|
Name |
Accession |
Description |
Interval |
E-value |
| MetC |
COG0626 |
Cystathionine beta-lyase/cystathionine gamma-synthase [Amino acid transport and metabolism]; ... |
3-380 |
0e+00 |
|
Cystathionine beta-lyase/cystathionine gamma-synthase [Amino acid transport and metabolism]; Cystathionine beta-lyase/cystathionine gamma-synthase is part of the Pathway/BioSystem: Methionine biosynthesis
Pssm-ID: 440391 [Multi-domain] Cd Length: 389 Bit Score: 609.74 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 3 KFDTLTVHAGYTPD-ATGAVMPAIYATSTYAQPAP--------GEHTGYEYSRSANPTRTALESAIAELEGGSRGYAFAS 73
Cdd:COG0626 2 GPATRAVHAGRDPDpQTGAVSPPIYLTSTFVFPSAealaarfaGEEGGYIYSRYGNPTRRALEEALAALEGGEAALAFAS 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 74 GLAACSTV-LELLDKDSHLIAVDDLYGGTYRLLEKVRSRtAGLRVTYVAPADLAGLEQAIEPDTKMIWVETPTNPLLKLA 152
Cdd:COG0626 82 GMAAISAVlLALLKAGDHVVASDDLYGGTRRLLDKVLAR-FGIEVTFVDPTDLAAVEAAIRPNTKLVFLETPSNPTLEVV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 153 DLSAIAAIAKKHQLISVADNTFASPYLQRPLDLGFDVVVHSATKYLNGHSDVVAGvAAVGDNPALAEQLGFLQNAVGGIL 232
Cdd:COG0626 161 DIAAIAAIAHAAGALLVVDNTFATPLLQRPLELGADIVVHSATKYLGGHSDVLGG-AVVGRDEELAERLRFLQNALGAVL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 233 DPFSSFLTLRGVRTLALRMQRHSDSALRIAQWLESQPQVENVYYPGLPSHPQHELAARQMTRFGGMISVRLKGDDAYARR 312
Cdd:COG0626 240 SPFDAWLLLRGLKTLALRMERHCENALAVAEWLEAHPAVARVYYPGLPSHPGHELAKRQMSGFGGMLSFELKGGREAARR 319
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 505190166 313 VIQRSRLFTLAESLGGVESLISQPFSMTHASIPLEQRLATGITPQLVRLSVGIEDVEDLIADLQQALA 380
Cdd:COG0626 320 FLDALKLFTLAVSLGGVESLITHPATMTHRSLPPEERAALGITDGLVRLSVGLEDVDDLIADLEQALA 387
|
|
| Cys_Met_Meta_PP |
pfam01053 |
Cys/Met metabolism PLP-dependent enzyme; This family includes enzymes involved in cysteine and ... |
5-380 |
0e+00 |
|
Cys/Met metabolism PLP-dependent enzyme; This family includes enzymes involved in cysteine and methionine metabolism. The following are members: Cystathionine gamma-lyase, Cystathionine gamma-synthase, Cystathionine beta-lyase, Methionine gamma-lyase, OAH/OAS sulfhydrylase, O-succinylhomoserine sulfhydrylase All of these members participate is slightly different reactions. All these enzymes use PLP (pyridoxal-5'-phosphate) as a cofactor.
Pssm-ID: 395837 [Multi-domain] Cd Length: 376 Bit Score: 559.16 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 5 DTLTVHAGYTPD-ATGAVMPAIYATSTYAQPAPGEHTGYEYSRSANPTRTALESAIAELEGGSRGYAFASGLAA-CSTVL 82
Cdd:pfam01053 1 DTLAVHAGQRPDpQTGAVSVPIYLTSTYVFDFAGEEGGYDYSRSGNPTRDVLEERIAALEGGAAALAFSSGMAAiTAAIL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 83 ELLDKDSHLIAVDDLYGGTYRLLEKVRSRTaGLRVTYVAPADLAGLEQAIEPDTKMIWVETPTNPLLKLADLSAIAAIAK 162
Cdd:pfam01053 81 ALLKAGDHIVATDDLYGGTYRLFNKVLPRF-GIEVTFVDTSDPEDLEAAIKPNTKAVYLETPTNPLLKVVDIEAIAKLAK 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 163 KHQLISVADNTFASPYLQRPLDLGFDVVVHSATKYLNGHSDVVAGVAAVGDnPALAEQLGFLQNAVGGILDPFSSFLTLR 242
Cdd:pfam01053 160 KHGILVVVDNTFASPYLQRPLDLGADIVVHSATKYIGGHSDVVGGVIVVNG-EELGKELYFLQNATGAVLSPFDAWLLLR 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 243 GVRTLALRMQRHSDSALRIAQWLESQPQVENVYYPGLPSHPQHELAARQMTRFGGMISVRLKGDDAYARRVIQRSRLFTL 322
Cdd:pfam01053 239 GLKTLGLRMEQHQENAQKVAEFLESHPKVEKVYYPGLPSHPGHELAKRQMKGFGGMLSFELKGGLEAAKKFLDNLKLFSL 318
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 505190166 323 AESLGGVESLISQPFSMTHASIPLEQRLATGITPQLVRLSVGIEDVEDLIADLQQALA 380
Cdd:pfam01053 319 AVSLGGVESLISHPATMTHASIPPEEREAAGITDDLIRLSVGIEDVDDLIADLKQALE 376
|
|
| PRK07811 |
PRK07811 |
cystathionine gamma-synthase; Provisional |
4-380 |
0e+00 |
|
cystathionine gamma-synthase; Provisional
Pssm-ID: 236104 [Multi-domain] Cd Length: 388 Bit Score: 525.75 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 4 FDTLTVHAGYTPD-ATGAVMPAIYATSTYAQPAPGE-HTGYEYSRSANPTRTALESAIAELEGGSRGYAFASGLAACSTV 81
Cdd:PRK07811 13 FATRAIHAGYEPDpATGAVNPPIYASSTFAQDGVGGlRGGYEYARTGNPTRTALEEQLAALEGGAYGRAFSSGMAATDCL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 82 LE-LLDKDSHLIAVDDLYGGTYRLLEKVRSRTaGLRVTYVAPADLAGLEQAIEPDTKMIWVETPTNPLLKLADLSAIAAI 160
Cdd:PRK07811 93 LRaVLRPGDHIVIPNDAYGGTFRLIDKVFTRW-GVEYTPVDLSDLDAVRAAITPRTKLIWVETPTNPLLSITDIAALAEL 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 161 AKKHQLISVADNTFASPYLQRPLDLGFDVVVHSATKYLNGHSDVVAGVAAVGDnPALAEQLGFLQNAVGGILDPFSSFLT 240
Cdd:PRK07811 172 AHDAGAKVVVDNTFASPYLQQPLALGADVVVHSTTKYIGGHSDVVGGALVTND-EELDEAFAFLQNGAGAVPGPFDAYLT 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 241 LRGVRTLALRMQRHSDSALRIAQWLESQPQVENVYYPGLPSHPQHELAARQMTRFGGMISVRLKGDDAYARRVIQRSRLF 320
Cdd:PRK07811 251 LRGLKTLAVRMDRHSENAEAVAEFLAGHPEVSTVLYPGLPSHPGHEVAARQMRGFGGMVSVRLAGGEEAARDFCARTKVF 330
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 505190166 321 TLAESLGGVESLISQPFSMTHASI---PLEqrlatgITPQLVRLSVGIEDVEDLIADLQQALA 380
Cdd:PRK07811 331 TLAESLGGVESLIEHPSAMTHASTagsQLE------VPDDLVRLSVGIEDVADLLADLEQALG 387
|
|
| CGS_like |
cd00614 |
CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed ... |
19-380 |
0e+00 |
|
CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of antimicrobials and herbicides. This subgroup also includes cystathionine gamma-lyases (CGL), O-acetylhomoserine sulfhydrylases and O-acetylhomoserine thiol lyases. CGL's are very similar to CGS's. Members of this group are widely distributed among all three forms of life.
Pssm-ID: 99738 [Multi-domain] Cd Length: 369 Bit Score: 517.53 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 19 GAVMPAIYATSTYAQPAPGE--------HTGYEYSRSANPTRTALESAIAELEGGSRGYAFASGLAACSTVLE-LLDKDS 89
Cdd:cd00614 1 GAVAPPIYQTSTFVFPSPAEaadlfalrEGGYIYSRIGNPTVDALEKKLAALEGGEAALAFSSGMAAISTVLLaLLKAGD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 90 HLIAVDDLYGGTYRLLEKVRSRTaGLRVTYVAPADLAGLEQAIEPDTKMIWVETPTNPLLKLADLSAIAAIAKKHQLISV 169
Cdd:cd00614 81 HVVASDDLYGGTYRLFERLLPKL-GIEVTFVDPDDPEALEAAIKPETKLVYVESPTNPTLKVVDIEAIAELAHEHGALLV 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 170 ADNTFASPYLQRPLDLGFDVVVHSATKYLNGHSDVVAGVAaVGDNPALAEQLGFLQNAVGGILDPFSSFLTLRGVRTLAL 249
Cdd:cd00614 160 VDNTFATPYLQRPLELGADIVVHSATKYIGGHSDVIAGVV-VGSGEALIQRLRFLRLALGTILSPFDAWLLLRGLKTLPL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 250 RMQRHSDSALRIAQWLESQPQVENVYYPGLPSHPQHELAARQMTRFGGMISVRLKGDDAYARRVIQRSRLFTLAESLGGV 329
Cdd:cd00614 239 RMERHSENALKVAEFLEKHPKVERVYYPGLPSHPQHELAKKQMSGYGGVFSFELKGGLEAAKKFLNALKLFSLAVSLGGV 318
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 505190166 330 ESLISQPFSMTHASIPLEQRLATGITPQLVRLSVGIEDVEDLIADLQQALA 380
Cdd:cd00614 319 ESLVEHPASMTHSQLPPEERAAAGITPGLVRLSVGIEDVEDLIADLEQALK 369
|
|
| PRK07671 |
PRK07671 |
bifunctional cystathionine gamma-lyase/homocysteine desulfhydrase; |
6-380 |
4.20e-180 |
|
bifunctional cystathionine gamma-lyase/homocysteine desulfhydrase;
Pssm-ID: 181076 [Multi-domain] Cd Length: 377 Bit Score: 505.03 E-value: 4.20e-180
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 6 TLTVHAGYTPD-ATGAVMPAIYATSTYAQPAPGEHTGYEYSRSANPTRTALESAIAELEGGSRGYAFASGLAACSTVLEL 84
Cdd:PRK07671 5 TKLIHGGIIGDpSTGAVSVPIYQVSTYKQEAVGKHQGYEYSRTGNPTRAALEELIAVLEGGHAGFAFGSGMAAITAVMML 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 85 LDKDSHLIAVDDLYGGTYRLLEKVRSRTaGLRVTYVAPADLAGLEQAIEPDTKMIWVETPTNPLLKLADLSAIAAIAKKH 164
Cdd:PRK07671 85 FSSGDHVILTDDVYGGTYRVMTKVLNRF-GIEHTFVDTSNLEEVEEAIRPNTKAIYVETPTNPLLKITDIKKISTIAKEK 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 165 QLISVADNTFASPYLQRPLDLGFDVVVHSATKYLNGHSDVVAGVAAVGDnPALAEQLGFLQNAVGGILDPFSSFLTLRGV 244
Cdd:PRK07671 164 GLLTIVDNTFMTPYWQSPISLGADIVLHSATKYLGGHSDVVAGLVVVNS-PELAEDLHFVQNSTGGILGPQDSWLLLRGL 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 245 RTLALRMQRHSDSALRIAQWLESQPQVENVYYPGLPSHPQHELAARQMTRFGGMISVRLkGDDAYARRVIQRSRLFTLAE 324
Cdd:PRK07671 243 KTLGIRMEEHETNSRAIAEFLNNHPAVNKVYYPGLPSHPNHELAKEQANGFGGMISFDV-GSEETANKVLERLQYFTLAE 321
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 505190166 325 SLGGVESLISQPFSMTHASIPLEQRLATGITPQLVRLSVGIEDVEDLIADLQQALA 380
Cdd:PRK07671 322 SLGAVESLISIPSQMTHASIPADRRKELGITDGLIRISVGIEDGEDLIEDLAQALA 377
|
|
| PRK06176 |
PRK06176 |
cystathionine gamma-synthase; |
3-381 |
7.99e-160 |
|
cystathionine gamma-synthase;
Pssm-ID: 180443 [Multi-domain] Cd Length: 380 Bit Score: 453.59 E-value: 7.99e-160
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 3 KFDTLTVHAGYTPDAT-GAVMPAIYATSTYAQPAPGEHTGYEYSRSANPTRTALESAIAELEGGSRGYAFASGLAACSTV 81
Cdd:PRK06176 2 RMQTKLIHGGISEDTTtGAVSVPIYQTSTYRQDAIGRPKGYEYSRSGNPTRFALEELIADLEGGVKGFAFASGLAGIHAV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 82 LELLDKDSHLIAVDDLYGGTYRLLEKVRSRTaGLRVTYVAPADLAGLEQAIEPDTKMIWVETPTNPLLKLADLSAIAAIA 161
Cdd:PRK06176 82 FSLFQSGDHVLLGDDVYGGTFRLFDKVLVKN-GLSCTIIDTSDLSQIKKAIKPNTKALYLETPSNPLLKITDLAQCASVA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 162 KKHQLISVADNTFASPYLQRPLDLGFDVVVHSATKYLNGHSDVVAGVaAVGDNPALAEQLGFLQNAVGGILDPFSSFLTL 241
Cdd:PRK06176 161 KDHGLLTIVDNTFATPYYQNPLLLGADIVVHSGTKYLGGHSDVVAGL-VTTNNEALAQEIAFFQNAIGGVLGPQDSWLLQ 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 242 RGVRTLALRMQRHSDSALRIAQWLESQPQVENVYYPGLPSHPQHELAARQMTRFGGMISVRLKGDDAyARRVIQRSRLFT 321
Cdd:PRK06176 240 RGIKTLGLRMEAHQKNALCVAEFLEKHPKVEKVYYPGLPTHPNHELAKKQMRGFSGMLSFTLKNDSE-AVAFVESLKLFI 318
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 322 LAESLGGVESLISQPFSMTHASIPLEQRLATGITPQLVRLSVGIEDVEDLIADLQQALAE 381
Cdd:PRK06176 319 LGESLGGVESLVGIPAFMTHACIPKEQREAAGIRDGLVRLSVGIEHEQDLLEDLEQAFAK 378
|
|
| PRK08247 |
PRK08247 |
methionine biosynthesis PLP-dependent protein; |
1-380 |
4.42e-155 |
|
methionine biosynthesis PLP-dependent protein;
Pssm-ID: 181320 [Multi-domain] Cd Length: 366 Bit Score: 441.06 E-value: 4.42e-155
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 1 MAKFDTLTVHAG-YTPDATGAVMPAIYATSTYAQPAPGEHTGYEYSRSANPTRTALESAIAELEGGSRGYAFASGLAACS 79
Cdd:PRK08247 2 MSTIETKLAQIGnRSDERTGTVNPPVYFSTAYRHEGIGESTGFDYSRTGNPTRGVLEQAIADLEGGDQGFACSSGMAAIQ 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 80 TVLELLDKDSHLIAVDDLYGGTYRLLEKVRSRTaGLRVTYVAPADLAGLEQAIEPDTKMIWVETPTNPLLKLADLSAIAA 159
Cdd:PRK08247 82 LVMSLFRSGDELIVSSDLYGGTYRLFEEHWKKW-NVRFVYVNTASLKAIEQAITPNTKAIFIETPTNPLMQETDIAAIAK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 160 IAKKHQLISVADNTFASPYLQRPLDLGFDVVVHSATKYLNGHSDVVAGVaAVGDNPALAEQLGFLQNAVGGILDPFSSFL 239
Cdd:PRK08247 161 IAKKHGLLLIVDNTFYTPVLQRPLEEGADIVIHSATKYLGGHNDVLAGL-VVAKGQELCERLAYYQNAAGAVLSPFDSWL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 240 TLRGVRTLALRMQRHSDSALRIAQWLESQPQVENVYYPGLpshpqhelaarqmtrfGGMISVRLKgDDAYARRVIQRSRL 319
Cdd:PRK08247 240 LIRGMKTLALRMRQHEENAKAIAAFLNEQPGVTDVLYPGR----------------GGMLSFRLQ-DEEWVNPFLKSLKL 302
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 505190166 320 FTLAESLGGVESLISQPFSMTHASIPLEQRLATGITPQLVRLSVGIEDVEDLIADLQQALA 380
Cdd:PRK08247 303 ITFAESLGGVESFITYPATQTHADIPEEIRIANGVCNRLLRFSVGIENVEDLIADLKQAFK 363
|
|
| PRK08064 |
PRK08064 |
cystathionine beta-lyase MetC; |
4-381 |
1.54e-145 |
|
cystathionine beta-lyase MetC;
Pssm-ID: 236146 [Multi-domain] Cd Length: 390 Bit Score: 417.64 E-value: 1.54e-145
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 4 FDTLTVHAGYTPD-ATGAVMPAIYATSTYAQPAPGEHTGYEYSRSANPTRTALESAIAELEGGSRGYAFASGLAACSTVL 82
Cdd:PRK08064 7 IDTLLLHNQYKHDkQTGAVNVPIYHASTFHQFDFDTFGKYDYSRSGNPTREALEDIIAELEGGTKGFAFASGMAAISTAF 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 83 ELLDKDSHLIAVDDLYGGTYRLLEKVRSRTaGLRVTYVAPADLAGLEQAIEPDTKMIWVETPTNPLLKLADLSAIAAIAK 162
Cdd:PRK08064 87 LLLSKGDHVLISEDVYGGTYRMITEVLSRF-GIEHTFVDMTNLEEVAQNIKPNTKLFYVETPSNPLLKVTDIRGVVKLAK 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 163 KHQLISVADNTFASPYLQRPLDLGFDVVVHSATKYLNGHSDVVAGVAAVGDnPALAEQLGFLQNAVGGILDPFSSFLTLR 242
Cdd:PRK08064 166 AIGCLTFVDNTFLTPLLQKPLDLGADVVLHSATKFLAGHSDVLAGLAVVKD-EELAQKLYFLQNSFGAVLGVQDCWLVLR 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 243 GVRTLALRMQRHSDSALRIAQWLESQPQVENVYYPGLPSHPQHELAARQMTRFGGMISVRLKGDDAyARRVIQRSRLFTL 322
Cdd:PRK08064 245 GLKTLHVRLEHSSETANKIALYLQEHPKVQNVYYPGLQTHLGFDIQQSQATSAGAVLSFTLQSEEA-VRQFVSHVKLPVF 323
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 505190166 323 AESLGGVESLISQPFSMTHASIPLEQRLATGITPQLVRLSVGIEDVEDLIADLQQALAE 381
Cdd:PRK08064 324 AVSLGAVESILSYPAKMSHAAMPKEERDERGITDGLLRLSVGLENVDDLIADFEQALSY 382
|
|
| MET17 |
COG2873 |
O-acetylhomoserine/O-acetylserine sulfhydrylase, pyridoxal phosphate-dependent [Amino acid ... |
3-380 |
1.45e-139 |
|
O-acetylhomoserine/O-acetylserine sulfhydrylase, pyridoxal phosphate-dependent [Amino acid transport and metabolism]; O-acetylhomoserine/O-acetylserine sulfhydrylase, pyridoxal phosphate-dependent is part of the Pathway/BioSystem: Methionine biosynthesis
Pssm-ID: 442120 [Multi-domain] Cd Length: 428 Bit Score: 404.03 E-value: 1.45e-139
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 3 KFDTLTVHAGYTPD-ATGAVMPAIYATSTYAQPAPgEH---------TGYEYSRSANPTRTALESAIAELEGGSRGYAFA 72
Cdd:COG2873 7 GFETLALHAGQEPDpTTGARAVPIYQTTSYVFDDA-EHaadlfalkePGNIYTRIMNPTTDVLEKRIAALEGGVAALATA 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 73 SGLAACS-TVLELLDKDSHLIAVDDLYGGTYRLLEKVRSRtAGLRVTYVAPADLAGLEQAIEPDTKMIWVETPTNPLLKL 151
Cdd:COG2873 86 SGQAAITlAILNLAEAGDHIVASSSLYGGTYNLFAHTLPR-LGIEVRFVDPDDPEAFEAAIDPNTKAIFGETIGNPALDV 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 152 ADLSAIAAIAKKHQLISVADNTFASPYLQRPLDLGFDVVVHSATKYLNGHSDVVAGV---------AAVGDNPAL----- 217
Cdd:COG2873 165 LDIEAIAEIAHEHGVPLIVDNTFATPYLCRPIEHGADIVVHSATKYIGGHGTSIGGVivdggnfdwAANGKFPELtepdp 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 218 -------AEQLG---FLQNA-------VGGILDPFSSFLTLRGVRTLALRMQRHSDSALRIAQWLESQPQVENVYYPGLP 280
Cdd:COG2873 245 syhglvyTEAFGnaaFITKArvqllrdLGAALSPFNAFLLLQGLETLSLRMERHVENALKVAEFLEAHPKVAWVNYPGLP 324
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 281 SHPQHELAARQMTR-FGGMISVRLKGDDAYARRVIQRSRLFTLAESLGGVESLISQPFSMTHASIPLEQRLATGITPQLV 359
Cdd:COG2873 325 SHPYHELAQKYLPKgAGGVLTFGLKGGREAGKKFIDSLKLFSHLANIGDAKSLVIHPASTTHSQLSEEEQAAAGVTPDLI 404
|
410 420
....*....|....*....|.
gi 505190166 360 RLSVGIEDVEDLIADLQQALA 380
Cdd:COG2873 405 RLSVGIEDIDDIIADLDQALA 425
|
|
| O_succ_thio_ly |
TIGR02080 |
O-succinylhomoserine (thiol)-lyase; This family consists of O-succinylhomoserine (thiol)-lyase, ... |
6-380 |
9.22e-135 |
|
O-succinylhomoserine (thiol)-lyase; This family consists of O-succinylhomoserine (thiol)-lyase, one of three different enzymes designated cystathionine gamma-synthase and involved in methionine biosynthesis. In all three cases, sulfur is added by transsulfuration from Cys to yield cystathionine rather than by a sulfhydrylation step that uses H2S directly and bypasses cystathionine. [Amino acid biosynthesis, Aspartate family]
Pssm-ID: 131135 Cd Length: 382 Bit Score: 389.93 E-value: 9.22e-135
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 6 TLTVHAGYTPD-ATGAVMPAIYATSTYAQPAPGEHTGYEYSRSANPTRTALESAIAELEGGSRGYAFASGLAACSTV-LE 83
Cdd:TIGR02080 6 TIAVRSGLNSDtQYGCVVPPIYLSTTYNFTGFNEPRAYDYSRSGNPTRDLLQQALAELEGGAGAVVTNTGMSAIHLVtTA 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 84 LLDKDSHLIAVDDLYGGTYRLLeKVRSRTAGLRVTYVAPADLAGLEQAIEPDTKMIWVETPTNPLLKLADLSAIAAIAKK 163
Cdd:TIGR02080 86 LLGPDDLLVAPHDCYGGTYRLL-NALAKKGCFRVLFVDQGDEQALRAALAQKPKLVLIETPSNPLLRVVDIAKICHLAKA 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 164 HQLISVADNTFASPYLQRPLDLGFDVVVHSATKYLNGHSDVVAGvAAVGDNPALAEQLGFLQNAVGGILDPFSSFLTLRG 243
Cdd:TIGR02080 165 VGAVVVVDNTFLSPALQNPLALGADLVLHSCTKYLNGHSDVIAG-AVIAKDPQVAEELAWWANNLGVTGGAFDSYLTLRG 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 244 VRTLALRMQRHSDSALRIAQWLESQPQVENVYYPGLPSHPQHELAARQMTRFGGMISVRLKGDDAYARRVIQRSRLFTLA 323
Cdd:TIGR02080 244 LRTLVARMRLQQRNAQAIVEYLQTQPLVKKIYYPGLPDHPGHEIAARQQKGFGAMLSFELKGGEQTVRRFLGGLSLFTLA 323
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 505190166 324 ESLGGVESLISQPFSMTHASIPLEQRLATGITPQLVRLSVGIEDVEDLIADLQQALA 380
Cdd:TIGR02080 324 ESLGGVESLIAHPATMTHAAMGPEARAEAGISDTLLRLSVGLEDADDLIADLEQGLR 380
|
|
| PRK08133 |
PRK08133 |
O-succinylhomoserine sulfhydrylase; Validated |
4-380 |
3.54e-130 |
|
O-succinylhomoserine sulfhydrylase; Validated
Pssm-ID: 181244 [Multi-domain] Cd Length: 390 Bit Score: 378.58 E-value: 3.54e-130
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 4 FDTLTVHAGYTPDATGAVMPAIYATSTY-----AQPAP---GEHTGYEYSRSANPTRTALESAIAELEGGSRGYAFASGL 75
Cdd:PRK08133 7 FDTLAVRAGQLRSPFGEHSEALFLTSSFvfesaAEAAArfaGEEPGNIYSRFTNPTVTMFQERLAALEGAEACVATASGM 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 76 AAC-STVLELLDKDSHLIAVDDLYGGTYRLLEKVRSRTaGLRVTYVAPADLAGLEQAIEPDTKMIWVETPTNPLLKLADL 154
Cdd:PRK08133 87 AAIlAVVMALLQAGDHVVSSRSLFGSTVSLFEKIFARF-GIETTFVDLTDLDAWRAAVRPNTKLFFLETPSNPLTELADI 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 155 SAIAAIAKKHQLISVADNTFASPYLQRPLDLGFDVVVHSATKYLNGHSDVVAGvAAVGDNPALAEQLGFLQNAvGGILDP 234
Cdd:PRK08133 166 AALAEIAHAAGALLVVDNCFCTPALQQPLKLGADVVIHSATKYLDGQGRVLGG-AVVGSKELMEEVFGFLRTA-GPTLSP 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 235 FSSFLTLRGVRTLALRMQRHSDSALRIAQWLESQPQVENVYYPGLPSHPQHELAARQMTRFGGMISVRLKGDDAYARRVI 314
Cdd:PRK08133 244 FNAWVFLKGLETLSLRMEAHSANALALAEWLEAHPGVERVFYPGLPSHPQHELAKRQQKGGGAIVSFEVKGGREAAWRVI 323
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 505190166 315 QRSRLFTLAESLGGVESLISQPFSMTHASIPLEQRLATGITPQLVRLSVGIEDVEDLIADLQQALA 380
Cdd:PRK08133 324 DATRLISITANLGDTKTTITHPATTTHGRLSPEARAAAGITEGLIRVAVGLEDVADIKADLARGLA 389
|
|
| cysta_beta_ly_E |
TIGR01329 |
cystathionine beta-lyase, eukaryotic; This model represents cystathionine beta-lyase ... |
5-381 |
5.69e-130 |
|
cystathionine beta-lyase, eukaryotic; This model represents cystathionine beta-lyase (alternate name: beta-cystathionase), one of several pyridoxal-dependent enzymes of cysteine, methionine, and homocysteine metabolism. This enzyme is involved in the biosynthesis of Met from Cys.
Pssm-ID: 273557 [Multi-domain] Cd Length: 378 Bit Score: 377.63 E-value: 5.69e-130
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 5 DTLTVHAGYTPDATGAVMPAIYATSTYAQPAPGEHTGYEYSRSANPTRTALESAIAELEGGSRGYAFASGLAACSTVLEL 84
Cdd:TIGR01329 2 STLLVNTDNKNDPYDASSMPIYQTATFKQPLAIENGPYDYTRSGNPTRTALESLLAKLDKADRAFAFSSGMAALDVITRL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 85 LDKDSHLIAVDDLYGGTYRLLEKVRSRTaGLRVTYVAPADLAGLEQAIEPDTKMIWVETPTNPLLKLADLSAIAAIAKKH 164
Cdd:TIGR01329 82 LNNGDEIIAGDDLYGGTDRLLTQVVPRS-GVVVVHVDTTDLDKVKAALGPKTKLVLLESPTNPLQKIVDIRKISEMAHAQ 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 165 QLISVADNTFASPYLQRPLDLGFDVVVHSATKYLNGHSDVVAGVAAVGDnPALAEQLGFLQNAVGGILDPFSSFLTLRGV 244
Cdd:TIGR01329 161 NALVVVDNTMMSPLLCNPLELGADIVYHSATKFLAGHSDVMAGVLAVKG-EEIAKKVYFLQNSTGSGLAPFDCWLLLRGI 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 245 RTLALRMQRHSDSALRIAQWLESQPQVENVYYPGLPSHPQHELaARQMTRFGGMISVRLKGDDAYARRVIQRSRLFTLAE 324
Cdd:TIGR01329 240 KTLAIRIEKQQENARAIAMFLSTHPRVKKVRYAGLPSHPGFHL-HFSQAKGAGSVLSFETGSVALSKRLVEATKLFSITV 318
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 505190166 325 SLGGVESLISQPFSMTHASIPLEQRLATGITPQLVRLSVGIEDVEDLIADLQQALAE 381
Cdd:TIGR01329 319 SFGSVNSLISMPCFMSHASIPAEVREERGLPEDLVRLSVGIEDVDDLISDLDIAFVT 375
|
|
| PRK06767 |
PRK06767 |
methionine gamma-lyase; Provisional |
4-379 |
7.33e-128 |
|
methionine gamma-lyase; Provisional
Pssm-ID: 180685 [Multi-domain] Cd Length: 386 Bit Score: 372.64 E-value: 7.33e-128
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 4 FDTLTVHAGYTPDA-TGAVMPAIYATSTY--------AQPAPGEHTGYEYSRSANPTRTALESAIAELEGGSRGYAFASG 74
Cdd:PRK06767 6 METALIHHGYTSEEhKGSLTPPLFQTSTFtfetaqqgEASFAGVDPSYIYSRLGNPTVKLFEERMAVLEGGEEALAFGSG 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 75 LAACSTVL-ELLDKDSHLIAVDDLYGGTYRLLEKVRSRTAgLRVTYVAPADLAGLEQAIEPDTKMIWVETPTNPLLKLAD 153
Cdd:PRK06767 86 MAAISATLiGFLKAGDHIICSNGLYGCTYGFLEVLEEKFM-ITHSFCDMETEADIENKIRPNTKLIFVETPINPTMKLID 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 154 LSAIAAIAKKHQLISVADNTFASPYLQRPLDLGFDVVVHSATKYLNGHSDVVAGVaAVGDNPALAEQLGFLQNAVGGILD 233
Cdd:PRK06767 165 LKQVIRVAKRNGLLVIVDNTFCSPYLQRPLELGCDAVVHSATKYIGGHGDVVAGV-TICKTRALAEKIRPMRKDIGGIMA 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 234 PFSSFLTLRGVRTLALRMQRHSDSALRIAQWLESQPQVENVYYpglpshPQHELAARQMTRFGGMISVRLKGDDAYARRV 313
Cdd:PRK06767 244 PFDAWLLLRGLKTLAVRMDRHCDNAEKIVSFLKNHDAVEGVWY------PEGELASRQMKRGGGVISFSIKGGKEETQAF 317
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 505190166 314 IQRSRLFTLAESLGGVESLISQPFSMTHASIPLEQRLATGITPQLVRLSVGIEDVEDLIADLQQAL 379
Cdd:PRK06767 318 INDLHFITIAVSLGDTETLIQHPATMTHAAIPAELRQEMGIYDNLIRLSVGLESWEDIVSDLEQAL 383
|
|
| met_gam_lyase |
TIGR01328 |
methionine gamma-lyase; This model describes a methionine gamma-lyase subset of a family of ... |
4-379 |
1.39e-126 |
|
methionine gamma-lyase; This model describes a methionine gamma-lyase subset of a family of PLP-dependent trans-sulfuration enzymes. The member from the parasite Trichomonas vaginalis is described as catalyzing alpha gamma- and alpha-beta eliminations and gamma-replacement reactions on methionine, cysteine, and some derivatives. Likewise, the enzyme from Pseudomonas degrades cysteine as well as methionine. [Energy metabolism, Amino acids and amines]
Pssm-ID: 130395 [Multi-domain] Cd Length: 391 Bit Score: 369.60 E-value: 1.39e-126
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 4 FDTLTVHAGYTP-DATGAVMPAIYATSTYA--------QPAPGEHTGYEYSRSANPTRTALESAIAELEGGSRGYAFASG 74
Cdd:TIGR01328 4 FATRAIHAGYPPkDQFGALTPPIYQTSTFVfdsceqggNRFAGQESGYIYSRLGNPTVSNLEGRIAFLEGTEAAVATSSG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 75 LAACS-TVLELLDKDSHLIAVDDLYGGTYRLLEKVRSRTaGLRVTYVAPADLAGLEQAIEPDTKMIWVETPTNPLLKLAD 153
Cdd:TIGR01328 84 MGAIAaTLLTILKAGDHLISDECLYGCTFALLEHALTKF-GIQVDFINMAIPEEVKAHIKDNTKIVYFETPANPTMKLID 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 154 LSAIAAIAKKHQLISVADNTFASPYLQRPLDLGFDVVVHSATKYLNGHSDVVAGVAAvGDNPALAE-QLGFLQNAVGGIL 232
Cdd:TIGR01328 163 MERVCRDAHSQGVKVIVDNTFATPMLTNPVALGVDVVVHSATKYIGGHGDVVAGLIC-GKAELLQQiRMVGIKDMTGSVI 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 233 DPFSSFLTLRGVRTLALRMQRHSDSALRIAQWLESQPQVENVYYPGLPSHPQHELAARQMTRFGGMISVRLKGDDAYARR 312
Cdd:TIGR01328 242 SPFDAWLILRGLKTLNIRMKRHSENAMKVAEYLKSHPAVEKVYYPGFEDHPGHDIAAKQMRMGGGMITFELKGGFAGAKK 321
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 505190166 313 VIQRSRLFTLAESLGGVESLISQPFSMTHASIPLEQRLATGITPQLVRLSVGIEDVEDLIADLQQAL 379
Cdd:TIGR01328 322 LLNNLKLIRLAVSLGDAETLIQHPASMTHAVVPKEEREAAGITDGMIRLSVGLEDADDLIADLKQAL 388
|
|
| PRK06234 |
PRK06234 |
methionine gamma-lyase; Provisional |
4-379 |
5.38e-126 |
|
methionine gamma-lyase; Provisional
Pssm-ID: 168478 [Multi-domain] Cd Length: 400 Bit Score: 368.39 E-value: 5.38e-126
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 4 FDTLTVHAGYTPD-ATGAVMPAIYATSTYA--------QPAPGEHTGYEYSRSANPTRTALESAIAELEGGSRGYAFASG 74
Cdd:PRK06234 9 FATKAIHGGHIGDkQFGSLATPIYQTSTFIfdsaeqggRRFAGEESGYIYSRLGNPTSTEVENKLALLEGGEAAVVAASG 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 75 LAACSTVL-ELLDKDSHLIAVDDLYGGTYRLLEKVRSRTaGLRVTYVAPADLAGLEQAIEPDTKMIWVETPTNPLLKLAD 153
Cdd:PRK06234 89 MGAISSSLwSALKAGDHVVASDTLYGCTFALLNHGLTRY-GVEVTFVDTSNLEEVRNALKANTKVVYLETPANPTLKVTD 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 154 LSAIAAIAKKH--QLISVADNTFASPYLQRPLDLGFDVVVHSATKYLNGHSDVVAGVAaVGDNPALAEQLGF-LQNAVGG 230
Cdd:PRK06234 168 IKAISNIAHENnkECLVFVDNTFCTPYIQRPLQLGADVVVHSATKYLNGHGDVIAGFV-VGKEEFINQVKLFgIKDMTGS 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 231 ILDPFSSFLTLRGVRTLALRMQRHSDSALRIAQWLESQPQVENVYYPGLPSHPQHELAARQMTRFGGMISVRLKGDDAYA 310
Cdd:PRK06234 247 VIGPFEAFLIIRGMKTLQIRMEKHCKNAMKVAKFLESHPAVEKVYYPGLESFEYYELAKKQMSLPGAMISFELKGGVEEG 326
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 505190166 311 RRVIQRSRLFTLAESLGGVESLISQPFSMTHASIPLEQRLATGITPQLVRLSVGIEDVEDLIADLQQAL 379
Cdd:PRK06234 327 KVVMNNVKLATLAVSLGDAETLIQHPASMTHSPYTAEERKEAGISDGLVRLSVGLEDVDDIIADLKQAL 395
|
|
| PRK07503 |
PRK07503 |
methionine gamma-lyase; Provisional |
4-380 |
6.11e-126 |
|
methionine gamma-lyase; Provisional
Pssm-ID: 181005 [Multi-domain] Cd Length: 403 Bit Score: 368.36 E-value: 6.11e-126
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 4 FDTLTVHAGYTP-DATGAVMPAIYATSTYAQPA--------PGEHTGYEYSRSANPTRTALESAIAELEGGSRGYAFASG 74
Cdd:PRK07503 10 FSTRAIHHGYDPlDHGGALVPPVYLTATFAFPTaeygaecfAGEEEGHFYSRISNPTLALLEQRMASLEGGEAAVALASG 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 75 LAACSTVL-ELLDKDSHLIAVDDLYGGTYRLLEKVRSRTaGLRVTYVAPADLAGLEQAIEPDTKMIWVETPTNPLLKLAD 153
Cdd:PRK07503 90 MGAITATLwTLLRPGDEVIVDQTLYGCTFAFLHHGLGEF-GVTVRHVDLTDPAALKAAISDKTRMVYFETPANPNMRLVD 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 154 LSAIAAIAKKHQLISVADNTFASPYLQRPLDLGFDVVVHSATKYLNGHSDVVAGVAAVGDNPALAEQLGFLQNAVGGILD 233
Cdd:PRK07503 169 IAAVAEIAHGAGAKVVVDNTYCTPYLQRPLELGADLVVHSATKYLGGHGDITAGLVVGGKALADRIRLEGLKDMTGAVMS 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 234 PFSSFLTLRGVRTLALRMQRHSDSALRIAQWLESQPQVENVYYPGLPSHPQHELAARQMTRFGGMISVRLKGDDAYARRV 313
Cdd:PRK07503 249 PFDAFLLMRGLKTLALRMDRHCASAQAVAEWLARHPAVELVHYPGLPSFAQHALAQRQMALPGGMIAFELKGGIAAGRRF 328
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 505190166 314 IQRSRLFTLAESLGGVESLISQPFSMTHASIPLEQRLATGITPQLVRLSVGIEDVEDLIADLQQALA 380
Cdd:PRK07503 329 MNALQLFARAVSLGDAESLAQHPASMTHSTYTPEERAEHGISEGLVRLSVGLEDVADILADLAQALD 395
|
|
| PLN02509 |
PLN02509 |
cystathionine beta-lyase |
2-379 |
6.07e-122 |
|
cystathionine beta-lyase
Pssm-ID: 178125 [Multi-domain] Cd Length: 464 Bit Score: 360.50 E-value: 6.07e-122
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 2 AKFDTLTVHAGYTPDATGAVMPAIYATSTYAQPAPGEHTGYEYSRSANPTRTALESAIAELEGGSRGYAFASGLAACSTV 81
Cdd:PLN02509 85 ASVSTLLVNLDNKFDPFDAMSTPLYQTATFKQPSAIENGPYDYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAALSAV 164
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 82 LELLDKDSHLIAVDDLYGGTYRLLEKVRSRTaGLRVTYVAPADLAGLEQAIEPDTKMIWVETPTNPLLKLADLSAIAAIA 161
Cdd:PLN02509 165 THLIKNGEEIVAGDDVYGGSDRLLSQVVPRS-GVVVKRVNTTNLDEVAAAIGPQTKLVWLESPTNPRQQISDIRKIAEMA 243
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 162 KKHQLISVADNTFASPYLQRPLDLGFDVVVHSATKYLNGHSDVVAGVAAVgDNPALAEQLGFLQNAVGGILDPFSSFLTL 241
Cdd:PLN02509 244 HAQGALVLVDNSIMSPVLSRPLELGADIVMHSATKFIAGHSDVMAGVLAV-KGEKLAKEVYFLQNSEGSGLAPFDCWLCL 322
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 242 RGVRTLALRMQRHSDSALRIAQWLESQPQVENVYYPGLPSHPQHELAARQMTRFGGMISVrLKGDDAYARRVIQRSRLFT 321
Cdd:PLN02509 323 RGIKTMALRIEKQQENARKIAMYLSSHPRVKKVYYAGLPDHPGHHLHFSQAKGAGSVFSF-ITGSVALSKHLVETTKYFS 401
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 505190166 322 LAESLGGVESLISQPFSMTHASIPLEQRLATGITPQLVRLSVGIEDVEDLIADLQQAL 379
Cdd:PLN02509 402 IAVSFGSVKSLISMPCFMSHASIPAEVREARGLTEDLVRISAGIEDVDDLISDLDIAF 459
|
|
| OAH_OAS_sulfhy |
TIGR01326 |
OAH/OAS sulfhydrylase; This model describes a distinct clade of the Cys/Met metabolism ... |
3-380 |
4.88e-117 |
|
OAH/OAS sulfhydrylase; This model describes a distinct clade of the Cys/Met metabolism pyridoxal phosphate-dependent enzyme superfamily. Members include examples of OAH/OAS sulfhydrylase, an enzyme with activity both as O-acetylhomoserine (OAH) sulfhydrylase (EC 2.5.1.49) and O-acetylserine (OAS) sulphydrylase (EC 2.5.1.47). An alternate name for OAH sulfhydrylase is homocysteine synthase. This model is designated subfamily because it may or may not have both activities. [Amino acid biosynthesis, Aspartate family, Amino acid biosynthesis, Serine family]
Pssm-ID: 273555 [Multi-domain] Cd Length: 418 Bit Score: 346.27 E-value: 4.88e-117
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 3 KFDTLTVHAGYTPD-ATGAVMPAIYATSTYAQPAPgEH---------TGYEYSRSANPTRTALESAIAELEGGSRGYAFA 72
Cdd:TIGR01326 1 HFETLQLHAGQEPDpTTGSRAVPIYQTTSYVFDST-EHaaalfglqePGNIYSRLMNPTTDVLEQRIAALEGGVAALAVA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 73 SGLAACS-TVLELLDKDSHLIAVDDLYGGTYRLLeKVRSRTAGLRVTYVAPADLAGLEQAIEPDTKMIWVETPTNPLLKL 151
Cdd:TIGR01326 80 SGQAAITyAILNLAGAGDNIVSSSYLYGGTYNLF-SHTLKRLGIEVRFVDPDDPESLEKAIDENTKAVFAETIGNPQINV 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 152 ADLSAIAAIAKKHQLISVADNTFASPYLQRPLDLGFDVVVHSATKYLNGHSDVVAGVAAVGDN--------PAL------ 217
Cdd:TIGR01326 159 LDIEAIAEVAHRHGIPLIVDNTFATPYLCRPIKHGADIVVHSATKYIGGHGTAIGGVIVDGGKfdwnngrfPLFttpdps 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 218 ------AEQLGFLQNAV----------GGILDPFSSFLTLRGVRTLALRMQRHSDSALRIAQWLESQPQVENVYYPGLPS 281
Cdd:TIGR01326 239 yhglvfTETLGNPAFILkarvqllrdlGAALSPFNAFLLLQGLETLSLRMERHVENALKVAEFLESHPDVAWVNYPGLAS 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 282 HPQHELAARQMTR-FGGMISVRLKGDDAYARRVIQRSRLFTLAESLGGVESLISQPFSMTHASIPLEQRLATGITPQLVR 360
Cdd:TIGR01326 319 HPHHALAKKYLPKgFGAVLSFEIKGGREAGKKFIDALKLASHLANVGDAKSLVIHPASTTHSQLSEEEQLKAGVTPGLIR 398
|
410 420
....*....|....*....|
gi 505190166 361 LSVGIEDVEDLIADLQQALA 380
Cdd:TIGR01326 399 LSVGIENIDDIIADLEQALE 418
|
|
| PRK08861 |
PRK08861 |
O-succinylhomoserine (thiol)-lyase; |
6-380 |
1.43e-116 |
|
O-succinylhomoserine (thiol)-lyase;
Pssm-ID: 181567 [Multi-domain] Cd Length: 388 Bit Score: 344.19 E-value: 1.43e-116
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 6 TLTVHAGYTPDAT-GAVMPAIYATSTYAQPAPGEHTGYEYSRSANPTRTALESAIAELEGGSRGYAFASGLAACST-VLE 83
Cdd:PRK08861 8 TIAVRTGIESDSQyHAVVPPIYLSTNYGFPAFGEVPKYDYTRSGNPNRGLLEQTLSELESGKGAVVTNCGTSALNLwVSA 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 84 LLDKDSHLIAVDDLYGGTYRLLeKVRSRTAGLRVTYVAPADLAGLEQAIEPDTKMIWVETPTNPLLKLADLSAIAAIAKK 163
Cdd:PRK08861 88 LLGPDDLIVAPHDCYGGTYRLF-NTRANKGDFKVQFVDQSDAAALDAALAKKPKLILLETPSNPLVRVVDIAELCQKAKA 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 164 HQLISVADNTFASPYLQRPLDLGFDVVVHSATKYLNGHSDVVAGVAaVGDNPALAEQLGFLQNAVGGILDPFSSFLTLRG 243
Cdd:PRK08861 167 VGALVAVDNTFLTPVLQKPLELGADFVIHSTTKYINGHSDVIGGVL-ITKTKEHAEELAWWGNCIGATGTPFDSYMTLRG 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 244 VRTLALRMQRHSDSALRIAQWLESQPQVENVYYPGLPSHPQHELAARQMTRFGGMISVRLKGDDAYARRVIQRSRLFTLA 323
Cdd:PRK08861 246 IRTLGARMRVHEESAQQILAYLQTQSLVGTIYHPSLPEHPGHEIAKKQQSGFGSMLSFEFAGSFEQLKVFVKALALFSLA 325
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 505190166 324 ESLGGVESLISQPFSMTHASIPLEQRLATGITPQLVRLSVGIEDVEDLIADLQQALA 380
Cdd:PRK08861 326 ESLGGVESLICHPASMTHRAMGEEALAEAGVSQQLLRLSVGLEDAQDLIADLDQAFA 382
|
|
| PRK08249 |
PRK08249 |
cystathionine gamma-synthase family protein; |
2-380 |
1.08e-114 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 236202 [Multi-domain] Cd Length: 398 Bit Score: 339.41 E-value: 1.08e-114
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 2 AKFDTLTVHAGYTPD-ATGAVMPAIYATSTYA--------QPAPGEHTGYEYSRSANPTRTALESAIAELEGGSRGYAFA 72
Cdd:PRK08249 7 AGVGTKAVWAGEKEYlPYGATQVPVVLSVAYGyddidewyDVALGKKPGHIYSRNTNPTVQAFEEKVRILEGAEAATAFS 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 73 SGLAACSTVL-ELLDKDSHLIAVDDLYGGTYRLLEKVRSRtAGLRVTYVAPADLAGLEQAIEPDTKMIWVETPTNPLLKL 151
Cdd:PRK08249 87 TGMAAISNTLyTFLKPGDRVVSIKDTYGGTNKIFTEFLPR-MGVDVTLCETGDHEQIEAEIAKGCDLLYLETPTNPTLKI 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 152 ADLSAIAAIAKKHQLISVADNTFASPYLQRPLDLGFDVVVHSATKYLNGHSDVVAGVAaVGDNpALAEQLGFLQNAVGGI 231
Cdd:PRK08249 166 VDIERLAAAAKKVGALVVVDNTFATPINQNPLALGADLVIHSATKFLSGHADALGGVV-CGSK-ELMEQVYHYREINGAT 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 232 LDPFSSFLTLRGVRTLALRMQRHSDSALRIAQWLESQPQVENVYYPGLPSHPQHELAARQMTRFGGMISVRLKGDDAYAR 311
Cdd:PRK08249 244 MDPMSAYLILRGMKTLKLRVRQQQESAMALAKYLQTHPKVEAVYYPGLETHPNHEIAKAQMRGFGGILSFVLKGGMDTVK 323
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 505190166 312 RVIQRSRLFTLAESLGGVESLISQPFSMTHASIPLEQRLATGITPQLVRLSVGIEDVEDLIADLQQALA 380
Cdd:PRK08249 324 RLLPKLRYAHRAANLGAVETIYGPARTTSHVENTLEERAALGIPEGLVRISVGIEDTEDLIADLEQAFA 392
|
|
| PRK08776 |
PRK08776 |
O-succinylhomoserine (thiol)-lyase; |
6-380 |
8.90e-114 |
|
O-succinylhomoserine (thiol)-lyase;
Pssm-ID: 181554 [Multi-domain] Cd Length: 405 Bit Score: 337.73 E-value: 8.90e-114
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 6 TLTVHAGYTPD-ATGAVMPAIYATSTYAQPAPGEHTGYEYSRSANPTRTALESAIAELEGGSRGYAFASGLAACSTVLE- 83
Cdd:PRK08776 15 TAAVRAGIDRDtAYGAVTPPIVLSSNFSFDGFGNKRQYDYTRSGNPTRDLLGEALAELEGGAGGVITATGMGAINLVLNa 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 84 LLDKDSHLIAVDDLYGGTYRLLEKVRSRTAGLRVTyVAPADLAGLEQAIEPDTKMIWVETPTNPLLKLADLSAIAAIAKK 163
Cdd:PRK08776 95 LLQPGDTLVVPHDAYGGSWRLFNALAKKGHFALIT-ADLTDPRSLADALAQSPKLVLIETPSNPLLRITDLRFVIEAAHK 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 164 HQLISVADNTFASPYLQRPLDLGFDVVVHSATKYLNGHSDVVAGvAAVGDNPALAEQLGFLQNAVGGILDPFSSFLTLRG 243
Cdd:PRK08776 174 VGALTVVDNTFLSPALQKPLEFGADLVLHSTTKYINGHSDVVGG-AVVARDAELHQQLVWWANALGLTGSPFDAFLTLRG 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 244 VRTLALRMQRHSDSALRIAQWLESQPQVENVYYPGLPSHPQHELAARQMTRFGGMISVRLKGDDAYARRVIQRSRLFTLA 323
Cdd:PRK08776 253 LRTLDARLRVHQENADAIAALLDGHAAVNQVYYPGLASHPGHALAARQQKGFGAMLSFELEGGEAAVRAFVDGLRYFTLA 332
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 505190166 324 ESLGGVESLISQPFSMTHASIPLEQRLATGITPQLVRLSVGIEDVEDLIADLQQALA 380
Cdd:PRK08776 333 ESLGGVESLIAHPASMTHAAMTAEARAAAGISDGLLRLSVGIESAEDLLIDLRAGLA 389
|
|
| PRK08045 |
PRK08045 |
cystathionine gamma-synthase; Provisional |
6-379 |
2.66e-113 |
|
cystathionine gamma-synthase; Provisional
Pssm-ID: 169194 [Multi-domain] Cd Length: 386 Bit Score: 335.71 E-value: 2.66e-113
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 6 TLTVHAGYTPDAT-GAVMPAIYATSTYAQPAPGEHTGYEYSRSANPTRTALESAIAELEGGSRGYAFASGLAACSTVLEL 84
Cdd:PRK08045 7 TIAVRSGLNDDEQyGCVVPPIHLSSTYNFTGFNEPRAHDYSRRGNPTRDVVQRALAELEGGAGAVLTNTGMSAIHLVTTV 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 85 -LDKDSHLIAVDDLYGGTYRLLEKVRSRTAgLRVTYVAPADLAGLEQAIEPDTKMIWVETPTNPLLKLADLSAIAAIAKK 163
Cdd:PRK08045 87 fLKPGDLLVAPHDCYGGSYRLFDSLAKRGC-YRVLFVDQGDEQALRAALAEKPKLVLVESPSNPLLRVVDIAKICHLARE 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 164 HQLISVADNTFASPYLQRPLDLGFDVVVHSATKYLNGHSDVVAGvAAVGDNPALAEQLGFLQNAVGGILDPFSSFLTLRG 243
Cdd:PRK08045 166 AGAVSVVDNTFLSPALQNPLALGADLVLHSCTKYLNGHSDVVAG-VVIAKDPDVVTELAWWANNIGVTGGAFDSYLLLRG 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 244 VRTLALRMQRHSDSALRIAQWLESQPQVENVYYPGLPSHPQHELAARQMTRFGGMISVRLKGDDAYARRVIQRSRLFTLA 323
Cdd:PRK08045 245 LRTLVPRMELAQRNAQAIVKYLQTQPLVKKLYHPSLPENQGHEIAARQQKGFGAMLSFELDGDEQTLRRFLGGLSLFTLA 324
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 505190166 324 ESLGGVESLISQPFSMTHASIPLEQRLATGITPQLVRLSVGIEDVEDLIADLQQAL 379
Cdd:PRK08045 325 ESLGGVESLISHAATMTHAGMAPEARAAAGISETLLRISTGIEDGEDLIADLENGF 380
|
|
| PRK08574 |
PRK08574 |
cystathionine gamma-synthase family protein; |
6-379 |
5.20e-113 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 236298 [Multi-domain] Cd Length: 385 Bit Score: 334.73 E-value: 5.20e-113
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 6 TLTVHAGYTPDATGAVMPAIYATSTYAQPapGEH------TGYEYSRSANPTRTALESAIAELEGGSRGYAFASGLAACS 79
Cdd:PRK08574 5 TDAVRGYRGSDPYGSLQPPIYLTALFRQE--GEAypsdrgFDLKYSREENPTLRPLEEALAKLEGGVDALAFNSGMAAIS 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 80 TV-LELLDKDSHLIAVDDLYGGTYRLLEKVRSrtAGLRVTYVAPADLAGLEQAIEPDTKMIWVETPTNPLLKLADLSAIA 158
Cdd:PRK08574 83 TLfFSLLKAGDRVVLPMEAYGTTLRLLKSLEK--FGVKVVLAYPSTEDIIEAIKEGRTKLVFIETMTNPTLKVIDVPEVA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 159 AIAKKHQLISVADNTFASPYLQRPLDLGFDVVVHSATKYLNGHSDVVAGVAAVGDNPALaEQLGFLQNAVGGILDPFSSF 238
Cdd:PRK08574 161 KAAKELGAILVVDNTFATPLLYRPLRHGADFVVHSLTKYIAGHNDVVGGVAVAWSGEFL-EELWEWRRRLGTIMQPFEAY 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 239 LTLRGVRTLALRMQRHSDSALRIAQWLESQPQVENVYYPGLPSHPQHELAARQMTR--FGGMISVRLKGDDAYARRVIQR 316
Cdd:PRK08574 240 LVLRGLKTLEVRFERQCRNAMAIAEFLSEHPKVAEVYYPGLPSDPYHGVAKRLFGKdlYGGVVSFRVKGGRDAVLKFLRS 319
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 505190166 317 SRLFTLAESLGGVESLISQPFSMTHASIPLEQRLATGITPQLVRLSVGIEDVEDLIADLQQAL 379
Cdd:PRK08574 320 LKLIKPSPSLGGVESLATYPVKSAASPIPEEDRKALGITEDLVRLSVGLEDVEDLIEDLDQAL 382
|
|
| O_suc_HS_sulf |
TIGR01325 |
O-succinylhomoserine sulfhydrylase; This model describes O-succinylhomoserine sulfhydrylase, ... |
5-379 |
6.72e-112 |
|
O-succinylhomoserine sulfhydrylase; This model describes O-succinylhomoserine sulfhydrylase, one of several related pyridoxal phosphate-dependent enzymes of cysteine and methionine metabolism. This enzyme is part of an alternative pathway of homocysteine biosynthesis, a step in methionine biosynthesis. [Amino acid biosynthesis, Aspartate family]
Pssm-ID: 188131 Cd Length: 381 Bit Score: 331.81 E-value: 6.72e-112
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 5 DTLTVHAGYTPDATGAVMPAIYATSTY----AQPA----PGEHTGYEYSRSANPTRTALESAIAELEGGSRGYAFASGLA 76
Cdd:TIGR01325 1 ATLAVRGGMLRSGFEETAEALYLTSGYvydsAAVAakrfAGELPGFVYSRYGNPTVSVFEERLALLEGAEAAVATASGMA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 77 ACSTVL-ELLDKDSHLIAVDDLYGGTYRLLEKVRSRTaGLRVTYVAPADLAGLEQAIEPDTKMIWVETPTNPLLKLADLS 155
Cdd:TIGR01325 81 AIFAALmALLGAGDHVVASRSLFGSCFVVCSEILPRF-GVQTVFVDGTDLSAWEAALKPNTKAVFVETPSNPLQELVDIA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 156 AIAAIAKKHQLISVADNTFASPYLQRPLDLGFDVVVHSATKYLNGHSDVVAGVAAvGDNPALAEQLGFLQNAVGGILDPF 235
Cdd:TIGR01325 160 AVAELAHAAGAKVVVDNVFATPLLQQPLKLGADVVVYSATKHIDGQGRVLGGAIL-GSEEYMDEPVQKLLRHTGPAMSPF 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 236 SSFLTLRGVRTLALRMQRHSDSALRIAQWLESQPQVENVYYPGLPSHPQHELAARQMTRFGGMISVRLKGDDAyARRVIQ 315
Cdd:TIGR01325 239 NAWVLLKGLETLAIRVQHQNASALAIAEWLNGHPSVQWVYYPGLPSHPQHELAKRQMSGGGTVVTFDLDCRQA-AFKVLD 317
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 505190166 316 RSRLFTLAESLGGVESLISQPFSMTHASIPLEQRLATGITPQLVRLSVGIEDVEDLIADLQQAL 379
Cdd:TIGR01325 318 AMRLVDISNNLGDAKSTITHPATTTHRRMGPEERAAAGIGDGLVRLSVGLEDVDDLIADIDRAL 381
|
|
| PRK06460 |
PRK06460 |
hypothetical protein; Provisional |
16-380 |
1.27e-108 |
|
hypothetical protein; Provisional
Pssm-ID: 235807 [Multi-domain] Cd Length: 376 Bit Score: 323.32 E-value: 1.27e-108
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 16 DATGAVMPAIYATSTYAQPApGEHtgYEYSRSANPTRTALESAIAELEGGSRGYAFASGLAACSTV-LELLDKDSHLIAV 94
Cdd:PRK06460 14 EATGAITTPIYQTTAYHYPE-GEK--YRYSREANPTVLELTKKIVELENAEMGVAFSSGMGAISTTaLALLKPGNSVLVH 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 95 DDLYGGTYRLLEKVRsRTAGLRVTYVAPADLAGLEQAIEPDTKMIWVETPTNPLLKLADLSAIAAIAKKHQLISVADNTF 174
Cdd:PRK06460 91 RDMFGRSYRFFTDYL-KNWGVNVDASNPGSDNIIEKAKSKRYDVVFVENITNPLLRVVDITELSKVCKENGSILIVDATF 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 175 ASPYLQRPLDLGFDVVVHSATKYLNGHSDVVAGVAAvgDNPALAEQLGFLQNAVGGILDPFSSFLTLRGVRTLALRMQRH 254
Cdd:PRK06460 170 STPINQKPLELGADIVVHSASKFLAGHNDVIAGLAA--GYGKLLNVIDQMRRTLGTSLDPHAAYLTLRGIKTLKIRMDVI 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 255 SDSALRIAQWLESQPQVENVYYPGLPSHPQHELAARQMTRFGGMISVRLKGDDAYARRVIQRSRLFTLAESLGGVESLIS 334
Cdd:PRK06460 248 NRNAEQIAEFLEGHPKVVKVYYPGLKSHVDYEIARRVLKGFGGVLSFEVNGGQESALKVMKSLKLIIPAQTLGGVNSVIS 327
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 505190166 335 QPFSMTHASIPLEQRLATGITPQLVRLSVGIEDVEDLIADLQQALA 380
Cdd:PRK06460 328 HPATMSHRTLSLEERKIVGITDSLLRLSVGIEDVNDLIEDLDRALS 373
|
|
| PRK07269 |
PRK07269 |
cystathionine gamma-synthase; Reviewed |
3-379 |
1.34e-105 |
|
cystathionine gamma-synthase; Reviewed
Pssm-ID: 235983 Cd Length: 364 Bit Score: 315.22 E-value: 1.34e-105
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 3 KFDTLTVHAGYTPD-ATGAVMPAIYATSTYAQPAPGEHTGYEYSRSANPTRTALESAIAELEGGSRGYAFASGLAACSTV 81
Cdd:PRK07269 6 HINTILAQAGIKSDeATGALVTPLHFSTTYQHPEFGQSTGFDYTRTKNPTRAKLEETLAAIESADYALATSSGMSAIVLA 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 82 LELLDKDSHLIAVDDLYGGTYRLLEKVRSRTaglRVTYVAPADLAGLEQAIEPDTKMIWVETPTNPLLKLADLSAIAAIA 161
Cdd:PRK07269 86 FSVFPVGSKVVAVRDLYGGSFRWFNQQEKEG---RFHFTYANTEEELIAAIEEDTDIVYIETPTNPLMVEFDIEKVAKLA 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 162 KKHQLISVADNTFASPYLQRPLDLGFDVVVHSATKYLNGHSDVVAGVAAVGDnPALAEQLGFLQNAVGGILDPFSSFLTL 241
Cdd:PRK07269 163 HAKGAKVIVDNTFYSPIYQRPIELGADIVLHSATKYLSGHNDVLAGVVVTND-LELYEKLFYNLNTTGAVLSPFDSYLLM 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 242 RGVRTLALRMQRHSDSALRIAQWLESQPQVENVYYPGLpshpqhelaarqmtrfGGMISVRLKgDDAYARRVIQRSRLFT 321
Cdd:PRK07269 242 RGLKTLSLRMERSTANAQEVVAFLKKSPAVKEVLYTGK----------------GGMISFKVA-DETRIPHILNSLKVFT 304
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 505190166 322 LAESLGGVESLISQPFSMTHASIPLEQRLATGITPQLVRLSVGIEDVEDLIADLQQAL 379
Cdd:PRK07269 305 FAESLGGVESLITYPTTQTHADIPAEVRHSYGLTDDLLRLSIGIEDARDLIADLKQAL 362
|
|
| PRK05994 |
PRK05994 |
O-acetylhomoserine aminocarboxypropyltransferase; Validated |
3-380 |
3.06e-97 |
|
O-acetylhomoserine aminocarboxypropyltransferase; Validated
Pssm-ID: 180344 [Multi-domain] Cd Length: 427 Bit Score: 295.85 E-value: 3.06e-97
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 3 KFDTLTVHAGYTPD-ATGAVMPAIYATSTYAQPAPgEHT---------GYEYSRSANPTRTALESAIAELEGGSRGYAFA 72
Cdd:PRK05994 7 GFATLAVHAGAQPDpTTGARATPIYQTTSFVFNDA-DHAaslfglqafGNIYTRITNPTNAVLEERVAALEGGTAALAVA 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 73 SGLAACSTVLE-LLDKDSHLIAVDDLYGGTYRLLEKVrSRTAGLRVTYVAPADLAGLEQAIEPDTKMIWVETPTNPLLKL 151
Cdd:PRK05994 86 SGHAAQFLVFHtLLQPGDEFIAARKLYGGSINQFGHA-FKSFGWQVRWADADDPASFERAITPRTKAIFIESIANPGGTV 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 152 ADLSAIAAIAKKHQLISVADNTFASPYLQRPLDLGFDVVVHSATKYLNGHSDVVAGV---------AAVGDNPAL----- 217
Cdd:PRK05994 165 TDIAAIAEVAHRAGLPLIVDNTLASPYLIRPIEHGADIVVHSLTKFLGGHGNSMGGIivdggtfdwSKSGKYPMLseprp 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 218 -------AEQLGFLQNAV----------GGILDPFSSFLTLRGVRTLALRMQRHSDSALRIAQWLESQPQVENVYYPGLP 280
Cdd:PRK05994 245 eyhglvlHETFGNFAFAIaarvlglrdlGPAISPFNAFLILTGIETLPLRMQRHSDNALAVAEWLKGHPKVSWVNYAGLP 324
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 281 SHPQHELAARQMTRFGGMI-SVRLKGDDAYARRVIQRSRLFTLAESLGGVESLISQPFSMTHASIPLEQRLATGITPQLV 359
Cdd:PRK05994 325 DDPYHALAQKYSPKGAGAVfTFGLKGGYEAGVKLVSSLKLFSHLANIGDTRSLVIHPASTTHRQLTDEQKVAAGAGPDVV 404
|
410 420
....*....|....*....|.
gi 505190166 360 RLSVGIEDVEDLIADLQQALA 380
Cdd:PRK05994 405 RLSIGIEDVDDIIADLEQALA 425
|
|
| PRK06434 |
PRK06434 |
cystathionine gamma-lyase; Validated |
4-379 |
1.76e-95 |
|
cystathionine gamma-lyase; Validated
Pssm-ID: 102374 [Multi-domain] Cd Length: 384 Bit Score: 289.88 E-value: 1.76e-95
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 4 FDTLTVHAGYTPDAT-GAVMPAIYATSTYAQPAPG-----EHTG---YEYSRSANPTRTALESAIAELEGGSRGYAFASG 74
Cdd:PRK06434 9 FNTRAVQSGELRDPRfGNVTTPIFETSTFVYPNSEkeaymDSTRgmpYIYTRWGNPTVQAFEEKYAVLENAEHALSFSSG 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 75 LAA-CSTVLELLDKDSHLIAVDDLYGGTYRLLEKVRsRTAGLRVTYVAPADLAGLEqaIEP-DTKMIWVETPTNPLLKLA 152
Cdd:PRK06434 89 MGAiTSAILSLIKKGKRILSISDLYGQTFYFFNKVL-KTLGIHVDYIDTDRLNSLD--FDPsNYDLIYAESITNPTLKVP 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 153 DLSAIAAIAKKHQLIsvADNTFASPYLQRPLDLGFDVVVHSATKYLNGHSDVVAGVAAVgDNPALAEQLGFLQNAVGGIL 232
Cdd:PRK06434 166 DIKNVSSFCHENDVI--VDATFASPYNQNPLDLGADVVIHSATKYISGHSDVVMGVAGT-NNKSIFNNLVERRKTLGSNP 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 233 DPFSSFLTLRGVRTLALRMQRHSDSALRIAQWLESQPQVENVYYPGLpshpqhELAARQMTRFGGMISVRLKGDDAyARR 312
Cdd:PRK06434 243 DPIQAYLALRGLKTLGLRMEKHNKNGMELARFLRDSKKISNVYYPDT------EIGKKVLRGFGGMLSFELRSMED-VHK 315
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 505190166 313 VIQRSRLFTLAESLGGVESLISQPFSMTHASIPLEQRLATGITPQLVRLSVGIEDVEDLIADLQQAL 379
Cdd:PRK06434 316 FIRNLEIPMVAASLGGVESLITLPVETSHSSLSPEERERLGISDNLVRFSIGIEDIDDLIKDIENAL 382
|
|
| PRK08134 |
PRK08134 |
O-acetylhomoserine aminocarboxypropyltransferase; Validated |
3-379 |
1.30e-94 |
|
O-acetylhomoserine aminocarboxypropyltransferase; Validated
Pssm-ID: 236159 Cd Length: 433 Bit Score: 289.33 E-value: 1.30e-94
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 3 KFDTLTVHAGYTPD-ATGAVMPAIYATSTY----AQPAPG----EHTGYEYSRSANPTRTALESAIAELEGGSRGYAFAS 73
Cdd:PRK08134 8 GFDTLALHAGAAPDpATGARAVPIHLTTSFvfrdSDHAAAlfnlERAGHVYSRISNPTVAVLEERVAALEGGVGAIATAS 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 74 GLAACS-TVLELLDKDSHLIAVDDLYGGTYRLLEKVRSRTaGLRVTYVAPADLAGLEQAIEPDTKMIWVETPTNPLLKLA 152
Cdd:PRK08134 88 GQAALHlAIATLMGAGSHIVASSALYGGSHNLLHYTLRRF-GIETTFVKPGDIDGWRAAIRPNTRLLFGETLGNPGLEVL 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 153 DLSAIAAIAKKHQLISVADNTFASPYLQRPLDLGFDVVVHSATKYLNGHSDVVAGVA---------AVGDNPAL------ 217
Cdd:PRK08134 167 DIPTVAAIAHEAGVPLLVDSTFTTPYLLRPFEHGADLVYHSATKFLGGHGTAIGGVLvdggrfdweASGKFPELtepyag 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 218 ------AEQLG---FLQNA-------VGGILDPFSSFLTLRGVRTLALRMQRHSDSALRIAQWLESQPQVENVYYPGLPS 281
Cdd:PRK08134 247 fhgmvfAEESTvaaFLLRArreglrdFGACLSPMNAWQLLQGIETLPLRMERHVANTRKVVAFLASHPAVARVAHPELES 326
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 282 HPQHELAARQMTR-FGGMISVRLKGDDAYARRVIQRSRLFTLAESLGGVESLISQPFSMTHASIPLEQRLATGITPQLVR 360
Cdd:PRK08134 327 HPDHALAKRLLPRgAGSVFSFDLKGGRAAGRKFIESLKLFSHLANVGDARSLVIHPASTTHFRMDAAALAAAGIGEGTIR 406
|
410
....*....|....*....
gi 505190166 361 LSVGIEDVEDLIADLQQAL 379
Cdd:PRK08134 407 LSIGLEDADDLIDDLKRAL 425
|
|
| PRK07812 |
PRK07812 |
O-acetylhomoserine aminocarboxypropyltransferase; Validated |
4-380 |
9.43e-94 |
|
O-acetylhomoserine aminocarboxypropyltransferase; Validated
Pssm-ID: 236105 Cd Length: 436 Bit Score: 287.42 E-value: 9.43e-94
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 4 FDTLTVHAGYTPD-ATGAVMPAIYATSTY----AQPAPG----EHTGYEYSRSANPTRTALESAIAELEGGSRGYAFASG 74
Cdd:PRK07812 14 FETKQIHAGQTPDpATNARALPIYQTTSYtfddTDHAAAlfglAEPGNIYTRIMNPTQDVVEQRIAALEGGVAALLLASG 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 75 LAACS-TVLELLDKDSHLIAVDDLYGGTYRLLEKVRSRTaGLRVTYVA-PADLAGLEQAIEPDTKMIWVETPTNPLLKLA 152
Cdd:PRK07812 94 QAAETfAILNLAGAGDHIVSSPRLYGGTYNLFHYTLPKL-GIEVSFVEdPDDLDAWRAAVRPNTKAFFAETISNPQIDVL 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 153 DLSAIAAIAKKHQLISVADNTFASPYLQRPLDLGFDVVVHSATKYLNGHSDVVAGV------------------------ 208
Cdd:PRK07812 173 DIPGVAEVAHEAGVPLIVDNTIATPYLIRPLEHGADIVVHSATKYLGGHGTAIAGVivdggtfdwtqgrfpgfttpdpsy 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 209 -----AAVGDnPALAEQLGF-LQNAVGGILDPFSSFLTLRGVRTLALRMQRHSDSALRIAQWLESQPQVENVYYPGLPSH 282
Cdd:PRK07812 253 hgvvfAELGP-PAYALKARVqLLRDLGSAISPFNAFLIAQGLETLSLRIERHVANAQRVAEFLEARDEVASVNYAGLPSS 331
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 283 PQHELAARQMTR-FGGMISVRLKGDDAYARRVIQRSRLFTLAESLGGVESLISQPFSMTHASIPLEQRLATGITPQLVRL 361
Cdd:PRK07812 332 PWYERAKRLAPKgTGAVLSFELAGGVEAGKAFVNALTLHSHVANIGDVRSLVIHPASTTHSQLTPEEQLATGVTPGLVRL 411
|
410
....*....|....*....
gi 505190166 362 SVGIEDVEDLIADLQQALA 380
Cdd:PRK07812 412 AVGIEGIDDILADLEAGFA 430
|
|
| PRK05968 |
PRK05968 |
hypothetical protein; Provisional |
6-380 |
2.67e-91 |
|
hypothetical protein; Provisional
Pssm-ID: 168320 [Multi-domain] Cd Length: 389 Bit Score: 279.66 E-value: 2.67e-91
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 6 TLTVHAGytPDATGAVMPAIYATS-----TYAQPAP---GEHTGYEYSRSANPTRTALESAIAELEGGSRGYAFASGLAA 77
Cdd:PRK05968 13 LITAHDE--GNAFDAVVPPIFQTSlftfdSYDEMEDvyaGEKVRPIYSRGDNPTVRAFEEMLAKLEGAEDARGFASGMAA 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 78 -CSTVLELLDKDSHLIAVDDLYGGTYRLLEKVRSRTaGLRVTYVAPADLAGLEQAIePDTKMIWVETPTNPLLKLADLSA 156
Cdd:PRK05968 91 iSSTVLSFVEPGDRIVAVRHVYPDAFRLFETILKRM-GVEVDYVDGRDEEAVAKAL-PGAKLLYLESPTSWVFELQDVAA 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 157 IAAIAKKHQLISVADNTFASPYLQRPLDLGFDVVVHSATKYLNGHSDVVAGVAAvGDNPALAEQLGFLQNAVGGILDPFS 236
Cdd:PRK05968 169 LAALAKRHGVVTMIDNSWASPVFQRPITLGVDLVIHSASKYLGGHSDTVAGVVA-GSKEHIARINAEAYPYLGAKLSPFE 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 237 SFLTLRGVRTLALRMQRHSDSALRIAQWLESQPQVENVYYPGLPSHPQHELaarqmTRFGGMISVRLKgDDAYARRVIQR 316
Cdd:PRK05968 248 AWLLLRGLRTLPLRMKAHEASALEIARRLKAHPVVERVCHPALANHPPAGL-----SGTSGLFSFIFR-EGIDVRAFADA 321
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 317 SRLFTLAESLGGVESLIsqpfsmTHASIPLEQR------LATGITPQLVRLSVGIEDVEDLIADLQQALA 380
Cdd:PRK05968 322 LKLFRLGVSWGGHESLV------VPAEVVLQQKaqpnsaARFGVSPRSVRLHVGLEGTEALWADLEQALA 385
|
|
| PRK07582 |
PRK07582 |
cystathionine gamma-lyase; Validated |
6-381 |
5.13e-91 |
|
cystathionine gamma-lyase; Validated
Pssm-ID: 236061 Cd Length: 366 Bit Score: 278.03 E-value: 5.13e-91
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 6 TLTVHAGYTPDATGA-VMPAIYATSTYAQPAPGEHTGYEYSRSANPTRTALESAIAELEGGsRGYAFASGLAACSTVL-E 83
Cdd:PRK07582 6 TRSVHAGGPEAVPGEpVLPGPVFAAPYHLSPGEPTGPDTYGRASNPTWRALEAALGELEGA-EALVFPSGMAAITAVLrA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 84 LLDKDSHLIAVDDLYGGTYRLlekVRSRTAGLRVTyVAPADLAGLEQAIEPDTKMIWVETPTNPLLKLADLSAIAAIAKK 163
Cdd:PRK07582 85 LLRPGDTVVVPADGYYQVRAL---AREYLAPLGVT-VREAPTAGMAEAALAGADLVLAETPSNPGLDVCDLAALAAAAHA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 164 HQLISVADNTFASPYLQRPLDLGFDVVVHSATKYLNGHSDVVAGVAAVGDnPALAEQLGFLQNAVGGILDPFSSFLTLRG 243
Cdd:PRK07582 161 AGALLVVDNTTATPLGQRPLELGADLVVASDTKALTGHSDLLLGYVAGRD-PELMAAVERWRLLAGAIPGPFEAWLAHRS 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 244 VRTLALRMQRHSDSALRIAQWLESQPQVENVYYPGLPSHPQHELAARQMTRFGGMISVRLkGDDAYARRVIQRSRLFTLA 323
Cdd:PRK07582 240 LGTLGLRFARQCANALAVAELLAGHPAVRGVRYPGLPGDPAHEVAARQMRRFGGLVSFEL-ADAAAAERFVAASRLVVAA 318
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 505190166 324 ESLGGVeslisqpfsmtHASIPLEQRLATGITPQLVRLSVGIEDVEDLIADLQQALAE 381
Cdd:PRK07582 319 TSFGGV-----------HTSADRRARWGDAVPEGFVRLSCGIEDTDDLVADLERALDA 365
|
|
| PRK08248 |
PRK08248 |
homocysteine synthase; |
3-380 |
6.65e-91 |
|
homocysteine synthase;
Pssm-ID: 236201 [Multi-domain] Cd Length: 431 Bit Score: 279.81 E-value: 6.65e-91
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 3 KFDTLTVHAGYTPD-ATGAVMPAIYATSTY--------AQPAPGEHTGYEYSRSANPTRTALESAIAELEGGSRGYAFAS 73
Cdd:PRK08248 8 RLETLAIHAGQEIDpTTGSRAVPIYQTTSYgfrdsehaANLFSLKEFGNIYTRIMNPTTDVFEKRIAALEGGIGALAVSS 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 74 GLAACS-TVLELLDKDSHLIAVDDLYGGTYRLLEKVRSRTaGLRVTYVAPADLAGLEQAIEPDTKMIWVETPTNPLLKLA 152
Cdd:PRK08248 88 GQAAITySILNIASAGDEIVSSSSLYGGTYNLFAHTLPKL-GITVKFVDPSDPENFEAAITDKTKALFAETIGNPKGDVL 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 153 DLSAIAAIAKKHQLISVADNTFASPYLQRPLDLGFDVVVHSATKYLNGHSDVVAGV---------AAVGDNPALAE---- 219
Cdd:PRK08248 167 DIEAVAAIAHEHGIPLIVDNTFASPYLLRPIEHGADIVVHSATKFIGGHGTSIGGVivdsgkfdwKGSGKFPGLTEpdps 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 220 -----------QLGFLQNA-------VGGILDPFSSFLTLRGVRTLALRMQRHSDSALRIAQWLESQPQVENVYYPGLPS 281
Cdd:PRK08248 247 yhglvytdavgEAAYITKArvqllrdLGAALSPFNSFLLLQGLETLHLRMERHSENALAVAKFLEEHEAVEWVSYPGLPS 326
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 282 HPQHELAARQMTRFGGMI-SVRLKGDDAYARRVIQRSRLFTLAESLGGVESLISQPFSMTHASIPLEQRLATGITPQLVR 360
Cdd:PRK08248 327 HPSYELAKKYLPKGQGAIlTFGIKGGVEAGKKLIDSVKLFSHLANVGDSKSLIIHPASTTHQQLSEEEQLAAGVTPGLVR 406
|
410 420
....*....|....*....|
gi 505190166 361 LSVGIEDVEDLIADLQQALA 380
Cdd:PRK08248 407 LSVGTEAIDDILDDLRQAIR 426
|
|
| PRK07049 |
PRK07049 |
cystathionine gamma-synthase family protein; |
6-379 |
3.75e-88 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 180809 [Multi-domain] Cd Length: 427 Bit Score: 272.70 E-value: 3.75e-88
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 6 TLTVHAGYTPD-ATGAVMPAIYATSTYA------------------QPAPGEHTGYEYSRSANPTRTALESAIAELEGGS 66
Cdd:PRK07049 20 TQMLNYGYDPElSEGAVKPPVFLTSTFVfrsaedgrdffdyvsgrkEPPAGEGAGLVYSRFNHPNSEIVEDRLAVYEGAE 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 67 RGYAFASGLAACSTV-LELLDKDSHLIAVDDLYGGTYRLLEKVRSRTAGLRVTYVAPADLAGLEQAIEP-----DTKMIW 140
Cdd:PRK07049 100 SAALFSSGMSAIATTlLAFVRPGDVILHSQPLYGGTETLLAKTFRNFGVGAVGFADGLSEAAIGAAAEAaaakgRVSLIL 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 141 VETPTNPLLKLADLSAIAAIAKK------HQLISVADNTFASPYLQRPLDLGFDVVVHSATKYLNGHSDVVAGvAAVGDN 214
Cdd:PRK07049 180 IETPANPTNSLVDVAAVRRVADAiearqgHRPIIACDNTLLGPVFQKPLEHGADLSVYSLTKYVGGHSDLVAG-AVLGRK 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 215 pALAEQLGFLQNAVGGILDPFSSFLTLRGVRTLALRMQRHSDSALRIAQWLESQPQVENVYYPGL--PSHPQHELAARQM 292
Cdd:PRK07049 259 -ALIRQVRALRSAIGTQLDPHSCWMLGRSLETLVLRMERANRNARAVAEFLRDHPKVEKLHYLPFldPDSAYGAVYKRQC 337
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 293 TRFGGMISVRLKGDDAYARRVIQRSRLFTLAESLGGVESLISQPFSMTHASIPLEQRLATGITPQLVRLSVGIEDVEDLI 372
Cdd:PRK07049 338 TGAGSTFSFDIKGGQAAAFRFLNALQIFKLAVSLGGTESLASHPASMTHSGVPADVRERIGVLESTIRLSIGIEHPDDLI 417
|
....*..
gi 505190166 373 ADLQQAL 379
Cdd:PRK07049 418 ADLAQAL 424
|
|
| PRK07810 |
PRK07810 |
O-succinylhomoserine sulfhydrylase; Provisional |
5-380 |
1.83e-85 |
|
O-succinylhomoserine sulfhydrylase; Provisional
Pssm-ID: 236103 [Multi-domain] Cd Length: 403 Bit Score: 265.06 E-value: 1.83e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 5 DTLTVHAGYTPDATGAVMPAIYATSTY----AQPAPGEHTG----YEYSRSANPTRTALESAIAELEGGSRGYAFASGLA 76
Cdd:PRK07810 17 ATIGVRGGLLRSGFEETAEALYLTSGYvyesAAAAEAAFTGeldrFVYSRYGNPTVSMFEERLRLIEGAEACFATASGMS 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 77 ACSTVL-ELLDKDSHLIAVDDLYGGTYRLLEKVRSRTaGLRVTYVAPADLAGLEQAIEPDTKMIWVETPTNPLLKLADLS 155
Cdd:PRK07810 97 AVFTALgALLGAGDRLVAARSLFGSCFVVCNEILPRW-GVETVFVDGEDLSQWEEALSVPTQAVFFETPSNPMQSLVDIA 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 156 AIAAIAKKHQLISVADNTFASPYLQRPLDLGFDVVVHSATKYLNGHSDVVAGvAAVGDNPALAEQLGFLQNAVGGILDPF 235
Cdd:PRK07810 176 AVSELAHAAGAKVVLDNVFATPLLQRGLPLGADVVVYSGTKHIDGQGRVLGG-AILGDREYIDGPVQKLMRHTGPALSAF 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 236 SSFLTLRGVRTLALRMQRHSDSALRIAQWLESQPQVENVYYPGLPSHPQHELAARQMTRFGGMISVRLKGDDAYARR--- 312
Cdd:PRK07810 255 NAWVLLKGLETLALRVRHSNASALRIAEFLEGHPAVRWVRYPFLPSHPQYDLAKRQMSGGGTVVTFELDAPEDAAKKraf 334
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 505190166 313 -VIQRSRLFTLAESLGGVESLISQPFSMTHASIPLEQRLATGITPQLVRLSVGIEDVEDLIADLQQALA 380
Cdd:PRK07810 335 eVLDKLRVIDISNNLGDAKSLITHPATTTHRAMGPEGRAAIGLGDGVVRLSVGLEDTDDLIADLDRALG 403
|
|
| PRK05939 |
PRK05939 |
cystathionine gamma-synthase family protein; |
19-380 |
3.34e-85 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 235650 [Multi-domain] Cd Length: 397 Bit Score: 264.24 E-value: 3.34e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 19 GAVMPAIYATSTYA-----------QpapGEHTGYEYSRSANPTRTALESAIAELEGGSRGYAFASGLAA-CSTVLELLD 86
Cdd:PRK05939 8 GAVHKPIHTSVTYGyedardlidvfQ---GKKPGFTYARQGTPTTAALEAKITKMEGGVGTVCFATGMAAiAAVFLTLLR 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 87 KDSHLIAVDDLYGGTYRLLEKVRSRtaGLRVTYVAPADLAGLEQAIEPDTKMIWVETPTNPLLKLADLSAIAAIAKKHQL 166
Cdd:PRK05939 85 AGDHLVSSQFLFGNTNSLFGTLRGL--GVEVTMVDATDVQNVAAAIRPNTRMVFVETIANPGTQVADLAGIGALCRERGL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 167 ISVADNTFASPYLQRPLDLGFDVVVHSATKYLNGHSDVVAGvaAVGDN--------PALAE--------QLGFLQ----- 225
Cdd:PRK05939 163 LYVVDNTMTSPWLFRPKDVGASLVINSLSKYIAGHGNALGG--AVTDTglfdwsayPNIFPayrkgdpqQWGLTQirkkg 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 226 -NAVGGILDPFSSFLTLRGVRTLALRMQRHSDSALRIAQWLESQPQVENVYYPGLPSHPQHELAARQMTRFGGMISVRLK 304
Cdd:PRK05939 241 lRDMGATLSSEAAHRIAIGAETLALRVDRSCSNALALAQFLEAHPKVARVYYPGLASHPQHARATELFRHYGGLLSFELA 320
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 505190166 305 -GDDAYArrVIQRSRLFTLAESLGGVESLISQPFSMTHASIPLEQRLATGITPQLVRLSVGIEDVEDLIADLQQALA 380
Cdd:PRK05939 321 dGIDCFD--FLNRLKLVIKATHLGDTRTLVIPVAPTIYYEMGAERRASMGIADSLIRVSVGIEDEADLIADFEQALD 395
|
|
| PRK06084 |
PRK06084 |
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase; |
3-380 |
1.62e-84 |
|
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase;
Pssm-ID: 180392 [Multi-domain] Cd Length: 425 Bit Score: 263.30 E-value: 1.62e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 3 KFDTLTVHAGYTPD-ATGAVMPAIYATSTYAQPAPgEH---------TGYEYSRSANPTRTALESAIAELEGGSRGYAFA 72
Cdd:PRK06084 2 KLETLAIHAGYSPDpTTKAVAVPIYQTTSYAFDDT-QHgadlfdlkvPGNIYTRIMNPTNDVLEQRVAALEGGVGALAVA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 73 SGLAACSTVLELL-DKDSHLIAVDDLYGGTYRLLEKVRSRTaGLRVTYVAPADLAGLEQAIEPDTKMIWVETPTNPLLKL 151
Cdd:PRK06084 81 SGMAAITYAIQTIaEAGDNIVSVAKLYGGTYNLLAHTLPRI-GIETRFAAHDDIAALEALIDERTKAVFCESIGNPAGNI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 152 ADLSAIAAIAKKHQLISVADNTFASPYLQRPLDLGFDVVVHSATKYLNGHSDVVAGVAAVGDNPALAE------------ 219
Cdd:PRK06084 160 IDIQALADAAHRHGVPLIVDNTVATPVLCRPFEHGADIVVHSLTKYIGGHGTSIGGIVVDSGKFPWAEhkerfallntpd 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 220 ---------------------QLGFLQNaVGGILDPFSSFLTLRGVRTLALRMQRHSDSALRIAQWLESQPQVENVYYPG 278
Cdd:PRK06084 240 psyhgvtyteafgpaafigrcRVVPLRN-MGAALSPFNAFLILQGLETLALRMERHTENALKVARYLQQHPQVAWVKYAG 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 279 LPSHPQHELAARQMT-RFGGMISVRLKGDDAYARRVIQRSRLFTLAESLGGVESLISQPFSMTHASIPLEQRLATGITPQ 357
Cdd:PRK06084 319 LPDHPEHELARRYMGgKPASILSFGIKGGQAAGARFIDALKLVVRLVNIGDAKSLACHPASTTHRQLNDEELEKAGVSRD 398
|
410 420
....*....|....*....|...
gi 505190166 358 LVRLSVGIEDVEDLIADLQQALA 380
Cdd:PRK06084 399 MVRLSIGIEHIDDIIADLAQALD 421
|
|
| PRK07504 |
PRK07504 |
O-succinylhomoserine sulfhydrylase; Reviewed |
6-380 |
5.60e-81 |
|
O-succinylhomoserine sulfhydrylase; Reviewed
Pssm-ID: 168979 [Multi-domain] Cd Length: 398 Bit Score: 253.14 E-value: 5.60e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 6 TLTVHAGYTPDATGAVMPAIYATSTYAQPAP--------GEHTGYEYSRSANPTRTALESAIAELEGGSRGYAFASGLAA 77
Cdd:PRK07504 13 TRLVHSGTLRSQFGETSEALFLTQGFVYDTAeaaearfkGEDPGFIYSRYSNPTVDMFEKRMCALEGAEDARATASGMAA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 78 CST-VLELLDKDSHLIAVDDLYGGTYRLLEKVRSRTaGLRVTYVAPADLAGLEQAIEPDTKMIWVETPTNPLLKLADLSA 156
Cdd:PRK07504 93 VTAaILCQVKAGDHVVAARALFGSCRYVVETLLPRY-GIESTLVDGLDLDNWEKAVRPNTKVFFLESPTNPTLEVIDIAA 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 157 IAAIAKKHQLISVADNTFASPYLQRPLDLGFDVVVHSATKYLNGHSDVVAGVAaVGDNPALAEQLGFLQNAVGGILDPFS 236
Cdd:PRK07504 172 VAKIANQAGAKLVVDNVFATPLFQKPLELGAHIVVYSATKHIDGQGRCLGGVV-LSDKAWIEEHLQDYFRHTGPSLSPFN 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 237 SFLTLRGVRTLALRMQRHSDSALRIAQWLESQPQVENVYYPGLPSHPQHELAARQMTRFGGMISVRLKGDDAYARRVIQR 316
Cdd:PRK07504 251 AWTLLKGLETLPVRVRQQTESAAAIADFLAGHPKVARVIYPGRADHPQADIIAKQMTGGSTLVAFELKGGKEAAFRFLNA 330
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 505190166 317 SRLFTLAESLGGVESLISQPFSMTHASIPLEQRLATGITPQLVRLSVGIEDVEDLIADLQQALA 380
Cdd:PRK07504 331 LKIVRISNNLGDAKSLITHPATTTHKNLSPEARAELGISEGFLRLSAGLEDTDDLIEDLAAALK 394
|
|
| PRK05967 |
PRK05967 |
cystathionine beta-lyase; Provisional |
5-380 |
5.24e-74 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 235657 [Multi-domain] Cd Length: 395 Bit Score: 235.09 E-value: 5.24e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 5 DTLTVHAGYTP-DATGAVMPAIYATSTY----AQPAPGEHTGYEYSRSANPTRTALESAIAELEGGSRGYAFASGLAACS 79
Cdd:PRK05967 14 NTRLAHDGNDPgDYHGFVNPPVVHASTVlfpdAETMATRGQKYTYGTRGTPTTDALCKAIDALEGSAGTILVPSGLAAVT 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 80 T-VLELLDKDSHLIAVDDLYGGTYRLLEKVRSRTaGLRVTYVAPADLAGLEQAIEPDTKMIWVETPTNPLLKLADLSAIA 158
Cdd:PRK05967 94 VpFLGFLSPGDHALIVDSVYYPTRHFCDTMLKRL-GVEVEYYDPEIGAGIAKLMRPNTKVVHTEAPGSNTFEMQDIPAIA 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 159 AIAKKHQLISVADNTFASPYLQRPLDLGFDVVVHSATKYLNGHSDVVAGVaaVGDNPALAEQLGFLQNAVGGILDPFSSF 238
Cdd:PRK05967 173 EAAHRHGAIVMMDNTWATPLYFRPLDFGVDISIHAATKYPSGHSDILLGT--VSANEKCWPQLLEAHGTLGLCAGPDDTY 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 239 LTLRGVRTLALRMQRHSDSALRIAQWLESQPQVENVYYPGLPSHPQHELAARQMTRFGGMISVRLKGDD----AYARRVI 314
Cdd:PRK05967 251 QILRGLRTMGIRLEHHRKSALEIARWLEGRPDVARVLHPALPSFPGHEIWKRDFSGASGIFSFVLAAGPekgkAKAHAFL 330
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 505190166 315 QRSRLFTLAESLGGVESLisqpfsMTHASIPlEQRLATGITP-QLVRLSVGIEDVEDLIADLQQALA 380
Cdd:PRK05967 331 DALEIFGLGYSWGGYESL------ALHVKLG-DRTVAKAPYAgPVIRLQIGLEDVPDLKADLERGFA 390
|
|
| cysta_beta_ly_B |
TIGR01324 |
cystathionine beta-lyase, bacterial; This model represents cystathionine beta-lyase (alternate ... |
6-380 |
3.61e-70 |
|
cystathionine beta-lyase, bacterial; This model represents cystathionine beta-lyase (alternate name: beta-cystathionase), one of several pyridoxal-dependent enzymes of cysteine, methionine, and homocysteine metabolism. This enzyme is involved in the biosynthesis of Met from Cys. [Amino acid biosynthesis, Aspartate family]
Pssm-ID: 130391 [Multi-domain] Cd Length: 377 Bit Score: 224.76 E-value: 3.61e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 6 TLTVHAGYTP-DATGAVMPAIYATSTYAQPAPGEHTG----YEYSRSANPTRTALESAIAELEGGSRGYAFASGLAACS- 79
Cdd:TIGR01324 1 TRLIHSGRQPrFSQGSVNPPLQRASTVLFDSHAAQRRakgeLTYGRRGTLTHFALQDAMCELEGGAGCYLYPSGLAAVTn 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 80 TVLELLDKDSHLIAVDDLYGGTYRLLEKVRSRTaGLRVTYVAPADLAGLEQAIEPDTKMIWVETPTNPLLKLADLSAIAA 159
Cdd:TIGR01324 81 SILAFVKAGDHVLMVDSAYEPTRYFCDIVLKRM-GVDITYYDPLIGEDIATLIQPNTKVLFLEAPSSITFEIQDIPAIAK 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 160 IAKKHQLISVADNTFASPYLQRPLDLGFDVVVHSATKYLNGHSDVVAGVAAVgdNPALAEQLGFLQNAVGGILDPFSSFL 239
Cdd:TIGR01324 160 AARNPGIVIMIDNTWAAGLLFKPLEHGVDISIQAGTKYLVGHSDIMIGTVVA--NARTWDQLREHSYLMGQMVDADDAYT 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 240 TLRGVRTLALRMQRHSDSALRIAQWLESQPQVENVYYPGLPSHPQHELAARQMTRFGGMISVRLKGDDAYARRVIQRS-R 318
Cdd:TIGR01324 238 TLRGLRTLGVRLKQHQESSLAIAKWLSEQPEVARVLHPALPSCPGHEFWKRDFSGSSGLFSFVLQRLTQKQVHAFLDHlQ 317
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 505190166 319 LFTLAESLGGVESLI--SQPFSMTHASIPLEqrlatgITPQLVRLSVGIEDVEDLIADLQQALA 380
Cdd:TIGR01324 318 LFGLGYSWGGYESLAlcNQPELGHRPNIKRN------LEGPLIRVHIGLENVDDLKADLKAGFE 375
|
|
| PRK05613 |
PRK05613 |
O-acetylhomoserine/O-acetylserine sulfhydrylase; |
4-380 |
3.56e-69 |
|
O-acetylhomoserine/O-acetylserine sulfhydrylase;
Pssm-ID: 168128 [Multi-domain] Cd Length: 437 Bit Score: 223.98 E-value: 3.56e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 4 FDTLTVHAGYTPDA-TGAVMPAIYATSTY--------AQPAPGEHTGYEYSRSANPTRTALESAIAELEGGSRGYAFASG 74
Cdd:PRK05613 14 FETRSIHAGQSVDSdTSARNLPIYQTTSYvfdsaehaKQRFALEDLGPIYSRLTNPTVEALENRIASLEGGVHAVAFASG 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 75 LAA-CSTVLELLDKDSHLIAVDDLYGGTYRLLEKVRSRTaGLRVTYVA-PADLAGLEQAIEPDTKMIWVETPTNPLLKLA 152
Cdd:PRK05613 94 QAAeTAAILNLAGAGDHIVTSPRLYGGTETLFLVTLNRL-GIEVTFVEnPDDPESWQAAVQPNTKAFFGETFANPQADVL 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 153 DLSAIAAIAKKHQLISVADNTFASPYLQRPLDLGFDVVVHSATKYLNGHSDVVAGVAAVGDN------------------ 214
Cdd:PRK05613 173 DIPAVAEVAHRNQVPLIVDNTIATAALVRPLELGADVVVASLTKFYTGNGSGLGGVLIDGGKfdwtverdgkpvfpyfvt 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 215 --PA---------------LAEQLGFLQNaVGGILDPFSSFLTLRGVRTLALRMQRHSDSALRIAQWLESQPQVENVYYP 277
Cdd:PRK05613 253 pdPAyhglkyadlgapafgLKARAGLLRD-TGATLSPFNAWVTAQGLDTLSLRLERHNENAIKVAEFLNNHEKVAKVNFA 331
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 278 GLPSHPQHELAARQMTRF-GGMISVRLKGDDAYARRVIQRSRLFTLAESLGGVESLISQPFSMTHASIPLEQRLATGITP 356
Cdd:PRK05613 332 GLKDSPWYATKEKLGLKYtGSVLSFDIKGGKDEAWAFIDALKLHSNLANIGDVRSLVVHPATTTHSQSDEAGLARAGITQ 411
|
410 420
....*....|....*....|....
gi 505190166 357 QLVRLSVGIEDVEDLIADLQQALA 380
Cdd:PRK05613 412 ATVRLSVGIEDIDDIIADLEGGFA 435
|
|
| PRK09028 |
PRK09028 |
cystathionine beta-lyase; Provisional |
44-380 |
5.42e-68 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 181615 [Multi-domain] Cd Length: 394 Bit Score: 219.61 E-value: 5.42e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 44 YSRSANPTRTALESAIAELEGGSRGYAFASGLAACS-TVLELLDKDSHLIAVDDLYGGTYRLLEKVRSRTaGLRVTYVAP 122
Cdd:PRK09028 55 YGRRGTPTHFAFQAAIVELEGGAGTALYPSGAAAISnALLSFLKAGDHLLMVDSCYEPTRDLCDKILKGF-GIETTYYDP 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 123 ADLAGLEQAIEPDTKMIWVETPTNPLLKLADLSAIAAIAKKHQLISVADNTFASPYLQRPLDLGFDVVVHSATKYLNGHS 202
Cdd:PRK09028 134 MIGEGIRELIRPNTKVLFLESPGSITMEVQDVPTLSRIAHEHDIVVMLDNTWASPINSRPFEMGVDISIQAATKYIVGHS 213
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 203 DVVAGVAAVgdNPALAEQLGFLQNAVGGILDPFSSFLTLRGVRTLALRMQRHSDSALRIAQWLESQPQVENVYYPGLPSH 282
Cdd:PRK09028 214 DVMLGTATA--NEKHWDQLREHSYLMGQCTSPDDVYLAMRGLRTLGVRLAQHEKNALKVANWLATRPEVDHVRHPAFETC 291
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 283 PQHELAARQMTRFGGMISVRLK-GDDAYARRVIQRSRLFTLAESLGGVESLISQPFSMThasipleqRLATGITPQ---- 357
Cdd:PRK09028 292 PGHEFFKRDFSGSNGLFSFVLKqGDPKAVTALVEGMQHFKMGFSWGGFESLILGVFGIN--------KLRTATNWDfskp 363
|
330 340
....*....|....*....|...
gi 505190166 358 LVRLSVGIEDVEDLIADLQQALA 380
Cdd:PRK09028 364 LIRLHIGLEDVDDLIADLEAGFE 386
|
|
| PLN02242 |
PLN02242 |
methionine gamma-lyase |
19-381 |
2.02e-65 |
|
methionine gamma-lyase
Pssm-ID: 215134 Cd Length: 418 Bit Score: 213.86 E-value: 2.02e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 19 GAVMPAIYATSTYAQPAP-----------GEHTG-YEYSRSANPTRTALESAIAELEGGSRGYAFASGLAACSTV-LELL 85
Cdd:PLN02242 33 GGVNMSIEASATFTVMEPdtmrrmfsgelGPDRDfYIYSRHFNPTVLNLGRQMAALEGTEAAYCTASGMSAISSVlLQLC 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 86 DKDSHLIAVDDLYGGTYRLLEKVRSRTAGLRVTYVAPADLAGLEQAIEP-DTKMIWVETPTNPLLKLADLSAIAAIAKKH 164
Cdd:PLN02242 113 SSGGHVVASNTLYGGTHALLAHFLPRKCNITTTFVDITDLEAVKKAVVPgKTKVLYFESISNPTLTVADIPELARIAHEK 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 165 QLISVADNTFAsPYLQRPLDLGFDVVVHSATKYLNGHSDVVAGvAAVGDNPALAEQLGFLQNAV---GGILDPFSSF-LT 240
Cdd:PLN02242 193 GVTVVVDNTFA-PMVLSPARLGADVVVHSISKFISGGADIIAG-AVCGPAELVNSMMDLHHGALmllGPTMNPKVAFeLS 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 241 LRgVRTLALRMQRHSDSALRIAQWLESQPQveNVYYPGLPSHPQHELAARQMTR---FGGMISVRLKGDDAYAR--RVIQ 315
Cdd:PLN02242 271 ER-LPHLSLRMKEHCRRAMEYAKRMKELGL--KVIYPGLEDHPQHALLKSMANKgygFGGLLCLDMDTEERANRlmRYLQ 347
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 505190166 316 RSRLFTL-AESLGGVESLISQPFSMTHASIPLEQRLATGITPQLVRLSVGIE-DVEDLIADLQQALAE 381
Cdd:PLN02242 348 NSTQFGFmAVSLGYYETLMSCSGSSTSSELDPEEKAAAGISPGLVRMSVGYTgTLEQRWSQFEKALSA 415
|
|
| PRK07050 |
PRK07050 |
cystathionine beta-lyase; Provisional |
37-380 |
2.88e-64 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 180810 [Multi-domain] Cd Length: 394 Bit Score: 209.97 E-value: 2.88e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 37 GEHTGYEYSRSANPTRTALESAIAELEGGSRGYAFASGLAACSTV-LELLDKDSHLIAVDDLYGGTYRLLEKVrSRTAGL 115
Cdd:PRK07050 52 RQDVQWRYGLHATPTSLALAQRLAEIEGGRHALLQPSGLAAISLVyFGLVKAGDDVLIPDNAYGPNRDHGEWL-ARDFGI 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 116 RVTYVAPADLAGLEQAIEPDTKMIWVETPTNPLLKLADLSAIAAIAKKHQLISVADNTFASPYLQRPLDLGFDVVVHSAT 195
Cdd:PRK07050 131 TVRFYDPLIGAGIADLIQPNTRLIWLEAPGSVTMEVPDVPAITAAARARGVVTAIDNTYSAGLAFKPFEHGVDISVQALT 210
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 196 KYLNGHSDVVAGVAAVGDNpALAEQLGFLQNAVGGILDPFSSFLTLRGVRTLALRMQRHSDSALRIAQWLESQPQVENVY 275
Cdd:PRK07050 211 KYQSGGSDVLMGATITADA-ELHAKLKLARMRLGIGVSADDCSLVLRGLPSLQVRLAAHDRSALEVAEWLKARPEIATVL 289
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 276 YPGLPSHPQHELAARQMTRFGGMISVRLkgDDAYARRVIQRS----RLFTLAESLGGVESLiSQPF---SMTHASIPLEQ 348
Cdd:PRK07050 290 HPALPDCPGHAFWMRDFTGAGGLFSVVF--DERYSPAQVDAFvealELFAIGWSWGGACSL-AMPYdvaSMRTAKWPHRG 366
|
330 340 350
....*....|....*....|....*....|..
gi 505190166 349 RlatgitpqLVRLSVGIEDVEDLIADLQQALA 380
Cdd:PRK07050 367 T--------LVRLYIGLEDEADLIADLEQALE 390
|
|
| PRK08114 |
PRK08114 |
cystathionine beta-lyase; Provisional |
3-380 |
3.52e-64 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 181231 [Multi-domain] Cd Length: 395 Bit Score: 209.94 E-value: 3.52e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 3 KFDTLTVHAGYTPDAT-GAVMPAIYATSTY------------AQPAPGEhtgYEYSRSANPTRTALESAIAELEGGSRGY 69
Cdd:PRK08114 5 KLDTQLVNAGRSKKYTqGSVNSVIQRASSLvfdsveakkhatRNRANGE---LFYGRRGTLTHFSLQEAMCELEGGAGCA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 70 AFASGLAACS-TVLELLDKDSHLIAVDDLYGGTYRLLEKVRSRTaGLRVTYVAPADLAGLEQAIEPDTKMIWVETPTNPL 148
Cdd:PRK08114 82 LYPCGAAAVAnAILAFVEQGDHVLMTGTAYEPTQDFCSKILSKL-GVTTTWFDPLIGADIAKLIQPNTKVVFLESPGSIT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 149 LKLADLSAI--AAIAKKHQLISVADNTFASPYLQRPLDLGFDVVVHSATKYLNGHSDVVAGVAAVgdNPALAEQLGFLQN 226
Cdd:PRK08114 161 MEVHDVPAIvaAVRSVNPDAVIMIDNTWAAGVLFKALDFGIDISIQAGTKYLVGHSDAMIGTAVA--NARCWEQLRENSY 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 227 AVGGILDPFSSFLTLRGVRTLALRMQRHSDSALRIAQWLESQPQVENVYYPGLPSHPQHELAARQMTRFGGMISVRLKG- 305
Cdd:PRK08114 239 LMGQMVDADTAYMTSRGLRTLGVRLRQHEESSLKVAEWLAEHPEVARVNHPALPGCKGHEFWKRDFTGSSGLFSFVLKKk 318
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 505190166 306 -DDAYARRVIQRSRLFTLAESLGGVESLI--SQPFSMthASI-PLEQRLATGitpQLVRLSVGIEDVEDLIADLQQALA 380
Cdd:PRK08114 319 lTDEQLANYLDNFSLFSMAYSWGGFESLIlaNQPEEI--AAIrPAGEVDFTG---TLIRLHIGLEDVDDLIADLAAGFA 392
|
|
| PRK06702 |
PRK06702 |
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase; |
6-379 |
1.65e-62 |
|
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase;
Pssm-ID: 102505 [Multi-domain] Cd Length: 432 Bit Score: 206.44 E-value: 1.65e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 6 TLTVHAGYTPDATGAVMPAIYATSTYAQPAPG--------EHTGYEYSRSANPTRTALESAIAELEGGSRGYAFASGLAA 77
Cdd:PRK06702 9 TICVQGGYTPKNGEPRVLPLYQSTTYKYDTSDdlaalfnlEAEGYIYTRIGNPTLAAFEQKLAELEGGVGAVATASGQAA 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 78 CS-TVLELLDKDSHLIAVDDLYGGTYRLLeKVRSRTAGLRVTYVAPADLAGLEQAIEPD-TKMIWVETPTNPLLKLADLS 155
Cdd:PRK06702 89 IMlAVLNICSSGDHLLCSSTVYGGTFNLF-GVSLRKLGIDVTFFNPNLTADEIVALANDkTKLVYAESLGNPAMNVLNFK 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 156 AIAAIAKKHQLISVADNTFASPYLQRPLDLGFDVVVHSATKYLNGHSDVVAGVAAVGDN--------PALAEQ------L 221
Cdd:PRK06702 168 EFSDAAKELEVPFIVDNTLATPYLCQAFEHGANIIVHSTTKYIDGHASSLGGIVIDGGNfdwtngkyPELVEPdpsyhgV 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 222 GFLQN----------------AVGGILDPFSSFLTLRGVRTLALRMQRHSDSALRIAQWLESQPQVENVYYPGLPSHPQH 285
Cdd:PRK06702 248 SYVQNfgaaayivkarvqllrDYGNCMSPFNAYISNIGLETLHLRMERHSENALAVAKWLADHERIEWVNYPGLDSNENY 327
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 286 ELAARQMTR-FGGMISVRLKGDDAYARRVIQRSRLFTLAESLGGVESLISQPFSMTHASIPLEQRLATGITPQLVRLSVG 364
Cdd:PRK06702 328 SLAQKYLKKgASGVLTFGIKGGLEAAKEFIANVKLATLVTHVADARTCVIHPASTTHRQLSAEDQRLAGVTSDLIRLSVG 407
|
410
....*....|....*
gi 505190166 365 IEDVEDLIADLQQAL 379
Cdd:PRK06702 408 IEDVSDIIADLEAAL 422
|
|
| AAT_I |
cd01494 |
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP) ... |
52-200 |
7.10e-11 |
|
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. Structure and sequence analysis has revealed that the PLP dependent enzymes can be classified into four major groups of different evolutionary origin: aspartate aminotransferase superfamily (fold type I), tryptophan synthase beta superfamily (fold type II), alanine racemase superfamily (fold type III), and D-amino acid superfamily (fold type IV) and Glycogen phophorylase family (fold type V).
Pssm-ID: 99742 [Multi-domain] Cd Length: 170 Bit Score: 60.47 E-value: 7.10e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 52 RTALESAIAELEGGSRGYAFA--SGLAACSTVLE-LLDKDSHLIAVDDLYGGTYRllekVRSRTAGLRVTYVA--PADLA 126
Cdd:cd01494 2 LEELEEKLARLLQPGNDKAVFvpSGTGANEAALLaLLGPGDEVIVDANGHGSRYW----VAAELAGAKPVPVPvdDAGYG 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 127 GLEQAIEPD------TKMIWVETPTNPLLKLADLSAIAAIAKKHQLISVADNTFASPY----LQRPLDLGFDVVVHSATK 196
Cdd:cd01494 78 GLDVAILEElkakpnVALIVITPNTTSGGVLVPLKEIRKIAKEYGILLLVDAASAGGAspapGVLIPEGGADVVTFSLHK 157
|
....
gi 505190166 197 YLNG 200
Cdd:cd01494 158 NLGG 161
|
|
| AspB |
COG0436 |
Aspartate/methionine/tyrosine aminotransferase [Amino acid transport and metabolism]; ... |
124-214 |
8.81e-08 |
|
Aspartate/methionine/tyrosine aminotransferase [Amino acid transport and metabolism]; Aspartate/methionine/tyrosine aminotransferase is part of the Pathway/BioSystem: Isoleucine, leucine, valine biosynthesis
Pssm-ID: 440205 [Multi-domain] Cd Length: 387 Bit Score: 53.60 E-value: 8.81e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 124 DLAGLEQAIEPDTKMIWVETPTNP---LLKLADLSAIAAIAKKHQLISVADNTFAspylqrplDLGFD------------ 188
Cdd:COG0436 152 DPEALEAAITPRTKAIVLNSPNNPtgaVYSREELEALAELAREHDLLVISDEIYE--------ELVYDgaehvsilslpg 223
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 505190166 189 -----VVVHSATKYLN----------GHSDVVAGVAAVGDN 214
Cdd:COG0436 224 lkdrtIVINSFSKSYAmtgwrigyavGPPELIAALLKLQSN 264
|
|
| AAT_like |
cd00609 |
Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent ... |
111-221 |
7.52e-07 |
|
Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. The major groups in this CD corresponds to Aspartate aminotransferase a, b and c, Tyrosine, Alanine, Aromatic-amino-acid, Glutamine phenylpyruvate, 1-Aminocyclopropane-1-carboxylate synthase, Histidinol-phosphate, gene products of malY and cobC, Valine-pyruvate aminotransferase and Rhizopine catabolism regulatory protein.
Pssm-ID: 99734 [Multi-domain] Cd Length: 350 Bit Score: 50.42 E-value: 7.52e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 111 RTAGLRVTYVA-------PADLAGLEQAIEPDTKMIWVETPTNP---LLKLADLSAIAAIAKKHQLISVADNTFA----- 175
Cdd:cd00609 101 RLAGAEVVPVPldeeggfLLDLELLEAAKTPKTKLLYLNNPNNPtgaVLSEEELEELAELAKKHGILIISDEAYAelvyd 180
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 505190166 176 -SPYLQRPLDLGFD--VVVHSATKYLNghsdvVAGV---AAVGDNPALAEQL 221
Cdd:cd00609 181 gEPPPALALLDAYErvIVLRSFSKTFG-----LPGLrigYLIAPPEELLERL 227
|
|
| Aminotran_1_2 |
pfam00155 |
Aminotransferase class I and II; |
54-296 |
5.45e-06 |
|
Aminotransferase class I and II;
Pssm-ID: 395103 [Multi-domain] Cd Length: 351 Bit Score: 47.69 E-value: 5.45e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 54 ALESAIAELEGGSRGYA--------FASGLAACSTVLELLDKDSH-LIAVDDLYGGTYRllEKVRSRTAGLR-VTYVAPA 123
Cdd:pfam00155 43 ELREALAKFLGRSPVLKldreaavvFGSGAGANIEALIFLLANPGdAILVPAPTYASYI--RIARLAGGEVVrYPLYDSN 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 124 ----DLAGLEQAIEPDTKMIWVETPTNP---LLKLADLSAIAAIAKKHQLISVADNTFA-------SPYLQRPL--DLGF 187
Cdd:pfam00155 121 dfhlDFDALEAALKEKPKVVLHTSPHNPtgtVATLEELEKLLDLAKEHNILLLVDEAYAgfvfgspDAVATRALlaEGPN 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 188 DVVVHSATK----------YLNGHSDVVAGVAAVGDNPALAEQlgfLQNAVGGILDPfsSFLTLRGVRTLALRMQRHSD- 256
Cdd:pfam00155 201 LLVVGSFSKafglagwrvgYILGNAAVISQLRKLARPFYSSTH---LQAAAAAALSD--PLLVASELEEMRQRIKERRDy 275
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 505190166 257 --SALRIAQWLESQPQVENVYYPGLPSHPQHELAARQMTRFG 296
Cdd:pfam00155 276 lrDGLQAAGLSVLPSQAGFFLLTGLDPETAKELAQVLLEEVG 317
|
|
| PRK06108 |
PRK06108 |
pyridoxal phosphate-dependent aminotransferase; |
111-171 |
1.05e-05 |
|
pyridoxal phosphate-dependent aminotransferase;
Pssm-ID: 180404 Cd Length: 382 Bit Score: 47.25 E-value: 1.05e-05
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 505190166 111 RTAGLRVTYVAPA--------DLAGLEQAIEPDTKMIWVETPTNPL---LKLADLSAIAAIAKKHQLISVAD 171
Cdd:PRK06108 126 KILGARVVCVPLDfggggwtlDLDRLLAAITPRTRALFINSPNNPTgwtASRDDLRAILAHCRRHGLWIVAD 197
|
|
| PRK07682 |
PRK07682 |
aminotransferase; |
120-175 |
1.74e-05 |
|
aminotransferase;
Pssm-ID: 181082 [Multi-domain] Cd Length: 378 Bit Score: 46.27 E-value: 1.74e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*....
gi 505190166 120 VAPADLaglEQAIEPDTKMIWVETPTNP---LLKLADLSAIAAIAKKHQLISVADNTFA 175
Cdd:PRK07682 142 VQPAQI---EAAITAKTKAILLCSPNNPtgaVLNKSELEEIAVIVEKHDLIVLSDEIYA 197
|
|
| PRK05764 |
PRK05764 |
aspartate aminotransferase; Provisional |
128-171 |
8.77e-05 |
|
aspartate aminotransferase; Provisional
Pssm-ID: 235596 Cd Length: 393 Bit Score: 44.35 E-value: 8.77e-05
10 20 30 40
....*....|....*....|....*....|....*....|....*..
gi 505190166 128 LEQAIEPDTKMIWVETPTNP---LLKLADLSAIAAIAKKHQLISVAD 171
Cdd:PRK05764 157 LEAAITPKTKALILNSPSNPtgaVYSPEELEAIADVAVEHDIWVLSD 203
|
|
| TA_like |
cd06502 |
Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP) ... |
17-269 |
1.20e-04 |
|
Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a secondary glycine biosynthetic pathway.
Pssm-ID: 99748 [Multi-domain] Cd Length: 338 Bit Score: 43.48 E-value: 1.20e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 17 ATGAVMPAIYAtstyaqpAPGEHTGYEysrsANPTRTALESAIAELEGGSRGYAFASGLAACSTVLE---------LLDK 87
Cdd:cd06502 10 PTPEMLEAMAA-------ANVGDDVYG----EDPTTAKLEARAAELFGKEAALFVPSGTAANQLALAahtqpggsvICHE 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 88 DSHLIavDDLYGGTyrllekvrSRTAGLRVTYVAPAD----LAGLEQAIEPD-------TKMIWVETPTN--PLLKLADL 154
Cdd:cd06502 79 TAHIY--TDEAGAP--------EFLSGVKLLPVPGENgkltPEDLEAAIRPRddihfppPSLVSLENTTEggTVYPLDEL 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 155 SAIAAIAKKHQL-----------ISVADNTFASPYLQrpldlGFDVVVHSATKylnghsdvvAGVAAVGD----NPALAE 219
Cdd:cd06502 149 KAISALAKENGLplhldgarlanAAAALGVALKTYKS-----GVDSVSFCLSK---------GGGAPVGAvvvgNRDFIA 214
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 505190166 220 QLGFLQNAVGGILDPfSSFLTLRGVRTLA----LRMQRHS-DSALRIAQWLESQP 269
Cdd:cd06502 215 RARRRRKQAGGGMRQ-SGFLAAAGLAALEndlwLRRLRHDhEMARRLAEALEELG 268
|
|
| PRK07777 |
PRK07777 |
putative succinyldiaminopimelate transaminase DapC; |
124-171 |
1.20e-04 |
|
putative succinyldiaminopimelate transaminase DapC;
Pssm-ID: 236095 [Multi-domain] Cd Length: 387 Bit Score: 43.87 E-value: 1.20e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 505190166 124 DLAGLEQAIEPDTKMIWVETPTNP---LLKLADLSAIAAIAKKHQLISVAD 171
Cdd:PRK07777 148 DLDALRAAVTPRTRALIVNSPHNPtgtVLTAAELAAIAELAVEHDLLVITD 198
|
|
| PRK00451 |
PRK00451 |
aminomethyl-transferring glycine dehydrogenase subunit GcvPA; |
111-191 |
1.58e-04 |
|
aminomethyl-transferring glycine dehydrogenase subunit GcvPA;
Pssm-ID: 234769 [Multi-domain] Cd Length: 447 Bit Score: 43.59 E-value: 1.58e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 111 RTAGLRVTYVAPA----DLAGLEQAIEPDTKMIWVETPtNPLLKLADLSAIAAIAKKHQLISVAdntFASP----YLQRP 182
Cdd:PRK00451 176 KGQGIEVVEVPYEdgvtDLEALEAAVDDDTAAVVVQYP-NFFGVIEDLEEIAEIAHAGGALFIV---GVDPvslgLLKPP 251
|
....*....
gi 505190166 183 LDLGFDVVV 191
Cdd:PRK00451 252 GEYGADIVV 260
|
|
| GDC-P |
cd00613 |
Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine ... |
92-202 |
3.47e-03 |
|
Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1.2.10 (GDC) also annotated as glycine cleavage system or glycine synthase. GDC consists of four proteins P, H, L and T. The reaction catalysed by this protein is: Glycine + lipoylprotein <=> S-aminomethyldihydrolipoylprotein + CO2. Alpha-beta-type dimers associate to form an alpha(2)beta(2) tetramer, where the alpha- and beta-subunits are structurally similar and appear to have arisen by gene duplication and subsequent divergence with a loss of one active site. The members of this CD are widely dispersed among all three forms of cellular life.
Pssm-ID: 99737 [Multi-domain] Cd Length: 398 Bit Score: 39.14 E-value: 3.47e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 92 IAVDDLYGGTYRLLEKVRSRTAGLRVTYVAPA-----DLAGLEQAIEPDTKMIWVETP-TNPLLkLADLSAIAAIAKKH- 164
Cdd:cd00613 111 VLVPDSAHPTNPAVARTRGEPLGIEVVEVPSDeggtvDLEALKEEVSEEVAALMVQYPnTLGVF-EDLIKEIADIAHSAg 189
|
90 100 110
....*....|....*....|....*....|....*....
gi 505190166 165 -QLISVADNTFASpYLQRPLDLGFDVVVhsatkyLNGHS 202
Cdd:cd00613 190 aLVYVDGDNLNLT-GLKPPGEYGADIVV------GNLQK 221
|
|
| PRK09276 |
PRK09276 |
LL-diaminopimelate aminotransferase; Provisional |
124-214 |
6.53e-03 |
|
LL-diaminopimelate aminotransferase; Provisional
Pssm-ID: 181749 Cd Length: 385 Bit Score: 38.35 E-value: 6.53e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505190166 124 DLAGLEQAIEPDTKMIWVETPTNPLLKLADLS---AIAAIAKKHQLISVADNTFASPYL--QRPL-----DLGFDVVV-- 191
Cdd:PRK09276 155 DLDAIPEDVAKKAKLMFINYPNNPTGAVADLEffeEVVDFAKKYDIIVCHDAAYSEIAYdgYKPPsflevPGAKDVGIef 234
|
90 100 110
....*....|....*....|....*....|...
gi 505190166 192 HSATKYLN----------GHSDVVAGVAAVGDN 214
Cdd:PRK09276 235 HSLSKTYNmtgwrigfavGNADLIAGLGKVKSN 267
|
|
| |
