NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|505183130|ref|WP_015370232|]
View 

MULTISPECIES: site-specific DNA-methyltransferase [Klebsiella]

Protein Classification

DNA-methyltransferase( domain architecture ID 10002921)

DNA methyltransferase catalyzes specific methylation on cytosine or adenine on both strands and protects the DNA from cleavage by endonuclease; belongs to the class I SAM-dependent methyltransferase superfamily

CATH:  2.20.25.110
SCOP:  3000118

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
YhdJ COG0863
DNA modification methylase [Replication, recombination and repair];
12-349 1.71e-54

DNA modification methylase [Replication, recombination and repair];


:

Pssm-ID: 440623  Cd Length: 236  Bit Score: 178.96  E-value: 1.71e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505183130  12 LINADCLQYLPSLPDNSIDLIVTDPPYFKVKPNGW----DNQWKGDEDYLRWLDSCLAQFWRVLKPAGSMYLFCGHRLAA 87
Cdd:COG0863    2 LICGDCLEVLKELPDESVDLIVTDPPYNLGKKYGLgrreIGNELSFEEYLEFLREWLAECYRVLKPGGSLYVNIGDRYIS 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505183130  88 DIELLVRE-RFNLLNHIIWAKPSGRWNGCNkeslRAYFPATERIIFadhyqgpYRpKDDGYaakcnelkqhvmtplisyf 166
Cdd:COG0863   82 RLIAALRDaGFKLRNEIIWRKPNGVPGPSK----RRFRNSHEYILW-------FT-KGKKY------------------- 130

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505183130 167 rdareslgvtsaqiaeatgkknmishwfglsqwqlpneddylklqaLFQKIAMDKHSRNElgkphhqlvatwqslnrkys 246
Cdd:COG0863  131 ----------------------------------------------TFNVDAVKSIEDGR-------------------- 144

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505183130 247 elqqeyyrlrrpfsvsvtvPYTDVWTHKPVQF-YPGKHPCEKPADMLQQIISASSRPGDVVADFFAGSGSTLKQAALLGR 325
Cdd:COG0863  145 -------------------NPSDVWDIPGVTPkERKGHPTQKPVELLERLILASSNPGDIVLDPFAGSGTTLVAAERLGR 205

                        330       340       350
                 ....*....|....*....|....*....|.
gi 505183130 326 SGIGVELE-------TERFEQTVSEIRNLLE 349
Cdd:COG0863  206 RFIGIEIDpeyvevaRRRLEEATGLEFEELA 236
 
Name Accession Description Interval E-value
YhdJ COG0863
DNA modification methylase [Replication, recombination and repair];
12-349 1.71e-54

DNA modification methylase [Replication, recombination and repair];


Pssm-ID: 440623  Cd Length: 236  Bit Score: 178.96  E-value: 1.71e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505183130  12 LINADCLQYLPSLPDNSIDLIVTDPPYFKVKPNGW----DNQWKGDEDYLRWLDSCLAQFWRVLKPAGSMYLFCGHRLAA 87
Cdd:COG0863    2 LICGDCLEVLKELPDESVDLIVTDPPYNLGKKYGLgrreIGNELSFEEYLEFLREWLAECYRVLKPGGSLYVNIGDRYIS 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505183130  88 DIELLVRE-RFNLLNHIIWAKPSGRWNGCNkeslRAYFPATERIIFadhyqgpYRpKDDGYaakcnelkqhvmtplisyf 166
Cdd:COG0863   82 RLIAALRDaGFKLRNEIIWRKPNGVPGPSK----RRFRNSHEYILW-------FT-KGKKY------------------- 130

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505183130 167 rdareslgvtsaqiaeatgkknmishwfglsqwqlpneddylklqaLFQKIAMDKHSRNElgkphhqlvatwqslnrkys 246
Cdd:COG0863  131 ----------------------------------------------TFNVDAVKSIEDGR-------------------- 144

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505183130 247 elqqeyyrlrrpfsvsvtvPYTDVWTHKPVQF-YPGKHPCEKPADMLQQIISASSRPGDVVADFFAGSGSTLKQAALLGR 325
Cdd:COG0863  145 -------------------NPSDVWDIPGVTPkERKGHPTQKPVELLERLILASSNPGDIVLDPFAGSGTTLVAAERLGR 205

                        330       340       350
                 ....*....|....*....|....*....|.
gi 505183130 326 SGIGVELE-------TERFEQTVSEIRNLLE 349
Cdd:COG0863  206 RFIGIEIDpeyvevaRRRLEEATGLEFEELA 236
N6_N4_Mtase pfam01555
DNA methylase; Members of this family are DNA methylases. The family contains both N-4 ...
 29-341 6.73e-36

DNA methylase; Members of this family are DNA methylases. The family contains both N-4 cytosine-specific DNA methylases and N-6 Adenine-specific DNA methylases.


Pssm-ID: 396230 [Multi-domain]  Cd Length: 221  Bit Score: 130.21  E-value: 6.73e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505183130   29 IDLIVTDPPYFKVKPNGWDNQWKGDEDYLRWLDSCLAQFWRVLKPAGSMYLFCGHRLAADIELLVRE---RFNLLNHIIW 105
Cdd:pfam01555   1 VDLIVTDPPYNLGKDYGQWDDKDSIEEYLEWLEEWLKEVRRVLKPGGSIFINIGDSNIKSLKALALEilgIFKLLNDIIW 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505183130  106 AKPSGRWNGcNKESLRayfPATERIIfadhyqgpyrpkddgyaakcnelkqhvmtplisyfrdareslgvtsaqiaeatg 185
Cdd:pfam01555  81 RKPNGMPNS-NGERFT---PAHEYIL------------------------------------------------------ 102

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505183130  186 kknmishWFGLSQWQLPNEDDYLKLQalfqkiamdkhsrnelgkphhqlvatwqslnrkYSELQQEYYRLRRPFSVsvtv 265
Cdd:pfam01555 103 -------WFSKTKKYKTFNYDAIKVP---------------------------------YDEKDKLKKRGSEPNGK---- 138

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505183130  266 PYTDVWTHKPVQFYP------GKHPCEKPADMLQQIISASSRPGDVVADFFAGSGSTLKQAALLGRSGIGVELETERFEQ 339
Cdd:pfam01555 139 PIGDVWDFSRVQPSEkesggnGKHPTQKPEALLERLILASTNPGDIVLDPFAGSGTTGAAAKELGRNFIGIEIEEEYVEI 218


                  ..
gi 505183130  340 TV 341
Cdd:pfam01555 219 AK 220
PRK11524 PRK11524
adenine-specific DNA-methyltransferase;
12-335 3.49e-22

adenine-specific DNA-methyltransferase;


Pssm-ID: 183177 [Multi-domain]  Cd Length: 284  Bit Score: 94.79  E-value: 3.49e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505183130  12 LINADCLQYLPSLPDNSIDLIVTDPPYFKVKP-NGWDNQWKgDEDYLRWLDSCLAQFWRVLKPAGSMYLFCGHRLAADIE 90
Cdd:PRK11524  11 IIHGDALTELKKIPSESVDLIFADPPYNIGKNfDGLIEAWK-EDLFIDWLYEWIDECHRVLKKQGTMYIMNSTENMPFID 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505183130  91 LLVRERFNLLNHIIWAKPSGRWNGCNKeslrayfpateriiFADHYQgpyrpkddgyaakcnelkqhvmtPLISYFRDAR 170
Cdd:PRK11524  90 LYCRKLFTIKSRIVWSYDSSGVQAKKY--------------FGSMYE-----------------------PILMMVKDAK 132

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505183130 171 ESLGVTSAQIAEA-TG-KKNMIshwfglsqwqlpnedDYlklqalfqkiamdkhsRNELGKPHHqlvatwqslnrkysel 248
Cdd:PRK11524 133 NYTFNGDAILVEAkTGaKRALI---------------DY----------------RKNPPQPYN---------------- 165

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505183130 249 qqeyyrlrrpfsvSVTVPyTDVWTHKPVQF----YPgKHPCEKPADMLQQIISASSRPGDVVADFFAGSGSTLKQAALLG 324
Cdd:PRK11524 166 -------------TQKVP-GNVWDFPRVRYlmdeYE-NHPTQKPEALLKRIILASSNPGDIVLDPFAGSFTTGAVAKASG 230

                        330
                 ....*....|.
gi 505183130 325 RSGIGVELETE 335
Cdd:PRK11524 231 RKFIGIEINSE 241
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 6-79 5.63e-03

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 36.25  E-value: 5.63e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 505183130   6 KISSIELINADCLQyLPSLPDNSIDLIVTDPPYFKVKpngwdnqwkgdEDYLRWLDsclaQFWRVLKPAGSMYL 79
Cdd:cd02440   45 LADNVEVLKGDAEE-LPPEADESFDVIISDPPLHHLV-----------EDLARFLE----EARRLLKPGGVLVL 102
 
Name Accession Description Interval E-value
YhdJ COG0863
DNA modification methylase [Replication, recombination and repair];
12-349 1.71e-54

DNA modification methylase [Replication, recombination and repair];


Pssm-ID: 440623  Cd Length: 236  Bit Score: 178.96  E-value: 1.71e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505183130  12 LINADCLQYLPSLPDNSIDLIVTDPPYFKVKPNGW----DNQWKGDEDYLRWLDSCLAQFWRVLKPAGSMYLFCGHRLAA 87
Cdd:COG0863    2 LICGDCLEVLKELPDESVDLIVTDPPYNLGKKYGLgrreIGNELSFEEYLEFLREWLAECYRVLKPGGSLYVNIGDRYIS 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505183130  88 DIELLVRE-RFNLLNHIIWAKPSGRWNGCNkeslRAYFPATERIIFadhyqgpYRpKDDGYaakcnelkqhvmtplisyf 166
Cdd:COG0863   82 RLIAALRDaGFKLRNEIIWRKPNGVPGPSK----RRFRNSHEYILW-------FT-KGKKY------------------- 130

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505183130 167 rdareslgvtsaqiaeatgkknmishwfglsqwqlpneddylklqaLFQKIAMDKHSRNElgkphhqlvatwqslnrkys 246
Cdd:COG0863  131 ----------------------------------------------TFNVDAVKSIEDGR-------------------- 144

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505183130 247 elqqeyyrlrrpfsvsvtvPYTDVWTHKPVQF-YPGKHPCEKPADMLQQIISASSRPGDVVADFFAGSGSTLKQAALLGR 325
Cdd:COG0863  145 -------------------NPSDVWDIPGVTPkERKGHPTQKPVELLERLILASSNPGDIVLDPFAGSGTTLVAAERLGR 205

                        330       340       350
                 ....*....|....*....|....*....|.
gi 505183130 326 SGIGVELE-------TERFEQTVSEIRNLLE 349
Cdd:COG0863  206 RFIGIEIDpeyvevaRRRLEEATGLEFEELA 236
N6_N4_Mtase pfam01555
DNA methylase; Members of this family are DNA methylases. The family contains both N-4 ...
 29-341 6.73e-36

DNA methylase; Members of this family are DNA methylases. The family contains both N-4 cytosine-specific DNA methylases and N-6 Adenine-specific DNA methylases.


Pssm-ID: 396230 [Multi-domain]  Cd Length: 221  Bit Score: 130.21  E-value: 6.73e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505183130   29 IDLIVTDPPYFKVKPNGWDNQWKGDEDYLRWLDSCLAQFWRVLKPAGSMYLFCGHRLAADIELLVRE---RFNLLNHIIW 105
Cdd:pfam01555   1 VDLIVTDPPYNLGKDYGQWDDKDSIEEYLEWLEEWLKEVRRVLKPGGSIFINIGDSNIKSLKALALEilgIFKLLNDIIW 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505183130  106 AKPSGRWNGcNKESLRayfPATERIIfadhyqgpyrpkddgyaakcnelkqhvmtplisyfrdareslgvtsaqiaeatg 185
Cdd:pfam01555  81 RKPNGMPNS-NGERFT---PAHEYIL------------------------------------------------------ 102

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505183130  186 kknmishWFGLSQWQLPNEDDYLKLQalfqkiamdkhsrnelgkphhqlvatwqslnrkYSELQQEYYRLRRPFSVsvtv 265
Cdd:pfam01555 103 -------WFSKTKKYKTFNYDAIKVP---------------------------------YDEKDKLKKRGSEPNGK---- 138

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505183130  266 PYTDVWTHKPVQFYP------GKHPCEKPADMLQQIISASSRPGDVVADFFAGSGSTLKQAALLGRSGIGVELETERFEQ 339
Cdd:pfam01555 139 PIGDVWDFSRVQPSEkesggnGKHPTQKPEALLERLILASTNPGDIVLDPFAGSGTTGAAAKELGRNFIGIEIEEEYVEI 218


                  ..
gi 505183130  340 TV 341
Cdd:pfam01555 219 AK 220
PRK11524 PRK11524
adenine-specific DNA-methyltransferase;
12-335 3.49e-22

adenine-specific DNA-methyltransferase;


Pssm-ID: 183177 [Multi-domain]  Cd Length: 284  Bit Score: 94.79  E-value: 3.49e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505183130  12 LINADCLQYLPSLPDNSIDLIVTDPPYFKVKP-NGWDNQWKgDEDYLRWLDSCLAQFWRVLKPAGSMYLFCGHRLAADIE 90
Cdd:PRK11524  11 IIHGDALTELKKIPSESVDLIFADPPYNIGKNfDGLIEAWK-EDLFIDWLYEWIDECHRVLKKQGTMYIMNSTENMPFID 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505183130  91 LLVRERFNLLNHIIWAKPSGRWNGCNKeslrayfpateriiFADHYQgpyrpkddgyaakcnelkqhvmtPLISYFRDAR 170
Cdd:PRK11524  90 LYCRKLFTIKSRIVWSYDSSGVQAKKY--------------FGSMYE-----------------------PILMMVKDAK 132

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505183130 171 ESLGVTSAQIAEA-TG-KKNMIshwfglsqwqlpnedDYlklqalfqkiamdkhsRNELGKPHHqlvatwqslnrkysel 248
Cdd:PRK11524 133 NYTFNGDAILVEAkTGaKRALI---------------DY----------------RKNPPQPYN---------------- 165

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505183130 249 qqeyyrlrrpfsvSVTVPyTDVWTHKPVQF----YPgKHPCEKPADMLQQIISASSRPGDVVADFFAGSGSTLKQAALLG 324
Cdd:PRK11524 166 -------------TQKVP-GNVWDFPRVRYlmdeYE-NHPTQKPEALLKRIILASSNPGDIVLDPFAGSFTTGAVAKASG 230

                        330
                 ....*....|.
gi 505183130 325 RSGIGVELETE 335
Cdd:PRK11524 231 RKFIGIEINSE 241
Mod COG2189
Adenine specific DNA methylase Mod [Replication, recombination and repair];
12-333 1.32e-10

Adenine specific DNA methylase Mod [Replication, recombination and repair];


Pssm-ID: 441792 [Multi-domain]  Cd Length: 491  Bit Score: 62.48  E-value: 1.32e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505183130  12 LINADCLQYLPSL---PDNSIDLIVTDPPY-----FKVKPNGWDNQWKGDE--DYLRWLDSCLAQFWRVLKPAGSMYLFC 81
Cdd:COG2189   39 LIEGDNLEALKLLqesYAGKVKCIYIDPPYntgndFFAYNDNFETESNGRFhsSWLSMMYPRLKLARELLSEDGVIFVSI 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505183130  82 GHRLAADIELLVRERF---NLLNHIIWAKPSGRwngcnkESLRAYF-PATERIIF----ADHYQGPYRPKDDGYAAKCNE 153
Cdd:COG2189  119 DDNEVHYLKLLLDEIFgeeNFVATIIWKKKSSG------KNDAKFFsRTHEYILVyaknKSYLKFNGLPRTEEQLKRYKN 192

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505183130 154 LKQHVMTPlisYFRDARESLGVTSAQIAEATGKKNMISHWFGlSQWQLPneddylklQALFQKiaMDKHSRNELGKPHhq 233
Cdd:COG2189  193 PDNDPRGR---WRSVPLTAPGGRPNLFYPIEHPSTGKEVYPG-RGWRWS--------KETMEE--LIADGRIYFGKDG-- 256

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505183130 234 lvaTWQSLNRKYselQQEYYRLRRPFSVSVTVPYTDVWTHKPVQFYPGKH-PCEKPADMLQQIISASSRPGDVVADFFAG 312
Cdd:COG2189  257 ---NGVPRRKRY---LDEVKKGVVPTTIWDDIGTNQNGTKELKELFGGKVfDTPKPEKLLKRIIEIATNPGDLVLDFFAG 330

                        330       340
                 ....*....|....*....|....*...
gi 505183130 313 SGSTLkQAAL-LGRSG------IGVELE 333
Cdd:COG2189  331 SGTTA-HAVMkLNAEDggnrrfILVQLG 357
PRK13699 PRK13699
putative methylase; Provisional
 283-332 3.38e-10

putative methylase; Provisional


Pssm-ID: 184255  Cd Length: 227  Bit Score: 59.46  E-value: 3.38e-10
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 505183130 283 HPCEKPADMLQQIISASSRPGDVVADFFAGSGSTLKQAALLGRSGIGVEL 332
Cdd:PRK13699 144 HPTEKPVTSLQPLIESFTHPNAIVLDPFAGSGSTCVAALQSGRRYIGIEL 193
COG2521 COG2521
Predicted archaeal methyltransferase [General function prediction only];
10-82 3.92e-05

Predicted archaeal methyltransferase [General function prediction only];


Pssm-ID: 442011 [Multi-domain]  Cd Length: 285  Bit Score: 44.90  E-value: 3.92e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 505183130  10 IELINADCLQYLPSLPDNSIDLIVTDPPYFKVkpngwdnqwKGD---EDYLRwldsclaQFWRVLKPAGSMYLFCG 82
Cdd:COG2521  185 IKIILGDASEVIKTFPDESFDAIIHDPPRFSL---------AGElysLEFYR-------ELYRVLKPGGRLFHYTG 244
Trm11 COG1041
tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 ...
 298-351 4.54e-05

tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 N-methylase Trm11 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440663 [Multi-domain]  Cd Length: 172  Bit Score: 43.40  E-value: 4.54e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 505183130 298 ASSRPGDVVADFFAGSGSTLKQAALLGRSGIGVELETERFEQTvseIRNlLEHL 351
Cdd:COG1041   22 AGAKEGDTVLDPFCGTGTILIEAGLLGRRVIGSDIDPKMVEGA---REN-LEHY 71
TrmN6 COG4123
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ...
 10-79 4.20e-04

tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443299 [Multi-domain]  Cd Length: 238  Bit Score: 41.28  E-value: 4.20e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 505183130  10 IELINADCLQYLPSLPDNSIDLIVTDPPYFKV---KPNgwDNQWK------GDEDYLRWLDSClaqfWRVLKPAGSMYL 79
Cdd:COG4123   90 ITVIHGDLKEFAAELPPGSFDLVVSNPPYFKAgsgRKS--PDEARaiarheDALTLEDLIRAA----ARLLKPGGRFAL 162
Trm11 COG1041
tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 ...
 6-75 4.31e-04

tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 N-methylase Trm11 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440663 [Multi-domain]  Cd Length: 172  Bit Score: 40.70  E-value: 4.31e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 505183130   6 KISSIELINADClQYLPsLPDNSIDLIVTDPPY---FKVKPngwdnqwkgdEDYLRWLDSCLAQFWRVLKPAG 75
Cdd:COG1041   72 GYEDADVIRGDA-RDLP-LADESVDAIVTDPPYgrsSKISG----------EELLELYEKALEEAARVLKPGG 132
PRK14968 PRK14968
putative methyltransferase; Provisional
 3-79 7.20e-04

putative methyltransferase; Provisional


Pssm-ID: 237872 [Multi-domain]  Cd Length: 188  Bit Score: 40.27  E-value: 7.20e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505183130   3 NTVKISSIELINADCLQylpSLPDNSIDLIVTDPPYFKV----KPNGWDN-QWKGDEDYLRWLDSCLAQFWRVLKPAGSM 77
Cdd:PRK14968  68 NNIRNNGVEVIRSDLFE---PFRGDKFDVILFNPPYLPTeeeeEWDDWLNyALSGGKDGREVIDRFLDEVGRYLKPGGRI 144


                 ..
gi 505183130  78 YL 79
Cdd:PRK14968 145 LL 146
TrmR COG4122
tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; ...
 10-48 3.57e-03

tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; tRNA 5-hydroxyU34 O-methylase TrmR/YrrM is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443298  Cd Length: 173  Bit Score: 37.86  E-value: 3.57e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 505183130  10 IELINADCLQYLPSLPDNSIDLIVTD------PPYF-----KVKPNG---WDN 48
Cdd:COG4122   70 IRLILGDALEVLPRLADGPFDLVFIDadksnyPDYLelalpLLRPGGlivADN 122
COG1743 COG1743
Adenine-specific DNA methylase, contains a Zn-ribbon domain [Replication, recombination and ...
 8-39 3.61e-03

Adenine-specific DNA methylase, contains a Zn-ribbon domain [Replication, recombination and repair];


Pssm-ID: 441349 [Multi-domain]  Cd Length: 871  Bit Score: 39.15  E-value: 3.61e-03
                         10        20        30
                 ....*....|....*....|....*....|..
gi 505183130   8 SSIELINADClQYLPsLPDNSIDLIVTDPPYF 39
Cdd:COG1743  477 GNGTVLQGDA-TDLP-LPDGSVDAVVTDPPYY 506
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 6-79 5.63e-03

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 36.25  E-value: 5.63e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 505183130   6 KISSIELINADCLQyLPSLPDNSIDLIVTDPPYFKVKpngwdnqwkgdEDYLRWLDsclaQFWRVLKPAGSMYL 79
Cdd:cd02440   45 LADNVEVLKGDAEE-LPPEADESFDVIISDPPLHHLV-----------EDLARFLE----EARRLLKPGGVLVL 102
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH