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Conserved domains on  [gi|505233062|ref|WP_015420164|]
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MULTISPECIES: universal stress protein [unclassified Hydrogenobaculum]

Protein Classification

universal stress protein( domain architecture ID 10001747)

universal stress protein (USP) enhances the rate of cell survival during prolonged exposure to stress agents

CATH:  3.40.50.620
Gene Ontology:  GO:0042802
PubMed:  23745136|9405142|12732303
SCOP:  8083864

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
UspA COG0589
Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];
1-150 2.03e-18

Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];


:

Pssm-ID: 440354  Cd Length: 136  Bit Score: 79.19  E-value: 2.03e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505233062   1 MFKRVIAGLDGSKPSFVASHYGLELGSKLNIPVVGIHVLDSMLTEESLLADLAgvlgfsyyegisakvkEFLEKESEALL 80
Cdd:COG0589    1 MYKRILVPTDGSEEAERALEYAAELAKALGAELHLLHVVDPPPSAAAGPEELE----------------EELREEAEEAL 64

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 505233062  81 DEFSALGRKLNAKVSTLQTWGNPAKEIALQGDLEDI--IFVGkpNHDKS-IKGIHISSVSEQVIKRAECPVFV 150
Cdd:COG0589   65 EEAAERLEEAGVEVETVVREGDPAEAILEAAEELDAdlIVMG--SRGRSgLRRLLLGSVAERVLRHAPCPVLV 135
UspA COG0589
Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];
158-271 2.40e-10

Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];


:

Pssm-ID: 440354  Cd Length: 136  Bit Score: 57.24  E-value: 2.40e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505233062 158 PIENIMICHDGKDEDDKLLDFTKNLNNIYNAKVFLYHADEFGSKKEKLEKLSKD-------------------YG--FEL 216
Cdd:COG0589    1 MYKRILVPTDGSEEAERALEYAAELAKALGAELHLLHVVDPPPSAAAGPEELEEelreeaeealeeaaerleeAGveVET 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 505233062 217 IVEKAVAEEGIVSNAENLKIDLVIMGSHKKKLV-HFFMGSTTTFVFHYIKTNMLVV 271
Cdd:COG0589   81 VVREGDPAEAILEAAEELDADLIVMGSRGRSGLrRLLLGSVAERVLRHAPCPVLVV 136
 
Name Accession Description Interval E-value
UspA COG0589
Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];
1-150 2.03e-18

Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];


Pssm-ID: 440354  Cd Length: 136  Bit Score: 79.19  E-value: 2.03e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505233062   1 MFKRVIAGLDGSKPSFVASHYGLELGSKLNIPVVGIHVLDSMLTEESLLADLAgvlgfsyyegisakvkEFLEKESEALL 80
Cdd:COG0589    1 MYKRILVPTDGSEEAERALEYAAELAKALGAELHLLHVVDPPPSAAAGPEELE----------------EELREEAEEAL 64

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 505233062  81 DEFSALGRKLNAKVSTLQTWGNPAKEIALQGDLEDI--IFVGkpNHDKS-IKGIHISSVSEQVIKRAECPVFV 150
Cdd:COG0589   65 EEAAERLEEAGVEVETVVREGDPAEAILEAAEELDAdlIVMG--SRGRSgLRRLLLGSVAERVLRHAPCPVLV 135
USP-like cd00293
universal stress protein (USP) and similar proteins; The universal stress protein (USP) is a ...
 4-151 8.06e-13

universal stress protein (USP) and similar proteins; The universal stress protein (USP) is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. USP enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae Usp reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, although USP lacks ATP-binding activity.


Pssm-ID: 467483 [Multi-domain]  Cd Length: 135  Bit Score: 63.91  E-value: 8.06e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505233062   4 RVIAGLDGSKPSFVASHYGLELGSKLNIPVVGIHVLDSMlteeslladlagvlGFSYYEGISAKVKEFLEKESEALLDEF 83
Cdd:cd00293    1 KILVAVDGSEESERALEWALELAKRPGAELTLLHVVDPP--------------PSSSLSGGLEELADELKEEAEELLEEA 66

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 505233062  84 SALGRKLNAKVSTLQTWGNPAKEIALQGDLE--DIIFVGKpnHDKS-IKGIHISSVSEQVIKRAECPVFVA 151
Cdd:cd00293   67 KKLAEEAGVEVETIVVEGDPAEAILEEAKELgaDLIVMGS--RGRSgLKRLLLGSVSEYVLRHAPCPVLVV 135
Usp pfam00582
Universal stress protein family; The universal stress protein UspA is a small cytoplasmic ...
 5-150 4.72e-12

Universal stress protein family; The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae UspA reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, though UspA lacks ATP-binding activity.


Pssm-ID: 425765 [Multi-domain]  Cd Length: 137  Bit Score: 62.04  E-value: 4.72e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505233062    5 VIAGLDGSKPSFVASHYGLELGSKLNIPVVGIHVLDSMLTEESLLADLagvlgfsyyegiSAKVKEFLEKESEALLDEFS 84
Cdd:pfam00582   1 ILVAVDGSEESKRALEWAAELAKARGAELILLHVIDPPPSGAASLADE------------SAEEEELELELAEAEALAAA 68

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 505233062   85 ALGRKLNAKVSTLQTWGNPAKEIALQGDLE--DIIFVGkpNHDKS-IKGIHISSVSEQVIKRAECPVFV 150
Cdd:pfam00582  69 AAAEAGGVKVEVVVVVGDPAEEILEVAEEEdaDLIVMG--SRGRSgLSRLLLGSVAEYVLRHAPCPVLV 135
UspA COG0589
Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];
158-271 2.40e-10

Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];


Pssm-ID: 440354  Cd Length: 136  Bit Score: 57.24  E-value: 2.40e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505233062 158 PIENIMICHDGKDEDDKLLDFTKNLNNIYNAKVFLYHADEFGSKKEKLEKLSKD-------------------YG--FEL 216
Cdd:COG0589    1 MYKRILVPTDGSEEAERALEYAAELAKALGAELHLLHVVDPPPSAAAGPEELEEelreeaeealeeaaerleeAGveVET 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 505233062 217 IVEKAVAEEGIVSNAENLKIDLVIMGSHKKKLV-HFFMGSTTTFVFHYIKTNMLVV 271
Cdd:COG0589   81 VVREGDPAEAILEAAEELDADLIVMGSRGRSGLrRLLLGSVAERVLRHAPCPVLVV 136
USP-like cd00293
universal stress protein (USP) and similar proteins; The universal stress protein (USP) is a ...
 161-271 7.66e-10

universal stress protein (USP) and similar proteins; The universal stress protein (USP) is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. USP enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae Usp reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, although USP lacks ATP-binding activity.


Pssm-ID: 467483 [Multi-domain]  Cd Length: 135  Bit Score: 55.82  E-value: 7.66e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505233062 161 NIMICHDGKDEDDKLLDFTKNLNNIYNAKVFLYHADEFGSKKEKLEKLSKDY-----------------------GFELI 217
Cdd:cd00293    1 KILVAVDGSEESERALEWALELAKRPGAELTLLHVVDPPPSSSLSGGLEELAdelkeeaeelleeakklaeeagvEVETI 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 505233062 218 VEKAVAEEGIVSNAENLKIDLVIMGSHKK-KLVHFFMGSTTTFVFHYIKTNMLVV 271
Cdd:cd00293   81 VVEGDPAEAILEEAKELGADLIVMGSRGRsGLKRLLLGSVSEYVLRHAPCPVLVV 135
Usp pfam00582
Universal stress protein family; The universal stress protein UspA is a small cytoplasmic ...
 162-272 6.36e-09

Universal stress protein family; The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae UspA reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, though UspA lacks ATP-binding activity.


Pssm-ID: 425765 [Multi-domain]  Cd Length: 137  Bit Score: 53.18  E-value: 6.36e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505233062  162 IMICHDGKDEDDKLLDFTKNLNNIYNAKVFLYHADEFGSKKEKLEKLSKDYGFELIVEKAVAE----------------- 224
Cdd:pfam00582   1 ILVAVDGSEESKRALEWAAELAKARGAELILLHVIDPPPSGAASLADESAEEEELELELAEAEalaaaaaaeaggvkvev 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 505233062  225 --------EGIVSNAENLKIDLVIMGSHKKK-LVHFFMGSTTTFVFHYIKTNMLVVK 272
Cdd:pfam00582  81 vvvvgdpaEEILEVAEEEDADLIVMGSRGRSgLSRLLLGSVAEYVLRHAPCPVLVVR 137
 
Name Accession Description Interval E-value
UspA COG0589
Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];
1-150 2.03e-18

Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];


Pssm-ID: 440354  Cd Length: 136  Bit Score: 79.19  E-value: 2.03e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505233062   1 MFKRVIAGLDGSKPSFVASHYGLELGSKLNIPVVGIHVLDSMLTEESLLADLAgvlgfsyyegisakvkEFLEKESEALL 80
Cdd:COG0589    1 MYKRILVPTDGSEEAERALEYAAELAKALGAELHLLHVVDPPPSAAAGPEELE----------------EELREEAEEAL 64

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 505233062  81 DEFSALGRKLNAKVSTLQTWGNPAKEIALQGDLEDI--IFVGkpNHDKS-IKGIHISSVSEQVIKRAECPVFV 150
Cdd:COG0589   65 EEAAERLEEAGVEVETVVREGDPAEAILEAAEELDAdlIVMG--SRGRSgLRRLLLGSVAERVLRHAPCPVLV 135
USP-like cd00293
universal stress protein (USP) and similar proteins; The universal stress protein (USP) is a ...
 4-151 8.06e-13

universal stress protein (USP) and similar proteins; The universal stress protein (USP) is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. USP enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae Usp reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, although USP lacks ATP-binding activity.


Pssm-ID: 467483 [Multi-domain]  Cd Length: 135  Bit Score: 63.91  E-value: 8.06e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505233062   4 RVIAGLDGSKPSFVASHYGLELGSKLNIPVVGIHVLDSMlteeslladlagvlGFSYYEGISAKVKEFLEKESEALLDEF 83
Cdd:cd00293    1 KILVAVDGSEESERALEWALELAKRPGAELTLLHVVDPP--------------PSSSLSGGLEELADELKEEAEELLEEA 66

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 505233062  84 SALGRKLNAKVSTLQTWGNPAKEIALQGDLE--DIIFVGKpnHDKS-IKGIHISSVSEQVIKRAECPVFVA 151
Cdd:cd00293   67 KKLAEEAGVEVETIVVEGDPAEAILEEAKELgaDLIVMGS--RGRSgLKRLLLGSVSEYVLRHAPCPVLVV 135
Usp pfam00582
Universal stress protein family; The universal stress protein UspA is a small cytoplasmic ...
 5-150 4.72e-12

Universal stress protein family; The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae UspA reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, though UspA lacks ATP-binding activity.


Pssm-ID: 425765 [Multi-domain]  Cd Length: 137  Bit Score: 62.04  E-value: 4.72e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505233062    5 VIAGLDGSKPSFVASHYGLELGSKLNIPVVGIHVLDSMLTEESLLADLagvlgfsyyegiSAKVKEFLEKESEALLDEFS 84
Cdd:pfam00582   1 ILVAVDGSEESKRALEWAAELAKARGAELILLHVIDPPPSGAASLADE------------SAEEEELELELAEAEALAAA 68

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 505233062   85 ALGRKLNAKVSTLQTWGNPAKEIALQGDLE--DIIFVGkpNHDKS-IKGIHISSVSEQVIKRAECPVFV 150
Cdd:pfam00582  69 AAAEAGGVKVEVVVVVGDPAEEILEVAEEEdaDLIVMG--SRGRSgLSRLLLGSVAEYVLRHAPCPVLV 135
UspA COG0589
Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];
158-271 2.40e-10

Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];


Pssm-ID: 440354  Cd Length: 136  Bit Score: 57.24  E-value: 2.40e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505233062 158 PIENIMICHDGKDEDDKLLDFTKNLNNIYNAKVFLYHADEFGSKKEKLEKLSKD-------------------YG--FEL 216
Cdd:COG0589    1 MYKRILVPTDGSEEAERALEYAAELAKALGAELHLLHVVDPPPSAAAGPEELEEelreeaeealeeaaerleeAGveVET 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 505233062 217 IVEKAVAEEGIVSNAENLKIDLVIMGSHKKKLV-HFFMGSTTTFVFHYIKTNMLVV 271
Cdd:COG0589   81 VVREGDPAEAILEAAEELDADLIVMGSRGRSGLrRLLLGSVAERVLRHAPCPVLVV 136
USP-like cd00293
universal stress protein (USP) and similar proteins; The universal stress protein (USP) is a ...
 161-271 7.66e-10

universal stress protein (USP) and similar proteins; The universal stress protein (USP) is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. USP enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae Usp reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, although USP lacks ATP-binding activity.


Pssm-ID: 467483 [Multi-domain]  Cd Length: 135  Bit Score: 55.82  E-value: 7.66e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505233062 161 NIMICHDGKDEDDKLLDFTKNLNNIYNAKVFLYHADEFGSKKEKLEKLSKDY-----------------------GFELI 217
Cdd:cd00293    1 KILVAVDGSEESERALEWALELAKRPGAELTLLHVVDPPPSSSLSGGLEELAdelkeeaeelleeakklaeeagvEVETI 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 505233062 218 VEKAVAEEGIVSNAENLKIDLVIMGSHKK-KLVHFFMGSTTTFVFHYIKTNMLVV 271
Cdd:cd00293   81 VVEGDPAEAILEEAKELGADLIVMGSRGRsGLKRLLLGSVSEYVLRHAPCPVLVV 135
Usp pfam00582
Universal stress protein family; The universal stress protein UspA is a small cytoplasmic ...
 162-272 6.36e-09

Universal stress protein family; The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae UspA reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, though UspA lacks ATP-binding activity.


Pssm-ID: 425765 [Multi-domain]  Cd Length: 137  Bit Score: 53.18  E-value: 6.36e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505233062  162 IMICHDGKDEDDKLLDFTKNLNNIYNAKVFLYHADEFGSKKEKLEKLSKDYGFELIVEKAVAE----------------- 224
Cdd:pfam00582   1 ILVAVDGSEESKRALEWAAELAKARGAELILLHVIDPPPSGAASLADESAEEEELELELAEAEalaaaaaaeaggvkvev 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 505233062  225 --------EGIVSNAENLKIDLVIMGSHKKK-LVHFFMGSTTTFVFHYIKTNMLVVK 272
Cdd:pfam00582  81 vvvvgdpaEEILEVAEEEDADLIVMGSRGRSgLSRLLLGSVAEYVLRHAPCPVLVVR 137
USP_Rv2623_repeat2 cd23661
universal stress protein Rv2623 and similar proteins, USP repeat 2; Mycobacterium tuberculosis ...
 5-151 4.61e-05

universal stress protein Rv2623 and similar proteins, USP repeat 2; Mycobacterium tuberculosis universal stress protein Rv2623 regulates mycobacterial growth in vitro and in vivo and is required for the entry of the tubercle bacillus into the chronic phase of infection in the host. In addition, Rv2623 binds ATP and the growth-regulatory attribute of this USP is dependent on its ATP-binding activity. Rv2623 is thought to function as an ATP-dependent signaling intermediate in a pathway that promotes persistent infection. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae Usp reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, although Usp lacks ATP-binding activity.


Pssm-ID: 467507 [Multi-domain]  Cd Length: 133  Bit Score: 42.11  E-value: 4.61e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505233062   5 VIAGLDGSKPSFVASHYGLELGSKLNIPVVGIHVLDSMlteesllaDLAGVLGFSYYEgisakvkefLEKESEALLDEFS 84
Cdd:cd23661    2 VVVGVDGSPASELATEIAFDEASRRGVDLVALHAWSDM--------GPGGFLGIDWRE---------SEQDQERMLAERL 64

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 505233062  85 A--LGRKLNAKVSTLQTWGNPAKEIALQGDLEDIIFVGKPNHDkSIKGIHISSVSEQVIKRAECPVFVA 151
Cdd:cd23661   65 AgwQERYPDVHVHKVVVRDRPARVLLEASERAQLVVVGSHGRG-GFAGMLLGSVSRAVLHSAPCPVIVV 132
USP_At3g01520-like cd23659
universal stress protein At3g01520 and similar proteins; This subfamily includes plant and ...
 214-272 1.77e-04

universal stress protein At3g01520 and similar proteins; This subfamily includes plant and fungal proteins of unknown function, including Arabidopsis thaliana At3g01520. A. thaliana contains 44 USP domain-containing proteins; the USP domain is found either in a small protein with unknown physiological function or as an N-terminal portion of a multi-domain protein, usually a protein kinase. The gene At3g01520 of Arabidopsis thaliana encodes a 175-residue universal stress protein (USP)-like protein which is widely found in the genomes of bacteria, as well as fungi, protozoa, and plants. The bound AMP and conservation of residues in the ATP-binding loop suggest that the protein At3g01520 belongs to the ATP-binding USP subfamily. Universal stress proteins (USPs) are small cytoplasmic bacterial proteins whose expression is enhanced when the cell is exposed to stress agents. USP enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity.


Pssm-ID: 467505  Cd Length: 143  Bit Score: 40.68  E-value: 1.77e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 505233062 214 FELIVEKAVAEEGIVSNAENLKIDLVIMGSHKKKLVH-FFMGSTTTFVFHYIKTNMLVVK 272
Cdd:cd23659   84 VKVEVVAGDPGEVICKAAEELKADLIVMGSRGLGALKrTLLGSVSDYVVHHSPCPVLVVR 143
USP-E_repeat2 cd23660
Universal stress protein E, repeat 2; UspE is a tandem-type USP that consists of two USP ...
 218-272 3.59e-04

Universal stress protein E, repeat 2; UspE is a tandem-type USP that consists of two USP domains. The UspE expression levels of Escherichia coli become elevated in response to oxidative stress and DNA damaging agents, including exposure to mitomycin C, cadmium, and hydrogen peroxide. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity.


Pssm-ID: 467506  Cd Length: 148  Bit Score: 39.95  E-value: 3.59e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 505233062 218 VEKAVAEEGIVSNAENLKIDLVIMGS-HKKKLVHFFMGSTTTFVFHYIKTNMLVVK 272
Cdd:cd23660   92 VLEGLPEEVIPDFAEELDADIVVLGTvARTGLSGALIGNTAEHVLDHLNCDLLALK 147
USP_At3g01520-like cd23659
universal stress protein At3g01520 and similar proteins; This subfamily includes plant and ...
 3-150 2.30e-03

universal stress protein At3g01520 and similar proteins; This subfamily includes plant and fungal proteins of unknown function, including Arabidopsis thaliana At3g01520. A. thaliana contains 44 USP domain-containing proteins; the USP domain is found either in a small protein with unknown physiological function or as an N-terminal portion of a multi-domain protein, usually a protein kinase. The gene At3g01520 of Arabidopsis thaliana encodes a 175-residue universal stress protein (USP)-like protein which is widely found in the genomes of bacteria, as well as fungi, protozoa, and plants. The bound AMP and conservation of residues in the ATP-binding loop suggest that the protein At3g01520 belongs to the ATP-binding USP subfamily. Universal stress proteins (USPs) are small cytoplasmic bacterial proteins whose expression is enhanced when the cell is exposed to stress agents. USP enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity.


Pssm-ID: 467505  Cd Length: 143  Bit Score: 37.60  E-value: 2.30e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505233062   3 KRVIAGLDGSKPSFVASHYGLEL----GSKLNIpvvgIHVLDsmlteesllADLAGVLGFSYYEGISAKVKEFLEKESEA 78
Cdd:cd23659    1 RKVLIAVDGSEESEYALEWALENlhrpGDEVVL----LHVIE---------PPSLPAASLGSGSEEWEALEEEAREKAEK 67

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 505233062  79 LLDEFSALGRK-LNAKVSTLQTWGNPAKEIALQGDLE--DIIFVGKpnHDKS-IKGIHISSVSEQVIKRAECPVFV 150
Cdd:cd23659   68 LLEKYEKKLKEeKGIKVKVEVVAGDPGEVICKAAEELkaDLIVMGS--RGLGaLKRTLLGSVSDYVVHHSPCPVLV 141
USP-A-like cd23657
universal stress protein A and similar proteins; The universal stress protein UspA is a small ...
 156-272 2.38e-03

universal stress protein A and similar proteins; The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced several-fold when cellular viability is challenged with heat shock, nutrient starvation, stress agents which arrest cell growth, or DNA-damaging agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, suggesting that it asserts a general "stress endurance" activity. In general, these proteins form dimers and have domains for nucleotide binding activity. The crystal structure of Haemophilus influenzae UspA reveals an asymmetric dimer with a tertiary alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, but unlike MJ0577, it lacks ATP-binding activity.


Pssm-ID: 467504  Cd Length: 138  Bit Score: 37.29  E-value: 2.38e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505233062 156 YKpieNIMICHDGKDEDDKLLDFTKNLNNIYNAKVFLYHADE-----FGSKKEKLEKLSKDYGFELI------------- 217
Cdd:cd23657    1 YK---HILVAVDLSPESQSLVDKAVEIARENDAKLSLIHVDEdiseyYTGLIDVDIAALQDLESTMLeealknlselagy 77

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 505233062 218 ------VEKAVAEEGIVSNAENLKIDLVIMGSHKKklvHFF--MGSTTTFVFHYIKTNMLVVK 272
Cdd:cd23657   78 pvdhtfIGYGDLKEEILEVAKKHNVDLIVCGHHGD---FGLslLGSSARAVLNSAPCDVLIVP 137
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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