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Conserved domains on  [gi|505178930|ref|WP_015366032|]
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MULTISPECIES: PhoP/PhoQ regulator MgrB [Klebsiella]

Protein Classification

PhoP/PhoQ regulator MgrB( domain architecture ID 10013480)

PhoP/PhoQ regulator MgrB represses PhoP/PhoQ signaling, possibly by binding to the periplasmic domain of PhoQ, altering its activity and that of downstream effector PhoP

Gene Ontology:  GO:0070298

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PRK10299 PRK10299
PhoP/PhoQ regulator MgrB;
1-47 6.18e-20

PhoP/PhoQ regulator MgrB;


:

Pssm-ID: 182364  Cd Length: 47  Bit Score: 73.27  E-value: 6.18e-20
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*..
gi 505178930  1 MKKLRWVLLIVVIAGCLLLWTQMLNVMCDQDVQFFSGICAINKFIPW 47
Cdd:PRK10299  1 MKKFRWVVLVVVVLACLLLWAQVFNMMCDQDVQFFSGICAINKFIPW 47
 
Name Accession Description Interval E-value
PRK10299 PRK10299
PhoP/PhoQ regulator MgrB;
1-47 6.18e-20

PhoP/PhoQ regulator MgrB;


Pssm-ID: 182364  Cd Length: 47  Bit Score: 73.27  E-value: 6.18e-20
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*..
gi 505178930  1 MKKLRWVLLIVVIAGCLLLWTQMLNVMCDQDVQFFSGICAINKFIPW 47
Cdd:PRK10299  1 MKKFRWVVLVVVVLACLLLWAQVFNMMCDQDVQFFSGICAINKFIPW 47
MgrB pfam13998
MgrB protein; The MgrB protein is a short lipoprotein. The mgrB gene has a mg2+ responsive ...
19-47 3.26e-10

MgrB protein; The MgrB protein is a short lipoprotein. The mgrB gene has a mg2+ responsive promoter. Deletion of mgrB results in a potent increase in PhoP-regulated transcription. The PhoQ/PhoP signaling system responds to low magnesium and the presence of certain cationic antimicrobial peptides. Over-expression of mgrB decreased transcription at both high and low concentrations of magnesium. Localization and bacterial two-hybrid studies suggest that MgrB resides in the inner-membrane and interacts directly with PhoQ. This domain family is found in bacteria, and is approximately 40 amino acids in length. There are two conserved sequence motifs: CDQ and GIC.


Pssm-ID: 404818  Cd Length: 29  Bit Score: 48.18  E-value: 3.26e-10
                         10        20
                 ....*....|....*....|....*....
gi 505178930  19 LWTQMLNVMCDQDVQFFSGICAINKFIPW 47
Cdd:pfam13998  1 LYLLALDSYCDQGEDFFSGICSITKFLPW 29
 
Name Accession Description Interval E-value
PRK10299 PRK10299
PhoP/PhoQ regulator MgrB;
1-47 6.18e-20

PhoP/PhoQ regulator MgrB;


Pssm-ID: 182364  Cd Length: 47  Bit Score: 73.27  E-value: 6.18e-20
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*..
gi 505178930  1 MKKLRWVLLIVVIAGCLLLWTQMLNVMCDQDVQFFSGICAINKFIPW 47
Cdd:PRK10299  1 MKKFRWVVLVVVVLACLLLWAQVFNMMCDQDVQFFSGICAINKFIPW 47
MgrB pfam13998
MgrB protein; The MgrB protein is a short lipoprotein. The mgrB gene has a mg2+ responsive ...
19-47 3.26e-10

MgrB protein; The MgrB protein is a short lipoprotein. The mgrB gene has a mg2+ responsive promoter. Deletion of mgrB results in a potent increase in PhoP-regulated transcription. The PhoQ/PhoP signaling system responds to low magnesium and the presence of certain cationic antimicrobial peptides. Over-expression of mgrB decreased transcription at both high and low concentrations of magnesium. Localization and bacterial two-hybrid studies suggest that MgrB resides in the inner-membrane and interacts directly with PhoQ. This domain family is found in bacteria, and is approximately 40 amino acids in length. There are two conserved sequence motifs: CDQ and GIC.


Pssm-ID: 404818  Cd Length: 29  Bit Score: 48.18  E-value: 3.26e-10
                         10        20
                 ....*....|....*....|....*....
gi 505178930  19 LWTQMLNVMCDQDVQFFSGICAINKFIPW 47
Cdd:pfam13998  1 LYLLALDSYCDQGEDFFSGICSITKFLPW 29
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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