NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|505383100|ref|WP_015570202|]
View 

MULTISPECIES: response regulator [Enterobacter]

Protein Classification

response regulator transcription factor family protein( domain architecture ID 1000130)

response regulator transcription factor family protein such as an OmpR family response regulator transcription factor with a signal receiver (REC) domain and a helix-turn-helix (HTH) DNA-binding domain that may be part of a two-component regulatory system

CATH:  1.10.10.10|3.40.50.2300
Gene Ontology:  GO:0003677|GO:0000160|GO:0006355
PubMed:  11226872

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
ompR super family cl32374
osmolarity response regulator; Provisional
 5-235 4.66e-57

osmolarity response regulator; Provisional


The actual alignment was detected with superfamily member PRK09468:

Pssm-ID: 181883 [Multi-domain]  Cd Length: 239  Bit Score: 181.71  E-value: 4.66e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100   5 ILVVDDDVAVCELLQDVLSEHVFTVLTCHTGQdAVNRVQQDPGIALVLLDMMLPDINGLQVLLQLQKQRPSLPVVMLTGL 84
Cdd:PRK09468   8 ILVVDDDMRLRALLERYLTEQGFQVRSAANAE-QMDRLLTRESFHLMVLDLMLPGEDGLSICRRLRSQNNPTPIIMLTAK 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100  85 GSESDVVVGLEMGADDYIGKPFNPRVVVARVKAVLRRTGAldAEPAAP--RVEGITFNGWTLDTTRCELsdpQRN--TVP 160
Cdd:PRK09468  87 GEEVDRIVGLEIGADDYLPKPFNPRELLARIRAVLRRQAP--ELPGAPsqEEEVIAFGKFKLNLGTREL---FRGdePMP 161

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 505383100 161 LTQGEYGLLLALTQNARRVLSREQLLELTHSESAEVFDRTIDVLIMRLRRKIEVNPHQPLLIKTIRGLGYVFATD 235
Cdd:PRK09468 162 LTTGEFAVLKALVSHPREPLSRDKLMNLARGREYSAMERSIDVQISRLRRLIEEDPAHPRYIQTVWGLGYVFVPD 236
 
Name Accession Description Interval E-value
ompR PRK09468
osmolarity response regulator; Provisional
 5-235 4.66e-57

osmolarity response regulator; Provisional


Pssm-ID: 181883 [Multi-domain]  Cd Length: 239  Bit Score: 181.71  E-value: 4.66e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100   5 ILVVDDDVAVCELLQDVLSEHVFTVLTCHTGQdAVNRVQQDPGIALVLLDMMLPDINGLQVLLQLQKQRPSLPVVMLTGL 84
Cdd:PRK09468   8 ILVVDDDMRLRALLERYLTEQGFQVRSAANAE-QMDRLLTRESFHLMVLDLMLPGEDGLSICRRLRSQNNPTPIIMLTAK 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100  85 GSESDVVVGLEMGADDYIGKPFNPRVVVARVKAVLRRTGAldAEPAAP--RVEGITFNGWTLDTTRCELsdpQRN--TVP 160
Cdd:PRK09468  87 GEEVDRIVGLEIGADDYLPKPFNPRELLARIRAVLRRQAP--ELPGAPsqEEEVIAFGKFKLNLGTREL---FRGdePMP 161

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 505383100 161 LTQGEYGLLLALTQNARRVLSREQLLELTHSESAEVFDRTIDVLIMRLRRKIEVNPHQPLLIKTIRGLGYVFATD 235
Cdd:PRK09468 162 LTTGEFAVLKALVSHPREPLSRDKLMNLARGREYSAMERSIDVQISRLRRLIEEDPAHPRYIQTVWGLGYVFVPD 236
OmpR COG0745
DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain ...
 5-224 1.25e-49

DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 440508 [Multi-domain]  Cd Length: 204  Bit Score: 161.28  E-value: 1.25e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100   5 ILVVDDDVAVCELLQDVLSEHVFTVLTCHTGQDAVNRVQQDPgIALVLLDMMLPDINGLQVLLQLQKQRPSLPVVMLTGL 84
Cdd:COG0745    4 ILVVEDDPDIRELLADALEREGYEVDTAADGEEALELLEEER-PDLILLDLMLPGMDGLEVCRRLRARPSDIPIIMLTAR 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100  85 GSESDVVVGLEMGADDYIGKPFNPRVVVARVKAVLRRTGAldaepaaprvEGITFNGWtLDTTRCELSDPQRnTVPLTQG 164
Cdd:COG0745   83 DDEEDRVRGLEAGADDYLTKPFDPEELLARIRALLRRRAA----------EVLRVGDL-LDLAAREVTRDGE-PVELTPK 150

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100 165 EYGLLLALTQNARRVLSREQLLELTHSESaEVFDRTIDVLIMRLRRKIEvnphqPLLIKT 224
Cdd:COG0745  151 EFRLLELLMRNPGRVVSREQLLEEVWGYD-YGDDRTVDVHISRLRKKLE-----DDLIET 204
PhoB TIGR02154
phosphate regulon transcriptional regulatory protein PhoB; PhoB is a DNA-binding response ...
 1-232 1.42e-41

phosphate regulon transcriptional regulatory protein PhoB; PhoB is a DNA-binding response regulator protein acting with PhoR in a 2-component system responding to phosphate ion. PhoB acts as a positive regulator of gene expression for phosphate-related genes such as phoA, phoS, phoE and ugpAB as well as itself. It is often found proximal to genes for the high-affinity phosphate ABC transporter (pstSCAB; GenProp0190) and presumably regulates these as well. [Regulatory functions, DNA interactions, Signal transduction, Two-component systems]


Pssm-ID: 131209 [Multi-domain]  Cd Length: 226  Bit Score: 141.31  E-value: 1.42e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100    1 MKPAILVVDDDVAVCELLQDVLSEHVFTVLTCHTGQDAVNRVQqDPGIALVLLDMMLPDINGLQVLLQLQKqRPS---LP 77
Cdd:TIGR02154   1 MTRRILVVEDEPAIRELIAYNLEKAGYDVVEAGDGDEALTLIN-ERGPDLILLDWMLPGTSGIELCRRLRR-RPEtraIP 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100   78 VVMLTGLGSESDVVVGLEMGADDYIGKPFNPRVVVARVKAVLRRTGALDAEpaaprvEGITFNGWTLDTTRCELSDPQRN 157
Cdd:TIGR02154  79 IIMLTARGEEEDRVRGLETGADDYITKPFSPRELLARIKAVLRRIRPQLSD------EVIEVGDLSLDPVAHRVFRGGQP 152

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 505383100  158 tVPLTQGEYGLLLALTQNARRVLSREQLLELTHSESAEVFDRTIDVLIMRLRRKIEVNPHQPlLIKTIRGLGYVF 232
Cdd:TIGR02154 153 -LSLGPTEFRLLHFFMTHPERVYSREQLLDRVWGRDVYVEERTVDVHIRRLRKALNPFGLED-PVQTVRGAGYRF 225
MtrAB_MtrA NF040689
MtrAB system response regulator MtrA;
5-230 2.68e-40

MtrAB system response regulator MtrA;


Pssm-ID: 468653 [Multi-domain]  Cd Length: 219  Bit Score: 138.08  E-value: 2.68e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100   5 ILVVDDDVAVCELLQDVLSEHVFTVLTCHTGQDAV---NRVQQDpgiaLVLLDMMLPDINGLQVLLQLQKqRPSLPVVML 81
Cdd:NF040689   1 ILVVDDDPALAEMLGIVLRAEGFETVFCADGAEAVeafREVRPD----LVLLDLMLPGMDGIEVCRQIRA-ESGVPIIML 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100  82 TGLGSESDVVVGLEMGADDYIGKPFNPRVVVARVKAVLRRTGALDAEPaaprvegITFNGWTLDTTRCELSdpqRN--TV 159
Cdd:NF040689  76 TAKSDTVDVVRGLEAGADDYVVKPFKPKELVARIRARLRRSEDEESEV-------LRIGDLTIDVAGHEVT---RGgeEI 145

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 505383100 160 PLTQGEYGLLLALTQNARRVLSREQLLEL----THSESAevfdRTIDVLIMRLRRKIEVNPHQPLLIKTIRGLGY 230
Cdd:NF040689 146 PLTPLEFDLLVALARKPGQVFSREELLEQvwgyRHAADT----RLVNVHVQRLRAKIERDPENPEIVVTVRGVGY 216
resp_reg_YycF NF040534
response regulator YycF;
5-230 2.19e-34

response regulator YycF;


Pssm-ID: 439744 [Multi-domain]  Cd Length: 231  Bit Score: 122.91  E-value: 2.19e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100   5 ILVVDDDVAVCELLQDVLSEHVFTVLTCHTGQDAVNRVQQD-PGiaLVLLDMMLPDINGLQVLLQLQKqRPSLPVVMLTG 83
Cdd:NF040534   3 ILVVDDEKPIADILEFNLKKEGYEVFCAYDGNEALELVEEEvPD--LVLLDIMLPGRDGMEVCREVRK-KYDMPIIMLTA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100  84 LGSESDVVVGLEMGADDYIGKPFNPRVVVARVKAVLRRTGALDAEPAAPRVEGITFNGWTLDTTRCELSDpQRNTVPLTQ 163
Cdd:NF040534  80 KDSEIDKVLGLELGADDYVTKPFSTRELIARVKANLRRHQQQNTEEEEEENNEIVIGSLTIHPDAYTVKK-RGETIELTH 158

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 505383100 164 GEYGLLLALTQNARRVLSREQLLELT--HSESAEVfdRTIDVLIMRLRRKIEVNPHQPLLIKTIRGLGY 230
Cdd:NF040534 159 REFELLHYLAKHIGQVMTREHLLQTVwgYDYFGDV--RTVDVTVRRLREKIEDNPSHPEWIVTRRGVGY 225
REC_OmpR cd17574
phosphoacceptor receiver (REC) domain of OmpR family response regulators; OmpR-like proteins ...
 6-105 1.31e-31

phosphoacceptor receiver (REC) domain of OmpR family response regulators; OmpR-like proteins are one of the most widespread transcriptional regulators. OmpR family members contain REC and winged helix-turn-helix (wHTH) DNA-binding output effector domain. They are involved in the control of environmental stress tolerance (such as the oxidative, osmotic and acid stress response), motility, virulence, outer membrane biogenesis and other processes. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381116 [Multi-domain]  Cd Length: 99  Bit Score: 111.73  E-value: 1.31e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100   6 LVVDDDVAVCELLQDVLSEHVFTVLTCHTGQDAVNRVQQDPgIALVLLDMMLPDINGLQVLLQLQKQRPSLPVVMLTGLG 85
Cdd:cd17574    1 LVVEDDEEIAELLSDYLEKEGYEVDTAADGEEALELAREEQ-PDLIILDVMLPGMDGFEVCRRLREKGSDIPIIMLTAKD 79

                         90       100
                 ....*....|....*....|
gi 505383100  86 SESDVVVGLEMGADDYIGKP 105
Cdd:cd17574   80 EEEDKVLGLELGADDYITKP 99
Trans_reg_C pfam00486
Transcriptional regulatory protein, C terminal;
157-232 1.58e-26

Transcriptional regulatory protein, C terminal;


Pssm-ID: 425712 [Multi-domain]  Cd Length: 77  Bit Score: 97.97  E-value: 1.58e-26
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 505383100  157 NTVPLTQGEYGLLLALTQNARRVLSREQLLELTHSESAEVFDRTIDVLIMRLRRKIEVNPHQPLLIKTIRGLGYVF 232
Cdd:pfam00486   2 EEVELTPKEFKLLELLAENPGRVVSREQLLEEVWGEDYDVDDNTVDVHISRLRKKLEDDPRDPRLIKTVRGVGYRL 77
Trans_reg_C smart00862
Transcriptional regulatory protein, C terminal; This domain is almost always found associated ...
 158-232 3.21e-23

Transcriptional regulatory protein, C terminal; This domain is almost always found associated with the response regulator receiver domain. It may play a role in DNA binding.


Pssm-ID: 214866 [Multi-domain]  Cd Length: 76  Bit Score: 89.15  E-value: 3.21e-23
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 505383100   158 TVPLTQGEYGLLLALTQNARRVLSREQLLELTHSESAEVFDRTIDVLIMRLRRKIEVNPHqPLLIKTIRGLGYVF 232
Cdd:smart00862   3 PIKLTPKEFRLLELLLRNPGRVVSREELLEAVWGDDEDVDDNTLDVHISRLRKKLEDDGD-PRLIETVRGVGYRL 76
 
Name Accession Description Interval E-value
ompR PRK09468
osmolarity response regulator; Provisional
 5-235 4.66e-57

osmolarity response regulator; Provisional


Pssm-ID: 181883 [Multi-domain]  Cd Length: 239  Bit Score: 181.71  E-value: 4.66e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100   5 ILVVDDDVAVCELLQDVLSEHVFTVLTCHTGQdAVNRVQQDPGIALVLLDMMLPDINGLQVLLQLQKQRPSLPVVMLTGL 84
Cdd:PRK09468   8 ILVVDDDMRLRALLERYLTEQGFQVRSAANAE-QMDRLLTRESFHLMVLDLMLPGEDGLSICRRLRSQNNPTPIIMLTAK 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100  85 GSESDVVVGLEMGADDYIGKPFNPRVVVARVKAVLRRTGAldAEPAAP--RVEGITFNGWTLDTTRCELsdpQRN--TVP 160
Cdd:PRK09468  87 GEEVDRIVGLEIGADDYLPKPFNPRELLARIRAVLRRQAP--ELPGAPsqEEEVIAFGKFKLNLGTREL---FRGdePMP 161

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 505383100 161 LTQGEYGLLLALTQNARRVLSREQLLELTHSESAEVFDRTIDVLIMRLRRKIEVNPHQPLLIKTIRGLGYVFATD 235
Cdd:PRK09468 162 LTTGEFAVLKALVSHPREPLSRDKLMNLARGREYSAMERSIDVQISRLRRLIEEDPAHPRYIQTVWGLGYVFVPD 236
OmpR COG0745
DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain ...
 5-224 1.25e-49

DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 440508 [Multi-domain]  Cd Length: 204  Bit Score: 161.28  E-value: 1.25e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100   5 ILVVDDDVAVCELLQDVLSEHVFTVLTCHTGQDAVNRVQQDPgIALVLLDMMLPDINGLQVLLQLQKQRPSLPVVMLTGL 84
Cdd:COG0745    4 ILVVEDDPDIRELLADALEREGYEVDTAADGEEALELLEEER-PDLILLDLMLPGMDGLEVCRRLRARPSDIPIIMLTAR 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100  85 GSESDVVVGLEMGADDYIGKPFNPRVVVARVKAVLRRTGAldaepaaprvEGITFNGWtLDTTRCELSDPQRnTVPLTQG 164
Cdd:COG0745   83 DDEEDRVRGLEAGADDYLTKPFDPEELLARIRALLRRRAA----------EVLRVGDL-LDLAAREVTRDGE-PVELTPK 150

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100 165 EYGLLLALTQNARRVLSREQLLELTHSESaEVFDRTIDVLIMRLRRKIEvnphqPLLIKT 224
Cdd:COG0745  151 EFRLLELLMRNPGRVVSREQLLEEVWGYD-YGDDRTVDVHISRLRKKLE-----DDLIET 204
PRK11083 PRK11083
DNA-binding response regulator CreB; Provisional
 1-230 2.11e-45

DNA-binding response regulator CreB; Provisional


Pssm-ID: 236838 [Multi-domain]  Cd Length: 228  Bit Score: 151.27  E-value: 2.11e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100   1 MKPAILVVDDDVAVCELLQDVLSEHVFTVLTCHTGQDAVNRVQQDPgIALVLLDMMLPDINGLQVLLQLQKQRPSLPVVM 80
Cdd:PRK11083   2 QQPTILLVEDEQAIADTLVYALQSEGFTVEWFERGLPALDKLRQQP-PDLVILDVGLPDISGFELCRQLLAFHPALPVIF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100  81 LTGLGSESDVVVGLEMGADDYIGKPFNPRVVVARVKAVLRRTGALDAEPAAPRVegitfNGWTLDTTRCELSDPQRnTVP 160
Cdd:PRK11083  81 LTARSDEVDRLVGLEIGADDYVAKPFSPREVAARVRTILRRVKKFAAPSPVIRI-----GHFELDEPAARISYFGT-PLT 154

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 505383100 161 LTQGEYGLLLALTQNARRVLSREQLLELTHSESAEVFDRTIDVLIMRLRRKI-EVNPH-QPllIKTIRGLGY 230
Cdd:PRK11083 155 LTRYEFLLLKTLLLSPGRVFSRQQLMDIVWEDAQDSYDRTVDTHIKTLRAKLrAINPDlSP--INTHRGMGY 224
PRK13856 PRK13856
two-component response regulator VirG; Provisional
 5-239 1.54e-44

two-component response regulator VirG; Provisional


Pssm-ID: 172377 [Multi-domain]  Cd Length: 241  Bit Score: 149.58  E-value: 1.54e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100   5 ILVVDDDVAVCELLQDVLSEHVFTVLTCHTGQDaVNRVQQDPGIALVLLDMMLPDINGLQVLLQLQKqRPSLPVVMLTGL 84
Cdd:PRK13856   4 VLVIDDDVAMRHLIVEYLTIHAFKVTAVADSQQ-FNRVLASETVDVVVVDLNLGREDGLEIVRSLAT-KSDVPIIIISGD 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100  85 G-SESDVVVGLEMGADDYIGKPFNprvvvaRVKAVLRRTGALDAEPAAPRVE---GITFNGWTLDTTRCELSDPQRNTVP 160
Cdd:PRK13856  82 RlEEADKVVALELGATDFIAKPFG------TREFLARIRVALRVRPNVVRTKdrrSFCFADWTLNLRQRRLISEAGGEVK 155

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 505383100 161 LTQGEYGLLLALTQNARRVLSREQLLELTHSESAEVFDRTIDVLIMRLRRKIEVNPHQPLLIKTIRGLGYVFATDVSHH 239
Cdd:PRK13856 156 LTAGEFNLLVAFLEKPRDVLSREQLLIASRVREEEVYDRSIDVLILRLRRKLEQDPANPQLIKTARGAGYFFDADVDVS 234
PhoB TIGR02154
phosphate regulon transcriptional regulatory protein PhoB; PhoB is a DNA-binding response ...
 1-232 1.42e-41

phosphate regulon transcriptional regulatory protein PhoB; PhoB is a DNA-binding response regulator protein acting with PhoR in a 2-component system responding to phosphate ion. PhoB acts as a positive regulator of gene expression for phosphate-related genes such as phoA, phoS, phoE and ugpAB as well as itself. It is often found proximal to genes for the high-affinity phosphate ABC transporter (pstSCAB; GenProp0190) and presumably regulates these as well. [Regulatory functions, DNA interactions, Signal transduction, Two-component systems]


Pssm-ID: 131209 [Multi-domain]  Cd Length: 226  Bit Score: 141.31  E-value: 1.42e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100    1 MKPAILVVDDDVAVCELLQDVLSEHVFTVLTCHTGQDAVNRVQqDPGIALVLLDMMLPDINGLQVLLQLQKqRPS---LP 77
Cdd:TIGR02154   1 MTRRILVVEDEPAIRELIAYNLEKAGYDVVEAGDGDEALTLIN-ERGPDLILLDWMLPGTSGIELCRRLRR-RPEtraIP 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100   78 VVMLTGLGSESDVVVGLEMGADDYIGKPFNPRVVVARVKAVLRRTGALDAEpaaprvEGITFNGWTLDTTRCELSDPQRN 157
Cdd:TIGR02154  79 IIMLTARGEEEDRVRGLETGADDYITKPFSPRELLARIKAVLRRIRPQLSD------EVIEVGDLSLDPVAHRVFRGGQP 152

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 505383100  158 tVPLTQGEYGLLLALTQNARRVLSREQLLELTHSESAEVFDRTIDVLIMRLRRKIEVNPHQPlLIKTIRGLGYVF 232
Cdd:TIGR02154 153 -LSLGPTEFRLLHFFMTHPERVYSREQLLDRVWGRDVYVEERTVDVHIRRLRKALNPFGLED-PVQTVRGAGYRF 225
MtrAB_MtrA NF040689
MtrAB system response regulator MtrA;
5-230 2.68e-40

MtrAB system response regulator MtrA;


Pssm-ID: 468653 [Multi-domain]  Cd Length: 219  Bit Score: 138.08  E-value: 2.68e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100   5 ILVVDDDVAVCELLQDVLSEHVFTVLTCHTGQDAV---NRVQQDpgiaLVLLDMMLPDINGLQVLLQLQKqRPSLPVVML 81
Cdd:NF040689   1 ILVVDDDPALAEMLGIVLRAEGFETVFCADGAEAVeafREVRPD----LVLLDLMLPGMDGIEVCRQIRA-ESGVPIIML 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100  82 TGLGSESDVVVGLEMGADDYIGKPFNPRVVVARVKAVLRRTGALDAEPaaprvegITFNGWTLDTTRCELSdpqRN--TV 159
Cdd:NF040689  76 TAKSDTVDVVRGLEAGADDYVVKPFKPKELVARIRARLRRSEDEESEV-------LRIGDLTIDVAGHEVT---RGgeEI 145

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 505383100 160 PLTQGEYGLLLALTQNARRVLSREQLLEL----THSESAevfdRTIDVLIMRLRRKIEVNPHQPLLIKTIRGLGY 230
Cdd:NF040689 146 PLTPLEFDLLVALARKPGQVFSREELLEQvwgyRHAADT----RLVNVHVQRLRAKIERDPENPEIVVTVRGVGY 216
PRK11173 PRK11173
two-component response regulator; Provisional
 3-236 4.36e-39

two-component response regulator; Provisional


Pssm-ID: 183013 [Multi-domain]  Cd Length: 237  Bit Score: 135.53  E-value: 4.36e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100   3 PAILVVDDDVAVCELLQDVLSEHVFTVLTCHTGqDAVNRVQQDPGIALVLLDMMLPDINGLQVLLQLQKQRpSLPVVMLT 82
Cdd:PRK11173   4 PHILIVEDELVTRNTLKSIFEAEGYDVFEATDG-AEMHQILSENDINLVIMDINLPGKNGLLLARELREQA-NVALMFLT 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100  83 GLGSESDVVVGLEMGADDYIGKPFNPRVVVARVKAVLRRTGALDAEPAAPR-VEGITFNGWTLDTTRCELSDPQRNTVPL 161
Cdd:PRK11173  82 GRDNEVDKILGLEIGADDYITKPFNPRELTIRARNLLSRTMNLGTVSEERRsVESYKFNGWELDINSRSLISPDGEQYKL 161

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 505383100 162 TQGEYGLLLALTQNARRVLSREQLL-ELTHSEsAEVFDRTIDVLIMRLRRKIEVNPHQPLLIKTIRGLGYVFATDV 236
Cdd:PRK11173 162 PRSEFRAMLHFCENPGKIQSRAELLkKMTGRE-LKPHDRTVDVTIRRIRKHFESTPDTPEIIATIHGEGYRFCGDL 236
orf27 CHL00148
Ycf27; Reviewed
 2-232 2.60e-38

Ycf27; Reviewed


Pssm-ID: 214376 [Multi-domain]  Cd Length: 240  Bit Score: 133.69  E-value: 2.60e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100   2 KPAILVVDDDVAVCELLQDVLSEHVFTVLTCHTGQDAVNRVQQDpGIALVLLDMMLPDINGLQVLLQLQKqRPSLPVVML 81
Cdd:CHL00148   6 KEKILVVDDEAYIRKILETRLSIIGYEVITASDGEEALKLFRKE-QPDLVILDVMMPKLDGYGVCQEIRK-ESDVPIIML 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100  82 TGLGSESDVVVGLEMGADDYIGKPFNPRVVVARVKAVLRRTGALDAEPAAPRVEGITFNGWTLDTTRCEL-SDPQRntVP 160
Cdd:CHL00148  84 TALGDVSDRITGLELGADDYVVKPFSPKELEARIRSVLRRTNKKSFSSKIPNSSIIRIGFLKIDLNKKQVyKNNER--IR 161

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 505383100 161 LTQGEYGLLLALTQNARRVLSREQLLELT--HSESAEVFDRTIDVLIMRLRRKIEVNPHQPLLIKTIRGLGYVF 232
Cdd:CHL00148 162 LTGMEFSLLELLISKSGEIFSRATILKEVwgYTPERHIDTRVVDVHISRLRAKLEDDPSNPDLILTARGTGYLF 235
PRK10955 PRK10955
envelope stress response regulator transcription factor CpxR;
5-231 1.68e-34

envelope stress response regulator transcription factor CpxR;


Pssm-ID: 182864 [Multi-domain]  Cd Length: 232  Bit Score: 123.37  E-value: 1.68e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100   5 ILVVDDDVAVCELLQDVLSEHVFTVLTCHTGQDAVNRVqqDPGIALVLLDMMLPDINGLQVLLQLQKQRpSLPVVMLTGL 84
Cdd:PRK10955   4 ILLVDDDRELTSLLKELLEMEGFNVIVAHDGEQALDLL--DDSIDLLLLDVMMPKKNGIDTLKELRQTH-QTPVIMLTAR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100  85 GSESDVVVGLEMGADDYIGKPFNPRVVVARVKAVLRRTGALD----AEPAAPRVEgitFNGWTLDTTRCELS-DPQrnTV 159
Cdd:PRK10955  81 GSELDRVLGLELGADDYLPKPFNDRELVARIRAILRRSHWSEqqqnNDNGSPTLE---VDALSLNPGRQEASfDGQ--TL 155

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 505383100 160 PLTQGEYGLLLALTQNARRVLSREQLLELTHSESAEVFDRTIDVLIMRLRRKI-EVNPHQPLLiKTIRGLGYV 231
Cdd:PRK10955 156 ELTGTEFTLLYLLAQHLGQVVSREHLSQEVLGKRLTPFDRAIDMHISNLRRKLpDRKDGHPWF-KTLRGRGYL 227
resp_reg_YycF NF040534
response regulator YycF;
5-230 2.19e-34

response regulator YycF;


Pssm-ID: 439744 [Multi-domain]  Cd Length: 231  Bit Score: 122.91  E-value: 2.19e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100   5 ILVVDDDVAVCELLQDVLSEHVFTVLTCHTGQDAVNRVQQD-PGiaLVLLDMMLPDINGLQVLLQLQKqRPSLPVVMLTG 83
Cdd:NF040534   3 ILVVDDEKPIADILEFNLKKEGYEVFCAYDGNEALELVEEEvPD--LVLLDIMLPGRDGMEVCREVRK-KYDMPIIMLTA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100  84 LGSESDVVVGLEMGADDYIGKPFNPRVVVARVKAVLRRTGALDAEPAAPRVEGITFNGWTLDTTRCELSDpQRNTVPLTQ 163
Cdd:NF040534  80 KDSEIDKVLGLELGADDYVTKPFSTRELIARVKANLRRHQQQNTEEEEEENNEIVIGSLTIHPDAYTVKK-RGETIELTH 158

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 505383100 164 GEYGLLLALTQNARRVLSREQLLELT--HSESAEVfdRTIDVLIMRLRRKIEVNPHQPLLIKTIRGLGY 230
Cdd:NF040534 159 REFELLHYLAKHIGQVMTREHLLQTVwgYDYFGDV--RTVDVTVRRLREKIEDNPSHPEWIVTRRGVGY 225
PRK10161 PRK10161
phosphate response regulator transcription factor PhoB;
1-234 3.74e-32

phosphate response regulator transcription factor PhoB;


Pssm-ID: 182277 [Multi-domain]  Cd Length: 229  Bit Score: 117.13  E-value: 3.74e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100   1 MKPAILVVDDDVAVCELLQDVLSEHVFTVLTCHTGQDAVNRVQQdPGIALVLLDMMLPDINGLQ--VLLQLQKQRPSLPV 78
Cdd:PRK10161   1 MARRILVVEDEAPIREMVCFVLEQNGFQPVEAEDYDSAVNQLNE-PWPDLILLDWMLPGGSGIQfiKHLKRESMTRDIPV 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100  79 VMLTGLGSESDVVVGLEMGADDYIGKPFNPRVVVARVKAVLRRTGALDAEpaaprvEGITFNGWTLDTTRCELSDPQrNT 158
Cdd:PRK10161  80 VMLTARGEEEDRVRGLETGADDYITKPFSPKELVARIKAVMRRISPMAVE------EVIEMQGLSLDPTSHRVMAGE-EP 152

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 505383100 159 VPLTQGEYGLLLALTQNARRVLSREQLLELTHSESAEVFDRTIDVLIMRLRRKIEVNPHQPlLIKTIRGLGYVFAT 234
Cdd:PRK10161 153 LEMGPTEFKLLHFFMTHPERVYSREQLLNHVWGTNVYVEDRTVDVHIRRLRKALEPGGHDR-MVQTVRGTGYRFST 227
PRK10766 PRK10766
two-component system response regulator TorR;
1-227 8.38e-32

two-component system response regulator TorR;


Pssm-ID: 182711 [Multi-domain]  Cd Length: 221  Bit Score: 115.91  E-value: 8.38e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100   1 MKPAILVVDDDVAVCELLQDVLSEHVFTVLTCHTGQDAVNRVQQDPgIALVLLDMMLPDINGLQVLLQLQKqRPSLPVVM 80
Cdd:PRK10766   1 MSYHILVVEDEPVTRARLQGYFEQEGYTVSEAASGAGMREIMQNQH-VDLILLDINLPGEDGLMLTRELRS-RSTVGIIL 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100  81 LTGLGSESDVVVGLEMGADDYIGKPFNPRVVVARVKAVLRRTG-ALDAEPAAPRVEG-ITFNGWTLDTTRCELSdpqRNT 158
Cdd:PRK10766  79 VTGRTDSIDRIVGLEMGADDYVTKPLELRELLVRVKNLLWRISlARQAQPHAQEEDNcYRFAGYCLNVSRRTLE---RNG 155

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 505383100 159 VP--LTQGEYGLLLALTQNARRVLSREQLLELTHSESAEVFDRTIDVLIMRLRRKIEvnphqPLLIKTIRG 227
Cdd:PRK10766 156 EPikLTKAEYELLVAFVTNPGQVLSRERLLRMLSHRVENPNDRTIDVLIRRLRHKLN-----PDLFVTQHG 221
REC_OmpR cd17574
phosphoacceptor receiver (REC) domain of OmpR family response regulators; OmpR-like proteins ...
 6-105 1.31e-31

phosphoacceptor receiver (REC) domain of OmpR family response regulators; OmpR-like proteins are one of the most widespread transcriptional regulators. OmpR family members contain REC and winged helix-turn-helix (wHTH) DNA-binding output effector domain. They are involved in the control of environmental stress tolerance (such as the oxidative, osmotic and acid stress response), motility, virulence, outer membrane biogenesis and other processes. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381116 [Multi-domain]  Cd Length: 99  Bit Score: 111.73  E-value: 1.31e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100   6 LVVDDDVAVCELLQDVLSEHVFTVLTCHTGQDAVNRVQQDPgIALVLLDMMLPDINGLQVLLQLQKQRPSLPVVMLTGLG 85
Cdd:cd17574    1 LVVEDDEEIAELLSDYLEKEGYEVDTAADGEEALELAREEQ-PDLIILDVMLPGMDGFEVCRRLREKGSDIPIIMLTAKD 79

                         90       100
                 ....*....|....*....|
gi 505383100  86 SESDVVVGLEMGADDYIGKP 105
Cdd:cd17574   80 EEEDKVLGLELGADDYITKP 99
PRK10710 PRK10710
DNA-binding transcriptional regulator BaeR; Provisional
 1-238 2.52e-30

DNA-binding transcriptional regulator BaeR; Provisional


Pssm-ID: 182665 [Multi-domain]  Cd Length: 240  Bit Score: 112.86  E-value: 2.52e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100   1 MKPAILVVDDDVAVCELLQDVLSEHVFTVLTCHTGQDAVNRVQQDPGiALVLLDMMLPDINGLQVLLQLQkqRPS-LPVV 79
Cdd:PRK10710   9 NTPRILIVEDEPKLGQLLIDYLQAASYATTLLSHGDEVLPYVRQTPP-DLILLDLMLPGTDGLTLCREIR--RFSdIPIV 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100  80 MLTGLGSESDVVVGLEMGADDYIGKPFNPRVVVARVKAVLRRTGaLDAEPAAPRVEGITfngwTLDTTRCELSDPQRNtV 159
Cdd:PRK10710  86 MVTAKIEEIDRLLGLEIGADDYICKPYSPREVVARVKTILRRCK-PQRELQQQDAESPL----IIDESRFQASWRGKM-L 159

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 505383100 160 PLTQGEYGLLLALTQNARRVLSREQLLELTHSESAEVFDRTIDVLIMRLRRKIEVNPHQPLLIKTIRGLGYVFATDVSH 238
Cdd:PRK10710 160 DLTPAEFRLLKTLSHEPGKVFSREQLLNHLYDDYRVVTDRTIDSHIKNLRRKLESLDAEQSFIRAVYGVGYRWEADACR 238
PRK10701 PRK10701
DNA-binding transcriptional regulator RstA; Provisional
 5-233 2.46e-29

DNA-binding transcriptional regulator RstA; Provisional


Pssm-ID: 236738 [Multi-domain]  Cd Length: 240  Bit Score: 110.11  E-value: 2.46e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100   5 ILVVDDDVAVCELLQDVLSEHVFTVLTCHTG---QDAVNRVQQDpgiaLVLLDMMLPDINGLQVLLQLqkqRPSL--PVV 79
Cdd:PRK10701   4 IVFVEDDAEVGSLIAAYLAKHDIDVTVEPRGdraEATILREQPD----LVLLDIMLPGKDGMTICRDL---RPKWqgPIV 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100  80 MLTGLGSESDVVVGLEMGADDYIGKPFNPRVVVARVKAVLRRTGA-----LDAEPAAPRVEGITFNGWTLDTTRCE--LS 152
Cdd:PRK10701  77 LLTSLDSDMNHILALEMGACDYILKTTPPAVLLARLRLHLRQNEQatqtkGLQETSLTPYKALHFGTLTIDPVNRQvtLA 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100 153 DpqrNTVPLTQGEYGLLLALTQNARRVLSREQLLELTHSESAEVFDRTIDVLIMRLRRKIEVNPHQPLLIKTIRGLGYVF 232
Cdd:PRK10701 157 G---EEISLSTADFDLLWELATHAGQIMDRDALLKNLRGVSYDGLDRSVDVAISRLRKKLLDNAAEPYRIKTVRNKGYLF 233


                 .
gi 505383100 233 A 233
Cdd:PRK10701 234 A 234
cztR_silR_copR TIGR01387
heavy metal response regulator; Members of this family contain a response regulator receiver ...
 5-232 1.28e-28

heavy metal response regulator; Members of this family contain a response regulator receiver domain (pfam00072) and an associated transcriptional regulatory region (pfam00486). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc. Most members encoded by genes adjacent to genes for encoding a member of the heavy metal sensor histidine kinase family (TIGRFAMs:TIGR01386), its partner in the two-component response regulator system. [Regulatory functions, DNA interactions]


Pssm-ID: 130454 [Multi-domain]  Cd Length: 218  Bit Score: 107.58  E-value: 1.28e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100    5 ILVVDDDVAVCELLQDVLSEHVFTVLTCHTGQDAVNRVQQDpGIALVLLDMMLPDINGLQVLLQLQKQRPSLPVVMLTGL 84
Cdd:TIGR01387   1 ILVVEDEQKTAEYLQQGLSESGYVVDAASNGRDGLHLALKD-DYDLIILDVMLPGMDGWQILQTLRRSGKQTPVLFLTAR 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100   85 GSESDVVVGLEMGADDYIGKPFNPRVVVARVKAVLRRTGALDAEPaaprvegITFNGWTLDTTRCELSDPQRNtVPLTQG 164
Cdd:TIGR01387  80 DSVADKVKGLDLGADDYLVKPFSFSELLARVRTLLRRSHSLNSTV-------LEIADLRMDSVRHRVSRGNIR-ITLTRK 151

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 505383100  165 EYGLLLALTQNARRVLSREQLLELTHSESAEVFDRTIDVLIMRLRRKIEvNPHQPLLIKTIRGLGYVF 232
Cdd:TIGR01387 152 EFQLLWLLMRRTGEVLPRTVIASLVWGMNFDSDTNVVDVAIRRLRAKVD-DPFEEKLIHTIRGMGYVL 218
REC_OmpR_CpxR cd17623
phosphoacceptor receiver (REC) domain of CpxR-like OmpR family response regulators; CpxR is ...
 5-121 2.66e-28

phosphoacceptor receiver (REC) domain of CpxR-like OmpR family response regulators; CpxR is part of the CpxA/CpxR two-component regulatory system that mediates envelope stress responses that is key for virulence and antibiotic resistance in several Gram negative pathogens. CpxR is a transcription factor/response regulator that controls the expression of numerous genes, including those of the classical porins OmpF and OmpC. It belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381138 [Multi-domain]  Cd Length: 115  Bit Score: 103.92  E-value: 2.66e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100   5 ILVVDDDVAVCELLQDVLSEHVFTVLTCHTGQDAVNRVQQDpGIALVLLDMMLPDINGLQVLLQLQKqRPSLPVVMLTGL 84
Cdd:cd17623    1 ILLIDDDRELTELLTEYLEMEGFNVRAAHDGEQGLAALLEG-SPDLVVLDVMLPKMNGLDVLKELRK-TSQVPVLMLTAR 78

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 505383100  85 GSESDVVVGLEMGADDYIGKPFNPRVVVARVKAVLRR 121
Cdd:cd17623   79 GDDIDRILGLELGADDYLPKPFNPRELVARIRAILRR 115
trans_reg_C cd00383
DNA-binding effector domain of two-component system response regulators; Bacteria and some ...
 142-232 1.94e-27

DNA-binding effector domain of two-component system response regulators; Bacteria and some eukaryotes use two-component signal transduction systems to detect and respond to changes in the environment. The systems consists of a sensor histidine kinase and a response regulator. The former autophosphorylates a histidine residue on detecting an external stimulus. The phosphate is then transferred to an invariant aspartate residue in a highly conserved receiver domain of the response regulator. Phosphorylation activates a variable effector domain of the response regulator, which triggers the cellular response. This C-terminal effector domain belongs to the winged helix-turn-helix family of transcriptional regulators and contains DNA and RNA polymerase binding sites. Several dimers or monomers bind head to tail to small tandem repeats upstream of the genes. The RNA polymerase binding sites interact with the alpha or sigma subunit of RNA polymerase.


Pssm-ID: 294013 [Multi-domain]  Cd Length: 89  Bit Score: 100.63  E-value: 1.94e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100 142 WTLDTTRCELSDPQRnTVPLTQGEYGLLLALTQNARRVLSREQLLELTHSESAEVFDRTIDVLIMRLRRKIEVNPHqPLL 221
Cdd:cd00383    1 LRLDPARREVTVDGE-EVELTPKEFELLELLARNPGRVVSREELLEAVWGYDYEVDDRTVDVHISRLRKKLEDDPE-PRL 78

                         90
                 ....*....|.
gi 505383100 222 IKTIRGLGYVF 232
Cdd:cd00383   79 IKTVRGVGYRL 89
Trans_reg_C pfam00486
Transcriptional regulatory protein, C terminal;
157-232 1.58e-26

Transcriptional regulatory protein, C terminal;


Pssm-ID: 425712 [Multi-domain]  Cd Length: 77  Bit Score: 97.97  E-value: 1.58e-26
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 505383100  157 NTVPLTQGEYGLLLALTQNARRVLSREQLLELTHSESAEVFDRTIDVLIMRLRRKIEVNPHQPLLIKTIRGLGYVF 232
Cdd:pfam00486   2 EEVELTPKEFKLLELLAENPGRVVSREQLLEEVWGEDYDVDDNTVDVHISRLRKKLEDDPRDPRLIKTVRGVGYRL 77
AtoC COG2204
DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, ...
 1-108 2.20e-26

DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, and a Fis-type DNA-binding domains [Signal transduction mechanisms];


Pssm-ID: 441806 [Multi-domain]  Cd Length: 418  Bit Score: 105.43  E-value: 2.20e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100   1 MKPAILVVDDDVAVCELLQDVLSEHVFTVLTCHTGQDAVNRVQQDPgIALVLLDMMLPDINGLQVLLQLQKQRPSLPVVM 80
Cdd:COG2204    1 SMARILVVDDDPDIRRLLKELLERAGYEVETAASGEEALALLREEP-PDLVLLDLRMPGMDGLELLRELRALDPDLPVIL 79

                         90       100
                 ....*....|....*....|....*...
gi 505383100  81 LTGLGSESDVVVGLEMGADDYIGKPFNP 108
Cdd:COG2204   80 LTGYGDVETAVEAIKAGAFDYLTKPFDL 107
REC_OmpR_BsPhoP-like cd19937
phosphoacceptor receiver (REC) domain of BsPhoP-like OmpR family response regulators; Bacillus ...
 6-108 8.93e-26

phosphoacceptor receiver (REC) domain of BsPhoP-like OmpR family response regulators; Bacillus subtilis PhoP (BsPhoP) is part of the PhoPR two-component system that participates in a signal transduction network that controls adaptation of the bacteria to phosphate deficiency by regulating (activating or repressing) genes of the Pho regulon upon phosphorylation by PhoR. When activated, PhoPR directs expression of phosphate scavenging enzymes, lowers synthesis of the phosphate-rich wall teichoic acid (WTA) and initiates synthesis of teichuronic acid, a non-phosphate containing replacement anionic polymer. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381164 [Multi-domain]  Cd Length: 116  Bit Score: 97.34  E-value: 8.93e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100   6 LVVDDDVAVCELLQDVLSEHVFTVLTCHTGQDAVNRVQQDPgIALVLLDMMLPDINGLQV--LLQLQKQRPSLPVVMLTG 83
Cdd:cd19937    1 LVVDDEEDIVELLKYNLEKEGYEVVTAYDGEEALKRAKDEK-PDLIILDLMLPGIDGLEVcrILRSDPKTSSIPIIMLTA 79

                         90       100
                 ....*....|....*....|....*
gi 505383100  84 LGSESDVVVGLEMGADDYIGKPFNP 108
Cdd:cd19937   80 KGEEFDKVLGLELGADDYITKPFSP 104
PleD COG3706
Two-component response regulator, PleD family, consists of two REC domains and a diguanylate ...
 2-108 1.46e-25

Two-component response regulator, PleD family, consists of two REC domains and a diguanylate cyclase (GGDEF) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 442920 [Multi-domain]  Cd Length: 179  Bit Score: 98.44  E-value: 1.46e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100   2 KPAILVVDDDVAVCELLQDVLSEHVFTVLTCHTGQDAVNRVQQDPgIALVLLDMMLPDINGLQVLLQ--LQKQRPSLPVV 79
Cdd:COG3706    1 PARILVVDDDPTNRKLLRRLLEAAGYEVVEAADGEEALELLQEHR-PDLILLDLEMPDMDGLELCRRlrADPRTADIPII 79

                         90       100
                 ....*....|....*....|....*....
gi 505383100  80 MLTGLGSESDVVVGLEMGADDYIGKPFNP 108
Cdd:COG3706   80 FLTALDDEEDRARALEAGADDYLTKPFDP 108
CheY COG0784
CheY-like REC (receiver) domain, includes chemotaxis protein CheY and sporulation regulator ...
 5-108 2.32e-24

CheY-like REC (receiver) domain, includes chemotaxis protein CheY and sporulation regulator Spo0F [Signal transduction mechanisms];


Pssm-ID: 440547 [Multi-domain]  Cd Length: 128  Bit Score: 93.76  E-value: 2.32e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100   5 ILVVDDDVAVCELLQDVLSEHVFTVLTCHTGQDAVNRVQQDPgIALVLLDMMLPDINGLQVLLQ--LQKQRPSLPVVMLT 82
Cdd:COG0784    8 ILVVDDNPDNRELLRRLLERLGYEVTTAEDGAEALELLRAGP-PDLILLDINMPGMDGLELLRRirALPRLPDIPIIALT 86

                         90       100
                 ....*....|....*....|....*.
gi 505383100  83 GLGSESDVVVGLEMGADDYIGKPFNP 108
Cdd:COG0784   87 AYADEEDRERALEAGADDYLTKPVDP 112
RpfG COG3437
Response regulator c-di-GMP phosphodiesterase, RpfG family, contains REC and HD-GYP domains ...
 1-108 9.20e-24

Response regulator c-di-GMP phosphodiesterase, RpfG family, contains REC and HD-GYP domains [Signal transduction mechanisms];


Pssm-ID: 442663 [Multi-domain]  Cd Length: 224  Bit Score: 95.23  E-value: 9.20e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100   1 MKPAILVVDDDVAVCELLQDVLSEHVFTVLTCHTGQDAVNRVQQDPgIALVLLDMMLPDINGLQ--VLLQLQKQRPSLPV 78
Cdd:COG3437    5 QAPTVLIVDDDPENLELLRQLLRTLGYDVVTAESGEEALELLLEAP-PDLILLDVRMPGMDGFEllRLLRADPSTRDIPV 83

                         90       100       110
                 ....*....|....*....|....*....|
gi 505383100  79 VMLTGLGSESDVVVGLEMGADDYIGKPFNP 108
Cdd:COG3437   84 IFLTALADPEDRERALEAGADDYLTKPFDP 113
REC cd00156
phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response ...
 6-105 1.14e-23

phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response regulators (PRRs); Two-component systems (TCSs) involving a sensor and a response regulator are used by bacteria to adapt to changing environments. Processes regulated by two-component systems in bacteria include sporulation, pathogenicity, virulence, chemotaxis, and membrane transport. Response regulators (RRs) share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. Response regulators regulate transcription, post-transcription or post-translation, or have functions such as methylesterases, adenylate or diguanylate cyclase, c-di-GMP-specific phosphodiesterases, histidine kinases, serine/threonine protein kinases, and protein phosphatases, depending on their output domains. The function of some output domains are still unknown. TCSs are found in all three domains of life - bacteria, archaea, and eukaryotes, however, the presence and abundance of particular RRs vary between the lineages. Archaea encode very few RRs with DNA-binding output domains; most are stand-alone REC domains. Among eukaryotes, TCSs are found primarily in protozoa, fungi, algae, and green plants. REC domains function as phosphorylation-mediated switches within RRs, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381085 [Multi-domain]  Cd Length: 99  Bit Score: 91.13  E-value: 1.14e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100   6 LVVDDDVAVCELLQDVLSEHVFTVLTCHTGQDAVNRVQQDPgIALVLLDMMLPDINGLQVLLQLQKQRPSLPVVMLTGLG 85
Cdd:cd00156    1 LIVDDDPAIRELLKSLLEREGYEVDTAADGEEALELLREER-PDLVLLDLMMPGMDGLELLRKLRELPPDIPVIVLTAKA 79

                         90       100
                 ....*....|....*....|
gi 505383100  86 SESDVVVGLEMGADDYIGKP 105
Cdd:cd00156   80 DEEDAVRALELGADDYLVKP 99
PRK09836 PRK09836
DNA-binding transcriptional activator CusR; Provisional
 5-232 2.81e-23

DNA-binding transcriptional activator CusR; Provisional


Pssm-ID: 182102 [Multi-domain]  Cd Length: 227  Bit Score: 93.84  E-value: 2.81e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100   5 ILVVDDDVAVCELLQDVLSEHVFTVLTCHTGQDAVNrVQQDPGIALVLLDMMLPDINGLQVLLQLQKQRPSLPVVMLTGL 84
Cdd:PRK09836   3 LLIVEDEKKTGEYLTKGLTEAGFVVDLADNGLNGYH-LAMTGDYDLIILDIMLPDVNGWDIVRMLRSANKGMPILLLTAL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100  85 GSESDVVVGLEMGADDYIGKPFNPRVVVARVKAVLRRTGALDAEpAAPRVEGITFNGWTLDTTRcelsdpQRNTVPLTQG 164
Cdd:PRK09836  82 GTIEHRVKGLELGADDYLVKPFAFAELLARVRTLLRRGAAVIIE-SQFQVADLMVDLVSRKVTR------SGTRITLTSK 154

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 505383100 165 EYGLLLALTQNARRVLSREQLLELTHSESAEVFDRTIDVLIMRLRRKIEvNPHQPLLIKTIRGLGYVF 232
Cdd:PRK09836 155 EFTLLEFFLRHQGEVLPRSLIASQVWDMNFDSDTNAIDVAVKRLRGKID-NDFEPKLIQTVRGVGYML 221
Trans_reg_C smart00862
Transcriptional regulatory protein, C terminal; This domain is almost always found associated ...
 158-232 3.21e-23

Transcriptional regulatory protein, C terminal; This domain is almost always found associated with the response regulator receiver domain. It may play a role in DNA binding.


Pssm-ID: 214866 [Multi-domain]  Cd Length: 76  Bit Score: 89.15  E-value: 3.21e-23
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 505383100   158 TVPLTQGEYGLLLALTQNARRVLSREQLLELTHSESAEVFDRTIDVLIMRLRRKIEVNPHqPLLIKTIRGLGYVF 232
Cdd:smart00862   3 PIKLTPKEFRLLELLLRNPGRVVSREELLEAVWGDDEDVDDNTLDVHISRLRKKLEDDGD-PRLIETVRGVGYRL 76
Response_reg pfam00072
Response regulator receiver domain; This domain receives the signal from the sensor partner in ...
 5-108 2.36e-21

Response regulator receiver domain; This domain receives the signal from the sensor partner in bacterial two-component systems. It is usually found N-terminal to a DNA binding effector domain.


Pssm-ID: 395025 [Multi-domain]  Cd Length: 111  Bit Score: 85.67  E-value: 2.36e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100    5 ILVVDDDVAVCELLQDVLSEHVFTVLTCHTGQDAVNRVQQDPgIALVLLDMMLPDINGLQVLLQLQKQRPSLPVVMLTGL 84
Cdd:pfam00072   1 VLIVDDDPLIRELLRQLLEKEGYVVAEADDGKEALELLKEER-PDLILLDINMPGMDGLELLKRIRRRDPTTPVIILTAH 79

                          90       100
                  ....*....|....*....|....
gi 505383100   85 GSESDVVVGLEMGADDYIGKPFNP 108
Cdd:pfam00072  80 GDEDDAVEALEAGADDFLSKPFDP 103
PRK11517 PRK11517
DNA-binding response regulator HprR;
5-235 2.70e-21

DNA-binding response regulator HprR;


Pssm-ID: 183172 [Multi-domain]  Cd Length: 223  Bit Score: 88.42  E-value: 2.70e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100   5 ILVVDDDVAVCELLQDVLSEHVFTVLTCHTGQDAVNRVQQDpGIALVLLDMMLPDINGLQVLLQLQKQRPSlPVVMLTGL 84
Cdd:PRK11517   3 ILLIEDNQRTQEWVTQGLSEAGYVIDAVSDGRDGLYLALKD-DYALIILDIMLPGMDGWQILQTLRTAKQT-PVICLTAR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100  85 GSESDVVVGLEMGADDYIGKPFNPRVVVARVKAVLRRTGALDAEpaaprvegITFNGWTLDTTRCELSdpqRNTVP--LT 162
Cdd:PRK11517  81 DSVDDRVRGLDSGANDYLVKPFSFSELLARVRAQLRQHHALNST--------LEISGLRMDSVSQSVS---RDNISitLT 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100 163 QGEYGLLLALTQNARRVLSREQLlelthseSAEV----FD---RTIDVLIMRLRRKIEvNPHQPLLIKTIRGLGYVFATD 235
Cdd:PRK11517 150 RKEFQLLWLLASRAGEIIPRTVI-------ASEIwginFDsdtNTVDVAIRRLRAKVD-DPFPEKLIATIRGMGYSFVAV 221
REC_D1_PleD-like cd17538
first (D1) phosphoacceptor receiver (REC) domain of response regulator PleD and similar ...
 5-106 6.35e-21

first (D1) phosphoacceptor receiver (REC) domain of response regulator PleD and similar domains; PleD contains a REC domain (D1) with the phosphorylatable aspartate, a REC-like adaptor domain (D2), and the enzymatic diguanylate cyclase (DGC) domain, also called the GGDEF domain according to a conserved sequence motif, as its output domain. The GGDEF-containing PleD response regulators are global regulators of cell metabolism in some important human pathogens. This model describes D1 of PleD and similar domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381093 [Multi-domain]  Cd Length: 104  Bit Score: 84.09  E-value: 6.35e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100   5 ILVVDDDVAVCELLQDVLSEHVFTVLTCHTGQDAVNRVQQDPgIALVLLDMMLPDING--LQVLLQLQKQRPSLPVVMLT 82
Cdd:cd17538    2 ILVVDDEPANRELLEALLSAEGYEVLTADSGQEALALAEEEL-PDLILLDVMMPGMDGfeVCRRLKEDPETRHIPVIMIT 80

                         90       100
                 ....*....|....*....|....
gi 505383100  83 GLGSESDVVVGLEMGADDYIGKPF 106
Cdd:cd17538   81 ALDDREDRIRGLEAGADDFLSKPI 104
REC_OmpR_MtrA-like cd17626
phosphoacceptor receiver (REC) domain of MtrA-like OmpR family response regulators; MtrA is ...
 5-108 1.71e-20

phosphoacceptor receiver (REC) domain of MtrA-like OmpR family response regulators; MtrA is part of MtrA/MtrB (or MtrAB), a highly conserved two-component system (TCS) implicated in the regulation of cell division in the actinobacteria. In unicellular Mycobacterium tuberculosis, MtrAB coordinates DNA replication with cell division and regulates the transcription of resuscitation-promoting factor B. In filamentous Streptomyces venezuelae, it links antibiotic production to sporulation. MtrA belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381141 [Multi-domain]  Cd Length: 115  Bit Score: 83.29  E-value: 1.71e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100   5 ILVVDDDVAVCELLQDVLSEHVFTVLTCHTGQDAVNRVQQDpGIALVLLDMMLPDINGLQVLLQLQKQRpSLPVVMLTGL 84
Cdd:cd17626    3 ILVVDDDAALAEMIGIVLRGEGFDPAFCGDGTQALAAFREV-RPDLVLLDLMLPGIDGIEVCRQIRAES-GVPIVMLTAK 80

                         90       100
                 ....*....|....*....|....
gi 505383100  85 GSESDVVVGLEMGADDYIGKPFNP 108
Cdd:cd17626   81 SDTVDVVLGLESGADDYVAKPFKP 104
REC_OmpR_YycF-like cd17614
phosphoacceptor receiver (REC) domain of YrcF-like OmpR family response regulators; YycF ...
 5-121 1.41e-19

phosphoacceptor receiver (REC) domain of YrcF-like OmpR family response regulators; YycF appears to play an important role in cell wall integrity in a wide range of gram-positive bacteria, and may also modulate cell membrane integrity. It functions as part of a phosphotransfer system that ultimately controls the levels of competence within the bacteria. YycF belongs to the OmpR family of response regulators, which are characterized by a REC domain and a winged helix-turn-helix effector domain involved in DNA binding. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381130 [Multi-domain]  Cd Length: 115  Bit Score: 80.93  E-value: 1.41e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100   5 ILVVDDDVAVCELLQDVLSEHVFTVLTCHTGQDAVNRVQQ-DPGiaLVLLDMMLPDINGLQVLLQLQKqRPSLPVVMLTG 83
Cdd:cd17614    1 ILVVDDEKPISDILKFNLTKEGYEVVTAYDGREALEKVEEeQPD--LILLDLMLPEKDGLEVCREVRK-TSNVPIIMLTA 77

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 505383100  84 LGSESDVVVGLEMGADDYIGKPFNPRVVVARVKAVLRR 121
Cdd:cd17614   78 KDSEVDKVLGLELGADDYVTKPFSNRELLARVKANLRR 115
REC_OmpR_kpRstA-like cd17622
phosphoacceptor receiver (REC) domain of kpRstA-like OmpR family response regulators; ...
 5-108 2.19e-19

phosphoacceptor receiver (REC) domain of kpRstA-like OmpR family response regulators; Klebsiella pneumoniae RstA (kpRstA) is part of the RstA/RstB two-component regulatory system that may play a regulatory role in virulence. It belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381137 [Multi-domain]  Cd Length: 116  Bit Score: 80.50  E-value: 2.19e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100   5 ILVVDDDVAVCELLQDVLSEHVFTVLTCHTGQDAVNRVQQ-DPgiALVLLDMMLPDINGLQVLLQLqkqRP--SLPVVML 81
Cdd:cd17622    3 ILLVEDDPKLARLIADFLESHGFNVVVEHRGDRALEVIAReKP--DAVLLDIMLPGIDGLTLCRDL---RPkyQGPILLL 77

                         90       100
                 ....*....|....*....|....*..
gi 505383100  82 TGLGSESDVVVGLEMGADDYIGKPFNP 108
Cdd:cd17622   78 TALDSDIDHILGLELGADDYVVKPVEP 104
REC_OmpR_PhoB cd17618
phosphoacceptor receiver (REC) domain of PhoB response regulator from the OmpR family; The ...
 5-108 2.83e-19

phosphoacceptor receiver (REC) domain of PhoB response regulator from the OmpR family; The transcription factor PhoB is a component of the PhoR/PhoB two-component system, a key regulatory protein network that facilitates response to inorganic phosphate (Pi) starvation conditions by turning on the phosphate (pho) regulon whose products are involved in phosphorus uptake and metabolism. PhoB is a member of the OmpR family of DNA-binding response regulators that contains REC and winged helix-turn-helix (wHTH) DNA-binding output effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381133 [Multi-domain]  Cd Length: 118  Bit Score: 80.37  E-value: 2.83e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100   5 ILVVDDDVAVCELLQDVLSEHVFTVLTCHTGQDAVNRVQqDPGIALVLLDMMLPDINGLQVLLQ--LQKQRPSLPVVMLT 82
Cdd:cd17618    3 ILIVEDEPAIREMIAFNLERAGFDVVEAEDAESAVNLIV-EPRPDLILLDWMLPGGSGIQFIRRlkRDEMTRDIPIIMLT 81

                         90       100
                 ....*....|....*....|....*.
gi 505383100  83 GLGSESDVVVGLEMGADDYIGKPFNP 108
Cdd:cd17618   82 ARGEEEDKVRGLEAGADDYITKPFSP 107
REC_OmpR_DrrD-like cd17625
phosphoacceptor receiver (REC) domain of DrrD-like OmpR family response regulators; DrrD is a ...
 6-106 3.12e-19

phosphoacceptor receiver (REC) domain of DrrD-like OmpR family response regulators; DrrD is a OmpR/PhoB homolog from Thermotoga maritima whose function is not yet known. This subfamily also includes Streptococcus agalactiae transcriptional regulatory protein DltR, part of the DltS/DltR two-component system (TCS), and Pseudomonas aeruginosa transcriptional activator protein PfeR, part of the PfeR/PfeS TCS, which activates expression of the ferric enterobactin receptor. The DltS/DltR TCS regulates the expression of the dlt operon, which comprises four genes (dltA, dltB, dltC, and dltD) that catalyze the incorporation of D-alanine residues into the lipoteichoic acids. Members of this subfamily belong to the OmpR/PhoB family, which comprises of two domains, an N-terminal receiver domain and a C-terminal DNA-binding winged helix-turn-helix effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381140 [Multi-domain]  Cd Length: 115  Bit Score: 79.96  E-value: 3.12e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100   6 LVVDDDVAVCELLQDVLSEHVFTVLTCHTGQDAVNRVQQDPgIALVLLDMMLPDINGLQVLLQLQKQRPSLPVVMLTGLG 85
Cdd:cd17625    1 LVVEDEKDLSEAITKHLKKEGYTVDVCFDGEEGLEYALSGI-YDLIILDIMLPGMDGLEVLKSLREEGIETPVLLLTALD 79

                         90       100
                 ....*....|....*....|.
gi 505383100  86 SESDVVVGLEMGADDYIGKPF 106
Cdd:cd17625   80 AVEDRVKGLDLGADDYLPKPF 100
PRK10816 PRK10816
two-component system response regulator PhoP;
43-232 6.17e-19

two-component system response regulator PhoP;


Pssm-ID: 182755 [Multi-domain]  Cd Length: 223  Bit Score: 82.09  E-value: 6.17e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100  43 QQDPGIALVllDMMLPDINGLQVLLQLQKQRPSLPVVMLTGLGSESDVVVGLEMGADDYIGKPFNPRVVVARVKAVLRRT 122
Cdd:PRK10816  42 EHLPDIAIV--DLGLPDEDGLSLIRRWRSNDVSLPILVLTARESWQDKVEVLSAGADDYVTKPFHIEEVMARMQALMRRN 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100 123 GALdaepaAPRVegITFNGWTLDTTRCELSDPQRNtVPLTQGEYGLLLALTQNARRVLSREQLLELTHSESAEVFDRTID 202
Cdd:PRK10816 120 SGL-----ASQV--ISLPPFQVDLSRRELSINDEV-IKLTAFEYTIMETLIRNNGKVVSKDSLMLQLYPDAELRESHTID 191

                        170       180       190
                 ....*....|....*....|....*....|
gi 505383100 203 VLIMRLRRKIEvNPHQPLLIKTIRGLGYVF 232
Cdd:PRK10816 192 VLMGRLRKKIQ-AQYPQEVITTVRGQGYRF 220
REC_OmpR_CusR-like cd19935
phosphoacceptor receiver (REC) domain of CusR-like OmpR family response regulators; ...
 5-105 1.12e-18

phosphoacceptor receiver (REC) domain of CusR-like OmpR family response regulators; Escherichia coli CusR is part of the CusS/CusR two-component system (TCS) that is involved in response to copper and silver. Other members of this subfamily include Escherichia coli PcoR, Pseudomonas syringae CopR, and Streptomyces coelicolor CutR, which are all transcriptional regulatory proteins and components of TCSs that regulate genes involved in copper resistance and/or metabolism. member of the subfamily is Escherichia coli HprR (hydrogen peroxide response regulator), previously called YdeW, which is part of the HprSR (or YedVW) TCS involved in stress response to hydrogen peroxide, as well as Cupriavidus metallidurans CzcR, which is part of the CzcS/CzcR TCS involved in the control of cobalt, zinc, and cadmium homeostasis. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381162 [Multi-domain]  Cd Length: 100  Bit Score: 78.25  E-value: 1.12e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100   5 ILVVDDDVAVCELLQDVLSEHVFTVLTCHTGQDAVNRVQQDPgIALVLLDMMLPDINGLQVLLQLQKQRPSLPVVMLTGL 84
Cdd:cd19935    1 ILVVEDEKKLAEYLKKGLTEEGYAVDVAYDGEDGLHLALTNE-YDLIILDVMLPGLDGLEVLRRLRAAGKQTPVLMLTAR 79

                         90       100
                 ....*....|....*....|.
gi 505383100  85 GSESDVVVGLEMGADDYIGKP 105
Cdd:cd19935   80 DSVEDRVKGLDLGADDYLVKP 100
REC_OmpR_BfmR-like cd19939
phosphoacceptor receiver (REC) domain of BfmR-like OmpR family response regulators; ...
 5-121 1.18e-18

phosphoacceptor receiver (REC) domain of BfmR-like OmpR family response regulators; Acinetobacter baumannii BfmR is part of the BfmR/S two-component system that functions as the master regulator of biofilm initiation. BfmR confers resistance to complement-mediated bactericidal activity, independent of capsular polysaccharide, and also increases resistance to the clinically important antimicrobials meropenem and colistin, making it a potential antimicrobial target. Its inhibition would have the dual benefit of significantly decreasing in vivo survival and increasing sensitivity to selected antimicrobials. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381166 [Multi-domain]  Cd Length: 116  Bit Score: 78.57  E-value: 1.18e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100   5 ILVVDDDVAVCELLQDVLSEHVFTVLTCHTGQDAVNRVQQDPGiALVLLDMMLPDINGLQVLLQLQKqRPSLPVVMLTGL 84
Cdd:cd19939    2 ILIVEDELELARLTRDYLIKAGLEVSVFTDGQRAVRRIIDEQP-SLVVLDIMLPGMDGLTVCREVRE-HSHVPILMLTAR 79

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 505383100  85 GSESDVVVGLEMGADDYIGKPFNPRVVVARVKAVLRR 121
Cdd:cd19939   80 TEEMDRVLGLEMGADDYLCKPFSPRELLARVRALLRR 116
CitB COG4565
DNA-binding response regulator DpiB of citrate/malate metabolism [Transcription, Signal ...
 1-108 1.28e-18

DNA-binding response regulator DpiB of citrate/malate metabolism [Transcription, Signal transduction mechanisms];


Pssm-ID: 443622 [Multi-domain]  Cd Length: 138  Bit Score: 79.24  E-value: 1.28e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100   1 MKPAILVVDDDVAVCELLQDVLSEH--VFTVLTCHTGQDAVNRVQQDPgIALVLLDMMLPDINGLQVLLQLQKQRPSLPV 78
Cdd:COG4565    2 KMIRVLIVEDDPMVAELLRRYLERLpgFEVVGVASSGEEALALLAEHR-PDLILLDIYLPDGDGLELLRELRARGPDVDV 80

                         90       100       110
                 ....*....|....*....|....*....|
gi 505383100  79 VMLTGLGSESDVVVGLEMGADDYIGKPFNP 108
Cdd:COG4565   81 IVITAARDPETVREALRAGVVDYLIKPFTF 110
PRK15479 PRK15479
transcriptional regulator TctD;
5-231 1.89e-18

transcriptional regulator TctD;


Pssm-ID: 185376 [Multi-domain]  Cd Length: 221  Bit Score: 80.92  E-value: 1.89e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100   5 ILVVDDDVAVCELLQDVLSEHVFTVLTCHTGQdAVNRVQQDPGIALVLLDMMLPDINGLQVLLQLQKQRPSLPVVMLTGL 84
Cdd:PRK15479   3 LLLAEDNRELAHWLEKALVQNGFAVDCVFDGL-AADHLLQSEMYALAVLDINMPGMDGLEVLQRLRKRGQTLPVLLLTAR 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100  85 GSESDVVVGLEMGADDYIGKPFNPRVVVARVKAVLRRTGALDAEpaAPRVEGITFNgwtlDTTRCELSDpqrNTVPLTQG 164
Cdd:PRK15479  82 SAVADRVKGLNVGADDYLPKPFELEELDARLRALLRRSAGQVQE--VQQLGELIFH----DEGYFLLQG---QPLALTPR 152

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 505383100 165 EYGLLLALTQNARRVLSREQLLELTHSESAEVFDRTIDVLIMRLRRKIEvnpHQPLLIKTIRGLGYV 231
Cdd:PRK15479 153 EQALLTVLMYRRTRPVSRQQLFEQVFSLNDEVSPESIELYIHRLRKKLQ---GSDVRITTLRGLGYV 216
REC_OmpR_MtPhoP-like cd17615
phosphoacceptor receiver (REC) domain of MtPhoP-like OmpR family response regulators; ...
 5-122 2.61e-18

phosphoacceptor receiver (REC) domain of MtPhoP-like OmpR family response regulators; Mycobacterium tuberculosis PhoP (MtPhoP) is part of the PhoP/PhoR two-component system that is involved in phosphate control by stimulating expression of genes involved in scavenging, transport and mobilization of phosphate, and repressing the utilization of nitrogen sources. Also included in this subfamily is Mycobacterium tuberculosis transcriptional regulatory protein TcrX, part of the two-component regulatory system TcrY/TcrX that may be involved in virulence. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381131 [Multi-domain]  Cd Length: 118  Bit Score: 77.78  E-value: 2.61e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100   5 ILVVDDDVAVCELLQDVLSEHVFTVLTCHTGQDAVnRVQQDPGIALVLLDMMLPDINGLQVLLQLQKQRPSLPVVMLTGL 84
Cdd:cd17615    2 VLVVDDEPNITELLSMALRYEGWDVETAADGAEAL-AAAREFRPDAVVLDIMLPDMDGLEVLRRLRADGPDVPVLFLTAK 80

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 505383100  85 GSESDVVVGLEMGADDYIGKPFNPRVVVARVKAVLRRT 122
Cdd:cd17615   81 DSVEDRIAGLTAGGDDYVTKPFSLEEVVARLRALLRRS 118
REC_NtrX-like cd17550
phosphoacceptor receiver (REC) domain of nitrogen assimilation regulatory protein NtrX and ...
 5-107 4.34e-18

phosphoacceptor receiver (REC) domain of nitrogen assimilation regulatory protein NtrX and similar proteins; NtrX is part of the two-component regulatory system NtrY/NtrX that is involved in the activation of nitrogen assimilatory genes such as Gln. It is phosphorylated by the histidine kinase NtrY and interacts with sigma-54. NtrX is a member of the NtrC family, characterized by a domain architecture containing an N-terminal REC domain, followed by a central sigma-54 interaction/ATPase domain, and a C-terminal DNA binding domain. NtrC family response regulators are sigma54-dependent transcriptional activators. Also included in this subfamily is Aquifex aeolicus NtrC4. The ability of the central domain to hydrolyze ATP and thus to interact effectively with a complex of RNA polymerase, sigma54, and promoter, is controlled by the phosphorylation status of the REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381102 [Multi-domain]  Cd Length: 115  Bit Score: 77.15  E-value: 4.34e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100   5 ILVVDDDVAVCELLQDVLSEHVFTVLTCHTGQDAVNRVQQDPgIALVLLDMMLPDINGLQVLLQLQKQRPSLPVVMLTGL 84
Cdd:cd17550    1 ILIVDDEEDIRESLSGILEDEGYEVDTAADGEEALKLIKERR-PDLVLLDIWLPDMDGLELLKEIKEKYPDLPVIMISGH 79

                         90       100
                 ....*....|....*....|...
gi 505383100  85 GSESDVVVGLEMGADDYIGKPFN 107
Cdd:cd17550   80 GTIETAVKATKLGAYDFIEKPLS 102
COG4567 COG4567
DNA-binding response regulator, ActR/RegA family, consists of REC and Fis-type HTH domains ...
 3-108 5.66e-18

DNA-binding response regulator, ActR/RegA family, consists of REC and Fis-type HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443624 [Multi-domain]  Cd Length: 177  Bit Score: 78.42  E-value: 5.66e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100   3 PAILVVDDDVAVCELLQDVLSEHVFTVLTCHTGQDAVNRVQQDPgIALVLLDMMLPDINGLQVLLQLQKQRPSLPVVMLT 82
Cdd:COG4567    5 RSLLLVDDDEAFARVLARALERRGFEVTTAASVEEALALLEQAP-PDYAVLDLRLGDGSGLDLIEALRERDPDARIVVLT 83

                         90       100
                 ....*....|....*....|....*.
gi 505383100  83 GLGSESDVVVGLEMGADDYIGKPFNP 108
Cdd:COG4567   84 GYASIATAVEAIKLGADDYLAKPADA 109
REC_OmpR_BaeR-like cd19938
phosphoacceptor receiver (REC) domain of BaeR-like OmpR family response regulators; BaeR is ...
 5-108 5.76e-18

phosphoacceptor receiver (REC) domain of BaeR-like OmpR family response regulators; BaeR is part of the BaeSR two-component system that is involved in regulating genes that confer multidrug and metal resistance. In Salmonella, BaeSR induces AcrD and MdtABC drug efflux systems, increasing multidrug and metal resistance. In Escherichia coli, BaeR stimulates multidrug resistance via mdtABC (multidrug transporter ABC, formerly known as yegMNO) genes, which encode a resistance-nodulation-cell division (RND) drug efflux system. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381165 [Multi-domain]  Cd Length: 114  Bit Score: 76.65  E-value: 5.76e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100   5 ILVVDDDVAVCELLQDVLSEHVFTVLTCHTGQDAVNRVQQDPGiALVLLDMMLPDINGLQVLLQLQKQrPSLPVVMLTGL 84
Cdd:cd19938    2 ILIVEDEPKLAQLLIDYLRAAGYAPTLLAHGDQVLPYVRHTPP-DLILLDLMLPGTDGLTLCREIRRF-SDVPIIMVTAR 79

                         90       100
                 ....*....|....*....|....
gi 505383100  85 GSESDVVVGLEMGADDYIGKPFNP 108
Cdd:cd19938   80 VEEIDRLLGLELGADDYICKPYSP 103
REC_OmpR_ArcA_TorR-like cd17619
phosphoacceptor receiver (REC) domain of ArcA- and TorR-like OmpR family response regulators; ...
 3-108 7.97e-18

phosphoacceptor receiver (REC) domain of ArcA- and TorR-like OmpR family response regulators; This subfamily includes Escherichia coli TorR and ArcA, both OmpR family response regulators that mediate adaptation to changes in various respiratory growth conditions. The TorS-TorR two-component system (TCS) is responsible for the tight regulation of the torCAD operon, which encodes the trimethylamine N-oxide (TMAO) reductase respiratory system in response to anaerobic conditions and the presence of TMAO. The ArcA-ArcB TCS is involved in cell growth during anaerobiosis. ArcA is a global regulator that controls more than 30 operons involved in redox regulation (the Arc modulon). OmpR family DNA-binding response regulators are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381134 [Multi-domain]  Cd Length: 113  Bit Score: 76.27  E-value: 7.97e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100   3 PAILVVDDDVAVCELLQDVLSEHVFTVLTCHTGQDAVNRVQQDPgIALVLLDMMLPDINGLQVLLQLQKqRPSLPVVMLT 82
Cdd:cd17619    1 PHILIVEDEPVTRATLKSYFEQEGYDVSEAGDGEEMRQILARQD-IDLVLLDINLPGKDGLSLTRELRE-QSEVGIILVT 78

                         90       100
                 ....*....|....*....|....*.
gi 505383100  83 GLGSESDVVVGLEMGADDYIGKPFNP 108
Cdd:cd17619   79 GRDDEVDRIVGLEIGADDYVTKPFNP 104
REC_OmpR_PrrA-like cd17627
phosphoacceptor receiver (REC) domain of PrrA-like OmpR family response regulators; The ...
 5-106 2.46e-17

phosphoacceptor receiver (REC) domain of PrrA-like OmpR family response regulators; The Mycobacterium tuberculosis PrrA is part of the PrrA/PrrB two-component system (TCS) that has been implicated in early intracellular multiplication and is essential for viability. Also included in this subfamily is Mycobacterium tuberculosis MprA, part of the MprAB TCS that regulates EspR, a key regulator of the ESX-1 secretion system, and is required for establishment and maintenance of persistent infection in a tissue- and stage-specific fashion. PrrA and MprA belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381142 [Multi-domain]  Cd Length: 116  Bit Score: 75.11  E-value: 2.46e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100   5 ILVVDDDVAVCELLQDVLSEHVFTVLTCHTGQDAVNRVQQDPGIALVLlDMMLPDINGLQVLLQLQKQRPSLPVVMLTGL 84
Cdd:cd17627    1 ILVVDDDRAVRESLRRSLRFEGYEVETAVDGAEALRVISGNRPDAVVL-DVMMPRLDGLEVCRRLRAAGNDLPILVLTAR 79

                         90       100
                 ....*....|....*....|..
gi 505383100  85 GSESDVVVGLEMGADDYIGKPF 106
Cdd:cd17627   80 DSVSDRVAGLDAGADDYLVKPF 101
PRK10336 PRK10336
two-component system response regulator QseB;
5-230 1.03e-16

two-component system response regulator QseB;


Pssm-ID: 182387 [Multi-domain]  Cd Length: 219  Bit Score: 76.09  E-value: 1.03e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100   5 ILVVDDDVAVCELLQDVLSEHVFTVLTCHTGQDAVNRVQQDPGIAlVLLDMMLPDINGLQVLLQLQKQRPSLPVVMLTGL 84
Cdd:PRK10336   3 ILLIEDDMLIGDGIKTGLSKMGFSVDWFTQGRQGKEALYSAPYDA-VILDLTLPGMDGRDILREWREKGQREPVLILTAR 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100  85 GSESDVVVGLEMGADDYIGKPFNPRVVVARVKAVLRRT-GALDAEPAAPRVegitfngwTLDTTRCeLSDPQRNTVPLTQ 163
Cdd:PRK10336  82 DALAERVEGLRLGADDYLCKPFALIEVAARLEALMRRTnGQASNELRHGNV--------MLDPGKR-IATLAGEPLTLKP 152

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 505383100 164 GEYGLLLALTQNARRVLSREQLLELTHSESAEVFDRTIDVLIMRLRRKIEVNphqplLIKTIRGLGY 230
Cdd:PRK10336 153 KEFALLELLMRNAGRVLPRKLIEEKLYTWDEEVTSNAVEVHVHHLRRKLGSD-----FIRTVHGIGY 214
REC_hyHK_CKI1_RcsC-like cd17546
phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinases/response regulators ...
 5-108 1.19e-16

phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinases/response regulators similar to Arabidopsis thaliana CKI1 and Escherichia coli RcsC; This family is composed of hybrid sensor histidine kinases/response regulators that are sensor histidine kinases (HKs) fused with a REC domain, similar to the sensor histidine kinase CKI1 from Arabidopsis thaliana, which is involved in multi-step phosphorelay (MSP) signaling that mediates responses to a variety of important stimuli in plants. MSP involves a signal being transferred from HKs via histidine phosphotransfer proteins (AHP1-AHP5) to nuclear response regulators. The CKI1 REC domain specifically interacts with the downstream signaling protein AHP2, AHP3 and AHP5. The plant MSP system has evolved from the prokaryotic two-component system (TCS), which allows organisms to sense and respond to changes in environmental conditions. This family also includes bacterial hybrid sensor HKs such as Escherichia coli RcsC, which is a component of the Rcs signalling pathway that controls a variety of physiological functions like capsule synthesis, cell division, and motility. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381099 [Multi-domain]  Cd Length: 113  Bit Score: 73.27  E-value: 1.19e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100   5 ILVVDDDVAVCELLQDVLSEHVFTVLTCHTGQDAVNRVQQDPgIALVLLDMMLPDINGLQVLLQ---LQKQRPSLPVVML 81
Cdd:cd17546    1 VLVVDDNPVNRKVLKKLLEKLGYEVDVAENGQEALELLKEEP-FDLVLMDLQMPVMDGLEATRRireLEGGGRRTPIIAL 79

                         90       100
                 ....*....|....*....|....*..
gi 505383100  82 TGLGSESDVVVGLEMGADDYIGKPFNP 108
Cdd:cd17546   80 TANALEEDREKCLEAGMDDYLSKPVKL 106
YesN COG4753
Two-component response regulator, YesN/AraC family, consists of REC and AraC-type DNA-binding ...
 5-105 1.55e-16

Two-component response regulator, YesN/AraC family, consists of REC and AraC-type DNA-binding domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443786 [Multi-domain]  Cd Length: 103  Bit Score: 72.50  E-value: 1.55e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100   5 ILVVDDDVAVCELLQDVLSEH--VFTVLTCHTGQDAVNRVQQDPgIALVLLDMMLPDINGLQVLLQLQKQRPSLPVVMLT 82
Cdd:COG4753    2 VLIVDDEPLIREGLKRILEWEagFEVVGEAENGEEALELLEEHK-PDLVITDINMPGMDGLELLEAIRELDPDTKIIILS 80

                         90       100
                 ....*....|....*....|...
gi 505383100  83 GLGSESDVVVGLEMGADDYIGKP 105
Cdd:COG4753   81 GYSDFEYAQEAIKLGADDYLLKP 103
REC_OmpR_PmrA-like cd17624
phosphoacceptor receiver (REC) domain of PmrA-like OmpR family response regulators; This ...
 5-106 2.34e-16

phosphoacceptor receiver (REC) domain of PmrA-like OmpR family response regulators; This subfamily contains various OmpR family response regulators including PmrA, BasR, QseB, tctD, and RssB, which are components of two-component regulatory systems (TCSs). The PmrA/PmrB TCS controls transcription of genes that are involved in lipopolysaccharide modification in the outer membrane of bacteria, increasing bacterial resistance to host-derived antimicrobial peptides. The BasS/BasR TCS functions as an iron- and zinc-sensing transcription regulator. The QseB/QseC TCS activates the flagella regulon by activating transcription of FlhDC. The RssA/RssB TCS regulates swarming behavior in Serratia marcescens. OmpR family DNA-binding response regulators contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381139 [Multi-domain]  Cd Length: 115  Bit Score: 72.52  E-value: 2.34e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100   5 ILVVDDDVAVCELLQDVLSEHVFTVLTCHTGQDAVNRVQQDPgIALVLLDMMLPDINGLQVLLQLQKQRPSLPVVMLTGL 84
Cdd:cd17624    1 ILLVEDDALLGDGLKTGLRKAGYAVDWVRTGAEAEAALASGP-YDLVILDLGLPDGDGLDLLRRWRRQGQSLPVLILTAR 79

                         90       100
                 ....*....|....*....|..
gi 505383100  85 GSESDVVVGLEMGADDYIGKPF 106
Cdd:cd17624   80 DGVDDRVAGLDAGADDYLVKPF 101
REC_CheY cd17542
phosphoacceptor receiver (REC) domain of chemotaxis protein CheY; The chemotaxis response ...
 3-108 3.98e-16

phosphoacceptor receiver (REC) domain of chemotaxis protein CheY; The chemotaxis response regulator CheY contains a stand-alone REC domain. Chemotaxis is a behavior known for motile bacteria that directs their movement in response to chemical gradients. CheY is involved in transmitting sensory signals from chemoreceptors to the flagellar motors. Phosphorylated CheY interacts with the flagella switch components FliM and FliY, which causes counterclockwise rotation of the flagella, resulting in smooth swimming. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381097 [Multi-domain]  Cd Length: 117  Bit Score: 71.93  E-value: 3.98e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100   3 PAILVVDDDVAVCELLQDVLSEHVFTVL-TCHTGQDAVNRVQQ-DPGiaLVLLDMMLPDINGLQVLLQLQKQRPSLPVVM 80
Cdd:cd17542    1 KKVLIVDDAAFMRMMLKDILTKAGYEVVgEAANGEEAVEKYKElKPD--LVTMDITMPEMDGIEALKEIKKIDPNAKVIM 78

                         90       100
                 ....*....|....*....|....*...
gi 505383100  81 LTGLGSESDVVVGLEMGADDYIGKPFNP 108
Cdd:cd17542   79 CSAMGQEEMVKEAIKAGAKDFIVKPFQP 106
REC_PA4781-like cd19920
phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase PA4781 and similar ...
 5-106 5.01e-16

phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase PA4781 and similar domains; Pseudomonas aeruginosa cyclic di-GMP phosphodiesterase PA4781 contains an N-terminal REC domain and a C-terminal catalytic HD-GYP domain, characteristics of RpfG family response regulators. PA4781 is involved in cyclic di-3',5'-GMP (c-di-GMP) hydrolysis/degradation in a two-step reaction via the linear intermediate pGpG to produce GMP. Its unphosphorylated REC domain prevents accessibility of c-di-GMP to the active site. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381147 [Multi-domain]  Cd Length: 103  Bit Score: 71.39  E-value: 5.01e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100   5 ILVVDDDVAVCELLQDVLSEHVFTVLTCHTGQDAVNRVQQDPgIALVLLDMMLPDINGLQVLLQLQKQrPS---LPVVML 81
Cdd:cd19920    1 ILIVDDVPDNLRLLSELLRAAGYRVLVATDGQQALQRAQAEP-PDLILLDVMMPGMDGFEVCRRLKAD-PAtrhIPVIFL 78

                         90       100
                 ....*....|....*....|....*
gi 505383100  82 TGLGSESDVVVGLEMGADDYIGKPF 106
Cdd:cd19920   79 TALTDTEDKVKGFELGAVDYITKPF 103
pleD PRK09581
response regulator PleD; Reviewed
 1-107 6.96e-16

response regulator PleD; Reviewed


Pssm-ID: 236577 [Multi-domain]  Cd Length: 457  Bit Score: 76.09  E-value: 6.96e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100   1 MKPAILVVDDDVAVCELLQDVLSEHVFTVLTCHTGQDAVNRVQQDPgIALVLLDMMLPDINGLQVLLQLQKQrPS---LP 77
Cdd:PRK09581   1 MTARILVVDDIPANVKLLEAKLLAEYYTVLTASSGAEAIAICEREQ-PDIILLDVMMPGMDGFEVCRRLKSD-PAtthIP 78

                         90       100       110
                 ....*....|....*....|....*....|
gi 505383100  78 VVMLTGLGSESDVVVGLEMGADDYIGKPFN 107
Cdd:PRK09581  79 VVMVTALDDPEDRVRGLEAGADDFLTKPIN 108
REC_OmpR_RegX3-like cd17621
phosphoacceptor receiver (REC) domain of RegX3-like OmpR family response regulators; RegX3 is ...
 5-105 2.19e-15

phosphoacceptor receiver (REC) domain of RegX3-like OmpR family response regulators; RegX3 is a member of the SenX3-RegX3 two-component system that is involved in phosphate-sensing signal transduction. Phosphorylated RegX3 functions as a transcriptional activator of phoA. It induces transcription in phosphate limiting environment and also controls expression of several critical metabolic enzymes in aerobic condition. RegX3 belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381136 [Multi-domain]  Cd Length: 99  Bit Score: 69.53  E-value: 2.19e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100   5 ILVVDDDVAVCELLQDVLSEHVFTVLTCHTGQDAVNRVQQDpGIALVLLDMMLPDINGLQVLLQLQKqRPSLPVVMLTGL 84
Cdd:cd17621    1 VLVVEDEESFSDPLAYLLRKEGFEVTVATDGPAALAEFDRA-GADIVLLDLMLPGLSGTEVCRQLRA-RSNVPVIMVTAK 78

                         90       100
                 ....*....|....*....|.
gi 505383100  85 GSESDVVVGLEMGADDYIGKP 105
Cdd:cd17621   79 DSEIDKVVGLELGADDYVTKP 99
CadC1 COG3710
DNA-binding winged helix-turn-helix (wHTH) domain [Transcription];
137-237 2.26e-15

DNA-binding winged helix-turn-helix (wHTH) domain [Transcription];


Pssm-ID: 442924 [Multi-domain]  Cd Length: 106  Bit Score: 69.55  E-value: 2.26e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100 137 ITFNGWTLDTTRCELSDPQRnTVPLTQGEYGLLLALTQNARRVLSREQLLELTHsESAEVFDRTIDVLIMRLRRKIEVNP 216
Cdd:COG3710    3 YRFGDFRLDPARRELLRDGE-PVRLSPRAFDLLLLLLEHPGRVVSRDELLAAVW-PGRVVSDNSLTQAISRLRKALGDDG 80

                         90       100
                 ....*....|....*....|.
gi 505383100 217 HQPLLIKTIRGLGYVFATDVS 237
Cdd:COG3710   81 LEPRLIRTVPRRGYRLVAPVE 101
PRK10529 PRK10529
DNA-binding transcriptional activator KdpE; Provisional
 5-232 2.89e-15

DNA-binding transcriptional activator KdpE; Provisional


Pssm-ID: 182522 [Multi-domain]  Cd Length: 225  Bit Score: 72.14  E-value: 2.89e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100   5 ILVVDDDVAVCELLQDVLSEHVFTVLTCHTGQ----DAVNRvQQDpgiaLVLLDMMLPDINGLQVLLQLQKQRpSLPVVM 80
Cdd:PRK10529   4 VLIVEDEQAIRRFLRTALEGDGMRVFEAETLQrgllEAATR-KPD----LIILDLGLPDGDGIEFIRDLRQWS-AIPVIV 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100  81 LTGLGSESDVVVGLEMGADDYIGKPFNPRVVVARVKAVLRR-TGALDAEPAaprvegITFNGWTLDTTRCELSDPQRNtV 159
Cdd:PRK10529  78 LSARSEESDKIAALDAGADDYLSKPFGIGELQARLRVALRRhSATPAPDPL------VKFSDVTVDLAARVIHRGEEE-V 150

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 505383100 160 PLTQGEYGLLLALTQNARRVLSREQLLELTHSESAEVFDRTIDVLIMRLRRKIEVNPHQPLLIKTIRGLGYVF 232
Cdd:PRK10529 151 HLTPIEFRLLAVLLNNAGKVLTQRQLLNQVWGPNAVEHSHYLRIYMGHLRQKLEQDPARPRHFITETGIGYRF 223
REC_NtrC1-like cd17572
phosphoacceptor receiver (REC) domain of nitrogen regulatory protein C 1 (NtrC1) from Aquifex ...
 5-107 8.90e-15

phosphoacceptor receiver (REC) domain of nitrogen regulatory protein C 1 (NtrC1) from Aquifex aeolicus and similar NtrC family response regulators; NtrC family proteins are transcriptional regulators that have REC, AAA+ ATPase/sigma-54 interaction, and DNA-binding output domains. This subfamily of NtrC proteins include Aquifex aeolicus NtrC1 and Vibrio quorum-sensing signal integrator LuxO. The N-terminal REC domain of NtrC proteins regulate the activity of the protein and its phosphorylation controls the AAA+ domain oligomerization, while the central AAA+ domain participates in nucleotide binding, hydrolysis, oligomerization, and sigma54 interaction. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381114 [Multi-domain]  Cd Length: 121  Bit Score: 68.38  E-value: 8.90e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100   5 ILVVDDDVAVCELLQDVLSEHVFTVLTCHTGQDAVNRVQQDPgIALVLLDMMLPDINGLQVLLQLQKQRPSLPVVMLTGL 84
Cdd:cd17572    1 VLLVEDSPSLAALYQEYLSDEGYKVTHVETGKEALAFLSDQP-PDVVLLDLKLPDMSGMEILKWIQERSLPTSVIVITAH 79

                         90       100
                 ....*....|....*....|...
gi 505383100  85 GSESDVVVGLEMGADDYIGKPFN 107
Cdd:cd17572   80 GSVDIAVEAMRLGAYDFLEKPFD 102
REC_RegA-like cd17563
phosphoacceptor receiver (REC) domain of photosynthetic apparatus regulatory protein RegA; ...
 3-107 1.01e-14

phosphoacceptor receiver (REC) domain of photosynthetic apparatus regulatory protein RegA; Rhodobacter sphaeroides RegA, also called response regulator PrrA, is the DNA binding regulatory protein of a redox-responsive two-component regulatory system RegB/RegA that is involved in transactivating anaerobic expression of the photosynthetic apparatus. It contains a REC domain and a DNA-binding helix-turn-helix output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381111 [Multi-domain]  Cd Length: 112  Bit Score: 67.85  E-value: 1.01e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100   3 PAILVVDDDVAVCELLQDVLSEHVFTVLTCHTGQDAVNRVQQDPgIALVLLDMMLPDINGLQVLLQLQKQRPSLPVVMLT 82
Cdd:cd17563    1 KSLLLVDDDEVFAERLARALERRGFEVETAHSVEEALALAREEK-PDYAVLDLRLGGDSGLDLIPPLRALQPDARIVVLT 79

                         90       100
                 ....*....|....*....|....*
gi 505383100  83 GLGSESDVVVGLEMGADDYIGKPFN 107
Cdd:cd17563   80 GYASIATAVEAIKLGADDYLAKPAD 104
REC_OmpR_EcPhoP-like cd19934
phosphoacceptor receiver (REC) domain of EcPhoP-like OmpR family response regulators; ...
 5-122 1.76e-14

phosphoacceptor receiver (REC) domain of EcPhoP-like OmpR family response regulators; Escherichia coli PhoP (EcPhoP) is part of the PhoQ/PhoP two-component system (TCS) that regulates virulence genes and plays an essential role in the response of the bacteria to the environment of their mammalian hosts, sensing several stimuli such as extracellular magnesium limitation, low pH, the presence of cationic antimicrobial peptides, and osmotic upshift. This subfamily also includes Brucella suis FeuP, part of the FeuPQ TCS that is involved in the regulation of iron uptake, and Microchaete diplosiphon RcaC, which is required for chromatic adaptation. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381161 [Multi-domain]  Cd Length: 117  Bit Score: 67.69  E-value: 1.76e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100   5 ILVVDDDVAVCELLQDVLSEHVFTVLTCHTGQDAVNRVQQDPgIALVLLDMMLPDINGLQVLLQLQKQRPSLPVVMLTGL 84
Cdd:cd19934    1 LLLVEDDALLAAQLKEQLSDAGYVVDVAEDGEEALFQGEEEP-YDLVVLDLGLPGMDGLSVLRRWRSEGRATPVLILTAR 79

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 505383100  85 GSESDVVVGLEMGADDYIGKPFNPRVVVARVKAVLRRT 122
Cdd:cd19934   80 DSWQDKVEGLDAGADDYLTKPFHIEELLARLRALIRRA 117
PRK10643 PRK10643
two-component system response regulator PmrA;
1-230 2.46e-14

two-component system response regulator PmrA;


Pssm-ID: 182612 [Multi-domain]  Cd Length: 222  Bit Score: 69.68  E-value: 2.46e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100   1 MKpaILVVDDDVAVCELLQDVLSEHVFTVLTCHTGQDAvNRVQQDPGIALVLLDMMLPDINGLQVLLQLQKQRPSLPVVM 80
Cdd:PRK10643   1 MK--ILIVEDDTLLLQGLILALQTEGYACDCASTAREA-EALLESGHYSLVVLDLGLPDEDGLHLLRRWRQKKYTLPVLI 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100  81 LTGLGSESDVVVGLEMGADDYIGKPFNPRVVVARVKAVLRR-TGALDAEpaaprvegITFNGWTLDTTRCELSdPQRNTV 159
Cdd:PRK10643  78 LTARDTLEDRVAGLDVGADDYLVKPFALEELHARIRALIRRhQGQGENE--------LQVGNLTLNLGRQQVW-LDGQEL 148

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 505383100 160 PLTQGEYGLLLALTQNARRVLSREQLLELTHSESAEVFDRTIDVLIMRLRRKIEVNPhqpllIKTIRGLGY 230
Cdd:PRK10643 149 ILTPKEFALLSRLMLKAGSPVHREILYQDIYNWDDEPSSNTLEVHIHNLRDKVGKDR-----IRTVRGFGY 214
REC_OmpR_KdpE-like cd17620
phosphoacceptor receiver (REC) domain of KdpE-like OmpR family response regulators; KdpE is a ...
 5-105 9.41e-14

phosphoacceptor receiver (REC) domain of KdpE-like OmpR family response regulators; KdpE is a component of the KdpD/KdpE two-component system (TCS) and is activated when histidine kinase KdpD senses a drop in external K+ concentration or upshift in ionic osmolarity, resulting in the expression of a heterooligomeric transporter KdpFABC. In addition, the KdpD/KdpE TCS is also an adaptive regulator involved in the virulence and intracellular survival of pathogenic bacteria. KdpE is a member of the OmpR family of DNA-binding response regulators that contain REC and winged helix-turn-helix (wHTH) DNA-binding output effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381135 [Multi-domain]  Cd Length: 99  Bit Score: 64.88  E-value: 9.41e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100   5 ILVVDDDVAVCELLQDVLSEHVFTVLTCHTGQDAVNRVQQDPGiALVLLDMMLPDINGLQVLLQLQKQRpSLPVVMLTGL 84
Cdd:cd17620    1 ILVIEDEPQIRRFLRTALEAHGYRVFEAETGQEGLLEAATRKP-DLIILDLGLPDMDGLEVIRRLREWS-AVPVIVLSAR 78

                         90       100
                 ....*....|....*....|.
gi 505383100  85 GSESDVVVGLEMGADDYIGKP 105
Cdd:cd17620   79 DEESDKIAALDAGADDYLTKP 99
REC_DctD-like cd17549
phosphoacceptor receiver (REC) domain of C4-dicarboxylic acid transport protein D (DctD) and ...
 5-108 9.98e-14

phosphoacceptor receiver (REC) domain of C4-dicarboxylic acid transport protein D (DctD) and similar proteins; C4-dicarboxylic acid transport protein D (DctD) is part of the two-component regulatory system DctB/DctD, which regulates C4-dicarboxylate transport via regulation of expression of the dctPQM operon and dctA. It is an activator of sigma(54)-RNA polymerase holoenzyme that uses the energy released from ATP hydrolysis to stimulate the isomerization of a closed promoter complex to an open complex capable of initiating transcription. DctD is a member of the NtrC family, characterized by a domain architecture containing an N-terminal REC domain, followed by a central sigma-54 interaction/ATPase domain, and a C-terminal DNA binding domain. The ability of the central domain to hydrolyze ATP and thus to interact effectively with a complex of RNA polymerase, sigma54, and promoter, is controlled by the phosphorylation status of the REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381101 [Multi-domain]  Cd Length: 130  Bit Score: 65.97  E-value: 9.98e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100   5 ILVVDDDVAVCELLQDVLSEHVFTVLTCHTGQDAVNRVQQD-PGIalVLLDMMLPDINGLQVLLQLQKQRPSLPVVMLTG 83
Cdd:cd17549    1 VLLVDDDADVREALQQTLELAGFRVRAFADAEEALAALSPDfPGV--VISDIRMPGMDGLELLAQIRELDPDLPVILITG 78

                         90       100
                 ....*....|....*....|....*...
gi 505383100  84 LGsesDV---VVGLEMGADDYIGKPFNP 108
Cdd:cd17549   79 HG---DVpmaVEAMRAGAYDFLEKPFDP 103
REC_OmpR_VirG cd17594
phosphoacceptor receiver (REC) domain of VirG-like OmpR family response regulators; VirG is ...
 5-106 1.20e-13

phosphoacceptor receiver (REC) domain of VirG-like OmpR family response regulators; VirG is part of the VirA/VirG two-component system that regulates the expression of virulence (vir) genes. The histidine kinase VirA senses a phenolic wound response signal, undergoes autophosphorylation, and phosphorelays to the VirG response regulator, which induces transcription of the vir regulon. VirG belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381125 [Multi-domain]  Cd Length: 113  Bit Score: 65.16  E-value: 1.20e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100   5 ILVVDDDVAVCELLQDVLSEHVFTVLTCHTGQDAVNRVQQDPgIALVLLDMMLPDINGLQVLLQLQKqRPSLPVVMLTG- 83
Cdd:cd17594    2 VLVVDDDAAMRHLLILYLRERGFDVTAAADGAEEARLMLHRR-VDLVLLDLRLGQESGLDLLRTIRA-RSDVPIIIISGd 79

                         90       100
                 ....*....|....*....|...
gi 505383100  84 LGSESDVVVGLEMGADDYIGKPF 106
Cdd:cd17594   80 RRDEIDRVVGLELGADDYLAKPF 102
PRK10365 PRK10365
sigma-54-dependent response regulator transcription factor ZraR;
5-131 3.98e-13

sigma-54-dependent response regulator transcription factor ZraR;


Pssm-ID: 182412 [Multi-domain]  Cd Length: 441  Bit Score: 68.13  E-value: 3.98e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100   5 ILVVDDDVAVCELLQDVLSEHVFTVLTCHTGQDAVNRVQQDPgIALVLLDMMLPDINGLQVLLQLQKQRPSLPVVMLTGL 84
Cdd:PRK10365   8 ILVVDDDISHCTILQALLRGWGYNVALANSGRQALEQVREQV-FDLVLCDVRMAEMDGIATLKEIKALNPAIPVLIMTAY 86

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 505383100  85 GSESDVVVGLEMGADDYIGKPFNPRVVVARVKAVLRRTGALDAEPAA 131
Cdd:PRK10365  87 SSVETAVEALKTGALDYLIKPLDFDNLQATLEKALAHTHSIDAETPA 133
REC_RssB-like cd17555
phosphoacceptor receiver (REC) domain of Pseudomonas aeruginosa RssB and similar domains; ...
 3-105 3.99e-13

phosphoacceptor receiver (REC) domain of Pseudomonas aeruginosa RssB and similar domains; Pseudomonas aeruginosa RssB is an orphan atypical response regulator containing a REC domain and a PP2C-type protein phosphatase output domain. Its function is still unknown. Escherichia RssB, which is not included in this subfamily, is a ClpX adaptor protein which alters ClpX specificity by mediating a specific interaction between ClpX and the substrates such as RpoS, an RNA polymerase sigma factor. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381107 [Multi-domain]  Cd Length: 116  Bit Score: 63.76  E-value: 3.99e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100   3 PAILVVDDDVAVCELLQDVLSEHVFTVLTCHTGQDAVNRVQQDPgIALVLLDMMLPDINGLQVLLQLQKQRPSLPVVMLT 82
Cdd:cd17555    1 ATILVIDDDEVVRESIAAYLEDSGFQVLQAADGRQGLELFRSEQ-PDLVLCDLRMPEMDGLEVLKQITKESPDTPVIVVS 79

                         90       100
                 ....*....|....*....|...
gi 505383100  83 GLGSESDVVVGLEMGADDYIGKP 105
Cdd:cd17555   80 GAGVMSDAVEALRLGAWDYLTKP 102
REC_OmpR_CtrA cd17616
phosphoacceptor receiver (REC) domain of CtrA-like OmpR family response regulators; CtrA is ...
 5-107 9.60e-13

phosphoacceptor receiver (REC) domain of CtrA-like OmpR family response regulators; CtrA is part of the CckA-ChpT-CtrA phosphorelay that is conserved in alphaproteobacteria and is important in orchestrating the cell cycle, polar development, and flagellar biogenesis. CtrA is the master regulator of flagella synthesis genes and also regulates genes involved in the cell cycle, exopolysaccharide synthesis, and cyclic-di-GMP signaling. CtrA is active as a transcription factor when phosphorylated. It is a member of the OmpR family of DNA-binding response regulators, characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381132 [Multi-domain]  Cd Length: 114  Bit Score: 62.81  E-value: 9.60e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100   5 ILVVDDDVAVCELLQDVLSEHVFTVLTCHTGQDAVnRVQQDPGIALVLLDMMLPDINGLQVLLQLQKQRPSLPVVMLTGL 84
Cdd:cd17616    1 VLLIEDDSATAQSIELMLKSEGFNVYTTDLGEEGL-DLGKLYDYDIILLDLNLPDMSGYEVLRTLRLAKVKTPILILSGL 79

                         90       100
                 ....*....|....*....|...
gi 505383100  85 GSESDVVVGLEMGADDYIGKPFN 107
Cdd:cd17616   80 ADIEDKVKGLGFGADDYMTKPFH 102
REC_2_GGDEF cd17544
second phosphoacceptor receiver (REC) domain of uncharacterized GGDEF domain proteins; This ...
 5-108 5.42e-12

second phosphoacceptor receiver (REC) domain of uncharacterized GGDEF domain proteins; This family is composed of uncharacterized PleD-like response regulators that contain two N-terminal REC domains and a C-terminal diguanylate cyclase output domain with the characteristic GGDEF motif at the active site. Unlike PleD which contains a REC-like adaptor domain, the second REC domain of these uncharacterized GGDEF domain proteins, described in this model, contains characteristic metal-binding and active site residues. PleD response regulators are global regulators of cell metabolism in some important human pathogens. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381098 [Multi-domain]  Cd Length: 122  Bit Score: 61.00  E-value: 5.42e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100   5 ILVVDDDVAVCELLQDVLSEHVFTVLTCHTGQDAVNRVQQDPGIALVLLDMMLPDINGLQVLLQLQKQRPS--LPVVMLT 82
Cdd:cd17544    3 VLVVDDSATSRNHLRALLRRHNFQVLEAANGQEALEVLEQHPDIKLVITDYNMPEMDGFELVREIRKKYSRdqLAIIGIS 82

                         90       100
                 ....*....|....*....|....*.
gi 505383100  83 GLGSESDVVVGLEMGADDYIGKPFNP 108
Cdd:cd17544   83 ASGDNALSARFIKAGANDFLTKPFLP 108
REC_OmpR_ChvI-like cd19936
phosphoacceptor receiver (REC) domain of ChvI-like OmpR family response regulators; ...
 5-105 5.75e-12

phosphoacceptor receiver (REC) domain of ChvI-like OmpR family response regulators; Sinorhizobium meliloti ChvI is part of the ExoS/ChvI two-component regulatory system (TCS) that is required for nitrogen-fixing symbiosis and exopolysaccharide synthesis. ExoS/ChvI also play important roles in regulating biofilm formation, motility, nutrient utilization, and the viability of free-living bacteria. ChvI belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381163 [Multi-domain]  Cd Length: 99  Bit Score: 60.15  E-value: 5.75e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100   5 ILVVDDDVAVCELLQDVLSEHVFTVLTCHTGQDAVNRVQQDPgIALVLLDMMLPDINGLQVLLQLQKqRPSLPVVMLTGL 84
Cdd:cd19936    1 IALVDDDRNILTSVSMALEAEGFSVETYTDGASALDGLNARP-PDLAILDIKMPRMDGMELLQRLRQ-KSTLPVIFLTSK 78

                         90       100
                 ....*....|....*....|.
gi 505383100  85 GSESDVVVGLEMGADDYIGKP 105
Cdd:cd19936   79 DDEIDEVFGLRMGADDYITKP 99
FixJ COG4566
DNA-binding response regulator, FixJ family, consists of REC and HTH domains [Signal ...
 5-108 9.49e-12

DNA-binding response regulator, FixJ family, consists of REC and HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443623 [Multi-domain]  Cd Length: 196  Bit Score: 62.04  E-value: 9.49e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100   5 ILVVDDDVAVCELLQDVLSEHVFTVLTCHTGQDAVNRVQQDpGIALVLLDMMLPDINGLQVLLQLQKQRPSLPVVMLTGL 84
Cdd:COG4566    2 VYIVDDDEAVRDSLAFLLESAGLRVETFASAEAFLAALDPD-RPGCLLLDVRMPGMSGLELQEELAARGSPLPVIFLTGH 80

                         90       100
                 ....*....|....*....|....
gi 505383100  85 GSESDVVVGLEMGADDYIGKPFNP 108
Cdd:COG4566   81 GDVPMAVRAMKAGAVDFLEKPFDD 104
REC_TrrA-like cd17554
phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator TrrA and ...
 5-107 1.01e-11

phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator TrrA and similar domains; Thermotoga maritima contains a two-component signal transduction system (TCS) composed of the ThkA sensory histidine kinase (HK) and its cognate response regulator (RR) TrrA; the specific function of the system is unknown. TCSs couple environmental stimuli to adaptive responses. TrrA is a stand-alone RR containing only a REC domain with no output/effector domain. The REC domain itself functions as an effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381106 [Multi-domain]  Cd Length: 113  Bit Score: 59.93  E-value: 1.01e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100   5 ILVVDDDVAVCELLQDVLSEHVFTVLTCHTGQDAVNRVQQDPgIALVLLDMMLPDINGLQVLLQLQKQRPSLPVVMLTGL 84
Cdd:cd17554    3 ILVVDDEENIRELYKEELEDEGYEVVTAGNGEEALEKLESED-PDLVILDIKMPGMDGLETLRKIREKKPDLPVIICTAY 81

                         90       100
                 ....*....|....*....|....
gi 505383100  85 -GSESDVVVgleMGADDYIGKPFN 107
Cdd:cd17554   82 sEYKSDFSS---WAADAYVVKSSD 102
REC_hyHK cd17598
phosphoacceptor receiver (REC) domain of uncharacterized hybrid sensor histidine kinase ...
 5-107 1.12e-11

phosphoacceptor receiver (REC) domain of uncharacterized hybrid sensor histidine kinase/response regulators; Typically, two-component regulatory systems (TCSs) consist of a sensor (histidine kinase) that responds to specific input(s) by modifying the output of a cognate response regulator (RR). TCSs allow organisms to sense and respond to changes in environmental conditions. Hybrid sensor histidine kinase/response regulators contain all the elements of a classical TCS in a single polypeptide chain. RRs share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381128 [Multi-domain]  Cd Length: 118  Bit Score: 60.03  E-value: 1.12e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100   5 ILVVDDDVAVCELLQDVLSEHVFTVLTCHTGQDAVNRVQQD-PgiALVLLDMMLPDINGLQVLLQLQKqRPSL---PVVM 80
Cdd:cd17598    1 ILIVEDSPTQAEQLKHILEEQGYKVQVARNGREALAMLAEHrP--TLVISDIVMPEMDGYELCRKIKS-DPDLkdiPVIL 77

                         90       100
                 ....*....|....*....|....*..
gi 505383100  81 LTGLGSESDVVVGLEMGADDYIGKPFN 107
Cdd:cd17598   78 LTTLSDPRDVIRGLECGADNFITKPYD 104
REC_2_DhkD-like cd17580
second phosphoacceptor receiver (REC) domain of Dictyostelium discoideum hybrid signal ...
 5-108 1.48e-11

second phosphoacceptor receiver (REC) domain of Dictyostelium discoideum hybrid signal transduction histidine kinase D and similar domains; Dictyostelium discoideum hybrid signal transduction histidine kinase D (DhkD) is a large protein that contains two histidine kinase (HK) and two REC domains on the intracellular side of a single pass transmembrane domain, and extracellular PAS and PAC domains that likely are involved in ligand binding. This model represents the second REC domain and similar domains. DhkD activates the cAMP phosphodiesterase RegA to ensure proper prestalk and prespore patterning, tip formation, and the vertical elongation of the mound into a finger, in Dictyostelium discoideum. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381118 [Multi-domain]  Cd Length: 112  Bit Score: 59.39  E-value: 1.48e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100   5 ILVVDDDVAVCELLQDVLSEHVFTVLTCHTGQDAVNRVQQDPgIALVLLDMMLPDINGLQVLLQLQKQRP--SLPVVMLT 82
Cdd:cd17580    1 ILVVDDNEDAAEMLALLLELEGAEVTTAHSGEEALEAAQRFR-PDVILSDIGMPGMDGYELARRLRELPWlaNTPAIALT 79

                         90       100
                 ....*....|....*....|....*.
gi 505383100  83 GLGSESDVVVGLEMGADDYIGKPFNP 108
Cdd:cd17580   80 GYGQPEDRERALEAGFDAHLVKPVDP 105
PRK11361 PRK11361
acetoacetate metabolism transcriptional regulator AtoC;
1-107 1.91e-11

acetoacetate metabolism transcriptional regulator AtoC;


Pssm-ID: 183099 [Multi-domain]  Cd Length: 457  Bit Score: 62.94  E-value: 1.91e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100   1 MKPA--ILVVDDDVAVCELLQDVLSEHVFTVLTCHTGQDAVNRVQQDPgIALVLLDMMLPDINGLQVLLQLQKQRPSLPV 78
Cdd:PRK11361   1 MTAInrILIVDDEDNVRRMLSTAFALQGFETHCANNGRTALHLFADIH-PDVVLMDIRMPEMDGIKALKEMRSHETRTPV 79

                         90       100
                 ....*....|....*....|....*....
gi 505383100  79 VMLTGLGSESDVVVGLEMGADDYIGKPFN 107
Cdd:PRK11361  80 ILMTAYAEVETAVEALRCGAFDYVIKPFD 108
spore_0_A TIGR02875
sporulation transcription factor Spo0A; Spo0A, the stage 0 sporulation protein A, is a ...
 2-107 2.65e-11

sporulation transcription factor Spo0A; Spo0A, the stage 0 sporulation protein A, is a transcription factor critical for the initiation of sporulation. It contains a response regulator receiver domain (pfam00072). In Bacillus subtilis, it works together with response regulator Spo0F and the phosphotransferase Spo0B, both of which are missing from at least some sporulating species and thus not part of the endospore forming bacteria minimal gene set. Spo0A, however, is universal among endospore-forming species. [Cellular processes, Sporulation and germination]


Pssm-ID: 131922 [Multi-domain]  Cd Length: 262  Bit Score: 61.73  E-value: 2.65e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100    2 KPAILVVDDDVAVCELLQDVLS--EHVFTVLTCHTGQDAVNRVQ-QDPGIalVLLDMMLPDINGL----QVLLQLQKQRP 74
Cdd:TIGR02875   2 KIRIVIADDNKEFCNLLKEYLAaqPDMEVVGVAHNGVDALELIKeQQPDV--VVLDIIMPHLDGIgvleKLNEIELSARP 79

                          90       100       110
                  ....*....|....*....|....*....|...
gi 505383100   75 SlpVVMLTGLGSESDVVVGLEMGADDYIGKPFN 107
Cdd:TIGR02875  80 R--VIMLSAFGQEKITQRAVALGADYYVLKPFD 110
REC_RR468-like cd17552
phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator RR468 and ...
 5-108 9.84e-11

phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator RR468 and similar domains; Thermotoga maritima RR468 (encoded by gene TM0468) is the cognate response regulator (RR) of the class I histidine kinase HK853 (product of gene TM0853). HK853/RR468 comprise a two-component system (TCS) that couples environmental stimuli to adaptive responses. This subfamily also includes Fremyella diplosiphon complementary adaptation response regulator homolog RcaF, a small RR that is involved in four-step phosphorelays of the complementary chromatic adaptation (CCA) system that occurs in many cyanobacteria. Both RR468 and RcaF are stand-alone RRs containing only a REC domain with no output/effector domain. The REC domain itself functions as an effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381104 [Multi-domain]  Cd Length: 121  Bit Score: 57.56  E-value: 9.84e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100   5 ILVVDDDVAVCELLQDVLsEHV--FTVLTCHTGQDAVNRVQQDPGIAlVLLDMMLPDINGLQVLLQLQKqRP---SLPVV 79
Cdd:cd17552    4 ILVIDDEEDIREVVQACL-EKLagWEVLTASSGQEGLEKAATEQPDA-ILLDVMMPDMDGLATLKKLQA-NPetqSIPVI 80

                         90       100
                 ....*....|....*....|....*....
gi 505383100  80 MLTGLGSESDVVVGLEMGADDYIGKPFNP 108
Cdd:cd17552   81 LLTAKAQPSDRQRFASLGVAGVIAKPFDP 109
REC_Spo0A cd17561
phosphoacceptor receiver (REC) domain of Spo0A; Spo0A is a response regulator of the ...
 5-106 3.80e-10

phosphoacceptor receiver (REC) domain of Spo0A; Spo0A is a response regulator of the phosphorelay system in the early stage of spore formation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress and may act in the with sigma factor spo0H to control the expression of some genes that are critical to the sporulation process. Spo0A contains a regulatory N-terminal REC domain and a C-terminal DNA-binding transcription activation domain as its effector/output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381109 [Multi-domain]  Cd Length: 108  Bit Score: 55.69  E-value: 3.80e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100   5 ILVVDDDVAVCELLQDVLSEHV-FTVL-TCHTGQDAVNRV-QQDPGIalVLLDMMLPDINGL----QVLLQLQKQRPSlp 77
Cdd:cd17561    4 VLIADDNREFVQLLEEYLNSQPdMEVVgVAHNGQEALELIeEKEPDV--LLLDIIMPHLDGIgvleKLRRMRLEKRPK-- 79

                         90       100
                 ....*....|....*....|....*....
gi 505383100  78 VVMLTGLGSESDVVVGLEMGADDYIGKPF 106
Cdd:cd17561   80 IIMLTAFGQEDITQRAVELGASYYILKPF 108
REC_Ycf29 cd19927
phosphoacceptor receiver (REC) domain of probable transcriptional regulator Ycf29; Ycf29 is a ...
 5-105 4.07e-10

phosphoacceptor receiver (REC) domain of probable transcriptional regulator Ycf29; Ycf29 is a probable response regulator of a two-component system (TCS), typically consisting a sensor and a response regulator, that functions in adaptation to changing environments. Processes regulated by TCSs in bacteria include sporulation, pathogenicity, virulence, chemotaxis, and membrane transport. Ycf29 contains an N-terminal REC domain and a LuxR-type helix-turn-helix DNA-binding output domain. REC domains function as phosphorylation-mediated switches within RRs, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381154 [Multi-domain]  Cd Length: 102  Bit Score: 55.46  E-value: 4.07e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100   5 ILVVDDDVAVCELLQDVLSEHVFTVLTCHTGQDAVNRVQQDPgIALVLLDMMLPDING--LQVLLQLQKQRPSLPVVMLT 82
Cdd:cd19927    1 ILLVDDDPGIRLAVKDYLEDQGFTVIAASNGLEALDLLNQYI-PDLIISDIIMPGVDGysLLGKLRKNADFDTIPVIFLT 79

                         90       100
                 ....*....|....*....|...
gi 505383100  83 GLGSESDVVVGLEMGADDYIGKP 105
Cdd:cd19927   80 AKGMTSDRIKGYNAGCDGYLSKP 102
REC_RpfG-like cd17551
phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase response regulator ...
 5-108 4.10e-10

phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase response regulator RpfG and similar proteins; Cyclic di-GMP phosphodiesterase response regulator RpfG, together with sensory/regulatory protein RpfC, constitute a two-component system implicated in sensing and responding to the diffusible signal factor (DSF) that is essential for cell-cell signaling. RpfC is a hybrid sensor/histidine kinase that phosphorylates and activates RpfG, which degrades cyclic di-GMP to GMP, leading to the activation of Clp, a global transcriptional regulator that regulates a large set of genes in the DSF pathway. RpfG contains a CheY-like receiver domain attached to a histidine-aspartic acid-glycine-tyrosine-proline (HD-GYP) cyclic di-GMP phosphodiesterase domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381103 [Multi-domain]  Cd Length: 118  Bit Score: 55.91  E-value: 4.10e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100   5 ILVVDDDVAVCELLQDVLSEHVFTVLTCHT-GQDAVNRVQQDPgIALVLLDMMLPDINGLQVLLQLQKQRPS--LPVVML 81
Cdd:cd17551    3 ILIVDDNPTNLLLLEALLRSAGYLEVVSFTdPREALAWCRENP-PDLILLDYMMPGMDGLEFIRRLRALPGLedVPIVMI 81

                         90       100
                 ....*....|....*....|....*..
gi 505383100  82 TGLGSESDVVVGLEMGADDYIGKPFNP 108
Cdd:cd17551   82 TADTDREVRLRALEAGATDFLTKPFDP 108
REC_typeB_ARR-like cd17584
phosphoacceptor receiver (REC) domain of type B Arabidopsis response regulators (ARRs) and ...
 5-108 4.39e-10

phosphoacceptor receiver (REC) domain of type B Arabidopsis response regulators (ARRs) and similar domains; Type-B ARRs (Arabidopsis response regulators) are a class of MYB-type transcription factors that act as major players in the transcriptional activation of cytokinin-responsive genes. They directly regulate the expression of type-A ARR genes and other downstream target genes. Cytokinin is a plant hormone implicated in many growth and development processes including shoot organogenesis, leaf senescence, sink/source relationships, vascular development, lateral bud release, and photomorphogenic development. Cytokinin signaling involves a phosphorelay cascade by histidine kinase receptors (AHKs), histidine phosphotransfer proteins (AHPs) and downstream ARRs. ARRs are divided into two groups, type-A and -B, according to their sequence and domain structure. Type-B ARRs contain a receiver (REC) domain and a large C-terminal extension that has characteristics of an effector or output domain, with a Myb-like DNA binding domain referred to as the GARP domain. The GARP domain is a motif specific to plant transcription factors. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381121 [Multi-domain]  Cd Length: 115  Bit Score: 55.71  E-value: 4.39e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100   5 ILVVDDDVAVCELLQDVLSEHVFTVLTCHTGQDAVNRVQQDPG-IALVLLDMMLPDINGLQVLLQLQKQrPSLPVVMLTG 83
Cdd:cd17584    1 VLVVDDDPTCLAILKRMLLRCGYQVTTCTDAEEALSMLRENKDeFDLVITDVHMPDMDGFEFLELIRLE-MDLPVIMMSA 79

                         90       100
                 ....*....|....*....|....*
gi 505383100  84 LGSESDVVVGLEMGADDYIGKPFNP 108
Cdd:cd17584   80 DGSTSTVMKGLAHGACDYLLKPVSI 104
REC_NarL-like cd17535
phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family ...
 5-108 5.23e-10

phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family response regulators; The NarL family is one of the more abundant families of DNA-binding response regulators (RRs). Members of the NarL family contain a REC domain and a helix-turn-helix (HTH) DNA-binding output domain, with a majority of members containing a LuxR-type HTH domain. They function as transcriptional regulators. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381090 [Multi-domain]  Cd Length: 117  Bit Score: 55.60  E-value: 5.23e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100   5 ILVVDDDVAVCELLQDVLS-EHVFTVL-TCHTGQDAVNRVQQDPgIALVLLDMMLPDINGLQVLLQLQKQRPSLPVVMLT 82
Cdd:cd17535    1 VLIVDDHPLVREGLRRLLEsEPDIEVVgEAADGEEALALLRELR-PDVVLMDLSMPGMDGIEALRRLRRRYPDLKVIVLT 79

                         90       100
                 ....*....|....*....|....*.
gi 505383100  83 GLGSESDVVVGLEMGADDYIGKPFNP 108
Cdd:cd17535   80 AHDDPEYVLRALKAGAAGYLLKDSSP 105
AmiR COG3707
Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding ...
 1-108 1.08e-09

Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding antiterminator (ANTAR) domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 442921 [Multi-domain]  Cd Length: 194  Bit Score: 56.12  E-value: 1.08e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100   1 MKPA-ILVVDDDVAVCELLQDVLSEHVFTVLT-CHTGQDAVNRVQQ-DPGiaLVLLDMMLPDINGLQVLLQLQKQRPsLP 77
Cdd:COG3707    1 MRGLrVLVVDDEPLRRADLREGLREAGYEVVAeAADGEDAVELVRElKPD--LVIVDIDMPDRDGLEAARQISEERP-AP 77

                         90       100       110
                 ....*....|....*....|....*....|.
gi 505383100  78 VVMLTGLGSESDVVVGLEMGADDYIGKPFNP 108
Cdd:COG3707   78 VILLTAYSDPELIERALEAGVSAYLVKPLDP 108
REC_HP-RR-like cd17573
phosphoacceptor receiver (REC) domain of orphan response regulator HP-RR and similar proteins; ...
 5-107 1.12e-09

phosphoacceptor receiver (REC) domain of orphan response regulator HP-RR and similar proteins; Helicobacter pylori response regulator hp1043 (HP-RR) is an orphan response regulator which is phosphorylation-independent and is essential for growth. HP-RR functions as a cell growth-associated regulator in the absence of post-translational modification. Members of this subfamily contain REC and DNA-binding output domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381115 [Multi-domain]  Cd Length: 110  Bit Score: 54.36  E-value: 1.12e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100   5 ILVVDDDVAVCELLQDVLSEHVFTVLTCHTGQDA---VNRVQQDpgiaLVLLDMMLPDINGLQVLLQLQKQRPSLPVVML 81
Cdd:cd17573    1 ILLIEDDSTLGKEISKGLNEKGYQADVAESLKDGeyyIDIRNYD----LVLVSDKLPDGNGLSIVSRIKEKHPSIVVIVL 76

                         90       100
                 ....*....|....*....|....*.
gi 505383100  82 TGLGSESDVVVGLEMGADDYIGKPFN 107
Cdd:cd17573   77 SDNPKTEQEIEAFKEGADDYIAKPFD 102
REC smart00448
cheY-homologous receiver domain; CheY regulates the clockwise rotation of E. coli flagellar ...
 5-58 1.38e-09

cheY-homologous receiver domain; CheY regulates the clockwise rotation of E. coli flagellar motors. This domain contains a phosphoacceptor site that is phosphorylated by histidine kinase homologues.


Pssm-ID: 214668 [Multi-domain]  Cd Length: 55  Bit Score: 52.57  E-value: 1.38e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 505383100     5 ILVVDDDVAVCELLQDVLSEHVFTVLTCHTGQDAVNRVQQDPgIALVLLDMMLP 58
Cdd:smart00448   3 ILVVDDDPLLRELLKALLEKEGYEVDEATDGEEALELLKEEK-PDLILLDIMMP 55
Spo0A COG5801
Stage 0 sporulation initiation regulator Spo0A (response regulator, REC-HTH domains) [Cell ...
 5-107 1.70e-09

Stage 0 sporulation initiation regulator Spo0A (response regulator, REC-HTH domains) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444503 [Multi-domain]  Cd Length: 264  Bit Score: 56.35  E-value: 1.70e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100   5 ILVVDDDVAVCELLQDVLSEHV-FTVL-TCHTGQDAVNRVQ-QDPGIalVLLDMMLPDINGL----QVLLQLQKQRPSlp 77
Cdd:COG5801    7 VLIADDNREFCELLEEYLSSQPdMEVVgVAYNGLEALELIEeKKPDV--VILDIIMPHLDGLgvleKLREMNLEKRPK-- 82

                         90       100       110
                 ....*....|....*....|....*....|
gi 505383100  78 VVMLTGLGSESDVVVGLEMGADDYIGKPFN 107
Cdd:COG5801   83 VIMLTAFGQEDITQRAVELGADYYILKPFD 112
REC_PilR cd19926
phosphoacceptor receiver (REC) domain of type 4 fimbriae expression regulatory protein PilR ...
 5-105 1.83e-09

phosphoacceptor receiver (REC) domain of type 4 fimbriae expression regulatory protein PilR and similar proteins; Pseudomonas aeruginosa PilR is the response regulator of the PilS/PilR two-component regulatory system (PilSR TCS) that acts in conjunction with sigma-54 to regulate the expression of type 4 pilus (T4P) major subunit PilA. In addition, the PilSR TCS regulates flagellum-dependent swimming motility and pilus-dependent twitching motility. PilR contains an N-terminal REC domain, a central sigma-54 interaction domain, and a C-terminal Fis-type helix-turn-helix DNA-binding domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381153 [Multi-domain]  Cd Length: 100  Bit Score: 53.70  E-value: 1.83e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100   5 ILVVDDDVAVCELLQDVLSEHVFTVLTCHTGQDAVNRVQQDPgIALVLLDMMLPDINGLQVLLQLQKQRPSLPVVMLTGL 84
Cdd:cd19926    1 VLVVDDEPDIRELLEITLGRMGLDVRSARNVKEARELLASEP-YDLCLTDMRLPDGSGLELVQHIQQRLPQTPVAVITAY 79

                         90       100
                 ....*....|....*....|.
gi 505383100  85 GSESDVVVGLEMGADDYIGKP 105
Cdd:cd19926   80 GSLDTAIEALKAGAFDFLTKP 100
PRK15115 PRK15115
response regulator GlrR; Provisional
 2-105 2.23e-09

response regulator GlrR; Provisional


Pssm-ID: 185070 [Multi-domain]  Cd Length: 444  Bit Score: 56.77  E-value: 2.23e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100   2 KPA-ILVVDDDVAVCELLQDVLSEHVFTVLTCHTGQDAVNRVQQDPgIALVLLDMMLPDINGLQVLLQLQKQRPSLPVVM 80
Cdd:PRK15115   4 KPAhLLLVDDDPGLLKLLGMRLTSEGYSVVTAESGQEALRVLNREK-VDLVISDLRMDEMDGMQLFAEIQKVQPGMPVII 82

                         90       100
                 ....*....|....*....|....*
gi 505383100  81 LTGLGSESDVVVGLEMGADDYIGKP 105
Cdd:PRK15115  83 LTAHGSIPDAVAATQQGVFSFLTKP 107
REC_OmpR_NsrR-like cd18159
phosphoacceptor receiver (REC) domain of Streptococcus agalactiae NsrR-like OmpR family ...
 5-106 3.05e-09

phosphoacceptor receiver (REC) domain of Streptococcus agalactiae NsrR-like OmpR family response regulators; Streptococcus agalactiae NsrR is a lantibiotic resistance-associated response regulator and is part of the nisin resistance operon. It is a member of the NsrRK two-component system (TCS) that is involved in the regulation of lantibiotic resistance genes such as a membrane-associated lipoprotein of LanI, and the nsr gene cluster which encodes for the resistance protein NSR and the ABC transporter NsrFP, both conferring resistance against nisin. This subfamily also includes Staphylococcus epidermidis GraR, part of the GraR/GraS TCS involved in resistance against cationic antimicrobial peptides, and Bacillus subtilis BceR, part of the BceS/BceR TCS involved in the regulation of bacitracin resistance. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381143 [Multi-domain]  Cd Length: 113  Bit Score: 53.05  E-value: 3.05e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100   5 ILVVDDDVAVCELLQDVLSEHVFTVltcHTGQDAVN------RVQQDpgiaLVLLDMMLPDINGLQVLLQLQKQRPsLPV 78
Cdd:cd18159    1 ILIVEDDETIASLLKKHLEKWGYEV---VLIEDFEDvleeflQFKPD----LVLLDINLPYFDGFYWCREIRQISN-VPI 72

                         90       100
                 ....*....|....*....|....*...
gi 505383100  79 VMLTGLGSESDVVVGLEMGADDYIGKPF 106
Cdd:cd18159   73 IFISSRDDNMDQVMAINMGGDDYITKPF 100
REC_Rcp-like cd17557
phosphoacceptor receiver (REC) domain of cyanobacterial phytochrome response regulator Rcp and ...
 5-108 1.08e-08

phosphoacceptor receiver (REC) domain of cyanobacterial phytochrome response regulator Rcp and similar domains; This family is composed of response regulators (RRs) that are members of phytochrome-associated, light-sensing two-component signal transduction pathways such as Synechocystis sp. Rcp1, Tolypothrix sp. RcpA, and Agrobacterium tumefaciens bacteriophytochrome response regulator AtBRR. They are stand-alone RRs containing only a REC domain with no output/effector domain. The REC domain itself functions as an effector domain. Also included in this family us Methanosaeta harundinacea methanogenesis regulatory protein FilR2, also a stand-alone RR. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381108 [Multi-domain]  Cd Length: 129  Bit Score: 52.03  E-value: 1.08e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100   5 ILVVDDDVAVCELLQDVLSEH--VFTVLTCHTGQDAVN------RVQQDPGIALVLLDMMLPDINGlqvllqlqkqR--- 73
Cdd:cd17557    2 ILLVEDNPGDAELIQEAFKEAgvPNELHVVRDGEEALDflrgegEYADAPRPDLILLDLNMPRMDG----------Fevl 71

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 505383100  74 ------PSL---PVVMLTGLGSESDVVVGLEMGADDYIGKPFNP 108
Cdd:cd17557   72 reikadPDLrriPVVVLTTSDAEEDIERAYELGANSYIVKPVDF 115
REC_FixJ cd17537
phosphoacceptor receiver (REC) domain of FixJ family response regulators; FixJ family response ...
 5-107 1.40e-08

phosphoacceptor receiver (REC) domain of FixJ family response regulators; FixJ family response regulators contain an N-terminal receiver domain (REC) and a C-terminal LuxR family helix-turn-helix (HTH) DNA-binding output domain. The Sinorhizobium meliloti two-component system FixL/FixJ regulates nitrogen fixation in response to oxygen during symbiosis. Under microaerobic conditions, the kinase FixL phosphorylates the response regulator FixJ resulting in the regulation of nitrogen fixation genes such as nifA and fixK. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381092 [Multi-domain]  Cd Length: 116  Bit Score: 51.44  E-value: 1.40e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100   5 ILVVDDDVAVCELLQDVLSEHVFTVLTCHTGQDAVNRVQQD-PGIalVLLDMMLPDINGLQVLLQLQKQRPSLPVVMLTG 83
Cdd:cd17537    3 VYVVDDDEAVRDSLAFLLRSVGLAVKTFTSASAFLAAAPPDqPGC--LVLDVRMPGMSGLELQDELLARGSNIPIIFITG 80

                         90       100
                 ....*....|....*....|....
gi 505383100  84 LGSESDVVVGLEMGADDYIGKPFN 107
Cdd:cd17537   81 HGDVPMAVEAMKAGAVDFLEKPFR 104
LytT COG3279
DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction ...
 5-108 2.49e-08

DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction mechanisms];


Pssm-ID: 442510 [Multi-domain]  Cd Length: 235  Bit Score: 52.90  E-value: 2.49e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100   5 ILVVDDDVAVCELLQDVLSEHVFT--VLTCHTGQDAVNRVQQDPgIALVLLDMMLPDINGLQVLLQLQKQRPSLPVVMLT 82
Cdd:COG3279    4 ILIVDDEPLARERLERLLEKYPDLevVGEASNGEEALELLEEHK-PDLVFLDIQMPGLDGFELARQLRELDPPPPIIFTT 82

                         90       100
                 ....*....|....*....|....*.
gi 505383100  83 glGSESDVVVGLEMGADDYIGKPFNP 108
Cdd:COG3279   83 --AYDEYALEAFEVNAVDYLLKPIDE 106
REC_hyHK_blue-like cd18161
phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinase/response regulators ...
 5-106 2.80e-08

phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinase/response regulators similar to Pseudomonas savastanoi blue-light-activated histidine kinase; Typically, two-component regulatory systems (TCSs) consist of a sensor (histidine kinase) that responds to specific input(s) by modifying the output of a cognate response regulator (RR). TCSs allow organisms to sense and respond to changes in environmental conditions. Hybrid sensor histidine kinase (HK)/response regulators contain all the elements of a classical TCS in a single polypeptide chain. Pseudomonas savastanoi blue-light-activated histidine kinase is a photosensitive HK and RR that is involved in increased bacterial virulence upon exposure to light. RRs share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381145 [Multi-domain]  Cd Length: 102  Bit Score: 50.42  E-value: 2.80e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100   5 ILVVDDDVAVCELLQDVLSEHVFTVLTCHTGQDAVNRVQQDPGIALVLLDMMLPD-INGLQVLLQLQKQRPSLPVVMLTG 83
Cdd:cd18161    1 VLVVEDDPDVRRLTAEVLEDLGYTVLEAASGDEALDLLESGPDIDLLVTDVIMPGgMNGSQLAEEARRRRPDLKVLLTSG 80

                         90       100
                 ....*....|....*....|...
gi 505383100  84 LGSESDVVVGLEMGAdDYIGKPF 106
Cdd:cd18161   81 YAENAIEGGDLAPGV-DVLSKPF 102
REC_CheB-like cd17541
phosphoacceptor receiver (REC) domain of chemotaxis response regulator protein-glutamate ...
 5-108 4.13e-08

phosphoacceptor receiver (REC) domain of chemotaxis response regulator protein-glutamate methylesterase CheB and similar chemotaxis proteins; Methylesterase CheB is a chemotaxis response regulator with an N-terminal REC domain and a C-terminal methylesterase domain. Chemotaxis is a behavior known in motile bacteria that directs their movement in response to chemical gradients. CheB is a phosphorylation-activated response regulator involved in the reversible modification of bacterial chemotaxis receptors. It catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR. The CheB REC domain packs against the active site of the C-terminal domain and inhibits methylesterase activity by directly restricting access to the active site. Also included in this family is chemotaxis response regulator CheY, which contains a stand-alone REC domain, and an uncharacterized subfamily composed of proteins containing an N-terminal REC domain and a C-terminal CheY-P phosphatase (CheC) domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381096 [Multi-domain]  Cd Length: 125  Bit Score: 50.47  E-value: 4.13e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100   5 ILVVDDDVAVCELLQDVLSEH----VftVLTCHTGQDAVNRVQQ---DpgiaLVLLDMMLPDINGLQVLLQLQKQRPsLP 77
Cdd:cd17541    3 VLIVDDSAVMRKLLSRILESDpdieV--VGTARDGEEALEKIKElkpD----VITLDIEMPVMDGLEALRRIMAERP-TP 75

                         90       100       110
                 ....*....|....*....|....*....|...
gi 505383100  78 VVMLTGLGSE-SDVVV-GLEMGADDYIGKPFNP 108
Cdd:cd17541   76 VVMVSSLTEEgAEITLeALELGAVDFIAKPSGG 108
REC_NtrC cd19919
phosphoacceptor receiver (REC) domain of DNA-binding transcriptional regulator NtrC; ...
 5-106 4.22e-08

phosphoacceptor receiver (REC) domain of DNA-binding transcriptional regulator NtrC; DNA-binding transcriptional regulator NtrC is also called nitrogen regulation protein NR(I) or nitrogen regulator I (NRI). It contains an N-terminal receiver (REC) domain, followed by a sigma-54 interaction domain, and a C-terminal helix-turn-helix DNA-binding domain. It is part of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. DNA-binding response regulator NtrC is phosphorylated by NtrB; phosphorylation of the N-terminal REC domain activates the central sigma-54 interaction domain and leads to the transcriptional activation from promoters that require sigma(54)-containing RNA polymerase. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381146 [Multi-domain]  Cd Length: 116  Bit Score: 50.35  E-value: 4.22e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100   5 ILVVDDDVAVCELLQDVLSEHVFTVLTCHTGQDAVNRVQQDPGiALVLLDMMLPDINGLQVLLQLQKQRPSLPVVMLTGL 84
Cdd:cd19919    3 VWIVDDDSSIRWVLERALAGAGLTVTSFENAQEALAALASSQP-DVLISDIRMPGMDGLALLAQIKQRHPDLPVIIMTAH 81

                         90       100
                 ....*....|....*....|..
gi 505383100  85 GSESDVVVGLEMGADDYIGKPF 106
Cdd:cd19919   82 SDLDSAVSAYQGGAFEYLPKPF 103
REC_RcNtrC-like cd19928
phosphoacceptor receiver (REC) domain of Rhodobacter capsulatus nitrogen regulatory protein C ...
 5-105 4.55e-08

phosphoacceptor receiver (REC) domain of Rhodobacter capsulatus nitrogen regulatory protein C (NtrC) and similar NtrC family response regulators; NtrC family proteins are transcriptional regulators that have REC, AAA+ ATPase/sigma-54 interaction, and DNA-binding output domains. This subfamily of NtrC proteins include NtrC, also called nitrogen regulator I (NRI), from Rhodobacter capsulatus, Azospirillum brasilense, and Azorhizobium caulinodans. NtrC is part of the NtrB/NtrC two-component system that controls the expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. The N-terminal REC domain of NtrC proteins regulate the activity of the protein and its phosphorylation controls the AAA+ domain oligomerization, while the central AAA+ domain participates in nucleotide binding, hydrolysis, oligomerization, and sigma54 interaction. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381155 [Multi-domain]  Cd Length: 100  Bit Score: 49.81  E-value: 4.55e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100   5 ILVVDDDVAVCELLQDVLSEHVFTVLTCHTGQDAVNRVQQDPGiALVLLDMMLPDINGLQVLLQLQKQRPSLPVVMLTGL 84
Cdd:cd19928    1 ILVADDDRAIRTVLTQALGRAGYEVRTTGNAATLWRWVEEGEG-DLVITDVVMPDENGLDLIPRIKKARPDLPIIVMSAQ 79

                         90       100
                 ....*....|....*....|.
gi 505383100  85 GSESDVVVGLEMGADDYIGKP 105
Cdd:cd19928   80 NTLMTAVKAAERGAFEYLPKP 100
REC_HupR cd17596
phosphoacceptor receiver (REC) domain of hydrogen uptake protein regulator (HupR); Members of ...
 3-108 5.32e-08

phosphoacceptor receiver (REC) domain of hydrogen uptake protein regulator (HupR); Members of this subfamily are response regulator components of two-component systems that regulates hydrogenase activity, including HupR and HoxA. HupR is part of the HupT/HupR system that controls the synthesis of the membrane-bound [NiFe]hydrogenase, HupSL, of the photosynthetic bacterium Rhodobacter capsulatus. It belongs to the nitrogen regulatory protein C (NtrC) family of response regulators, which activate transcription by RNA polymerase (RNAP) in response to a change in the environment. HupR is an unusual member of this family as it activates transcription when unphosphorylated, and transcription is inhibited by phosphorylation. Proteins in this subfamily contain an N-terminal REC domain, a central sigma-54 interaction domain that lacks ATPase activity, and a C-terminal DNA-binding domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381127 [Multi-domain]  Cd Length: 133  Bit Score: 50.44  E-value: 5.32e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100   3 PAILVVDDDVAVCELLQDVLSEHvFTVLTCHTGQDAVnRVQQDPGIALVLLDMMLPDINGLQVLLQLQKQRPSLPVVMLT 82
Cdd:cd17596    1 PTILVVDDEVRSLEALRRTLEED-FDVLTAASAEEAL-AILEEEWVQVILCDQRMPGTTGVEFLKEVRERWPEVVRIIIS 78

                         90       100
                 ....*....|....*....|....*..
gi 505383100  83 GLGSESDVVVGL-EMGADDYIGKPFNP 108
Cdd:cd17596   79 GYTDSEDIIAGInEAGIYQYLTKPWHP 105
REC_HupR-like cd17569
phosphoacceptor receiver (REC) domain of hydrogen uptake protein regulator (HupR) and similar ...
 3-62 5.92e-08

phosphoacceptor receiver (REC) domain of hydrogen uptake protein regulator (HupR) and similar domains; This family is composed of mostly uncharacterized response regulators with similarity to the REC domains of response regulator components of two-component systems that regulates hydrogenase activity, including HupR and HoxA. HupR is part of the HupT/HupR system that controls the synthesis of the membrane-bound [NiFe]hydrogenase, HupSL, of the photosynthetic bacterium Rhodobacter capsulatus. It contains an N-terminal REC domain, a central sigma-54 interaction domain that lacks ATPase activity, and a C-terminal DNA-binding domain. Members of this family contain a REC domain and various output domains including the cyclase homology domain (CHD) and the c-di-GMP phosphodiesterase domains, HD-GYP and EAL. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381113 [Multi-domain]  Cd Length: 118  Bit Score: 49.71  E-value: 5.92e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100   3 PAILVVDDDVAVCELLQDVLSEHVFTVLTCHTGQDAVNRVQQDPgIALVLLDMMLPDING 62
Cdd:cd17569    1 PTILLVDDEPNILKALKRLLRREGYEVLTATSGEEALEILKQEP-VDVVISDQRMPGMDG 59
REC_citrate_TCS cd19925
phosphoacceptor receiver (REC) domain of citrate family two-component system response ...
 4-106 2.27e-07

phosphoacceptor receiver (REC) domain of citrate family two-component system response regulators; This family includes Lactobacillus paracasei MaeR, Escherichia coli DcuR and DpiA, Klebsiella pneumoniae CitB, as well as Bacillus DctR, MalR, and CitT. These are all response regulators of two-component systems (TCSs) from the citrate family, and are involved in the transcriptional regulation of genes associated with L-malate catabolism (MaeRK), citrate-specific fermentation (DpiAB, CitAB), plasmid inheritance (DpiAB), anaerobic fumarate respiratory system (DcuRS), and malate transport/utilization (MalKR). REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381152 [Multi-domain]  Cd Length: 118  Bit Score: 48.01  E-value: 2.27e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100   4 AILVVDDDVAVCELLQDVLSEH-VFTVL-TCHTGQDAVNRVQqDPGIALVLLDMMLPDINGLQVLLQLQKQRPSLPVVML 81
Cdd:cd19925    2 NVLIVEDDPMVAEIHRAYVEQVpGFTVIgTAGTGEEALKLLK-ERQPDLILLDIYLPDGNGLDLLRELRAAGHDVDVIVV 80

                         90       100
                 ....*....|....*....|....*.
gi 505383100  82 TGlGSESDVV-VGLEMGADDYIGKPF 106
Cdd:cd19925   81 TA-ANDVETVrEALRLGVVDYLIKPF 105
REC_Spo0F-like cd17553
phosphoacceptor receiver (REC) domain of Spo0F and similar domains; Spo0F, a stand-alone ...
 5-107 2.78e-07

phosphoacceptor receiver (REC) domain of Spo0F and similar domains; Spo0F, a stand-alone response regulator containing only a REC domain with no output/effector domain, controls sporulation in Bacillus subtilis through the exchange of a phosphoryl group. Bacillus subtilis forms spores when conditions for growth become unfavorable. The initiation of sporulation is controlled by a phosphorelay (an expanded version of the two-component system) that consists of four main components: a histidine kinase (KinA), a secondary messenger (Spo0F), a phosphotransferase (Spo0B), and a transcription factor (Spo0A). REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381105 [Multi-domain]  Cd Length: 117  Bit Score: 47.93  E-value: 2.78e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100   5 ILVVDDDVAVCELLQDVLSEHVFTVLTCHTGQDAVNRVQQDPGiALVLLDMMLPDINGLQVLLQLQKQRPSLPVVMLTGL 84
Cdd:cd17553    3 ILIVDDQYGIRILLNEVFNKEGYQTFQAANGLQALDIVTKERP-DLVLLDMKIPGMDGIEILKRMKVIDENIRVIIMTAY 81

                         90       100
                 ....*....|....*....|...
gi 505383100  85 GSESDVVVGLEMGADDYIGKPFN 107
Cdd:cd17553   82 GELDMIQESKELGALTHFAKPFD 104
REC_CheY_CheY3 cd19923
phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY3 and similar CheY ...
 1-108 2.78e-07

phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY3 and similar CheY family proteins; CheY family chemotaxis response regulators (RRs) comprise about 17% of bacterial RRs and almost half of all RRs in archaea. This subfamily contains Vibrio cholerae CheY3, Escherichia coli CheY, and similar CheY family RRs. CheY proteins control bacterial motility and participate in signaling phosphorelays and in protein-protein interactions. CheY RRs contain only the REC domain with no output/effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381150 [Multi-domain]  Cd Length: 119  Bit Score: 48.10  E-value: 2.78e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100   1 MKpaILVVDDDVAVCELLQDVLSEHVFT-VLTCHTGQDAVNRVQQdPGIALVLLDMMLPDINGLQVLLQ--LQKQRPSLP 77
Cdd:cd19923    1 MK--VLVVDDFSTMRRIIKNLLKELGFNnVEEAEDGVDALEKLKA-GGFDFVITDWNMPNMDGLELLKTirADGALSHLP 77

                         90       100       110
                 ....*....|....*....|....*....|.
gi 505383100  78 VVMLTGLGSESDVVVGLEMGADDYIGKPFNP 108
Cdd:cd19923   78 VLMVTAEAKKENVIAAAQAGVNNYIVKPFTA 108
REC_DivK-like cd17548
phosphoacceptor receiver (REC) domain of DivK and similar proteins; Caulobacter crescentus ...
 5-107 2.95e-07

phosphoacceptor receiver (REC) domain of DivK and similar proteins; Caulobacter crescentus DivK is an essential response regulator that is involved in the complex phosphorelay pathways controlling both cell division and motility. It localizes cell cycle regulators to specific poles of the cell during division. DivK contains a stand-alone REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381100 [Multi-domain]  Cd Length: 115  Bit Score: 47.92  E-value: 2.95e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100   5 ILVVDDDVAVCELLQDVLSEHVFTVLTCHTGQDAVNRVQQDPgIALVLLDMMLPDINGLQVLLQLQKQrPSL---PVVML 81
Cdd:cd17548    2 ILIVEDNPLNMKLARDLLESAGYEVLEAADGEEALEIARKEK-PDLILMDIQLPGMDGLEATRLLKED-PATrdiPVIAL 79

                         90       100
                 ....*....|....*....|....*.
gi 505383100  82 TGLGSESDVVVGLEMGADDYIGKPFN 107
Cdd:cd17548   80 TAYAMKGDREKILEAGCDGYISKPID 105
REC_CheV-like cd19924
phosphoacceptor receiver (REC) domain of chemotaxis protein CheV and similar proteins; This ...
 5-105 7.97e-07

phosphoacceptor receiver (REC) domain of chemotaxis protein CheV and similar proteins; This subfamily includes the REC domains of Bacillus subtilis chemotaxis protein CheV, Myxococcus xanthus gliding motility regulatory protein FrzE, and similar proteins. CheV is a hybrid protein with an N-terminal CheW-like domain and a C-terminal CheY-like REC domain. The CheV pathway is one of three systems employed by B. subtilis for sensory adaptation that contribute to chemotaxis. It is involved in the transmission of sensory signals from chemoreceptors to flagellar motors. Together with CheW, it is involved in the coupling of methyl-accepting chemoreceptors to the central two-component histidine kinase CheA. FrzE is a hybrid sensor histidine kinase/response regulator that is part of the Frz pathway that controls cell reversal frequency to support directional motility during swarming and fruiting body formation. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381151 [Multi-domain]  Cd Length: 111  Bit Score: 46.60  E-value: 7.97e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100   5 ILVVDDDVAVCELLQDVLSEHVFTVLTCHTGQDAVNRVQQDPGIALVL---LDMMLPDI-----NGLQVLLQLQKQR--P 74
Cdd:cd19924    1 ILVVDDSPTARKQLRDLLKNLGFEIAEAVDGEEALNKLENLAKEGNDLskeLDLIITDIempkmDGYELTFELRDDPrlA 80

                         90       100       110
                 ....*....|....*....|....*....|.
gi 505383100  75 SLPVVMLTGLGSESDVVVGLEMGADDYIGKP 105
Cdd:cd19924   81 NIPVILNSSLSGEFSRARGKKVGADAYLAKF 111
REC_CheY4-like cd17562
phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY4 and similar CheY ...
 4-108 9.29e-07

phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY4 and similar CheY family proteins; CheY family chemotaxis response regulators (RRs) comprise about 17% of bacterial RRs and almost half of all RRs in archaea. This subfamily contains Vibrio cholerae CheY4 and similar CheY family RRs. CheY proteins control bacterial motility and participate in signaling phosphorelays and in protein-protein interactions. CheY RRs contain only the REC domain with no output/effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381110 [Multi-domain]  Cd Length: 118  Bit Score: 46.53  E-value: 9.29e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100   4 AILVVDDDVAVCELLQDVLSEHVFTVLTCHTGQDAVNRVQQDPgIALVLLDMMLPDINGLQVLLQ--LQKQRPSLPVVML 81
Cdd:cd17562    2 KILAVDDSASIRQMVSFTLRGAGYEVVEAADGRDALSKAQSKK-FDLIITDQNMPNMDGIELIKElrKLPAYKFTPILML 80

                         90       100
                 ....*....|....*....|....*..
gi 505383100  82 TGLGSESDVVVGLEMGADDYIGKPFNP 108
Cdd:cd17562   81 TTESSDEKKQEGKAAGATGWLVKPFDP 107
PRK10610 PRK10610
chemotaxis protein CheY;
6-106 3.12e-06

chemotaxis protein CheY;


Pssm-ID: 170568 [Multi-domain]  Cd Length: 129  Bit Score: 45.35  E-value: 3.12e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100   6 LVVDDDVAVCELLQDVLSEHVF-TVLTCHTGQDAVNRVQQDpGIALVLLDMMLPDINGLQVLLQLQK--QRPSLPVVMLT 82
Cdd:PRK10610   9 LVVDDFSTMRRIVRNLLKELGFnNVEEAEDGVDALNKLQAG-GFGFVISDWNMPNMDGLELLKTIRAdgAMSALPVLMVT 87

                         90       100
                 ....*....|....*....|....
gi 505383100  83 GLGSESDVVVGLEMGADDYIGKPF 106
Cdd:PRK10610  88 AEAKKENIIAAAQAGASGYVVKPF 111
fixJ PRK09390
response regulator FixJ; Provisional
 2-106 3.39e-06

response regulator FixJ; Provisional


Pssm-ID: 181815 [Multi-domain]  Cd Length: 202  Bit Score: 46.15  E-value: 3.39e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100   2 KPAILVVDDDVAVCELLQDVLSEHVFTVLTCHTGQDAVNRVQqDPGIALVLLDMMLPDINGLQVLLQLQKQRPSLPVVML 81
Cdd:PRK09390   3 KGVVHVVDDDEAMRDSLAFLLDSAGFEVRLFESAQAFLDALP-GLRFGCVVTDVRMPGIDGIELLRRLKARGSPLPVIVM 81

                         90       100
                 ....*....|....*....|....*
gi 505383100  82 TGLGSESDVVVGLEMGADDYIGKPF 106
Cdd:PRK09390  82 TGHGDVPLAVEAMKLGAVDFIEKPF 106
PRK00742 PRK00742
chemotaxis-specific protein-glutamate methyltransferase CheB;
1-106 7.63e-06

chemotaxis-specific protein-glutamate methyltransferase CheB;


Pssm-ID: 234828 [Multi-domain]  Cd Length: 354  Bit Score: 45.91  E-value: 7.63e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100   1 MKPAILVVDDDVAVCELLQDVLSEH----VftVLTCHTGQDAVNRVQQ-DPGIalVLLDMMLPDINGLQVLLQLQKQRPs 75
Cdd:PRK00742   2 MKIRVLVVDDSAFMRRLISEILNSDpdieV--VGTAPDGLEAREKIKKlNPDV--ITLDVEMPVMDGLDALEKIMRLRP- 76

                         90       100       110
                 ....*....|....*....|....*....|....
gi 505383100  76 LPVVM---LTGLGSESdVVVGLEMGADDYIGKPF 106
Cdd:PRK00742  77 TPVVMvssLTERGAEI-TLRALELGAVDFVTKPF 109
glnG PRK10923
nitrogen regulation protein NR(I); Provisional
 1-107 8.74e-06

nitrogen regulation protein NR(I); Provisional


Pssm-ID: 182842 [Multi-domain]  Cd Length: 469  Bit Score: 46.02  E-value: 8.74e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100   1 MKPAIL-VVDDDVAVCELLQDVLSEHVFTVLTCHTGQDAVNRV-QQDPGIalVLLDMMLPDINGLQVLLQLQKQRPSLPV 78
Cdd:PRK10923   1 MQRGIVwVVDDDSSIRWVLERALAGAGLTCTTFENGNEVLEALaSKTPDV--LLSDIRMPGMDGLALLKQIKQRHPMLPV 78

                         90       100
                 ....*....|....*....|....*....
gi 505383100  79 VMLTGLGSESDVVVGLEMGADDYIGKPFN 107
Cdd:PRK10923  79 IIMTAHSDLDAAVSAYQQGAFDYLPKPFD 107
REC_CpdR_CckA-like cd18160
phosphoacceptor receiver (REC) domain of Brucella abortus CpdR and CckA, and similar domains; ...
 5-106 1.53e-05

phosphoacceptor receiver (REC) domain of Brucella abortus CpdR and CckA, and similar domains; Two-component systems (TCSs), consisting of a sensor and a response regulator, are used by bacteria to adapt to changing environments. Processes regulated by TCSs in bacteria include sporulation, pathogenicity, virulence, chemotaxis and membrane transport. Response regulators share the common phosphoacceptor REC domain and differ output domains such as DNA, RNA, ligand, and protein-binding, or enzymatic domain. CpdR is a stand-alone REC protein. CckA is a sensor histidine kinase containing N-terminal PAS domains and a C-terminal REC domain. CpdR and CckA are components of a regulatory phosphorelay system (composed of CckA, ChpT, CtrA and CpdR) that controls Brucella abortus cell growth, division, and intracellular survival inside mammalian host cells. CckA autophosphorylates in the presence of ATP and transfers a phosphoryl group to the conserved aspartic acid residue on its C-terminal REC domain, which is relayed to the ChpT phosphotransferase. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381144 [Multi-domain]  Cd Length: 103  Bit Score: 42.87  E-value: 1.53e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100   5 ILVVDDDVAVCELLQDVLSEHVFTVLTCHTGQDAVNRVQQDPGIALVLLDMMLPDINGLQVLLQLQKQRPSLPVVMLTGL 84
Cdd:cd18160    2 ILLADDEPSVRKFIVTTLKKAGYAVTEAESGAEALEKLQQGKDIDIVVTDIVMPEMDGIELAREARKIDPDVKILFISGG 81

                         90       100
                 ....*....|....*....|....*..
gi 505383100  85 GS-----ESDVVvglemGADDYIGKPF 106
Cdd:cd18160   82 AAaapelLSDAV-----GDNATLKKPF 103
CitB COG2197
DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal ...
 5-62 7.55e-05

DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 441799 [Multi-domain]  Cd Length: 131  Bit Score: 41.42  E-value: 7.55e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100   5 ILVVDDDVAVCELLQDVLSEH--VFTVLTCHTGQDAVNRVQQDPgIALVLLDMMLPDING 62
Cdd:COG2197    4 VLIVDDHPLVREGLRALLEAEpdIEVVGEAADGEEALELLEELR-PDVVLLDIRMPGMDG 62
REC_DC-like cd17534
phosphoacceptor receiver (REC) domain of modulated diguanylate cyclase and similar domains; ...
 5-62 7.65e-05

phosphoacceptor receiver (REC) domain of modulated diguanylate cyclase and similar domains; This groups includes a modulated diguanylate cyclase containing a PAS sensor domain from Desulfovibrio desulfuricans G20. Members of this group contain N-terminal REC domains and various output domains including the GGDEF, histidine kinase, and helix-turn-helix (HTH) DNA binding domains. Also included in this family is Mycobacterium tuberculosis PdtaR, a transcriptional antiterminator that contains a REC domain and an ANTAR RNA-binding output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381089 [Multi-domain]  Cd Length: 117  Bit Score: 40.85  E-value: 7.65e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100   5 ILVVDDDVAVCELLQDVLSEHVFTVL-TCHTGQDAVNRVQQDPgIALVLLDMMLP-DING 62
Cdd:cd17534    3 ILIVEDEAIIALDLKEILESLGYEVVgIADSGEEAIELAEENK-PDLILMDINLKgDMDG 61
REC_YesN-like cd17536
phosphoacceptor receiver (REC) domain of YesN and related helix-turn-helix containing response ...
 5-108 8.61e-05

phosphoacceptor receiver (REC) domain of YesN and related helix-turn-helix containing response regulators; This family is composed of uncharacterized response regulators that contain a REC domain and a AraC family helix-turn-helix (HTH) DNA-binding output domain, including Bacillus subtilis uncharacterized transcriptional regulatory protein YesN and Staphylococcus aureus uncharacterized response regulatory protein SAR0214. YesN is a member of the two-component regulatory system YesM/YesN and SAR0214 is a member of the probable two-component regulatory system SAR0215/SAR0214. Also included in this family is the AlgR-like group of LytTR/AlgR family response, which includes Pseudomonas aeruginosa positive alginate biosynthesis regulatory protein AlgR and Bacillus subtilis sensory transduction protein LytT, among others. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381091 [Multi-domain]  Cd Length: 121  Bit Score: 40.78  E-value: 8.61e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100   5 ILVVDDDVAVCELLQDVL--SEHVFT-VLTCHTGQDAVNRVQQDPgIALVLLDMMLPDINGLQVLLQLQKQRPSLPVVML 81
Cdd:cd17536    1 VLIVDDEPLIREGLKKLIdwEELGFEvVGEAENGEEALELIEEHK-PDIVITDIRMPGMDGLELIEKIRELYPDIKIIIL 79

                         90       100       110
                 ....*....|....*....|....*....|
gi 505383100  82 TGLgseSD---VVVGLEMGADDYIGKPFNP 108
Cdd:cd17536   80 SGY---DDfeyAQKAIRLGVVDYLLKPVDE 106
PRK13557 PRK13557
histidine kinase; Provisional
 5-108 1.48e-04

histidine kinase; Provisional


Pssm-ID: 237425 [Multi-domain]  Cd Length: 540  Bit Score: 42.35  E-value: 1.48e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100   5 ILVVDDDVAVCELLQDVLSEHVFTVLTCHTGQDAVNRVQQDPGIALVLLDMMLP-DINGLQVLLQLQKQRPSLPVVMLTG 83
Cdd:PRK13557 418 ILIVDDRPDVAELARMILEDFGYRTLVASNGREALEILDSHPEVDLLFTDLIMPgGMNGVMLAREARRRQPKIKVLLTTG 497

                         90       100
                 ....*....|....*....|....*
gi 505383100  84 LGSESDVVVGLEMGADDYIGKPFNP 108
Cdd:PRK13557 498 YAEASIERTDAGGSEFDILNKPYRR 522
REC_TPR cd17589
phosphoacceptor receiver (REC) domain of uncharacterized tetratricopeptide repeat (TPR) ...
 5-108 2.14e-04

phosphoacceptor receiver (REC) domain of uncharacterized tetratricopeptide repeat (TPR)-containing response regulators; Response regulators share the common phosphoacceptor REC domain and different output domains. This subfamily contains uncharacterized response regulators with TPR repeats as the effector or output domain, which might contain between 3 to 16 TPR repeats (each about 34 amino acids). TPR-containing proteins occur in all domains of life and the abundance of TPR-containing proteins in a bacterial proteome is not indicative of virulence. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays. Some members in this subfamily may contain inactive REC domains lacking canonical metal-binding and active site residues.


Pssm-ID: 381123 [Multi-domain]  Cd Length: 115  Bit Score: 39.55  E-value: 2.14e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100   5 ILVVDDDVAVCELLQDVLSEHVFT-VLTCHTGQDAVNRVQQDPgIALVLLDMMLPD-INGLQVLLQLQKQR---PSLPVV 79
Cdd:cd17589    1 FLIVDDQPTFRSMLKSMLRSLGVTrIDTASSGEEALRMCENKT-YDIVLCDYNLGKgKNGQQLLEELRHKKlisPSTVFI 79

                         90       100
                 ....*....|....*....|....*....
gi 505383100  80 MLTGLGSESDVVVGLEMGADDYIGKPFNP 108
Cdd:cd17589   80 MVTGESSRAMVLSALELEPDDYLLKPFTV 108
PRK11107 PRK11107
hybrid sensory histidine kinase BarA; Provisional
 5-62 2.71e-04

hybrid sensory histidine kinase BarA; Provisional


Pssm-ID: 236848 [Multi-domain]  Cd Length: 919  Bit Score: 41.76  E-value: 2.71e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 505383100   5 ILVVDDDVAVCELLQDVLSEHVFTVLTCHTGQDAVNRVQQDPgIALVLLDMMLPDING 62
Cdd:PRK11107 670 VMAVDDNPANLKLIGALLEEQVEHVVLCDSGHQAVEQAKQRP-FDLILMDIQMPGMDG 726
PRK10651 PRK10651
transcriptional regulator NarL; Provisional
 42-108 1.69e-03

transcriptional regulator NarL; Provisional


Pssm-ID: 182619 [Multi-domain]  Cd Length: 216  Bit Score: 38.47  E-value: 1.69e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 505383100  42 VQQDPGiaLVLLDMMLPDINGLQVLLQLQKQRPSLPVVMLTGLGSESDVVVGLEMGADDYIGKPFNP 108
Cdd:PRK10651  49 ESLDPD--LILLDLNMPGMNGLETLDKLREKSLSGRIVVFSVSNHEEDVVTALKRGADGYLLKDMEP 113
PEP_resp_reg TIGR02915
PEP-CTERM-box response regulator transcription factor; Members of this protein family share ...
 5-108 2.00e-03

PEP-CTERM-box response regulator transcription factor; Members of this protein family share full-length homology with (but do not include) the acetoacetate metabolism regulatory protein AtoC (see SP|Q06065). These proteins have a Fis family DNA binding sequence (pfam02954), a response regulator receiver domain (pfam00072), and sigma-54 interaction domain (pfam00158). [Regulatory functions, DNA interactions]


Pssm-ID: 274348 [Multi-domain]  Cd Length: 445  Bit Score: 38.96  E-value: 2.00e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100    5 ILVVDDDVAVCELLQDVLSEhvFTVLTCHTGQDAVNRV-QQDPgiALVLLDMMLPD-----INGLQVLLQLQKQRPSLPV 78
Cdd:TIGR02915   1 LLIVEDDLGLQKQLKWSFAD--YELAVAADRESAIALVrRHEP--AVVTLDLGLPPdadgaSEGLAALQQILAIAPDTKV 76

                          90       100       110
                  ....*....|....*....|....*....|
gi 505383100   79 VMLTGLGSESDVVVGLEMGADDYIGKPFNP 108
Cdd:TIGR02915  77 IVITGNDDRENAVKAIGLGAYDFYQKPIDP 106
REC_GlnL-like cd17565
phosphoacceptor receiver (REC) domain of transcriptional regulatory protein GlnL and similar ...
 5-105 3.08e-03

phosphoacceptor receiver (REC) domain of transcriptional regulatory protein GlnL and similar proteins; Bacillus subtilis GlnL is part of the GlnK-GlnL (formerly YcbA-YcbB) two-component system that positively regulates the expression of the glsA-glnT (formerly ybgJ-ybgH) operon in response to glutamine. It contains a REC domain and a DNA-binding output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381112 [Multi-domain]  Cd Length: 103  Bit Score: 36.10  E-value: 3.08e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100   5 ILVVDDDVAVCELLQDVLSEHVF-TVL-TCHTGQDAVNRVQQ-DPGIalVLLDMMLPDINGLQVLLQLQKQRPSLPVVML 81
Cdd:cd17565    1 FYIVDDDKNIIKILSDIIEDDDLgEVVgEADNGAQAYDEILFlQPDI--VLIDLLMPGMDGIQLVRKLKDTGSNGKFIMI 78

                         90       100
                 ....*....|....*....|....
gi 505383100  82 TGLGSESDVVVGLEMGADDYIGKP 105
Cdd:cd17565   79 SQVSDKEMIGKAYQAGIEFFINKP 102
REC_NarL cd19931
phosphoacceptor receiver (REC) domain of Nitrate/Nitrite response regulator L (NarL); Nitrate ...
 5-108 3.63e-03

phosphoacceptor receiver (REC) domain of Nitrate/Nitrite response regulator L (NarL); Nitrate/nitrite response regulator protein NarL contains an N-terminal REC domain and a C-terminal LuxR family helix-turn-helix (HTH) DNA-binding output domain. Escherichia coli NarL activates the expression of the nitrate reductase (narGHJI) and formate dehydrogenase-N (fdnGHI) operons, and represses the transcription of the fumarate reductase (frdABCD) operon in response to a nitrate/nitrite induction signal. Phosphorylation of the NarL REC domain releases the C-terminal HTH output domain that subsequently binds specific DNA promoter sites to repress or activate gene expression. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381158 [Multi-domain]  Cd Length: 117  Bit Score: 36.17  E-value: 3.63e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100   5 ILVVDDDV----AVCELLQdvlSEHVFTVL-TCHTGQDAVNRVQQ-DPGIalVLLDMMLPDINGLQVLLQLQKQRPSLPV 78
Cdd:cd19931    1 VLLIDDHPllrkGIKQLIE---LDPDFTVVgEASSGEEGIELAERlDPDL--ILLDLNMKGMSGLDTLKALREEGVSARI 75

                         90       100       110
                 ....*....|....*....|....*....|
gi 505383100  79 VMLTGLGSESDVVVGLEMGADDYIGKPFNP 108
Cdd:cd19931   76 VILTVSDAEDDVVTALRAGADGYLLKDMEP 105
REC_PdtaR-like cd19932
phosphoacceptor receiver (REC) domain of PdtaR and similar proteins; This subfamily includes ...
 5-106 8.10e-03

phosphoacceptor receiver (REC) domain of PdtaR and similar proteins; This subfamily includes Mycobacterium tuberculosis PdtaR, also called Rv1626, and similar proteins containing a REC domain and an ANTAR (AmiR and NasR transcription antitermination regulators) RNA-binding output domain. PdtaR is a response regulator that acts at the level of transcriptional antitermination and is a member of the PdtaR/PdtaS two-component regulatory system. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381159 [Multi-domain]  Cd Length: 118  Bit Score: 35.47  E-value: 8.10e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100   5 ILVVDDDVAVCELLQDVLSEHVFTVL-TCHTGQDAV---NRVQQDpgiaLVLLDMMLPDINGLQVLLQLQKQRPSlPVVM 80
Cdd:cd19932    3 VLIAEDEALIRMDLREMLEEAGYEVVgEASDGEEAVelaKKHKPD----LVIMDVKMPRLDGIEAAKIITSENIA-PIVL 77

                         90       100
                 ....*....|....*....|....*.
gi 505383100  81 LTGLGSESDVVVGLEMGADDYIGKPF 106
Cdd:cd19932   78 LTAYSQQDLVERAKEAGAMAYLVKPF 103
REC_RocR cd17530
phosphoacceptor receiver (REC) domain of response regulator RocR; The response regulator RocR ...
 5-108 8.40e-03

phosphoacceptor receiver (REC) domain of response regulator RocR; The response regulator RocR from some pathogens contains an N-terminal phosphoreceiver (REC) domain and a C-terminal EAL domain that possesses c-di-GMP specific phosphodiesterase activity. The RocR REC domain is phosphorylated and modulates its EAL domain enzymatic activity, regulating the local level of c-di-GMP. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381086 [Multi-domain]  Cd Length: 123  Bit Score: 35.49  E-value: 8.40e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383100   5 ILVVDDDVAVCELLQDVLSEHVF-TVLTCHTGQDAVNRVQQDpGIALVLLDMMLPDINGLQVLLQLQKQRPSLPVVMLTG 83
Cdd:cd17530    3 VLVLDDDPFQCMMAATILEDLGPgNVDEADDGREALVILLCN-APDIIICDLKMPDMDGIEFLRHLAESHSNAAVILMSG 81

                         90       100       110
                 ....*....|....*....|....*....|
gi 505383100  84 LGS---ESDVVVGLEMGAD--DYIGKPFNP 108
Cdd:cd17530   82 LDGgilESAETLAGANGLNllGTLSKPFSP 111
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH