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Conserved domains on  [gi|505178969|ref|WP_015366071|]
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MULTISPECIES: membrane-bound lytic murein transglycosylase EmtA [Klebsiella]

Protein Classification

membrane-bound lytic murein transglycosylase EmtA( domain architecture ID 11487811)

membrane-bound lytic murein transglycosylase EmtA is a murein-degrading enzyme that may play a role in recycling of muropeptides during cell elongation and/or cell division

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
emtA PRK15470
membrane-bound lytic murein transglycosylase EmtA;
1-203 2.46e-155

membrane-bound lytic murein transglycosylase EmtA;


:

Pssm-ID: 185367 [Multi-domain]  Cd Length: 203  Bit Score: 427.84  E-value: 2.46e-155
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505178969   1 MKLRWFVFLFVLLAGCSSKHDYTNPPWNPEVPVKRSMQWMPISEKAGAAWGVDPQLITAIIAIESGGNPSVVSKSGAVGL 80
Cdd:PRK15470   1 MKLRWFAFLIVLLAGCSSKHDYTNPPWNAKVPVQRAMQWMPISQKAGAAWGVDPQLITAIIAIESGGNPNAVSKSNAIGL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505178969  81 MQLKPSTSGRDVYQRMGWRGQPSVSELKNPERNISMGAAYLSILENGPLAGIKDPQVMRYAVVVSYANGAGALLRTFSSN 160
Cdd:PRK15470  81 MQLKASTSGRDVYRRMGWSGEPTTSELKNPERNISMGAAYLNILETGPLAGIEDPKVLQYALVVSYANGAGALLRTFSSD 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 505178969 161 RQDAIDEINDLDADEFFEHVAKKHPAPQAPRYIWKLQKALDAM 203
Cdd:PRK15470 161 RKKAISKINDLDADEFLEHVARNHPAPQAPRYIYKLEQALDAM 203
 
Name Accession Description Interval E-value
emtA PRK15470
membrane-bound lytic murein transglycosylase EmtA;
1-203 2.46e-155

membrane-bound lytic murein transglycosylase EmtA;


Pssm-ID: 185367 [Multi-domain]  Cd Length: 203  Bit Score: 427.84  E-value: 2.46e-155
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505178969   1 MKLRWFVFLFVLLAGCSSKHDYTNPPWNPEVPVKRSMQWMPISEKAGAAWGVDPQLITAIIAIESGGNPSVVSKSGAVGL 80
Cdd:PRK15470   1 MKLRWFAFLIVLLAGCSSKHDYTNPPWNAKVPVQRAMQWMPISQKAGAAWGVDPQLITAIIAIESGGNPNAVSKSNAIGL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505178969  81 MQLKPSTSGRDVYQRMGWRGQPSVSELKNPERNISMGAAYLSILENGPLAGIKDPQVMRYAVVVSYANGAGALLRTFSSN 160
Cdd:PRK15470  81 MQLKASTSGRDVYRRMGWSGEPTTSELKNPERNISMGAAYLNILETGPLAGIEDPKVLQYALVVSYANGAGALLRTFSSD 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 505178969 161 RQDAIDEINDLDADEFFEHVAKKHPAPQAPRYIWKLQKALDAM 203
Cdd:PRK15470 161 RKKAISKINDLDADEFLEHVARNHPAPQAPRYIYKLEQALDAM 203
LT_MltC_MltE cd16893
membrane-bound lytic murein transglycosylases MltC and MltE, and similar proteins; MltC and ...
 41-199 1.85e-81

membrane-bound lytic murein transglycosylases MltC and MltE, and similar proteins; MltC and MltE are periplasmic, outer membrane attached lytic transglycosylases (LTs), which cleave beta-1,4-glycosidic bonds joining N-acetylmuramic acid and N-acetylglucosamine in the cell wall peptidoglycan, yielding 1,6-anhydromuropeptides. Proteins similar to this family include the soluble and insoluble membrane-bound LTs in bacteria and the LTs in bacteriophage lambda


Pssm-ID: 381614 [Multi-domain]  Cd Length: 162  Bit Score: 239.38  E-value: 1.85e-81
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505178969  41 PISEKAGAAWGVDPQLITAIIAIESGGNPSVVSKSGAVGLMQLKPSTSGRDVYQRMGWRGQ-PSVSELKNPERNISMGAA 119
Cdd:cd16893    1 PIVEKYAKKYGVDPALILAIIETESSFNPYAVSHSPAYGLMQIVPSTAGRDVYRLLGGKGGlPSKSYLFDPENNIDIGTA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505178969 120 YLSILENGPLAGIKDPQVMRYAVVVSYANGAGALLRTFSSNRQDAIDEINDLDADEFFEHVAKKHPAPQAPRYIWKLQKA 199
Cdd:cd16893   81 YLHILQNRYLKGIKNPKSREYCAIAAYNGGAGNVLRTFSSDRKKAISKINRLSPDEVYQHLTKKLPAAETRNYLKKVLKA 160
MltE COG0741
Soluble lytic murein transglycosylase or regulatory protein s ( may contain LysM/invasin ...
 23-195 5.11e-33

Soluble lytic murein transglycosylase or regulatory protein s ( may contain LysM/invasin domain) [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440504 [Multi-domain]  Cd Length: 244  Bit Score: 118.56  E-value: 5.11e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505178969  23 TNPPWNPEVPVKRSMQWMPISEKAGAAWGVDPQLITAIIAIESGGNPSVVSKSGAVGLMQLKPSTsGRDVYQRMGWRgqP 102
Cdd:COG0741   87 AELLALAALLLRRPLPYLPLIEEAAKKYGVDPALVLALIRQESAFNPNAVSPAGARGLMQLMPAT-ARRLGLKLGLG--P 163

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505178969 103 SVSELKNPERNISMGAAYLSILENGPLAGikdpqvmRYAVVVSYANGAGALLRTFSSNRQDAIDEIndldadeffehvak 182
Cdd:COG0741  164 SPDDLFDPETNIRAGAAYLRELLDRFDGD-------LVLALAAYNAGPGRVRRWLRRNGDRDGEII-------------- 222

                        170
                 ....*....|...
gi 505178969 183 khPAPQAPRYIWK 195
Cdd:COG0741  223 --PYAETRNYVKK 233
SLT pfam01464
Transglycosylase SLT domain; This family is distantly related to pfam00062. Members are found ...
 45-168 9.12e-33

Transglycosylase SLT domain; This family is distantly related to pfam00062. Members are found in phages, type II, type III and type IV secretion systems.


Pssm-ID: 396169 [Multi-domain]  Cd Length: 114  Bit Score: 113.94  E-value: 9.12e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505178969   45 KAGAAWGVDPQLITAIIAIESGGNPSVVSKSGAVGLMQLKPSTSGRDVYqrmgwRGQPSVSELKNPERNISMGAAYLSIL 124
Cdd:pfam01464   3 KAAQKYGVDPSLLLAIAQQESGFNPKAVSKSGAVGLMQIMPSTAKRLGL-----RVNPGVDDLFDPEKNIKAGTKYLKEL 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 505178969  125 ENGPLAGikdpqvmRYAVVVSYANGAGALLRTFSSNRQDAIDEI 168
Cdd:pfam01464  78 YKQYGGD-------LWLALAAYNAGPGRVRKWIKNAGAKDKKLL 114
 
Name Accession Description Interval E-value
emtA PRK15470
membrane-bound lytic murein transglycosylase EmtA;
1-203 2.46e-155

membrane-bound lytic murein transglycosylase EmtA;


Pssm-ID: 185367 [Multi-domain]  Cd Length: 203  Bit Score: 427.84  E-value: 2.46e-155
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505178969   1 MKLRWFVFLFVLLAGCSSKHDYTNPPWNPEVPVKRSMQWMPISEKAGAAWGVDPQLITAIIAIESGGNPSVVSKSGAVGL 80
Cdd:PRK15470   1 MKLRWFAFLIVLLAGCSSKHDYTNPPWNAKVPVQRAMQWMPISQKAGAAWGVDPQLITAIIAIESGGNPNAVSKSNAIGL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505178969  81 MQLKPSTSGRDVYQRMGWRGQPSVSELKNPERNISMGAAYLSILENGPLAGIKDPQVMRYAVVVSYANGAGALLRTFSSN 160
Cdd:PRK15470  81 MQLKASTSGRDVYRRMGWSGEPTTSELKNPERNISMGAAYLNILETGPLAGIEDPKVLQYALVVSYANGAGALLRTFSSD 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 505178969 161 RQDAIDEINDLDADEFFEHVAKKHPAPQAPRYIWKLQKALDAM 203
Cdd:PRK15470 161 RKKAISKINDLDADEFLEHVARNHPAPQAPRYIYKLEQALDAM 203
LT_MltC_MltE cd16893
membrane-bound lytic murein transglycosylases MltC and MltE, and similar proteins; MltC and ...
 41-199 1.85e-81

membrane-bound lytic murein transglycosylases MltC and MltE, and similar proteins; MltC and MltE are periplasmic, outer membrane attached lytic transglycosylases (LTs), which cleave beta-1,4-glycosidic bonds joining N-acetylmuramic acid and N-acetylglucosamine in the cell wall peptidoglycan, yielding 1,6-anhydromuropeptides. Proteins similar to this family include the soluble and insoluble membrane-bound LTs in bacteria and the LTs in bacteriophage lambda


Pssm-ID: 381614 [Multi-domain]  Cd Length: 162  Bit Score: 239.38  E-value: 1.85e-81
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505178969  41 PISEKAGAAWGVDPQLITAIIAIESGGNPSVVSKSGAVGLMQLKPSTSGRDVYQRMGWRGQ-PSVSELKNPERNISMGAA 119
Cdd:cd16893    1 PIVEKYAKKYGVDPALILAIIETESSFNPYAVSHSPAYGLMQIVPSTAGRDVYRLLGGKGGlPSKSYLFDPENNIDIGTA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505178969 120 YLSILENGPLAGIKDPQVMRYAVVVSYANGAGALLRTFSSNRQDAIDEINDLDADEFFEHVAKKHPAPQAPRYIWKLQKA 199
Cdd:cd16893   81 YLHILQNRYLKGIKNPKSREYCAIAAYNGGAGNVLRTFSSDRKKAISKINRLSPDEVYQHLTKKLPAAETRNYLKKVLKA 160
mltC PRK11671
membrane-bound lytic murein transglycosylase MltC;
34-199 1.66e-57

membrane-bound lytic murein transglycosylase MltC;


Pssm-ID: 183271 [Multi-domain]  Cd Length: 359  Bit Score: 184.87  E-value: 1.66e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505178969  34 KRSMQWMPISEKAGAAWGVDPQLITAIIAIESGGNPSVVSKSGAVGLMQLKPSTSGRDVYQRMGWRGQPSVSELKNPERN 113
Cdd:PRK11671 187 KRAHKYLPMVRKASRKYGVDESLILAIMQTESSFNPYAVSRSDALGLMQVVQHTAGKDVFRMKGKSGQPSRSYLFDPANN 266

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505178969 114 ISMGAAYLSILENGPLAGIKDPQVMRYAVVVSYANGAGALLRTFSSNRQDAIDEINDLDADEFFEHVAKKHPAPQAPRYI 193
Cdd:PRK11671 267 IDTGTAYLAILQNVYLGGITNPTSRRYAVITAYNGGAGSVLRVFSNDKIQAANIINTMSPGDVYQTLTTRHPSAESRRYL 346


                 ....*.
gi 505178969 194 WKLQKA 199
Cdd:PRK11671 347 YKVNTA 352
MltE COG0741
Soluble lytic murein transglycosylase or regulatory protein s ( may contain LysM/invasin ...
 23-195 5.11e-33

Soluble lytic murein transglycosylase or regulatory protein s ( may contain LysM/invasin domain) [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440504 [Multi-domain]  Cd Length: 244  Bit Score: 118.56  E-value: 5.11e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505178969  23 TNPPWNPEVPVKRSMQWMPISEKAGAAWGVDPQLITAIIAIESGGNPSVVSKSGAVGLMQLKPSTsGRDVYQRMGWRgqP 102
Cdd:COG0741   87 AELLALAALLLRRPLPYLPLIEEAAKKYGVDPALVLALIRQESAFNPNAVSPAGARGLMQLMPAT-ARRLGLKLGLG--P 163

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505178969 103 SVSELKNPERNISMGAAYLSILENGPLAGikdpqvmRYAVVVSYANGAGALLRTFSSNRQDAIDEIndldadeffehvak 182
Cdd:COG0741  164 SPDDLFDPETNIRAGAAYLRELLDRFDGD-------LVLALAAYNAGPGRVRRWLRRNGDRDGEII-------------- 222

                        170
                 ....*....|...
gi 505178969 183 khPAPQAPRYIWK 195
Cdd:COG0741  223 --PYAETRNYVKK 233
SLT pfam01464
Transglycosylase SLT domain; This family is distantly related to pfam00062. Members are found ...
 45-168 9.12e-33

Transglycosylase SLT domain; This family is distantly related to pfam00062. Members are found in phages, type II, type III and type IV secretion systems.


Pssm-ID: 396169 [Multi-domain]  Cd Length: 114  Bit Score: 113.94  E-value: 9.12e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505178969   45 KAGAAWGVDPQLITAIIAIESGGNPSVVSKSGAVGLMQLKPSTSGRDVYqrmgwRGQPSVSELKNPERNISMGAAYLSIL 124
Cdd:pfam01464   3 KAAQKYGVDPSLLLAIAQQESGFNPKAVSKSGAVGLMQIMPSTAKRLGL-----RVNPGVDDLFDPEKNIKAGTKYLKEL 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 505178969  125 ENGPLAGikdpqvmRYAVVVSYANGAGALLRTFSSNRQDAIDEI 168
Cdd:pfam01464  78 YKQYGGD-------LWLALAAYNAGPGRVRKWIKNAGAKDKKLL 114
LT_Slt70-like cd16896
uncharacterized lytic transglycosylase subfamily with similarity to Slt70; Uncharacterized ...
 44-126 7.32e-23

uncharacterized lytic transglycosylase subfamily with similarity to Slt70; Uncharacterized lytic transglycosylase (LT) with a conserved sequence pattern suggesting similarity to the Slt70, a 70kda soluble lytic transglycosylase which also has an N-terminal U-shaped U-domain and a linker L-domain. LTs catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue.


Pssm-ID: 381617 [Multi-domain]  Cd Length: 146  Bit Score: 89.49  E-value: 7.32e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505178969  44 EKAGAAWGVDPQLITAIIAIESGGNPSVVSKSGAVGLMQLKPSTsGRDVYQRMGWRGqPSVSELKNPERNISMGAAYLSI 123
Cdd:cd16896    9 EKYAKEYGVDPLLVAAVIKVESNFNPNAVSSKGAIGLMQIMPET-AEWIAEKLGLED-FSEDDLYDPETNIRLGTWYLSY 86


                 ...
gi 505178969 124 LEN 126
Cdd:cd16896   87 LLK 89
Slt70-like cd13401
70kDa soluble lytic transglycosylase (Slt70) and similar proteins; Catalytic domain of the ...
 37-122 3.95e-20

70kDa soluble lytic transglycosylase (Slt70) and similar proteins; Catalytic domain of the 70kda soluble lytic transglycosylase (LT)-like proteins, which also have an N-terminal U-shaped U-domain and a linker L-domain. LTs catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Proteins similar to this family include the soluble and insoluble membrane-bound LTs in bacteria and the LTs in bacteriophage lambda.


Pssm-ID: 381604 [Multi-domain]  Cd Length: 152  Bit Score: 82.52  E-value: 3.95e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505178969  37 MQWMPISEKAGAAWGVDPQLITAIIAIESGGNPSVVSKSGAVGLMQLKPSTsGRDVYQRMGWRGqPSVSELKNPERNISM 116
Cdd:cd13401    4 LPYRDLVERAAKKNGLDPALVYAIIRQESAFDPDAVSPAGALGLMQLMPAT-AKDVAKKLGLPY-YSPRDLFDPEYNIRL 81


                 ....*.
gi 505178969 117 GAAYLS 122
Cdd:cd13401   82 GSAYLA 87
LT-like cd00254
lytic transglycosylase(LT)-like domain; Members include the soluble and insoluble ...
 54-155 7.44e-19

lytic transglycosylase(LT)-like domain; Members include the soluble and insoluble membrane-bound LTs in bacteria and LTs in bacteriophage lambda. LTs catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue.


Pssm-ID: 381594 [Multi-domain]  Cd Length: 111  Bit Score: 78.02  E-value: 7.44e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505178969  54 PQLITAIIAIESGGNPSVVSKSGAVGLMQLKPSTsGRDVyqrmgwrGQPSVSELKNPERNISMGAAYLSIL---ENGPLa 130
Cdd:cd00254    1 PALVLAVIRVESGFNPRAVSPAGARGLMQLMPGT-ARDL-------GRRGVDDLFDPEENIRAGARYLRELldrFGGDL- 71

                         90       100
                 ....*....|....*....|....*
gi 505178969 131 gikdpqvmrYAVVVSYANGAGALLR 155
Cdd:cd00254   72 ---------ELALAAYNAGPGAVDR 87
MLTF-like cd13403
membrane-bound lytic murein transglycosylase F (MLTF) and similar proteins; This subfamily ...
 44-155 8.63e-18

membrane-bound lytic murein transglycosylase F (MLTF) and similar proteins; This subfamily includes membrane-bound lytic murein transglycosylase F (MltF, murein lyase F) that degrades murein glycan strands. It is responsible for catalyzing the release of 1,6-anhydromuropeptides from peptidoglycan. Lytic transglycosylase catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc) as do goose-type lysozymes. However, in addition, it also makes a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue.


Pssm-ID: 381606 [Multi-domain]  Cd Length: 161  Bit Score: 76.42  E-value: 8.63e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505178969  44 EKAGAAWGVDPQLITAIIAIESGGNPSVVSKSGAVGLMQLKPSTSgrdvyQRMGwrgqpsVSELKNPERNISMGAAYLSI 123
Cdd:cd13403    2 KKYAEKYGFDWRLLAAQAYQESRFNPNARSPAGARGLMQLMPSTA-----RELG------VNDRLDPEQNIHAGAKYLRY 70

                         90       100       110
                 ....*....|....*....|....*....|..
gi 505178969 124 LENGPLAGIKDPQVMRYAvVVSYANGAGALLR 155
Cdd:cd13403   71 LRDRFPPDIDEPDRLKFA-LAAYNAGPGHVRD 101
MltF COG4623
Membrane-bound lytic murein transglycosylase MltF [Cell wall/membrane/envelope biogenesis, ...
 34-121 1.16e-15

Membrane-bound lytic murein transglycosylase MltF [Cell wall/membrane/envelope biogenesis, Signal transduction mechanisms];


Pssm-ID: 443662 [Multi-domain]  Cd Length: 421  Bit Score: 74.33  E-value: 1.16e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505178969  34 KRSMQWMPISEKAGAAWGVDPQLITAIIAIESGGNPSVVSKSGAVGLMQLKPSTSgrdvyQRMGwrgqpsVSELKNPERN 113
Cdd:COG4623  259 GRLPPYDPLFEKYAEEYGLDWRLLAALAYQESHWNPRARSPTGARGLMQLMPATA-----KELG------VDDRLDPEQS 327


                 ....*...
gi 505178969 114 ISMGAAYL 121
Cdd:COG4623  328 IRAGAKYL 335
PRK11619 PRK11619
lytic murein transglycosylase; Provisional
 51-121 7.60e-08

lytic murein transglycosylase; Provisional


Pssm-ID: 183236 [Multi-domain]  Cd Length: 644  Bit Score: 51.60  E-value: 7.60e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 505178969  51 GVDPQLITAIIAIESGGNPSVVSKSGAVGLMQLKPSTSGRDVyQRMGWRGQPSVSELKNPERNISMGAAYL 121
Cdd:PRK11619 491 GIPQSYAMAIARQESAWNPKARSPVGASGLMQIMPGTATHTV-KMFSIPGYSSSSQLLDPETNINIGTSYL 560
Slt35-like cd13399
Slt35-like lytic transglycosylase; Lytic transglycosylase similar to Escherichia coli lytic ...
 50-87 8.44e-08

Slt35-like lytic transglycosylase; Lytic transglycosylase similar to Escherichia coli lytic transglycosylase Slt35 and Pseudomonas aeruginosa Sltb1. Lytic transglycosylase (LT) catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc) as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Proteins similar to this this family include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as the eukaryotic "goose-type" lysozymes (goose egg-white lysozyme; GEWL).


Pssm-ID: 381602 [Multi-domain]  Cd Length: 108  Bit Score: 48.46  E-value: 8.44e-08
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 505178969  50 WGVDPQLITAIIAIESGGNPS-VVSKSGAVGLMQLKPST 87
Cdd:cd13399    1 YGVPPGILAAILGVESGFGPNaGGSPAGAQGIAQFMPST 39
LT_IagB-like cd13400
Escherichia coli invasion protein IagB and similar proteins; Lytic transglycosylase-like ...
 50-122 1.06e-06

Escherichia coli invasion protein IagB and similar proteins; Lytic transglycosylase-like protein, similar to Escherichia coli invasion protein IagB. IagB is encoded within a pathogenicity island in Salmonella enterica and has been shown to degrade polymeric peptidoglycan. IagB-like invasion proteins are implicated in the invasion of eukaryotic host cells by bacteria. Lytic transglycosylase (LT) catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Members of this family resemble the soluble and insoluble membrane-bound LTs in bacteria and the LTs in bacteriophage lambda.


Pssm-ID: 381603 [Multi-domain]  Cd Length: 109  Bit Score: 45.60  E-value: 1.06e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 505178969  50 WGVDPQLITAIIAIESGGNPSVVSKSG----AVGLMQLkpSTSGRDVYQRMGWRGQpsvSELKNPERNISMGAAYLS 122
Cdd:cd13400    1 YGVPPRLLRAIAKVESGFNPNAINRNKngsyDIGLMQI--NSIWLPELARYGITRE---ELLNDPCTNIYVGAWILA 72
PRK10859 PRK10859
membrane-bound lytic murein transglycosylase MltF;
38-154 1.46e-06

membrane-bound lytic murein transglycosylase MltF;


Pssm-ID: 236778 [Multi-domain]  Cd Length: 482  Bit Score: 47.56  E-value: 1.46e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505178969  38 QWMPISEKAgaAWGVDPQLITAIIAIESGGNPSVVSKSGAVGLMQLKPSTSgrdvyQRMGwrgqpsVSELKNPERNISMG 117
Cdd:PRK10859 289 KYQPLFEKY--AGELDWRLLAAIAYQESHWNPQATSPTGVRGLMMLTRNTA-----QSMG------VTDRLDPEQSIRGG 355

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 505178969 118 AAYLS-ILENGPlAGIKDPQVMRYAvVVSYANGAGALL 154
Cdd:PRK10859 356 ARYLQdLMERLP-ESIPEPERIWFA-LAAYNIGYGHML 391
MltD-like cd16894
Membrane-bound lytic murein transglycosylase D and similar proteins; Lytic transglycosylases ...
 54-124 9.89e-06

Membrane-bound lytic murein transglycosylase D and similar proteins; Lytic transglycosylases (LT) catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc). Membrane-bound lytic murein transglycosylase D protein (MltD) family members may have one or more small LysM domains, which may contribute to peptidoglycan binding. Unlike the similar "goose-type" lysozymes, LTs also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Proteins similar to this family include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as the eukaryotic "goose-type" lysozymes (goose egg-white lysozyme; GEWL).


Pssm-ID: 381615 [Multi-domain]  Cd Length: 129  Bit Score: 43.28  E-value: 9.89e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 505178969  54 PQLITAIIAIESGGNPSVVSKSGAVGLMQLKPSTsGRDVYQRMGWrgqpSVSELKNPERNISMGAAYLSIL 124
Cdd:cd16894    7 PEELKYLALVESGFNPDAVSSAGAAGLWQFMPAT-AREYGLRVDS----WVDERRDPEKSTRAAARYLKDL 72
PHA00368 PHA00368
internal virion protein D
 42-124 6.51e-04

internal virion protein D


Pssm-ID: 222785 [Multi-domain]  Cd Length: 1315  Bit Score: 40.15  E-value: 6.51e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505178969   42 ISEKAGAAWGVDPQLITAIIAIESGGNPSVVSKSGAVGLMQLkpstsGRDVYQRMGWRGQPsvSELKNPERNISMGAAYL 121
Cdd:PHA00368   14 LFQKAADAHGVSYDLLRKVGWDESRFNPTAKSPTGPKGLMQF-----TKATAKALGLIVDD--DDRLDPELAIDAGARYL 86


                  ...
gi 505178969  122 SIL 124
Cdd:PHA00368   87 ADL 89
LT_TF-like cd13402
lytic transglycosylase-like domain of tail fiber-like proteins and similar domains; These tail ...
 56-87 1.58e-03

lytic transglycosylase-like domain of tail fiber-like proteins and similar domains; These tail fiber-like proteins are multi-domain proteins that include a lytic transglycosylase (LT) domain. Members of the LT family include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, and the eukaryotic "goose-type" lysozymes (goose egg-white lysozyme; GEWL). LTs catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue.


Pssm-ID: 381605 [Multi-domain]  Cd Length: 117  Bit Score: 36.79  E-value: 1.58e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 505178969  56 LITAIIAIESGGNPSVV------SKSG--AVGLMQLKPST 87
Cdd:cd13402    3 ALLRQIQTESGGNPNAInnwdsnAKAGhpSKGLMQVIPPT 42
Lyz-like cd00442
lysozyme-like domains; This family contains several members, including soluble lytic ...
 57-120 5.18e-03

lysozyme-like domains; This family contains several members, including soluble lytic transglycosylases (SLT), goose egg-white lysozymes (GEWL), hen egg-white lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, chitosanases, and pesticin. Typical members are involved in the hydrolysis of beta-1,4- linked polysaccharides.


Pssm-ID: 381596 [Multi-domain]  Cd Length: 59  Bit Score: 34.31  E-value: 5.18e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 505178969  57 ITAIIAIESGGNP--SVVSKSGAVGLMQLKPSTsgrdvyqrmgWR--GQPSVSELKNPERNISMGAAY 120
Cdd:cd00442    2 LAAIIGQESGGNKpaNAGSGSGAAGLFQFMPGT----------WKayGKNSSSDLNDPEASIEAAAKY 59
LT_VirB1-like cd16892
VirB1-like subfamily; This subfamily includes VirB1 protein, one of twelve proteins making up ...
 51-158 6.42e-03

VirB1-like subfamily; This subfamily includes VirB1 protein, one of twelve proteins making up type IV secretion systems (T4SS). T4SS are macromolecular assemblies generally composed of VirB1-11 and VirD4 proteins, and are used by bacteria to transport material across their membranes. VirB1 acts as a lytic transglycosylase (LT), and is important with respect to piercing the peptidoglycan layer in the periplasm. LTs catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc) as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Proteins similar to this family include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as the eukaryotic "goose-type" lysozymes (goose egg-white lysozyme; GEWL).


Pssm-ID: 381613 [Multi-domain]  Cd Length: 143  Bit Score: 35.60  E-value: 6.42e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505178969  51 GVDPQLITAIIAIESGGNPSVV------------SKSGAV---------------GLMQlkpstsgrdVYQR-MGWRGQp 102
Cdd:cd16892    8 GVHPETLAAIVQVESGGNPYAIgvnggklsrqpkTKAEAIatarqliaaghnfdvGLGQ---------INSRnLARLGL- 77

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 505178969 103 SVSELKNPERNISMGAAylsILENGplagikdpqvmrYAV-VVSYANGAGALLRTFS 158
Cdd:cd16892   78 TVEDVFDPCTNLKAGAT---ILTEC------------YARaKKTGGDGQAALRAALS 119
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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