|
Name |
Accession |
Description |
Interval |
E-value |
| PRK10600 |
PRK10600 |
nitrate/nitrite two-component system sensor histidine kinase NarX; |
29-591 |
0e+00 |
|
nitrate/nitrite two-component system sensor histidine kinase NarX;
Pssm-ID: 182581 [Multi-domain] Cd Length: 569 Bit Score: 876.69 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505191104 29 MGISAWMSQSIQGNAHAINKAGSLRMQSYRLLAQVPLDERHEALIRELERDENSPDLQRSVEQEGLTQPFDTLRDYWQQT 108
Cdd:PRK10600 1 MAVSGWLVQGVQGSAHAINKAGSLRMQSYRLLAAVPLSEKDKPLLKEMEQTAFSPELQRAAERDGQLAQLQALQDYWRNE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505191104 109 LQPRLRSAQRPADAAPQVAHFVQLLDKLVSDIDRQTERRLLMVTLVQAGFIALTLLLLIGTTCYLRRRLLHPWRQLVEMA 188
Cdd:PRK10600 81 LKPALQQAQNPEDVAADVAQFVAGLDALVSAFDHTTEMRIETVVLVHRVFAVFMALLLVFTIIWLRRRLLQPWRQLLSMA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505191104 189 LAVGRGDFSRRFAQRGHqDEMASLGGALNTMSDELSATYSGLEQRVAEKTADLQQKNQMLSFLYRASRLLHASEPLCSRL 268
Cdd:PRK10600 161 NAVSHRDFTQRANISGR-DEMAMLGTALNNMSAELAESYAVLEQRVQEKTAGLEQKNQILSFLWQANRRLHSRAPLCERL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505191104 269 TPLLNQLQILTPLRAIQVRLYENDSREPLLQLSGNQPLrpeHCHNPVCSACLHDSDRQHPDNPSLSWSLSDKLGDYGVIV 348
Cdd:PRK10600 240 SPVLNGLQNLTLLRDIELRVYETDDEENHQEFTCQSDM---TCDDKGCQLCPRGVLPVGDRGTTLKWRLSDKHGQYGILL 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505191104 349 AQHAPQQPLNDEHRQLVNTLVEQLTSVLAIERQVDHQQQLMLMEERAAIARELHDSIAQSLSCLKMQIACLQMQGETLSS 428
Cdd:PRK10600 317 ATLPQGRHLSHDQQQLVDTLVEQLTATLALERQQERQQQLIVMEERATIARELHDSIAQSLSCMKMQVSCLQMQGDALPE 396
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505191104 429 ASQALVQQMREELNGAYRQLRELLTTFRLQLTEPGLLAALQSTVAEFNPKLGLNISLDYQLGPRTVPAYQAIHLLQIARE 508
Cdd:PRK10600 397 SSRELLSQIRNELNASWRQLRELLTTFRLQLTEPGLRPALEASCEEFSARFGFPVKLDYQLPPRLVPSHQAIHLLQIARE 476
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505191104 509 ALSNILKHAAASEVSIQVINKRGEVTLSVCDNGRGLPAETSRPDHYGLIIMRDRAKSLHGRCDILPRSGGGTEVRVSFTP 588
Cdd:PRK10600 477 ALSNALKHAQASEVVVTVAQNQNQVKLSVQDNGCGVPENAERSNHYGLIIMRDRAQSLRGDCRVRRRESGGTEVVVTFIP 556
|
...
gi 505191104 589 DNH 591
Cdd:PRK10600 557 EKT 559
|
|
| PRK10935 |
PRK10935 |
nitrate/nitrite two-component system sensor histidine kinase NarQ; |
9-588 |
3.52e-111 |
|
nitrate/nitrite two-component system sensor histidine kinase NarQ;
Pssm-ID: 236800 [Multi-domain] Cd Length: 565 Bit Score: 343.76 E-value: 3.52e-111
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505191104 9 SIVNQVALLMLLSGILGVAGMGIsawMSQSIqGNAHAINKAGSLRMQSYRLL--AQVPLDErHEALIRELERDENSPDLQ 86
Cdd:PRK10935 10 SIARAMLLIILLSSLTTGFALLT---LASSL-RDAEAINIAGSLRMQSYRLAydLQSGSPQ-LNAHLREFEQSLHSPALK 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505191104 87 RS----VEQEgLTQPFDTLRDYWQqTLQPRLRSAQRPADAApQVAHFVQLLDKLVSDIDRQTERRLLMVTLVQ-AGFIAL 161
Cdd:PRK10935 85 NLnrwyVPED-VKDRYALLIARWL-EMKSYLEQGDSRWYQA-NIANYVDQIDLFVLALQHFAERKLILLAAISlLGLILI 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505191104 162 TLLLLIGTTcYLRRRLLHPWRQLVEMALAVGRGDFSRRFAQRGHQDEMASLGGALNTMSDELSATYSGLEQRVAEKTADL 241
Cdd:PRK10935 162 LTLVFFTVR-FTRRQVVAPLNQLVTASQQIEKGQFDHIPLDTTLPNELGLLAKAFNQMSSELHKLYRSLEASVEEKTRKL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505191104 242 QQKNQMLSFLYRASRLLHASEPLCSRLTPLLNQLQILTPLRAIQVRLYENdsrePLLQLSGNQPlrpehchnpvcsaclh 321
Cdd:PRK10935 241 TQANRSLEVLYQCSQALNASQIDVHCFRHILQIVRDHEGLDYLELEVGEN----EHWRISEGQP---------------- 300
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505191104 322 dsdrqhpdNPSLSWSLSD-KLGD--YGVIVAQHAPQQPlndeHRQLVNTLVEQLTSVLAIERQVDHQQQLMLMEERAAIA 398
Cdd:PRK10935 301 --------NPELPWQILPlTMEDtvLGYLHWQASLPCP----DEPLMNNVAQMLGRGLYFNQAQKQQQQLLLMEERATIA 368
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505191104 399 RELHDSIAQSLSCLKMQIACLQMQGETLSSASQALVQQMREELNGAYRQLRELLTTFRLQLTEPGLLAALQSTVAEFNPK 478
Cdd:PRK10935 369 RELHDSLAQVLSYLKIQLTLLKRSLDEDNAKAQSIIAEFDQALSDAYRQLRELLTTFRLTIQEANLGSALEEMLDQLRNQ 448
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505191104 479 LGLNISLDYQLGPRTVPAYQAIHLLQIAREALSNILKHAAASEVSIQ-VINKRGEVTLSVCDNGRGLPAETSRPDHYGLI 557
Cdd:PRK10935 449 TDAKITLDCRLPSQALDAQQQVHLLQIIREATLNAIKHANASEIAVScVTNPDGEHTVSIRDDGIGIGELKEPEGHYGLN 528
|
570 580 590
....*....|....*....|....*....|.
gi 505191104 558 IMRDRAKSLHGRCDILPRSGGGTEVRVSFTP 588
Cdd:PRK10935 529 IMQERAERLGGTLTISQPPGGGTTVSLTFPS 559
|
|
| NarX_sensor |
cd22900 |
ligand binding sensor domain of NarX, and related chemoreceptors; The periplasmic ligand ... |
37-152 |
7.27e-53 |
|
ligand binding sensor domain of NarX, and related chemoreceptors; The periplasmic ligand binding sensor domain of NarX is a histidine kinase receptor that responds to nitrate and nitrite to effect regulation of anaerobic respiration in various bacteria and similar proteins. It forms a homodimer and binds to ligands such as nitrate via the dimerization interface, a feature that appears to be conserved in this domain superfamily. NarX-NarL sensor-response regulator pair controls Escherichia coli gene expression in response to nitrate and nitrite. NarX has been shown to exhibit a clear kinetic preference for NarL over NarP, the sensor response partner of NarQ.
Pssm-ID: 438632 [Multi-domain] Cd Length: 116 Bit Score: 176.21 E-value: 7.27e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505191104 37 QSIQGNAHAINKAGSLRMQSYRLLAQVPLDERHEALIRELERDENSPDLQRSVEQEGLTQPFDTLRDYWQQTLQPRLRSA 116
Cdd:cd22900 1 NSIQGNAHAINKAGSLRMQSYRLLAAVPLNPQDQALLDELEQTLSSPELQRAARREGLQSQLQALQQYWQQQLKPALLAA 80
|
90 100 110
....*....|....*....|....*....|....*.
gi 505191104 117 QRPADAAPQVAHFVQLLDKLVSDIDRQTERRLLMVT 152
Cdd:cd22900 81 KNPEDARAEVAAFVAQLDQLVSQIDQKTEQRLSLIS 116
|
|
| ComP |
COG4585 |
Signal transduction histidine kinase ComP [Signal transduction mechanisms]; |
364-586 |
1.86e-52 |
|
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
Pssm-ID: 443642 [Multi-domain] Cd Length: 252 Bit Score: 180.20 E-value: 1.86e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505191104 364 LVNTLVEQLTSVLAIERQVDHQQQLMLMEERAAIARELHDSIAQSLSCLKMQIACLQMQGETLSSASQALVQQMREELNG 443
Cdd:COG4585 24 LVLLRARRAERAAELERELAARAEEAREEERRRIARELHDGVGQSLSAIKLQLEAARRLLDADPEAAREELEEIRELARE 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505191104 444 AYRQLRELLTTFR-LQLTEPGLLAALQSTVAEFNPKLGLNISLDYQLGPRTVPAYQAIHLLQIAREALSNILKHAAASEV 522
Cdd:COG4585 104 ALAELRRLVRGLRpPALDDLGLAAALEELAERLLRAAGIRVELDVDGDPDRLPPEVELALYRIVQEALTNALKHAGATRV 183
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 505191104 523 SIQVINKRGEVTLSVCDNGRGLPAETSRPDHYGLIIMRDRAKSLHGRCDILPRSGGGTEVRVSF 586
Cdd:COG4585 184 TVTLEVDDGELTLTVRDDGVGFDPEAAPGGGLGLRGMRERAEALGGTLTIGSAPGGGTRVRATL 247
|
|
| HATPase_UhpB-NarQ-NarX-like |
cd16917 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
502-586 |
9.94e-27 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains.
Pssm-ID: 340394 [Multi-domain] Cd Length: 87 Bit Score: 103.79 E-value: 9.94e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505191104 502 LLQIAREALSNILKHAAASEVSIQVINKRGEVTLSVCDNGRGLPAETSRPD-HYGLIIMRDRAKSLHGRCDILPRSGGGT 580
Cdd:cd16917 1 LYRIVQEALTNALKHAGASRVRVTLSYTADELTLTVVDDGVGFDGPAPPGGgGFGLLGMRERAELLGGTLTIGSRPGGGT 80
|
....*.
gi 505191104 581 EVRVSF 586
Cdd:cd16917 81 RVTARL 86
|
|
| NarX_NarQ_sensor |
cd19408 |
ligand binding sensor domain of NarX and NarQ, and related chemoreceptors; The periplasmic ... |
37-150 |
8.67e-26 |
|
ligand binding sensor domain of NarX and NarQ, and related chemoreceptors; The periplasmic ligand binding sensor domain of NarX and NarQ is a histidine kinase receptor that responds to nitrate and nitrite to effect regulation of anaerobic respiration in various bacteria and similar proteins. It forms a homodimer and binds to ligands such as nitrate via the dimerization interface, a feature that appears to be conserved in this domain superfamily. NarX-NarL sensor-response regulator pair, along with NarQ-NarP, control Escherichia coli gene expression in response to nitrate and nitrite. NarX has been shown to exhibit a clear kinetic preference for NarL over NarP, whereas NarQ exhibits a relatively slight kinetic preference for NarL. There is asymmetry in the Nar cross-regulation network with NarQ shown to interact similarly with both response regulators, while NarX interacts preferentially with NarL.
Pssm-ID: 438626 [Multi-domain] Cd Length: 126 Bit Score: 102.32 E-value: 8.67e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505191104 37 QSIQGNAHAINKAGSLRMQSYRLLAQVPLDERH-----EALIRELERDENSPDLQRSVEQEG---LTQPFDTLRDYWQQT 108
Cdd:cd19408 1 ESTEGDAAAINLAGSLRMQSYRLASLLLQAALEpaeqlAQLIDEFEQRLNSPALTRALPRDSdhpLRQAYQAVLQHWQQE 80
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 505191104 109 LQPRL----RSAQRPADAAPQVAHFVQLLDKLVSDIDRQTERRLLM 150
Cdd:cd19408 81 LRPALeaaaSGAADREAYLAEVDEFVAQIDQLVKLLQQDTEAKIRL 126
|
|
| UhpB |
COG3851 |
Signal transduction histidine kinase UhpB, glucose-6-phosphate specific [Signal transduction ... |
355-587 |
1.57e-25 |
|
Signal transduction histidine kinase UhpB, glucose-6-phosphate specific [Signal transduction mechanisms];
Pssm-ID: 443060 [Multi-domain] Cd Length: 493 Bit Score: 110.10 E-value: 1.57e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505191104 355 QPLNDEHRQLVNTLVEQLtsVLAierqvdhqQQLMLMEE--RAAIARELHDSIAQSLSCLKMQIACLQMQGETLSSASQA 432
Cdd:COG3851 262 QRQRQLNQQLEQELRENR--ALA--------RQLVSAEEseRREIARELHDEIGQNITAIRTQASILKRLAPQPEIEQSA 331
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505191104 433 lvQQMREELNGAYRQLRELLTTFR-LQLTEPGLLAALQSTVAEF-NPKLGLNISLDYQLGPRTVPAYQAIHLLQIAREAL 510
Cdd:COG3851 332 --QSIESLALRIYDTTRRLLDRLRpAVLDELGLEEALRELPRELaFEEPGISCQLDLRGDPSLLDDTLQLTLYRLVQEAL 409
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 505191104 511 SNILKHAAASEVSIQVINKRGEVTLSVCDNGRGLPAETSRPdHYGLIIMRDRAKSLHGRCDILPRsGGGTEVRVSFT 587
Cdd:COG3851 410 TNILKHAEASQIRISLSQDKRLLSLEIRDDGIGLPPELRAK-GFGLRGMRERVRALGGDFRLSSA-PKGTRLSVLLP 484
|
|
| PRK11644 |
PRK11644 |
signal transduction histidine-protein kinase/phosphatase UhpB; |
355-585 |
1.45e-19 |
|
signal transduction histidine-protein kinase/phosphatase UhpB;
Pssm-ID: 236945 [Multi-domain] Cd Length: 495 Bit Score: 91.96 E-value: 1.45e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505191104 355 QPLNDE-HRQLVNTLVEQLTSVL---AIERQVDHQQQLML--------------MEE--RAAIARELHDSIAQSLSCLKM 414
Cdd:PRK11644 243 QTWHDHpVDLLLSLLAQSLTGLLlgaGIQRQRELNQSLQKelarnrhlaerlleTEEsvRRDVARELHDEIGQTITAIRT 322
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505191104 415 QIACLQmqgeTLSSASQALVQ--QMREELN-GAYRQLRELLTTFR-LQLTEPGLLAALQSTVAEFNPK-LGLNISLDYQL 489
Cdd:PRK11644 323 QAGIIK----RLAADNASVKQsaQLIEQLSlGVYDTVRRLLGRLRpRQLDDLTLEQAIRSLMREMELEdRGIVSHLDWRI 398
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505191104 490 GPRTVPAYQAIHLLQIAREALSNILKHAAASEVSIQVINKRGEVTLSVCDNGRGLPAETSRPDhYGLIIMRDRAKSLHGR 569
Cdd:PRK11644 399 DESALSETQRVTLFRVCQEGLNNIVKHADASAVTLQGWQQDERLMLVIEDDGSGLPPGSGQQG-FGLRGMRERVTALGGT 477
|
250
....*....|....*.
gi 505191104 570 CDIlpRSGGGTEVRVS 585
Cdd:PRK11644 478 LTI--SCTHGTRLSVS 491
|
|
| NarQ_sensor |
cd22899 |
ligand binding sensor domain of NarQ, and related chemoreceptors; The periplasmic ligand ... |
40-150 |
1.02e-15 |
|
ligand binding sensor domain of NarQ, and related chemoreceptors; The periplasmic ligand binding sensor domain of NarQ is a histidine kinase receptor that responds to nitrate and nitrite to effect regulation of anaerobic respiration in various bacteria and similar proteins. It forms a homodimer and binds to ligands such as nitrate via the dimerization interface, a feature that appears to be conserved in this domain superfamily. NarQ-NarP sensor-response regulator pair controls Escherichia coli gene expression in response to nitrate and nitrite. NarQ has been shown to interact equally with NarP and NarL response regulators; NarL is the sensor response partner of NarX.
Pssm-ID: 438631 [Multi-domain] Cd Length: 116 Bit Score: 73.32 E-value: 1.02e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505191104 40 QGNAHAINKAGSLRMQSYRLL----AQVPLDERHealIRELERDENSPDLQRSVEQ---EGLTQPFDTLRDYWQQtLQPR 112
Cdd:cd22899 4 LSDAEAINVAGSLRMQSYRLAydleSESPLLEQH---IAQYEQSLHSPALQSLDRWyvpDEVKQRYQQLLARWQE-MKQY 79
|
90 100 110
....*....|....*....|....*....|....*...
gi 505191104 113 LRSaQRPADAAPQVAHFVQLLDKLVSDIDRQTERRLLM 150
Cdd:cd22899 80 LLQ-GDPASYLQQVASYVDQIDQFVLALQHFAERKLRL 116
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
499-586 |
2.06e-13 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 66.52 E-value: 2.06e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505191104 499 AIHLLQIAREALSNILKHA-AASEVSIQVINKRGEVTLSVCDNGRGLPAE----------TSRPDHY-------GLIIMR 560
Cdd:smart00387 3 PDRLRQVLSNLLDNAIKYTpEGGRITVTLERDGDHVEITVEDNGPGIPPEdlekifepffRTDKRSRkiggtglGLSIVK 82
|
90 100
....*....|....*....|....*.
gi 505191104 561 DRAKSLHGRCDILPRSGGGTEVRVSF 586
Cdd:smart00387 83 KLVELHGGEISVESEPGGGTTFTITL 108
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
499-586 |
2.66e-13 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 66.24 E-value: 2.66e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505191104 499 AIHLLQIAREALSNILKHAA-ASEVSIqVINKRGEVTLSVCDNGRGLPAET--------SRPDH-------YGLIIMRDR 562
Cdd:pfam02518 3 ELRLRQVLSNLLDNALKHAAkAGEITV-TLSEGGELTLTVEDNGIGIPPEDlprifepfSTADKrggggtgLGLSIVRKL 81
|
90 100
....*....|....*....|....
gi 505191104 563 AKSLHGRCDILPRSGGGTEVRVSF 586
Cdd:pfam02518 82 VELLGGTITVESEPGGGTTVTLTL 105
|
|
| HisKA_3 |
pfam07730 |
Histidine kinase; This is the dimerization and phosphoacceptor domain of a sub-family of ... |
393-456 |
5.35e-13 |
|
Histidine kinase; This is the dimerization and phosphoacceptor domain of a sub-family of histidine kinases. It shares sequence similarity with pfam00512 and pfam07536.
Pssm-ID: 429624 [Multi-domain] Cd Length: 68 Bit Score: 64.18 E-value: 5.35e-13
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 505191104 393 ERAAIARELHDSIAQSLSCLKMQIACLQMQGETLSSASQALVQQMREELNGAYRQLRELLTTFR 456
Cdd:pfam07730 1 ERNRIARELHDSVGQSLTAIKLQLELARRLLDRDPEEAREQLDAIRELAREALQELRRLLGDLR 64
|
|
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
172-586 |
7.68e-12 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 67.68 E-value: 7.68e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505191104 172 YLRRRLLHPWRQLVEMALAVGRGDFSRRFAQRGhQDEMASLGGALNTMSDELSATYSGLEQRVAEKTADLQQKNQMLSFL 251
Cdd:COG5000 28 LLARRLTRPLRRLAEATRAVAAGDLSVRLPVTG-DDEIGELARAFNRMTDQLKEQREELEERRRYLETILENLPAGVIVL 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505191104 252 YRASRLLHAseplcsrltpllnqlqiltplraiqvrlyeNDSREPLLQLSGNQPLrpehchnpvcsaclhdsdRQHPDNP 331
Cdd:COG5000 107 DADGRITLA------------------------------NPAAERLLGIPLEELI------------------GKPLEEL 138
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505191104 332 SLSWSLSDKLGDYGVIVAQHAPQQPLNDEHRQLVNTLVEQLTSVLAIERQVdhqQQLMLMEERAAI---AREL-HD---- 403
Cdd:COG5000 139 LPELDLAELLREALERGWQEEIELTRDGRRTLLVRASPLRDDGYVIVFDDI---TELLRAERLAAWgelARRIaHEiknp 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505191104 404 --SIAQSLSCLKMQIA-CLQMQGETLSSASQALVQQMREelngayrqLRELLTTFR-------LQLTEPGLLAALQSTVA 473
Cdd:COG5000 216 ltPIQLSAERLRRKLAdKLEEDREDLERALDTIIRQVDR--------LKRIVDEFLdfarlpePQLEPVDLNELLREVLA 287
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505191104 474 EFNPKL-GLNISLDYQLGPRTVPAY-------QAIH-LLQIAREALSNilkhaaASEVSIQVINKRGEVTLSVCDNGRGL 544
Cdd:COG5000 288 LYEPALkEKDIRLELDLDPDLPEVLadrdqleQVLInLLKNAIEAIEE------GGEIEVSTRREDGRVRIEVSDNGPGI 361
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*...
gi 505191104 545 PAE----------TSRPDHYGL---I---IMRDraksLHGRCDILPRSGGGTEVRVSF 586
Cdd:COG5000 362 PEEvlerifepffTTKPKGTGLglaIvkkIVEE----HGGTIELESRPGGGTTFTIRL 415
|
|
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
377-586 |
5.15e-10 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 59.92 E-value: 5.15e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505191104 377 AIERQVDHQQQLMLMEER--AAIARELHdsiaQSLSCLKMQIACLQMQGETLSSASQALVQQMREELNGAYRQLRELLT- 453
Cdd:COG2205 1 ELEEALEELEELERLKSEflANVSHELR----TPLTSILGAAELLLDEEDLSPEERRELLEIIRESAERLLRLIEDLLDl 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505191104 454 ------TFRLQLTEPGLLAALQSTVAEFNPKL-GLNISLDYQLGPRTVPAYQAIHLL-QIAREALSNILKHA-AASEVSI 524
Cdd:COG2205 77 srlesgKLSLELEPVDLAELLEEAVEELRPLAeEKGIRLELDLPPELPLVYADPELLeQVLANLLDNAIKYSpPGGTITI 156
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 505191104 525 QVINKRGEVTLSVCDNGRGLPAE-----------TSRPDHY-----GLIIMRDRAKSLHGRCDILPRSGGGTEVRVSF 586
Cdd:COG2205 157 SARREGDGVRISVSDNGPGIPEEeleriferfyrGDNSRGEggtglGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTL 234
|
|
| COG3920 |
COG3920 |
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ... |
379-592 |
6.08e-10 |
|
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];
Pssm-ID: 443125 [Multi-domain] Cd Length: 495 Bit Score: 61.84 E-value: 6.08e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505191104 379 ERQVDHQQQLMLMEERAAIARELHD------SIAQSLsclkmqiacLQMQGETLSSASqalVQQMREELNG-------AY 445
Cdd:COG3920 280 ERKRAEEELEASLEEKELLLRELHHrvknnlQVVSSL---------LRLQARRADDPE---AREALEESQNriqalalVH 347
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505191104 446 RQLRELLTTFRLQLTE--PGLLAALQSTVAEFNpklglnISLDYQLGPRTVPAYQAIHLLQIAREALSNILKHAAAS--- 520
Cdd:COG3920 348 ELLYQSEDWEGVDLRDylRELLEPLRDSYGGRG------IRIELDGPDVELPADAAVPLGLILNELVTNALKHAFLSgeg 421
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 505191104 521 -EVSIQVINKRGEVTLSVCDNGRGLPAETSRPDH--YGLIIMRDRAKSLHGRCDIlpRSGGGTEVRVSFTPDNHA 592
Cdd:COG3920 422 gRIRVSWRREDGRLRLTVSDNGVGLPEDVDPPARkgLGLRLIRALVRQLGGTLEL--DRPEGTRVRITFPLAELA 494
|
|
| HAMP |
smart00304 |
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; |
175-228 |
6.17e-08 |
|
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain;
Pssm-ID: 197640 [Multi-domain] Cd Length: 53 Bit Score: 49.17 E-value: 6.17e-08
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 505191104 175 RRLLHPWRQLVEMALAVGRGDFSRRFAQRGhQDEMASLGGALNTMSDELSATYS 228
Cdd:smart00304 1 RRLLRPLRRLAEAAQRIADGDLTVRLPVDG-RDEIGELARAFNEMADRLEETIA 53
|
|
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
419-586 |
7.35e-08 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 54.53 E-value: 7.35e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505191104 419 LQMQGETLSSASQALVQQMREELNGAYRQLRELLTTFRLQLTEPG-------LLAALQSTVAEFNPKL---GLNISLDYQ 488
Cdd:COG0642 132 LELLLEELDEEQREYLETILRSADRLLRLINDLLDLSRLEAGKLElepepvdLAELLEEVVELFRPLAeekGIELELDLP 211
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505191104 489 LGPRTVPAYqAIHLLQIAREALSNILKHAAA-SEVSIQVINKRGEVTLSVCDNGRGLPAE-----------TSRPDHY-- 554
Cdd:COG0642 212 DDLPTVRGD-PDRLRQVLLNLLSNAIKYTPEgGTVTVSVRREGDRVRISVEDTGPGIPPEdlerifepffrTDPSRRGgg 290
|
170 180 190
....*....|....*....|....*....|....*
gi 505191104 555 ---GLIIMRDRAKSLHGRCDILPRSGGGTEVRVSF 586
Cdd:COG0642 291 tglGLAIVKRIVELHGGTIEVESEPGKGTTFTVTL 325
|
|
| HAMP |
pfam00672 |
HAMP domain; |
173-225 |
7.77e-08 |
|
HAMP domain;
Pssm-ID: 459898 [Multi-domain] Cd Length: 53 Bit Score: 49.16 E-value: 7.77e-08
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 505191104 173 LRRRLLHPWRQLVEMALAVGRGDFSRRFAQRGhQDEMASLGGALNTMSDELSA 225
Cdd:pfam00672 2 LARRILRPLRRLAEAARRIASGDLDVRLPVSG-RDEIGELARAFNQMAERLRE 53
|
|
| PilJ |
pfam13675 |
Type IV pili methyl-accepting chemotaxis transducer N-term; This domain is found on many type ... |
34-127 |
1.69e-07 |
|
Type IV pili methyl-accepting chemotaxis transducer N-term; This domain is found on many type IV pili methyl-accepting chemotaxis transducer proteins where there is also a HAMP signature towards the C-terminus. It is a monomodular four-helix bundle and recognizes nitrate and nitrite (Matilla et al. FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 433397 [Multi-domain] Cd Length: 112 Bit Score: 49.78 E-value: 1.69e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505191104 34 WMSQSIQGNAHAINKAGSLRMQSYRLLAQVPLderheALIRELERDENSPDLQRSVEQ---------------------E 92
Cdd:pfam13675 1 WTLWQSEGDAAAINAAGSLRMQSQRLAKSVLL-----ALAGNYDLAEAFADLEESIDQfdrtlaalalgdlarglfvpaG 75
|
90 100 110
....*....|....*....|....*....|....*
gi 505191104 93 GLTQPFDTLRDYWQQTLQPRLRSAQRPADAAPQVA 127
Cdd:pfam13675 76 AIRAQLEAVQPLWERLRKPAEAVLAQQDTLAYLAA 110
|
|
| HAMP |
cd06225 |
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; ... |
178-223 |
4.92e-07 |
|
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The structure of the Af1503 HAMP dimer from Archaeoglobus fulgidus has been solved using nuclear magnetic resonance, revealing a parallel four-helix bundle; this structure has been confirmed by cross-linking analysis of HAMP domains from the Escherichia coli aerotaxis receptor Aer. It has been suggested that the four-helix arrangement can rotate between the unusually packed conformation observed in the NMR structure and a canonical coiled-coil arrangement. Such rotation may coincide with signal transduction, but a common mechanism by which HAMP domains relay a variety of input signals has yet to be established.
Pssm-ID: 381743 [Multi-domain] Cd Length: 45 Bit Score: 46.28 E-value: 4.92e-07
10 20 30 40
....*....|....*....|....*....|....*....|....*.
gi 505191104 178 LHPWRQLVEMALAVGRGDFSRRFAQRGHqDEMASLGGALNTMSDEL 223
Cdd:cd06225 1 TRPLRRLTEAARRIAEGDLDVRVPVRSK-DEIGELARAFNQMAERL 45
|
|
| Tar |
COG0840 |
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms]; |
1-249 |
1.27e-06 |
|
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];
Pssm-ID: 440602 [Multi-domain] Cd Length: 533 Bit Score: 51.17 E-value: 1.27e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505191104 1 MKRLLAPLSIVNQVALLMLLSGILGVAGMGISAWMSQSIQGNAHAINKAGSLRMQSYRLLAQVPLDERHEALIRELERDE 80
Cdd:COG0840 30 LILLALLLAALTALALLLLLSLLALLLLLLLLALALLLVLLALLLLLALVVLLALLLALLLLLLALLALALAALALLAAL 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505191104 81 NSPDLQRSVEQEGLTQPFDTLRDYWQQTLQPRLRSAQRPADAAPQVAHFVQLLDKLVSDIDRQTERRLLMVTLVQAGFIA 160
Cdd:COG0840 110 AALLALLELLLAALLAALAIALLALAALLALAALALALLALALLAAAAAAAAALAALLEAAALALAAAALALALLAAALL 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505191104 161 LTLLLLIGTTCYLRRRLLHPWRQLVEMALAVGRGDFSRRFAQRGhQDEMASLGGALNTMSDELSATYSGLEQ---RVAEK 237
Cdd:COG0840 190 ALVALAIILALLLSRSITRPLRELLEVLERIAEGDLTVRIDVDS-KDEIGQLADAFNRMIENLRELVGQVREsaeQVASA 268
|
250
....*....|..
gi 505191104 238 TADLQQKNQMLS 249
Cdd:COG0840 269 SEELAASAEELA 280
|
|
| HATPase_NtrY-like |
cd16944 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
507-586 |
1.92e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.
Pssm-ID: 340420 [Multi-domain] Cd Length: 108 Bit Score: 46.76 E-value: 1.92e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505191104 507 REALSNILKHAAAS---------EVSIQV-INKRGEVTLSVCDNGRGLPAE----------TSRPDHYGL------IIMR 560
Cdd:cd16944 6 SQVLTNILKNAAEAiegrpsdvgEVRIRVeADQDGRIVLIVCDNGKGFPREmrhratepyvTTRPKGTGLglaivkKIME 85
|
90 100
....*....|....*....|....*.
gi 505191104 561 DRAkslhGRCDILPRSGGGTEVRVSF 586
Cdd:cd16944 86 EHG----GRISLSNREAGGACIRIIL 107
|
|
| NarQ |
COG3850 |
Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction ... |
39-474 |
2.77e-06 |
|
Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction mechanisms];
Pssm-ID: 443059 [Multi-domain] Cd Length: 448 Bit Score: 50.27 E-value: 2.77e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505191104 39 IQGNAHAINKAGSLRMQSYRLLAQVPLDERHEALIRELERDENSPDLQRSVEQEGLTQPFDTLRDYWQQTLQPRLRSAQR 118
Cdd:COG3850 4 LLLLALALLRLLLALLALLLLALLLLSLLALLLLLERTLLRLLSLLASAGLLAALLAALLLLLSLGLLALLLALLLLLLL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505191104 119 PADAAPQVAHFVQLLDKLVSDIDRQTERRLLMVTLVQAGFIALTLLLLIGTTCYLRRRLLHPWRQLVEMALAVGRGDFSR 198
Cdd:COG3850 84 LLLAALLSLLLLLLLLLLLLLLLLLLLLAAAINRKLALLRLLLALLLALLLAYLLRRRIVRPLRRLTQAAERIARGDFDA 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505191104 199 RFAQRGhQDEMASLGGALNTMSDELSATYSGLEQ-RVAEKTADLQQKNQMLSFLYRASRLLHASEPLCSRLTPLLNQLQI 277
Cdd:COG3850 164 RVPVSG-RDELGTLARAFNRMADELQELYAELEEeEELEAELELLALLDELLLLAALLLLLALLLALLLAALLAALLLLL 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505191104 278 LTPLRAIQVRLYENDSREPLLQLSGNQPLRPEHCHNPVCSACLHDSDRQHPDNPSLSWSLSDKLGDYGVIVAQHAPQQPL 357
Cdd:COG3850 243 LLQDALAESELLALNILAGLLELLLALLLLLLASALLLLELELLALLLELVELLALAAAEEALLLLVELAALLLLLLLQA 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505191104 358 NDEHRQLVNTLVEQLTSVLAIERQVDHQQQLMLMEERAAIARELHDSIAQSLSCLKMQIACLQMQGETLSSASQALVQQM 437
Cdd:COG3850 323 IANASLLLIALASVVAALLELASILALQAALEAAAAGAALAAAAAAAGLARALAQAGADAAEALGLLAEASEGAAGQGAG 402
|
410 420 430
....*....|....*....|....*....|....*..
gi 505191104 438 REELNGAYRQLRELLTTFRLQLTEPGLLAALQSTVAE 474
Cdd:COG3850 403 LVDVEGGVAGEGGLVVLIVSIIAGGEAIARGEALAAR 439
|
|
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
409-586 |
9.33e-06 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 48.40 E-value: 9.33e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505191104 409 LSCLKMQIACLQMQGETLSSASQALVQQMREELNGAYRQLRELLT-------TFRLQLTEPGLLAALQSTVAEFNPKL-- 479
Cdd:COG5002 180 LTSIRGYLELLLDGAADDPEERREYLEIILEEAERLSRLVNDLLDlsrlesgELKLEKEPVDLAELLEEVVEELRPLAee 259
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505191104 480 -GLNISLDYQLGPRTVPAyQAIHLLQIAREALSNILKHAAA-SEVSIQVINKRGEVTLSVCDNGRGLPAE---------- 547
Cdd:COG5002 260 kGIELELDLPEDPLLVLG-DPDRLEQVLTNLLDNAIKYTPEgGTITVSLREEDDQVRISVRDTGIGIPEEdlpriferfy 338
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 505191104 548 ---TSRPDHY-----GLIIMRDRAKSLHGRCDILPRSGGGTEVRVSF 586
Cdd:COG5002 339 rvdKSRSRETggtglGLAIVKHIVEAHGGRIWVESEPGKGTTFTITL 385
|
|
| RsbW |
COG2172 |
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; |
461-586 |
1.38e-05 |
|
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
Pssm-ID: 441775 [Multi-domain] Cd Length: 127 Bit Score: 44.90 E-value: 1.38e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505191104 461 EPGLLAALQSTVAEFNPKLGLnisldyqlgprtvPAYQAIHLLQIAREALSNILKHA----AASEVSIQVINKRGEVTLS 536
Cdd:COG2172 7 DLEDLGLARRAVRALLRELGL-------------DEDDADDLVLAVSEAVTNAVRHAyggdPDGPVEVELELDPDGLEIE 73
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 505191104 537 VCDNGRGL-------PAETSRPDHYGLIIMRDRAKSLHGRcdilpRSGGGTEVRVSF 586
Cdd:COG2172 74 VRDEGPGFdpedlpdPYSTLAEGGRGLFLIRRLMDEVEYE-----SDPGGTTVRLVK 125
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
359-586 |
1.55e-05 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 47.49 E-value: 1.55e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505191104 359 DEHRQLVNTLVEQLTSVLAIERQVDHQQQLMLMEER--------AAIArelHDsIAQSLSCLKMQIACLQMQGETLSSAS 430
Cdd:COG4191 103 AEENAELEELERDITELERAEEELRELQEQLVQSEKlaalgelaAGIA---HE-INNPLAAILGNAELLRRRLEDEPDPE 178
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505191104 431 QA--LVQQMREELNGAYRQLRELLTTFRLQLTEPGLL---AALQSTVAEFNPKLG-LNISLDYQLGPRTVPAY------- 497
Cdd:COG4191 179 ELreALERILEGAERAAEIVRSLRAFSRRDEEEREPVdlnELIDEALELLRPRLKaRGIEVELDLPPDLPPVLgdpgqle 258
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505191104 498 QAI-HLLQIAREALsnilKHAAASEVSIQVINKRGEVTLSVCDNGRGLPAE----------TSRPDHY----GLIIMRDR 562
Cdd:COG4191 259 QVLlNLLINAIDAM----EEGEGGRITISTRREGDYVVISVRDNGPGIPPEvlerifepffTTKPVGKgtglGLSISYGI 334
|
250 260
....*....|....*....|....
gi 505191104 563 AKSLHGRCDILPRSGGGTEVRVSF 586
Cdd:COG4191 335 VEKHGGRIEVESEPGGGTTFTITL 358
|
|
| HATPase_TmoS-FixL-DctS-like |
cd16920 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
521-585 |
3.54e-05 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 43.15 E-value: 3.54e-05
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 505191104 521 EVSIQV-INKRGEVTLSVCDNGRGLPAE----------TSRPDHYG--LIIMRDRAKSLHGRCDILPRSGGGTEVRVS 585
Cdd:cd16920 25 ELTIRTsPADDRAVTISVKDTGPGIAEEvagqlfdpfyTTKSEGLGmgLSICRSIIEAHGGRLSVESPAGGGATFQFT 102
|
|
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
355-586 |
5.24e-05 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 45.61 E-value: 5.24e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505191104 355 QPLNDEHRQLVNTLV-EQLTSVLAIERQVDHQQQLMLMEERAA-IArelHD------SIAQSLSCLKMQIAclqmqgetl 426
Cdd:COG3852 98 SPLRDAEGEGGVLLVlRDITERKRLERELRRAEKLAAVGELAAgLA---HEirnpltGIRGAAQLLERELP--------- 165
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505191104 427 SSASQALVQQMREELNGAYRQLRELLTTFRLQLTEPGLL---AALQSTVAEFNPKLGLNISLDYQLGPRTVPAY------ 497
Cdd:COG3852 166 DDELREYTQLIIEEADRLNNLVDRLLSFSRPRPPEREPVnlhEVLERVLELLRAEAPKNIRIVRDYDPSLPEVLgdpdql 245
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505191104 498 -QAI-HLLQIAREALSN----ILKHAAASEVSIQVINKRGEVTLSVCDNGRGLPAE----------TSRPDHYGL----- 556
Cdd:COG3852 246 iQVLlNLVRNAAEAMPEggtiTIRTRVERQVTLGGLRPRLYVRIEVIDNGPGIPEEildrifepffTTKEKGTGLglaiv 325
|
250 260 270
....*....|....*....|....*....|..
gi 505191104 557 --IImrdraKSLHGRCDILPRSGGGTEVRVSF 586
Cdd:COG3852 326 qkIV-----EQHGGTIEVESEPGKGTTFRIYL 352
|
|
| HATPase_EL346-LOV-HK-like |
cd16951 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
468-586 |
8.36e-05 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Erythrobacter litoralis blue light-activated histidine kinase 2; This domain family includes the histidine kinase-like ATPase (HATPase) domain of blue light-activated histidine kinase 2 of Erythrobacter litoralis (EL346). Signaling commonly occurs within HK dimers, however EL346 functions as a monomer. Also included in this family are the HATPase domains of ethanolamine utilization sensory transduction histidine kinase (EutW), whereby regulation of ethanolamine, a carbon and nitrogen source for gut bacteria, results in autophosphorylation and subsequent phosphoryl transfer to a response regulator (EutV) containing an RNA-binding domain. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory PAS sensor domain, while some have an N-terminal histidine kinase domain.
Pssm-ID: 340427 [Multi-domain] Cd Length: 131 Bit Score: 42.79 E-value: 8.36e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505191104 468 LQSTVAEFNPKLGLNISLDYQLGPrtVPAYQAIHLLQIAREALSNILKHA---AAS---EVSIQVINKRGEVTlsVCDNG 541
Cdd:cd16951 8 IASAINAIHAVGDIRINITGDTGP--VSSEVATAIGLVVNELLQNALKHAfsdREGgtiTIRSVVDGDYLRIT--VIDDG 83
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 505191104 542 RGLPAETS--RPDHYGLIIMRDRAKSLHGRCDILPRSGGGTEVRVSF 586
Cdd:cd16951 84 VGLPQDEDwpNKGSLGLQIVRSLVEGELKAFLEVQSAENGTRVNIDI 130
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
435-586 |
1.57e-04 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 44.45 E-value: 1.57e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505191104 435 QQMREELNGAYRQLRELLTTFRLQLTEPGLLAALQSTVAEFNPK-LGLNISLDYQLGPRTVPAYqaiHLLQIAREALSNI 513
Cdd:COG3290 217 DEALEYIDEISEELQELIDSLLSRIGNPVLAALLLGKAARARERgIDLTIDIDSDLPDLPLSDT---DLVTILGNLLDNA 293
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505191104 514 LKHAAASE-----VSIQVINKRGEVTLSVCDNGRGLPAE----------TSRPDH---YGLIIMRDRAKSLHGRCDILPR 575
Cdd:COG3290 294 IEAVEKLPeeerrVELSIRDDGDELVIEVEDSGPGIPEEllekifergfSTKLGEgrgLGLALVKQIVEKYGGTIEVESE 373
|
170
....*....|.
gi 505191104 576 SGGGTEVRVSF 586
Cdd:COG3290 374 EGEGTVFTVRL 384
|
|
| HATPase_RsbW-like |
cd16936 |
Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase ... |
508-586 |
5.16e-04 |
|
Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains; This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B.
Pssm-ID: 340413 [Multi-domain] Cd Length: 91 Bit Score: 39.17 E-value: 5.16e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505191104 508 EALSNILKHAAASEVSIQVI----NKRGEVTLSVCDNGRGLPAETSR-PDH------YGLIIMRDRAKSLHGRcdilpRS 576
Cdd:cd16936 7 EAVTNAVRHAYRHDGPGPVRleldLDPDRLRVEVTDSGPGFDPLRPAdPDAglreggRGLALIRALMDEVGYR-----RT 81
|
90
....*....|
gi 505191104 577 GGGTEVRVSF 586
Cdd:cd16936 82 PGGKTVWLEL 91
|
|
| PRK13560 |
PRK13560 |
hypothetical protein; Provisional |
379-586 |
2.02e-03 |
|
hypothetical protein; Provisional
Pssm-ID: 106506 [Multi-domain] Cd Length: 807 Bit Score: 41.20 E-value: 2.02e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505191104 379 ERQVDHQQQLMLMEERAAIARELHDSIAQSL----SCLKMQIACLQMQG-ETLSSASQALVQQMREELNGAYRQLrellt 453
Cdd:PRK13560 590 ERKHAEEKIKAALTEKEVLLKEIHHRVKNNLqiisSLLDLQAEKLHDEEaKCAFAESQDRICAMALAHEKLYQSE----- 664
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505191104 454 tfrlQLTEPGLLAALQSTVAEFNPKLGLN---ISLDYQLGPRTVPAYQAIHLLQIAREALSNILKHA----AASEVSIQV 526
Cdd:PRK13560 665 ----DLADIDFLDYIESLTAHLKNSFAIDfgrIDCKIDADDGCLDIDKAIPCGLIISELLSNALKHAfpdgAAGNIKVEI 740
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 505191104 527 INKR-GEVTLSVCDNGRGLPA--ETSRPDHYGLIIMRDRAKSLHGrcDILPRSGGGTEVRVSF 586
Cdd:PRK13560 741 REQGdGMVNLCVADDGIGLPAgfDFRAAETLGLQLVCALVKQLDG--EIALDSRGGARFNIRF 801
|
|
| HATPase_LytS-like |
cd16957 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
494-547 |
3.29e-03 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis LytS and Staphylococcus aureus LytS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), and a GAF sensor domain; most contain a DUF3816 domain.
Pssm-ID: 340433 [Multi-domain] Cd Length: 106 Bit Score: 37.40 E-value: 3.29e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*....
gi 505191104 494 VPAYqaihLLQIAREalsNILKHAAAS-----EVSIQVINKRGEVTLSVCDNGRGLPAE 547
Cdd:cd16957 1 VPPF----ALQVLVE---NAIRHAFPKrkennEVRVVVKKDQHKVHVSVSDNGQGIPEE 52
|
|
| HATPase_c_2 |
pfam13581 |
Histidine kinase-like ATPase domain; |
461-586 |
3.65e-03 |
|
Histidine kinase-like ATPase domain;
Pssm-ID: 433327 [Multi-domain] Cd Length: 127 Bit Score: 37.65 E-value: 3.65e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505191104 461 EPGLLAALQSTVAEFNPKLGLnisldyqlgprtvPAYQAIHLLQIAREALSNILKHA----AASEVSIQVINKRGEVTLS 536
Cdd:pfam13581 4 DPEQLRAARRVLEAVLRRAGL-------------PEELLDEVELAVGEACTNAVEHAyregPEGPVEVRLTSDGGGLVVT 70
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 505191104 537 VCDNGRGLPAETSRPDH------------YGLIIMRdrakSLHGRCDIlPRSGGGTEVRVSF 586
Cdd:pfam13581 71 VADSGPPFDPLTLPPPDleepdedrkeggRGLALIR----GLMDDVEY-TRGGEGNTVRMRK 127
|
|
| chemoreceptor_sensor |
cd00181 |
4-helix bundle ligand binding sensor domain of chemoreceptors such as Tar or Tsr; The ligand ... |
37-145 |
4.17e-03 |
|
4-helix bundle ligand binding sensor domain of chemoreceptors such as Tar or Tsr; The ligand binding sensor domain of chemoreceptors and related sensor histidine kinases forms homodimers and binds to ligands via the dimerization interface, a feature that appears to be conserved in this domain superfamily. This family includes ligand binding sensor domain of several chemoreceptors, such as Escherichia coli Tar, Tsr, NarQ, NarX, Pseudomonas aeruginosa KinB, Rhodopseudomonas palustris histidine kinase HK9 chemoreceptors, Comamonas testosteroni CNB-2 MCP2201 and Anaeromyxobacter dehalogenans histidine kinase Adeh_2942, among others.
Pssm-ID: 438624 [Multi-domain] Cd Length: 119 Bit Score: 37.49 E-value: 4.17e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505191104 37 QSIQGNAHAINKAGSLRMQSYRLLAQVPL---DERHEALIRELERDENSPDLQRSVEQEGLTQP------FDTLRDYWQQ 107
Cdd:cd00181 1 QEIRQQASAISSLESLVLQARVTLRAEALtgvEELGDALIRALKQTAAVLAQFRALTRDPPEAEaeildkVQDYQKALAA 80
|
90 100 110
....*....|....*....|....*....|....*...
gi 505191104 108 TLQprLRSAQRPADAAPQVAHFVQLLDKLVSDIDRQTE 145
Cdd:cd00181 81 LIP--ALLERGAESALFDQSEAQGGLELLLSLLQQLTA 116
|
|
| |
