cdd:COG0630  168 MRDPNIEDISCNGVGiPVYVYhrDYERIPTNI-VFESEEELDNFVVKLAQRSGKHISVARPIVDATLPDGSRIALTLGPe 246

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505162042 327 LALKGPCITIRKFKKDSLKIQDLIKYKTLTAQMAEFLEMCVKARRNIVISGGTGSGKTTTLNIISAFIPDSERIVTVEDA 406
Cdd:COG0630  247 VSRRGSSFTIRKFREVPLTPIDLIEWGTLSPELAAYLWLLLENGKSVLVAGGTASGKTTLLNALLSFIPPDAKIVTIEDT 326

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505162042 407 AELQLPQDHWVQLESRPPNLEGKGAITIRDLVKNCLRMRPDRIVVGECRSGETLDMLQAMNTGHdGSLTTLHANTPRDAI 486
Cdd:COG0630  327 RELNLPHENWISLVTRESFGGEEGDVTMFDLLKAALRQRPDYIVVGEVRGEEAYTLFQAMATGH-GVLSTFHADSVESAI 405

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*....
gi 505162042 487 ARLETmvlmSGMELPvkaiREQIaSAVHMIVQQTRFSDGTRKICFVTEV 535
Cdd:COG0630  406 NRLTS----PPINVP----RTLL-QALDLVVFQKRVRVGGKRVRRVTSI 445
T2SSE pfam00437
Type II/IV secretion system protein; This family contains components of both the Type II ...
 243-519 1.33e-60

Type II/IV secretion system protein; This family contains components of both the Type II protein secretion system (T2SS), including Type 4 pilus (T4P), and Type IV protein secretion system (T4SS) from Gram-negative bacteria. VirB11 ATPase is a subunit of the Agrobacterium tumefaciens transfer DNA (T-DNA) transfer system, a type IV secretion pathway required for delivery of T-DNA and effector proteins to plant cells during infection. The cytoplasmic T2S E ATPase is a Zn-containing protein thought to provide the mechanical force for the secretion process. T2S-E contains Walker A and B motifs, that are essential for secretion and ATPase activity. ATPase PulE and XcpR from Klebsiella oxytoca and Pseudomonas aeruginosa respectively are required for protein secretion via the T2SS. ATPase PilB is required for T4P extension.


Pssm-ID: 425681 [Multi-domain]  Cd Length: 269  Bit Score: 202.13  E-value: 1.33e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505162042  243 GLGPLEAFLASdeISEIMVNHANQIYI--ERKGKlTLSEKTFSSNQAVLGVIERIVAPIGRRIDESSPLVDARLK----- 315
Cdd:pfam00437   1 NLIPLEALDEG--ASDIHVEPPERIVWirFRVDG-VLREIPFPDADALARLISRIKVMARLDISERRPPQDGRLPlrigg 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505162042  316 DGSRVNAIIPPLALkGPCITIRKFKKDS--LKIQDLIKYKTLTAQMAEFLEmcvKARRNIVISGGTGSGKTTTLNIISAF 393
Cdd:pfam00437  78 KGVRVRVSTLPTAG-GEKLVIRLLDPSNvaLSLDELGMTGAQDEALLEFLR---QPRGNILVTGPTGSGKTTTLYAALGE 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505162042  394 IP-DSERIVTVEDAAELQLPQDHWVQLESRppnlegkGAITIRDLVKNCLRMRPDRIVVGECRSGETLDM-LQAMNTGHD 471
Cdd:pfam00437 154 LNtRDENIVTVEDPVEIQLEGINQVQLNAR-------AGVTFADLLRAILRQDPDRIMVGEIRDLETAEIaLQAANTGHL 226

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 505162042  472 GsLTTLHANTPRDAIARLETMVlmsgmeLPVKAIREQIASAvhmIVQQ 519
Cdd:pfam00437 227 V-LSTLHTNSAAGALTRLQDMG------VPPFELASSLLLV---IAQR 264
VirB11 TIGR02788
P-type DNA transfer ATPase VirB11; The VirB11 protein is found in the vir locus of ...
 250-532 1.70e-56

P-type DNA transfer ATPase VirB11; The VirB11 protein is found in the vir locus of Agrobacterium Ti plasmids where it is involved in the type IV secretion system for DNA transfer. VirB11 is believed to be an ATPase. VirB11 is a homolog of the P-like conjugation system TrbB protein and the Flp pilus sytem protein TadA.


Pssm-ID: 274301  Cd Length: 308  Bit Score: 192.57  E-value: 1.70e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505162042  250 FLASDEISEIMVNHANQIYIERKGKLTLSEKTFSSNQAVLGVIERIVAPIGRRIDESSPLVDARLKDGSRVNAIIPPLAL 329
Cdd:TIGR02788   1 FLDDEDVTEICINRPGEVWVEGPGGWQRFDVPDLTFSHLMRLARAIASFSKQSISEENPILSATLPGGERVQIVIPPACE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505162042  330 KGPC-ITIRKFKKDSLKIQDLIK---YKTLTAQ-------------------MAEFLEMCVKARRNIVISGGTGSGKTTT 386
Cdd:TIGR02788  81 NDTVsITIRKPSLVDFSLDDYEEkgfFDTVRAQsgtlsdndeqllelldagdIKEFLRLAIASRKNIIISGGTGSGKTTF 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505162042  387 LNIISAFIPDSERIVTVEDAAELQLPQDHWVQLESrPPNLEGKGAITIRDLVKNCLRMRPDRIVVGECRSGETLDMLQAM 466
Cdd:TIGR02788 161 LKSLVDEIPKDERIITIEDTREIFLPHPNYVHLFY-SKGGQGLAKVTPKDLLQSCLRMRPDRIILGELRGDEAFDFIRAV 239

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 505162042  467 NTGHDGSLTTLHANTPRDAIARLETMVLMS--GMELPVKAIREQIASAVHMIVQQTRFSDGtRKICFV 532
Cdd:TIGR02788 240 NTGHPGSITTLHAGSPEEAFEQLALMVKSSqaGLGLDFAYIVKLVREVIDIVVQINRRGGG-RKITEV 306
TrbB_P TIGR02782
P-type conjugative transfer ATPase TrbB; The TrbB protein is found in the trb locus of ...
 244-537 9.61e-47

P-type conjugative transfer ATPase TrbB; The TrbB protein is found in the trb locus of Agrobacterium Ti plasmids where it is involved in the type IV secretion system for plasmid conjugative transfer. TrbB is a homolog of the vir system VirB11 ATPase, and the Flp pilus sytem ATPase TadA. [Cellular processes, Conjugation]


Pssm-ID: 274297  Cd Length: 299  Bit Score: 166.07  E-value: 9.61e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505162042  244 LGP-LEAFLASDEISEIMVNHANQIYIERKGKlTLSEKTFSSNQAVLGVIERIVAPIGRRIDESSPLVDARLK-DGSRVN 321
Cdd:TIGR02782   6 LGPeIAAALDDPGVVEIMLNPDGRLWVERLGS-GMSPLGEMSPADAQRIIGLVADYLGTEVDRDKPIVEGELPlDGSRFE 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505162042  322 AIIPPLaLKGPCITIRKFKKDSLKIQDLIKYKTLTAQMAEFLEMCVKARRNIVIS----GGTGSGKTTTLNIISAFIPDs 397
Cdd:TIGR02782  85 GLIPPV-VAAPSFAIRKKAVAVFTLDDYVEAGIMTAAQRDVLREAVLARKNILVVggtgSGKTTLANALLAEIAKNDPT- 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505162042  398 ERIVTVEDAAELQLPQDHWVQLESRPpnlegkGAITIRDLVKNCLRMRPDRIVVGECRSGETLDMLQAMNTGHDGSLTTL 477
Cdd:TIGR02782 163 DRVVIIEDTRELQCAAPNVVQLRTSD------DAISMTRLLKATLRLRPDRIIVGEVRGGEALDLLKAWNTGHPGGIATI 236

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 505162042  478 HANTPRDAIARLETMVLMSGmelpVKAIREQIASAVHMIVQQTRFSDGtRKICFVTEVSG 537
Cdd:TIGR02782 237 HANNAKAALDRLEQLIQEVS----VTPMQTLIAEAVDLVIFIARTPAG-RRVQEIAKVKG 291
PRK13900 PRK13900
type IV secretion system ATPase VirB11; Provisional
 244-535 2.76e-46

type IV secretion system ATPase VirB11; Provisional


Pssm-ID: 184381  Cd Length: 332  Bit Score: 166.09  E-value: 2.76e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505162042 244 LGPLEAFLASDEISEIMVNHANQIYIERKGKLtLSEKTFSSNQAVLGVIERIVA-PIGRRIDESSPLVDARLKDGSRVNA 322
Cdd:PRK13900  12 LEPLKNIFAEDGVNEISINKPGEVWVEKKGDI-RCEQIPELDLSHLKALGRLVAqATEQKISEEKPLLSATLPNGYRIQI 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505162042 323 IIPPLALKGPCI-TIRK-------------------FKKDSLKIQDLIKYKTLTAQ--MAEFLEMCVKARRNIVISGGTG 380
Cdd:PRK13900  91 VFPPACEIGQIVySIRKpsgmqltlddyekmgafdeTATESLVDEDDVILNELLAEkkIKEFLEHAVISKKNIIISGGTS 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505162042 381 SGKTTTLNIISAFIPDSERIVTVEDAAELQLPqDH--WVQLESRPPNlEGKGAITIRDLVKNCLRMRPDRIVVGECRSGE 458
Cdd:PRK13900 171 TGKTTFTNAALREIPAIERLITVEDAREIVLS-NHpnRVHLLASKGG-QGRAKVTTQDLIEACLRLRPDRIIVGELRGAE 248

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 505162042 459 TLDMLQAMNTGHDGSLTTLHANTPRDAIARLETMVLMSGMELPVKAIREQIASAVHMIVQQTRFSDGTRkicFVTEV 535
Cdd:PRK13900 249 AFSFLRAINTGHPGSISTLHADSPAMAIEQLKLMVMQAGLGMPPDQIKKYILNVVDIVVQLKRGSGGKR---YVSEI 322
PRK13894 PRK13894
conjugal transfer ATPase TrbB; Provisional
 244-537 1.32e-40

conjugal transfer ATPase TrbB; Provisional


Pssm-ID: 184377  Cd Length: 319  Bit Score: 149.89  E-value: 1.32e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505162042 244 LGP-LEAFLASDEISEIMVNHANQIYIERKGKLTLSEKTFSSNQAVlGVIERIVAPIGRRIDESSPLVDARLK-DGSRVN 321
Cdd:PRK13894  22 MGPeLLAALNDPKTVEIMLNADGKLWQERLGEPMRCIGTLRVAQAQ-AIIETIAGYHGKEVTRSKPILEGELPlDGSRFA 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505162042 322 AIIPPLAlKGPCITIRKFKKDSLKIQDLIKYKTLTAQMAEFLEMCVKARRNIVISGGTGSGKTTTLN-IISAFIPD--SE 398
Cdd:PRK13894 101 GQLPPVV-PAPTFAIRKKAVAIFTLDQYVERGIMTAAQREAIIAAVRAHRNILVIGGTGSGKTTLVNaIINEMVIQdpTE 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505162042 399 RIVTVEDAAELQLPQDHWVQLESrppNLEgkgaITIRDLVKNCLRMRPDRIVVGECRSGETLDMLQAMNTGHDGSLTTLH 478
Cdd:PRK13894 180 RVFIIEDTGEIQCAAENYVQYHT---SID----VNMTALLKTTLRMRPDRILVGEVRGPEALDLLMAWNTGHEGGAATLH 252

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 505162042 479 ANTPRDAIARLETMVLMSgmELPVKAIREQIASAVHMIVQQTRfSDGTRKICFVTEVSG 537
Cdd:PRK13894 253 ANNAKAGLDRLKSLISMH--PDAPKPIEPLIGEAVHVVVHIAR-TPGGRRIQEILEVSG 308
PRK13833 PRK13833
conjugal transfer protein TrbB; Provisional
 238-527 2.08e-32

conjugal transfer protein TrbB; Provisional


Pssm-ID: 172360 [Multi-domain]  Cd Length: 323  Bit Score: 127.22  E-value: 2.08e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505162042 238 INEALGlGPLEAFLASDEISEIMVNHANQIYIERKGKLTLSEKTFSSNQAVLgVIERIVAPIGRRIDESSPLVDARLK-D 316
Cdd:PRK13833  14 LQDALG-DQLCVALDDATVVEIMLNPDGKLFIERLGHGVAPAGEMSAAAAEV-VIGSVAHALQSEADDERPIISGELPiG 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505162042 317 GSRVNAIIPPLAlKGPCITIRKFKKDSLKIQDLIKYKTLTAQMAEFLEMCVKARRNIVISGGTGSGKTTTLNIISAFIPD 396
Cdd:PRK13833  92 GHRFEGLLPPVV-SGPAFTIRRRASRLIPLDDYVTSKIMTEAQASVIRSAIDSRLNIVISGGTGSGKTTLANAVIAEIVA 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505162042 397 S---ERIVTVEDAAELQLPQDHWVQLESrppnlegKGAITIRDLVKNCLRMRPDRIVVGECRSGETLDMLQAMNTGHDGS 473
Cdd:PRK13833 171 SapeDRLVILEDTAEIQCAAENAVALHT-------SDTVDMARLLKSTMRLRPDRIIVGEVRDGAALTLLKAWNTGHPGG 243

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 505162042 474 LTTLHANTPRDAIARLETMVlmsgMELPVKAIREQIASAVHMIVQQTRFSDGTR 527
Cdd:PRK13833 244 VTTIHSNTAMSALRRLEQLT----AEASQQPMQEVIGEAVDLIVSIERTGKGRR 293
FHA COG1716
Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms];
1-94 2.71e-24

Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms];


Pssm-ID: 441322 [Multi-domain]  Cd Length: 96  Bit Score: 97.34  E-value: 2.71e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505162042   1 MFLITLAEKGGGTEQREYHKPEITIGRLPGNDIMLAKGNVSKYHSRIVAKDGKCIIVDMKSTNGTFVNGKKIAAPQVLKP 80
Cdd:COG1716    1 MARLVVLEGPLAGRRFPLDGGPLTIGRAPDNDIVLDDPTVSRRHARIRRDGGGWVLEDLGSTNGTFVNGQRVTEPAPLRD 80

                         90
                 ....*....|....
gi 505162042  81 TDEIYIGDYIINVE 94
Cdd:COG1716   81 GDVIRLGKTELRFR 94
FHA cd00060
forkhead associated (FHA) domain superfamily; Forkhead-associated (FHA) domains are small ...
 4-94 1.39e-22

forkhead associated (FHA) domain superfamily; Forkhead-associated (FHA) domains are small phosphopeptide recognition modules mostly found in eubacteria and eukaryotes. It is about 95-120 residues long that fold into an 11-stranded beta-sandwich. FHA domains can mediate the recognition of phosphorylated and non-phosphorylated substrates, as well as protein oligomerization. They specifically recognize threonine phosphorylation (pThr) accompanying activation of protein serine/threonine kinases. FHA domains show diverse ligand specificity. They may recognize the pTXXD motif, the pTXXI/L motif, and TQ clusters (singly and multiply phosphorylated). In eukaryotes, FHA superfamily members include forkhead-type transcription factors, as well as other signaling proteins, such as many regulatory proteins, kinases, phosphatases, motor proteins called kinesins, and metabolic enzymes. Many of them localize to the nucleus, where they participate in establishing or maintaining cell cycle checkpoints, DNA repair, or transcriptional regulation. FHA domains play important roles in human diseases, particularly in relation to DNA damage responses and cancers. In bacteria, FHA domain-containing proteins may participate in injection of viral proteins into host cells, transmembrane transporters, and cell division. FHA domain-containing proteins rarely include more than one copy of the domain. The only exception in eukaryotes is the checkpoint kinase Rad53 from Saccharomyces cerevisiae, which harbors two FHA domains (FHA1 and FHA2) flanking a central kinase domain. The two FHA domains recognize different phosphorylated targets and function independently from one another. In contrast, Mycobacterium tuberculosis ABC transporter Rv1747 contains two FHA domains but only one of them is essential for protein function.


Pssm-ID: 438714 [Multi-domain]  Cd Length: 92  Bit Score: 92.34  E-value: 1.39e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505162042   4 ITLAEKGGGTEQREYHKPEITIGRLPGNDIMLAKGNVSKYHSRIVAKDGKCIIVDMKSTNGTFVNGKKIAAPQVLKPTDE 83
Cdd:cd00060    2 LIVLDGDGGGREFPLTKGVVTIGRSPDCDIVLDDPSVSRRHARIEVDGGGVYLEDLGSTNGTFVNGKRITPPVPLQDGDV 81

                         90
                 ....*....|.
gi 505162042  84 IYIGDYIINVE 94
Cdd:cd00060   82 IRLGDTTFRFE 92
PRK13851 PRK13851
type IV secretion system protein VirB11; Provisional
 244-517 4.79e-22

type IV secretion system protein VirB11; Provisional


Pssm-ID: 172375  Cd Length: 344  Bit Score: 97.66  E-value: 4.79e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505162042 244 LGPLEAFLASDEISEIMVNHANQIYIERKGKLTLSEKTFSSNQavlgvIERIVAPIG--RRID--ESSPLVDARLKDGSR 319
Cdd:PRK13851  11 LKPVLEWLDDPRTEEVAINRPGEAFVRQAGVFTKFPLPLSYDD-----LEDIAILAGalRKQDvgPRNPLCATELPGGER 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505162042 320 VNAIIPPLALKGPC-ITIR------------------------KFKKDSLKIQD--LIKYKTlTAQMAEFLEMCVKARRN 372
Cdd:PRK13851  86 LQICLPPTVPSGTVsLTIRrpssrvselkevssrydasrwnqwQERRKRRDQLDeaILRHYD-NGDLEAFLHACVVGRLT 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505162042 373 IVISGGTGSGKTTTLNIISAFIPDSERIVTVEDAAELQLPQDHWVQLeSRPPNLEGKGAITIRDLVKNCLRMRPDRIVVG 452
Cdd:PRK13851 165 MLLCGPTGSGKTTMSKTLISAIPPQERLITIEDTLELVIPHENHVRL-LYSKNGAGLGAVTAEHLLQASLRMRPDRILLG 243

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 505162042 453 ECRSGETLDMLQAMNTGHDGSLTTLHANTPRDAIARLETMVLMS--GMELPVKAIREQIASAVHMIV 517
Cdd:PRK13851 244 EMRDDAAWAYLSEVVSGHPGSISTIHGANPVQGFKKLFSLVKSSaqGASLEDRTLIDMLATAIDVIV 310
type_II_IV_secretion_ATPases cd19477
type II/type IV hexameric secretion ATPases; RecA-like NTPases. This family includes the NTP ...
 367-519 3.49e-19

type II/type IV hexameric secretion ATPases; RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410885 [Multi-domain]  Cd Length: 168  Bit Score: 85.14  E-value: 3.49e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505162042 367 VKARRNIVISGGTGSGKTTTLNIISAFIPDSERIVTVEDAAELQLPQ-DHWVQLESRPpnlegkgAITIRDLVKNCLRMR 445
Cdd:cd19477    7 IAIGKNVIVCGGTGSGKTTYIKSILEFIPKEERIISIEDTEEIVFKHhKNYTQLFFGG-------NITSADCLKSCLRQR 79

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 505162042 446 PDRIVVGECRSGETLDMLQAMNTGHDGSLTTLHANTPRDAIARLETMVLMSGMELPVK--AIREQIASAVHMIVQQ 519
Cdd:cd19477   80 PDRIILGELRSSEAYDFYNVLCSGHKGTLTTLHAGSSEEAFIRLAN*SSSNSAARNIKfeSLIEGFKDLIDGIVHI 155
PulE-GspE-like cd01129
PulE-GspE family; PulE and General secretory pathway protein GspE are ATPases of the type II ...
 399-519 3.05e-15

PulE-GspE family; PulE and General secretory pathway protein GspE are ATPases of the type II secretory pathway, the main terminal branch of the general secretory pathway (GSP). PulE is a cytoplasmic protein of the GSP, which contains an ATP binding site and a tetracysteine motif. This subgroup also includes PilB, a type IV pilus assembly ATPase, DotB, an ATPase of the type IVb secretion system, also known as the dot/icm system, Escherichia coli IncI plasmid-encoded conjugative transfer ATPase TraJ, and HofB.


Pssm-ID: 410873 [Multi-domain]  Cd Length: 159  Bit Score: 73.29  E-value: 3.05e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505162042 399 RIVTVEDAAELQLPQdhWVQLESRPpnlegKGAITIRDLVKNCLRMRPDRIVVGECRSGETLDM-LQAMNTGHDgSLTTL 477
Cdd:cd01129   41 NIITIEDPVEYQIPG--INQSQVNE-----KIGLTFADALRAILRQDPDIIMVGEIRDAETAEIaIRAALTGHL-VLSTL 112

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 505162042 478 HANTPRDAIARLETMvlmsGMElpvkaiREQIASAVHMIVQQ 519
Cdd:cd01129  113 HTNDALGAITRLLDM----GIE------PFLLASALRGVIAQ 144
FHA_FhaB-like cd22693
forkhead associated (FHA) domain found in Mycobacterium tuberculosis FHA domain-containing ...
 20-93 5.14e-14

forkhead associated (FHA) domain found in Mycobacterium tuberculosis FHA domain-containing protein FhaB and similar proteins; FhaB, also called FtsZ-interacting protein A (FipA), is a putative virulence factor involved in regulating cell shape. It can interact with polyketide-associated protein PapA5, a putative membrane protein involved in the biosynthesis of virulence enhancing lipids. FhaB regulates growth and cell division. It is probably required for divisomal protein assembly under oxidative stress. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438745 [Multi-domain]  Cd Length: 91  Bit Score: 67.71  E-value: 5.14e-14
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 505162042  20 KPEITIGRLPGNDIMLAKGNVSKYHSRIVAKDGKCIIVDMKSTNGTFVNGKKIAAPQVLKPTDEIYIGDYIINV 93
Cdd:cd22693   17 KSGITIGRADDNDLVLSDDFVSSRHARIYLQGSSWYLEDLGSTNGTFVNGNRVTQPVVVQPGDTIRIGATVFEV 90
FHA_Ki67 cd22673
forkhead associated (FHA) domain found in proliferation marker protein Ki-67 and similar ...
 9-89 6.21e-14

forkhead associated (FHA) domain found in proliferation marker protein Ki-67 and similar proteins; Ki-67, also called antigen identified by monoclonal antibody Ki-67, antigen KI-67, or antigen Ki67, acts as a biological surfactant to disperse mitotic chromosomes. It is required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly. Ki-67 binds DNA with a preference for supercoiled DNA and AT-rich DNA. It may also play a role in chromatin organization. Ki-67 contains an FHA domain at its N-terminus. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438725 [Multi-domain]  Cd Length: 95  Bit Score: 67.62  E-value: 6.21e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505162042   9 KGGGTEQREY--HKPEITIGRLPGNDIMLAKGNVSKYHSRI-VAKDGKCIIVDMKSTNGTFVNGKKIAAPQVLKPTDEIY 85
Cdd:cd22673    7 KKDGTDGSRFplTKKSCTFGRDLSCDIRIQLPGVSREHCRIeVDENGKAYLENLSTTNPTLVNGKAIEKSAELKDGDVIT 86


                 ....
gi 505162042  86 IGDY 89
Cdd:cd22673   87 IGGR 90
FHA_DgcB-like cd22682
forkhead associated (FHA) domain found in Bdellovibrio bacteriovorus GGDEF domain protein DgcB ...
 3-94 1.82e-13

forkhead associated (FHA) domain found in Bdellovibrio bacteriovorus GGDEF domain protein DgcB and similar proteins; DgcB is a GGDEF enzyme that produces cyclic-di-GMP in response to an unknown stimulus. It appends the C-terminal GGDEF enzymatic domain with an N-terminal forkhead-associated (FHA) domain that acts as a consensus phosphopeptide sensor. The GGDEF and sensory FHA domains form an asymmetrical dimer.


Pssm-ID: 438734 [Multi-domain]  Cd Length: 96  Bit Score: 66.40  E-value: 1.82e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505162042   3 LITLAEKGGGtEQREYHKPEITIGRLPGNDIMLAKGNVSKYHSRIVAKDGKCIIVDMKSTNGTFVNGKKIAAPQV--LKP 80
Cdd:cd22682    3 LMIIGPPGVG-KQFPITESTIVIGRSVESQVQIDDDSVSRYHAKLAVNPSAVSIIDLGSTNGTIVNGKKIPKLAScdLQN 81

                         90
                 ....*....|....
gi 505162042  81 TDEIYIGDYIINVE 94
Cdd:cd22682   82 GDQIKIGNTIFKFH 95
FHA_EspA-like cd22698
forkhead associated (FHA) domain found in Myxococcus xanthus EspA and similar proteins; EspA ...
 17-90 6.39e-13

forkhead associated (FHA) domain found in Myxococcus xanthus EspA and similar proteins; EspA is a histidine protein kinase with a fork head-associated (FHA) domain at the N-terminus and a receiver domain at the C-terminus. It functions as an inhibitor of sporulation during early fruiting body development while cells are aggregating into raised mounds. EspA is part of a two-component signal transduction system that regulates the timing of sporulation initiation. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438750 [Multi-domain]  Cd Length: 93  Bit Score: 64.74  E-value: 6.39e-13
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 505162042  17 EYHKPEITIGRLPGNDIMLAKGNVSKYHSRIVAKDGKCIIVDMKSTNGTFVNGKKIAAPQvLKPTDEIYIGDYI 90
Cdd:cd22698   17 ELDQDEFTIGRSSNNDIRLNDHSVSRHHARIVRQGDKCNLTDLGSTNGTFLNGIRVGTHE-LKHGDRIQLGETI 89
FHA pfam00498
FHA domain; The FHA (Forkhead-associated) domain is a phosphopeptide binding motif.
 23-86 8.78e-13

FHA domain; The FHA (Forkhead-associated) domain is a phosphopeptide binding motif.


Pssm-ID: 459831 [Multi-domain]  Cd Length: 66  Bit Score: 63.36  E-value: 8.78e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 505162042   23 ITIGRLPGNDIMLAKGNVSKYHSRIVAKDG-KCIIVDMKSTNGTFVNGKKI-AAPQVLKPTDEIYI 86
Cdd:pfam00498   1 VTIGRSPDCDIVLDDPSVSRRHAEIRYDGGgRFYLEDLGSTNGTFVNGQRLgPEPVRLKDGDVIRL 66
FHA_MDC1 cd22665
forkhead associated (FHA) domain found in mediator of DNA damage checkpoint protein 1 (MDC1) ...
 22-89 1.41e-12

forkhead associated (FHA) domain found in mediator of DNA damage checkpoint protein 1 (MDC1) and similar proteins; MDC1, also called nuclear factor with BRCT domains 1 (NFBD1), is a nuclear chromatin-associated protein that is required for checkpoint mediated cell cycle arrest in response to DNA damage within both the S and G2/M phases of the cell cycle. It directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks. MDC1 contains a forkhead-associated (FHA) domain and two BRCT domains, as well as an internal 41-amino acid repeat sequence. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438717 [Multi-domain]  Cd Length: 97  Bit Score: 63.79  E-value: 1.41e-12
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 505162042  22 EITIGRLPGNDIMLAKGNVSKYHSRIVAKDGKCIIVDMKSTNGTFVNGKKIAAPQV---LKPTDEIYIGDY 89
Cdd:cd22665   22 ENVIGRDPSCSVVLPDKSVSKQHACIEVDGGTHLIEDLGSTNGTRIGNKVRLKPNVryeLIDGDLLLFGDV 92
COG3456 COG3456
Predicted component of the type VI protein secretion system, contains a FHA domain [Signal ...
 19-94 6.09e-12

Predicted component of the type VI protein secretion system, contains a FHA domain [Signal transduction mechanisms, Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 442679 [Multi-domain]  Cd Length: 402  Bit Score: 67.86  E-value: 6.09e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505162042  19 HKPEITIGRLPGNDIMLA--KGNVSKYHSRIVAKDGKCIIVDMkSTNGTFVNGKKIAAPQ----VLKPTDEIYIGDYIIN 92
Cdd:COG3456   24 GRGGGTIGRSADCDWVLPdpDRSVSRRHAEIRFRDGAFCLTDL-STNGTFLNGSDHPLGPgrpvRLRDGDRLRIGDYEIR 102


                 ..
gi 505162042  93 VE 94
Cdd:COG3456  103 VE 104
FHA_Rv1747-like_rpt2 cd22737
second forkhead associated (FHA) domain found in Mycobacterium tuberculosis ABC transporter ...
 1-94 1.43e-11

second forkhead associated (FHA) domain found in Mycobacterium tuberculosis ABC transporter ATP-binding/permease protein Rv1747 and similar proteins; Rv1747 is a putative ATP-binding cassette (ABC) transporter involved in the translocation of an unknown substrate across the membrane. It is required for normal virulent infection by M. tuberculosis. Rv1747 has a cytoplasmic regulatory module consisting of two pThr-interacting forkhead-associated (FHA) domains connected by a conformationally disordered linker with two phospho-acceptor threonines (pThr). Recruitment and phosphorylation of Rv1747 depend on the interaction between its two non-redundant FHA domains and the autophosphorylated form of serine/threonine protein kinase PknF. This model corresponds to the second FHA domain, which has a circularly permuted FHA domain fold with a conserved pThr-binding interface.


Pssm-ID: 439356 [Multi-domain]  Cd Length: 93  Bit Score: 60.97  E-value: 1.43e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505162042   1 MFLITLAekGGGTEQREYHKPEITIGRLPGNDIMLAKGNVSKYHSRIVAKDGKCIIVDMKSTNGTFVNGKKIAApQVLKP 80
Cdd:cd22737    3 MMKITRP--DGDTLTFELPPQAVRIGRASDNDIVIPEGSVSRHHATLVPTPGGTQIRDLRSTNGTFVNGLRVDA-ALLHD 79

                         90
                 ....*....|....
gi 505162042  81 TDEIYIGDYIINVE 94
Cdd:cd22737   80 GDVVTIGDIDFVFE 93
FHA_ArnA-like cd22680
forkhead associated (FHA) domain found in Sulfolobus Acidocaldarius FHA domain-containing ...
 22-91 1.52e-11

forkhead associated (FHA) domain found in Sulfolobus Acidocaldarius FHA domain-containing protein ArnA and similar proteins; ArnA is an FHA domain-containing protein from Sulfolobus acidocaldarius that was shown to strongly interact with ArnB, a von Willebrand domain-containing protein. They act synergistically and negatively to modulate motility. ArnA is involved in regulating archaella expression in S. acidocaldarius. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438732 [Multi-domain]  Cd Length: 96  Bit Score: 60.82  E-value: 1.52e-11
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 505162042  22 EITIGRLPGNDIMLAKGNVSKYHSRIVAKDGKCIIVDMKSTNGTFVN-GKKIAAPQVLKPTDEIYIGDYII 91
Cdd:cd22680   22 SVSIGRDPENVIVIPDPFVSRNHARITVDSNEIYIEDLGSTNGTFVNdFKRIKGPAKLHPNDIIKLGRTTV 92
FHA_EmbR-like cd22669
forkhead associated (FHA) domain found in Mycobacterium tuberculosis transcriptional ...
 14-94 2.79e-11

forkhead associated (FHA) domain found in Mycobacterium tuberculosis transcriptional regulatory protein EmbR and similar proteins; EmbR is a transcriptional regulator of the embCAB operon encoding cell wall arabinosyltransferases (EmbC, -A, and -B), and is phosphorylated by the cognate mycobacterial serine/threonine protein kinase PknH. It interacts with RNA polymerase and possesses a phosphorylation-dependent ATPase activity. EmbR contains a regulatory C-terminal forkhead-associated (FHA) domain, which mediates binding to a threonine-phosphorylated site in PknH. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438721 [Multi-domain]  Cd Length: 89  Bit Score: 60.12  E-value: 2.79e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505162042  14 EQREYHKPEITIGRLPGNDIMLAKGNVSKYHSRIVAKDGKCIIVDMKSTNGTFVNGKKIAAPQVLKPTDEIYIGDYIINV 93
Cdd:cd22669    9 RGYPLQAAATRIGRLHDNDIVLDSANVSRHHAVIVDTGTNYVINDLRSSNGVHVQHERIRSAVTLNDGDHIRICDHEFTF 88


                 .
gi 505162042  94 E 94
Cdd:cd22669   89 Q 89
FHA_PP2C70-like cd22678
forkhead associated (FHA) domain found in Arabidopsis thaliana protein phosphatase 2C 70 ...
 22-94 1.41e-10

forkhead associated (FHA) domain found in Arabidopsis thaliana protein phosphatase 2C 70 (AtPP2C70) and similar proteins; AtPP2C70, also called kinase-associated protein phosphatase, or protein ROOT ATTENUATED GROWTH 1, dephosphorylates the serine/threonine receptor-like kinase RLK5. It may function as a signaling component in a pathway involving RLK5. It acts as a negative regulator of the CLAVATA1 signaling in plant development by binding and dephosphorylating CLAVATA1. It is also a component of a signaling pathway which mediates adaptation to NaCl stress. It contains an FHA domain, which is a small phosphopeptide recognition module.


Pssm-ID: 438730 [Multi-domain]  Cd Length: 102  Bit Score: 58.53  E-value: 1.41e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 505162042  22 EITIGRLPGNDIMLAKGNVSKYHSRI--VAKDGKCIIVDMKSTNGTFVNGKKIAA---PQVLKPTDEIYIGDY-IINVE 94
Cdd:cd22678   24 PLTIGRIQRGDIALKDDEVSGKHARIewNSTGSKWELVDLGSLNGTLVNGESISPngrPVVLSSGDVITLGSEtKILVR 102
FHA_AGGF1 cd22686
forkhead associated (FHA) domain found in angiogenic factor with G patch and FHA domains 1 ...
 24-88 3.13e-10

forkhead associated (FHA) domain found in angiogenic factor with G patch and FHA domains 1 (AGGF1) and similar proteins; AGGF1, also called angiogenic factor VG5Q, or G patch domain-containing protein 7 (GPATC7), or vasculogenesis gene on 5q protein, is an angiogenic factor involved in vascular development, angiogenesis, specification of hemangioblasts, and differentiation of veins. It promotes angiogenesis and the proliferation of endothelial cells. It inhibits inflammatory effect and preserve vascular integrity in non-nervous system diseases. Mutated AGGF1 causes susceptibility to Klippel-Trenaunay syndrome, a vascular disorder. Increased AGGF1 expression is associated with tumor angiogenesis. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438738 [Multi-domain]  Cd Length: 123  Bit Score: 58.06  E-value: 3.13e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 505162042  24 TIGRLPGN--DIMLAKGNVSKYHSRIV--AKDGKCIIVDMKSTNGTFVNGKKIAA------PQVLKPTDEIYIGD 88
Cdd:cd22686   29 TIGREKDHghTIRIPELGVSKFHAEIYydDDEQSYTIVDLGSQNGTYLNGVRISQpkeksdPYPLTHGDELKIGE 103
DotB_TraJ cd19516
dot/icm secretion system protein DotB-like; Defect in organelle trafficking (Dot)B is part of ...
 438-528 4.15e-10

dot/icm secretion system protein DotB-like; Defect in organelle trafficking (Dot)B is part of the type IVb secretion (T4bS) system, also known as the dot/icm system, and is the main energy supplier of the secretion system. It is an ATPase, similar to the VirB11 component of the T4aS systems. This family also includes Escherichia coli IncI plasmid-encoded conjugative transfer ATPase TraJ encoded on the tra (transfer) operon.


Pssm-ID: 410924 [Multi-domain]  Cd Length: 179  Bit Score: 59.31  E-value: 4.15e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505162042 438 VKNCLRMRPDRIVVGECRSGETLD-MLQAMNTGHDgSLTTLHANTPRDAIARLETMVlmSGMELPVKAIReqIASAVHMI 516
Cdd:cd19516   82 VREALRRKPSLIGVGELRDQETISaAVEASLTGHP-VYSTVHTKSVAETIRRLISLF--PPEERDAAAYD--LLSTLRFI 156

                         90
                 ....*....|....
gi 505162042 517 VQQT--RFSDGTRK 528
Cdd:cd19516  157 IVQRlvRTTDGKRV 170
FHA_Rv1747-like_rpt1 cd22694
first forkhead associated (FHA) domain found in Mycobacterium tuberculosis ABC transporter ...
 9-88 6.47e-10

first forkhead associated (FHA) domain found in Mycobacterium tuberculosis ABC transporter ATP-binding/permease protein Rv1747 and similar proteins; Rv1747 is a putative ATP-binding cassette (ABC) transporter involved in the translocation of an unknown substrate across the membrane. It is required for normal virulent infection by M. tuberculosis. Rv1747 has a cytoplasmic regulatory module consisting of two pThr-interacting forkhead-associated (FHA) domains connected by a conformationally disordered linker with two phospho-acceptor threonines (pThr). Recruitment and phosphorylation of Rv1747 depend on the interaction between its two non-redundant FHA domains and the autophosphorylated form of serine/threonine protein kinase PknF. This model corresponds to the first FHA domain. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438746 [Multi-domain]  Cd Length: 93  Bit Score: 56.18  E-value: 6.47e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505162042   9 KGGGTEQREYHKPEITIGRLPGNDIMLAKGNVSKYHSRIVAKDGKCIIVDMKSTNGTFVNGKKIAApQVLKPTDEIYIGD 88
Cdd:cd22694    4 RIPGGELRFDPGSSVRIGRDPDADVRLDDPRVSRRHALLEFDGDGWVYTDLGSRNGTYLNGRRVQQ-VKLSDGTRVRLGD 82
FHA_FhaA-like cd22668
forkhead associated (FHA) domain found in Mycobacterium tuberculosis FHA domain-containing ...
 16-87 2.68e-09

forkhead associated (FHA) domain found in Mycobacterium tuberculosis FHA domain-containing protein FhaA and similar proteins; FhaA regulates cell growth and peptidoglycan synthesis by binding to MviN. It may inhibit the late stages of peptidoglycan synthesis. It contains an FHA domain, which is a small phosphopeptide recognition module.


Pssm-ID: 438720 [Multi-domain]  Cd Length: 91  Bit Score: 54.39  E-value: 2.68e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 505162042  16 REYHKPE--ITIGRLPGNDIMLAKGNVSKYHSRIVAKDGKCIIVDMKSTNGTFVNGKKIAAPQVLKPTDEIYIG 87
Cdd:cd22668   11 RVYQLREgsNIIGRGSDADFRLPDTGVSRRHAEIRWDGQVAHLTDLGSTNGTTVNNAPVTPEWRLADGDVITLG 84
FHA smart00240
Forkhead associated domain; Found in eukaryotic and prokaryotic proteins. Putative nuclear ...
 23-72 3.80e-09

Forkhead associated domain; Found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain.


Pssm-ID: 214578 [Multi-domain]  Cd Length: 52  Bit Score: 52.57  E-value: 3.80e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 505162042    23 ITIGRLP-GNDIMLAKGNVSKYHSRIVAKDGKCI-IVDMKSTNGTFVNGKKI 72
Cdd:smart00240   1 VTIGRSSeDCDIQLDGPSISRRHAVIVYDGGGRFyLIDLGSTNGTFVNGKRI 52
FHA_GarA_OdhI-like cd22684
forkhead associated (FHA) domain found in Mycobacterium tuberculosis GarA, Corynebacterium ...
 21-89 6.03e-09

forkhead associated (FHA) domain found in Mycobacterium tuberculosis GarA, Corynebacterium glutamicum OdhI and similar proteins; This family includes Mycobacterium tuberculosis glycogen accumulation regulator GarA and Corynebacterium glutamicum oxoglutarate dehydrogenase inhibitor (OdhI). GarA is involved in the regulation of glutamate metabolism. It acts as a phosphorylation-dependent molecular switch that modulates the activities of Kgd, Gdh and GltB. GarA binds to Kgd, Gdh, GltB, PknB, and the N-terminal region of PknG via its FHA domain. OdhI is an essential component of the PknG signaling pathway. It can inhibit the activity of 2-oxoglutarate dehydrogenase only when it is unphosphorylated. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438736 [Multi-domain]  Cd Length: 94  Bit Score: 53.54  E-value: 6.03e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 505162042  21 PEITIGRLPGNDIMLAKGNVSKYHSRIVAKDGKCIIVDMKSTNGTFVNGKKIAApQVLKPTDEIYIGDY 89
Cdd:cd22684   21 DVTTAGRHPESDIFLDDVTVSRRHAEFRRAEGGFVVRDVGSLNGTYVNRERIDS-AVLRNGDEVQIGKF 88
FHA_DUN1-like cd22683
forkhead associated (FHA) domain found in Saccharomyces cerevisiae DNA damage response protein ...
 20-90 1.22e-08

forkhead associated (FHA) domain found in Saccharomyces cerevisiae DNA damage response protein kinase DUN1 and similar proteins; DUN1 is a protein kinase that controls the DNA damage response in yeast. It phosphorylates SML1 on serine residues and cooperates with the PAN deadenylation complex in the regulation of RAD5 mRNA levels and cell survival in response to replicational stress. It contains an FHA domain, which is a small phosphopeptide recognition module.


Pssm-ID: 438735 [Multi-domain]  Cd Length: 96  Bit Score: 52.49  E-value: 1.22e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 505162042  20 KPEITIGRLPGNDIMLAKGNVSKYHSRIVAKDGKCIIVDMKSTNGTFVNGKKIAapqvlKPTDEIYIGDYI 90
Cdd:cd22683   20 RNVTTIGRSRSCDLVLSDPSISRFHAELRLEQNGINVIDNNSANGTFINGKRIK-----GKTYILKNGDII 85
FHA_CHFR cd22672
forkhead associated (FHA) domain found in checkpoint with forkhead and RING finger domains ...
 20-86 9.37e-08

forkhead associated (FHA) domain found in checkpoint with forkhead and RING finger domains protein (CHFR); CHFR, also called RING finger protein 196 (RNF196), is a checkpoint protein that delays entry into mitosis in response to stress. It functions as an E3 ubiquitin ligase that ubiquitinates and degrades its target proteins, such as Aurora-A, Plk1, Kif22 and PARP-1, which are critical for proper mitotic transitions. It also plays an important role in cell cycle progression and tumor suppression and is negatively regulated by SUMOylation-mediated proteasomal ubiquitylation. Moreover, CHFR is involved in the early stage of the DNA damage response, which mediates the crosstalk between ubiquitination and poly-ADP-ribosylation. CHFR contains a fork head associated-(FHA) domain and a RING-HC finger. The CHFR FHA domain has been crystallized as a segment-swapped dimer. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438724 [Multi-domain]  Cd Length: 108  Bit Score: 50.37  E-value: 9.37e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 505162042  20 KPEITIGRLPGNDIMLAkGN--VSKYHSRIVA-KDGKCIIVDMkSTNGTFVNGKKIAAPQV--LKPTDEIYI 86
Cdd:cd22672   20 KDEFTIGRAKDCDLSFP-GNklVSGDHCKIIRdEKGQVWLEDT-STNGTLVNKVKVVKGQKveLKHGDVIYL 89
FHA_Ct664-like cd22696
forkhead associated (FHA) domain found in Chlamydia trachomatis Ct664 protein and similar ...
 24-87 1.27e-07

forkhead associated (FHA) domain found in Chlamydia trachomatis Ct664 protein and similar proteins; This subfamily corresponds to a group of uncharacterized FHA domain-containing proteins which show high sequence similarity with Chlamydia trachomatis Ct664 protein. Ct664 situates within the type III secretion system cluster that also encodes an STPK (CT673 in C. trachomatis), suggesting a role of CT664 in the chlamydial type III secretion system by mediating phosphorylation-dependent protein-protein interactions. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438748 [Multi-domain]  Cd Length: 97  Bit Score: 49.80  E-value: 1.27e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 505162042  24 TIGRLPGN-DIMLAKGNVSKYHSRI-VAKDGKCIIVDMKSTNGTFVNGKKIAAPQVLKPTDEIYIG 87
Cdd:cd22696   24 FIGKDPTVcDIVLQDPSISRQHARLsIDQDNRVFIEDLSSKNGVLVNGKPIEGKEEISGSDVISLG 89
FHA_RNF8 cd22663
forkhead associated (FHA) domain found in RING finger protein 8 (RNF8) and similar proteins; ...
 22-97 1.31e-07

forkhead associated (FHA) domain found in RING finger protein 8 (RNF8) and similar proteins; RNF8 is a telomere-associated E3 ubiquitin-protein ligase that plays an important role in DNA double-strand break (DSB) repair via histone ubiquitination. It is localized in the nucleus and interacts with class III E2s (UBE2E2, UbcH6, and UBE2E3), but not with other E2s (UbcH5, UbcH7, UbcH10, hCdc34, and hBendless). It recruits UBC13 for lysine 63-based self polyubiquitylation. Its deficiency causes neuronal pathology and cognitive decline, and its loss results in neuron degeneration. RNF8, together with RNF168, catalyzes a series of ubiquitylation events on substrates such as H2A and H2AX, with the H2AK13/15 ubiquitylation being particularly important for recruitment of repair factors p53-binding protein 1 (53BP1) or the RAP80-BRCA1 complex to sites of DSBs. Specially, RNF8 mediates the ubiquitination of gammaH2AX, and recruits 53BP1 and BRCA1 to DNA damage sites which promotes DNA damage response (DDR) and inhibits chromosomal instability. Moreover, RNF8 interacts with retinoid X receptor alpha (RXR alpha) and enhances its transcription-stimulating activity. It also regulates the rate of exit from mitosis and cytokinesis. RNF8 contains an N-terminal FHA domain, which is a small phosphopeptide recognition module.


Pssm-ID: 438715 [Multi-domain]  Cd Length: 110  Bit Score: 50.05  E-value: 1.31e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505162042  22 EITIGRLPG--NDIMLAKG-NVSKYHSRIVAKD-GKCIIVDMKSTNGTFVNGKKIAA--PQVLKPTDEIYIGDYIINVEP 95
Cdd:cd22663   22 EVTVGRGLGvtYQLVSTCPlMISRNHCVLKKNDeGQWTIKDNKSLNGVWVNGERIEPlkPYPLNEGDLIQLGVPPENKEP 101


                 ..
gi 505162042  96 LE 97
Cdd:cd22663  102 AE 103
VI_FHA TIGR03354
type VI secretion system FHA domain protein; Members of this protein family are FHA ...
 4-107 1.69e-07

type VI secretion system FHA domain protein; Members of this protein family are FHA (forkhead-associated) domain-containing proteins that are part of type VI secretion loci in a considerable number of bacteria, most of which are known pathogens. Species include Pseudomonas aeruginosa PAO1, Aeromonas hydrophila, Yersinia pestis, Burkholderia mallei, etc. [Protein fate, Protein and peptide secretion and trafficking, Cellular processes, Pathogenesis]


Pssm-ID: 274537 [Multi-domain]  Cd Length: 396  Bit Score: 53.91  E-value: 1.69e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505162042    4 ITLAEKGGGTEQREY--HKPEITIGRLPGNDIML--AKGNVSKYHSRIVAKDGKCIIVDMkSTNGTFVNGKKI----AAP 75
Cdd:TIGR03354   5 VLNAHQLTPGIAAQKtfGTNGGTIGRSEDCDWVLpdPERHVSGRHARIRYRDGAYLLTDL-STNGVFLNGSGSplgrGNP 83

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 505162042   76 QVLKPTDEIYIGDYIINV---EPLEDAGPAMTRAG 107
Cdd:TIGR03354  84 VRLEQGDRLRLGDYEIRVslgDPLVSRQASESRAD 118
FHA_Kanadaptin cd22677
forkhead associated (FHA) domain found in kanadaptin and similar proteins; Kanadaptin, also ...
 20-72 2.22e-07

forkhead associated (FHA) domain found in kanadaptin and similar proteins; Kanadaptin, also called human lung cancer oncogene 3 protein (HLC-3), kidney anion exchanger adapter protein, or solute carrier family 4 anion exchanger member 1 adapter protein (SLC4A1AP), is a nuclear protein widely expressed in mammalian tissues. It was originally isolated as a kidney Cl-/HCO3- anion exchanger 1 (kAE1)-binding protein. It is a highly mobile nucleocytoplasmic shuttling and multilocalizing protein. Its role in mammalian cells remains unclear. It contains an FHA domain, which is a small phosphopeptide recognition module.


Pssm-ID: 438729 [Multi-domain]  Cd Length: 106  Bit Score: 49.48  E-value: 2.22e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 505162042  20 KPEITIGRLPGNDIMLAKGNVSKYH------SRIVAKDGKCIIVDMKSTNGTFVNGKKI 72
Cdd:cd22677   21 KSFYVFGRLPGCDVVLEHPSISRYHavlqyrGDADDHDGGFYLYDLGSTHGTFLNKQRI 79
FHA_RAD53-like_rpt1 cd22689
first forkhead associated (FHA) domain found in Saccharomyces cerevisiae Serine ...
 19-87 2.81e-07

first forkhead associated (FHA) domain found in Saccharomyces cerevisiae Serine/threonine-protein kinase RAD53 and similar proteins; RAD53, also called CHEK2 homolog, or serine-protein kinase 1 (Spk1), is a nuclear protein kinase that phosphorylates proteins on serine, threonine, and tyrosine. It controls S-phase checkpoint as well as G1 and G2 DNA damage checkpoints and prevents entry into anaphase and mitotic exit after DNA damage via regulation of the Polo kinase CDC5. It may be involved in the phosphorylation of RPH1. RAD53 contains two FHA domains. This model corresponds to the first one. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438741 [Multi-domain]  Cd Length: 132  Bit Score: 49.97  E-value: 2.81e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 505162042  19 HKPEITIGRLPGNDIMLAKGNVSKYHSRIV-----AKDGKCIIVDMkSTNGTFVNGKKIA--APQVLKPTDEIYIG 87
Cdd:cd22689   43 IKKVWTFGRHPACDYHLGNSRLSNKHFQILlgesdPSDGNVLLNDI-SSNGTWLNGQRLEknSNQLLSQGDEITIG 117
FHA_ZEP-like cd22702
forkhead associated (FHA) domain found in chloroplastic zeaxanthin epoxidase (ZEP) and similar ...
 2-87 3.40e-07

forkhead associated (FHA) domain found in chloroplastic zeaxanthin epoxidase (ZEP) and similar proteins; ZEP, also called protein ABA DEFICIENT 1, ABA1, protein IMPAIRED IN BABA-INDUCED STERILITY 3, protein LOW EXPRESSION OF OSMOTIC STRESS-RESPONSIVE GENES 6, or protein NON-PHOTOCHEMICAL QUENCHING 2, plays an important role in the xanthophyll cycle and abscisic acid (ABA) biosynthesis. It converts zeaxanthin into antheraxanthin and subsequently violaxanthin. ZEP is required for resistance to osmotic and drought stresses, ABA-dependent stomatal closure, seed development and dormancy, modulation of defense gene expression, and disease resistance and non-photochemical quencing (NPQ). The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438754 [Multi-domain]  Cd Length: 123  Bit Score: 49.35  E-value: 3.40e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505162042   2 FLITLAEKGGGTEQREYHKPE---ITIGRLP-----GNDIMLAKGNVSKYHSRIVAKDGKCIIVDMKSTNGTFVNGKKIA 73
Cdd:cd22702   10 YLLPLGNDMDGGSPIRLTRDEkqpCIIGSDPhqaisGISVVIPSPQVSELHARITCKNGAFFLTDLGSEHGTWINDNEGR 89

                         90       100
                 ....*....|....*....|.
gi 505162042  74 A-------PQVLKPTDEIYIG 87
Cdd:cd22702   90 RyrappnfPVRLHPSDVIEFG 110
PilT COG2805
Type IV pilus assembly protein PilT, pilus retraction ATPase [Cell motility, Extracellular ...
 438-520 5.99e-07

Type IV pilus assembly protein PilT, pilus retraction ATPase [Cell motility, Extracellular structures];


Pssm-ID: 442056  Cd Length: 342  Bit Score: 51.63  E-value: 5.99e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505162042 438 VKNCLRMRPDRIVVGECRSGETLDM-LQAMNTGHdgsL--TTLHANTPRDAIARLETMVlmsgmelPV---KAIREQIAS 511
Cdd:COG2805  191 LRAALREDPDVILVGEMRDLETIEAaLTAAETGH---LvfATLHTNSAAQTIDRIIDVF-------PPeeqAQIRSQLAE 260


                 ....*....
gi 505162042 512 AVHMIVQQT 520
Cdd:COG2805  261 SLRGVISQR 269
FHA_Slr1951-like cd22697
forkhead associated (FHA) domain found in Synechocystis sp. Slr1951 protein and similar ...
 4-91 1.58e-06

forkhead associated (FHA) domain found in Synechocystis sp. Slr1951 protein and similar proteins; This subfamily corresponds to a group of uncharacterized FHA domain-containing proteins which show high sequence similarity with Synechocystis sp. protein Slr1951 and protein Sll1895. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438749 [Multi-domain]  Cd Length: 102  Bit Score: 46.69  E-value: 1.58e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505162042   4 ITLAEKGGGTEQREYHKPEITIGRLPGNDIMLAKGNVSKYHSRIVAK-----DGKCIIVD-----MKSTNGTFVNGKKIA 73
Cdd:cd22697    1 ILVELDGNVRREIRLDEPIYTIGRHPGNDIQIPSQQISRRHATLRRKinpnlDISFWIIDgdlegAESLNGLWVNGERIL 80

                         90
                 ....*....|....*...
gi 505162042  74 ApQVLKPTDEIYIGDYII 91
Cdd:cd22697   81 Q-HELVNGDEIALGPKIV 97
FHA_PS1-like cd22691
forkhead associated (FHA) domain found in Arabidopsis thaliana Protein PARALLEL SPINDLE 1 (PS1) ...
 21-87 1.90e-06

forkhead associated (FHA) domain found in Arabidopsis thaliana Protein PARALLEL SPINDLE 1 (PS1) and similar proteins; PS1 is an FHA domain-containing protein required for normal spindle orientation at male meiosis II and normal formation of tetrad of microspores. It is not involved in female meiosis. Mutations in PS1 lead to the production of diploid pollen grains. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438743 [Multi-domain]  Cd Length: 113  Bit Score: 47.03  E-value: 1.90e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 505162042  21 PEITIGRLPGNDIMLAKGNVSKYHSRI--VAKDGKCIIVDMKSTNGTFVNGKKIAA--PQVLKPTDEIYIG 87
Cdd:cd22691   29 DILVVGRHPDCDIVLDHPSISRFHLEIriIPSRRKITLTDLSSVHGTWVNGQRIEPgvPVELEEGDTVRLG 99
PilT cd01131
Pilus retraction ATPase PilT; Pilus retraction ATPase PilT is a nucleotide-binding protein ...
 439-520 2.92e-06

Pilus retraction ATPase PilT; Pilus retraction ATPase PilT is a nucleotide-binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism known as twitching motility.


Pssm-ID: 410875 [Multi-domain]  Cd Length: 223  Bit Score: 48.69  E-value: 2.92e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505162042 439 KNCLRMRPDRIVVGECRSGETLDM-LQAMNTGHDgSLTTLHANTPRDAIARLETMVLMSGMElpvkAIREQIASAVHMIV 517
Cdd:cd01131   88 RAALREDPDVILVGEMRDLETIELaLTAAETGHL-VFSTLHTNSAAQTIDRIIDVFPPEQQE----QVRIQLASSLRGVI 162


                 ...
gi 505162042 518 QQT 520
Cdd:cd01131  163 SQR 165
PulE COG2804
Type II secretory pathway ATPase GspE/PulE or T4P pilus assembly pathway ATPase PilB [Cell ...
 392-530 4.65e-06

Type II secretory pathway ATPase GspE/PulE or T4P pilus assembly pathway ATPase PilB [Cell motility, Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 442055 [Multi-domain]  Cd Length: 561  Bit Score: 49.42  E-value: 4.65e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505162042 392 AFIPDSER-IVTVEDAAELQLP---QdhwVQLESRppnlegKG---AITIRDLvkncLRMRPDRIVVGECRSGETLDM-L 463
Cdd:COG2804  335 NELNTPERnIITVEDPVEYQLPginQ---VQVNPK------IGltfASALRSI----LRQDPDVIMVGEIRDLETAEIaV 401

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 505162042 464 QAMNTGHdGSLTTLHANTPRDAIARLETMvlmsGMElpvkaiREQIASAVHMIVQQtRFsdgTRKIC 530
Cdd:COG2804  402 QAALTGH-LVLSTLHTNDAPSAITRLLDM----GVE------PFLLASSLLGVLAQ-RL---VRRLC 453
FHA_GarA-like cd22720
forkhead associated (FHA) domain found in Mycobacterium tuberculosis glycogen accumulation ...
 20-89 4.81e-06

forkhead associated (FHA) domain found in Mycobacterium tuberculosis glycogen accumulation regulator GarA and similar proteins; GarA is an FHA domain-containing protein involved in the regulation of glutamate metabolism. It acts as a phosphorylation-dependent ON/OFF molecular switch that modulates the activities of KGD, GDH and GltB. Its FHA domain has dual specificity. It binds to both phosphorylated upstream partners, such as the kinases PknB and PknG, and nonphosphorylated downstream partners, such as the 2-oxoglutarate decarboxylase KGD. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438772 [Multi-domain]  Cd Length: 100  Bit Score: 45.38  E-value: 4.81e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505162042  20 KPEITIGRLPGNDIMLAKGNVSKYHSRIVAKDGKCIIVDMKSTNGTFVNGKKIAApQVLKPTDEIYIGDY 89
Cdd:cd22720   23 QAITSAGRHPDSDIFLDDVTVSRRHAEFRLENNEFNVVDVGSLNGTYVNREPVDS-AVLANGDEVQIGKF 91
FHA_SLMAP cd22679
forkhead associated (FHA) domain found in sarcolemmal membrane-associated protein (SLMAP) and ...
 41-90 9.44e-06

forkhead associated (FHA) domain found in sarcolemmal membrane-associated protein (SLMAP) and similar proteins; SLMAP, also called sarcolemmal-associated protein (SLAP), is a tail-anchored protein involved in fundamental cellular processes, such as myoblast fusion, cell cycle progression, and chromosomal inheritance. It is a cardiac membrane protein that plays an important role in E-C coupling and the adrenergic response of the heart. Overexpression of the SLMAP gene has been associated with diabetes and endothelial dysfunction of macro- and micro-blood vessels. SLMAP contains an N-terminal FHA domain, which is a small phosphopeptide recognition module.


Pssm-ID: 438731 [Multi-domain]  Cd Length: 126  Bit Score: 45.34  E-value: 9.44e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 505162042  41 SKYHSRIVAKDGKCIIVDMKSTNGTFVNGKKIAAPQVLKPTDEIYIGDYI 90
Cdd:cd22679   50 SRNHALLWYDDGKFYLQDTKSSNGTFVNNQRLSKGSEESEPRELHSGDIV 99
PRK10436 PRK10436
hypothetical protein; Provisional
 442-530 1.01e-05

hypothetical protein; Provisional


Pssm-ID: 236694  Cd Length: 462  Bit Score: 48.39  E-value: 1.01e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505162042 442 LRMRPDRIVVGECRSGETLDM-LQAMNTGHDgSLTTLHANTPRDAIARLETMvlmsGMElpvkaiREQIASAVHMIVQQt 520
Cdd:PRK10436 284 LRQDPDVIMVGEIRDGETAEIaIKAAQTGHL-VLSTLHTNSTSETLVRLQQM----GIA------RWMLASALKLVIAQ- 351

                         90
                 ....*....|
gi 505162042 521 RFsdgTRKIC 530
Cdd:PRK10436 352 RL---VRKLC 358
Yop-YscD_cpl pfam16697
Inner membrane component of T3SS, cytoplasmic domain; Yop-YscD-cpl is the cytoplasmic domain ...
 19-87 1.09e-05

Inner membrane component of T3SS, cytoplasmic domain; Yop-YscD-cpl is the cytoplasmic domain of Yop proteins like YscD from Proteobacteria. YscD forms part of the inner membrane component of the bacterial type III secretion injectosome apparatus.


Pssm-ID: 465238 [Multi-domain]  Cd Length: 94  Bit Score: 44.17  E-value: 1.09e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505162042   19 HKPEITIGRLPGNDIMLAKGNVSKYHSRIVAKDGKCIIVDMKSTNGTFVNGKKIAAPQV-LKPTDEIYIG 87
Cdd:pfam16697  15 EGGRYRIGSDPDCDIVLSDKEVSRVHLKLEVDDEGWRLDDLGSGNGTLVNGQRVTELGIaLRPGDRIELG 84
FHA_OdhI-like cd22721
forkhead associated (FHA) domain found in Corynebacterium glutamicum oxoglutarate ...
 24-89 1.62e-05

forkhead associated (FHA) domain found in Corynebacterium glutamicum oxoglutarate dehydrogenase inhibitor (OdhI) and similar proteins; OdhI is an essential component of the PknG signaling pathway. It regulates glutamate production under biotin non-limiting conditions. It can inhibit the activity of 2-oxoglutarate dehydrogenase only when it is unphosphorylated. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438773 [Multi-domain]  Cd Length: 102  Bit Score: 43.92  E-value: 1.62e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 505162042  24 TIGRLPGNDIMLAKGNVSKYHSRIVAKDGKCIIVDMKSTNGTFVNgKKIAAPQVLKPTDEIYIGDY 89
Cdd:cd22721   32 TAGRHPESDIFLDDVTVSRRHAEFRINEGEFEVVDVGSLNGTYVN-REPRNAQVMQTGDEIQIGKF 96
FHA_RAD53-like_rpt2 cd22690
second forkhead associated (FHA) domain found in Saccharomyces cerevisiae Serine ...
 22-86 1.70e-05

second forkhead associated (FHA) domain found in Saccharomyces cerevisiae Serine/threonine-protein kinase RAD53 and similar proteins; RAD53, also called CHEK2 homolog, or serine-protein kinase 1 (Spk1), is a nuclear protein kinase that phosphorylates proteins on serine, threonine, and tyrosine. It controls S-phase checkpoint as well as G1 and G2 DNA damage checkpoints and prevents entry into anaphase and mitotic exit after DNA damage via regulation of the Polo kinase CDC5. It may be involved in the phosphorylation of RPH1. RAD53 contains two FHA domains. This model corresponds to the second one. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438742 [Multi-domain]  Cd Length: 105  Bit Score: 43.82  E-value: 1.70e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 505162042  22 EITIGRLPGNDIMLAKGNVSKYHSRIVAKD-----GKCIIVDMkSTNGTFVNGKKIAAPQ--VLKPTDEIYI 86
Cdd:cd22690   20 TTFIGRSKDCDEEITDPRISKHHCIITRKRsgkglDDVYVTDT-STNGTFINNNRLGKGSqsLLQDGDEIVL 90
FHA_MEK1-like cd22670
forkhead associated (FHA) domain found in Saccharomyces cerevisiae meiosis-specific serine ...
 22-88 5.33e-05

forkhead associated (FHA) domain found in Saccharomyces cerevisiae meiosis-specific serine/threonine-protein kinase MEK1 and similar proteins; MEK1 (EC 2.7.11.1), also known as MRE4, is a meiosis-specific protein kinase required for chromosome synapsis and meiotic recombination. The recruitment and activation of MEK1 require the phosphorylation of the chromosome axis protein Hop1 at Thr318 (pT318), which is necessary for recognition by the MEK1 FHA domain. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438722 [Multi-domain]  Cd Length: 105  Bit Score: 42.60  E-value: 5.33e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 505162042  22 EITIGRLPGNDIMLAKGNVSKYHSRI--VAKDG----KCIIVDmKSTNGTFVNGKKIAAPQ--VLKPTDEIYIGD 88
Cdd:cd22670   23 VITIGRSPSCDIVINDPFVSRTHCRIysVQFDEssapLVYVED-LSSNGTYLNGKLIGRNNtvLLSDGDVIEIAH 96
FHA_VPS64-like cd22695
forkhead associated (FHA) domain found in Saccharomyces cerevisiae vacuolar protein ...
 40-90 8.73e-05

forkhead associated (FHA) domain found in Saccharomyces cerevisiae vacuolar protein sorting-associated protein 64 (VPS64) and similar proteins; This subfamily includes VPS64 (also called factor arrest protein 9 or FAR9) and factor arrest protein 10 (FAR10), which participate in the control of the re-entry into the cell cycle following pheromone treatment. VPS64 is also involved in vacuolar protein sorting. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438747 [Multi-domain]  Cd Length: 133  Bit Score: 42.67  E-value: 8.73e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 505162042  40 VSKYHSRIVA--KDGKCIIVDMKSTNGTFVNGKKIAAPQV-LKPTDEIYIGDYI 90
Cdd:cd22695   65 LSRNHACLSCdpTTGKVYIRDLKSSNGTFVNGQKIRQNDVeLKVGDEVDLGTDI 118
FHA_NBN cd22667
forkhead associated (FHA) domain found in nibrin and similar proteins; Nibrin (NBN), also ...
 1-87 1.06e-04

forkhead associated (FHA) domain found in nibrin and similar proteins; Nibrin (NBN), also called cell cycle regulatory protein p95, or Nijmegen breakage syndrome protein 1 (NBS1), is a novel DNA double-strand break repair protein that is mutated in Nijmegen breakage syndrome. It is a component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. Nibrin modulates the DNA damage signal sensing by recruiting PI3/PI4-kinase family members ATM, ATR, and probably DNA-dependent protein kinase catalytic subunit (DNA-PKcs) to the DNA damage sites and activating their functions. It can also recruit MRE11 and RAD50 to the proximity of DSBs by an interaction with the histone H2AX. Nibrin also functions in telomere length maintenance by generating the 3' overhang which serves as a primer for telomerase dependent telomere elongation. Nibrin is a major player in the control of intra-S-phase checkpoint. This subfamily also includes Schizosaccharomyces pombe DNA repair and telomere maintenance protein Nbs1 and Arabidopsis thaliana AtNbs1. SpNbs1 is an FHA domain-containing protein required for DNA damage repair and S-phase DNA damage checkpoint. It is involved in telomere length maintenance and maintenance of chromatin structure. AtNbs1 is a component of MRN complex. It also functions in the very early stages of meiosis. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438719 [Multi-domain]  Cd Length: 108  Bit Score: 41.93  E-value: 1.06e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505162042   1 MFLITLAEKGGG----TEQREYhkpeiTIGRLPGNDIMLAKGNVSKYHSRIVAKDG-----------KCIIVDMkSTNGT 65
Cdd:cd22667    1 WWLLSEQDGAGTsyylLPGGEY-----TVGRKDCDIIIVDDSSISRKHATLTVLHPeanlsdpdtrpELTLKDL-SKYGT 74

                         90       100
                 ....*....|....*....|....
gi 505162042  66 FVNGKKIAA--PQVLKPTDEIYIG 87
Cdd:cd22667   75 FVNGEKLKGgsEVTLKDGDVITFG 98
FHA_FHAD1 cd22700
forkhead associated (FHA) domain found in forkhead-associated domain-containing protein 1 ...
 24-87 1.71e-04

forkhead associated (FHA) domain found in forkhead-associated domain-containing protein 1 (FHAD1) and similar proteins; FHAD1, also called FHA domain-containing protein 1, is an uncharacterized FHA domain-containing protein. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438752 [Multi-domain]  Cd Length: 96  Bit Score: 40.70  E-value: 1.71e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 505162042  24 TIGRlPGNDIMLAKGNVSKYHSRI--VAKDGKCIIVDMKSTNGTFVNGKKI--AAPQvLKPTDEIYIG 87
Cdd:cd22700   19 TIGR-EGCDLVLQSPGVEEQHAVIeySEQENCFVLQDLNTAQGTYVNDCRIqnAAVR-LAPGDVLRFG 84
FHA_PPP1R8 cd22674
forkhead associated (FHA) domain found in protein phosphatase 1 regulatory inhibitor subunit 8 ...
 24-87 2.92e-04

forkhead associated (FHA) domain found in protein phosphatase 1 regulatory inhibitor subunit 8 (PPP1R8) and similar proteins; PPP1R8, also called nuclear inhibitor of protein phosphatase 1 (NIPP-1), is an inhibitor subunit of the major nuclear protein phosphatase-1 (PP-1). It has RNA-binding activity but does not cleave RNA and may target PP-1 to RNA-associated substrates. It may also be involved in pre-mRNA splicing and binds DNA and might act as a transcriptional repressor. PPP1R8 seems to be required for cell proliferation. PPP1R8 contains an FHA domain that mediates interactions with threonine-phosphorylated maternal embryonic leucine zipper kinase (MELK). The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438726 [Multi-domain]  Cd Length: 108  Bit Score: 40.33  E-value: 2.92e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 505162042  24 TIGRLP-GNDIMLAKGNVSKYHSRIV--AKDGKCIIVDMKSTNGTFVNGKKIAA--PQVLKPTDEIYIG 87
Cdd:cd22674   30 LFGRNSdVCDFVLDHPSCSRVHAALVyhKHLNRVFLIDLGSTHGTFVGGIRLEPhkPQQLPIDSTLRFG 98
FHA_SNIP1_DDL-like cd22676
forkhead associated (FHA) domain found in Smad nuclear-interacting protein 1 (SNIP1), FHA ...
 40-87 3.38e-04

forkhead associated (FHA) domain found in Smad nuclear-interacting protein 1 (SNIP1), FHA domain-containing protein DDL, and similar proteins; SNIP1 is an FHA domain-containing protein required for pre-mRNA splicing as a component of the spliceosome. It inhibits NF-kappaB signaling by competing for its binding to the C/H1 domain of CBP/p300 transcriptional co-activators. It is involved in microRNA (miRNA) biogenesis. SNIP1 is a regulator of the cell cycle and cyclin D1 expression and may be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. This family also includes Arabidopsis thaliana FHA domain-containing protein DDL and similar proteins. DDL, also called protein DAWDLE, is involved in the microRNA (miRNA) and short interfering RNA (siRNA) biogenesis. It may facilitate DCL1 to access or recognize primary miRNAs. DDL binds RNA non-specifically. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438728 [Multi-domain]  Cd Length: 111  Bit Score: 40.36  E-value: 3.38e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 505162042  40 VSKYHSRIVAKDGKCIIVDMKSTNGTFVNGKKIaAPQV---LKPTDEIYIG 87
Cdd:cd22676   53 VEKRNEGDVIENIRPYIIDLGSTNGTFLNGEKI-EPRRyyeLREKDVLKFG 102
FHA_Cep170 cd22704
forkhead associated (FHA) domain found in the centrosomal protein of 170 kDa protein (Cep170) ...
 32-73 5.77e-04

forkhead associated (FHA) domain found in the centrosomal protein of 170 kDa protein (Cep170) family; The Cep170 family includes Cep170 and Cep170B. Cep170, also called Cep170A, KARP-1-binding protein, or KARP1-binding protein, is a protein that localizes to centrosomes as well as spindle microtubules and plays a role in microtubule organization and microtubule assembly. It is required for centriole subdistal appendage assembly. Cep170 is phosphorylated during M phase and interacts with Polo-like kinase 1 (Plk1). Cep170B, also called centrosomal protein 170B, plays a role in microtubule organization. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438756 [Multi-domain]  Cd Length: 102  Bit Score: 39.61  E-value: 5.77e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 505162042  32 DIMLAKGNVSKYHSRIV--AKDGKCIIVDMKSTNGTFVNGKKIA 73
Cdd:cd22704   27 DLILQSRSVDKQHAVITydQIDNEFKIKDLGSLNGTFVNDSRIP 70
PLN02927 PLN02927
antheraxanthin epoxidase/zeaxanthin epoxidase
 28-87 1.29e-03

antheraxanthin epoxidase/zeaxanthin epoxidase


Pssm-ID: 178515 [Multi-domain]  Cd Length: 668  Bit Score: 41.62  E-value: 1.29e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 505162042  28 LPGNDIMLAKGNVSKYHSRIVAKDGKCIIVDMKSTNGTFVN---GKKIAA----PQVLKPTDEIYIG 87
Cdd:PLN02927 569 FPGMRIVIPSSQVSKMHARVIYKDGAFFLMDLRSEHGTYVTdneGRRYRAtpnfPARFRSSDIIEFG 635
FHA_Par42-like cd22675
forkhead associated (FHA) domain found in Trypanosoma brucei Parvulin 42 (TbPar42) and similar ...
 21-74 3.16e-03

forkhead associated (FHA) domain found in Trypanosoma brucei Parvulin 42 (TbPar42) and similar proteins; TbPar42 is a nuclear protein that plays a key role in parasite cell proliferation. It exhibits an N-terminal forkhead associated (FHA)-domain and a peptidyl-prolyl-cis/trans-isomerase (PPIase) domain, both connected by a linker. Its PPIase domain adopts a parvulin fold and reflects structural elements of Pin1-type proteins but is catalytically inactive. Its FHA domain may be involved in the binding of phosphorylated target proteins. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438727 [Multi-domain]  Cd Length: 113  Bit Score: 37.54  E-value: 3.16e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 505162042  21 PEITIGRLPGNDIMLAKGNVSKYHSRIVAK-DGKC-IIVDMKSTNGTFVNGKKIAA 74
Cdd:cd22675   29 PFYLFGRSPVCDYVLEHPSISSVHAVLVFHgEQKCfVLMDLGSTNGVKLNGKRIEK 84
FHA_CHK2 cd22666
forkhead associated (FHA) domain found in checkpoint kinase 2 (Chk2) and similar proteins; ...
 20-84 4.33e-03

forkhead associated (FHA) domain found in checkpoint kinase 2 (Chk2) and similar proteins; Chk2, also called Hucds1, Cds1 homolog, or serine/threonine-protein kinase Chk2, plays an important role in cellular responses to DNA double-strand breaks and related lesions. It is phosphorylated and activated by ATM kinase, resulting in its dissociation from sites of damage to phosphorylate downstream targets such as BRCA1, p53, cell cycle transcription factor E2F1, the promyelocytic leukemia protein (PML) involved in apoptosis, and CDC25 phosphatases, among others. Mutations in Chk2 is linked to a variety of cancers including familial breast cancer, myelodysplastic syndromes, prostate cancer, lung cancer, and osteosarcomas. Chk2 contains an N-terminal SQ/TQ cluster domain (SCD), a central forkhead-associated (FHA) domain, and a C-terminal catalytic kinase domain. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438718 [Multi-domain]  Cd Length: 112  Bit Score: 37.22  E-value: 4.33e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505162042  20 KPEITIGRLPGNDI-----MLAKG----NVSKYHSRI--VAKDGKCIIV---DMkSTNGTFVNGKKIAA--PQVLKPTDE 83
Cdd:cd22666   18 KDEYTFGRDKSCDYcfdspALKKTsyyrTYSKKHFRIfrEKGSKNTYPVfleDH-SSNGTFVNGEKIGKgkKRPLNNNDE 96


                 .
gi 505162042  84 I 84
Cdd:cd22666   97 I 97
FHA_KIF28P cd22709
forkhead associated (FHA) domain found in kinesin-like protein KIF28P and similar proteins; ...
 22-87 4.69e-03

forkhead associated (FHA) domain found in kinesin-like protein KIF28P and similar proteins; KIF28P, also called kinesin-like protein 6 (KLP6), is a microtubule-dependent motor protein required for mitochondrion morphology and transport of mitochondria in neuronal cells. The FHA domain is a small phosphopeptide recognition module, but this group may lack the conserved residues that are required for binding phosphothreonine.


Pssm-ID: 438761 [Multi-domain]  Cd Length: 102  Bit Score: 36.81  E-value: 4.69e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 505162042  22 EITIGRL---PGNDIMLAKGNVSKYHSRIVAKDGKCII--VDMKSTngTFVNGKKIAAPQVLKPTDEIYIG 87
Cdd:cd22709   24 ETTIGRAdaePEPDIVLSGLSIQKQHAVITNTDGKVTIepVSPGAK--VIVNGVPVTGETELHHLDRVILG 92
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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