|
Name |
Accession |
Description |
Interval |
E-value |
| 2A0110 |
TIGR00889 |
nucleoside transporter; This family of proteins transports nucleosides at a high affinity. The ... |
1-414 |
0e+00 |
|
nucleoside transporter; This family of proteins transports nucleosides at a high affinity. The transport mechanism is driven by proton motive force. This family includes nucleoside permease NupG and xanthosine permease from E.Coli. [Transport and binding proteins, Nucleosides, purines and pyrimidines]
Pssm-ID: 129967 [Multi-domain] Cd Length: 418 Bit Score: 571.05 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505182616 1 MNLKLQLKILSFLQFCLWGSWLTTLGSYMFVTLKFDGAAIGAVYSSLGIAAVLMPTLLGIVADKWISAKWVYAICHLVGA 80
Cdd:TIGR00889 1 MKTTAKLKFMSFLQWFIWGSWLVTLGSYMSKTLHFSGAEIGWVYSSTGIAAILMPILVGIIADKWLSAQKVYAVCHFAGA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505182616 81 LTLYLAAQVTTPGEMFLVILLNSLAYMPTLGLINTISYYRLQSAGLDIVTDFPPIRIWGTIGFILAMWGVSFSGFELSHM 160
Cdd:TIGR00889 81 LLLFFAAQVTTPAGMFPVLLANSLAYMPTIALTNSISYANLPQAGLDVVTDFPPIRVMGTIGFIAAMWAVSLLDIELSNI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505182616 161 QLYIGATLSVLLALFTLTLPHIPVANAQRNQSWTEMLGLNAFALFKNKRMAIFFIFSMMLGAELQITNMFGNTFLHSFDK 240
Cdd:TIGR00889 161 QLYITAGSSALLGVFALTLPDIPVAKSTAKMSIKVMLGLDAFILFKNKRMAIFFFFSMLLGAPLQITNIFGNGFLHEFGR 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505182616 241 DPLFSGSFIVEHASVLMSISQISETLFILTIPFFLSRYGIKNVMLISIVAWMLRFGLFAFGDPTPFGTVLLVLSMIVYGC 320
Cdd:TIGR00889 241 NPEFADSFVVKNASIWMSLSQFSEIFFILTIPFFLKRFGIKKVMLLSLVAWALRFGFFAYGDPEYFGYALLFLSMIVYGC 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505182616 321 AFDFFNISGSVFVEKEVRPEIRASAQGMFLMMTNGFGCILGGMVSGKVVEHFTVEGITNWQSVWLIFAAYSLVLAVAFVA 400
Cdd:TIGR00889 321 AFDFFNISGSVFVEKEVPVHIRASAQGLFTLMCNGFGSLLGYILSGVMVEKMFAYGTFDWQTMWLFFAGYIAILAVLFMI 400
|
410
....*....|....
gi 505182616 401 LFKYQHVRQPTAAR 414
Cdd:TIGR00889 401 FFKYSHNAIKVDDR 414
|
|
| MFS_NHS |
cd06177 |
Nucleoside:H(+) symporter family of the Major Facilitator Superfamily of transporters; The ... |
6-403 |
2.79e-177 |
|
Nucleoside:H(+) symporter family of the Major Facilitator Superfamily of transporters; The prototypical members of the Nucleoside:H(+) symporter (NHS) family are Escherichia coli nucleoside permease NupG and xanthosine permease. Nucleoside:H(+) symporters are proton-driven transporters that facilitate the import of nucleosides across the cytoplasmic membrane. NupG is a broad-specificity transporter of purine and pyrimidine nucleosides. Xanthosine permease is involved in the uptake of xanthosine and other nucleosides such as inosine, adenosine, cytidine, uridine and thymidine. The NHS family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340866 [Multi-domain] Cd Length: 386 Bit Score: 499.46 E-value: 2.79e-177
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505182616 6 QLKILSFLQFCLWGSWLTTLGSYMFVTLKFDGAAIGAVYSSLGIAAVLMPTLLGIVADKWISAKWVYAICHLVGALTLYL 85
Cdd:cd06177 1 RLSVMMFLQFFIWGAWLVTLGGYMGSTLGFTGAQIGAVYSTTGIAAIIMPFFLGIIADRFFAAEKVLAVLHLIGAAALFY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505182616 86 AAQVTTPGEMFLVILLNSLAYMPTLGLINTISYYRLQSAgldiVTDFPPIRIWGTIGFILAMWGVSFSGFELSHMQLYIG 165
Cdd:cd06177 81 AATVTDFSVFFWVMLLYSLCYMPTLALTNSIAFSNLEDP----VKDFPPIRVWGTIGWIAAGWPVGFLGWEASNLQFYIA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505182616 166 ATLSVLLALFTLTLPHIPVANAQRNQSWTEMLGLNAFALFKNKRMAIFFIFSMMLGAELQITNMFGNTFLHSFDkdplfs 245
Cdd:cd06177 157 AGASLLLGLYSLTLPHTPPKKAGKGVSKRSLLGLDAFVLLKNPFFAVFFIFSFLLGAPLQFYYTFANPFLNDFG------ 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505182616 246 gsFIVEHASVLMSISQISETLFILTIPFFLSRYGIKNVMLISIVAWMLRFGLFAFGDPTPfGTVLLVLSMIVYGCAFDFF 325
Cdd:cd06177 231 --MIVKNPAGIMSLGQISEILFMLAIPFFLKRLGIKKVMLIGMLAWVLRFGLFAYGDPSP-GVWMLVLSIILHGVCYDFF 307
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 505182616 326 NISGSVFVEKEVRPEIRASAQGMFLMMTNGFGCILGGMVSGKVVEHFT-VEGITNWQSVWLIFAAYSLVLAVAFVALFK 403
Cdd:cd06177 308 FVTGYIYVDKKAPKDIRASAQGLFMLMTNGVGALVGSILSGKVVDKFTtVEGTKDWQTIWLVPAIYALVLAILFALFFR 386
|
|
| Nuc_H_symport |
pfam03825 |
Nucleoside H+ symporter; |
1-406 |
2.39e-172 |
|
Nucleoside H+ symporter;
Pssm-ID: 461066 [Multi-domain] Cd Length: 399 Bit Score: 487.74 E-value: 2.39e-172
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505182616 1 MNLKLQLKILSFLQFCLWGSWLTTLGSYMFVTLkFDGAAIGAVYSSLGIAAVLMPTLLGIVADKWISAKWVYAICHLVGA 80
Cdd:pfam03825 1 MNTKLRLKVMMFLQFFIWGAWLVTLGSYMFVTG-FDGASIGAVYSSLGIAAIFMPALLGIIADRWFSAERVLAVCHLIGA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505182616 81 LTLYLAAQVTTPGEMFLVILLNSLAYMPTLGLINTISYYRLQsaglDIVTDFPPIRIWGTIGFILA-----MWGVSFSGF 155
Cdd:pfam03825 80 ITLFMAAQVTTFEAFFLVILVNSLAYMPTLALTNSIAFANLQ----DPVTDFPPIRVWGTIGWIMAswpfvMWVVSLAGF 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505182616 156 ELSHMQLYIGATLSVLLALFTLTLPHIPvANAQRNQSWTEMLGLNAFALFKNKRMAIFFIFSMMLGAELQITNMFGNTFL 235
Cdd:pfam03825 156 ELSHMQLLIAAGLSALLVLFALTLPHTP-AKQKANQSWTTLLGLDAFALLKNKRMAVFFIFSFLLGAELQIYNVFANTFL 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505182616 236 HSFDKdplfsgsFIVEHASVLMSISQISETLFILTIPFFLSRYGIKNVMLISIVAWMLRFGLFAFG-DPTPFGTVLLVLS 314
Cdd:pfam03825 235 TSFDK-------FIVKHASIIMSLGQISEILFMLTLPFFLKRFGIKNVMLIGIVAWALRFAFFAYGaDPTPFGTALLLLS 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505182616 315 MIVYGCAFDFFNISGSVFVEKEVRPEIRASAQGMFLMMTNGFGCILGGMVSGKVVEHFTVEGITNWQSVWLIFAAYSLVL 394
Cdd:pfam03825 308 MIVHGVAYDFFNITGYIFVDKEVPPAIRASAQGLFLLMTNGFGCILGSILSGMVVEMFTQDGITDWQTVWLVFAGMALVL 387
|
410
....*....|..
gi 505182616 395 AVAFVALFKYQH 406
Cdd:pfam03825 388 AVLFMAFFRYKH 399
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
135-404 |
1.33e-05 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 47.20 E-value: 1.33e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505182616 135 IRIWGTIGFILAMWGV-----SFSGFELSHMQL--YIGATLSVLLALFTLTLPHIPVANAQRNQSWTEMLGlnafALFKN 207
Cdd:COG2211 152 RFAFAGLGGLLASVLPpplvaAFGGDAALGYRLtaLIFAVLGLLAFLLTFFGTKERPVPEEEKVSLKESLK----ALLKN 227
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505182616 208 KRMAIFFIFSMMLGAELQITNMFGNTFLHSFDKDPlfsgsfiVEHASVLMSISQISETLFILTIPFFLSRYGIKNVMLIS 287
Cdd:COG2211 228 RPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLS-------AALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIG 300
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505182616 288 IVAWMLRFGLFAFGDPTPFgtVLLVLSMIVYGCAFDFFNISGSVFV-----EKEVRPEIRASAQGM-FLMMTNGFGCILG 361
Cdd:COG2211 301 LLLAALGLLLLFFLGPGNL--WLLLVLAALAGIGLGAILVLPWAMLadvvdYDEWKTGRRREGLYFgIFTFAIKLGQALA 378
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 505182616 362 GMVSGKVVEH--FTVEGITNWQSVWLIFAAYSLV----LAVAFVALFKY 404
Cdd:COG2211 379 GALAGLLLALfgYVAGAAQSPSALTGIRLLFFLLpavlLLLAALLLLFY 427
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| 2A0110 |
TIGR00889 |
nucleoside transporter; This family of proteins transports nucleosides at a high affinity. The ... |
1-414 |
0e+00 |
|
nucleoside transporter; This family of proteins transports nucleosides at a high affinity. The transport mechanism is driven by proton motive force. This family includes nucleoside permease NupG and xanthosine permease from E.Coli. [Transport and binding proteins, Nucleosides, purines and pyrimidines]
Pssm-ID: 129967 [Multi-domain] Cd Length: 418 Bit Score: 571.05 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505182616 1 MNLKLQLKILSFLQFCLWGSWLTTLGSYMFVTLKFDGAAIGAVYSSLGIAAVLMPTLLGIVADKWISAKWVYAICHLVGA 80
Cdd:TIGR00889 1 MKTTAKLKFMSFLQWFIWGSWLVTLGSYMSKTLHFSGAEIGWVYSSTGIAAILMPILVGIIADKWLSAQKVYAVCHFAGA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505182616 81 LTLYLAAQVTTPGEMFLVILLNSLAYMPTLGLINTISYYRLQSAGLDIVTDFPPIRIWGTIGFILAMWGVSFSGFELSHM 160
Cdd:TIGR00889 81 LLLFFAAQVTTPAGMFPVLLANSLAYMPTIALTNSISYANLPQAGLDVVTDFPPIRVMGTIGFIAAMWAVSLLDIELSNI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505182616 161 QLYIGATLSVLLALFTLTLPHIPVANAQRNQSWTEMLGLNAFALFKNKRMAIFFIFSMMLGAELQITNMFGNTFLHSFDK 240
Cdd:TIGR00889 161 QLYITAGSSALLGVFALTLPDIPVAKSTAKMSIKVMLGLDAFILFKNKRMAIFFFFSMLLGAPLQITNIFGNGFLHEFGR 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505182616 241 DPLFSGSFIVEHASVLMSISQISETLFILTIPFFLSRYGIKNVMLISIVAWMLRFGLFAFGDPTPFGTVLLVLSMIVYGC 320
Cdd:TIGR00889 241 NPEFADSFVVKNASIWMSLSQFSEIFFILTIPFFLKRFGIKKVMLLSLVAWALRFGFFAYGDPEYFGYALLFLSMIVYGC 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505182616 321 AFDFFNISGSVFVEKEVRPEIRASAQGMFLMMTNGFGCILGGMVSGKVVEHFTVEGITNWQSVWLIFAAYSLVLAVAFVA 400
Cdd:TIGR00889 321 AFDFFNISGSVFVEKEVPVHIRASAQGLFTLMCNGFGSLLGYILSGVMVEKMFAYGTFDWQTMWLFFAGYIAILAVLFMI 400
|
410
....*....|....
gi 505182616 401 LFKYQHVRQPTAAR 414
Cdd:TIGR00889 401 FFKYSHNAIKVDDR 414
|
|
| MFS_NHS |
cd06177 |
Nucleoside:H(+) symporter family of the Major Facilitator Superfamily of transporters; The ... |
6-403 |
2.79e-177 |
|
Nucleoside:H(+) symporter family of the Major Facilitator Superfamily of transporters; The prototypical members of the Nucleoside:H(+) symporter (NHS) family are Escherichia coli nucleoside permease NupG and xanthosine permease. Nucleoside:H(+) symporters are proton-driven transporters that facilitate the import of nucleosides across the cytoplasmic membrane. NupG is a broad-specificity transporter of purine and pyrimidine nucleosides. Xanthosine permease is involved in the uptake of xanthosine and other nucleosides such as inosine, adenosine, cytidine, uridine and thymidine. The NHS family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340866 [Multi-domain] Cd Length: 386 Bit Score: 499.46 E-value: 2.79e-177
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505182616 6 QLKILSFLQFCLWGSWLTTLGSYMFVTLKFDGAAIGAVYSSLGIAAVLMPTLLGIVADKWISAKWVYAICHLVGALTLYL 85
Cdd:cd06177 1 RLSVMMFLQFFIWGAWLVTLGGYMGSTLGFTGAQIGAVYSTTGIAAIIMPFFLGIIADRFFAAEKVLAVLHLIGAAALFY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505182616 86 AAQVTTPGEMFLVILLNSLAYMPTLGLINTISYYRLQSAgldiVTDFPPIRIWGTIGFILAMWGVSFSGFELSHMQLYIG 165
Cdd:cd06177 81 AATVTDFSVFFWVMLLYSLCYMPTLALTNSIAFSNLEDP----VKDFPPIRVWGTIGWIAAGWPVGFLGWEASNLQFYIA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505182616 166 ATLSVLLALFTLTLPHIPVANAQRNQSWTEMLGLNAFALFKNKRMAIFFIFSMMLGAELQITNMFGNTFLHSFDkdplfs 245
Cdd:cd06177 157 AGASLLLGLYSLTLPHTPPKKAGKGVSKRSLLGLDAFVLLKNPFFAVFFIFSFLLGAPLQFYYTFANPFLNDFG------ 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505182616 246 gsFIVEHASVLMSISQISETLFILTIPFFLSRYGIKNVMLISIVAWMLRFGLFAFGDPTPfGTVLLVLSMIVYGCAFDFF 325
Cdd:cd06177 231 --MIVKNPAGIMSLGQISEILFMLAIPFFLKRLGIKKVMLIGMLAWVLRFGLFAYGDPSP-GVWMLVLSIILHGVCYDFF 307
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 505182616 326 NISGSVFVEKEVRPEIRASAQGMFLMMTNGFGCILGGMVSGKVVEHFT-VEGITNWQSVWLIFAAYSLVLAVAFVALFK 403
Cdd:cd06177 308 FVTGYIYVDKKAPKDIRASAQGLFMLMTNGVGALVGSILSGKVVDKFTtVEGTKDWQTIWLVPAIYALVLAILFALFFR 386
|
|
| Nuc_H_symport |
pfam03825 |
Nucleoside H+ symporter; |
1-406 |
2.39e-172 |
|
Nucleoside H+ symporter;
Pssm-ID: 461066 [Multi-domain] Cd Length: 399 Bit Score: 487.74 E-value: 2.39e-172
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505182616 1 MNLKLQLKILSFLQFCLWGSWLTTLGSYMFVTLkFDGAAIGAVYSSLGIAAVLMPTLLGIVADKWISAKWVYAICHLVGA 80
Cdd:pfam03825 1 MNTKLRLKVMMFLQFFIWGAWLVTLGSYMFVTG-FDGASIGAVYSSLGIAAIFMPALLGIIADRWFSAERVLAVCHLIGA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505182616 81 LTLYLAAQVTTPGEMFLVILLNSLAYMPTLGLINTISYYRLQsaglDIVTDFPPIRIWGTIGFILA-----MWGVSFSGF 155
Cdd:pfam03825 80 ITLFMAAQVTTFEAFFLVILVNSLAYMPTLALTNSIAFANLQ----DPVTDFPPIRVWGTIGWIMAswpfvMWVVSLAGF 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505182616 156 ELSHMQLYIGATLSVLLALFTLTLPHIPvANAQRNQSWTEMLGLNAFALFKNKRMAIFFIFSMMLGAELQITNMFGNTFL 235
Cdd:pfam03825 156 ELSHMQLLIAAGLSALLVLFALTLPHTP-AKQKANQSWTTLLGLDAFALLKNKRMAVFFIFSFLLGAELQIYNVFANTFL 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505182616 236 HSFDKdplfsgsFIVEHASVLMSISQISETLFILTIPFFLSRYGIKNVMLISIVAWMLRFGLFAFG-DPTPFGTVLLVLS 314
Cdd:pfam03825 235 TSFDK-------FIVKHASIIMSLGQISEILFMLTLPFFLKRFGIKNVMLIGIVAWALRFAFFAYGaDPTPFGTALLLLS 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505182616 315 MIVYGCAFDFFNISGSVFVEKEVRPEIRASAQGMFLMMTNGFGCILGGMVSGKVVEHFTVEGITNWQSVWLIFAAYSLVL 394
Cdd:pfam03825 308 MIVHGVAYDFFNITGYIFVDKEVPPAIRASAQGLFLLMTNGFGCILGSILSGMVVEMFTQDGITDWQTVWLVFAGMALVL 387
|
410
....*....|..
gi 505182616 395 AVAFVALFKYQH 406
Cdd:pfam03825 388 AVLFMAFFRYKH 399
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
7-401 |
5.60e-20 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 90.72 E-value: 5.60e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505182616 7 LKILSFLQFCLWGSWLTTLGSYmFVTLKFDGAAIGAVYSSLGIAAVLMPTLLGIVADKWISAKWVYAICHLVGAL-TLYL 85
Cdd:cd17335 2 LKLFYFFFFAALGSLLPFLSVY-LKQLGLSPTQIGILIGIRPFVRFLSAPLWGALADRFGKRKALLLLSLLAAVLfFLSL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505182616 86 AAQVTTPGEMFLVILLNSLAYMPTLGLINTISYYRLQSAGLDivtdFPPIRIWGTIGFILAM----WGVSFSGFELSHMQ 161
Cdd:cd17335 81 FFVAQIFWLLLLLVILGAFFSAPVVPLVDSITLQYLGEERER----YGKQRLWGSIGFGIAAllvgILIDRSSTYKNYTI 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505182616 162 LYIGATLSVLLALFTLTLPHIPVANAQRNQSWTEMLglnafALFKNKRMAIFFIFSMMLGaelqITNMFGNTFLHSFDKD 241
Cdd:cd17335 157 AFYVFAVLMLLALLLALKFPFRPKHPEPNENTGGLL-----ALLRNPRVLAFLLVAFLMG----FGHGLIYSFLFWHLQD 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505182616 242 PLFSGSFIvehaSVLMSISQISETLFILTIPFFLSRYGIKNVMLISIVAWMLRFGLFAFGdPTPFgtvLLVLSMIVYGCA 321
Cdd:cd17335 228 LGGSKTLI----GLLWTVGVVSEIPFFFFSSRLIQRFGHVGLLYLGLLAYVVRWLLYSFL-ENPW---LVLPIELLHGLT 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505182616 322 FDFFNISGSVFVEKEVRPEIRASAQGMFLMMTNGFGCILGGMVSGKVVEHFTVegitnwQSVWLIFAAYSLVLAVAFVAL 401
Cdd:cd17335 300 FALVWAAAVSYASAAAPPGLRATAQGLLQGLYFGLGGGLGSLIGGYLYEAFGA------RTTFRFFAIAALAGLLAFFLI 373
|
|
| MFS_1_like |
pfam12832 |
MFS_1 like family; This family contains proteins related to the MFS superfamily. |
5-373 |
1.83e-19 |
|
MFS_1 like family; This family contains proteins related to the MFS superfamily.
Pssm-ID: 432817 [Multi-domain] Cd Length: 362 Bit Score: 89.23 E-value: 1.83e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505182616 5 LQLKILSFLQFCLWGSWLTTLGSYMfVTLKFDGAAIGAVYSSLGIAAVLMPTLLGIVADKWISAKWVYAIChLVGALTLY 84
Cdd:pfam12832 2 WRLKGFYFFYFAALGCLLPYWGLYL-RSIGLNPSEIGLITAILPLTRILAPPIWGWLADRTGKRKAVVRLA-SILAAVLF 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505182616 85 LAAQVTTPGE----MFLVILLNSLAYMPTLGLINTISYYRLQSAGldivTDFPPIRIWGTIGFILAMWGVSFSgFELSHM 160
Cdd:pfam12832 80 LSVLFIPISLtfwwLALLVVLFSFFWNAILPQFEVATLQHLGEKR----KDYGRQRLWGSVGFALSVFGLGAL-FDHYSV 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505182616 161 QLYIGATLSVLLALFTLTLPhIPVANAQRNQSWTEMLGLNAFALFKNKRMAIFFIFSMMLGaelqITNMFGNTFLHSFDK 240
Cdd:pfam12832 155 GLLPSVLFYLFAALMLLSLL-LPLAPPEMEYESKGGSKAVFWNLLKQPEVIIFFLAAFLLG----FSHGPFYTFLFLYLE 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505182616 241 DPLFSGSFIvehaSVLMSISQISETLFILTIPFFLSRYGIKNVMLISIVAWMLRFGLFAFGDPTPfgtVLLVLSMIVYGC 320
Cdd:pfam12832 230 NLGASNTLL----GALWALGVVAEIPLFFYAHRLLRRFGHRNLLIIALLLTALRWLLYAFFVENP---WLVLPIQFLHAI 302
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 505182616 321 AFDFFNISGSVFVEKEVRPEIRASAQGMFLMMTNGFGCILGGMVSGKVVEHFT 373
Cdd:pfam12832 303 SFGLTHAAAIEYVRRIFPGSLQGTGQALYSGLYFGLGGALGSLIGGQLWDLFG 355
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
7-399 |
2.98e-11 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 64.37 E-value: 2.98e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505182616 7 LKILSFLQFCLWGSWLTTLGSYMfVTLKFDGAAIGAVYSSLGIAAVLMPTLLGIVADKWiSAKWVYAICHLVGALTLYLA 86
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALL-QSFGLSASQLGLLFALFSLGYALLQPLAGLLADRF-GRRPVLLLGLLLFALGALLF 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505182616 87 AQVTTPGEMFLVILLNSLAYMPTLGLINTISYYRLQSAGLDIVTDFP--PIRIWGTIGFILAMWGVSFSGFELsHMQLYI 164
Cdd:cd06174 79 AFAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLqaFGSVGGILGPLLGGILASSLGFGW-RAVFLI 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505182616 165 GATLSVLLALFTLTLPHIPVANAQRNQSW--TEMLGLNAFALFKNKRMAIFFIFSMMLGAELQITNMFGNTFLHSFdkdp 242
Cdd:cd06174 158 AAALALLAAILLLLVVPDPPESARAKNEEasSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDL---- 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505182616 243 lfsGSFIVEHASVLMSISQISETLFILTIPFFLSRY-GIKNVMLISIVAWMLRFGLFAFGDPTPfgtvLLVLSMIVYGCA 321
Cdd:cd06174 234 ---GGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLiGRKPLLLIGLLLMALGLALLLLAPSLL----LLLLLLLLLGFG 306
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 505182616 322 FDFFNISGSVFVEKEVRPEIRASAQGmFLMMTNGFGCILGGMVSGKVVEHFtvegiTNWQSVWLIFAAYSLVLAVAFV 399
Cdd:cd06174 307 LGGLLPLSFALIAELFPPEIRGTAFG-LLNTFGFLGGAIGPLLAGFLLAAT-----FGLTGAFLVLAVLLLLAAILLL 378
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
11-402 |
7.85e-07 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 50.65 E-value: 7.85e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505182616 11 SFLQFCLWGSWLTTLGSYMfVTLKFDGAAIGAVYSSLGIAAVLMPTLLGIVADKwISAKWVYAICHLVGALTLYLAAQVT 90
Cdd:cd17325 5 LFLDMLGYGIIIPILPLYA-ESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDR-FGRKRLLLLGLLLLAVSTLLFAFAT 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505182616 91 TPGEMFLVILLNSLA---YMPtlglintisyyrlqsAGLDIVTDFPPIRIWGT-IGFILAMWGVSF------SGFELSHM 160
Cdd:cd17325 83 SYWQLLLARFLQGLAsaaVWP---------------AAMALIADIAPPEERGRaMGIFSSAIGLGFligpllGGLLADAL 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505182616 161 QL----YIGATLSVLLALFTLTLPHIPVANAQRNQSWTEMLGLNAFALFKNKRMAIFFIFSMMLGAELQITNMFGNTFLH 236
Cdd:cd17325 148 GYrapfLVCAALALLALVLALLLLPEPRPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAA 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505182616 237 SFdkdplfsGSFIVEHASVLMSISQISETLFILTIPFFLSRYGIKNVMLISIVAWMLRFGLFAFGDptpfGTVLLVLSMI 316
Cdd:cd17325 228 EL-------GGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLAT----SFWLLLLLLA 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505182616 317 VYGCAFDFFNISGSVFVEKEVRPEIRASAQGMFLMMTNgFGCILGGMVSGKVVEHFtvegitNWQSVWLIFAAYSLVLAV 396
Cdd:cd17325 297 LLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFS-LGMVLGPLLGGFLYDAF------GFATPFLAAAALLLLAAV 369
|
....*.
gi 505182616 397 AFVALF 402
Cdd:cd17325 370 LFLLLR 375
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
9-361 |
3.27e-06 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 48.57 E-value: 3.27e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505182616 9 ILSFLQFCLWGSWLTTLGSYMFVTLKFDGAAIGAVYSSLGIAAVLMPTLLGIVADKWiSAKWVYAICHLVGALTLYLAAQ 88
Cdd:pfam07690 3 LAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRF-GRRRVLLIGLLLFALGLLLLLF 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505182616 89 VTTPGEMFLVILLNSLAY--MPTLGLINTISYYRLQSAGLDIVTDFPPIRIWGTIGFILAMWGVSFSGFELShmqLYIGA 166
Cdd:pfam07690 82 ASSLWLLLVLRVLQGLGAgaLFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAA---FLILA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505182616 167 TLSVLLALFTLTLPHIPVANAQRNQSWTEMLGLNAFALFKNKRMAIFFIFSMMLGAELQITNMFGNTFLHSFDKDPLFSG 246
Cdd:pfam07690 159 ILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAG 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505182616 247 sfivehasVLMSISQISETLFILTIPFFLSRYGIKNVMLISIVAWMLRFGLFAFGdPTPFGTVLLVLSMIVYGCAFDFFN 326
Cdd:pfam07690 239 --------LLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLL-SLTLSSLWLLLALLLLGFGFGLVF 309
|
330 340 350
....*....|....*....|....*....|....*
gi 505182616 327 ISGSVFVEKEVRPEIRASAQGMFlMMTNGFGCILG 361
Cdd:pfam07690 310 PALNALVSDLAPKEERGTASGLY-NTAGSLGGALG 343
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
135-404 |
1.33e-05 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 47.20 E-value: 1.33e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505182616 135 IRIWGTIGFILAMWGV-----SFSGFELSHMQL--YIGATLSVLLALFTLTLPHIPVANAQRNQSWTEMLGlnafALFKN 207
Cdd:COG2211 152 RFAFAGLGGLLASVLPpplvaAFGGDAALGYRLtaLIFAVLGLLAFLLTFFGTKERPVPEEEKVSLKESLK----ALLKN 227
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505182616 208 KRMAIFFIFSMMLGAELQITNMFGNTFLHSFDKDPlfsgsfiVEHASVLMSISQISETLFILTIPFFLSRYGIKNVMLIS 287
Cdd:COG2211 228 RPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLS-------AALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIG 300
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505182616 288 IVAWMLRFGLFAFGDPTPFgtVLLVLSMIVYGCAFDFFNISGSVFV-----EKEVRPEIRASAQGM-FLMMTNGFGCILG 361
Cdd:COG2211 301 LLLAALGLLLLFFLGPGNL--WLLLVLAALAGIGLGAILVLPWAMLadvvdYDEWKTGRRREGLYFgIFTFAIKLGQALA 378
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 505182616 362 GMVSGKVVEH--FTVEGITNWQSVWLIFAAYSLV----LAVAFVALFKY 404
Cdd:COG2211 379 GALAGLLLALfgYVAGAAQSPSALTGIRLLFFLLpavlLLLAALLLLFY 427
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
4-357 |
2.58e-04 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 42.65 E-value: 2.58e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505182616 4 KLQLKILSFLQFCLWGSW--LTTLGSYMFVTLKFDGAAIGAVYSSLGIAAVLMPTLLGIVADKWiSAKWVYAICHLVGAL 81
Cdd:COG2814 9 WLALLALALGAFLSGLGIgiVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRF-GRRRVLLLGLLLFAL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505182616 82 TLYLAAQVTTPGEMFLVILLNSLAYMPTLGLINTI--SYYRLQSAGLDIVTDFPPIRIWGTIGFILAMWGVSFSGFelsH 159
Cdd:COG2814 88 GSLLCALAPSLWLLLAARFLQGLGAGALFPAALALiaDLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGW---R 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505182616 160 MQLYIGATLSVLLALFTL-TLPHIPVANAQRnqswtemLGLNAFALFKNKRMAIFFIFSMMLGAELQITNMFGNTFLHSf 238
Cdd:COG2814 165 WVFLVNAVLALLALLLLLrLLPESRPAARAR-------LRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQE- 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505182616 239 dkdplfSGSFIVEHASVLMSISQISETLFILTIPFFLSRYGIKNVMLISIVAWMLRFGLFAFGDptpfGTVLLVLSMIVY 318
Cdd:COG2814 237 ------VLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAG----SLWLLLLALFLL 306
|
330 340 350
....*....|....*....|....*....|....*....
gi 505182616 319 GCAFDFFNISGSVFVEKEVRPEIRASAQGMFLMMTNGFG 357
Cdd:COG2814 307 GFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGG 345
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
12-413 |
8.60e-04 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 41.40 E-value: 8.60e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505182616 12 FLQFCLWGSWlTTLGSYMFVTLKFDGAAIGAVYSSLGIAAVLMPTLLGIVADKWiSAKWVYAICHLVGALTLYLAAQVTT 91
Cdd:COG2223 15 FLAFGVWYLW-SVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRF-GPRRVLLIGLLLLGIGLLLLALAVS 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505182616 92 PGEMFLVILLnslaymptLGLINTISYyrlqSAGLDIVTDFPPIRIWGTIGFILAMWG------------VSFSGFELSH 159
Cdd:COG2223 93 YWLLLLLGLL--------LGIGGGGSF----AVGIALVSKWFPPDRRGLALGLAAGGGnlgaavaaflapLLIAAFGWRN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505182616 160 MQLYIGATLSVLLALFTLTLPHIPVANAQRNQSwtemLGLNAFALFKNKR-MAIFFIFSMMLGAELQITNMFGNTFLHSF 238
Cdd:COG2223 161 AFLILGILLLVVAVLAWLFLRDPPAGAAAAAKA----SLRDQLEALRDPRfWLLSLLYFGTFGSFIGFSSWLPPYLVDQF 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505182616 239 DKDPlfsgsfivEHASVLMSISQISETLFILTIPFFLSRYGIKNVMLISIVAWMLRFGLFAFgdpTPFGTVLLVLSMIVY 318
Cdd:COG2223 237 GLSA--------ATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLAL---ALGSLWLFLVLFLLL 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505182616 319 GCAFDFFNISGSVFVEKEVRPEIRASAQGMFLMMtNGFGCILGGMVSGKVVEHFtvegiTNWQSVWLIFAAysLVLAVAF 398
Cdd:COG2223 306 GLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAA-GGLGGFLGPLLFGALLDAT-----GSYTAAFLVFAV--LALVALV 377
|
410
....*....|....*
gi 505182616 399 VALFKYQHVRQPTAA 413
Cdd:COG2223 378 LTLLLYRRPRRAAAA 392
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
253-402 |
1.26e-03 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 40.62 E-value: 1.26e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505182616 253 ASVLMSISQISETLFILTIPFFLSRYGIKNVMLISIVAWMLRFGLFAFGDptpfGTVLLVLSMIVYGCAFDFFNISGSVF 332
Cdd:COG2271 47 LGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFAT----SFWQLLLLRFLLGLGEAGFFPAALKL 122
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505182616 333 VEKEVRPEIRASAQGMFLMMTNgFGCILGGMVSGKVVEHFtvegitNWQSVWLIFAAYSLVLAVAFVALF 402
Cdd:COG2271 123 IAEWFPPKERGRALGIFNAGGP-LGGALAPPLLGWLLAAF------GWRAAFLILGLPGLLLALLRFWLL 185
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
200-416 |
1.83e-03 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 39.96 E-value: 1.83e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505182616 200 NAFALFKNKRMAIFFIFSMMLGAELQITNMFGNTFLHSFDKDPLfsgsfiveHASVLMSISQISETLFILTIPFFLSRYG 279
Cdd:COG2814 2 PATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPA--------QAGLVVTAYLLGAALGAPLAGRLADRFG 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505182616 280 IKNVMLISIVAWMLRFGLFAFGDptpfGTVLLVLSMIVYGCAFDFFNISGSVFVEKEVRPEIRASAQGMFlMMTNGFGCI 359
Cdd:COG2814 74 RRRVLLLGLLLFALGSLLCALAP----SLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLL-GAGLGLGPA 148
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 505182616 360 LGGMVSGKVVEHFtvegitNWQSVWLIFAAYSLVLAVAFVALFKYQHVRQPTAARQN 416
Cdd:COG2814 149 LGPLLGGLLADLF------GWRWVFLVNAVLALLALLLLLRLLPESRPAARARLRGS 199
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
244-402 |
2.42e-03 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 39.83 E-value: 2.42e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505182616 244 FSGSFIVEHAS----------VLMSISQISETLFILTIPFFLSRYGIKNVMLISIVAWMLRFGLFAFGDPTPFgtvlLVL 313
Cdd:cd17370 217 FSFAFLILRAQelglsaalipLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWL----LLL 292
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505182616 314 SMIVYGCAFDFFNISGSVFVEKEVRPEIRASAQGMFlMMTNGFGCILGGMVSGKVVEHFtvegitnwqSVWLIFAAYSLV 393
Cdd:cd17370 293 GFILWGLYMGAQESIERAAVADLVPAELRGTAYGLF-NTVVGIGWLLASLIAGYLWDLI---------SPSAAFLFSAVL 362
|
....*....
gi 505182616 394 LAVAFVALF 402
Cdd:cd17370 363 ALIALLLLL 371
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
38-375 |
4.92e-03 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 38.69 E-value: 4.92e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505182616 38 AAIGAVYSSLGIAAVLMPTLLGIVADKWiSAKWVYAICHLVGALTLYLAAQVTTPGEMFLVILLNSL---AYMPtlglin 114
Cdd:cd17478 31 AQAGLLVSVFSITSSLLQPLFGYLADRK-PRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGIgsaAFHP------ 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505182616 115 tisyyrlqsAGLDIVTDFPPIR---------IWGTIGF----ILAMWGVSFSGFELSHMQLYIGATLSVLLALFTLTLPH 181
Cdd:cd17478 104 ---------EGARLASQAAGGRrglamsifsVGGNLGFalgpLIAAALVALFGGLGLLILLIIPGLAVALLLLRLRPLKK 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505182616 182 IPVANAQRNQSWTEMLGLNAFALFKnkRMAIFFIFSMMLGAelqitnmfGNTFLHSFDKDPLFSGSFIVEHASVLMSISQ 261
Cdd:cd17478 175 PEAKKAAAKSSARSTLKGVWRALLL--LLIIVFLRSWVLSS--------LTTFLPFYLVQRGYSLVFAGLLLSLFLFAGA 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505182616 262 ISetlfILTIPFFLSRYGIKNVMLISIVAWMLRFGLFAFgdptpFGTVLLVLSMIVYGcAFDFFNISGSVFVEKEVRPEI 341
Cdd:cd17478 245 IG----TLIGGPLSDRFGRRRVIIASLLLAAPFLLLFLL-----TPGIWSYILLVLAG-FLLFASFPVTVVLAQELLPGN 314
|
330 340 350
....*....|....*....|....*....|....
gi 505182616 342 RASAQGMFLMMTNGFGCIlGGMVSGKVVEHFTVE 375
Cdd:cd17478 315 VGLASGLMMGLSFGLGGI-GAPVLGALADAFGLE 347
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
253-399 |
8.23e-03 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 38.17 E-value: 8.23e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505182616 253 ASVLMSISQISETLFILTIPFFLSRYGIKNVMLISIVAWMLRFGLFAFGDPTPfgtvLLVLSMIVYGCAFDFFNISGSVF 332
Cdd:pfam07690 34 IGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLW----LLLVLRVLQGLGAGALFPAALAL 109
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 505182616 333 VEKEVRPEIRASAQGmFLMMTNGFGCILGGMVSGKVVEHFtvegitNWQSVWLIFAAYSLVLAVAFV 399
Cdd:pfam07690 110 IADWFPPEERGRALG-LVSAGFGLGAALGPLLGGLLASLF------GWRAAFLILAILSLLAAVLLL 169
|
|
| |
