|
Name |
Accession |
Description |
Interval |
E-value |
| 2A0111 |
TIGR00890 |
oxalate/formate antiporter family transporter; This subfamily belongs to the major facilitator ... |
9-383 |
8.53e-127 |
|
oxalate/formate antiporter family transporter; This subfamily belongs to the major facilitator family. Members include the oxalate/formate antiporter of Oxalobacter formigenes, where one substrate is decarboxylated in the cytosol into the other to consume a proton and drive an ion gradient. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273323 [Multi-domain] Cd Length: 377 Bit Score: 370.24 E-value: 8.53e-127
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 9 TRWLTLFGTIVTQFALGSVYTWSLFNSALSDKIGAPISQVAFSFGLLSLGLAISSSVAGKLQERFGVKRVTMASGILLGV 88
Cdd:TIGR00890 1 RWWYVLVGTVIMCFTSGYVYTWTLLAPPLGRYFGVGVTAVAIWFTLLLIGLAMSMPVGGLLADKFGPRAVAMLGGILYGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 89 GFFLTAYSDNLMMLWLSAGvLVGLADGAGYLLTLSNCVKWFPERKGLISAFAIGSYGLGSLGFKFIDAHLLASVGLEKTF 168
Cdd:TIGR00890 81 GFTFYAIADSLAALYLTYG-LASAGVGIAYGIALNTAVKWFPDKRGLASGIIIGGYGLGSFILSPLITSVINLEGVPAAF 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 169 MIWGVIVLVMILFGATLMKDAPQQEVKTVNGVVENDFTLAQSMRKPQYWMLAVMFLTACMSGLYVIGVAKDIAQGMVkLD 248
Cdd:TIGR00890 160 IYMGIIFLLVIVLGAFLIGYPPGQLIKTNIEVSVKDYTVWEMLRTPQFWVLYLSFFLNAVSGLLLIGLYKPYGQSLG-LS 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 249 AATAANAVTVISIANLSGRLVLGILSDKIARIRVITLGQVISLVGMAALLFAP-LNEATFFAAIACVAFNFGGTITVFPS 327
Cdd:TIGR00890 239 DGFLVLAVSISSIFNGGGRPFLGALSDKIGRQKTMSIVFGISAVGMAAMLFIPmLNDVLFLATVALVFFTWGGTISLFPS 318
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 505382880 328 LVSEFFGLNNLAKNYGVIYLGFGIGSICGSLIASLF---GGFYVTFCVIFALLIISLAL 383
Cdd:TIGR00890 319 LVSDIFGPANSAANYGFLYTAKAVAGIFGGLIASHAlteIGFEYTFIVTGAFALTSLAL 377
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
10-387 |
2.47e-105 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 316.09 E-value: 2.47e-105
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 10 RWLTLFGTIVTQFALGSVYTWSLFNSALSDKIGAPISQVAFSFGLLSLGLAISSSVAGKLQERFGVKRVTMASGILLGVG 89
Cdd:cd17353 2 RWLVLLGAVLMHLILGYQYAWSVFNPPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 90 FFLTAYSDNLMMLWLSAGVLVGLADGAGYLLTLSNCVKWFPERKGLISAFAIGSYGLGSLGFKFIDAHLLASVGLEKTFM 169
Cdd:cd17353 82 FILSAFAISLPLLFLGYGVLGGIGAGIGYITPVSTAVKWFPDKRGLATGIVIAGFGLGSLIFSPLIAYLINTVGVPTTFL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 170 IWGVIVLVMILFGATLMKDAPQQEVKTVNGVVEN-------DFTLAQSMRKPQYWMLAVMFLTACMSGLYVIGVAKDIAQ 242
Cdd:cd17353 162 ILGIIFLIIIVIGAFLIRDPPKGWVPPGVDPLANnaensprDYTPREMLRTPTFWLLWLMFFLNATAGLMLIGQAKPIGQ 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 243 GMVKLDAATAANAVTVISIANLSGRLVLGILSDKIARIRVITLGQVISLVGMAALLFAPLNEATFFAAIACVAFNFGGTI 322
Cdd:cd17353 242 EFAGLDAGIAALAVSILSIFNGGGRPFWGWLSDKIGRKNTLSIAFLIQGVAMFLLPFIGSVAVLFVLGVALIGFCYGGGF 321
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 505382880 323 TVFPSLVSEFFGLNNLAKNYGVIYLGFGIGSICGSLIASLF---GGFYVTFCVIFALLIISLALSTTI 387
Cdd:cd17353 322 ALFPALTADFFGTKNAGTNYGLLYTAKGVGGLIGPIIAAYVlytGGYNAAFIIAAALSLVALALALLL 389
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
8-394 |
1.69e-54 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 185.08 E-value: 1.69e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 8 RTRWLTLFGTIVTQF-ALGSVYTWSLFNSALSDKIGAPISQVAFSFGLLSLGLAISSSVAGKLQERFGVKRVTMASGILL 86
Cdd:COG2223 1 SGRWRVLLLATLAFFlAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 87 GVGFFLTAYSDNLMMLwLSAGVLVGLADGAGYLLTLSNCVKWFP-ERKGLISAFAIGSYGLGSLGFKFIDAHLLASVGLE 165
Cdd:COG2223 81 GIGLLLLALAVSYWLL-LLLGLLLGIGGGGSFAVGIALVSKWFPpDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWR 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 166 KTFMIWGVIVLVMILFGATLMKDAPQQEVKTVNGVVEndfTLAQSMRKPQYWMLAVMFLTACMSGLYVIGVAKDIAQGMV 245
Cdd:COG2223 160 NAFLILGILLLVVAVLAWLFLRDPPAGAAAAAKASLR---DQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQF 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 246 KLDAATAANAVTVISIANLSGRLVLGILSDKIARIRVITLGQVISLVGMAALLFAPLNEATFFAAIACVAFNFGGTITVF 325
Cdd:COG2223 237 GLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGSLWLFLVLFLLLGLALGGGNGAV 316
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 505382880 326 PSLVSEFFGLNNLAKNYGVIYLGFGIGSICGSLIAS----LFGGFYVTFCVIFALLIISLALSTTIRQPQREV 394
Cdd:COG2223 317 FALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGalldATGSYTAAFLVFAVLALVALVLTLLLYRRPRRA 389
|
|
| MFS_MCT_like |
cd17314 |
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ... |
10-378 |
3.04e-35 |
|
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340872 [Multi-domain] Cd Length: 385 Bit Score: 133.69 E-value: 3.04e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 10 RWLTLFGTIVTQFAL-GSVYTWSLFNSALSDKIGAPISQVAFSFGLLSLGLAISSSVAGKLQERFGVKRVTMASGILLGV 88
Cdd:cd17314 1 RWFVLYVSFLLSAMStGFILSWSLFYQPWQDAFGYSSSQIATAASLSNLGMLLTQPILGFIADSFGPRPLMALAGIMVLA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 89 GFFLTAYSDNLMMLWLSAGVLVGLADGAGYLLTLSNCVKWFPERKGLISAFAIGSYGLGSLGFKFIDAHLLASVGLEKTF 168
Cdd:cd17314 81 GYTYLSYVFNSFPLSYACFVFIGAGTGILYGSAVLVTTQYFPDTKGLALGLPTTGYSLGLVLGSPLLRILWVFYGLALVY 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 169 MIWGVIVLVMILFGATLMKDAPQQEVKTVNGVVENDFTLAQSMRKPQYWMLAVMFLTACMSGLYVIGVAKDIAQGMVKLD 248
Cdd:cd17314 161 TILGILAAIVLSVVSLLGFKEPPDNQARLHVQKKKTQTMGEIFRDKVFWILFIAIFLVLIGGFLFIANMASLVRSLQLDA 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 249 AATAANAVTVISIANLSGRLVLGILSD-KIARIRVITLGQVISLVGMAALLFA-PLNEATFFAAIACVAFNFGGTITVFP 326
Cdd:cd17314 241 PSFVTKLMSIYGLFNAFGRLLWGIVADfFGGRLSTLSILLTILGLGLCAFLFLlKMTPVGLVLTGSLLGFSYGGLFTVYP 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 505382880 327 SLVSEFFGLNNLAKNYGVIYLGFGIGSICGSLIASLFggFYVTFCVIFALLI 378
Cdd:cd17314 321 ATVSTVFGTESFATLYGILLFAPAIGSILGPMLGAKF--YDRTPSYISAVYI 370
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
11-387 |
4.49e-30 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 119.30 E-value: 4.49e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 11 WLTLFGTIVTQF-ALGSVYTWSLFNSALSDKIGAPISQVAFSFGLLSLGLAISSSVAGKLQERFGVKRVTMASGILLGVG 89
Cdd:cd17355 2 WVVLAVTFLILIlSWGIRYYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 90 FFLTAYSDNLMMLWLSAGVLVGLADGAGYL-LTLSNCVKWFPERKGLISAFAIGSYGLGSLGFKFIDAHLLASVGLEKTF 168
Cdd:cd17355 82 LVLLALATSLWQLYLLWGLLGGGGAGTLAAvAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTAL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 169 MIWGVIVLVMILFGATLMKDAP---QQEVKTVNGVVENDFTLAQSMRKPQYWMLAVMFLTAC--MSGLYVIGVAKDIAQG 243
Cdd:cd17355 162 LVLALLALLVLVPVLLLLRRRPadlALRAYDDASPASPGSTLKEALRSASFWLLALAFFLCGfaVVGLIVHLVPYLADRG 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 244 MvklDAATAANAVTVISIANLSGRLVLGILSDKIARIRVITLGQVISLVGMAALLFAPLNEATFFAAIACVAFNFGGTIT 323
Cdd:cd17355 242 I---SPAAAAVALALIGLFNIVGRLLSGWLGDRYSPRRLLAASYALRALGLALLLLLPFPPLALLLFAALFGLGWGATVP 318
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 505382880 324 VFPSLVSEFFGLNNLAKNYGVIYLGFGIGSICGS----LIASLFGGFYVTFCVIFALLIISLALSTTI 387
Cdd:cd17355 319 LTAALAARYFGARSYGTLFGLVFAPHQLGSALGPwlggLLYDRTGSYTAAWALAVALGLIAALLVLPI 386
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
8-393 |
6.04e-24 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 102.26 E-value: 6.04e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 8 RTRWLTLFGTIVTQFALG-SVYTWSLFNSALSDKIGAPISQVAFSFGLLSLGLAISSSVAGKLQERFGVKRVTMASGILL 86
Cdd:COG2807 14 AGRWLLLLAIVLVALNLRpAITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 87 GVGFFLTAYSDNLMMLWLSAgVLVGLADGAGYLLTLSNCVKWFPERKGLISAFAIGSYGLGSLGFKFIDAHLLASVGLEK 166
Cdd:COG2807 94 AAGLLLRSLAPSVALLLAGT-ALIGAGIAVGNVLLPGLIKRWFPDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRG 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 167 TFMIWGVIVLVMILFGATLMKDAPQQEVKTVNGVvendfTLAQSMRKPQYWMLAVMFLTACMSGLYVIGVAKDIAQGMvK 246
Cdd:COG2807 173 ALAVWALLALLALLLWLPLLRRRPAAAAAAPAAA-----SLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRDA-G 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 247 LDAATAANAVTVISIANLSGRLVLGILSDKIARIR-VITLGQVISLVGMAALLFAPLneATFFAAIACVAFNFGGTITVF 325
Cdd:COG2807 247 LSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRpLLLLLGLLGLAGLLGLLLAPG--SLPWLWAVLLGLGQGGLFPLA 324
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 505382880 326 PSLVSEFFG-LNNLAKNYGVI----YLGFGIGSICGSLIASLFGGFYVTFCVIFALLIISLALSTTIRQPQRE 393
Cdd:COG2807 325 LTLIGLRARtPAEAAALSGMAqsvgYLLAALGPLLVGALHDATGSWTAALLLLAALAVLMLVAGLLAGRPYVE 397
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
11-388 |
8.35e-24 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 101.48 E-value: 8.35e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 11 WLTLFGTIVTQF-ALGSVYTWSLFNSALSDKIGAPISQVAFSFGLLSLGLAISSSVAGKLQERFGVKRVTMASGILLGVG 89
Cdd:cd17352 2 WVVVFASFLVNFfTDGILNSFGVLFVELLEEFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAALG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 90 FFLTAYSDNLMMLWLSAGVLVGLADGAGYLLTLSNCVKWFPERKGLISAFAIGSYGLGSLGFKFIDAHLLASVGLEKTFM 169
Cdd:cd17352 82 LLLSSFATSLWQLYLTYGVLGGLGLGLIYSPAIVIVGQYFEKKRGLATGIAVAGSGVGTFVFPPLLRYLLDNYGWRGALL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 170 IWGVIVLVMILFGATLmkdapqqevktvngvvendftlaQSMRKPQYWMLAVMFLTACMSGLYVIGVAKDIAQGMvKLDA 249
Cdd:cd17352 162 ILGGLCLNLCVCGLLL-----------------------RLLKDPTFVLLALGVSFAMLGFFVPFVYLPSYAKSL-GIDE 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 250 ATAANAVTVISIANLSGRLVLGILSDKIARIRVITLGQVISLVGMAALLFAPLNEATFFAAIACV-AFNFGGTITVFPSL 328
Cdd:cd17352 218 SDAAFLLSIIGISDIVGRILLGLLADKPRIGRLYLYIFTLLILGLSLLAFPLATTYVGLIVFSVLfGFCSGSYSSLTPVI 297
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 505382880 329 VSEFFGLNNLAKNYGVIYLGFGIGSICGSLIASLF----GGFYVTFCVIFALLIISLALSTTIR 388
Cdd:cd17352 298 LADLVGLEKLSNAYGLVLLFQGLAALVGPPIAGLLrdytGDYDAAFYFCGACLLLSGVLLFLLP 361
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
3-393 |
7.48e-22 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 95.71 E-value: 7.48e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 3 TSTYNRTRWLTLFGTIVTQFALGSV-YTWSLFNSALSDKIGAPISQVAFSFGLLSLGLAISSSVAGKLQERFGVKRVTMA 81
Cdd:COG2271 1 ARAPSRYRWRILALLFLAYFLNYLDrSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 82 SGILLGVGFFLTAYSDNLMMLWLSAgVLVGLADGAGYLLTLSNCVKWFPERK-GLISAFAIGSYGLGSLGFKFIDAHLLA 160
Cdd:COG2271 81 GLLLWGLATLLFGFATSFWQLLLLR-FLLGLGEAGFFPAALKLIAEWFPPKErGRALGIFNAGGPLGGALAPPLLGWLLA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 161 SVGLEKTFMIWGVIVLVMILFgatlmkdapqqevktvngvvendftlaqsmrkpQYWMLAVMFLTACMSGLYVIGVAKDI 240
Cdd:COG2271 160 AFGWRAAFLILGLPGLLLALL---------------------------------RFWLLALAYFLVYFALYGFLTWLPTY 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 241 AQGMVKLDAATAANAVTVISIANLSGRLVLGILSDKIARIR--VITLGQVISLVGMAALLFAPlNEATFFAAIACVAFNF 318
Cdd:COG2271 207 LVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRklVLAIGLLLAALALLLLALLP-SPALAIALLFLAGFGL 285
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 505382880 319 GGTITVFPSLVSEFFGLNNLAKNYGVIYLGFGIGSICGSLIASLF---GGFYVTFCVIFALLIISLALSTTIRQPQRE 393
Cdd:COG2271 286 GGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLldaTGYQAAFLLLAALALLAALLALLLLRETRK 363
|
|
| MFS_Mch1p_like |
cd17354 |
Monocarboxylate transporter-homologous (Mch) 1 protein and similar transporters of the Major ... |
10-363 |
1.79e-20 |
|
Monocarboxylate transporter-homologous (Mch) 1 protein and similar transporters of the Major Facilitator Superfamily of transporters; Yeast monocarboxylate transporter-homologous (Mch) proteins are putative transporters that do not transport monocarboxylic acids across the plasma membrane, and may play roles distinct from their mammalian counterparts. Their function has not been determined. The Mch1p-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340912 [Multi-domain] Cd Length: 385 Bit Score: 91.93 E-value: 1.79e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 10 RWLTLFGTIVTQFALGSVYTWSLFNSALSDKIGAPISQVAFSfGLLSLGLAISSSVAGKLQERFGVKRVTMASGILLGVG 89
Cdd:cd17354 2 RWLSFVAALWSQLSAGSIYLFSLYSPPLKSTLGYSQQQNNLL-SVAKDLGYLVGPLLGLLSDRLGPWLLLLIGAILFFPG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 90 FFLTAYSDNLMMLWLSAG------VLVGLADGAGYLLTLSNCVKWFPERKGLISAFAIGSYGLGSLGFKFIDAHLLASvG 163
Cdd:cd17354 81 YGVLWLVVTGLISDLSFWlmclcfFLIGNSTSSLYTAALVTCAKNFPESRGLAIGIPKGCYGLSGAIGSQLYKALFFH-D 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 164 LEKTFMIWGVIVLVMILFGATLMKDAPQQEVktvngvvendftlaQSMRKPQYWMLAVMFLTACMSGLYVIGVAKDIAQG 243
Cdd:cd17354 160 SARVFLFLAVLPAVVGLLAWFSVRIVSIEEG--------------EFLKDIDFWLLFISLFLGVGPGEMFINNLGQIGQS 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 244 MVklDAATAANAVTVISIANLSGRLVLGILSD------KIARIRVITLGQVISLVGMAALLFAPLNEAtFFAAIACVAFN 317
Cdd:cd17354 226 LT--GPSNTSTLVSLFSIFSFLGRLLSGLLSDlfvrkfRLPRPSRMVLLLLILSLGHLLQAFGLPSGA-LYVASALIGFG 302
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 505382880 318 FGGTITVFPSLVSEFFGLNNLAKNYGVIYLGFGIGSICGSLIASLF 363
Cdd:cd17354 303 YGGLFSIAPTIVSELFGLKNFGTNYGFLMLAPAIGSLIFSVIYAGV 348
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
4-353 |
9.37e-20 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 89.65 E-value: 9.37e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 4 STYNRTRWLTLFGTIVTQFALG-SVYTWSLFNSALSDKIGAPISQVAFSFGLLSLGLAISSSVAGKLQERFGVKRVTMAS 82
Cdd:COG2814 2 PATPRRRWLALLALALGAFLSGlGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 83 GILLGVGFFLTAYSDNLMMLWLsAGVLVGLADGAGYLLTLSNCVKWFP-ERKGLISAFAIGSYGLGSLGFKFIDAHLLAS 161
Cdd:COG2814 82 LLLFALGSLLCALAPSLWLLLA-ARFLQGLGAGALFPAALALIADLVPpERRGRALGLLGAGLGLGPALGPLLGGLLADL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 162 VGLEKTFMIWGVIVLVMILFGATLMKDAPQQEVKTVNGvvendfTLAQSMRKPQYWMLAVMFLTACMSGLYVIGVAKDIA 241
Cdd:COG2814 161 FGWRWVFLVNAVLALLALLLLLRLLPESRPAARARLRG------SLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYL 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 242 QGMVKLDAATAANAVTVISIANLSGRLVLGILSDKIARIRVITLGQVISLVGMAALLFAPlNEATFFAAIACVAFNFGGT 321
Cdd:COG2814 235 QEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAG-SLWLLLLALFLLGFGFGLL 313
|
330 340 350
....*....|....*....|....*....|..
gi 505382880 322 ITVFPSLVSEFFGLNNLAKNYGVIYLGFGIGS 353
Cdd:COG2814 314 FPLLQALVAELAPPEARGRASGLYNSAFFLGG 345
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
22-354 |
5.42e-17 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 81.31 E-value: 5.42e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 22 FALGSVYTWSLFNSALSDKIGAPISQVAFSFGLLSLGLAISSSVAGKLQERFGVKRVTMASGILLGVGFFLTAYSDNLMM 101
Cdd:pfam07690 8 AALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 102 LWLsAGVLVGLADGAGYLLTLSNCVKWFP-ERKGLISAFAIGSYGLGSLGFKFIDAHLLASVGLEKTFMIWGVIVLVMIL 180
Cdd:pfam07690 88 LLV-LRVLQGLGAGALFPAALALIADWFPpEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAV 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 181 FGATLMKDAPQQEVKTVNGVVENDFTLAQSMRKPQYWMLAVMFLTACMsGLYVIGVAKDIAQGMVKLDAATAANAVTVIS 260
Cdd:pfam07690 167 LLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGF-AFFGLLTYLPLYQEVLGLSALLAGLLLGLGG 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 261 IANLSGRLVLGILSDKIARIRVITLGQVISLVGMAALLFAPLNEATFFAAIACVAFNFGGTITV--FPSLVSEFFGLNNL 338
Cdd:pfam07690 246 LLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFpaLNALVSDLAPKEER 325
|
330
....*....|....*.
gi 505382880 339 AKNYGVIYLGFGIGSI 354
Cdd:pfam07690 326 GTASGLYNTAGSLGGA 341
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
40-388 |
1.80e-14 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 74.15 E-value: 1.80e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 40 KIGAPISQVAFSFGLLSLGLAISSSVAGKLQERFGVKRVTMASGILLGVGFFLTAYSDNLMMLwLSAGVLVGLADGAGYL 119
Cdd:cd17325 25 SLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQL-LLARFLQGLASAAVWP 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 120 LTLSNCVKWFP-ERKGLISAFAIGSYGLGSLGFKFIDAHLLASVGLEKTFMIWGVIVLVMILFGATLMKDAPQQEVKTVN 198
Cdd:cd17325 104 AAMALIADIAPpEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLLPEPRPPPNKRAV 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 199 GVVENDFTLAQSMRKPQYWMLAVMFLTACMSGLYVIGVAKDIAQGMVKLDAATAANAVTVISIANLSGRLVLGILSDKIA 278
Cdd:cd17325 184 SAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIG 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 279 RIRVITLGQVISLVGMAALLFAPlneaTFFAAIACVAFNFGGTITVFPS---LVSEFFGLNNLAKNYGVIYLGFGIGSIC 355
Cdd:cd17325 264 RKPLILIGLLLSAVALLLLPLAT----SFWLLLLLLALLGLGLGLVFPAtlaLLADIVPPEGRGTAMGLFNTAFSLGMVL 339
|
330 340 350
....*....|....*....|....*....|....*.
gi 505382880 356 GSLIASL---FGGFYVTFCVIFALLIISLALSTTIR 388
Cdd:cd17325 340 GPLLGGFlydAFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
1-392 |
1.92e-14 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 74.12 E-value: 1.92e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 1 MNTSTYNRTRWLTLFGTIVTQFALGSvytWSLFNSALSDKIGAPISQVAFSFGLLSLGLAISSSVAGKLQERFGVKRVTM 80
Cdd:COG0738 1 MSKKNYRRALIAIYLLFFLWGFATAL---WGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 81 ASGILLGVGFFLTAYSDNLMMLwLSAGVLVGLADGAGYLLTLSNCVKWFPERKGLISAFAIGSYGLGSLGFKFIDAHLLA 160
Cdd:COG0738 78 LGLLLMALGLLLFALAPSYPLL-LLALFLLGLGLGLLDVAANPYVAALGPETAASRLNLLHAFFSLGALLGPLLGGLLIL 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 161 S-VGLEKTFMIWGVIVLVMILFGATLMKDAPQQEVKTVNGVVENDfTLAQSMRKPQYWMLAVMFLTACMSGLYVIGVAKD 239
Cdd:COG0738 157 LgLSLSWHLPYLILAVLLLLLALLFLRSKLPEIEEEEEEAAGSAA-SLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPL 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 240 IAQGMVKLDAATAANAVTVISIANLSGRLVLGILSDKIARIRVITLGQVISLVGMAALLFAPlNEATFFAAIACVAFNFG 319
Cdd:COG0738 236 YLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAP-GPWLALIGLALVGLGLS 314
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 505382880 320 GTITVFPSLVSEFFGLNNLAKNYGVI---YLGFGIGSICGSLIASLFgGFYVTFCVIFALLIISLALSTTIRQPQR 392
Cdd:COG0738 315 LMFPTIFSLALDGLGKRTAAAVSAVLimgIVGGAIGPPLIGFLADAF-GLRAAFLVPLVCYLLILLLALALKRKRR 389
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
41-387 |
6.81e-11 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 63.21 E-value: 6.81e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 41 IGAPISQVAFSFGLLSLGLAISSSVAGKLQERFGVKRVTMASGILLGVGFFLTAYSDNLMMLWLsAGVLVGLADGAGYLL 120
Cdd:cd06174 26 FGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLLL-GRFLLGLGSGLIDPA 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 121 TLSNCVKWFPERK-----GLISAFAIGSYGLGSLGFKFIDAHLlaSVGLEKTFMIWGVIVLVMILFGATLMKDAP--QQE 193
Cdd:cd06174 105 VLALIADLFPERErgralGLLQAFGSVGGILGPLLGGILASSL--GFGWRAVFLIAAALALLAAILLLLVVPDPPesARA 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 194 VKTVNGVVENDFTLAQSMRKPQYWMLAVMFLTACMSGLYVIGVAKDIAQGMVKLDAATAANAVTVISIANLSGRLVLGIL 273
Cdd:cd06174 183 KNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLL 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 274 SDKIARIRVITLGQVISLVGMAALLFAPLNEATFFAAIACVAFNFGGTITVFPSLVSEFFGLNNLAKNYGVIYLGFGIGS 353
Cdd:cd06174 263 SDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGG 342
|
330 340 350
....*....|....*....|....*....|....
gi 505382880 354 ICGSLIASLFGGFYVTFCVIFALLIISLALSTTI 387
Cdd:cd06174 343 AIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAIL 376
|
|
| MFS_MCT11_13 |
cd17423 |
Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; ... |
56-385 |
1.31e-10 |
|
Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 11 (MCT11) and 13 (MCT13) are also called Solute carrier family 16 members 11 (SLC16A11) and 13 (SLC16A13), respectively. They are orphan transporters whose substrates are yet to be determined. MCT11 is expressed in skin, lung, ovary, breast, lung, pancreas, retinal pigment epithelium, and choroid plexus. Genetic variants in SLC16A11, the gene encoding MCT11, are associated with type 2 diabetes in Mexican and other Latin American populations. MCT13 is expressed in breast and bone marrow stem cells. MCT11/13 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340981 [Multi-domain] Cd Length: 383 Bit Score: 62.41 E-value: 1.31e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 56 SLGLAI---SSSVAGKLQERFGVKRVTMASGILLGVGFFLTAYSDNLMMLWLSAGVLVGLADGAGYLLTLSNCVKWFPER 132
Cdd:cd17423 45 SIGLAVqqlASPVGSALSTRYGARPVVMLGGLLSSLGFLLASFATSLLHLYLCIGLLSGLGWALVFAPTMATVSRYFSRR 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 133 KGLISAFAIGSYGLGSLGFKFIDAHLLASVGLEKTFMIWGVIVLVMILFGATLMKDA-PQQEVKTVNGVVENDFTLAQSM 211
Cdd:cd17423 125 RSLATGLALTGVGLSSFALSPLFQLLLDTYAWRGALLLLSALSLHLVPCGALLRPLAlPGDPPAPPRSLSAAFGLSLLTH 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 212 RKPQYWMLAVMFLTACMSGLYVIGVAKDIAQGmvkLDAATAANAVTVISIANLSGRLVLGILSDKIARIRVITLGQVISL 291
Cdd:cd17423 205 RAFLRYALATTLINTGYFIPYVHLVAHARALG---LGEYQAAFVVSVAAVADAVGRLFSGWLADLGPLRLLHLLVLWTAL 281
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 292 VGMAALLFAPLNEATFFAAIAcVAFNF--GGTITVFPSLVSEFFGLNNLAKNYGVIYLGFGIGSICGSLIASLF----GG 365
Cdd:cd17423 282 TGLSLLLLPLAKVYGSLLALA-VAYGFcaGALAPLVFSVLPELVGVERVLNATGLLQMIESVGGLLGPPLSGWLrditGD 360
|
330 340
....*....|....*....|.
gi 505382880 366 FYVTFCVIFALLII-SLALST 385
Cdd:cd17423 361 YTASFLVAGSFLLLgSLILLT 381
|
|
| MFS_MCT9 |
cd17428 |
Monocarboxylate transporter 9 of the Major Facilitator Superfamily of transporters; ... |
11-363 |
1.96e-09 |
|
Monocarboxylate transporter 9 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 9 (MCT9) is also called Solute carrier family 16 member 9 (SLC16A9). It is an orphan transporter that is expressed in a number of tissues including intestine and kidney. A missense variant of MCT9 (K258T) is associated with significant increase in susceptibility to renal overload (ROL) gout with intestinal urate underexcretion. This suggests that MCT9 may have a role in intestinal urate excretion; it is possible that it transports urate. MCT9 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340986 [Multi-domain] Cd Length: 361 Bit Score: 58.67 E-value: 1.96e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 11 WLTLFGTIVTQF-ALGSVYTWSLFNSALSDKIGAPISQVAFSFGLLSLGLAISSSVAGKLQERFGVKRVTMASGILLGVG 89
Cdd:cd17428 2 WVIVFVSFLAQFlCYGSPLAVGVLYPEWLDAFGEGKGMTAWVGSLASGVGLIASPVCSACVSSFGARPVTIFSGFMVAGG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 90 FFLTAYSDNLMMLWLSAGVLVGLADGAGYLLTLSNCVKWFPERKGLISAFAIGSYGLGSLGFKFIDAHLLASVGLEKTFM 169
Cdd:cd17428 82 LMLSAFAPNIYFLIFSYGIVVGLGCGLVYAATVTITCQYFDKRRGLALGLISTGSSVGLFIYAALQRELIELYGLDGCLL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 170 IWGVIVLVMILFGAtlmkdapqqevktvngvvendftLAQSMRKPQYWMLAVMFLTACMSGLYVIGVAKDIAQGMVKLDA 249
Cdd:cd17428 162 IVGALALNLLACGS-----------------------LMRLFKNRVFSALFIAILLFDIGAFPPSLLMEDVARSENIIEE 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 250 ATAANAVTVISIANLSGRLVLGILSDkIARIRVITLgQVISLVGM-AALLFAPLNEATFFAAIACVAFNF-GGTITVFPS 327
Cdd:cd17428 219 IALIPLVSIIGITTAIGKLILGVLAD-FKWVNSLYL-YVLTLIGMgAALLAIPFAKSYLTLAVLSAILGFlSGNWSIFPY 296
|
330 340 350
....*....|....*....|....*....|....*.
gi 505382880 328 LVSEFFGLNNLAKNYGVIYLGFGIGSICGSLIASLF 363
Cdd:cd17428 297 VTTKTVGIEKLGHAYGILMFFAGLGNSLGPPIVGWF 332
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
42-383 |
1.07e-08 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 56.56 E-value: 1.07e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 42 GAPISQVAFSFGLLSLGLAISSSVAGKLQERFGVKRVTMASGILLGVGFFLTAYSDNLMMLwLSAGVLVGLADGAGYLLT 121
Cdd:cd17333 27 NLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLF-VVLMFLAGLGAGILDTGA 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 122 LSNCVKWFPERKGLISAFAIGSYGLGSLGFKFIDAHLLASVGLEKT-FMIWGVIVLVMILFGATLMKDAPQQEVKTVNGV 200
Cdd:cd17333 106 NTFVGALFEESSATRLNVLHGFFGLGALIGPLIATSLLTSELSWSWaYLIIGLIYLLLAILILLTLFPELPSARNPQQSV 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 201 VENDFTLAQSMRKPQYWMLAVMFLTACMSGLYVIGVAKDIAQGMVKLDAATAANAVTVISIANLSGRLVLGILSDKIARI 280
Cdd:cd17333 186 GAFSASASRLLRNPSIILGALALFLYVGAETAFSSWVPSYLVEKKHVSDGLAGYLLSGFWVGITIGRLLGGPISRRIKPH 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 281 RVITLGQVISLVGMAALLFAPlNEATFFAAIACVAFNFGGTITVFPSLVSEFFGLNNlAKNYGVIYLGFGIGSICGSLIA 360
Cdd:cd17333 266 TLLVLSGSGALLGLLILLLAP-TLVVGLVATALLGLFMAALFPTILSLGISNLPYAK-GKGTSVLLAAGSIGGAIIPFIM 343
|
330 340
....*....|....*....|....*...
gi 505382880 361 SLFG-----GFYVTFCVIFALLIISLAL 383
Cdd:cd17333 344 GFIAeavgiQTAMLLITILYAIIFVLAL 371
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
29-387 |
3.07e-08 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 54.88 E-value: 3.07e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 29 TWSLFNSALSDKIGAPISQVAFSFGLLSLGLAISSSVAGKLQERFGVKRVTMASGILLGVGFFLTAYSDNLMMLWLsAGV 108
Cdd:cd17319 21 NISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYV-LRF 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 109 LVGLADGAGYLLTLSNCVKWFPER-KGLISAFAIGSYGLGSLGFKFIDAHLLASVGLEKTFMIWGVIVLVMilfgatlmk 187
Cdd:cd17319 100 LLGVAEAGFFPGAIKALAEWFPAReRGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLL--------- 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 188 dapqqevktvngvvendfTLAQSMRKPQYWMLAVMFLTACMSGLYVIGVAKDIAQGMVKLDAATAANAVTVISIANLSGR 267
Cdd:cd17319 171 ------------------AVLWWFYLRQVWGLALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGM 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 268 LVLGILSDKIARIRVITLGQVISLVGMAALLFAPLNEATFFAAIA-CVA-FNFGGTITVFPSLVSEFFGLNNLAKNYGVI 345
Cdd:cd17319 233 ILGGRLSDRLLRGARRLVIIIGLLLAAVGLLLAYLTTSPVVAVILlSLAgFGIGAASPVFWSLPADLLPGEAAATAGGLI 312
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 505382880 346 YLGFGIGSICGSLIA----SLFGGFYVTFCVIFALLIISLALSTTI 387
Cdd:cd17319 313 NSGGNLGGFVAPLLIgylvDATGSYTAAFLFLAAVALLAALLVLLL 358
|
|
| 2A0113 |
TIGR00892 |
monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic ... |
11-194 |
2.02e-07 |
|
monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273325 [Multi-domain] Cd Length: 455 Bit Score: 52.82 E-value: 2.02e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 11 WLTLFGTIVTQ-FALGSVYTWSLFNSALSDKIGAPISQVAFSFGLLSLGLAISSSVAGKLQERFGVKRVTMASGILLGVG 89
Cdd:TIGR00892 18 WVVLGATFVSIgFSYAFPKAVTVFFKELQQIFQATYSETAWISSIMLAVLYAGGPISSILVNRFGCRPVVIAGGLLASLG 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 90 FFLTAYSDNLMMLWLSAGVLVGLADGAGYLLTLSNCVKWFPERKGLISAFAIGSYGLGSLGFKFIDAHLLASVGLEKTFM 169
Cdd:TIGR00892 98 MILASFSSNVIELYLTAGFITGLGLAFNFQPSLTMLGKYFYRRRPLANGLAMAGSPVFLSTLAPLNQYLFESFGWRGSFL 177
|
170 180
....*....|....*....|....*
gi 505382880 170 IWGVIVLVMILFGATLMKDAPQQEV 194
Cdd:TIGR00892 178 ILGGLLLHCCVCGALMRPVGPSQRV 202
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
8-364 |
2.11e-07 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 52.60 E-value: 2.11e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 8 RTRWLTLFGTIVTQFALGSVYTWSLFnsALSDKIGAPISQVAFSFGLLSLGLAISSSVAG----KLQERFGVKRVTM-AS 82
Cdd:COG2211 10 KEKLAYGLGDLGLNLAFGLLSAYLLY--FYTDVLGLSAALVGLILLVARLWDAITDPLIGalsdRTRTRWGRRRPWIlIG 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 83 GILLGVGFFLTAYSDNLMMLWLSAGVLVG-LADGAGYLLTLSNCVKWFPE------RKGLISAFAIGSYGLGSLGFKFID 155
Cdd:COG2211 88 AIPLALSFVLLFTAPDLSPTGKLIYALVTyLLLGLAYTLVNIPYSALGAEltpdyeERTRLSSWRFAFAGLGGLLASVLP 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 156 AHLLASVGLEK------TFMIWGVIVLVMILFGATLMKDAPQQEVKTVNGVVendfTLAQSMRKPQYWMLAVMFLTACMS 229
Cdd:COG2211 168 PPLVAAFGGDAalgyrlTALIFAVLGLLAFLLTFFGTKERPVPEEEKVSLKE----SLKALLKNRPFLLLLLAYLLFFLA 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 230 GLYVIGVAKDIAQGMVKLDAATAANAVTVISIANLSGRLVLGILSDKIARIRVITLGQVISLVGMAALLFA-PLNEATFF 308
Cdd:COG2211 244 LALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLgPGNLWLLL 323
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 505382880 309 AAIACVAFNFGGTITVFPSLVSE----------------FFGLNNLAknygvIYLGFGIGSICGSLIASLFG 364
Cdd:COG2211 324 VLAALAGIGLGAILVLPWAMLADvvdydewktgrrreglYFGIFTFA-----IKLGQALAGALAGLLLALFG 390
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
35-384 |
3.89e-07 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 51.43 E-value: 3.89e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 35 SALSDKIGAPISQVAFSFGLLSLGLAISSSVAGKLQERFGVKRVTMASGILLGVGFFLTAYSDNLMMLWLsAGVLVGLAD 114
Cdd:cd17365 23 PALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLAL-LRFLTGLGL 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 115 GAGYLLTLSNCVKWFPE-RKGLISAFAIGSYGLGSLGFKFIDAHLLASVGLEKTFMIWGVIVLV-MILFGATLmkdapqq 192
Cdd:cd17365 102 GAAMPNAITLVSEYAPArRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGGVPPLIlLPLLRGTL------- 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 193 evktvngvvendftlaqsmrkpqywMLAVMFLtACMSGLYVIGVAKDIAQGMVKLDAATAANAVTVISIANLSGRLVLGI 272
Cdd:cd17365 175 -------------------------LLWVTFF-MGLLLVYLLNSWLPKLMVEAGYSLSQALTITLLLNIGGVIGSLLLGW 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 273 LSDKIARIRVITLGQVISLVGMAALLFAPLNEATFFAAIACVAFNFGGTITVFPSLVSEFFGLNNLAKNYGVIyLGFG-I 351
Cdd:cd17365 229 LADRFGPKRVLALFFALGAVSLALLGVSPASLVLLYVLVFLAGACVNGAQVGLYALAARFYPTEVRATGVGWA-LGVGrL 307
|
330 340 350
....*....|....*....|....*....|...
gi 505382880 352 GSICGSLIASLFGGFYVTFCVIFALLIISLALS 384
Cdd:cd17365 308 GAILGPLLGGLLLAAGLGPESVFLALAIPAALG 340
|
|
| MFS_MCT6 |
cd17425 |
Monocarboxylate transporter 6 of the Major Facilitator Superfamily of transporters; ... |
11-185 |
7.51e-07 |
|
Monocarboxylate transporter 6 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 6 (MCT6) is also called Solute carrier family 16 member 5 (SLC16A5). MCT6 has been shown to transport bumetanide, nateglinide, probenecid, and prostaglandin F2a, but not L-lactic acid, in a pH- and membrane potential-dependent manner. It may be involved in the disposition and absorption of various drugs. MCT6 is expressed in the kidney, muscle, brain, heart, pancreas, prostate, lung, and placenta. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340983 [Multi-domain] Cd Length: 364 Bit Score: 50.54 E-value: 7.51e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 11 WLTLFGTIVTQ-FALGSVYTWSLFNSALSDKIGAPISQVAFSFGLLSLGLAISSSVAGKLQERFGVKRVTMASGILLGVG 89
Cdd:cd17425 2 WVVLLATMIVQgLTLGFPSCIGIFFTDLQKEFQASNSETSWFPSIMTAVLHAGGPLCSILVERFGCRVTVMLGGLLSGVG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 90 FFLTAYSDNLMMLWLSAGVLVGLADGAGYLLTLSNCVKWFPERKGLISAFAIGSYGLGSLGFKFIDAHLLASVGLEKTFM 169
Cdd:cd17425 82 MVASSFSHSIVQLYFTAGFITGLGFCFSFQSSVTVLGFYFVRRRALANALASTGTSIGLTLWPLLSQYLLEEMGWRGSFL 161
|
170
....*....|....*.
gi 505382880 170 IWGVIVLVMILFGATL 185
Cdd:cd17425 162 VFGGVLLNCCVCGAVM 177
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
37-384 |
1.95e-06 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 49.48 E-value: 1.95e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 37 LSDKIGAPISQVAFSFGLLSLGLAISSSVAGKLQERFGVKRVTMASGILLGVGFFLTAYSDNLMMLWLSAgVLVGLADGA 116
Cdd:cd17478 22 LIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLV-ALAGIGSAA 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 117 GYLLTLSNCVKWFPERKGL-ISAFAIGsyglGSLGFKF---IDAHLLASVGLEKTFmIWGVIVLVMILFGATLMKDAPQQ 192
Cdd:cd17478 101 FHPEGARLASQAAGGRRGLaMSIFSVG----GNLGFALgplIAAALVALFGGLGLL-ILLIIPGLAVALLLLRLRPLKKP 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 193 EVKTVNGVVENDFTLaQSMRKPQYWMLAVMFLTACMS-------GLYVIGVAKDIAQGMVKLdaataanavTVISIANLS 265
Cdd:cd17478 176 EAKKAAAKSSARSTL-KGVWRALLLLLIIVFLRSWVLsslttflPFYLVQRGYSLVFAGLLL---------SLFLFAGAI 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 266 GRLVLGILSDKIARIRVITLGQVISLVGMAALLFAPLNEATFFAAIACvaFNFGGTITVFPSLVSEFFGlNNLAKNYGVI 345
Cdd:cd17478 246 GTLIGGPLSDRFGRRRVIIASLLLAAPFLLLFLLTPGIWSYILLVLAG--FLLFASFPVTVVLAQELLP-GNVGLASGLM 322
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 505382880 346 Y-LGFGIGSICGSLIASL--FGGFYVTFCVIFALLIISLALS 384
Cdd:cd17478 323 MgLSFGLGGIGAPVLGALadAFGLESVLLILALLPLLGALLA 364
|
|
| MFS_MCT14 |
cd17429 |
Monocarboxylate transporter 14 of the Major Facilitator Superfamily of transporters; ... |
53-356 |
5.10e-06 |
|
Monocarboxylate transporter 14 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 14 (MCT14) is also called Solute carrier family 16 member 14 (SLC16A14). It is an orphan transporter expressed in the brain, heart, muscle, ovary, prostate, breast, lung, pancreas, liver, spleen, and thymus. It may function as a neuronal aromatic-amino-acid transporter. MCT14 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340987 [Multi-domain] Cd Length: 361 Bit Score: 48.29 E-value: 5.10e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 53 GLLSLGLA-ISSSVAGKLQERFGVKRVTMASGILLGVGFFLTAYSDNLMMLWLSAGVLVGLADGAGYLLTLSNCVKWFPE 131
Cdd:cd17429 44 SSLSMGITlIVGPFIGLFINTCGCRKTAIIGGILTSLGWVLSAYATNVHYLFISFGVTAGIGSGMAYLPAVVMVGQYFQK 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 132 RKGLISAFAIGSYGLGSLGFKFIDAHLLASVGLEKTFMIWGVIVLVMILFGATLMKDAPQQEVKTVngvvendftlaqsm 211
Cdd:cd17429 124 RRALAQGLSTTGTGFGTFLMTILLKYLCAEFGWRNAMFIQGAVSLNLCVCGALMRLFTNKVFVAFI-------------- 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 212 rkpqYWMLavmfLTACMSGLYVIGVAkDIAQGMVKLDAATAANAVTVISIANLSGRLVLGILSDkIARIRVITLGQVISL 291
Cdd:cd17429 190 ----FWAL----FAYCSFVIPFIHLP-EIVKLYGLSEQNDKFPLTSIIAIVHIFGKVILGIICD-LPCISVWNVFILANF 259
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 505382880 292 VGMAALLFAPLNEATFFAAIACVAFNF-GGTITVFPSLVSEFFGLNNLAKNYGVIYLGFGIGSICG 356
Cdd:cd17429 260 TLGVCILILPLMHTYTGLAIVCALIGFsSGYFSLMPVVTEDLVGIKNLANAYGIIICANGISALLG 325
|
|
| MFS_MCT8_10 |
cd17420 |
Monocarboxylate transporters 8 and 10, and similar proteins of the Major Facilitator ... |
53-193 |
5.58e-06 |
|
Monocarboxylate transporters 8 and 10, and similar proteins of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 8 (MCT8) and 10 (MCT10) are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT has a preference for T3 and is also a sodium-independent transporter that mediates the uptake or efflux of aromatic acids such as Phe, Tyr, and Trp, as well as L-3,4-di-hydroxy-phenylalanine. MCT8/10 and similar proteins belong to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340978 [Multi-domain] Cd Length: 400 Bit Score: 48.29 E-value: 5.58e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 53 GLLSLGLA-ISSSVAGKLQERFGVKRVTMASGILLGVGFFLTAYSDNLMMLWLSAGVLVGLADGAGYLLTLSNCVKWFPE 131
Cdd:cd17420 49 GALAMGMIfFCSPIVSCFTDKIGCRLTAFAGAAVSFGGLLLSSFCSSIGALYFTYGIMFGCGCSFAYQPSLVILGHYFKR 128
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 505382880 132 RKGLISAFAIGSYGLGSLGFKFIDAHLLASVGLEKTFMIWGVIVLVMILFGATLMKDAPQQE 193
Cdd:cd17420 129 RLGLVNGFVTAGSSVFTVILPPLLRKLLDSYGLEGTLRVLSLFMFVLILCSFTYRPLHPSPE 190
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
56-385 |
6.46e-06 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 47.95 E-value: 6.46e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 56 SLGLAISSSVAGKLQERFGVKRVTMASGILLGVGFFLTAYSDNLMMLwLSAGVLVGLADGAGYLLTLSNCVKWF--PERK 133
Cdd:cd17473 45 ALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYAL-LASRALLGIGVAGIMTLATALIGDYFegEERA 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 134 ---GLISAFAigsyGLGSLGFKFIdAHLLASVGLEKTFMIWGVIVLVMILFGATLMKDAPQQEVKTVNGVVendfTLAQS 210
Cdd:cd17473 124 kmlGLQSAAM----SLGGVVFLLL-GGALAEIGWRAPFLVYLLALPVLILVLLFLPEPARKSKSAASPGAA----TAAAL 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 211 MRKPQYWMLAVMFLTacMSGLYVIGVAkdIAQGMVKLDAATAANAVTVISIANLSGRLV---LGILSDKIARIRVITLGQ 287
Cdd:cd17473 195 PWKRVLPIYFLAFLA--MLLFYVIPIQ--LPFLLQERGGGSAALIGLALAIASLAGAIGallFGRLKRRLGKRRLLAIGF 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 288 VISLVGMAALLFAPlNEATFFAAIACVAFNFGGTITVFPSLVSEFFGLNNLAKNYGVIYLGFGIGSICGSLIASLFGGFY 367
Cdd:cd17473 271 ALMALGFLLLALAS-GLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLVNLT 349
|
330
....*....|....*...
gi 505382880 368 VTFCVIFALLIISLALST 385
Cdd:cd17473 350 GGLSGAFLILGVLALVLA 367
|
|
| MFS_YdiM_like |
cd17396 |
Inner membrane transport protein YdiM and similar proteins of the Major Facilitator ... |
13-365 |
7.71e-06 |
|
Inner membrane transport protein YdiM and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily contains Escherichia coli inner membrane transport proteins YdiM and YdiN, which belong to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340954 [Multi-domain] Cd Length: 384 Bit Score: 47.73 E-value: 7.71e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 13 TLFGTIVTQFALG-SVYTWSLFNSALSDKIGAPISQVAFSFGLLSLGLAISSSVAGKLQERFGVKRVTMASGILLGVGFF 91
Cdd:cd17396 1 TALGLYFNYFVHGmGVIILAQNMSSLSEKWHTDVAGVAYVISGIGIGRLLTILFAGVLSDKFGRKPSVLLGMVLYALFFV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 92 LTAYSDNLMMLWLsAGVLVGLADGAGYLLTLSNCVKWFPERKGLISAFAIGSYGLGSLGFKFIDAHLLA-SVGLEKTFMI 170
Cdd:cd17396 81 GILFSPNLIIAYV-FALLAGAANSFLDTGTYPALMEAFPKASGSANILVKAFVSFGQFLLPFIIAFLAAnNLWYGWSFIV 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 171 WGVIVLVMILFGATLMkdAPQQEVKTVNGVVEndfTLAQSMRKPQYWM---LAVMFLTACMSGLYVIGV-AKDIAQGMVK 246
Cdd:cd17396 160 PAAVLVLNALLLLKLS--FPPQTVTAANTKQK---EIPVKREKPKFLIegiALILIGFTSTATFYLFSQwMPKYGSAVAG 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 247 LDAATAANAVTVISIANLSGRLVLGILSDKIAR-IRVITLGQVISLVGMAALLFAPLNEATFFAAIACVAFNFGGTITVF 325
Cdd:cd17396 235 MGEAESLKLISYYSMGSLVCVFITAVLLKRYVRpIWILVLYPIISLLALFVLYLVPSPDVCILGAFVIGFFAAGGVLQLG 314
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 505382880 326 PSLVSEFFGLNNlAKNYGVIYLGFGIGSICGSLIASLFGG 365
Cdd:cd17396 315 LTLMAEFFPKGK-GKVTGIYMIASSLANFVIPLITGIIAS 353
|
|
| PRK12307 |
PRK12307 |
MFS transporter; |
37-396 |
8.35e-06 |
|
MFS transporter;
Pssm-ID: 237051 [Multi-domain] Cd Length: 426 Bit Score: 47.62 E-value: 8.35e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 37 LSDKIGAPISQVAFsfgllsLGLAISSSVAGKLQERFGVKRVTMASGILLGVGFFLTAYSDNLMMLWLSAgVLVGLADGA 116
Cdd:PRK12307 50 LTDMEGAFLATAAF------IGRPFGGALFGLLADKFGRKPLMMWSIVAYSVGTGLSGLASGVIMLTLSR-FIVGMGMAG 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 117 GYLLTLSNCVKWFPER-KGLISAFAIGSYGLGSLGFKFIDAHLLASVGLEKTFMIWGVIVLVMILFGATLMKDAPQQEVK 195
Cdd:PRK12307 123 EYACASTYAVESWPKHlKSKASAFLVSGFGIGNIIAAYFMPSFAEAYGWRAAFFVGLLPVLLVIYIRARAPESKEWEEAK 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 196 -------TVNGVVENDFTLAQSMRKPQYWMLAVMFLTA-CMSGLY--VIGVAKDIAQGMvKLDAATAANAVTVISIANLS 265
Cdd:PRK12307 203 lsgkgkhSQSAWSVFSLSMKGLFNRAQFPLTLCVFIVLfSIFGANwpIFGLLPTYLAGE-GFDTGVVSNLMTAAAFGTVL 281
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 266 GRLVLGILSDKIARIRVITLGQVISLVGMAALLFAPLNEATFFAA-IACVAFNFGGTITVFPSLVSEFFGLNNLAKNYGV 344
Cdd:PRK12307 282 GNIVWGLCADRIGLKKTFSIGLLMSFLFIFPLFRIPQDNYLLLGAcLFGLMATNVGVGGLVPKFLYDYFPLEVRGLGTGL 361
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 345 IYLGFGIGSICGSLIASLFGGFY-----VTFCVIF--ALLIISLALSTTIR-QPQREVYK 396
Cdd:PRK12307 362 IYNLAATSGTFNSMAATWLGITMglgaaLTFIVAFwtATILLIIGLSIPDRlKARRESFQ 421
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
7-181 |
1.54e-05 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 46.77 E-value: 1.54e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 7 NRTRWLTLFGTIVTQFALGSVYTWslFNSALSDKIGAPISQVAFSFGLLSLGLAISSSVAGKLQERFGVKRVTMASGILL 86
Cdd:cd17324 197 NPRLRLAYLITFLLFGGFFALYTY--LAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLA 274
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 87 GVGFFLTAYSdNLMMLWLSAGVLVGLADGAGYLLTLSNCVKWFPERKGLISAFAIGSYGLGSLGFKFIDAHLLASVGLEK 166
Cdd:cd17324 275 AALLLLTLLG-PSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEARGLASSLYLAAYNLGGALGAALGGLVLDHGGWAG 353
|
170
....*....|....*
gi 505382880 167 TFMIWGVIVLVMILF 181
Cdd:cd17324 354 VGWVGAALLLLALLL 368
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
261-384 |
1.58e-05 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 46.51 E-value: 1.58e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 261 IANLSGRLVLGILSDKIARIRVITLGQVISLVGMAALLFAPlNEATFFAAIACVAFNFGGTITVFPSLVSEFFGLNNLAK 340
Cdd:COG2814 56 LGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAP-SLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGR 134
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 505382880 341 NYGVIYLGFGIGSICGSLIASLFG---GFYVTFCVIFALLIISLALS 384
Cdd:COG2814 135 ALGLLGAGLGLGPALGPLLGGLLAdlfGWRWVFLVNAVLALLALLLL 181
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
260-383 |
3.24e-05 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 45.49 E-value: 3.24e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 260 SIANLSGRLVLGILSDKIARIRVITLGQVISLVGMAALLFAPlNEATFFAAIACVAFNFGGTITVFPSLVSEFFGLNNLA 339
Cdd:pfam07690 42 SLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFAS-SLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERG 120
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 505382880 340 KNYGVIYLGFGIGSICGSLIASLF---GGFYVTFCVIFALLIISLAL 383
Cdd:pfam07690 121 RALGLVSAGFGLGAALGPLLGGLLaslFGWRAAFLILAILSLLAAVL 167
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
42-384 |
3.40e-05 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 45.67 E-value: 3.40e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 42 GAPISQVAFSFGLLSLGLAISSSVAGKLQERFGVKRVTMASGILLGVGFFLTAYSDNLMMLwLSAGVLVGLADGAGYLLT 121
Cdd:cd17316 32 GLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILL-LVLRFLQGIGIGGEYPGA 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 122 LSNCVKWFPERK-GLISAFAIGSYGLGSLGFKFIDAHLLASVGLEKTFMIWGVIVLVMILFGATLMKDapqqevktvngv 200
Cdd:cd17316 111 STYVAEFAPSKRrGFALGLLQSGWALGALLAALVASLLIPLLSGDWGWRILFLIGALPALLALLLRRR------------ 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 201 vendftlaqsmrkpqywMLAVMFLTACMSGLY--VIGVAKDIAQGMVKLDAATAANAVTVISIANLSGRLVLGILSDKIA 278
Cdd:cd17316 179 -----------------TLLLILLWFFISFGYygLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIG 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 279 RIRVITLGQVISLVGMAALLFAP-LNEATFFAAIACVAFNFGGTITVFPSLVSEFFGLNNLAKNYGVIY----LGFGIGS 353
Cdd:cd17316 242 RKKTLVIGLILSGILALPLFYLLsGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYnlgrLGGGGAP 321
|
330 340 350
....*....|....*....|....*....|.
gi 505382880 354 ICGSLIASLFGGFYVTFCVIFALLIISLALS 384
Cdd:cd17316 322 PLIALLLASTGGTGVPALILALLAIVALIVA 352
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
39-381 |
3.62e-05 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 45.24 E-value: 3.62e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 39 DKIGAPISQVAFSFGLLSLGLAISSSVAGKLQERFGVKRVTMASGILLGVGFFLTAYSDNLMmLWLSAGVLVGLADGAGY 118
Cdd:cd17477 24 EREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPW-VWFLLRFVMGIGLAGLF 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 119 LLTLSncvkWF-----PERKGLISAFAIGSYGLGSlgfkFIDAHLLASVGLEKTFMIWGVIVLVMILFGATLMKDAPQQE 193
Cdd:cd17477 103 VVSES----WLnalatNENRGRVLGLYSTVLGLGF----ALGPLLLALVGTAGALPFLIAAVLLLLALVPLLLTRRAAPE 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 194 VKtvngvVENDFTLAQSMRKPQYWMLAV----MFLTACMSGLYVIGVAKDIAQGMVKLdaataanAVTVISIANLSGRLV 269
Cdd:cd17477 175 IE-----EAESISLRRLLRIAPLALLGAfvagFLEGAFYSLLPLYGLRLGLSVAQAAL-------LLAAFVLGGLLLQWP 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 270 LGILSDKIARIRVITLGQVISLVGMAALLFAPlneaTFFAAIACVAFNFGGTI-TVFP---SLVSEFFGLNNLAKNYGVI 345
Cdd:cd17477 243 LGWLADRFDRRRVLLGCALLGALAALLLPLVP----GLPLALLVLLFLWGGAAgPLYTlalALAGDRLPGDELVAANAAL 318
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 505382880 346 YLGFGIGSICGSLIASLF------GGFYVTFCVIFALLIISL 381
Cdd:cd17477 319 LLLYGLGSVIGPLLAGALmdafgpHGLFLFLAAVALLFLLFL 360
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
11-181 |
5.45e-05 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 44.87 E-value: 5.45e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 11 WLTLFGTIVTQFALGSVYTwsLFNSALSDKIGAPISQVAFSFGLLSLGLAISSSVAGKLQERFGVKRVTMASGILLGVGF 90
Cdd:cd17325 202 LALFLAIFVLAFAFGALEP--FLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVAL 279
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 91 FLTAYSDNLMMLWLSAgVLVGLADG---AGYLLTLSNCVKwfPERKGLISAFAIGSYGLGSLGFKFIDAHLLASVGLEKT 167
Cdd:cd17325 280 LLLPLATSFWLLLLLL-ALLGLGLGlvfPATLALLADIVP--PEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATP 356
|
170
....*....|....
gi 505382880 168 FMIWGVIVLVMILF 181
Cdd:cd17325 357 FLAAAALLLLAAVL 370
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
268-383 |
7.67e-05 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 44.46 E-value: 7.67e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 268 LVLGILSDKIARIRVITLGQVISLVGMAALLFAPlNEATFFAAIACVAFNFGGTITVFPSLVSEFFGLNNLAKNYGVIYL 347
Cdd:cd17370 252 YPAGRLSDRIGRKKLLILGYLSLALAYLGFALGS-SLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTAYGLFNT 330
|
90 100 110
....*....|....*....|....*....|....*....
gi 505382880 348 GFGIGSICGSLIASL---FGGFYVTFCVIFALLIISLAL 383
Cdd:cd17370 331 VVGIGWLLASLIAGYlwdLISPSAAFLFSAVLALIALLL 369
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
35-385 |
9.85e-05 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 44.08 E-value: 9.85e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 35 SALSDKIGAPISQVAFSFGLLSLGLAISSSVAGKLQERFGVKRVTMASGILLGVGFFLTAYSDNLMMLwLSAGVLVGLAD 114
Cdd:cd17324 23 PDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALL-LLARALAGLAH 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 115 GAGYLLTLSNCVKWFP-ERKGLISAFAIGSYGLGSLGFKFIDAHLLASVGLEKTFMIWGVIVLVMILFGATLMKDAPQQe 193
Cdd:cd17324 102 GGFWAIAAAYAADLVPpEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLLPSLPPK- 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 194 vKTVNGVVENDFTLAQSMRKPQYWMLAVMFLTACMSGLY-VIGVakdIAQGMVKLDAATAANAVTVISIANLSGRLVLGI 272
Cdd:cd17324 181 -KPGSLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYtYLAP---FLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGR 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 273 LSDKIARIRVITLGQVISLVGMAALLFAPLNEAtFFAAIACVAFNFGGTITVFPSLVSEFFGLNN---LAKNYGVIYLGF 349
Cdd:cd17324 257 LADRGGRRALLIALLLLAAALLLLTLLGPSPLL-LLVGLVLWGLGFFAAHSALQTRVLRLAPEARglaSSLYLAAYNLGG 335
|
330 340 350
....*....|....*....|....*....|....*.
gi 505382880 350 GIGSICGSLIASLfGGFYVTFCVIFALLIISLALST 385
Cdd:cd17324 336 ALGAALGGLVLDH-GGWAGVGWVGAALLLLALLLAL 370
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
269-392 |
1.68e-04 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 43.38 E-value: 1.68e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 269 VLGILSDKIARIRVITLGQVISLVGMAALLFAPlNEATFFAAIACVAFNFGGTITVFPSLVSEFFGLNNLAKNYGV---- 344
Cdd:cd17328 53 IFGYLGDRYNRKWILAVGILIWSAATLLSSFAP-NFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVfyfa 131
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 505382880 345 IYLGFGIGSICGSLIASLFGGFYVTFCVIFAL-LIISLALSTTIRQPQR 392
Cdd:cd17328 132 IPLGSGLGYVVGGLVAQATGGWRWAFRVTGVLgVLLAILLLLFVREPPR 180
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
269-387 |
3.36e-04 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 42.18 E-value: 3.36e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 269 VLGILSDKIARIRVITLGQVISLVGMAALLFAPlNEATFFAAIACVAFnFGGTITVFPSLVSEFFGLNNLAKNYGVIYLG 348
Cdd:cd17330 53 LWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSR-NLWLLFLARFLDGL-TGGNVSVAQAYIADITDEEERAKAFGIISAA 130
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 505382880 349 FGIGSICGSLIASLF---GGFYVTFCVIFALLIISLALSTTI 387
Cdd:cd17330 131 FGLGFILGPALGGFLstpYGYALPFLVAAALALLNLVLVLFF 172
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
50-366 |
4.31e-04 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 42.34 E-value: 4.31e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 50 FSFGLLslGLAISSSVAGKLQERFGVKRVTMASGILLGVGFFLTAYSDN---LMMLWLSAGVLVGLADGAGYLLTLSNCV 126
Cdd:TIGR00895 58 FSAGLI--GMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNvtqLLILRFLAGLGLGGLMPNLNALVSEYAP 135
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 127 KWFpeRKGLISAFAIGsYGLGSLGFKFIDAHLLASVGLEKTFMIWGVIVLVMILFGAT--------LMKDAPQQEVKTVN 198
Cdd:TIGR00895 136 KRF--RGTAVGLMFCG-YPIGAAVGGFLAGWLIPVFGWRSLFYVGGIAPLLLLLLLMRflpesidfLVSKRPETVRRIVN 212
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 199 GVV-----ENDFTLAQSMRKPQYWMLAV------------MFLTAC--MSGLYVIGVAKDIAQGMVKL--DAATAANAVT 257
Cdd:TIGR00895 213 AIApqmqaEAQSALPEQKSTQGTKRSVFkalfqgktaritVLLWLLyfMLLVGVYFLTNWLPKLMVELgfSLSLAATGGA 292
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 258 VISIANLSGRLVLGILSDKIaRIRVITLGQVISLVGMAALLFAPLNEATFFAAIACVAFNFGGTITVFPSLVSEFFGLNN 337
Cdd:TIGR00895 293 LFNFGGVIGSIIFGWLADRL-GPRVTALLLLLGAVFAVLVGSTLFSPTLLLLLGAIAGFFVNGGQSGLYALMALFYPTAI 371
|
330 340
....*....|....*....|....*....
gi 505382880 338 LAKNYGViylGFGIGSIcGSLIASLFGGF 366
Cdd:TIGR00895 372 RATGVGW---AIGIGRL-GAIIGPILAGY 396
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
260-394 |
4.47e-04 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 42.21 E-value: 4.47e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 260 SIANLSGRLVLGILSDKIARIRVITLGQVISLVGMAALLFAPlNEATFFAAIACVAFNFGGTITVFPSLVSEFFGLNNLA 339
Cdd:cd17329 45 AVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAH-SPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRT 123
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 505382880 340 KNYGVIYLGFGIGSICGSLIASLFGGFYVTFCVIFALLIISLALSTTIRQPQREV 394
Cdd:cd17329 124 RAFSLLYWAINLGVAIGPLLGGLLLLYSFRLLFLAAAVLFLLAALVLLFLLPETR 178
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
47-386 |
5.95e-04 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 41.52 E-value: 5.95e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 47 QVAFSFGLLSLGLAISSSVAGKLQERFGVKRVTMASGILLGVGFFLTAYSDNLMMLWLS---AGVLVGLADGAG-YLLTL 122
Cdd:cd17371 35 EAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILralAGLGFGGEWAAGaALMAE 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 123 SNCVKWFPERKGLISAFAIGSYGLGSLGFKFIDAHLLASVGLEKTFMIwGVIVLVMILFGATLMKDAPQ-QEVKTVNGVV 201
Cdd:cd17371 115 YVPARHRGKALGYVQSGWAVGWLLATLLAALLFPLLPPEIAWRVLFLL-GALPALLVLFIRRFVKEPPQwQAARAARRHF 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 202 ENDFTLAQSMRKPQYWMLAVMFLTACMSGLYVIGVAK---DIAQGMVKLDAATAANAVTVISIANLSGRLVLGILSDKIA 278
Cdd:cd17371 194 ADRPSLRELFSPPLLRTTLLASLLATGALGGYYGITTwlpSYLTGERGLSFEGSAGYLVVTILGGFLGYLAGGFLADRIG 273
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 279 RIRVITLGQVISLVGMAALLFAPLNEATFFAAIACVAFNFGGTITVFPSLVSEFFGLNNLAKNYGVIY-LGFGIGSICGS 357
Cdd:cd17371 274 RRNNFALFALGSAISILLYFFLPLSPTLILILGFPLGFFASGPFSGMGAYLTELFPTAVRATAQGFCYnVGRIIGALFPF 353
|
330 340 350
....*....|....*....|....*....|....*.
gi 505382880 358 LIASL-----FGGFYVTFCVI--FALLIISLALSTT 386
Cdd:cd17371 354 LVGFLatsgsLGTAIAVFAAVyyIAGLVLALLLPET 389
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
42-383 |
1.03e-03 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 41.02 E-value: 1.03e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 42 GAPISQVAFSFGLLSLGLAISSSVAGKLQERFGVKRVTMASGILLGVGFFLTAYSDNLMMLWLsAGVLVGLADGAGYLLT 121
Cdd:cd17320 30 GASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLI-ARFLQGLGAAAGSVVA 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 122 LSNCVKWFPERK--------GLISAFA------IGSYGLGSLGFKFIDAhLLASVGLektfmiwGVIVLVMILFGATLMK 187
Cdd:cd17320 109 RAIVRDLYSGAElakifsllMMILAIApalaplLGGLLLLFFGWRAIFV-FLALLGL-------LLLLLVLLFLPETLPE 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 188 DAPQQEVKTVNGVvendftLAQSMRKPQYWMLAVMfLTACMSGLYV-IGVAKDIAQGMVKLDAATAANAVTVISIANLSG 266
Cdd:cd17320 181 EKRKPLLSSLLRA------YKRVLKNRRFLGYALA-LGLSFAGLFAyLAAAPFIYIEQLGLSPAQFGLLFALNAIALILG 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 267 RLVLGILSDKIARIRVITLGQVISLVGMAALLFA----PLNEATFFAAIACVAFNFGGTITVFPSLVSEFFGlnNLAKNY 342
Cdd:cd17320 254 SLLNGRLVRRFGPRRLLRLGLLLLLAAALVLLLAallgGLSLWPLVAPLFLIFFGFGLIFPNATSLALEPFP--HVAGTA 331
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 505382880 343 GVIY--LGFGIGSICGSLIASLFGGFYVTFC-VIFALLIISLAL 383
Cdd:cd17320 332 SALLgfLQFLIGALAGALVGLLPNGTALPMGlLILVLGLLALLL 375
|
|
| MFS_MCT3_4 |
cd17430 |
Monocarboxylate transporters 9 and 14, and similar proteins of the Major Facilitator ... |
11-140 |
1.28e-03 |
|
Monocarboxylate transporters 9 and 14, and similar proteins of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 3 (MCT3) and 4 (MCT4) are also called Solute carrier family 16 members 8 (SLC16A8) and 3 (SLC16A3), respectively. They are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT3 is preferentially expressed in the basolateral membrane of the retinal pigment epithelium and plays a role in pH and ion homeostasis of the outer retina by facilitating the transport of lactate and H(+) out of the retina. Mice deficient with MCT3 display altered visual function. MCT4 is highly expressed in tissues dependent on glycolysis, and it plays an important role in lactate efflux from cells. MCT4 is expressed in neurons and astrocytes; it has been found to play a role in neuroprotective mechanism of ischemic preconditioning in animals (in the gerbil) with transient cerebral ischemia. Increased MCT4 expression has also been correlated with worse prognosis across many cancer types. MCT3/4 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340988 [Multi-domain] Cd Length: 368 Bit Score: 40.48 E-value: 1.28e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 11 WLTLFGT-IVTQFALGSVYTWSLFNSALSDKIGAPISQVAFSFGLLSLGLAISSSVAGKLQERFGVKRVTMASGILLGVG 89
Cdd:cd17430 2 WAVLFGCfVITGFSYAFPKAVSVFFKELMREFGVGYSDTAWISSILLAMLYGTGPLCSILVNRFGCRPVMLVGGLLASLG 81
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 505382880 90 FFLTAYSDNLMMLWLSAGVLVGLADGAGYLLTLSNCVKWFPERKGLISAFA 140
Cdd:cd17430 82 MILASFCTSIIQLYLTAGVITGLGLALNFQPSLIMLGRYFDKRRPLANGLA 132
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
36-389 |
1.74e-03 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 40.23 E-value: 1.74e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 36 ALSDKIGAPISQVAFSFGLLSLGLAISSSVAGKLQERFGVKRVTMASGILLGVGFFLTAYSDNLMMLwLSAGVLVGLADG 115
Cdd:cd17321 21 TIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFL-IAARALQGIGAA 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 116 AGYLLTLSNCVKWFPE--RKGLISAFAIGSYGLGSLGFkFIDAHLLASVGLEKTFMIWGVIVLVMILFGATlmkdapqqe 193
Cdd:cd17321 100 AIMPASLALIAATFPGerRGRALGLWGAVVGIGAALGP-LLGGLLLELFGWRWIFLINVPIGLVALLLART--------- 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 194 vktvngvvendFTLAqsmrkpqywMLAVMFLTACMSGLYVIGVAkdIAQGMVKLDAATAANAVTVISIANLSGRLVLGIL 273
Cdd:cd17321 170 -----------FSGA---------VLAAFLLGAALGGLLFLLPL--YLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRL 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 274 SDKIARIRVITLGQVISLVGMAALLFAPLNEATFFAAIACVAFNFGGTITVFPSLVSEFF-----------GLNNLAKNY 342
Cdd:cd17321 228 ADRFGPRLVLVAGLLLTAVGLLLLALLGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSsvpkekagaasGILNTARQL 307
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 505382880 343 GviyLGFGIGsICGSLIASLFGGFYVTFCVIFALLIISLALSTTIRQ 389
Cdd:cd17321 308 G---GALGVA-LLGALLTAGLSANLGDSGVAALLSAAAAAFAAGFHL 350
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
22-319 |
1.76e-03 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 40.30 E-value: 1.76e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 22 FALGSVYTWSLFnsaLSDKIGAPISQVAFSFGLLSLGLAISSSVAGKLQERFGVKRVTMASGILLGVGFFLTAYSDNLMM 101
Cdd:cd17475 10 LVAQGIPALAPF---LQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPV 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 102 LwLSAGVLVGLADGAGYLLTLSNCVKWFPERKgliSAFAIG--------SYGLGSLGFKFIDAHLlasvGLEKTFMIWGV 173
Cdd:cd17475 87 L-LVLLFLVGAGYGSVQPGGGRAIMRWFPPRE---RGLAMGirqtgvplGGALAAALLPPLALHY----GWRAAFVVAGL 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 174 IVLVMILFGATLMKDAPQQEVKTVNGVVENdFTLAQSMRKPQYW--MLAVMFLTACMSGL--YVIGVAKDIaqgmVKLDA 249
Cdd:cd17475 159 VSILAAVLFWLFYREPPAASAATESASTLL-RSLKEVLRNRDVWliAIAGALLVAPQFALltFLLLFLHDH----LGLSV 233
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 505382880 250 ATAANAVTVISIANLSGRLVLGILSDKI-ARIRVITLGQVISLVGMAALLFAPLNEATFFAAIACVAFNFG 319
Cdd:cd17475 234 VAAGALLAVAQLGGALGRIGLGRVSDRVfGGRRRPVLVITAAIAAAALLVLSLLSPGTPLWLLVLLLILLG 304
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
130-393 |
1.97e-03 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 40.14 E-value: 1.97e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 130 PERKGLISAFAigsYGLGSLG-----------------FKFIDAHLLASVGLEKTFMIWGVIVLVMILFgatlMKDAPQQ 192
Cdd:COG2270 139 PEEIGRVSGLG---WALGYLGgvllllinlalflkpeaFGLPDAGEAVRISFLLTALWWLLFALPLFLF----LPERPRP 211
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 193 EVKTVNGVVENDF-----TLAQSMRKPQYW--MLAVMFLTACMSGLYVIGVakDIAQGMVKLDAATAANAVTVISIANLS 265
Cdd:COG2270 212 GPAPPRGAVRAGFrelrrTLRELRRYRDLLrfLLAYFFYRDGVQTVIAFAG--IYAAGVLGFSTTELIVFGLLVQIVAAL 289
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 266 GRLVLGILSDKIARIRVITLGqVISLVGMAALLFAPLNEATFFAAIACVAFNFGGTITVFPSLVS---------EFFGLN 336
Cdd:COG2270 290 GALLFGRLDDRIGPKRVILVS-LVIWIVVCLAAYFLTTALAFWILGLLIGLVMGGIQALSRSLLArlippgreaEFFGLY 368
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 505382880 337 NLAKNYGVIylgfgIGSICGSLIASLFGGFYVTFCVIFALLIISLALSTTIRQPQRE 393
Cdd:COG2270 369 ALSGKAASF-----LGPLLFGLVTQLTGSQRLGILSLIVFFVIGLVLLLRVKVPRGR 420
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
217-400 |
2.20e-03 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 39.86 E-value: 2.20e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 217 WMLAVMFLTACMSGLYVIGVAKDIAQGMVKLDAATAANAVTVISIANLSGRLVLGILSDKIARIRVITLGQVISLVGMAA 296
Cdd:COG2223 7 LLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLL 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 297 LLFAPlNEATFFAAIACVAFNFGGTITVFPSLVSEFFGLNNLAKNYGVIYLGFGIGSICGSLIASL----FGGFYVTFCV 372
Cdd:COG2223 87 LALAV-SYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLliaaFGWRNAFLIL 165
|
170 180
....*....|....*....|....*...
gi 505382880 373 IFALLIISLALSTTIRQPQREVYKEAHA 400
Cdd:COG2223 166 GILLLVVAVLAWLFLRDPPAGAAAAAKA 193
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
36-379 |
2.32e-03 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 39.86 E-value: 2.32e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 36 ALSDKIGAPISQVAFSFGLLSLGLAISSSVAGKLQERFGVKRVTMASGILLGVGFFLTAYSDNLMMLwLSAGVLVGLADG 115
Cdd:cd17474 24 AIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALL-LAGRALQGIGAA 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 116 AGYLLTLSNCVKWFPERKgliSAFAIGSY----GLGSLGFKFIDAhLLASVGLEKTFMIWGVIVLVmILFGATLMKDAPQ 191
Cdd:cd17474 103 GLGPLALTLIGDLFEGGE---RAKAMGLYeaalGLGIAVGPLLGG-LLAAISWRYPFFLLAALIPV-AFLAILFLLPEPK 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 192 QEVKTVNGVVENDFTLAQSMRkpqyWMLAVMFLTACMSGLY--VIGVAKDIAQGMVKLDAATAANAVTVISIANLSGRLV 269
Cdd:cd17474 178 EKAKSSSATKLRDLKKALRGR----GLLTFLVSAFLYFFLYfaFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLF 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 270 LG-ILSDKIARIRVITLGQVISLVGMAALLFAPlNEATFFAAIACVAFNFGGTITVFPSLVSEFFGLNNLAK----NYGV 344
Cdd:cd17474 254 VGrLLKKRFGARRILVIGLLLYALSLLLLGFVP-SLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTasslYNFV 332
|
330 340 350
....*....|....*....|....*....|....*...
gi 505382880 345 IYLGFGIGSICGSLIASLFGG---FYVTFCVIFALLII 379
Cdd:cd17474 333 RFLGQAVGPLLFGLLLEIFGLsapFLVGAAIALAAAVL 370
|
|
| MFS_MCT7 |
cd17422 |
Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; ... |
18-316 |
3.23e-03 |
|
Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 7 (MCT7) is also called Solute carrier family 16 member 6 (SLC16A6). Zebrafish MCT7 is required for hepatocyte secretion of ketone bodies during fasting; it has been shown to be a selective transporter of the major ketone body beta-hydroxybutyrate, whose abundance is increased during fasting. MCT7 is expressed in the brain, pancreas, muscle, and prostate. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340980 [Multi-domain] Cd Length: 363 Bit Score: 39.35 E-value: 3.23e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 18 IVTQFALGSVYTWSLFNSALSDKIGAPISQVAFSFGLLSLGLAISSSVAGKLQERFGVKRVTMASGILLGVGFFLTAYSD 97
Cdd:cd17422 10 FVEVFTYGVIKSFGVFFNDLMSYFNETNSRVSWIISICVFVMTFTAPLSTVLSNRFGHRPVVMVGGLLISLGMITASFAS 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 98 NLMMLWLSAGVLVGLADGAGYLLTLSNCVKWFPERKGLISAFAigSYGLGSLGFKFIDA--HLLASVGLEKTFMIWGVIV 175
Cdd:cd17422 90 SIVEMYLTIGIISGLGYCFTFLPTVTILSQYFKKRRSLVTAIA--STGECFAVFAFAPAftALKESIGWRYCLLVVGALQ 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 176 LVMILFGAtlmkdapqqevktvngvvendftLAQSMRKPQYWMLAVMFLTACMS----GLYVI------GVAKDIAQGMV 245
Cdd:cd17422 168 LNIVVCGA-----------------------LLRVLKEPGFICYALFGLFATLGffapQLYIIplslslGIDQDWAAYML 224
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 505382880 246 KldaataanavtVISIANLSGRLVLGILSDKIARIRVITLGQVISLVGMAALLFAPLNEatFFAAIACVAF 316
Cdd:cd17422 225 S-----------AMAIAELFGRISAGWVLNKCPIRKIYIELICVILLCVVLLLFPFAYG--FWSLLVCSIF 282
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
44-181 |
5.11e-03 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 38.73 E-value: 5.11e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 44 PISQVAFSFGLLSLGLAISSSVAGKLQERFGVKRVTMASGILLGVGFFLTAYSDNLMMLWLSAgVLVGLADGAGYLLTLS 123
Cdd:cd17489 225 GISNAGLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAA-VLYGLGFGLLFPALQA 303
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 505382880 124 NCVKWFP--ERKGLISAFAIG---SYGLGSLGFKFIDAHLlasvGLEKTFMIWGVIVLVMILF 181
Cdd:cd17489 304 LAVDLVPphRRGAANGTFFIFfdlGIGLGGLLLGLVAELF----GYRAMFLLAAVVVLLALVL 362
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
3-185 |
6.16e-03 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 38.25 E-value: 6.16e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 3 TSTYNRTRWLTLFGTIVTQFALG-SVYTWSLFNSALSDKIGAPISQVAFSFGLLSLGLAISSSVAGKLQERFGVKRVTMA 81
Cdd:COG0477 5 DAAPTRRRRRALLALALGTFLEGlDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLI 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 82 SGILLGVGFFLTAYSDNLMMLWLsAGVLVGLADGAGYLLTLSNCVKWFPERK-GLISAFAIGSYGLGSLGFKFIDAHLLA 160
Cdd:COG0477 85 GLLLFGLASLLCGLAPSPELLIA-ARALQGIGAGGLMPGALALIAELFPARErGRALGLWGAAIGLGLALGPLLGGLLVA 163
|
170 180
....*....|....*....|....*
gi 505382880 161 SVGLEKTFMIWGVIVLVMILFGATL 185
Cdd:COG0477 164 ALGWRWIFLINAPLGLLALVLRLRL 188
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
67-386 |
7.17e-03 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 38.39 E-value: 7.17e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 67 GKLQERFGVKRVTMASGILLGVGFFLTAYSDNLMMLWLSAGVLVGLAdGAGYLLTLSNCVKWFPERKglISAFAIGSYGL 146
Cdd:cd17341 55 GFLCDRFGGRRVFIASLLLLLIPLLALALAVSSYWGLLVLGFLLGFA-GANFASGQPWASFWFPKEK--IGGAAGGIAGA 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 147 GSLG----------FKFIDAHLLASVGLEKTFMIWGVIVLVMILFGATLMKDAPQQevktVNGVVENDFTLAQSMRKPQY 216
Cdd:cd17341 132 GNMGvavsqllaplIAGAIVFDGGFVGWRNAFFVPGILLAIAAVLVLLFGDDLPTG----KASALEFLKVQLAVLKNYRT 207
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 217 WMLAVMFLTACMSGLYVIGVAKDIAQGMVKLDAATAANAVTVISIANLSGRLVLGILSDKIARIRVITLGQVISLVGMAA 296
Cdd:cd17341 208 WILSLLYGVTFGSFVGFSNVLPTYFKTRFGLPLVTAGILAALFPLAGALARPAGGWLSDRFGGRRRLWWLFIVMTIGAAL 287
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 297 LLFAPLNEAT--------FFAAIACVAFNFGGTITVFPSLvseffglnnLAKNYGVIyLGF--GIGSICGSLIASLFG-- 364
Cdd:cd17341 288 LSLSLPTSGTnlvlflalFVALGLGAGAGNGSVFRMVPFI---------FRRELGAV-TGLvgAIGGLGGFFLPLLFGss 357
|
330 340
....*....|....*....|....*.
gi 505382880 365 ----GFYVTFCVIFALLIISLALSTT 386
Cdd:cd17341 358 almtGSGVGAFSLFGVLAVACTLLVW 383
|
|
| MFS_CsbX |
cd17337 |
CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed ... |
259-388 |
8.13e-03 |
|
CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed of Bacillus subtilis CsbX protein (also named alpha-ketoglutarate permease), Klebsiella pneumoniae D-arabinitol transporter (DalT), and similar proteins. The csbX gene is a sigmaB-controlled gene that is expressed during the stationary phase of cell growth. DalT is a pentose-specific ion symporter for D-arabinitol uptake. Most members of this family remain uncharacterized. The CsbX family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340895 [Multi-domain] Cd Length: 388 Bit Score: 38.25 E-value: 8.13e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505382880 259 ISIANLSGRLVLGILSDKIARIRVITL-GQVISLVGMAALLFAPLNEATFFAAIACVAFNFGGTIT-------VFPSLVS 330
Cdd:cd17337 253 IFLVNIFFNLIFGILGDKIGWRRTVRWfGGVGCAISTLLFYYVPQLFGHNYWAALIAAILFGIGLAgfvplsaLMPSLAP 332
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 505382880 331 EFFGLNNLAKNygviyLGFGIGSICGSLIASLFGGFYVTFCVIF---ALLIISLALSTTIR 388
Cdd:cd17337 333 EHKGAAMSILN-----LGAGLSNFVGPAIVTLFLGSFGAGGVVWifaGLYLLSAVLTLFLK 388
|
|
| |
