|
Name |
Accession |
Description |
Interval |
E-value |
| PRK10642 |
PRK10642 |
proline/glycine betaine transporter ProP; |
10-499 |
0e+00 |
|
proline/glycine betaine transporter ProP;
Pssm-ID: 182611 [Multi-domain] Cd Length: 490 Bit Score: 993.83 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 10 ITLRDVTIIDDSKLRKAITAASLGNAMEWFDFGVYGFVAYALGKVFFPDADPSVQMIAALGTFSVPFLIRPLGGLFFGML 89
Cdd:PRK10642 1 ITLRDVTIIDDGKLRKAITAASLGNAMEWFDFGVYGFVAYALGKVFFPGADPSVQMIAALATFSVPFLIRPLGGLFFGML 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 90 GDKYGRQKILAITIVIMSISTFCIGLIPSYATIGIWAPILLLLCKMAQGFSVGGEYTGASIFVAEYSPDRKRGFMGSWLD 169
Cdd:PRK10642 81 GDKYGRQKILAITIVIMSISTFCIGLIPSYATIGIWAPILLLLCKMAQGFSVGGEYTGASIFVAEYSPDRKRGFMGSWLD 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 170 FGSIAGFVMGAGVVVLISSVVGEENFLDWGWRIPFFLALPLGIIGLYLRHALEETPAFQQHVDTLEQGDREGLQEGPKVS 249
Cdd:PRK10642 161 FGSIAGFVLGAGVVVLISTIVGEANFLDWGWRIPFFIALPLGIIGLYLRHALEETPAFQQHVDKLEQGDREGLQDGPKVS 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 250 FKEIATKHWRSLLTCIGLVISTNVTYYMLLTYMPSYLSHNLHYSEDHGVLIIIAIMVGMLFVQPVIGMLSDRFGRRPFIL 329
Cdd:PRK10642 241 FKEIATKHWRSLLTCIGLVIATNVTYYMLLTYMPSYLSHNLHYSEDHGVLIIIAIMIGMLFVQPVMGLLSDRFGRRPFVI 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 330 VGSVALFTLSIPAFIMINSNVIGLIFAGLLLLAVVLNCFIGVMASSLPAMFPTHIRFSALASAFNISVLIAGLTPTLAAW 409
Cdd:PRK10642 321 LGSVALFVLAIPAFILINSNVIGLIFAGLLMLAVILNCFTGVMASTLPAMFPTHIRYSALAAAFNISVLVAGLTPTLAAW 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 410 LVETTQNLMMPAYYLMVIAVIGLITGLSMKETANRPLKGATPAASDIQEAKEILGEHYDNIEHKIEDIDQEIADLQEKRA 489
Cdd:PRK10642 401 LVESTQNLMMPAYYLMVVAVIGLITGVTMKETANRPLKGATPAASDIQEAKEILVEHYDNIEQKIDDIDQEIAELQAKRT 480
|
490
....*....|
gi 505181589 490 RLVQQHPRIN 499
Cdd:PRK10642 481 RLVQQHPRID 490
|
|
| MFS_ProP |
cd17366 |
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This ... |
27-442 |
0e+00 |
|
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of Escherichia coli proline/betaine transporter, also called proline porter II (PPII), and similar proteins. ProP is a proton symporter that senses osmotic shifts and responds by importing osmolytes such as proline, glycine betaine, stachydrine, pipecolic acid, ectoine and taurine. It is both an osmosensor and an osmoregulator which is available to participate early in the bacterial osmoregulatory response. The ProP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340924 [Multi-domain] Cd Length: 377 Bit Score: 577.00 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 27 ITAASLGNAMEWFDFGVYGFVAYALGKVFFPDADPSVQMIAALGTFSVPFLIRPLGGLFFGMLGDKYGRQKILAITIVIM 106
Cdd:cd17366 1 VKAAALGNAMEWFDFGVYGYLAVTIGKVFFPGGDPTAQLLATFATFAVAFLVRPLGGLVFGPLGDKYGRQKVLAITIILM 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 107 SISTFCIGLIPSYATIGIWAPILLLLCKMAQGFSVGGEYTGASIFVAEYSPDRKRGFMGSWLDFGSIAGFVMGAGVVVLI 186
Cdd:cd17366 81 AASTFCIGLLPTYATIGVWAPILLLLARMVQGFSTGGEYGGAATFVAEYAPDRKRGFLGSWLEFGTLAGFILGAGLVTLL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 187 SSVVGEENFLDWGWRIPFFLALPLGIIGLYLRhaleetpafqqhvdtleqgdreglqegpkvsfkeiatkhwRSLLTCIG 266
Cdd:cd17366 161 TLLLTEAQMLDWGWRIPFLIAAPLGLVGLYLR----------------------------------------RPLLICIG 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 267 LVISTNVTYYMLLTYMPSYLSHNLHYSEDHGVLIIIAIMVGMLFVQPVIGMLSDRFGRRPFILVGSVALFTLSIPAFIMI 346
Cdd:cd17366 201 LVLVFNVTNYMLLSYMPSYLEETLGYSETHGLLVIIIIMVTMLVLQPFLGRLSDRVGRKPVYAAGLAGLLVLAVPAFLLM 280
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 347 NSNVIGLIFAGLLLLAVVLNCFIGVMASSLPAMFPTHIRFSALASAFNISVLIAGLTPTLAA-WLVETTQNLMMPAYYLM 425
Cdd:cd17366 281 NSGSIAAIFIGLLVLGLLLSCYTATMASTLPALFPTHVRYSALAIAFNISVSLFGGTTPLVAsWLVSATGNPLMPAYYLM 360
|
410
....*....|....*..
gi 505181589 426 VIAVIGLITGLSMKETA 442
Cdd:cd17366 361 VAAVVGLVAVLFLTETA 377
|
|
| 2A0106 |
TIGR00883 |
metabolite-proton symporter; This model represents the metabolite:H+ symport subfamily of the ... |
33-432 |
2.33e-157 |
|
metabolite-proton symporter; This model represents the metabolite:H+ symport subfamily of the major facilitator superfamily (pfam00083), including citrate-H+ symporters, dicarboxylate:H+ symporters, the proline/glycine-betaine transporter ProP, etc. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273320 [Multi-domain] Cd Length: 394 Bit Score: 452.50 E-value: 2.33e-157
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 33 GNAMEWFDFGVYGFVAYALGKVFFPDA-DPSVQMIAALGTFSVPFLIRPLGGLFFGMLGDKYGRQKILAITIVIMSISTF 111
Cdd:TIGR00883 1 GNAVEWFDFYLYGFAAVLVFHTFFPPSgDPLVALLATFATFAAGFLARPLGAIVFGHFGDRIGRKKTLVITLLMMGIGTL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 112 CIGLIPSYATIGIWAPILLLLCKMAQGFSVGGEYTGASIFVAEYSPDRKRGFMGSWLDFGSIAGFVMGAGVVVLISSVVG 191
Cdd:TIGR00883 81 LIGLLPSYATIGIWAPILLLLARLIQGFSLGGEWGGAALYLAEYAPPGKRGFYGSFQQVGAPVGLLLAALTVLLLSYLLG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 192 EENFLDWGWRIPFFLALPLGIIGLYLRHALEETPAFQQHVDTLEQgdreglqegPKVSFKEIATKHWRSLLTCIGLVIST 271
Cdd:TIGR00883 161 DDALLEWGWRIPFLVSAVLVLIGLYLRRNLEETPVFEKAQEKHKK---------KRGPIAETLTKHRKPFLLGLGLVIAT 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 272 NVTYYMLLTYMPSYLSHNLHYSEDHGVLIIIAIMVGMLFVQPVIGMLSDRFGRRPFILVGSVALFTLSIPAF-IMINSNV 350
Cdd:TIGR00883 232 TTTFYLITTYLPTYLTQTLGLSANSALLVLMLSLILFFITIPLSGALSDRIGRRPVLIIFTVLAALLAVPLLmALLDSGS 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 351 IGLIFAGLLLLAVVLNCFIGVMASSLPAMFPTHIRFSALASAFNISVLI-AGLTPTLAAWLVETTQNLMMPAYYLMVIAV 429
Cdd:TIGR00883 312 FTLFFFLVLGMALIGGMYTGPMGSFLPELFPTEVRYTGASLAYNLAGAIfGGFAPYIAAALVAMTGDWYAIGYYLAALAL 391
|
...
gi 505181589 430 IGL 432
Cdd:TIGR00883 392 IGL 394
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
24-436 |
5.14e-132 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 388.42 E-value: 5.14e-132
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 24 RKAITAASLGNAMEWFDFGVYGFVAyAL--GKVFFPDADPSVQMIAALGTFSVPFLIRPLGGLFFGMLGDKYGRQKILAI 101
Cdd:cd17369 1 RRVALASLVGTAIEWYDFFIYGTAA-ALvfNKLFFPAVDPAAGTLAAFATFGVGFLARPLGGVVFGHFGDRIGRKKTLVL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 102 TIVIMSISTFCIGLIPSYATIGIWAPILLLLCKMAQGFSVGGEYTGASIFVAEYSPDRKRGFMGSWLDFGSIAGFVMGAG 181
Cdd:cd17369 80 TLLLMGIATFLIGLLPTYAQIGILAPILLVLLRLLQGLALGGEWGGAVLMAVEHAPPKRRGFYGSFPQLGAPVGLLLATG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 182 VVVLISSVVGEENFLDWGWRIPFFLALPLGIIGLYLRHALEETPAFQQhvdTLEQGDReglqegPKVSFKEIATKHWRSL 261
Cdd:cd17369 160 VFLLLSALLSDEAFLSWGWRIPFLLSAVLVAVGLYIRLRLEETPVFRR---AKEAGQV------VRAPLVEVLRRHWRAL 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 262 LTCIGLVISTNVTYYMLLTYMPSYLSHNLHYSEDHGVLIIIAIMVGMLFVQPVIGMLSDRFGRRPFILVGSVALFTLSIP 341
Cdd:cd17369 231 LLAIGLRLAENVLFYLFTTFALSYATQTLGVDRSTVLLAVLIASVVAAITIPLFGWLSDRVGRRPVYLAGALLAALFAFP 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 342 AFIMINSNVIGLIFAGLLLLAVVLNCFI-GVMASSLPAMFPTHIRFSALASAFNI-SVLIAGLTPTLAAWLVETTQNLMM 419
Cdd:cd17369 311 FFWLLDTGSTWLIVLAAVVVLGVLHGMMyGPQAAFLAELFPTRVRYTGASLGYQLgAILGGGFAPLIATALVAATGSWWP 390
|
410
....*....|....*..
gi 505181589 420 PAYYLMVIAVIGLITGL 436
Cdd:cd17369 391 VALYLAALAVISLVAAL 407
|
|
| MFS_KgtP |
cd17367 |
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ... |
27-442 |
2.60e-101 |
|
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 310.00 E-value: 2.60e-101
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 27 ITAASLGNAMEWFDFGVYGFVAYALGKVFFPDADPSVQMIAALGTFSVPFLIRPLGGLFFGMLGDKYGRQKILAITIVIM 106
Cdd:cd17367 1 ILGGSVGNLVEWYDWYVYAAFALYFAPQFFPSGDPTVALLSTAAVFAVGFLMRPIGGWLFGRLADRIGRRAALTLSVSLM 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 107 SISTFCIGLIPSYATIGIWAPILLLLCKMAQGFSVGGEYTGASIFVAEYSPDRKRGFMGSWLDFGSIAGFVMGAGVVVLI 186
Cdd:cd17367 81 AAGSLVIAVTPTYATIGIWAPIILLLARLLQGLSVGGEYGTSATYLSEVAPPGRRGFYSSFQYVTLIGGQLLALGVLLVL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 187 SSVVGEENFLDWGWRIPFFLALPLGIIGLYLRHALEETPAFQQHVDTLEQgdreglqegPKVSFKEIAtKHWRSLLTCIG 266
Cdd:cd17367 161 QHTLGEDQMAAWGWRIPFLLGGVLAVVVLWLRRGLEETESFEAIAESNEA---------SAGTLRELR-RHPRELLLVVG 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 267 LVISTNVTYYMLLTYMPSYLSHNLHYSEDHGVLIIIAIMVGMLFVQPVIGMLSDRFGRRPFILVGSVA--LFTLSIPAFI 344
Cdd:cd17367 231 LTAGGTLAFYTWTTYLQKFLVNTAGFSKGDATWITTAALLVFMLLQPLGGRLSDRIGRRPLLLFFGIGgtLATVPLLSAL 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 345 MINSNVIGLiFAGLLLLAVVLNCFIGVMASSLPAMFPTHIRFSALASAFNISVLIAGLT-PTLAAWLVettQNLMMPAY- 422
Cdd:cd17367 311 DHTDSPYTA-FALVLVGLVFLSGYTSINAVVKAELFPTHVRALGVGLPYALAVAIFGGTaPYVALWLK---SIGHEWVFf 386
|
410 420
....*....|....*....|.
gi 505181589 423 -YLMVIAVIGLITGLSMKETA 442
Cdd:cd17367 387 wYVAGLIAISLVVYLRMPETR 407
|
|
| MFS_CitA |
cd17368 |
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton ... |
27-442 |
2.77e-99 |
|
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton symporter, also called citrate carrier protein or citrate transporter or citrate utilization protein A (CitA), is a proton symporter that functions in the uptake of citrate across the boundary membrane. It allows the utilization of citrate as a sole source of carbon and energy. In Klebsiella pneumoniae, the gene encoding this protein is called citH, instead of citA, which is the case for Escherichia coli and other organisms. CitA belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340926 [Multi-domain] Cd Length: 407 Bit Score: 304.68 E-value: 2.77e-99
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 27 ITAASLGNAMEWFDFGVYGFVAYALGKVFFPDADPSVQMIAALGTFSVPFLIRPLGGLFFGMLGDKYGRQKILAITIVIM 106
Cdd:cd17368 1 ILAATSGNALEFFDFGVYGFFAVYIGRLFFPSGSEFASLLLTFATFGVGFFMRPIGAIVLGAYADRIGRKPAMTLTLAIM 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 107 SISTFCIGLIPSYATIGIWAPILLLLCKMAQGFSVGGEYTGASIFVAEYSPDRKRGFMGSWLDFGSIAGFVMGAGVVVLI 186
Cdd:cd17368 81 ALGTLLIALAPTYATIGIAAPLLVLLARLLQGFAAGGEVGGVTAYLVEAAPPGRRGFYTSWQSASQQVAIVAGALVGYLL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 187 SSVVGEENFLDWGWRIPFFLALPLGIIGLYLRHALEETPAFQQHVDTLEqgdreglqegpKVSFKEIATKHWRSLLTCIG 266
Cdd:cd17368 161 SLTLTAEALAEWGWRIPFFIGLLIIPLGLWLRRSLEETEAFLERKARPT-----------RRELFALLANNRRIILLGML 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 267 LVISTNVTYYMLLTYMPSYLSHNLHYSEDHGVLIIIAIMVGMLFVQPVIGMLSDRFGRRPFILVGSVALFTLSIPAF-IM 345
Cdd:cd17368 230 LVAGSTVTFYFTTVYTPTYAKTVLGLSARDSFLVTLLAGVANFIWAPLGGALSDRIGRRPVLLVITLAALVTLYPVFaWL 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 346 INSNVIGLIFAGLLLLAVVLNCFIGVMASSLPAMFPTHIRFSALASAFNISVLI-AGLTPTLAAWLVETTQNLMMPAYYL 424
Cdd:cd17368 310 TAAPSFGRLLLVLLVLSFFFGMYGGAMVVALVELFPVRVRSTGFSLVYALAVAIfGGFAQFIVTWLIELTGSPLAPAWYL 389
|
410
....*....|....*...
gi 505181589 425 MVIAVIGLITGLSMKETA 442
Cdd:cd17368 390 MGAALLGLLATLMLRETA 407
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
27-436 |
4.49e-81 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 255.99 E-value: 4.49e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 27 ITAASLGNAMEWFDFGVYGFVAYALGKVFfpdaDPSVQMIAALGTFSVPFLIRPLGGLFFGMLGDKYGRQKILAITIVIM 106
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEF----SLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLF 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 107 SISTFCIGLIPSyatigiwaPILLLLCKMAQGFSVGGEYTGASIFVAEYSPDRKRGFMGSWLDFGSIAGFVMGAGVVVLI 186
Cdd:cd17316 77 GLATLLIGLLPT--------PILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLL 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 187 SSVVGEenflDWGWRIPFFLALPLGIIGLYLRhaleetpafqqhvdtleqgdreglqegpkvsfkeiatkhwRSLLTCIG 266
Cdd:cd17316 149 IPLLSG----DWGWRILFLIGALPALLALLLR----------------------------------------RRTLLLIL 184
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 267 LVISTNVTYYMLLTYMPSYLSHNLHYSEDHGVLIIIAIMVGMLFVQPVIGMLSDRFGRRPFILVGSVALFTLSIPAFIMI 346
Cdd:cd17316 185 LWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLL 264
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 347 NSNVIgLIFAGLLLLAVVLNCFIGVMASSLPAMFPTHIRFSALASAFNISVLIAGLTPTLAAWLVETTQNLMMPAYYLMV 426
Cdd:cd17316 265 SGSPT-LLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILAL 343
|
410
....*....|
gi 505181589 427 IAVIGLITGL 436
Cdd:cd17316 344 LAIVALIVAL 353
|
|
| PRK15075 |
PRK15075 |
tricarballylate/proton symporter TcuC; |
21-453 |
6.41e-78 |
|
tricarballylate/proton symporter TcuC;
Pssm-ID: 237902 [Multi-domain] Cd Length: 434 Bit Score: 250.63 E-value: 6.41e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 21 SKLRKAITAASlGNAMEWFDFGVYGFVAYALGKVFFPDADPSVQMIAALGTFSVPFLIRPLGGLFFGMLGDKYGRQKILA 100
Cdd:PRK15075 12 SKARAILRVTS-GNFLEMFDFFLFGFYATAIAKTFFPAGNEFASLMLTFAVFGAGFLMRPLGAIVLGAYIDRVGRRKGLI 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 101 ITIVIMSISTFCIGLIPSYATIGIWAPILLLLCKMAQGFSVGGEYTGASIFVAEYSPDRKRGFMGSWLDFGSIAGFVMGA 180
Cdd:PRK15075 91 VTLSIMASGTLLIAFVPGYATIGLAAPLLVLLGRLLQGFSAGVELGGVSVYLAEIATPGRKGFYTSWQSASQQVAVVFAA 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 181 GVVVLISSVVGEENFLDWGWRIPFF---LALPLgiiGLYLRHALEETPAFQQHvdtleqgdreglQEGPkvSFKEIAT-- 255
Cdd:PRK15075 171 LLGYLLNQWLSPAQMAEWGWRIPFLigcLIVPF---IFLIRRSLEETEEFLAR------------KHRP--SMREIFRsl 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 256 -KHWRSLLTCIGLVISTNVTYYMLLTYMPSYLSHNLHYSEDHGVLIIIAIMVGMLFVQPVIGMLSDRFGRRPFILVGSV- 333
Cdd:PRK15075 234 aANWRIVLAGMLMVAMTTVSFYLITVYTPTFGKTVLHLSAADSLLVTLCVGVSNFIWLPIGGALSDRIGRRPVLIAFTVl 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 334 ALFT--------LSIPAFIMINSNVIGLIFagllllavVLNCFIGVMASSLPAMFPTHIR---FS---ALASAfnisvLI 399
Cdd:PRK15075 314 AILTaypalswlVAAPSFARMLAVELWLSF--------LYGSYNGAMVVALTEVMPAEVRtagFSlaySLATA-----IF 380
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....
gi 505181589 400 AGLTPTLAAWLVETTQNLMMPAYYLMVIAVIGLITGLSMKETANRPLKGATPAA 453
Cdd:PRK15075 381 GGFTPAISTWLIHVTGDKAAPGYWLSFAAVCGLIATLVLYRRRGARLQAAEAAA 434
|
|
| PRK09952 |
PRK09952 |
shikimate transporter; Provisional |
21-441 |
1.29e-73 |
|
shikimate transporter; Provisional
Pssm-ID: 182163 [Multi-domain] Cd Length: 438 Bit Score: 239.25 E-value: 1.29e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 21 SKLRKAITAASLGNAMEWFDFGVYGFVAyAL--GKVFFPDADPSVQMIAALGTFSVPFLIRPLGGLFFGMLGDKYGRQKI 98
Cdd:PRK09952 18 SRARRAALGSFAGAVVDWYDFLLYGITA-ALvfNREFFPQVSPAMGTLAAFATFGVGFLFRPLGGVVFGHFGDRLGRKRM 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 99 LAITIVIMSISTFCIGLIPSYATIGIWAPILLLLCKMAQGFSVGGEYTGASIFVAEYSPDRKRGFMGSWLDFGSIAGFVM 178
Cdd:PRK09952 97 LMLTVWMMGIATALIGLLPSFSTIGWWAPVLLVTLRAIQGFAVGGEWGGAALLAVESAPKNKKAFYSSGVQVGYGVGLLL 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 179 GAGVVVLISSVVGEENFLDWGWRIPFFLALPLGIIGLYLRHALEETPAFQQHVdtleqgdREGLQEGPKVSFKEIATKHW 258
Cdd:PRK09952 177 STGLVSLISMMTTDEQFLSWGWRIPFLFSIVLVLIALWVRNGMEESAEFEQQQ-------HEQAAAKKRIPVIEALLRHP 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 259 RSLLTCIGLVISTNVTYYMLLTYMPSYLSHNLHYSEDhgVLIIIAIMVGML--FVQPVIGMLSDRFGRRPFILVGSVALF 336
Cdd:PRK09952 250 GAFLKIIALRLCELLTMYIVTAFALNYSTQNLGLPRE--LFLNIGLLVGGLscLTIPCFAWLADRFGRRRVYITGALIGT 327
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 337 TLSIPAFIMINS-NVIGLIFAGLLLLAVVLNCFIGVMASSLPAMFPTHIRFSALASAFNI-SVLIAGLTPTLAAWLVETT 414
Cdd:PRK09952 328 LSAFPFFMALEAqSIFWIVFFSIMLANIAHDMVVCVQQPMFTEMFGASYRYSGAGVGYQVaSVVGGGFTPFIAAALVTYF 407
|
410 420
....*....|....*....|....*...
gi 505181589 415 Q-NLMMPAYYLMVIAVIGLITGLSMKET 441
Cdd:PRK09952 408 GgSWHSVAIYLLAGCLISAMTALLMKDN 435
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
30-447 |
5.89e-72 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 235.63 E-value: 5.89e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 30 ASLGNAMEWFDFGVYGFVAYALGKVFFPDADPSVQMIAALG-----TFSVPFLIRPLGGLFFGMLGDKYGRQKILAITIV 104
Cdd:pfam00083 5 AALGGFLFGYDTGVIGAFLTLIDFFKNFGLSKSVSSLAALSvlsglIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANV 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 105 IMSISTFCIGLIPSYatigiWAPILLLLCKMAQGFSVGGEYTGASIFVAEYSPDRKRGFMGSWLDFGSIAGFVMGAGVVV 184
Cdd:pfam00083 85 LFVIGAVLQGAAKGK-----WSVYQLIVGRVLVGIGVGGASVLAPMYISEIAPKKLRGALGSLYQLAITFGILLAYIFGL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 185 LISSVVGEenfldWGWRIPFFLALPLGIIGLYLRHALEETPAFQQHVDTLEQgDREGLQ-----EGPKVSFKEIATKHWR 259
Cdd:pfam00083 160 GLNKTSNS-----DGWRIPLGLQLVPALLLIIGLLFLPESPRWLVEKGRLEE-AREVLAklrgvPDVDRELDEIKDSLEA 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 260 S--------------------LLTCIGLVISTNVTYYMLLTYMPSYLSHNLHYSEDhgvLIIIAIMVGMLFVQPVIG-ML 318
Cdd:pfam00083 234 GqeaekaswkelfstktrrqrLLIGVMLQIFQQLTGINAIFYYSTTIFENLGLSDS---FLVTIIVGVVNFVFTFIAiFL 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 319 SDRFGRRPFILVG----SVALFTLSIPAFIMIN---SNVIGLIFAGLLLLAVVLNCFIGVMASSLPAMFPTHIRFSALAS 391
Cdd:pfam00083 311 VDRFGRRPLLLLGaagmAICFVILGIVALLGVSksdWAGIVAIVFIALFIAFFAMGWGPVPWVIVSELFPLSVRSKAMAL 390
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*.
gi 505181589 392 AFNISVLIAGLTPTLAAWLVETTQNLMMPAYYLMVIAVIGLITGLSMKETANRPLK 447
Cdd:pfam00083 391 ATAANWLANFLIGFLFPIITDAIGLGYTFFIFAGLLVLFIIFVFFFVPETKGRTLE 446
|
|
| PRK10406 |
PRK10406 |
alpha-ketoglutarate transporter; Provisional |
26-340 |
3.47e-64 |
|
alpha-ketoglutarate transporter; Provisional
Pssm-ID: 182433 [Multi-domain] Cd Length: 432 Bit Score: 214.67 E-value: 3.47e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 26 AITAASLGNAMEWFDFGVYGFVAYALGKVFFPDADPSVQMIAALGTFSVPFLIRPLGGLFFGMLGDKYGRQKILAITIVI 105
Cdd:PRK10406 23 AIVGASSGNLVEWFDFYVYSFCSLYFAHIFFPSGNTTTQLLQTAGVFAAGFLMRPIGGWLFGRIADKHGRKKSMLISVCM 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 106 MSISTFCIGLIPSYATIGIWAPILLLLCKMAQGFSVGGEYTGASIFVAEYSPDRKRGFMGSWLDFGSIAGFVMGAGVVVL 185
Cdd:PRK10406 103 MCFGSLVIACLPGYETIGTWAPALLLLARLFQGLSVGGEYGTSATYMSEVAVEGRKGFYASFQYVTLIGGQLLALLVVVV 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 186 ISSVVGEENFLDWGWRIPFFLALPLGIIGLYLRHALEETPAfQQHVDTLEQGDREGLQegpkvsfkeiatKHWRSLLTCI 265
Cdd:PRK10406 183 LQQTLEDAELREWGWRIPFALGAVLAVVALWLRRQLDETSQ-QETRALKEAGSLKGLW------------RNRRAFIMVL 249
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 505181589 266 GLVISTNVTYYMLLTYMPSYL--SHNLHYSEDHGvLIIIAIMVGMLfVQPVIGMLSDRFGRRPFILV--GSVALFTLSI 340
Cdd:PRK10406 250 GFTAAGSLCFYTFTTYMQKYLvnTAGMHANVASG-IMTAALFVFML-IQPLIGALSDKIGRRTSMLCfgSLAALFTVPI 326
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
29-441 |
1.03e-37 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 142.44 E-value: 1.03e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 29 AASLGNAMEWFDFGVYGFVAYALGKVFFPDAdpsvqmIAALGTFSVPFLIRPLGGLFFGMLGDKYGRQKILAITIVIMSI 108
Cdd:cd17371 3 AAFLGWALDGFDLLLLGLVLPALIAEFGLDE------AEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAV 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 109 STFCIGLIPSYatigiwapILLLLCKMAQGFSVGGEYTGASIFVAEYSPDRKRGFMGSWLDfgsiAGFVMGAGVVVLISS 188
Cdd:cd17371 77 FTLLCGFAQNY--------WQLLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQ----SGWAVGWLLATLLAA 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 189 VVGEENFLDWGWRIPFFLALPLGIIGLYLRHALEETPAFQQHvdtleqgDREGLQEGPKVSFKEIATKHWRSL-LTCIGL 267
Cdd:cd17371 145 LLFPLLPPEIAWRVLFLLGALPALLVLFIRRFVKEPPQWQAA-------RAARRHFADRPSLRELFSPPLLRTtLLASLL 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 268 VISTNVTYYMLLTYMPSYLSHNLHYSeDHGVLIIIAIMV-GMLFVQPVIGMLSDRFGRRPFILVGSV--ALFTLSIPAFI 344
Cdd:cd17371 218 ATGALGGYYGITTWLPSYLTGERGLS-FEGSAGYLVVTIlGGFLGYLAGGFLADRIGRRNNFALFALgsAISILLYFFLP 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 345 MINSNVIGLIFAGLLLLAVVlncfIGVMASSLPAMFPTHIRFSALASAFNISVLIAGLTPTLAAWLveTTQNLMMPAYYL 424
Cdd:cd17371 297 LSPTLILILGFPLGFFASGP----FSGMGAYLTELFPTAVRATAQGFCYNVGRIIGALFPFLVGFL--ATSGSLGTAIAV 370
|
410
....*....|....*....
gi 505181589 425 MVIA--VIGLITGLSMKET 441
Cdd:cd17371 371 FAAVyyIAGLVLALLLPET 389
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
24-433 |
3.19e-35 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 135.00 E-value: 3.19e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 24 RKAITAASLGNAMEWFDFGVYGFVAYALGKVFFPDAdpsvqmiAALGT-FSVPFLIRPLGGLFFGMLGDKYGRQKILAIT 102
Cdd:COG2271 9 WRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSA-------AQLGLlASAFFLGYALGQIPAGLLADRFGRRRVLAIG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 103 IVIMSISTFCIGLIPSYAtigiwapiLLLLCKMAQGFSVGGEYTGASIFVAEYSPDRKRGFMGSWLDFGSIAGFVMGAGV 182
Cdd:COG2271 82 LLLWGLATLLFGFATSFW--------QLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPL 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 183 VVLISSVvgeenfldWGWRIPFFLALPLGIIGLYLRhaleetpafqqhvdtleqgdreglqegpkvsfkeiatkhwrsLL 262
Cdd:COG2271 154 LGWLLAA--------FGWRAAFLILGLPGLLLALLR------------------------------------------FW 183
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 263 TCIGLVISTNVTYYMLLTYMPSYLSHNLHYSEDHGVLIIIAIMVGMLFVQPVIGMLSDRFGRRP-FILVGSVALFTLSIP 341
Cdd:COG2271 184 LLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRkLVLAIGLLLAALALL 263
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 342 AFIMINSNVIGLIFagLLLLAVVLNCFIGVMASSLPAMFPTHIRFSALASAFNISVLIAGLTPTLAAWLVETTqNLMMPA 421
Cdd:COG2271 264 LLALLPSPALAIAL--LFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDAT-GYQAAF 340
|
410
....*....|..
gi 505181589 422 YYLMVIAVIGLI 433
Cdd:COG2271 341 LLLAALALLAAL 352
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
24-445 |
5.62e-35 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 135.01 E-value: 5.62e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 24 RKAITAASLGNAMEWFDFGVYGFVAYALGKVFfpDADPSVQMIAalgtFSVPFLIRPLGGLFFGMLGDKYGRQKILAITI 103
Cdd:COG2223 4 WRVLLLATLAFFLAFGVWYLWSVLAPPLAEEF--GLSAAQLGLL----FAIPVLVGALLRIPLGFLVDRFGPRRVLLIGL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 104 VIMSISTFCIGLIPSYatigiwapILLLLCKMAQGFSVGGEYTGASIFVAEYSPDRKRGFMGSWLdfgsIAGFVMGAGVV 183
Cdd:COG2223 78 LLLGIGLLLLALAVSY--------WLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLA----AGGGNLGAAVA 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 184 VLISSVVgeenFLDWGWRIPFFL-ALPLGIIGLYLRHALEETPafqqhvdtleqgdrEGLQEGPKVSFKEI--ATKHWRS 260
Cdd:COG2223 146 AFLAPLL----IAAFGWRNAFLIlGILLLVVAVLAWLFLRDPP--------------AGAAAAAKASLRDQleALRDPRF 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 261 LLTCIGLVISTnVTYYMLLTYMPSYLSHNLHYSEDHGVLIIIAIMVGMLFVQPVIGMLSDRFGRRP-FILVGSVALFTLS 339
Cdd:COG2223 208 WLLSLLYFGTF-GSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRvLLIVFALMALGLL 286
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 340 IPAFIMINSNVIGLIFAGLLLLAVVLNcfiGVMASSLPAMFPTHIRFSALASAFNISVLIAGLTPTLAAWLVETTQNLMM 419
Cdd:COG2223 287 LLALALGSLWLFLVLFLLLGLALGGGN---GAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTA 363
|
410 420
....*....|....*....|....*.
gi 505181589 420 PAYYLMVIAVIGLITGLSMKETANRP 445
Cdd:COG2223 364 AFLVFAVLALVALVLTLLLYRRPRRA 389
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
24-401 |
1.61e-34 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 132.79 E-value: 1.61e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 24 RKAITAASLGNAMEWFDFGVYGFVAYALGKVFfpdaDPSVQMIAALgtFSVPFLIRPLGGLFFGMLGDKYGRQKILAITI 103
Cdd:COG2814 9 WLALLALALGAFLSGLGIGIVLPALPLIAADL----GASPAQAGLV--VTAYLLGAALGAPLAGRLADRFGRRRVLLLGL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 104 VIMSISTFCIGLIPSYAtigiwapiLLLLCKMAQGFSVGGEYTGASIFVAEYSPDRKRGFMGSWLDFGSIAGFVMGAGVV 183
Cdd:COG2814 83 LLFALGSLLCALAPSLW--------LLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLG 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 184 VLISSVvgeenfldWGWRIPFFLALPLGIIGLYLRH-ALEETPAFQqhvdtleqgdREGLQEGPKVSFKeiatkhWRSLL 262
Cdd:COG2814 155 GLLADL--------FGWRWVFLVNAVLALLALLLLLrLLPESRPAA----------RARLRGSLRELLR------RPRLL 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 263 TCIGLVISTNVTYYMLLTYMPSYLSHNLHYSEDHGVLIIIAIMVGMLFVQPVIGMLSDRFGRRPFILVGSVALFtlsIPA 342
Cdd:COG2814 211 LLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLA---LGL 287
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 505181589 343 FIMINSNVIGLIFAGLLLLAVVLNCFIGVMASSLPAMFPTHIRfsALASAFNISVLIAG 401
Cdd:COG2814 288 LLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEAR--GRASGLYNSAFFLG 344
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
24-227 |
1.05e-33 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 129.16 E-value: 1.05e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 24 RKAITAASLGNAMEWFDFGVYGFVAYALGKVFFPDAdPSVQMIAALGtfsvpFLIRPLGGLFFGMLGDKYGRQKILAITI 103
Cdd:COG0477 13 RRALLALALGTFLEGLDFTIVNVALPSIAADLGASS-AQLGWIVSAY-----LLGRAIGLLLFGRLGDRYGRKRVLLIGL 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 104 VIMSISTFCIGLIPSyatigiwaPILLLLCKMAQGFSVGGEYTGASIFVAEYSPDRKRGFMGSWLDFGSIAGFVMGAGVV 183
Cdd:COG0477 87 LLFGLASLLCGLAPS--------PELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLG 158
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 505181589 184 VLISSVvgeenfldWGWRIPFFLALPLGIIGLYLRHALEETPAF 227
Cdd:COG0477 159 GLLVAA--------LGWRWIFLINAPLGLLALVLRLRLPESRGL 194
|
|
| Osmo_CC |
pfam08946 |
Osmosensory transporter coiled coil; The osmosensory transporter coiled coil is a C-terminal ... |
454-498 |
1.66e-24 |
|
Osmosensory transporter coiled coil; The osmosensory transporter coiled coil is a C-terminal domain found in various bacterial osmoprotective transporters, such as ProP, Proline/betaine transporter, Proline permease 2 and the citrate proton symporters. It adopts an antiparallel coiled-coil structure, and is essential for osmosensory and osmoprotectant transporter function.
Pssm-ID: 430338 Cd Length: 45 Bit Score: 95.52 E-value: 1.66e-24
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 505181589 454 SDIQEAKEILGEHYDNIEHKIEDIDQEIADLQEKRARLVQQHPRI 498
Cdd:pfam08946 1 SDRQEAKELLQEHYDNIEQKIEDIDEEIAALEEKRQRLVDQHPHI 45
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
72-348 |
8.31e-24 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 102.65 E-value: 8.31e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 72 FSVPFLIRPLGGLFFGMLGDKYGRQKILAITIVIMSISTFCIGLIPSYAtigiwapiLLLLCKMAQGFSVGGEYTGASIF 151
Cdd:cd17325 37 VAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYW--------QLLLARFLQGLASAAVWPAAMAL 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 152 VAEYSPDRKRGFMGSWLDFGSIAGFVMGAGVVVLISSVvgeenfldWGWRIPFFLALPLGIIGLYLRHA-LEETPAFQQH 230
Cdd:cd17325 109 IADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADA--------LGYRAPFLVCAALALLALVLALLlLPEPRPPPNK 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 231 VDTLEQGDREGLQEgpkvsfkeiaTKHWRSLLTCIGLVISTNVTYYMLLTYMPSYLSHNLHYSEDHGVLIIIAIMVGMLF 310
Cdd:cd17325 181 RAVSAARLRSGLRL----------LLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASAL 250
|
250 260 270
....*....|....*....|....*....|....*...
gi 505181589 311 VQPVIGMLSDRFGRRPFILVGSVaLFTLSIPAFIMINS 348
Cdd:cd17325 251 SQPPAGKLSDRIGRKPLILIGLL-LSAVALLLLPLATS 287
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
17-411 |
1.95e-23 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 102.05 E-value: 1.95e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 17 IIDDSKLR----KAITAASLGNAMEWFDFGVYGFVAYALGKVFfpDADP-SVQMIAALGTFSVPFlirplGGLFFGMLGD 91
Cdd:TIGR00895 5 NIRKQPLSryqwRAIILSFLIMLMDGYDLAAMGFAAPAISAEW--GLDPvQLGFLFSAGLIGMAF-----GALFFGPLAD 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 92 KYGRQKILAITIVIMSISTFCIGLIPSYatigiwaPILLLLCKMAqGFSVGGEYTGASIFVAEYSPDRKRGFMGSWLdfg 171
Cdd:TIGR00895 78 RIGRRRVLLWSILLFSVFTLLCALATNV-------TQLLILRFLA-GLGLGGLMPNLNALVSEYAPKRFRGTAVGLM--- 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 172 sIAGFVMGAGVVVLISSVVGEenflDWGWRIPFFLA--LPLgIIGLYLRHALEETPAFQQ-------------HVDTLEQ 236
Cdd:TIGR00895 147 -FCGYPIGAAVGGFLAGWLIP----VFGWRSLFYVGgiAPL-LLLLLLMRFLPESIDFLVskrpetvrrivnaIAPQMQA 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 237 GDREGLQEGP------KVSFKEI-ATKHWRSLLTCIGLVISTNVTYYMLLTYMPsYLSHNLHYSEDHGVLIIIAIMVGML 309
Cdd:TIGR00895 221 EAQSALPEQKstqgtkRSVFKALfQGKTARITVLLWLLYFMLLVGVYFLTNWLP-KLMVELGFSLSLAATGGALFNFGGV 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 310 FVQPVIGMLSDRFGRRP---FILVGSVALFTLSIPAFIMINSNVIGLIFagllllAVVLNCFIGVMASSLPAMFPTHIRF 386
Cdd:TIGR00895 300 IGSIIFGWLADRLGPRVtalLLLLGAVFAVLVGSTLFSPTLLLLLGAIA------GFFVNGGQSGLYALMALFYPTAIRA 373
|
410 420
....*....|....*....|....*
gi 505181589 387 SALASAFNISVLIAGLTPTLAAWLV 411
Cdd:TIGR00895 374 TGVGWAIGIGRLGAIIGPILAGYLL 398
|
|
| PRK03893 |
PRK03893 |
putative sialic acid transporter; Provisional |
24-414 |
8.65e-23 |
|
putative sialic acid transporter; Provisional
Pssm-ID: 179668 [Multi-domain] Cd Length: 496 Bit Score: 101.31 E-value: 8.65e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 24 RKAITAASLGNAMEWFDFGVYGFVAYALGKVFfpdadpSVQMIAALGTFSVPFLIRPLGGLFFGMLGDKYGRQKILAITI 103
Cdd:PRK03893 19 WKAFSAAWLGYLLDGFDFVLITLVLTEVQGEF------GLTTVQAASLISAAFISRWFGGLLLGAMGDRYGRRLAMVISI 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 104 VIMSISTFCIGLIPSYATigiwapilLLLCKMAQGFSVGGEYTGASIFVAEYSPDRKRGFMGSWLdfgsIAGFVMGAGVV 183
Cdd:PRK03893 93 VLFSVGTLACGFAPGYWT--------LFIARLVIGMGMAGEYGSSATYVIESWPKHLRNKASGFL----ISGFSIGAVVA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 184 VLISSVVGEEnfldWGWRIPFFLALPLGIIGLYLRHALEETPAFQQH----------VDTLEQGDR-------------- 239
Cdd:PRK03893 161 AQVYSLVVPV----WGWRALFFIGILPIIFALWLRKNLPEAEDWKEKhagkapvrtmVDILYRGEHriinilltlaaaaa 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 240 ------EGLQEGPKV------------SF-KEIATKHWRSLLTCIGLVISTNVTYYMLLTYMPSYLSHNLHYSEDHGVLI 300
Cdd:PRK03893 237 lwfcfaGNLQNAAIVavlgllcaaifiSFmVQSSGKRWPTGVMLMVVVLFAFLYSWPIQALLPTYLKTDLGYDPHTVANV 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 301 IIAIMVGMLFVQPVIGMLSDRFGRRPFILVGSVALFTLSIPAFIMINSNVI---GLIFAGLLLLAVVLncfiGVMASSLP 377
Cdd:PRK03893 317 LFFSGFGAAVGCCVGGFLGDWLGTRKAYVCSLLISQLLIIPVFAIGGANVWvlgLLLFFQQMLGQGIS----GLLPKLIG 392
|
410 420 430
....*....|....*....|....*....|....*..
gi 505181589 378 AMFPTHIRFSALASAFNISVLIAGLTPTLAAWLVETT 414
Cdd:PRK03893 393 GYFDTEQRAAGLGFTYNVGALGGALAPILGALIAQRL 429
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
38-404 |
6.41e-22 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 96.72 E-value: 6.41e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 38 WFDFGVYGFVAYALGKVFFPDADPSVQMIAALgtFSVPFLIRPLGGLFFGMLGDKYGRQKILAITIVIMSISTFCIGLIP 117
Cdd:pfam07690 6 FLAALGRSLLGPALPLLLAEDLGISPTEIGLL--LTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFAS 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 118 SYAtigiwapiLLLLCKMAQGFSVGGEYTGASIFVAEYSPDRKRGFMGSWLDFGSIAGFVMGAGVVVLISSVvgeenfld 197
Cdd:pfam07690 84 SLW--------LLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASL-------- 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 198 WGWRIPFFLALPLGIIGLYLRHALEETPafqqhvDTLEQGDREGLQEGPKVSFKEIATKHWRSLLTCIglvISTNVTYYM 277
Cdd:pfam07690 148 FGWRAAFLILAILSLLAAVLLLLPRPPP------ESKRPKPAEEARLSLIVAWKALLRDPVLWLLLAL---LLFGFAFFG 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 278 LLTYMPSYLSHnLHYSEDHGVLIIIAIMVGMLFVQPVIGMLSDRFGRRPFILVGSVALFTLSIPAFIMINSNVIGLIFAG 357
Cdd:pfam07690 219 LLTYLPLYQEV-LGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLA 297
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 505181589 358 LLLLAVVLNCFIGVMASSLPAMFPTHIRFSALASAFNISVLIAGLTP 404
Cdd:pfam07690 298 LLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| PRK12307 |
PRK12307 |
MFS transporter; |
24-438 |
9.84e-20 |
|
MFS transporter;
Pssm-ID: 237051 [Multi-domain] Cd Length: 426 Bit Score: 91.53 E-value: 9.84e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 24 RKAITAASLGNAMEWFDFGVYGFVAYALgkvffpDADPSVQMIAALGTFSVPFLIRPLGGLFFGMLGDKYGRQKILAITI 103
Cdd:PRK12307 17 KNALFSAWLGYVFDGFDFMLIFYIMYLI------KADLGLTDMEGAFLATAAFIGRPFGGALFGLLADKFGRKPLMMWSI 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 104 VIMSISTFCIGLIPSYatigiwapILLLLCKMAQGFSVGGEYTGASIFVAEYSPDRKRGFMGSWLdfgsIAGFVMGAGVV 183
Cdd:PRK12307 91 VAYSVGTGLSGLASGV--------IMLTLSRFIVGMGMAGEYACASTYAVESWPKHLKSKASAFL----VSGFGIGNIIA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 184 VLISSVVGEEnfldWGWRIPFFLALPLGIIGLYLRHALEETPAFQQHVDTLEQGDREGLQEGPKVSFKEIATKHWRSLLT 263
Cdd:PRK12307 159 AYFMPSFAEA----YGWRAAFFVGLLPVLLVIYIRARAPESKEWEEAKLSGKGKHSQSAWSVFSLSMKGLFNRAQFPLTL 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 264 CIGLVI-STNVTYYMLLTYMPSYLSHNlhySEDHGVL--IIIAIMVGMLFVQPVIGMLSDRFGRRPFILVGSVALFTLSI 340
Cdd:PRK12307 235 CVFIVLfSIFGANWPIFGLLPTYLAGE---GFDTGVVsnLMTAAAFGTVLGNIVWGLCADRIGLKKTFSIGLLMSFLFIF 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 341 PAFIMI--NSNVIGLifagllllavvlnCFIGVMASSLPA----------MFPTHIRFSALASAFNISVLIAGLTPTLAA 408
Cdd:PRK12307 312 PLFRIPqdNYLLLGA-------------CLFGLMATNVGVgglvpkflydYFPLEVRGLGTGLIYNLAATSGTFNSMAAT 378
|
410 420 430
....*....|....*....|....*....|..
gi 505181589 409 WLvETTQNLMMPAYYLMVI--AVIGLITGLSM 438
Cdd:PRK12307 379 WL-GITMGLGAALTFIVAFwtATILLIIGLSI 409
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
81-436 |
3.05e-18 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 86.06 E-value: 3.05e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 81 LGGLFFGMLGDKYGRQKILAITIVIMSISTFCIGLIPSYAtigiwapiLLLLCKMAQGFSVGGEYTGASIFVAEYSPDRK 160
Cdd:cd17324 49 LGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFA--------LLLLARALAGLAHGGFWAIAAAYAADLVPPEK 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 161 RGF-MGSWldfgsIAGFVMGAGVVVLISSVVGEEnfldWGWRIPFFLALPLGIIG-LYLRHALEETPAFQqhvdtleqgd 238
Cdd:cd17324 121 RGRaIGLV-----FSGLTLGLVLGRPLGGLLGQL----LGWRAAFLAIAVLALLAaLLLWRLLPSLPPKK---------- 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 239 reglqEGPKVSFKEIAtKHWRS--LLTCIGLVISTNVTYYMLLTYMPSYLSHNLHYSEDHGVLIIIAIMVGMLFVQPVIG 316
Cdd:cd17324 182 -----PGSLGLLSSLL-LLLRNprLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAG 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 317 MLSDRFGRRPFILVGsvALFTLSIPAFIMINSNVIGLIfagllllavVLNCFIGVMASSLPAMFPTHI-----RFSALAS 391
Cdd:cd17324 256 RLADRGGRRALLIAL--LLLAAALLLLTLLGPSPLLLL---------VGLVLWGLGFFAAHSALQTRVlrlapEARGLAS 324
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 505181589 392 AFNISVLIAGLT--PTLAAWLVETTQnLMMPAYYLMVIAVIGLITGL 436
Cdd:cd17324 325 SLYLAAYNLGGAlgAALGGLVLDHGG-WAGVGWVGAALLLLALLLAL 370
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
30-433 |
1.23e-17 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 84.40 E-value: 1.23e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 30 ASLGNAMEWFDFGVYGFVAYALGKVFfpDADPSVQMIAalgtFSVPFLIRPLGGLFFGMLGDKYGRQKILAITIVIMSIS 109
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSF--GLSASQLGLL----FALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALG 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 110 TFCIGLIPSYatigiwapILLLLCKMAQGFSVGGEYTGASIFVAEYSPDRKRGFMGSWLDFGSIAGFVMGAGVVVLISSv 189
Cdd:cd06174 75 ALLFAFAPSF--------WLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILAS- 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 190 vgeenFLDWGWRIPFFLALPLGIIGLYLRHALEETPAFQQhvdtleqgdREGLQEGPKVSFKEIATKHWRSLLTCIGLVI 269
Cdd:cd06174 146 -----SLGFGWRAVFLIAAALALLAAILLLLVVPDPPESA---------RAKNEEASSKSVLKLLKRVLKNPGLWLLLLA 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 270 S--TNVTYYMLLTYMPSYLSHNLHYSEDHGVLIIIAIMVGMLFVQPVIGMLSDRFGRRPFILVGSVALFTLSIPAFIMIN 347
Cdd:cd06174 212 IflVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAP 291
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 348 SNVIGLIFAGLLLLAVVLncFIGVMASSLPAMFPTHIRFSALASAFNISVLIAGLTPTLAAWLVETTQNLMMPAYYLMVI 427
Cdd:cd06174 292 SLLLLLLLLLLLGFGLGG--LLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVL 369
|
....*.
gi 505181589 428 AVIGLI 433
Cdd:cd06174 370 LLLAAI 375
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
64-433 |
5.01e-16 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 79.54 E-value: 5.01e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 64 QMIAALGTFSVPFLIrplGGLFFGMLGDKYGRQKILAITIVIMSISTFCIGLIPSYATigiwapilLLLCKMAQGFSVGG 143
Cdd:cd17319 39 QYGLIASAFFLGYAL---FQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTS--------LYVLRFLLGVAEAG 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 144 EYTGASIFVAEYSPDRKRGFMGSWLDFGSIAGFVMGAGVVVLISsvvgeenfLDWGWRIPFFLalpLGIIGLYLRHALee 223
Cdd:cd17319 108 FFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLL--------LLFGWRWAFII---EGLLGLLLAVLW-- 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 224 tpafqqhvdtleqgdreglqegpkvsfkeiatkhWRSLLTCIGLVIS---TNVTYYMLLTYMPSYLSHNLHYSEDHGVLI 300
Cdd:cd17319 175 ----------------------------------WFYLRQVWGLALGyfgINYALYGLLTWLPTYLKQARGFSLKQVGLL 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 301 IIAIMVGMLFVQPVIGMLSDRF--GRRPFILVGSVALFTLSIPAFIMINSNVIGLIFAGLLllavvlNCFIGVMASSLPA 378
Cdd:cd17319 221 AAIPFLAGAIGMILGGRLSDRLlrGARRLVIIIGLLLAAVGLLLAYLTTSPVVAVILLSLA------GFGIGAASPVFWS 294
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 505181589 379 MFPTHIRFSALASAFNI----SVLIAGLTPTLAAWLVETTQNLMMPAYYLMVIAVIGLI 433
Cdd:cd17319 295 LPADLLPGEAAATAGGLinsgGNLGGFVAPLLIGYLVDATGSYTAAFLFLAAVALLAAL 353
|
|
| MFS_PhT |
cd17364 |
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This ... |
39-218 |
1.16e-14 |
|
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of predominantly fungal and plant high-affinity inorganic phosphate transporters (PhT or PiPT), which are involved in the uptake, translocation, and internal transport of inorganic phosphate. They also function in sensing external phosphate levels as transceptors. Phosphate is crucial for structural and metabolic needs, including nucleotide and lipid synthesis, signalling and chemical energy storage. The Pht subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340922 [Multi-domain] Cd Length: 389 Bit Score: 75.39 E-value: 1.16e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 39 FDFGVYGFVAYALGKVFF--PDADPS-----VQMIAALGTFsvpflirpLGGLFFGMLGDKYGRQKILAITIVIMSISTF 111
Cdd:cd17364 13 YDLFSISLVTKILGRLYYggKGSLPSgvsglVNAAALVGTI--------IGQLFFGFLGDRFGRKRVYGVELIIMIIGTI 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 112 CIGLIPSYATIGIWApiLLLLCKMAQGFSVGGEYTGASIFVAEYSPDRKRGFM----GSWLDFGSIAGfvmgaGVVVLIS 187
Cdd:cd17364 85 LSALSPGSTPLGVMG--WLIFFRFLLGIGIGGDYPLSATIMSEYANKKRRGALiaavFAMQGFGILAG-----AIVTLIL 157
|
170 180 190
....*....|....*....|....*....|....*...
gi 505181589 188 SVVGEENF-------LDWGWRIPFFLALPLGIIGLYLR 218
Cdd:cd17364 158 SAIFEHPLpagtyhhADLVWRIVLGLGAIPALSVLYFR 195
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
72-438 |
1.81e-14 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 74.91 E-value: 1.81e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 72 FSVPFLIRPLGGLFFGMLGDKYGRQKILAITIVIMSISTFCIGLIPSYAtigiwapiLLLLCKMAQGFSVGGEYTGASIF 151
Cdd:COG2807 59 TTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVA--------LLLAGTALIGAGIAVGNVLLPGL 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 152 VAEYSPDRkRGFMGSWLDFGSIAGFVMGAGVVVLISSVvgeenfldWGWRIPF-FLALPLGIIGLYLRHALEETPAFQQH 230
Cdd:COG2807 131 IKRWFPDR-VGLMTGLYTAAMGLGAALAAGLTVPLAAA--------LGWRGALaVWALLALLALLLWLPLLRRRPAAAAA 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 231 vdtleqgdreglqEGPKVSFKEIatkhWRS----LLTCIGLVIStnVTYYMLLTYMPSYLsHNLHYSEDHGVLIIIAIMV 306
Cdd:COG2807 202 -------------APAAASLRSL----WRSplawLLTLFFGLQS--LLYYAVVAWLPPIL-RDAGLSAATAGLLLSLFQL 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 307 GMLFVQPVIGMLSDRFGRRPFILVGSVALFTLSIpafiminsnvIGLIFAGLLLLAVVLnCFIGVMASSLPAMFPTHI-- 384
Cdd:COG2807 262 AGIPGSLLVPLLADRLGDRRPLLLLLGLLGLAGL----------LGLLLAPGSLPWLWA-VLLGLGQGGLFPLALTLIgl 330
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 505181589 385 -----RFSALASAFNISV--LIAGLTPTLAAWLVETTQNLMMPAYYLMVIAVIGLITGLSM 438
Cdd:COG2807 331 rartpAEAAALSGMAQSVgyLLAALGPLLVGALHDATGSWTAALLLLAALAVLMLVAGLLA 391
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
81-436 |
2.67e-14 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 74.53 E-value: 2.67e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 81 LGGLFFGMLGDKYGRQKILAITIVIMSISTFCIGLIPSYATIGIWAPILlllckmaqGFSVGGEYTGASIFVAEYSPDRK 160
Cdd:cd17359 51 IGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFTIFIIARIIG--------GLAVGGASALVPMYIAEVAPAEI 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 161 RGFMGSWLDFGSIAGFVMGAGVVVLISSVVGEENFLDWGWRIPFFLALPLGIIGLYLRHALEETPAFqqhvdtleqgdre 240
Cdd:cd17359 123 RGRLVSLNQLMIVFGQLLAYIVNYLIANAGGADWLGAEGWRWMLGLEAIPAILFLLGMLFIPESPRW------------- 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 241 glqegpkvsfkeIATKHWRSLLTCIGL-----VISTNVTYYmlltYMPSYLShNLHYSEDHGVLIIIAIMVgMLFVQPVI 315
Cdd:cd17359 190 ------------LVSKGKPILIIGIGLaifqqFVGINVIFY----YGPEIFQ-NAGFSENAALLQTIGIGV-VNVIFTII 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 316 GM-LSDRFGRRPFILVGS----VALFTLSIPAFIMINSNVIGLIfaglllLAVVLNCFIGVMASS--------LPAMFPT 382
Cdd:cd17359 252 AIlLVDKVGRKPLLLIGSigmaISLLLIGTAFYFAPGSQASGIV------ALVLILLFVAFFAMSwgpvtwvlLSEIFPN 325
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 505181589 383 HIRFSALAsafnisvlIAGLTPTLAAWLVETTQNLMM----PAYYLMVIAVIGLITGL 436
Cdd:cd17359 326 RIRGLAMG--------IAVFFLWIANFLVSLTFPILLaafgLAFTFLIFAVICVLAFL 375
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
77-436 |
8.79e-14 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 73.40 E-value: 8.79e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 77 LIRPLGGLFFGMLGDKYGRQK-ILAITIVIMSISTFCIGLIPSYATIG--IWAPILLLLCKMAqgfsvggeYTGASI--- 150
Cdd:COG2211 61 ITDPLIGALSDRTRTRWGRRRpWILIGAIPLALSFVLLFTAPDLSPTGklIYALVTYLLLGLA--------YTLVNIpys 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 151 -FVAEYSPDRK-RGFMGSWLDFGSIAGFVMGAGVVVLISSVVGEENFldWGWRIPFFLALPLGIIGLYL-RHALEETPAf 227
Cdd:COG2211 133 aLGAELTPDYEeRTRLSSWRFAFAGLGGLLASVLPPPLVAAFGGDAA--LGYRLTALIFAVLGLLAFLLtFFGTKERPV- 209
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 228 qqhvdtleqgdreglQEGPKVSFKEI--ATKHWRSLLTCIGLVISTNVTYYMLLTYMPSYLSHNLHYSEDHGVLIIIAIM 305
Cdd:COG2211 210 ---------------PEEEKVSLKESlkALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYF 274
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 306 VGMLFVQPVIGMLSDRFGRRPFILVGSVALFTLSIPAFIMINSNVIGLIFaglllLAVVLNCFIGVMASSLPAMFP---- 381
Cdd:COG2211 275 LAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPGNLWLLLV-----LAALAGIGLGAILVLPWAMLAdvvd 349
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 505181589 382 -----THIRFSALASAFN--ISVLIAGLTPTLAAWLVE----------TTQNLMMPAYYLMVIAVIGLITGL 436
Cdd:COG2211 350 ydewkTGRRREGLYFGIFtfAIKLGQALAGALAGLLLAlfgyvagaaqSPSALTGIRLLFFLLPAVLLLLAA 421
|
|
| SP |
TIGR00879 |
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of ... |
30-447 |
1.12e-13 |
|
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of the major facilitator superfamily (pfam00083) [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273317 [Multi-domain] Cd Length: 481 Bit Score: 73.14 E-value: 1.12e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 30 ASLGNAMEWFDFGVY-GFVAYALGKVFFPDADPSVQMIAALGTFSVPFLIRPL-GGLFFGMLGDKYGRQKILAItIVIMS 107
Cdd:TIGR00879 33 AAIGGLMFGYDTGVIgGALALPAFEFKFTSANSDSYSSSLWGLVVSIFLVGGFiGALFAGWLSDRFGRKKSLLI-IALLF 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 108 ISTFCIGLIPSYATIGIWAPILLLLCkmaqGFSVGGEYTGASIFVAEYSPDRKRGFMGS----WLDFGSIAGFVMGAGVV 183
Cdd:TIGR00879 112 VIGAILMGLAAFALSVEMLIVGRVLL----GIGVGIASALVPMYLSEIAPKALRGALTSlyqlAITFGILVAYGFGSGKV 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 184 VLISSVvgeenfldwGWRIPFFLALPLGIIGLYLRHALEETPAFQQHVDTLEQG-------------DREGLQEGPKVSF 250
Cdd:TIGR00879 188 SLNNTL---------GWRIPLGLQLIPAGLLFLGLFFLPESPRWLVGKGRVEEArkslarlrgtsgeDKELLDELELIDI 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 251 KEIATKH-----WRSLLTC-----------IGLVISTNVTYYMLLTYMPSYLSHNLHYSEDHGVLIIIAIM-VGMLFVQP 313
Cdd:TIGR00879 259 KRSIEKRsvqpsWGSLFSStrrirrrlflgVVLQWFQQFTGINAIMYYSPTIFENAGVSTDHAFLVSIIVGaVNFAFTFV 338
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 314 VIgMLSDRFGRRPFILVG----SVALFTLSIPAFIMINSNVIGLIFAGLLLLAVVLNCF---IGVMASSLPA-MFPTHIR 385
Cdd:TIGR00879 339 AI-FLVDRFGRRPLLLIGaagmAICLFVLGILGASFVTGSSKSSGNVAIVFILLFIAFFamgWGPVPWVIVSeIFPLSLR 417
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 386 FSALASAFN----ISVLIAGLTPTLaawlvettQNLMMPAYYLMVIAVIGLITGLSMK----ETANRPLK 447
Cdd:TIGR00879 418 PKGISIAVAanwlANFIVGFLFPTM--------LESIGVGGVFIFFGGLNVLGLIFVYfflpETKGRTLE 479
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
84-335 |
1.34e-13 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 72.21 E-value: 1.34e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 84 LFFGMLGDKYGRQKILAITIVIMSISTFCIGLIPSyatigiwaPILLLLCKMAQGFSVGGEYTGASIFVAEYSPDRKRGF 163
Cdd:cd17321 49 LLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPS--------LAFLIAARALQGIGAAAIMPASLALIAATFPGERRGR 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 164 MGSWLDFGSIAGFVMGAgvvvLISSVVGEenflDWGWRIPFFLALPLGIIGLYLrhaleeTPAFqqhvdtleqgdreglq 243
Cdd:cd17321 121 ALGLWGAVVGIGAALGP----LLGGLLLE----LFGWRWIFLINVPIGLVALLL------ARTF---------------- 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 244 egpkvsfkeiatkhwrsLLTCIGLVIsTNVTYYMLLTYMPSYLSHNLHYSEDHGVLIIIAIMVGMLFVQPVIGMLSDRFG 323
Cdd:cd17321 171 -----------------SGAVLAAFL-LGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFG 232
|
250
....*....|..
gi 505181589 324 RRPFILVGSVAL 335
Cdd:cd17321 233 PRLVLVAGLLLT 244
|
|
| 2A0109 |
TIGR00887 |
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the ... |
25-245 |
2.53e-13 |
|
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the major facilitator superfamily (pfam00083). [Transport and binding proteins, Anions]
Pssm-ID: 129965 [Multi-domain] Cd Length: 502 Bit Score: 72.07 E-value: 2.53e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 25 KAITAASLGNAMEWFDFGVYGFVAYALGKVFF-------PDADPSVQMIAALGTfsvpflirPLGGLFFGMLGDKYGRQK 97
Cdd:TIGR00887 16 RAIVIAGVGFFTDSYDLFCISLVTKMLGYVYYhgkgplpSSVSAAVNGSASIGT--------LAGQLFFGWLADKLGRKR 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 98 ILAITIVIMSISTFCIGLIPSYATIGIWApiLLLLCKMAQGFSVGGEYTGASIFVAEYSPDRKRG-FMGSWLDFgsiAGF 176
Cdd:TIGR00887 88 VYGMELIIMIIATVASGLSPGSSPKSVMA--TLCFWRFWLGVGIGGDYPLSAIITSEFATKKWRGaMMAAVFAM---QGF 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 177 -VMGAGVVVLISSVVGEENF----------------LDWGWRIPFFLALPLGIIGLYLRHALEETPAFQQHV-DTLEQG- 237
Cdd:TIGR00887 163 gILAGAIVALIVLAGFKHSLeaaadeasctgscvpaVDYMWRILIGFGAVPALLALYFRLTIPETPRYTADVaKDVEQAa 242
|
....*....
gi 505181589 238 -DREGLQEG 245
Cdd:TIGR00887 243 sDMSAVLQV 251
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
85-430 |
3.16e-13 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 71.05 E-value: 3.16e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 85 FFGMLGDKYGRQKILAITIVIMSISTFCIGLIPSYAtigiwapiLLLLCKMAQGFSVGGEYTGASIFVAEYSPDRKRGFM 164
Cdd:cd17478 50 LFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYW--------LLLLLVALAGIGSAAFHPEGARLASQAAGGRRGLAM 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 165 GSWLDFGSIaGFVMGAGVVVLIssvvgeenFLDWGWRIPFFLALPLGIIGLYLRHALEETPAfqqhvdtleqgdREGLQE 244
Cdd:cd17478 122 SIFSVGGNL-GFALGPLIAAAL--------VALFGGLGLLILLIIPGLAVALLLLRLRPLKK------------PEAKKA 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 245 GPKVSFKEIATKHWRSLLTCIGLVISTNVTYYMLLTYMPSYLSHNLhYSEDHGVLIIIAIMVGMLFVQPVIGMLSDRFGR 324
Cdd:cd17478 181 AAKSSARSTLKGVWRALLLLLIIVFLRSWVLSSLTTFLPFYLVQRG-YSLVFAGLLLSLFLFAGAIGTLIGGPLSDRFGR 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 325 RPFILVGsvalFTLSIPAFI-MINSNVIGLIFAGLlllavvlnCFIGVMASSLPAM-------FPTHIrfsALASA--FN 394
Cdd:cd17478 260 RRVIIAS----LLLAAPFLLlFLLTPGIWSYILLV--------LAGFLLFASFPVTvvlaqelLPGNV---GLASGlmMG 324
|
330 340 350
....*....|....*....|....*....|....*...
gi 505181589 395 ISVLIAGLTPTLAAWLVETT--QNLMMPAYYLMVIAVI 430
Cdd:cd17478 325 LSFGLGGIGAPVLGALADAFglESVLLILALLPLLGAL 362
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
50-355 |
7.24e-13 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 69.91 E-value: 7.24e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 50 ALGKVFFPDADPSVQMIaalgtFSVPFLIRPLGGLFFGMLGDKYGRQKILAITIVIMSISTFCIGLIPSYatigiwapIL 129
Cdd:cd17473 24 AIAQHFVPNSELLVPLL-----LTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSL--------YA 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 130 LLLCKMAQGFSVGGEYTGASIFVAEYSPDRKRGFMgswldFGSIAGFV-MGAGVVVLISSVVGEenfldWGWRIPFFL-A 207
Cdd:cd17473 91 LLASRALLGIGVAGIMTLATALIGDYFEGEERAKM-----LGLQSAAMsLGGVVFLLLGGALAE-----IGWRAPFLVyL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 208 LPLGIIGLYLRhALEETPAFQQHVDtleqgdreglqegpKVSFKEIATKHWRSLLTCIGLVISTNVTYYMLLTYMPSYLS 287
Cdd:cd17473 161 LALPVLILVLL-FLPEPARKSKSAA--------------SPGAATAAALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQ 225
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 505181589 288 HNLHYSEdhgVLIIIAIMVGMLFVqPVIGMLSDRFGRR---PFILVGSVALFTLSIpAFIMINSNVIGLIF 355
Cdd:cd17473 226 ERGGGSA---ALIGLALAIASLAG-AIGALLFGRLKRRlgkRRLLAIGFALMALGF-LLLALASGLWVVLL 291
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
62-434 |
5.54e-12 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 67.23 E-value: 5.54e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 62 SVQMIAALgtfsvpfLIRPLGGLffgmLGDKYGRQKILAITIVIMSISTFCIGLIPSyatigiwaPILLLLCKMAQGFSV 141
Cdd:cd17489 38 GLFTLAAL-------LARPFAGR----LLDRFGRKRLLLIGLLIFALATLLYLLATS--------VALLLVLRLIHGIGW 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 142 GGEYTGASIFVAEYSPDRKRGFMGSWLDFGSIAGFVMGAGVVVLISSVvgeenfldWGWRIPFFLALPLGIIGLYLrhal 221
Cdd:cd17489 99 GAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQH--------LGFAVLFIVAAVLALLALLL---- 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 222 eetpAFQQHVDTLEQGDREGLQEGPKVSFKEIatkhwRSLLTCIGLVISTnVTYYMLLTYMPSYLSHNLHyseDHGVLII 301
Cdd:cd17489 167 ----VFLVKDPPPVAAEEAEAGTRAFRRLVEK-----KVLPPALILFLAS-IAYGAISTFLPLYAAERGI---SNAGLFF 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 302 IAIMVGMLFVQPVIGMLSDRFGRR----PFILVGSVALFTLSI---PAFIMINSNVIGLIFAGLLLLavvlncfIGVMAS 374
Cdd:cd17489 234 TVYAIALLLSRPFSGKLSDRKGPKtviiPGLLLLALGLLLLSFagsPWMLLLAAVLYGLGFGLLFPA-------LQALAV 306
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 505181589 375 SLPamfPTHIRFSALaSAFNISVLIA-GLTPTLAAWLVETTQNLMMPAYYLMVIAVIGLIT 434
Cdd:cd17489 307 DLV---PPHRRGAAN-GTFFIFFDLGiGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVLY 363
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
84-436 |
9.76e-12 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 66.44 E-value: 9.76e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 84 LFFGMLGDKYGRQKILAITIVIMSISTFCIGLIPSYATigiwapilLLLCKMAQGFSVGGEYTGASIFVAEYSPDRKRGF 163
Cdd:cd17474 52 PVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFAL--------LLAGRALQGIGAAGLGPLALTLIGDLFEGGERAK 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 164 -MGswldfgsIAGFVMGAGVVV--LISSVVGeenflDWGWRIPFFL-ALPLGIIGLYLRHALEETPAFQQHVDTLEQGDr 239
Cdd:cd17474 124 aMG-------LYEAALGLGIAVgpLLGGLLA-----AISWRYPFFLlAALIPVAFLAILFLLPEPKEKAKSSSATKLRD- 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 240 eglqegpkvsfkEIATKHWRSLLTCIGLVISTNVTYYMLLTYMPSYLSHNLHYSEDHGVLIIIAIMVGMLFVQPVIGMLS 319
Cdd:cd17474 191 ------------LKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLL 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 320 DRFGRRPFILVGSVALFTLSIPAFIMINSNVIGLIFAGLLLLavvlncFIGVMASSLPAM----FPTHIRfsALASAFNI 395
Cdd:cd17474 259 KKRFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGL------GLGLNLPLLTTLvtelAPEEER--GTASSLYN 330
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 505181589 396 SVLIAGLT--PTLAAWLVEttqNLMMPAYYLmVIAVIGLITGL 436
Cdd:cd17474 331 FVRFLGQAvgPLLFGLLLE---IFGLSAPFL-VGAAIALAAAV 369
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
63-355 |
1.63e-11 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 66.03 E-value: 1.63e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 63 VQMIAALGTFsvpflirpLGGLFFGMLGDKYGRQKILAITIVIMSISTFCIGLIPSYatigiwapILLLLCKMAQGFSVG 142
Cdd:COG0738 48 LLFAFFLGYL--------LASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSY--------PLLLLALFLLGLGLG 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 143 GEYTGASIFVAEYSPDRKRGFMgSWLD-FGSIAGFVMGAGVVVLISSvvgeenFLDWGWRIPFFL--ALPLGIIGLYLRH 219
Cdd:COG0738 112 LLDVAANPYVAALGPETAASRL-NLLHaFFSLGALLGPLLGGLLILL------GLSLSWHLPYLIlaVLLLLLALLFLRS 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 220 ALEETPAfqqhvdtleqgdREGLQEGPKVSFKEIAtKHWRSLLTCIGLVISTnVTYYMLLTYMPSYLSHNLHYSEDHGVL 299
Cdd:COG0738 185 KLPEIEE------------EEEEAAGSAASLKSLL-KNPRLLLGGLAIFLYV-GAEGAIGDWLPLYLKDVLGLSEATAAL 250
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 505181589 300 IIIAIMVGMLFVQPVIGMLSDRFGRRPFILVGSVALFTLSIpAFIMINSNVIGLIF 355
Cdd:COG0738 251 GLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLL-LALLAPGPWLALIG 305
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
34-438 |
1.91e-11 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 65.30 E-value: 1.91e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 34 NAMEWFDFGVYGFVAYALGKvffpDADPSVQMIAALGTFSVPFLIrpLGGLFFGMLGDKYGRQKILAITIVIMSISTFCI 113
Cdd:cd17365 8 IVLDGFDLAVMGFVAPALAQ----DWGLSPAQLGPVGSAALFGMA--IGALLAGPLADRFGRKRVLLVSVALFGLFTLLT 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 114 GLIPSYATIGIWApillLLCkmaqGFSVGGEYTGASIFVAEYSPDRKRGFMGSWLdfgsIAGFVMGAGVVVLISSVVGEE 193
Cdd:cd17365 82 AFAQSVLQLALLR----FLT----GLGLGAAMPNAITLVSEYAPARRRSLAVTLM----FCGYPLGAALGGFLAAALIPA 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 194 nfldWGWRIPFFL-ALPLGIIGLYLRHALeetpafqqhvdtleqgdreglqegpkvsfkeiatkhWRSLLTCIGLVIstn 272
Cdd:cd17365 150 ----FGWRSVFLLgGVPPLILLPLLRGTL------------------------------------LLWVTFFMGLLL--- 186
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 273 vtYYMLLTYMPSYLSHNlHYSEDHGVLIIIAIMVGMLFVQPVIGMLSDRFGRRpFILVGSVALFTLSIPAFIMINSNVIG 352
Cdd:cd17365 187 --VYLLNSWLPKLMVEA-GYSLSQALTITLLLNIGGVIGSLLLGWLADRFGPK-RVLALFFALGAVSLALLGVSPASLVL 262
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 353 LIFAGLLLLAVVLNCFIGVMASSlPAMFPTHIRFSALASAFNISVLIAGLTPTLAAWLVettQNLMMPAYYLMVIAVIGL 432
Cdd:cd17365 263 LYVLVFLAGACVNGAQVGLYALA-ARFYPTEVRATGVGWALGVGRLGAILGPLLGGLLL---AAGLGPESVFLALAIPAA 338
|
....*.
gi 505181589 433 ITGLSM 438
Cdd:cd17365 339 LGALAV 344
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
81-446 |
5.00e-10 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 61.57 E-value: 5.00e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 81 LGGLFFGMLGDKYGRQKILAITIVIMSISTFCIGLIPSYatigIWAPILLLLckmaQGFSVGGEYTGASIFVAEYSPDRK 160
Cdd:TIGR00898 142 LGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNY----TVFLVFRLL----VGMGIGGIWVQAVVLNTEFLPKKQ 213
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 161 RGFMGSWLDFGSIAGFVMGAGVVVLISsvvgeenflDWGWrIPFFLALPLGIIGLY------------LRHALEETPAFQ 228
Cdd:TIGR00898 214 RAIVGTLIQVFFSLGLVLLPLVAYFIP---------DWRW-LQLAVSLPTFLFFLLswfvpesprwliSQGRIEEALKIL 283
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 229 QHV----------DTLEQGDREGLQEGPKV-SFKEIATKHW--RSLLTCIGLVISTNVTYYMLLTYMPsylshNLHYSed 295
Cdd:TIGR00898 284 QRIakingkklpaEVLSLSLEKDLSSSKKQySFLDLFRTPNlrKTTLCLMMLWFTTAFSYYGLVLDLG-----NLGGN-- 356
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 296 hgVLIIIAIMVGMLFVQPVIGMLS-DRFGRRP-----FILVGSVALFTLSIPAfiMINSNVIGLIFAGLLLLAVVLNCfI 369
Cdd:TIGR00898 357 --IYLDLFISGLVELPAKLITLLLiDRLGRRYtmaasLLLAGVALLLLLFVPV--DLYFLRTALAVLGKFGITSAFQM-V 431
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 505181589 370 GVMASSLpamFPTHIRFSALASAFNISVLIAGLTPtLAAWLVETtqNLMMPAYYLMVIAVIGLITGLSMKETANRPL 446
Cdd:TIGR00898 432 YLYTAEL---YPTVVRNLGVGVCSTMARVGSIISP-FLVYLGEK--WLFLPLVLFGGLALLAGILTLFLPETKGVPL 502
|
|
| MFS_GLUT10_12_Class3_like |
cd17362 |
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ... |
81-340 |
7.80e-10 |
|
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340920 [Multi-domain] Cd Length: 389 Bit Score: 60.83 E-value: 7.80e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 81 LGGLFFGMLGDKYGRQKILAITIVIMSISTFCIGLIPSYAtigiwapiLLLLCKMAQGFSVGGEYTGASIFVAEYSPDRK 160
Cdd:cd17362 54 LGSLVAGALIDRLGRRKELILAALLYLVGSLVTGLAPSYP--------VLLVGRLIYGVGIGLAMHAAPVYIAETSPSHI 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 161 RGFMGSWLDFGSIAGFVMGAGVVVLISSVVgeenfldWGWRIPFFLALPLGII---GLYLrhaLEETPAFQQhvdtleqg 237
Cdd:cd17362 126 RGLLVSLKELFIVLGILLGYVSGYAFADVV-------GGWRYMYGLAAPPALLlgiGMWF---LPPSPRWQG-------- 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 238 dreglqegpkvsfkeiatKHWRSLLTCIGLVISTNVT-YYMLLTYMPSYLSHNLHYSEDHGVLIIIAIMVGMLFVQPVIG 316
Cdd:cd17362 188 ------------------NYRKPLIIGLGLVLFQQITgQPSVLYYAATIFKSAGFSAASDATLVSVGLGVFKLLMTIVAV 249
|
250 260
....*....|....*....|....*...
gi 505181589 317 MLSDRFGRRPFILVGS----VALFTLSI 340
Cdd:cd17362 250 LLVDKLGRRPLLLGGVsgmvVSLFLLAA 277
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
81-355 |
8.87e-10 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 60.26 E-value: 8.87e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 81 LGGLFFGMLGDKYGRQKILAITIVIMSISTFCIGLIPSyatigiwaPILLLLCKMAQGFSVGGEYTGASIFVAEYSPDRK 160
Cdd:cd17477 46 LGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDS--------PWVWFLLRFVMGIGLAGLFVVSESWLNALATNEN 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 161 RGFMGSWLDFGSIAGFVMGAGVVvlisSVVGEENFLdwgwriPF-----FLALPLGIIGLYLRHALEETPAfqqhvdtle 235
Cdd:cd17477 118 RGRVLGLYSTVLGLGFALGPLLL----ALVGTAGAL------PFliaavLLLLALVPLLLTRRAAPEIEEA--------- 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 236 qgdreglqegPKVSFKEIATKHWRSLLTCI--GLVISTnvtyymLLTYMPSYLSHnLHYSEDHGVLIIIAIMVGMLFVQP 313
Cdd:cd17477 179 ----------ESISLRRLLRIAPLALLGAFvaGFLEGA------FYSLLPLYGLR-LGLSVAQAALLLAAFVLGGLLLQW 241
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 505181589 314 VIGMLSDRFGRRPFILVGSVALFTLSIPAFIMINSNVIGLIF 355
Cdd:cd17477 242 PLGWLADRFDRRRVLLGCALLGALAALLLPLVPGLPLALLVL 283
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
87-355 |
5.08e-09 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 57.97 E-value: 5.08e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 87 GMLGDKYGRQKILAITIVIMSISTFCIGLIPSYATigiwapilLLLCKMAQGFSVGGEYTGASIFVAEYSPDRKRGFMGS 166
Cdd:cd17503 52 GWLADRFGTRRLFLTALALFTLGSLLCGLAPNLAS--------LIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMG 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 167 WLDFGSIAGFVMG---AGVVVlissvvgeENFldwGWRIPFFLALPLGIIGLYLrhaleetpafqqhvdtleqgdreglq 243
Cdd:cd17503 124 LVGLVILLAPAIGptlGGWLT--------DNL---SWRWIFYINLPIGILALLL-------------------------- 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 244 eGPKVSFKEIATKHWRSLLTCIGLVistNVTYYMLLTYMPSYLSHNLHYSEDHGVLIIIAIMVGMLFVQPVIGMLSDRFG 323
Cdd:cd17503 167 -APLLDLRLFKDRNFTLGLLLSFLL---GLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFG 242
|
250 260 270
....*....|....*....|....*....|...
gi 505181589 324 RRPFILVGSVAL-FTLSIPAFIMINSNVIGLIF 355
Cdd:cd17503 243 PRLLLLAGLLLLaLGTLLLAFLTPDTSLWLIIL 275
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
82-334 |
5.33e-09 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 58.05 E-value: 5.33e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 82 GGLFFGMLGDKYGRQKILaitivIMSISTFciGLIpSYATIGIWAPILLLLCKMAQGFSVGGEYTGASIFVAEYSPDRKR 161
Cdd:PRK11551 66 GALLGGRLADRIGRKRIL-----IVSVALF--GLF-SLATAQAWDFPSLLVARLLTGVGLGGALPNLIALTSEAVGPRLR 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 162 GFMGSwldfgsiagfVMGAGVVV--LISSVVGEENFLDWGWRIPFFL--ALPLGIIGLYLRHaLEETPAFQQhvdtleqg 237
Cdd:PRK11551 138 GTAVS----------LMYCGVPFggALASVIGVLAAGDAAWRHIFYVggVGPLLLVPLLMRW-LPESRAFAQ-------- 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 238 drEGLQEGPKVSFKEIATKHWRSLLTcIGLVIS---TNVTYYMLLTYMPSYLSHNlHYSEDHGVLIIIAIMVGMLFVQPV 314
Cdd:PRK11551 199 --AAGAGKQRAPVLRALFGEGRATAT-LLLWISyffTLIVLYFLLNWLPSLLVGQ-GLSRSQAGLVQIAFNIGGALGSLL 274
|
250 260
....*....|....*....|...
gi 505181589 315 IGMLSDRFGRRP---FILVGSVA 334
Cdd:PRK11551 275 IGALMDRLRPRRvvlLIYAGILA 297
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
81-340 |
5.42e-09 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 58.02 E-value: 5.42e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 81 LGGLFFGMLGDKYGRQKILAITIVIMSISTFCIGLIPSY-ATIGIWApILLLLCKMAQGFSVGGEYtgasIFVAEYSPDR 159
Cdd:cd17345 53 LSKFVMGNLSDRSNPKRFLAIGLILSAIINILIGFVPSAtSSVGLMF-ILLFLNGWFQGMGWPPSG----RTMVHWFSKK 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 160 KRGFmgsWLDFGSIAGFVMGAGVVVLIssVVGEENFLDWGWR----IPFFLALPLGIIGLYLRHALEET----PAFQQHV 231
Cdd:cd17345 128 ERGT---WTSIWNISHNVGGGLVGPLA--GLGLAIFGDGWWRgafiFPAIIAIIVAVIVLFLGKDTPESeglpPIEEYKG 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 232 DTLEQGDREGlqEGPKVSFKEIATKH-------WrslltcigLVISTNVTYYML----LTYMPSYLSHNLHYSEDHGVLI 300
Cdd:cd17345 203 DYPEEADGEE--EEQELSAWEIFVKYvlknkllW--------YIAIANVFVYLVrygiLDWAPTYLSEVKGFSKAQAMWA 272
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 505181589 301 I----IAIMVGMLfvqpVIGMLSDRF--GRRPFILVGSVALFTLSI 340
Cdd:cd17345 273 FslfeWAAIPGTL----LAGWLSDKLfkGRRAPTGIIFMILVIVAL 314
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
81-354 |
7.98e-09 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 57.20 E-value: 7.98e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 81 LGGLFFGMLGDKYGRQKILAITIVIMSISTFCIGLIPSYATigiwapilLLLCKMAQGFSVGGEYTGASIFVAEYSPDRK 160
Cdd:cd17315 49 IGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWV--------LIVGRFLLGLGVGLASVLVPLYISEIAPAKI 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 161 RGFMGS----WLDFGSIAGFVMGAGVVVLISsvvgeenfldWGWRIPFFLALPLGIIGLYLRHALEETPAfqqhvdtleq 236
Cdd:cd17315 121 RGALGTlnqlMITFGILLAYLLGLALSLSPP----------GWWRLMFALAAVPALLQLLLMFFLPESRA---------- 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 237 gdreglqegpkvsfkeiatkhwrsLLTCIGLVIST-----NVTYYmlltYMPSYLShNLHySEDHGVLIIIAIMVGMLFV 311
Cdd:cd17315 181 ------------------------LLVGVGLQLLQqltgiNAVMY----YAPTIFK-SAG-GGTASILASIIVGVVNLLA 230
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 505181589 312 QPVIGMLSDRFGRRPFILVG----SVALFTLSIPAFIMINSNVIGLI 354
Cdd:cd17315 231 TLVAIRLVDKVGRRPLLLIGfagmAASLLLLAIAFLLPALAKAAGWL 277
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
81-436 |
9.05e-09 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 56.82 E-value: 9.05e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 81 LGGLFFGMLGDKYGRQKILAITIVIMSISTFCIGLIPSYAtigiwapiLLLLCKMAQGFSVGGEYTGASIFVAEYSPDRK 160
Cdd:cd17317 40 IGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYE--------LFLVLRFLVGVTSAGIFTVGFVLGMEIVGPKY 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 161 RGFMGSWLDFGSIAGFVMGAGVVVLISsvvgeenflDWGWrIPFFLALPlGIIGLYLrhaleetpafqqhvdtleqgdre 240
Cdd:cd17317 112 RSFVGILFGLFWALGYMLLALLAYLIR---------DWRW-LQLAISLP-GLLFLLL----------------------- 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 241 gLQEGPKVSFkeiatkhwrsLLTCIGLVIStnVTYYMLLTYMPSyLSHNLH----YSedhGVLIIIAIMVGMLFVqpvig 316
Cdd:cd17317 158 -LWWLPRRTI----------IVGLIWFVTS--LVYYGLSLNSSN-LGGNLYlnffLS---GLVEIPAYFLALLLL----- 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 317 mlsDRFGRRPfILVGS---VALFTLSIpAFIMINSNVIGLIFAGLL-LLAVVLNCFIGVMASSLpamFPTHIRFSALASA 392
Cdd:cd17317 216 ---DRLGRRW-TLSGSlllAGLACLVT-ALLPDDENTLALTLALVGkFAISAAFSVIYLYTAEL---YPTVVRNTGVGLC 287
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 505181589 393 FNISVLIAGLTPTLAAWlveTTQNLMMPayyLMVIAVIGLITGL 436
Cdd:cd17317 288 STVARVGAILAPFIVLL---GKIGPLLP---LIIFGVLALLGGL 325
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
258-413 |
2.09e-08 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 56.14 E-value: 2.09e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 258 WRSLLTCIGLVISTNVTYYMLLTYMPsYLSHNLHYSEDHGVLIIIAIMVGMLFVQPVIGMLSDRFGRRPfILVGSVALFT 337
Cdd:COG2814 9 WLALLALALGAFLSGLGIGIVLPALP-LIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRR-VLLLGLLLFA 86
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 505181589 338 LSIPAFIMINSnvIGLIFAGLLLLAVVLNCFIGVMASSLPAMFPTHIR---FSALASAFNISVLIAgltPTLAAWLVET 413
Cdd:COG2814 87 LGSLLCALAPS--LWLLLAARFLQGLGAGALFPAALALIADLVPPERRgraLGLLGAGLGLGPALG---PLLGGLLADL 160
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
83-347 |
2.34e-08 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 56.09 E-value: 2.34e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 83 GLFFGMLGDKYGRQKILAITIVIMSISTFCIGLIPSYAtigiwapiLLLLCKMAQGFSVGGEYTGASIFVAEYSPDRKRG 162
Cdd:cd17328 51 SPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFW--------QLLLFRALVGIGEASYSPIAPTIIADLFPKEKRT 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 163 FMGSWLDF----GSIAGFVMGAgvvvLISSVVGeenfldwGWRIPFFLALPLGII-GLYLRHALEETPafQQHVDtlEQG 237
Cdd:cd17328 123 RALGVFYFaiplGSGLGYVVGG----LVAQATG-------GWRWAFRVTGVLGVLlAILLLLFVREPP--RGAAE--GGV 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 238 DREGLQEGPKVSFKEIAtKHWRSLLTCIGLVISTNVTyYMLLTYMPSYL---SHNLHYSEDHGVLI--IIAIMVGMLFVq 312
Cdd:cd17328 188 MAKSTATSFLADLKALA-KNPSFILSTLGFTAVSFVT-GALAFWAPTFFlraFGVGDLSSADVGLIfgAITCIAGVLGV- 264
|
250 260 270
....*....|....*....|....*....|....*....
gi 505181589 313 pVIG-MLSDRFGRRP---FILVGSVALFTLSIPAFIMIN 347
Cdd:cd17328 265 -LLGgILADRLRRKTpraDPLVCAVGLLAAAPFLFLALV 302
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
72-433 |
3.30e-08 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 55.74 E-value: 3.30e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 72 FSVPFLIRPLGGLFFGMLGDKYGRQKILAITIVIMSISTFCIGLIPSYATigiwapiLLLLCKMAQGFSVGGEYTGASIF 151
Cdd:cd17355 44 FTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQ-------LYLLWGLLGGGGAGTLAAVAFAT 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 152 VAEYSPDRKRGF-MGSWLDFGSIAGFVMGAGVVVLISsvvgeenflDWGWRIPF----FLALPLGIIGLYLRHALEETPA 226
Cdd:cd17355 117 VAAWWFERRRGLaLGILTAGGGLGSLVFLPLGAALIE---------AFGWRTALlvlaLLALLVLVPVLLLLRRRPADLA 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 227 FQQHVDTLEQGDREGLQEgpkvsfkeiATKHWRSLLTCIGLvISTNVTYYMLLTYMPSYLSHnLHYSEDHGVLIIIAIMV 306
Cdd:cd17355 188 LRAYDDASPASPGSTLKE---------ALRSASFWLLALAF-FLCGFAVVGLIVHLVPYLAD-RGISPAAAAVALALIGL 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 307 GMLFVQPVIGMLSDRFGRRPfILVGSVALFTLSIPAFIMINSNVIGLIFAGLlllavvlncFIGVMASS---LPAMFPTH 383
Cdd:cd17355 257 FNIVGRLLSGWLGDRYSPRR-LLAASYALRALGLALLLLLPFPPLALLLFAA---------LFGLGWGAtvpLTAALAAR 326
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 505181589 384 IRFSALASA-----FNISVLIAGLTPTLAAWLVETTQNLMMPAYYLMVIAVIGLI 433
Cdd:cd17355 327 YFGARSYGTlfglvFAPHQLGSALGPWLGGLLYDRTGSYTAAWALAVALGLIAAL 381
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
67-432 |
8.07e-08 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 54.16 E-value: 8.07e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 67 AALGTFSVPFLirpLGGLFFGMLGDKYGRQKILAITIVIMSISTFCIGLIPSYATIGIWAPILLLLCKMAQG-FSVGGEY 145
Cdd:cd06173 38 LVLAAFFLPFL---LFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLALLGSLSLWLLLVLAFLLGIASaFFGPARQ 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 146 TGASIFVAEYSPDRKRGFMGSWLDFGSIAGFVMGAGVVVLISsvvgeenfLDWGWRIPFFLALPLGIIGLYLRHALEETP 225
Cdd:cd06173 115 ALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLG--------PGGAFAINALSFLLSALLLLFIRRPPPAAP 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 226 AfqQHVDTLEQGDREGLQEgpkvsfkeiaTKHWRSLLTCIGLVISTNVTYYMLLTYMPSYLSHNLHYSEDHGVLIIIAIM 305
Cdd:cd06173 187 G--ESSSLLLRDLREGLRY----------LRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFG 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 306 VGMLFVQPVIGMLSDRFGRRPFILVGsVALFTLSIPAFIMINSNVIGLIFAGLLLLAVVlnCFIGVMASSLPAMFPTHIR 385
Cdd:cd06173 255 VGALLGALLLGRLSKRRRRGRLLLIG-ALLLGLALLVLGLSPSLWLLLAALFLLGLAGG--LFNVPLNTLLQLRVPDELR 331
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 505181589 386 ---FSALASAFNISVLIAGLtptLAAWLVETTqnLMMPAYYLMVIAVIGL 432
Cdd:cd06173 332 grvFSVYNALNSGAMPLGAL---LAGLLADAL--GLSAVFLLAGALLLLA 376
|
|
| MFS_GLUT6_8_Class3_like |
cd17358 |
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ... |
73-436 |
1.23e-07 |
|
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340916 [Multi-domain] Cd Length: 436 Bit Score: 53.73 E-value: 1.23e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 73 SVPFLIRPLGGLFFGMLGDKYGRQKILAITIVIMSISTFCIglipsYATIGIWapiLLLLCKMAQGFSVGGEYTGASIFV 152
Cdd:cd17358 48 SLLTLGALIGALLSGKLADRIGRKRTLLISAIPCILGWLLI-----AFAKDVW---MLYLGRFLAGFGGGAASVVVPVYI 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 153 AEYSPDRKRGFMGS----WLDFGSIAGFVMGagvvvlissvvgeeNFLDWGWrIPFFLALPLGI--IGLYLrhaLEETPA 226
Cdd:cd17358 120 AEIAPKNVRGALGSlnqlLVNIGILLGYVLG--------------SFLPWRT-LALIGAIPPVVflILLFF---IPESPR 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 227 F------------------------QQHVDTLEQGDREGLQEGPKVSFKEIATKHW-RSLLTCIGLVI------STNVTY 275
Cdd:cd17358 182 WlakkgreeeaekslqflrgkdadiSKEAAEIQEELAELEKEAKESSFSDLFQRKYlKPLVIGLGLMLfqqlsgINAVIF 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 276 YMlltympSYLSHNLH--YSEDHGVLIIIAIMVGMLFVQPVigmLSDRFGRRPFILVGSV--ALFTLSIPAFIMINSNVI 351
Cdd:cd17358 262 YA------SSIFDEAGsgLDPNTATIIIGVVQVVGTLVATL---LVDRLGRRPLLLVSAIgmGIGLLALGLYFYLQEHGA 332
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 352 GL----IFAGLLLLAVVLNCFIGVMasSLPA-----MFPTHIRFSALAsafnisvlIAGLTPTLAAWLVETTQNLMM--- 419
Cdd:cd17358 333 LLssvsWLPLVGLVIYIISFSIGLG--PLPWvimseIFPAKIKGLAGS--------LVTLVNWLFAFIVTKTFPFLTlaw 402
|
410
....*....|....*...
gi 505181589 420 -PAYYLMVIAVIGLITGL 436
Cdd:cd17358 403 gASGTFWIFAGICGLALV 420
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
71-436 |
1.32e-07 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 53.73 E-value: 1.32e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 71 TFSVPFLIRPLGGLFFGMLGDKYGRQKILAITIVIMSISTFCIGLIPSYATigiwapilLLLCKMAQGFSVGGEYTGASI 150
Cdd:cd17320 39 TLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQ--------LLIARFLQGLGAAAGSVVARA 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 151 FVAEYSPDRKRgfmgswldfGSIAGFVMGA-GVVVLISSVVGEENFLDWGWRIPF-FLALPLGIIGLYLRHALEEtpafq 228
Cdd:cd17320 111 IVRDLYSGAEL---------AKIFSLLMMIlAIAPALAPLLGGLLLLFFGWRAIFvFLALLGLLLLLLVLLFLPE----- 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 229 qhvdTLEQGDREGLQEGPKVSFKEIATKhwRSLLTCIGLVISTNVTYYMLLTYMPSYLSHNLHYSEDHGVLIIIAIMVGM 308
Cdd:cd17320 177 ----TLPEEKRKPLLSSLLRAYKRVLKN--RRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFGLLFALNAIAL 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 309 LFVQPVIGMLSDRFGRRPFILVGSVALFTLSIPAFIMINSNVIGLI-FAGLLLLAVVLNCFIGVMASSLPAMFPTHIRFS 387
Cdd:cd17320 251 ILGSLLNGRLVRRFGPRRLLRLGLLLLLAAALVLLLAALLGGLSLWpLVAPLFLIFFGFGLIFPNATSLALEPFPHVAGT 330
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 505181589 388 ALASAFNISVLIAGLTPTLAAWLVETTQNLMMPAYYLMVIAVIGLITGL 436
Cdd:cd17320 331 ASALLGFLQFLIGALAGALVGLLPNGTALPMGLLILVLGLLALLLLILL 379
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
62-341 |
3.39e-07 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 52.27 E-value: 3.39e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 62 SVQMIAALgTFSVPFLIRPLGGLFFGMLGDKYGRQKILAITIVIMSISTFCIGLIPSyatigIWApilLLLCKMAQGFsV 141
Cdd:cd17391 33 LVELWSGL-AFSSTFLVSAIFSPIWGRLADRYGRKPMLLRASLGMAIVIGLMAFVTN-----VWQ---LLILRLLQGV-F 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 142 GGEYTGASIFVAEYSPDRKRGFMGSWLDFGSIAGFVMGAgvvvLISSVVGEEnfldWGWRIPFFLALPL----GIIGLYL 217
Cdd:cd17391 103 SGYVPNATALIASQTPKEKSGWALGTLSTGVVAGTLIGP----LLGGFLADL----FGIRNVFFITGGLlflaFLLTLFF 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 218 RHAleetpafqqhvdtleqgDREGLQEGPKVSFKEIatkhWRSlLTCIGLVISTNVTYYMLLT-------YMPSYLSHnL 290
Cdd:cd17391 175 VKE-----------------DFKPVEKKKMVSTKEV----WNS-VPNPSLLISLFVTTFIIQLanqsiepILTLYIRQ-L 231
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 505181589 291 HYSEDHGVLI---IIAIM-VGMLFVQPVIGMLSDRFGRRPFILVGSVALFTLSIP 341
Cdd:cd17391 232 MGDASNLAFIsglVFSATgVSSLLSAPRLGKLGDRIGHHRILLGALLASALLYIP 286
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
84-349 |
8.42e-07 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 51.03 E-value: 8.42e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 84 LFFGMLGDKYGRQKILAITIVIMSISTFCIGLIPSYATigiwapilLLLCKMAQGFSVGGEYTGASIFVAEYSPDRKR-- 161
Cdd:cd17502 48 PIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTM--------LIVGRAIQGIGGGGLMSLAFIIIADLVPPRERgk 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 162 --GFMGSWLDFGSIAGFVMGAgvvVLISSvvgeenfldWGWRIPFFLALPLGIIGLYLrhaleetpafqqhvdtleqgdr 239
Cdd:cd17502 120 yqGYIGAVFGIASVAGPLIGG---AFTDH---------LSWRWCFYINLPIGGLALAL---------------------- 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 240 eglqegpkvsfkeiatkhWRSLLTCIGLVISTNVTYYMLLTYMPSYLSHNLHYSEDHGVLIIIAIMVGMLFVQPVIGMLS 319
Cdd:cd17502 166 ------------------LRTILLSSIFGFLFGGALFGLIYYLPLYFQLVLGDSATKSGVRLLPLIIGLVIGSIISGALI 227
|
250 260 270
....*....|....*....|....*....|
gi 505181589 320 DRFGRRPFILVGSVALFTLSIPAFIMINSN 349
Cdd:cd17502 228 SKTGRYKPLIVIGTILMSVGAGLLTTLTLD 257
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
274-456 |
9.06e-07 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 50.88 E-value: 9.06e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 274 TYYMLLTYMPSYLSHNLHYSEDHGVLIIIAIMVGMLFVQPVIGMLSDRFGRRPFILVGsvaLFTLSIPAFIMINSNVIGL 353
Cdd:pfam07690 11 GRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIG---LLLFALGLLLLLFASSLWL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 354 IFAGLLLLAVVLNCFIGVMASSLPAMFPTHIRFSALASAFNISVLIAGLTPTLAAWLVETTQnlmmPAYYLMVIAVIGLI 433
Cdd:pfam07690 88 LLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFG----WRAAFLILAILSLL 163
|
170 180
....*....|....*....|...
gi 505181589 434 TGLSMKETANRPLKGATPAASDI 456
Cdd:pfam07690 164 AAVLLLLPRPPPESKRPKPAEEA 186
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
81-433 |
1.34e-06 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 50.31 E-value: 1.34e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 81 LGGLFFGMLGDKYGRQKILAITIVIMSISTFCIGLIPSYATIGiwaPILLLLckmaqGFSVGGEYTGASIFVAEYSPDRK 160
Cdd:cd17475 46 VSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLL---VLLFLV-----GAGYGSVQPGGGRAIMRWFPPRE 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 161 RGF-MGswldfgsI--AGFVMGAGVVVLISSVVGEENfldwGWRIPFFLALPLGIIGLYLRHALEETPAFQQHVDTLEQG 237
Cdd:cd17475 118 RGLaMG-------IrqTGVPLGGALAAALLPPLALHY----GWRAAFVVAGLVSILAAVLFWLFYREPPAASAATESAST 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 238 DREGLqegpKVSFKEIATkhWRSLLTCIGLVISTnvtyYMLLTYMPSYLSHNLHYSEDHGVLIIIAIMVGMLFVQPVIGM 317
Cdd:cd17475 187 LLRSL----KEVLRNRDV--WLIAIAGALLVAPQ----FALLTFLLLFLHDHLGLSVVAAGALLAVAQLGGALGRIGLGR 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 318 LSDRF--GRRPFILVGSVALFTLSIPAFIMI-NSNVIGLIFAGLLLLAVVLNCFIGVMASSLPAMFPTHIRFSALASAFN 394
Cdd:cd17475 257 VSDRVfgGRRRPVLVITAAIAAAALLVLSLLsPGTPLWLLVLLLILLGLFAIGWNGLYLTLVAESAGPEQAGTALGLANT 336
|
330 340 350
....*....|....*....|....*....|....*....
gi 505181589 395 ISVLIAGLTPTLAAWLVETTQNLMMPAYYLMVIAVIGLI 433
Cdd:cd17475 337 INFIGIAIGPPLFGLLVDATHSYAPAWLALALLLVLAAL 375
|
|
| MFS_SVOP_like |
cd17372 |
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator ... |
73-218 |
3.41e-06 |
|
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator Superfamily; This subfamily is composed of synaptic vesicle 2 (SV2)-related protein (SVOP), SVOP-like protein (SVOPL), and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP and SVOPL share structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. The SVOP-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340930 [Multi-domain] Cd Length: 367 Bit Score: 49.07 E-value: 3.41e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 73 SVPFLIRPLGGLFFGMLGDKYGRQKILAITIVImsisTFCIGLIPSYATIGIWapILLLLCKMaqGFSVGGEYTGASIFv 152
Cdd:cd17372 41 SVVFAGMMIGSYLWGIVSDKYGRRKGLIISALW----TFYAGFLSAFAPNYMW--LIILRCLV--GLGLGGGPQLASWY- 111
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 505181589 153 AEYSPDRKRGFMGSWLDFGSIAGFVMGAGVVVLISSVVGeenfldWGWRIpFFLALPLGIIGLYLR 218
Cdd:cd17372 112 LEFLPAKSRGTWMVLFSVFWTVGTIFEASLAWLVMPRLG------WRWLL-AFSSVPSSLLLVFYR 170
|
|
| MFS_HXT |
cd17356 |
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ... |
81-225 |
4.10e-06 |
|
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340914 [Multi-domain] Cd Length: 403 Bit Score: 49.17 E-value: 4.10e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 81 LGGLFFGMLGDKYGRQKILAITIVImsistFCIGLIPSYATIGIWApiLLLLCKMAQGFSVGGEYTGASIFVAEYSPDRK 160
Cdd:cd17356 60 FGALISSFLSDRIGRKKSIQIGCVI-----YIIGAIIQVAAIGKWY--QLIVGRIIAGLGVGFASVLVPVYQSEVAPKHI 132
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 505181589 161 RGFMGSWLDFGSIAGFVMGAgvvvlissvvgeenFLDWG---------WRIPFFLALPLGIIGLYLRHALEETP 225
Cdd:cd17356 133 RGTLVSLYQLAITIGILVAY--------------CINYGthkldgsaqWRIPLGLQIVWGLLLLIGMFFLPESP 192
|
|
| synapt_SV2 |
TIGR01299 |
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ... |
73-168 |
5.78e-06 |
|
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.
Pssm-ID: 130366 [Multi-domain] Cd Length: 742 Bit Score: 48.82 E-value: 5.78e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 73 SVPFLIRPLGGLFFGMLGDKYGRQKILAITIVIMSISTFCIGLIPSYATigiwapilLLLCKMAQGFSVGGEYTGASIFV 152
Cdd:TIGR01299 209 LIVYLGMMVGAFFWGGLADKLGRKQCLLICLSVNGFFAFFSSFVQGYGF--------FLFCRLLSGFGIGGAIPIVFSYF 280
|
90
....*....|....*.
gi 505181589 153 AEYSPDRKRGFMGSWL 168
Cdd:TIGR01299 281 AEFLAQEKRGEHLSWL 296
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
84-439 |
5.95e-06 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 48.34 E-value: 5.95e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 84 LFFGMLGDKYGRQKILAITIVIMSISTFCIGLIPSYATigiwapilLLLCKMAQGFSvGGEYTGASIFVAEYSPDRKRGF 163
Cdd:cd17504 49 PILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPV--------LIAGRALQGIG-GAVFPLAFALVREEFPPERVPV 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 164 MGSWLDfgsiAGFVMGAGVVVLISSVVGEenflDWGWRIPFFLALPLGIIGLYLrhaleetpafqqhvdtleqgdreglq 243
Cdd:cd17504 120 AQGILS----ATFGIGAGIGLPLGGWIVQ----HLGWRWIFWTAAPVAVLLAAL-------------------------- 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 244 eGPKVSFKEIATKHWrsLLTCIGLVISTNVTY--YMLLTYMpsylshnLHYSEDHGV--------LIIIAIMVGMLFVQP 313
Cdd:cd17504 166 -VPLIDLRLLRRRNV--LLANITALLAGFGMFmvFQLLPQL-------LQLPTPTGFglgiteagLLLLPGALVMLIAGP 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 314 VIGMLSDRFGRRPFILVGSVaLFTLSIPAFIMINSNVIGLIFAGLLLLAVVLNCFIGV---MASSLPAMFP-------TH 383
Cdd:cd17504 236 LAGRLIARVGPRRVLLIGLV-ISAVGLLLLALLHSSLWALVVALLLIGIGLGLAFASLpniVVESVPPDRTgiatgmnTV 314
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 505181589 384 IR--FSALASAFnISVLIAGLTPTLAAWLVETTQNLMMPAYYLMVIAVIGLITGLSMK 439
Cdd:cd17504 315 LRtiGSAIGPAI-AGAILTTYTVSITSGGVPTEGAYVLAFLIGAALALAALLLSLLIP 371
|
|
| 2A0114euk |
TIGR00894 |
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions] |
72-293 |
6.26e-06 |
|
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
Pssm-ID: 129972 [Multi-domain] Cd Length: 465 Bit Score: 48.59 E-value: 6.26e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 72 FSVPFLIRPLGGLFFGMLGDKYGRQKILAITIVIMSISTFcigLIPSYATIGIwapILLLLCKMAQGFSVGGEYTGASIF 151
Cdd:TIGR00894 82 LSSHFYGQIIIQIPVGYLAGKYVFKWSIGIGMFLSSVISI---VIPWAAGGGI---ALVVFCRVIQGLAQGSVSPATHKI 155
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 152 VAEYSPDRKRGFMGSwldfGSIAGFVMGAGVVVLISSVVGEEnflDWGWRIPFFLALPLGIIGLYLRHAL-EETPAFQQH 230
Cdd:TIGR00894 156 IVKWAPPKERSRLLG----MSTSGFQLGTFIFLPISGWLCES---WGGWPMIFYVFGIVGCAWSLLWFVFpADDPSIHPC 228
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 505181589 231 VDTLEQG------DREGLQEGPKVSFKEIATkhWRSLLTCIGLVISTNVTYYMLLTYMPSYLSHNLHYS 293
Cdd:TIGR00894 229 ISKFEKKyinsslQGQKGSTRQSLPIKAIPK--SLPVWAIWFAIFGHFWLYTILPTYLPTFISWVLRVS 295
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
274-348 |
9.21e-06 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 47.97 E-value: 9.21e-06
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 505181589 274 TYYMLLTYMPSYLsHNLHYSEDHGVLIIIAIMVGMLFVQPVIGMLSDRFGRRPFILVGsVALFTLSIPAFIMINS 348
Cdd:cd17489 11 SFYLLLPVLPLYA-HDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIG-LLIFALATLLYLLATS 83
|
|
| MFS_GLUT_Class1_2_like |
cd17357 |
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ... |
81-355 |
1.03e-05 |
|
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340915 [Multi-domain] Cd Length: 447 Bit Score: 48.03 E-value: 1.03e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 81 LGGLFFGMLGDKYGRQKILAITIVIMSISTFCIGLipSYAtigIWAPILLLLCKMAQGFSVGGEYTGASIFVAEYSPDRK 160
Cdd:cd17357 64 IGSFISAFLANRFGRKNGLLISNALLVVSSLLMFL--SKS---AKSPELLIFGRFLVGIACGLSTGFVPMYLQEISPSEL 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 161 RGFMGSWLDFGSIAGFVMGAgvVVLISSVVGEENfldwGWRIPFFLALPLGIIGLYLRHALEETPAF------------- 227
Cdd:cd17357 139 RGALGSLTQIGVTLGILLGQ--VFGLPSVLGTET----LWPYLLFFPGIPALLQLAALPFFPESPKFlliskgdeeeaek 212
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 228 ------------QQHVDTLEQGDREGLQEGpKVSFKEIATKHWRSLLTCIGLVIST-------NVTYYmlltYMPSYLSh 288
Cdd:cd17357 213 slkflrgieddvDQELEEIKKESEQMGDQK-QVSLMQLLRDPSLRLPLLLVLVVSAsqqfsgiNAIFF----YSTFIFE- 286
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 505181589 289 NLHYSEDHGVLIIIAIMVGMLFVQPVIGMLSDRFGRRPFILVG----SVALFTLSIPAFIMINSNVIGLIF 355
Cdd:cd17357 287 NAGFSPQLAEWANLGIGIVNVLSTIVGPFLIEKVGRRPLLLISlsvcAVALLLMSVFLFLSEQNSWMSYGC 357
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
255-463 |
1.17e-05 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 47.57 E-value: 1.17e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 255 TKHWRsLLTCIGLVISTNVTYYMLLTYMPSYLSHNLHYSEDH-GVLIIIAIMVGMLFvQPVIGMLSDRFGRRpfiLVGSV 333
Cdd:COG2223 1 SGRWR-VLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQlGLLFAIPVLVGALL-RIPLGFLVDRFGPR---RVLLI 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 334 ALFTLSIPAFIM-INSNVIGLIFAGLLLLAVVLNCFIGVMAsSLPAMFPTHIRFSAL---ASAFNISVLIAGLtptLAAW 409
Cdd:COG2223 76 GLLLLGIGLLLLaLAVSYWLLLLLGLLLGIGGGGSFAVGIA-LVSKWFPPDRRGLALglaAGGGNLGAAVAAF---LAPL 151
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 505181589 410 LVETTQNLMMPAYYLMVIAVIGLITGLSMKETanrPLKGATPAASDIQEAKEIL 463
Cdd:COG2223 152 LIAAFGWRNAFLILGILLLVVAVLAWLFLRDP---PAGAAAAAKASLRDQLEAL 202
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
271-463 |
1.67e-05 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 47.19 E-value: 1.67e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 271 TNVTYYMLLTYMPSYLSHnLHYSEDHGVLIIIAIMVGMLFVQPVIGMLSDRFGRRPFILVGsvaLFTLSIPAFIMINSNV 350
Cdd:cd17325 8 DMLGYGIIIPILPLYAES-LGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLG---LLLLAVSTLLFAFATS 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 351 IGLIFAGLLLLAVVLNCFIGVMASSLPAMFPTHIR---FSALASAFNISVLIAgltPTLAAWLVETTqNLMMPAYYLMVI 427
Cdd:cd17325 84 YWQLLLARFLQGLASAAVWPAAMALIADIAPPEERgraMGIFSSAIGLGFLIG---PLLGGLLADAL-GYRAPFLVCAAL 159
|
170 180 190
....*....|....*....|....*....|....*..
gi 505181589 428 AVIGLITGLSM-KETANRPLKGATPAASDIQEAKEIL 463
Cdd:cd17325 160 ALLALVLALLLlPEPRPPPNKRAVSAARLRSGLRLLL 196
|
|
| MFS_SLC22A6_OAT1_like |
cd17446 |
Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar ... |
81-206 |
1.71e-05 |
|
Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar transporters of the Major Facilitator Superfamily; This subfamily includes solute carrier family 22 member 6 (SLC22A6, also called organic anion transporter 1 or OAT1 or para-aminohippurate (PAH) transporter), SLC22A8 (or OAT3), and SLC22A20 (or OAT6). OAT1 and OAT3 are involved in the renal elimination of endogenous and exogenous organic anions (OAs). They function as OA exchangers, coupling the uptake of OAs against an electrochemical gradient with the efflux of intracellular dicarboxylates. SLC22A20 is an OA transporter that mediates the uptake of estrone sulfate. The OAT1-like subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341004 [Multi-domain] Cd Length: 339 Bit Score: 47.03 E-value: 1.71e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 81 LGGLFFGMLGDKYGRQKILAITIVIMSISTFCIGLIPSYatigIWAPILLLLCkmaqGFSVGGEYTGASIFVAEYSPDRK 160
Cdd:cd17446 48 VGAIVFGGLSDRFGRRPLLIWSYLQMAVSGTCAAFSPSF----PIYCVFRFLT----GMALSGIVLNSVSLNVEWMPTRV 119
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 505181589 161 RGFMGSWLDFGSIAGFVMGAGVVVLISsvvgeenflDWGW-----RIPFFL 206
Cdd:cd17446 120 RAVVGTLLGYCYTLGQLILAGVAYAIR---------DWRWlqlavSLPFFI 161
|
|
| MFS_GLUT12_Class3 |
cd17435 |
Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of ... |
81-227 |
2.61e-05 |
|
Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 12 (GLUT12) is also called Solute carrier family 2, facilitated glucose transporter member 12 (SLC2A12). It is a facilitative glucose transporter, classified as a Class 3 GLUT, and is expressed in the heart, skeletal muscle, prostate, and small intestine, and is highly upregulated in breast ductal cell carcinoma. It plays a role as a secondary insulin-sensitive glucose transporter in insulin-dependent tissues. The GLUT12 subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340993 [Multi-domain] Cd Length: 376 Bit Score: 46.33 E-value: 2.61e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 81 LGGLFFGMLGDKYGRQKILAITIVIMSISTFCIGLIPSYatigiwapILLLLCKMAQGFSVGGEYTGASIFVAEYSPDRK 160
Cdd:cd17435 51 LASLTGGVLIDRYGRRTAIILTSCLLVLGSLLLVCSVSY--------TVLIVGRIAIGVSISLSSIATCVYIAEIAPQHR 122
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 505181589 161 RGFMGSWLDFGSIAGFVMGAGVVVLISSVVGeenfldwGWRIPFFLALPLGIIGLYLRHALEETPAF 227
Cdd:cd17435 123 RGLLVSLNELMIVIGILLAYISNYAFANVSN-------GWKYMFGLVIPLAALQAIAMYFLPPSPRF 182
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
81-213 |
3.57e-05 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 43.79 E-value: 3.57e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 81 LGGLFFGMLGDKYGRQKILAITIVIMSISTFCIGLIPSYATigiwapilLLLCKMAQGFSVGGEYTGASIFVAEYSPDRK 160
Cdd:TIGR00880 13 IYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITV--------LIIARFLQGFGAAFALVAGAALIADIYPPEE 84
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 505181589 161 RGFMGSWLDFGSIAGFVMGAgvvvLISSVVGEEnfldWGWRIPFFLALPLGII 213
Cdd:TIGR00880 85 RGVALGLMSAGIALGPLLGP----PLGGVLAQF----LGWRAPFLFLAILALA 129
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
299-441 |
5.04e-05 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 43.41 E-value: 5.04e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 299 LIIIAIMVGMLFVQPVIGMLSDRFGRRPfILVGSVALFTLSipAFIMINSNVIGLIFAGLLLLAVVLNCFIGVMASSLPA 378
Cdd:TIGR00880 2 LLLAGYALGQLIYSPLSGLLTDRFGRKP-VLLVGLFIFVLS--TAMFALSSNITVLIIARFLQGFGAAFALVAGAALIAD 78
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 505181589 379 MFPTHIR---FSALASAFNISVLIAgltPTLAAWLVETTqNLMMPAYYLMVIAVIGLITGL-SMKET 441
Cdd:TIGR00880 79 IYPPEERgvaLGLMSAGIALGPLLG---PPLGGVLAQFL-GWRAPFLFLAILALAAFILLAfLLPET 141
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
87-320 |
7.17e-05 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 44.92 E-value: 7.17e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 87 GMLGDKYGRQKILAITIVIMSISTFcigLIPSYATIGIWApilLLLCKMAQGFSVGGEYTGASIFVAEYSPDRKRGFMGS 166
Cdd:cd17318 77 GYLAEKYGAKRVLGYSILITALLTL---LTPLAARGGYGA---LIVLRILQGLAQGVTFPAMHALWAKWAPPLERSRLTS 150
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 167 wldfGSIAGFVMGAGVVVLISSVVGEEnfldWGWRIPFFLalpLGIIGL-------YLrhaleeTPAFqqhvdtleqgdr 239
Cdd:cd17318 151 ----IAYSGSQFGTVIAMPLSGFLCES----LGWPSIFYI---FGGLGLlwcllwfFL------VLPV------------ 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 240 eglqegpkvsfkeiatkhWRSLLTCIGlvisTNVTYYMLLTYMPSYLSHNLHYS-EDHGVLIIIAIMVGMLFVQpVIGML 318
Cdd:cd17318 202 ------------------WAIVVAHFG----HNWGFYTLLTELPTYMSDVLHFNiKSNGFLSSLPYLAMWICSI-VGGYL 258
|
..
gi 505181589 319 SD 320
Cdd:cd17318 259 AD 260
|
|
| MFS_SV2C |
cd17440 |
Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; ... |
73-168 |
7.65e-05 |
|
Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2C exhibits enriched expression in several basal ganglia nuclei, and has been found to be involved in normal operation of the basal ganglia network and could be also be involved in system adaptation in basal ganglia pathological conditions. SV2C belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340998 [Multi-domain] Cd Length: 479 Bit Score: 45.29 E-value: 7.65e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 73 SVPFLIRPLGGLFFGMLGDKYGRQKILAITIVIMSISTFCIGLIPSYAtigiwapiLLLLCKMAQGFSVGGEYTGASIFV 152
Cdd:cd17440 41 SIVYLGMMVGAFFWGGLADKVGRRQSLLICMSVNGFFAFLSSFVQGYG--------LFLFCRLLSGFGIGGAVPTVFSYF 112
|
90
....*....|....*.
gi 505181589 153 AEYSPDRKRGFMGSWL 168
Cdd:cd17440 113 AEVLAREKRGEHLSWL 128
|
|
| MFS_SV2B |
cd17438 |
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; ... |
81-168 |
8.12e-05 |
|
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2B is a key modulator of amyloid toxicity at the synaptic site and also has an essential role in the formation and maintenance of the glomerular capillary wall. SV2B belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340996 [Multi-domain] Cd Length: 477 Bit Score: 44.91 E-value: 8.12e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 81 LGGLFFGMLGDKYGRQKILAITIVIMSISTFCIGLIPSYAtigiwapiLLLLCKMAQGFSVGGEYTGASIFVAEYSPDRK 160
Cdd:cd17438 49 AGAFIWGGLADKLGRKRCLIISLAINASFAFLSSFVQGYG--------AFLFCRLISGFGIGGSLPIVFAYFSEFLAREK 120
|
....*...
gi 505181589 161 RGFMGSWL 168
Cdd:cd17438 121 RGEHLSWL 128
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
65-214 |
8.88e-05 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 44.57 E-value: 8.88e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 65 MIAALGTFSVpflirpLGGLFFGMLGDKYGRQKILAITIVIMSISTFCIGLIPsyatigiWAPILLLLCKMAQGFSVGGE 144
Cdd:cd17355 250 ALALIGLFNI------VGRLLSGWLGDRYSPRRLLAASYALRALGLALLLLLP-------FPPLALLLFAALFGLGWGAT 316
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 145 YTGASIFVAEYSPDRKRGFMGSWLDFGSIAGFVMGAGVVVLISSVVGeenfldwGWRIPFFLALPLGIIG 214
Cdd:cd17355 317 VPLTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTG-------SYTAAWALAVALGLIA 379
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
23-215 |
1.21e-04 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 44.13 E-value: 1.21e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 23 LRKAITAASLGNAMEWFdfGVYGFVAYaLGKVFFPDADPSVQMIAALGTFSVpfLIRPLGGLFFGMLGDKYGRQKILAIT 102
Cdd:cd17316 175 LRRRTLLLILLWFFISF--GYYGLTTF-LPTYLQTVLGLSPATSSLYLLLIS--LGALVGALIAGLLSDRIGRKKTLVIG 249
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 103 IVIMSIstfcigLIPSYATIGIWAPILLLLCKMAQGFSVGGEYTGASIFVAEYSPDRKRGFMGSWLDFGSIAGFVMGAGV 182
Cdd:cd17316 250 LILSGI------LALPLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPL 323
|
170 180 190
....*....|....*....|....*....|...
gi 505181589 183 VVLISSVVGeenfldwGWRIPFFLALPLGIIGL 215
Cdd:cd17316 324 IALLLASTG-------GTGVPALILALLAIVAL 349
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
44-180 |
1.42e-04 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 44.07 E-value: 1.42e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 44 YGFVAYALGKVFFPDAdpsvqMIAALgtFSVPFLIRPLGGLFFGMLGDKYGRQKILAITIVIMSISTFCIGLIPSYATIG 123
Cdd:cd17370 219 FAFLILRAQELGLSAA-----LIPLL--YALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLL 291
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 505181589 124 IwapillllckmaqGFSVGGEYTGA-----SIFVAEYSPDRKRGFMGSWLDFGS-----IAGFVMGA 180
Cdd:cd17370 292 L-------------GFILWGLYMGAqesieRAAVADLVPAELRGTAYGLFNTVVgigwlLASLIAGY 345
|
|
| PRK15402 |
PRK15402 |
MdfA family multidrug efflux MFS transporter; |
250-445 |
2.21e-04 |
|
MdfA family multidrug efflux MFS transporter;
Pssm-ID: 185300 [Multi-domain] Cd Length: 406 Bit Score: 43.39 E-value: 2.21e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 250 FKEIATKHWRSLLTCIGLVIstnvtyYMLLTY------MPSYLS--HNLHYSEDHGVLIIIAIMVGMLFVQPVIGMLSDR 321
Cdd:PRK15402 1 LSPLARLGRQALLFPLCLVL------FEFATYiandmiQPGMLAvvEDFNAGAEWVPTSMTAYLAGGMFLQWLLGPLSDR 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 322 FGRRPFILVGsVALFTLSIPAFIMINSnvIGLiFAGLLLLAVVLNCFIGVMA-SSLPAMF--PTHIRFSALASafNISVL 398
Cdd:PRK15402 75 IGRRPVMLAG-VAFFILTCLAILLAQS--IEQ-FTLLRFLQGIGLCFIGAVGyAAIQESFeeADAIKITALMA--NVALL 148
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 505181589 399 IAGLTPTLAAWLVETTQNLMMpayyLMVIAVIGLIT--GL--SMKETANRP 445
Cdd:PRK15402 149 APLLGPLVGAALIHVLPWRGM----FVLFAALAALSffGLwrAMPETAGRV 195
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
298-433 |
2.27e-04 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 43.77 E-value: 2.27e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 298 VLIIIAIMVGMLFVQPVIGMLSDRFGRRPFILVGS--------VALFTLSIPAFIMINSnVIGLIFAGllllavvlncfI 369
Cdd:cd06179 35 TWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNllgvvgsiVAGTAKSVNMLIGGQA-LIGIGAGT-----------Q 102
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 505181589 370 GVMASSLPAMFPTHIRFSALASAFNISVLIAGLTPTLAAWLVETTQNLMMPAYYLMVI----AVIGLI 433
Cdd:cd06179 103 GLGAAVASELVPNKYRGLVQGVVNLVASPGSALGPLIAGALVEANAAGWRWIFYINAIfnalALILLF 170
|
|
| MFS_SV2A |
cd17439 |
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; ... |
81-168 |
4.52e-04 |
|
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. It is unclear how SV2A is involved in correct SV function, but it has been suggested to either act as a transporter or a regulator of exocytosis by mediating Ca2+ dynamics. SV2A has been identified as the molecular target of the antiepileptic drug levetiracetam (LEV). Its expression is decreased in patients with epilepsy and in epileptic animal models. SV2A belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340997 [Multi-domain] Cd Length: 478 Bit Score: 42.71 E-value: 4.52e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 81 LGGLFFGMLGDKYGRQKILAITIVIMSISTFCIGLIPSYATigiwapilLLLCKMAQGFSVGGEYTGASIFVAEYSPDRK 160
Cdd:cd17439 49 VGAFLWGGLADRIGRRQCLLISLSVNSVFAFFSSFVQGYGT--------FLFCRLLSGVGIGGSIPIVFSYFSEFLAQEK 120
|
....*...
gi 505181589 161 RGFMGSWL 168
Cdd:cd17439 121 RGEHLSWL 128
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
81-325 |
4.92e-04 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 42.56 E-value: 4.92e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 81 LGGLFFGMLGDKYGRQKILAITIVIMSISTFCIGLIPSYATigiwapilLLLCKMAQGFSVGGEYTGASIFVAEYSPDRK 160
Cdd:cd17323 49 LGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNIAM--------LIILRFLQGFFGSSPLAIGAGTIADLFTPEE 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 161 RG-FMGSWldfgsIAGFVMGAGVVVLISSVVGEEnfldWGWRIPFFLalpLGIIGlylrhaleetpAFQQHVDTLeqgdr 239
Cdd:cd17323 121 RGkAMGVY-----SLGPLLGPALGPIIGGFITQS----LGWRWIFWF---LAIIS-----------GFCLILIFL----- 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 240 eglqegpkvSFKEIAtkhwrSLLTCIGLVistNVTYYMLLTYMPSYLSHNLHYSEDHGVLIIIAIMVGMLFVQPVIGMLS 319
Cdd:cd17323 173 ---------FLPIVL-----LLGLYVGLV---YAILYLFLTAFPYVFGEVYGFSPGEVGLMYLPIGIGALIGSIIGGRLS 235
|
....*.
gi 505181589 320 DRFGRR 325
Cdd:cd17323 236 DYYYRR 241
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
271-412 |
5.76e-04 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 42.21 E-value: 5.76e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 271 TNVTYYMLLTYMPSYLSHNLHYSEDHGVLIIIAIMVGMLFVQPVIGMLSDRFGRRPFILVGSV--ALFTLSIPAFIMINS 348
Cdd:cd17329 11 NRLGFFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLlrALGFALLGFAHSPWL 90
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 505181589 349 NVIGLIFagllllavvLNCFIGVMASSLPAMF-----PTHIR--FSALASAFNISVLIAGLtptLAAWLVE 412
Cdd:cd17329 91 FAIALVL---------TGFGGGLFEPASEAMIadvttPENRTraFSLLYWAINLGVAIGPL---LGGLLLL 149
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
254-453 |
6.59e-04 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 41.72 E-value: 6.59e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 254 ATKHWRSLLTCIGLVISTNVTYYMLLTYMPSyLSHNLHYSEDHGVLIIIAIMVGMLFVQPVIGMLSDRFGRRPFILVGsV 333
Cdd:COG0477 9 TRRRRRALLALALGTFLEGLDFTIVNVALPS-IAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIG-L 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 334 ALFTLSIpAFIMINSNVIGLIFAGLLLLAVVLNCFIGVMASsLPAMFPTHIRFSALASAFNISVLIAGLTPTLAAWLVET 413
Cdd:COG0477 87 LLFGLAS-LLCGLAPSPELLIAARALQGIGAGGLMPGALAL-IAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAA 164
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 505181589 414 TqNLMMPAYYLMVIAVIGLITGLSMKETANRPLKGATPAA 453
Cdd:COG0477 165 L-GWRWIFLINAPLGLLALVLRLRLPESRGLLLALLALAL 203
|
|
| MFS_2 |
pfam13347 |
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ... |
80-406 |
7.45e-04 |
|
MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.
Pssm-ID: 433134 [Multi-domain] Cd Length: 427 Bit Score: 41.91 E-value: 7.45e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 80 PLGGLFFGMLGDKYGRQK-ILAITIVIMSISTFCIGLIP--SYATIGIWAPILLLLCKMAQGFSvggeYTGASIFVAEYS 156
Cdd:pfam13347 51 PIVGHIIDRTRTRWGRRRpWLLLSAIILAVSFILLFTPPelGRAPLFIWLLATYILLRIAYTFF----EIPYWSLGPELT 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 157 PDRK-RGFMGSWLDFGSIAG---FVMGAGVVVLISSVVGEENFLDWGWRIPFFLALPLGIIGLYL--RHALEETPAFqqh 230
Cdd:pfam13347 127 RDYDeRTSLTSYRSFFSVGGgllAAALAFPLVLILGGTGLERKGYRIFALIGAVLMLLGVIITAAgtKERVSMRSKE--- 203
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 231 vdTLEQGDREGLQEGPKVSFKEiatKHWRSLLTCIGLV-ISTNVTYYMLLTYMPSYLSHNLHYSedhgvLIIIAIMVGML 309
Cdd:pfam13347 204 --DTGQKEAGSLLDMLKEVFRN---RAFLILLASFLLAaLAMGVLNGLLLYYFRYVLGNGFAAS-----AFPLVFTIGAL 273
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 310 FVQPVIGMLSDRFGRRPFILVGSVALFTLSIPAFIMINSNVIGLIFaglllLAVVLNCFIGVMASSLPAMFPTHIRFSAL 389
Cdd:pfam13347 274 LGIPLWPPLAKRIGKKNTYILGALITIAGFALALLLGPNNTLLFLV-----LYIIIGFGYGSSFFLPWSMLADVVDYGEL 348
|
330
....*....|....*..
gi 505181589 390 ASAFNISVLIAGLTPTL 406
Cdd:pfam13347 349 RTGKRREGTFFAMWSFI 365
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
81-355 |
7.89e-04 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 41.83 E-value: 7.89e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 81 LGGLFFGMLGDKYGRQKILAITIVIMSISTFCIGLIPSYATIGIWapilLLLCKMAQGFSvggeYTGASIFVAEYSPDRK 160
Cdd:cd17329 50 VASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIA----LVLTGFGGGLF----EPASEAMIADVTTPEN 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 161 RGFMGSWLDFGSIAGFVMGAgvvvLISSVVGEENFldwgwrIPFFLALPLGIIGLYLRHALeetpAFQQHVDTLEQGDRE 240
Cdd:cd17329 122 RTRAFSLLYWAINLGVAIGP----LLGGLLLLYSF------RLLFLAAAVLFLLAALVLLF----LLPETRPKRRAAEKT 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 241 GLQEGPKVSFKEiatkhwRSLLTCIGLVISTNVTYYMLLTYMPSYLSHNLHYSE-DHGVLIIIAIMVGMLFvQPVIGMLS 319
Cdd:cd17329 188 EILRGYKIVLRD------RAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGEsLLGLLLALNALLIVLL-QFPVARLV 260
|
250 260 270
....*....|....*....|....*....|....*.
gi 505181589 320 DRFGRRPFILVGSVaLFTLSIpAFIMINSNVIGLIF 355
Cdd:cd17329 261 ERFRLRKILMIGIL-LFAIGF-AVLAFANTLAVLIL 294
|
|
| 2A0108 |
TIGR00886 |
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions] |
84-215 |
1.65e-03 |
|
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]
Pssm-ID: 273322 [Multi-domain] Cd Length: 354 Bit Score: 40.75 E-value: 1.65e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 84 LFFGMLGDKYGRQKILAITIVIMSISTFCIGLI-PSYATigiwapilLLLCKMAQGFsVGGEYTGASIFVAEYSPDRKRG 162
Cdd:TIGR00886 55 IILGFLVDIFGPRYTTALSLLLLAIPCLWAGLAvQSYSV--------LLLIRLFIGI-AGGSFASCMPWISFFFPKKIQG 125
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 505181589 163 ----FMGSWLDFG-SIAGFVMGAgVVVLISSVVGEENFLDWGWRIPFFLALPLGIIGL 215
Cdd:TIGR00886 126 talgLAAGWGNMGgGVAQFVMPP-IIGSLIFGGGQPAHLAWGWAFVIVPAGILLLPAL 182
|
|
| MFS_SLC45_SUC |
cd17313 |
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ... |
272-355 |
1.74e-03 |
|
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340871 [Multi-domain] Cd Length: 421 Bit Score: 40.69 E-value: 1.74e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 272 NVTYYMLLTYMPSYLShNLHYSEDH-GVLIIIAIMVGMlFVQPVIGMLSDR----FGRR-PFILVGSV-ALFTLsipaFI 344
Cdd:cd17313 12 EFGWALENSYVPPILQ-TLGLSHALiGFVWTLGPILGL-FVQPLVGSLSDRcnsrIGRRrPFILVGAPlAALGL----IL 85
|
90
....*....|.
gi 505181589 345 MINSNVIGLIF 355
Cdd:cd17313 86 IPNAADIGLAL 96
|
|
| MFS_YdiM_like |
cd17396 |
Inner membrane transport protein YdiM and similar proteins of the Major Facilitator ... |
297-342 |
2.22e-03 |
|
Inner membrane transport protein YdiM and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily contains Escherichia coli inner membrane transport proteins YdiM and YdiN, which belong to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340954 [Multi-domain] Cd Length: 384 Bit Score: 40.41 E-value: 2.22e-03
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 505181589 297 GVLIIIA-IMVGMLFVQPVIGMLSDRFGRRPFILVGSV--ALFTLSIPA 342
Cdd:cd17396 36 GVAYVISgIGIGRLLTILFAGVLSDKFGRKPSVLLGMVlyALFFVGILF 84
|
|
| MFS_OAT |
cd17374 |
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ... |
80-206 |
2.50e-03 |
|
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340932 [Multi-domain] Cd Length: 341 Bit Score: 39.97 E-value: 2.50e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 80 PLGGLFFGMLGDKYGRQKILAITIVIMSISTFCIGLIPSYatigiwaPILLLLcKMAQGFSVGGEYTGASIFVAEYSPDR 159
Cdd:cd17374 49 LVGALIFGHLSDRFGRKFILLLSLLQLAIFGTCAAFAPTF-------PVYCVL-RFLAGFAVSGISINTLILGTEWTTPR 120
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 505181589 160 KRGFMGSWLDFGSIAGFVMGAGVVVLISsvvgeenflDWGW-----RIPFFL 206
Cdd:cd17374 121 HRALAITLTSCFFSIGQMLLAGLAYAIR---------DWRLlqlvvSVPFFL 163
|
|
| MFS_SV2 |
cd17363 |
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic ... |
81-168 |
3.01e-03 |
|
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. The SV2 family belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340921 [Multi-domain] Cd Length: 474 Bit Score: 40.16 E-value: 3.01e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 81 LGGLFFGMLGDKYGRQKILAITIVIMSISTFCIGLIPSYATigiwapilLLLCKMAQGFSVGGEYTGASIFVAEYSPDRK 160
Cdd:cd17363 49 VGAFVWGGLADKLGRKQCLLIALSVNGVFAFLSSFVQGYGF--------FLFCRLLSGIGIGGSIPIVFSYFAEFLAREK 120
|
....*...
gi 505181589 161 RGFMGSWL 168
Cdd:cd17363 121 RGEHLSWL 128
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
257-413 |
3.51e-03 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 39.47 E-value: 3.51e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 257 HWRSLLTCIGLVISTNVTYYMLLTYMPsYLSHNLHYSEDHGVLIIIAIMVGMLFVQPVIGMLSDRFGRRPFILVGsVALF 336
Cdd:COG2271 8 RWRILALLFLAYFLNYLDRSNLSVAAP-PLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIG-LLLW 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 337 TLSIPAFIMINSnvIGLIFAGLLLLAVVLNCFIGVMASSLPAMFPTHIR---FSALASAFNISVLIAGLtptLAAWLVET 413
Cdd:COG2271 86 GLATLLFGFATS--FWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERgraLGIFNAGGPLGGALAPP---LLGWLLAA 160
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
261-339 |
3.57e-03 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 39.48 E-value: 3.57e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 505181589 261 LLTCIGLVISTNVTYYMLLTYMPSyLSHNLHYSEDHGVLIIIAIMVGMLFVQPVIGMLSDRFGRRPFILVGsVALFTLS 339
Cdd:cd17320 1 LLLLALLVALGPLAIDMYLPALPA-IARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAG-LLLFILA 77
|
|
| xylE |
PRK10077 |
D-xylose transporter XylE; Provisional |
81-335 |
3.89e-03 |
|
D-xylose transporter XylE; Provisional
Pssm-ID: 182225 [Multi-domain] Cd Length: 479 Bit Score: 39.68 E-value: 3.89e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 81 LGGLFFGMLGDKYGRQKILAITIVIMSIStfciGLIPSY-----ATIGIWAPILLL---LCKMAQGFSVGGEYTGASIFV 152
Cdd:PRK10077 70 IGGALGGYCSNRFGRRDSLKIAAVLFFIS----ALGSAWpefgfTSIGPDNTGYVPefvIYRIIGGIGVGLASMLSPMYI 145
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 153 AEYSPDRKRGFMGSWLDFGSIAGFVMGAGVVVLISSVVGEENFLDWGWRIPFFL-ALPLGIIGLYL------------RH 219
Cdd:PRK10077 146 AEIAPAHIRGKLVSFNQFAIIFGQLVVYFVNYFIARSGDASWLNTDGWRYMFASeAIPALLFLMLLyfvpetprylmsRG 225
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 220 ALEETPAFQQHVDTLEQGDREgLQEgPKVSFKEIATKHWR-----SLLTCIGLVIST-------NVTYYmlltYMPSYLS 287
Cdd:PRK10077 226 KQEQAEGILRKIMGNTLATQA-LQE-IKHSLDHGRKTGGKllmfgVGVIVIGVMLSVfqqfvgiNVVLY----YAPEIFK 299
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 505181589 288 hNLHYSEDHGVL-IIIAIMVGMLFVqpVIGMLS-DRFGRRPFILVGSVAL 335
Cdd:PRK10077 300 -TLGASTDIALLqTIIVGVINLTFT--VLAIMTvDKFGRKPLQIIGALGM 346
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
81-219 |
3.99e-03 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 39.49 E-value: 3.99e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 81 LGGLFFGMLGDKYGRQKILAITIVIMSISTFCIGLIPSyatigiwAPILLLLCKMAQGFSVGGEYTGASIFVAEYSPDRK 160
Cdd:cd17365 221 IGSLLLGWLADRFGPKRVLALFFALGAVSLALLGVSPA-------SLVLLYVLVFLAGACVNGAQVGLYALAARFYPTEV 293
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 505181589 161 R----GFMGSWLDFGSIAGFVMGAgvvVLISSVVG-EENFLDWGwrIPFFLALpLGIIGLYLRH 219
Cdd:cd17365 294 RatgvGWALGVGRLGAILGPLLGG---LLLAAGLGpESVFLALA--IPAALGA-LAVLLLRLRR 351
|
|
| MFS_SLC37A3 |
cd17342 |
Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters; Solute ... |
55-353 |
5.13e-03 |
|
Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 3 (SLC37A3) is also called sugar phosphate exchanger 3 (SPX3), and is one of four SLC37 family proteins in vertebrates. It's function and activity is unknown. The best characterized SLC37 family member is SLC37A4, also called the glucose-6-phosphate transporter (G6PT), a phosphate (Pi)-linked G6P antiporter. SLC37A3 is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340900 [Multi-domain] Cd Length: 399 Bit Score: 39.22 E-value: 5.13e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 55 FFPDADpSVQMIaaLGTFSVPFLIRPLGGLFF-GMLGDKYGRQKILAITIVIMSISTFCIGLIPSYatIGIWAPILLLLC 133
Cdd:cd17342 54 LFPSQD-DAALF--LGVLDTIFLFSYAIGLFIsGWLGDRLNLRLVLAFGMCSSAITVFLFGVLTEW--LHFYNKYLYCIL 128
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90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 134 KMAQGFSvggEYTGASIFVAeyspdrkrgFMGSWldFGSIA-GFVMG-----AGV-----VVLISSVvgeenfLDWGWRI 202
Cdd:cd17342 129 WVLNGLL---QSTGWPCVVA---------IMGNW--FGKSSrGFVLGlwsacASVgniigALLASSV------LDYGYEY 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 203 PF-FLALPLGIIGLYLRHALEETPafqqhvdtleqgdreglqegPKVSFKEIAtkhwrslLTCIGLVistNVTYYMLLTY 281
Cdd:cd17342 189 AFlVTSSLLFAGAIVVFFGLLSSP--------------------PGVIPYSLA-------YACLKLV---NYSFFFWLPF 238
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250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 505181589 282 mpsYLSHNLHYSEDHGVLIIIAIMVGMLFVQPVIGMLSDRFGRR-----PFILVGSVALFTLS-IPAFIMINSNVIGL 353
Cdd:cd17342 239 ---YLSNNFHWKESEADQLSIWYDVGGIIGGIVAGYISDRMGSRspvvvVMLLLAIPSLFVYShSPSDKVLNAFVMTI 313
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|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
277-433 |
6.30e-03 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 38.71 E-value: 6.30e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 277 MLLTYMPSYLSHNLHYSEDHGV--LIIIAIMVGMLFVQPVIGMLSDRFGRRPFILVGSVA------LFTLSIPAFIMINS 348
Cdd:cd17330 14 IVFPVLPFYVREFNKLGASGYYvgLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGsavsyvLLGLSRNLWLLFLA 93
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90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 349 NVIGLIFagllllavvlNCFIGVMASSLPAMFPTH---IRFSALASAFNISVLIAgltPTLAAWLVeTTQNLMMPAYYLM 425
Cdd:cd17330 94 RFLDGLT----------GGNVSVAQAYIADITDEEeraKAFGIISAAFGLGFILG---PALGGFLS-TPYGYALPFLVAA 159
|
....*...
gi 505181589 426 VIAVIGLI 433
Cdd:cd17330 160 ALALLNLV 167
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|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
69-349 |
6.86e-03 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 38.79 E-value: 6.86e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 69 LGTFSVPFLIRPLGGLF-FGMLGDKYGRQKILAITIVIMSISTFCIGLIPSYATIGIwapiLLLLCKMAQGFSVGGeytG 147
Cdd:cd17312 40 LGIIGSAFLIAYAVGKFiSGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWFFAV----LWGLNGLFQSMGWPP---C 112
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90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 148 ASIFVAEYSPDRKRGFMGSWLDFGSIAGFVMGAGVVVLISSVvgeenfldwGWRIPFFLAlplGIIGLYlrhaleetpaf 227
Cdd:cd17312 113 VKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYY---------GWRAAFLVP---GIVGLV----------- 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 228 qqhvdtleqgdreglqeGPKVSFKEIATKHWRSLLTCIGLVIsTNVTYYMLLTYMPSYLSHNLHYSEDHGVLIIIAIMVG 307
Cdd:cd17312 170 -----------------VAIILFFFLRDSPPYVWVLSLAYAF-VYIVRYACLDWGPLYLYEVKGYSLIDAGWFSSLYEVG 231
|
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 505181589 308 MLFVQPVIGMLSDRF--GRRPFILVGSVALFTLSIPAFIMINSN 349
Cdd:cd17312 232 GIAGTILAGLLSDKLfgGRRAPIAVIYMLLMTLSLALFWFFPHN 275
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|
| MFS_STP |
cd17361 |
Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; ... |
29-231 |
8.56e-03 |
|
Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; The plant Sugar transport protein (STP) subfamily includes STP1-STP14; they are also called hexose transporters. They mediate the active uptake of hexoses such as glucose, 3-O-methylglucose, fructose, xylose, mannose, galactose, fucose, 2-deoxyglucose and arabinose, by sugar/hydrogen symport. Several STP family transporters are expressed in a tissue-specific manner, or at specific developmental stages. STP1 is the member with the highest expression level of all members and high expression is detected in photosynthetic tissues, such as leaves and stems, while roots, siliques, and flowers show lower expression levels. It plays a major role in the uptake and response of Arabidopsis seeds and seedlings to sugars. The STP subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340919 [Multi-domain] Cd Length: 390 Bit Score: 38.39 E-value: 8.56e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 29 AASLGNAMEWFDFGVYGFVAY--ALGKVFFPD----------------ADPSVQmiaaLGTfSVPFLIRPLGGLFFGMLG 90
Cdd:cd17361 1 VAALGGLIFGYDIGISGGVTSmdPFLEKFFPSvyekkkgasennyckyDDQLLQ----LFT-SSLYLAGLVASLLASYVT 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 91 DKYGRQkilaITIVIMSIStFCIGLIPSYATIGIWApilLLLCKMAQGFSVGGEYTGASIFVAEYSPDRKRGFMgswldf 170
Cdd:cd17361 76 RKWGRK----PSMLIGGVL-FLVGAALNAAAQNIAM---LIVGRILLGFGVGFGNQAVPLYLSEMAPAKLRGAL------ 141
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 505181589 171 gsIAGFVMGAGVVVLISSVV--GEENFLDWGWRIPFFLALPLGIIGLYLRHALEETPAFQQHV 231
Cdd:cd17361 142 --NIGFQLAITIGILIANLInyGTSKIKPNGWRLSLGLAAVPALILLLGSLFLPETPNSPQLV 202
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|
| MFS_SLC22A1_2_3 |
cd17379 |
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, ... |
81-165 |
9.99e-03 |
|
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, and 3) of the Major Facilitator Superfamily of transporters; This sufamily includes solute carrier family 22 member 1 (SLC22A1, also called organic cation transporter 1 or OCT1), SLC22A2 (or OCT2), SLC22A3 (or OCT3), and similar proteins. OCT1-3 have similar basic functional properties: they are able to translocate a variety of structurally different organic cations in both directions across the plasma membrane; to translocate organic cations independently from sodium, chloride or proton gradients; and to function as electrogenic uniporters for cations or as electroneutral cation exchangers. They show overlapping but distinct substrate and inhibitor specificities, and different tissue expression pattern. In humans, OCT1 is strongly expressed in the liver, OCT2 is highly expressed in the kidney where it is localized at the basolateral membrane of renal proximal tubules, and OCT3 is most strongly expressed in skeletal muscle. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. The SLC22A1-3 subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340937 [Multi-domain] Cd Length: 340 Bit Score: 38.10 E-value: 9.99e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505181589 81 LGGLFFGMLGDKYGRQKILAITIVIMSISTFCIGLIPSYatigiwapILLLLCKMAQGFSVGGEYTGASIFVAEYSPDRK 160
Cdd:cd17379 48 IGSIVIGYLADRFGRKVCFLISILGNGVSGVLMAFSPNY--------PWFLIFRFLQGLFGKGGWMTGYVLVTEFVGSKY 119
|
....*
gi 505181589 161 RGFMG 165
Cdd:cd17379 120 RRTVG 124
|
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