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Conserved domains on  [gi|505383213|ref|WP_015570315|]
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MULTISPECIES: fatty acid metabolism transcriptional regulator FadR [Enterobacter]

Protein Classification

fatty acid metabolism regulator( domain architecture ID 11480320)

fatty acid metabolism regulator is a dimeric acyl coenzyme A binding protein and GntR family transcription factor that regulates the expression of genes encoding fatty acid biosynthetic and degrading enzymes

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK04984 PRK04984
fatty acid metabolism transcriptional regulator FadR;
1-239 0e+00

fatty acid metabolism transcriptional regulator FadR;


:

Pssm-ID: 179909 [Multi-domain]  Cd Length: 239  Bit Score: 519.81  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383213   1 MVIKAQSPAGFAEEYIIESIWNNRFPAGSILPAERELSELIGVTRTTLREVLQRLARDGWLTIQHGKPTKVNNFWETSGL 80
Cdd:PRK04984   1 MVIKAQSPAGFAEEYIIESIWNNRFPPGSILPAERELSELIGVTRTTLREVLQRLARDGWLTIQHGKPTKVNNFWETSGL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383213  81 NILETLARLDHESVPQLIDNLLSVRTNIATIFIRTAFRQHPEDALKVLATANEVEDHADAFATLDYNVFRGLAFASGNPV 160
Cdd:PRK04984  81 NILETLARLDHDSVPQLIDNLLSARTNISAIFIRTAFRNNPEKALEVLATAEELEDTAEAFAEFDYNLFRGLAFASGNPI 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 505383213 161 YGLILNGMKGLYTRIGRHYFANPEARSLALGFYHKLSKLCTEGLHDQVYETVRRYGHDSGEIWHRMQKTLPGDLAIQSR 239
Cdd:PRK04984 161 YGLILNGLKGLYTRVGRYYFSNPEARELALGFYHKLSALCEEGNHDQVPECVRQYGIESGEIWHRMQKNLPGDLAEQGR 239
 
Name Accession Description Interval E-value
PRK04984 PRK04984
fatty acid metabolism transcriptional regulator FadR;
1-239 0e+00

fatty acid metabolism transcriptional regulator FadR;


Pssm-ID: 179909 [Multi-domain]  Cd Length: 239  Bit Score: 519.81  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383213   1 MVIKAQSPAGFAEEYIIESIWNNRFPAGSILPAERELSELIGVTRTTLREVLQRLARDGWLTIQHGKPTKVNNFWETSGL 80
Cdd:PRK04984   1 MVIKAQSPAGFAEEYIIESIWNNRFPPGSILPAERELSELIGVTRTTLREVLQRLARDGWLTIQHGKPTKVNNFWETSGL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383213  81 NILETLARLDHESVPQLIDNLLSVRTNIATIFIRTAFRQHPEDALKVLATANEVEDHADAFATLDYNVFRGLAFASGNPV 160
Cdd:PRK04984  81 NILETLARLDHDSVPQLIDNLLSARTNISAIFIRTAFRNNPEKALEVLATAEELEDTAEAFAEFDYNLFRGLAFASGNPI 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 505383213 161 YGLILNGMKGLYTRIGRHYFANPEARSLALGFYHKLSKLCTEGLHDQVYETVRRYGHDSGEIWHRMQKTLPGDLAIQSR 239
Cdd:PRK04984 161 YGLILNGLKGLYTRVGRYYFSNPEARELALGFYHKLSALCEEGNHDQVPECVRQYGIESGEIWHRMQKNLPGDLAEQGR 239
fadR_gamma TIGR02812
fatty acid metabolism transcriptional regulator FadR; Members of this family are FadR, a ...
 2-236 5.52e-167

fatty acid metabolism transcriptional regulator FadR; Members of this family are FadR, a transcriptional regulator of fatty acid metabolism, including both biosynthesis and beta-oxidation. It is found exclusively in a subset of Gammaproteobacteria, with strictly one copy per genome. It has an N-terminal DNA-binding domain and a less well conserved C-terminal long chain acyl-CoA-binding domain. FadR from this family heterologously expressed in Escherichia coli show differences in regulatory response and fatty acid binding profiles. The family is nevertheless designated equivalog, as all member proteins have at least nominally the same function. [Fatty acid and phospholipid metabolism, Biosynthesis, Fatty acid and phospholipid metabolism, Degradation, Regulatory functions, DNA interactions]


Pssm-ID: 163028 [Multi-domain]  Cd Length: 235  Bit Score: 459.90  E-value: 5.52e-167
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383213    2 VIKAQSPAGFAEEYIIESIWNNRFPAGSILPAERELSELIGVTRTTLREVLQRLARDGWLTIQHGKPTKVNNFWETSGLN 81
Cdd:TIGR02812   1 VIKAKSPAGFAEEYIVESIWNNRFPPGSILPAERELSELIGVTRTTLREVLQRLARDGWLTIQHGKPTKVNNFWETSGLN 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383213   82 ILETLARLDHESVPQLIDNLLSVRTNIATIFIRTAFRQHPEDALKVLATANEVEDHADAFATLDYNVFRGLAFASGNPVY 161
Cdd:TIGR02812  81 ILETLIRLDGESVPSLIDNLLSARTNISAIYIRYAFKNNPEKALEVLANANELEDTAEAFTEFDYQLFRGLAFASGNPIY 160

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 505383213  162 GLILNGMKGLYTRIGRHYFANPEARSLALGFYHKLSKLCTEGLHDQVYETVRRYGHDSGEIWHRMQKTLPGDLAI 236
Cdd:TIGR02812 161 GLILNGLKGLYTRIGRYYFANPEARELALQFYKELQALCKAGNHDEVPDCIRQYGIESGEIWHQMQDELPQDLSE 235
FadR_C pfam07840
FadR C-terminal domain; This family contains sequences that are similar to the fatty acid ...
 72-234 8.32e-101

FadR C-terminal domain; This family contains sequences that are similar to the fatty acid metabolism regulator protein (FadR). This functions as a dimer, with each monomer being composed of an N-terminal DNA-binding domain and a regulatory C-terminal domain. A linker comprising two short alpha helices joins the two domains. In the C-terminal domain, an antiparallel array of six alpha helices forms a barrel-like structure, while a seventh alpha helix forms a 'lid' at the end closest to the N-terminal domain. This structure was found to be similar to that of the C-terminal domain of the Tet repressor. Long-chain acyl-CoA thioesters interact directly and reversibly with the C-terminal domain, and this interaction affects the structure and therefore the DNA binding properties of the N-terminal domain.


Pssm-ID: 429691  Cd Length: 163  Bit Score: 289.93  E-value: 8.32e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383213   72 NNFWETSGLNILETLARLDHESVPQLIDNLLSVRTNIATIFIRTAFRQHPEDALKVLATANEVEDHADAFATLDYNVFRG 151
Cdd:pfam07840   1 NNFWETSGLNILETLARLDEDSVPDLIDNLLSARTNISAIYIREAIKNNPEKSLEVLAQLDELEDTAEAFAEFDYNLFHG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383213  152 LAFASGNPVYGLILNGMKGLYTRIGRHYFANPEARSLALGFYHKLSKLCTEGLHDQVYETVRRYGHDSGEIWHRMQKTLP 231
Cdd:pfam07840  81 LAFASGNPIYVLILNGFKGLYSRVGRYYFSNPEARELALQFYRELLQLCEEGNYDQVMDVVRKYGKESGEIWHSMRLDLP 160


                  ...
gi 505383213  232 GDL 234
Cdd:pfam07840 161 SNF 163
FadR COG2186
DNA-binding transcriptional regulator, FadR family [Transcription];
3-196 6.17e-42

DNA-binding transcriptional regulator, FadR family [Transcription];


Pssm-ID: 441789 [Multi-domain]  Cd Length: 232  Bit Score: 142.38  E-value: 6.17e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383213   3 IKAQSPAGFAEEYIIESIWNNRFPAGSILPAERELSELIGVTRTTLREVLQRLARDGWLTIQHGKPTKVNNFWETSGLNI 82
Cdd:COG2186    3 IRRRSLAEQVAEQLRELILSGELKPGDRLPSERELAEQLGVSRTTVREALRALEALGLVEVRQGGGTFVREPSPWALLDP 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383213  83 LETLARLDHESvpqlIDNLLSVRTNIATIFIRTAFRQHPEDALKVLATANEVEDHA----DAFATLDYNVFRGLAFASGN 158
Cdd:COG2186   83 LALLLALDDAS----LRDLLEARLALEPEAARLAAERATDEDLARLEAALAEMEAAaddgEAFAEADLAFHRAIAEASGN 158

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 505383213 159 PVYGLILNGMKGLYTRIGRHYFANPEARSLALGFYHKL 196
Cdd:COG2186  159 PLLALLLESLRELLRRSVRLTLRSPEARERSLAEHRAI 196
HTH_GNTR smart00345
helix_turn_helix gluconate operon transcriptional repressor;
12-71 1.60e-18

helix_turn_helix gluconate operon transcriptional repressor;


Pssm-ID: 197669 [Multi-domain]  Cd Length: 60  Bit Score: 76.46  E-value: 1.60e-18
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383213    12 AEEYIIESIWNNRFPAGSILPAERELSELIGVTRTTLREVLQRLARDGWLTIQHGKPTKV 71
Cdd:smart00345   1 VAERLREDIVSGELRPGDKLPSERELAAQLGVSRTTVREALSRLEAEGLVQRRPGSGTFV 60
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 14-72 2.03e-16

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 70.94  E-value: 2.03e-16
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 505383213  14 EYIIESIWNNRFPAGSILPAERELSELIGVTRTTLREVLQRLARDGWLTIQHGKPTKVN 72
Cdd:cd07377    8 DQLREAILSGELKPGDRLPSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFVA 66
 
Name Accession Description Interval E-value
PRK04984 PRK04984
fatty acid metabolism transcriptional regulator FadR;
1-239 0e+00

fatty acid metabolism transcriptional regulator FadR;


Pssm-ID: 179909 [Multi-domain]  Cd Length: 239  Bit Score: 519.81  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383213   1 MVIKAQSPAGFAEEYIIESIWNNRFPAGSILPAERELSELIGVTRTTLREVLQRLARDGWLTIQHGKPTKVNNFWETSGL 80
Cdd:PRK04984   1 MVIKAQSPAGFAEEYIIESIWNNRFPPGSILPAERELSELIGVTRTTLREVLQRLARDGWLTIQHGKPTKVNNFWETSGL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383213  81 NILETLARLDHESVPQLIDNLLSVRTNIATIFIRTAFRQHPEDALKVLATANEVEDHADAFATLDYNVFRGLAFASGNPV 160
Cdd:PRK04984  81 NILETLARLDHDSVPQLIDNLLSARTNISAIFIRTAFRNNPEKALEVLATAEELEDTAEAFAEFDYNLFRGLAFASGNPI 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 505383213 161 YGLILNGMKGLYTRIGRHYFANPEARSLALGFYHKLSKLCTEGLHDQVYETVRRYGHDSGEIWHRMQKTLPGDLAIQSR 239
Cdd:PRK04984 161 YGLILNGLKGLYTRVGRYYFSNPEARELALGFYHKLSALCEEGNHDQVPECVRQYGIESGEIWHRMQKNLPGDLAEQGR 239
fadR_gamma TIGR02812
fatty acid metabolism transcriptional regulator FadR; Members of this family are FadR, a ...
 2-236 5.52e-167

fatty acid metabolism transcriptional regulator FadR; Members of this family are FadR, a transcriptional regulator of fatty acid metabolism, including both biosynthesis and beta-oxidation. It is found exclusively in a subset of Gammaproteobacteria, with strictly one copy per genome. It has an N-terminal DNA-binding domain and a less well conserved C-terminal long chain acyl-CoA-binding domain. FadR from this family heterologously expressed in Escherichia coli show differences in regulatory response and fatty acid binding profiles. The family is nevertheless designated equivalog, as all member proteins have at least nominally the same function. [Fatty acid and phospholipid metabolism, Biosynthesis, Fatty acid and phospholipid metabolism, Degradation, Regulatory functions, DNA interactions]


Pssm-ID: 163028 [Multi-domain]  Cd Length: 235  Bit Score: 459.90  E-value: 5.52e-167
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383213    2 VIKAQSPAGFAEEYIIESIWNNRFPAGSILPAERELSELIGVTRTTLREVLQRLARDGWLTIQHGKPTKVNNFWETSGLN 81
Cdd:TIGR02812   1 VIKAKSPAGFAEEYIVESIWNNRFPPGSILPAERELSELIGVTRTTLREVLQRLARDGWLTIQHGKPTKVNNFWETSGLN 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383213   82 ILETLARLDHESVPQLIDNLLSVRTNIATIFIRTAFRQHPEDALKVLATANEVEDHADAFATLDYNVFRGLAFASGNPVY 161
Cdd:TIGR02812  81 ILETLIRLDGESVPSLIDNLLSARTNISAIYIRYAFKNNPEKALEVLANANELEDTAEAFTEFDYQLFRGLAFASGNPIY 160

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 505383213  162 GLILNGMKGLYTRIGRHYFANPEARSLALGFYHKLSKLCTEGLHDQVYETVRRYGHDSGEIWHRMQKTLPGDLAI 236
Cdd:TIGR02812 161 GLILNGLKGLYTRIGRYYFANPEARELALQFYKELQALCKAGNHDEVPDCIRQYGIESGEIWHQMQDELPQDLSE 235
FadR_C pfam07840
FadR C-terminal domain; This family contains sequences that are similar to the fatty acid ...
 72-234 8.32e-101

FadR C-terminal domain; This family contains sequences that are similar to the fatty acid metabolism regulator protein (FadR). This functions as a dimer, with each monomer being composed of an N-terminal DNA-binding domain and a regulatory C-terminal domain. A linker comprising two short alpha helices joins the two domains. In the C-terminal domain, an antiparallel array of six alpha helices forms a barrel-like structure, while a seventh alpha helix forms a 'lid' at the end closest to the N-terminal domain. This structure was found to be similar to that of the C-terminal domain of the Tet repressor. Long-chain acyl-CoA thioesters interact directly and reversibly with the C-terminal domain, and this interaction affects the structure and therefore the DNA binding properties of the N-terminal domain.


Pssm-ID: 429691  Cd Length: 163  Bit Score: 289.93  E-value: 8.32e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383213   72 NNFWETSGLNILETLARLDHESVPQLIDNLLSVRTNIATIFIRTAFRQHPEDALKVLATANEVEDHADAFATLDYNVFRG 151
Cdd:pfam07840   1 NNFWETSGLNILETLARLDEDSVPDLIDNLLSARTNISAIYIREAIKNNPEKSLEVLAQLDELEDTAEAFAEFDYNLFHG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383213  152 LAFASGNPVYGLILNGMKGLYTRIGRHYFANPEARSLALGFYHKLSKLCTEGLHDQVYETVRRYGHDSGEIWHRMQKTLP 231
Cdd:pfam07840  81 LAFASGNPIYVLILNGFKGLYSRVGRYYFSNPEARELALQFYRELLQLCEEGNYDQVMDVVRKYGKESGEIWHSMRLDLP 160


                  ...
gi 505383213  232 GDL 234
Cdd:pfam07840 161 SNF 163
FadR COG2186
DNA-binding transcriptional regulator, FadR family [Transcription];
3-196 6.17e-42

DNA-binding transcriptional regulator, FadR family [Transcription];


Pssm-ID: 441789 [Multi-domain]  Cd Length: 232  Bit Score: 142.38  E-value: 6.17e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383213   3 IKAQSPAGFAEEYIIESIWNNRFPAGSILPAERELSELIGVTRTTLREVLQRLARDGWLTIQHGKPTKVNNFWETSGLNI 82
Cdd:COG2186    3 IRRRSLAEQVAEQLRELILSGELKPGDRLPSERELAEQLGVSRTTVREALRALEALGLVEVRQGGGTFVREPSPWALLDP 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383213  83 LETLARLDHESvpqlIDNLLSVRTNIATIFIRTAFRQHPEDALKVLATANEVEDHA----DAFATLDYNVFRGLAFASGN 158
Cdd:COG2186   83 LALLLALDDAS----LRDLLEARLALEPEAARLAAERATDEDLARLEAALAEMEAAaddgEAFAEADLAFHRAIAEASGN 158

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 505383213 159 PVYGLILNGMKGLYTRIGRHYFANPEARSLALGFYHKL 196
Cdd:COG2186  159 PLLALLLESLRELLRRSVRLTLRSPEARERSLAEHRAI 196
GntR pfam00392
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the ...
 8-71 1.21e-19

Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerization domain. The GntR-like proteins include the following sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA, DevA, DasR. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships. The DasR regulator has been shown to be a global regulator of primary metabolism and development in Streptomyces coelicolor.


Pssm-ID: 306822 [Multi-domain]  Cd Length: 64  Bit Score: 79.58  E-value: 1.21e-19
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 505383213    8 PAGFAEEYIIESIWNNRFPAGSILPAERELSELIGVTRTTLREVLQRLARDGWLTIQHGKPTKV 71
Cdd:pfam00392   1 LYEQVYARLREDILSGRLRPGDKLPSERELAAEFGVSRTTVREALRRLEAEGLVERRQGRGTFV 64
HTH_GNTR smart00345
helix_turn_helix gluconate operon transcriptional repressor;
12-71 1.60e-18

helix_turn_helix gluconate operon transcriptional repressor;


Pssm-ID: 197669 [Multi-domain]  Cd Length: 60  Bit Score: 76.46  E-value: 1.60e-18
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383213    12 AEEYIIESIWNNRFPAGSILPAERELSELIGVTRTTLREVLQRLARDGWLTIQHGKPTKV 71
Cdd:smart00345   1 VAERLREDIVSGELRPGDKLPSERELAAQLGVSRTTVREALSRLEAEGLVQRRPGSGTFV 60
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 14-72 2.03e-16

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 70.94  E-value: 2.03e-16
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 505383213  14 EYIIESIWNNRFPAGSILPAERELSELIGVTRTTLREVLQRLARDGWLTIQHGKPTKVN 72
Cdd:cd07377    8 DQLREAILSGELKPGDRLPSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFVA 66
GntR COG1802
DNA-binding transcriptional regulator, GntR family [Transcription];
3-190 9.66e-14

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441407 [Multi-domain]  Cd Length: 222  Bit Score: 68.03  E-value: 9.66e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383213   3 IKAQSPAGFAEEYIIESIWNNRFPAGSILPaERELSELIGVTRTTLREVLQRLARDGWLTIQHGKPTKVnnfwetsglni 82
Cdd:COG1802    7 LRRESLAEQVYEALREAILSGELPPGERLS-EAELAERLGVSRTPVREALRRLEAEGLVEIRPNRGARV----------- 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383213  83 letlARLDHESVPQLIDnllsVRTNIATIFIRTAFRQHPEDALKVLATANEVEDHA------DAFATLDYNVFRGLAFAS 156
Cdd:COG1802   75 ----APLSPEEIRELYE----VRAALEGLAARLAAERATPADLARLRALLEELEAAaaagdvAAYLELDREFHRALVEAA 146

                        170       180       190
                 ....*....|....*....|....*....|....
gi 505383213 157 GNPVYGLILNGMKGLYTRIGRHYFANPEARSLAL 190
Cdd:COG1802  147 GNPRLAELLRRLRARLRRYRRLSLRSPGRLEESL 180
PRK03837 PRK03837
transcriptional regulator NanR; Provisional
 13-168 2.31e-12

transcriptional regulator NanR; Provisional


Pssm-ID: 235166 [Multi-domain]  Cd Length: 241  Bit Score: 64.27  E-value: 2.31e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383213  13 EEYIIESIWNNRFPAGSILPAERELSELIGVTRTTLREVLQRLARDGWLTIQHGKPTKVNNFWETSGLNILETLARLDHE 92
Cdd:PRK03837  19 EERLEQMIRSGEFGPGDQLPSERELMAFFGVGRPAVREALQALKRKGLVQISHGERARVSRPSADTIIGQLSGMAKDFLS 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383213  93 SVPQLIDNLLSVRTNIATIFIRTAFRQHPEDALKVLATANEVEDHA----DAFATLDYNVFRGLAFASGNPVYGLILNGM 168
Cdd:PRK03837  99 QSPDGLAHLKQARLFFESSLARYAAEHATDEQIALLRKALERNSQSlgdnAAFIRSDMEFHRVIAEIPGNPIFMAIHEAL 178
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
13-125 6.75e-12

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 62.96  E-value: 6.75e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383213  13 EEYIIESIWNNRFPAGSILPAERELSELIGVTRTTLREVLQRLARDGWLTIQHGKPTKVNNFWETSGL----NILETLAR 88
Cdd:COG2188   11 ADALRERIESGELPPGDRLPSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAEPKIEYPLsrltSFTEELRA 90

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 505383213  89 LDHESVPQlidnLLSVRTNIATIFIRTAFRQHPEDAL 125
Cdd:COG2188   91 RGREPSTR----VLSAERVPADEEVAEALGLPPGAPV 123
PRK10421 PRK10421
DNA-binding transcriptional repressor LldR; Provisional
 27-173 2.79e-09

DNA-binding transcriptional repressor LldR; Provisional


Pssm-ID: 236690 [Multi-domain]  Cd Length: 253  Bit Score: 55.93  E-value: 2.79e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383213  27 AGSILPAERELSELIGVTRTTLREVLQRLARDGWLTIQHGKPTKVNNFWET-SGLNILETLARLdHESVPQLIDNLLSVR 105
Cdd:PRK10421  22 AGMKLPAERQLAMQLGVSRNSLREALAKLVSEGVLLSRRGGGTFIRWRHETwSEQNIVQPLKTL-MADDPDYSFDILEAR 100

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383213 106 TNI-ATIFIRTAFRQHPEDALKVLATANEV-EDHADAFATLDYNVFRGLAFASGNPVyglILNGMKGLYT 173
Cdd:PRK10421 101 HAIeASTAWHAAMRATPGDKEKIQLCFEATlSEDPDLASQADVRFHLAIAEASHNVV---LLQTMRGFFD 167
ARO8 COG1167
DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain ...
 14-73 2.12e-08

DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain [Transcription, Amino acid transport and metabolism]; DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain is part of the Pathway/BioSystem: Lysine biosynthesis


Pssm-ID: 440781 [Multi-domain]  Cd Length: 471  Bit Score: 54.06  E-value: 2.12e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383213  14 EYIIESIWNNRFPAGSILPAERELSELIGVTRTTLREVLQRLARDGWLTIQHGKPTKVNN 73
Cdd:COG1167   19 DALREAILSGRLPPGDRLPSSRELAAQLGVSRSTVVRAYEELEAEGLIESRPGSGTFVAA 78
pdhR PRK09464
pyruvate dehydrogenase complex transcriptional repressor PdhR;
28-135 5.84e-06

pyruvate dehydrogenase complex transcriptional repressor PdhR;


Pssm-ID: 181879 [Multi-domain]  Cd Length: 254  Bit Score: 46.17  E-value: 5.84e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383213  28 GSILPAERELSELIGVTRTTLREVLQRLARDGWLTIQHGKPTKV-NNFWETSGLNILETLARlDHESvpQLidNLLSVR- 105
Cdd:PRK09464  31 GEKLPPERELAKQFDVSRPSLREAIQRLEAKGLLLRRQGGGTFVqSSLWQSFSDPLVELLSD-HPES--QF--DLLETRh 105

                         90       100       110
                 ....*....|....*....|....*....|..
gi 505383213 106 --TNIATIFirTAFRQHPEDALKVLATANEVE 135
Cdd:PRK09464 106 alEGIAAYY--AALRGTDEDFERIRECHHAIE 135
PRK11402 PRK11402
transcriptional regulator PhoB;
16-71 7.11e-06

transcriptional regulator PhoB;


Pssm-ID: 183118 [Multi-domain]  Cd Length: 241  Bit Score: 45.60  E-value: 7.11e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 505383213  16 IIESIWNNRFPAGSILPAERELSELIGVTRTTLREVLQRLARDGWLTIQHGKPTKV 71
Cdd:PRK11402  18 LLDDIAQGVYQAGQQIPTENELCTQYNVSRITIRKAISDLVADGVLIRWQGKGTFV 73
PRK09990 PRK09990
DNA-binding transcriptional regulator GlcC; Provisional
 27-160 3.78e-05

DNA-binding transcriptional regulator GlcC; Provisional


Pssm-ID: 182186 [Multi-domain]  Cd Length: 251  Bit Score: 43.60  E-value: 3.78e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383213  27 AGSILPAERELSELIGVTRTTLREVLQRLARDGWLTIQHGKPTKVNNfwetsgLNILETLARLDH--ESVPQLIDNLLSV 104
Cdd:PRK09990  27 VGQALPSERRLCEKLGFSRSALREGLTVLRGRGIIETAQGRGSFVAR------LNRVQDASPLMHlfSSQPRTLYDLLEV 100

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 505383213 105 RTNIATIFIR-TAFRQHPEDAL-------KVLATANEVEDHADA-FATLDYNVFRGLAFASGNPV 160
Cdd:PRK09990 101 RALLEGESARlAALRGTQADFVlitrryeEMLAAHENNKEIDPIeHARLDHAFHLAICEASHNPV 165
C_P_lyase_phnF TIGR02325
phosphonates metabolism transcriptional regulator PhnF; All members of the seed alignment for ...
 13-71 5.48e-05

phosphonates metabolism transcriptional regulator PhnF; All members of the seed alignment for this family are predicted helix-turn-helix transcriptional regulatory proteins of the broader gntR and are found associated with genes for the import and degradation of phosphonates and/or related compounds (e.g. phosphonites) with a direct C-P bond. [Transport and binding proteins, Anions, Regulatory functions, DNA interactions]


Pssm-ID: 131378 [Multi-domain]  Cd Length: 238  Bit Score: 43.23  E-value: 5.48e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 505383213   13 EEYIIESIWNNRFPAGSILPAERELSELIGVTRTTLREVLQRLARDGWLTIQHGKPTKV 71
Cdd:TIGR02325  14 ADKIEQEIAAGHLRAGDYLPAEMQLAERFGVNRHTVRRAIAALVERGLLRAEQGRGTFV 72
TrmB pfam01978
Sugar-specific transcriptional regulator TrmB; One member of this family, TrmB, has been shown ...
 35-70 1.11e-04

Sugar-specific transcriptional regulator TrmB; One member of this family, TrmB, has been shown to be a sugar-specific transcriptional regulator of the trehalose/maltose ABC transporter in Thermococcus litoralis.


Pssm-ID: 396525 [Multi-domain]  Cd Length: 67  Bit Score: 39.43  E-value: 1.11e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 505383213   35 RELSELIGVTRTTLREVLQRLARDGWLTIQHGKPTK 70
Cdd:pfam01978  26 DEIAEESGVPRSKVYEVLRSLEDKGLVEREKGRPKK 61
PRK10225 PRK10225
Uxu operon transcriptional regulator;
28-127 2.69e-04

Uxu operon transcriptional regulator;


Pssm-ID: 182318 [Multi-domain]  Cd Length: 257  Bit Score: 41.16  E-value: 2.69e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505383213  28 GSILPAERELSELIGVTRTTLREVLQRLARDGWLTIQHGkptkvnnfwetSGLNILETLARLDHESVPQLIDN------L 101
Cdd:PRK10225  30 GERLPPEREIAEMLDVTRTVVREALIMLEIKGLVEVRRG-----------AGIYVLDSSGSHNTDSPDANVCNdagpfeL 98

                         90       100       110
                 ....*....|....*....|....*....|
gi 505383213 102 LSVR----TNIATIFIRTAFRqhpEDALKV 127
Cdd:PRK10225  99 LQARqlleSNIAEFAALQATR---EDIVKM 125
YrhO COG1378
Sugar-specific transcriptional regulator TrmB [Transcription];
35-70 3.64e-04

Sugar-specific transcriptional regulator TrmB [Transcription];


Pssm-ID: 440988 [Multi-domain]  Cd Length: 238  Bit Score: 40.77  E-value: 3.64e-04
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 505383213  35 RELSELIGVTRTTLREVLQRLARDGWLTIQHGKPTK 70
Cdd:COG1378   31 SELAKASGVPRSRVYDVLESLEEKGLVEVSEGRPKR 66
LexA COG1974
SOS-response transcriptional repressor LexA (RecA-mediated autopeptidase) [Transcription, ...
 14-68 9.36e-04

SOS-response transcriptional repressor LexA (RecA-mediated autopeptidase) [Transcription, Signal transduction mechanisms];


Pssm-ID: 441577 [Multi-domain]  Cd Length: 199  Bit Score: 39.13  E-value: 9.36e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 505383213  14 EYIIESIWNNRFPagsilPAERELSELIGVTRTTLREVLQRLARDGWLTIQHGKP 68
Cdd:COG1974   13 DFIKEYIRERGYP-----PSQREIAEALGLSSSAVHRHLKALEKKGYLRRDPGKS 62
HTH_CRP smart00419
helix_turn_helix, cAMP Regulatory protein;
35-67 1.76e-03

helix_turn_helix, cAMP Regulatory protein;


Pssm-ID: 128696 [Multi-domain]  Cd Length: 48  Bit Score: 35.49  E-value: 1.76e-03
                           10        20        30
                   ....*....|....*....|....*....|...
gi 505383213    35 RELSELIGVTRTTLREVLQRLARDGWLTIQHGK 67
Cdd:smart00419  12 QEIAELLGLTRETVSRTLKRLEKEGLISREGGR 44
PRK11523 PRK11523
transcriptional regulator ExuR;
18-66 2.28e-03

transcriptional regulator ExuR;


Pssm-ID: 183176 [Multi-domain]  Cd Length: 253  Bit Score: 38.29  E-value: 2.28e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 505383213  18 ESIWNNRFPAGSILPAERELSELIGVTRTTLREVLQRLARDGWLTIQHG 66
Cdd:PRK11523  19 ERIEQGVYLVGDKLPAERFIADEKNVSRTVVREAIIMLEVEGYVEVRKG 67
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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