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Conserved domains on  [gi|505384730|ref|WP_015571832|]
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MULTISPECIES: galactose/proton symporter [Enterobacter]

Protein Classification

sugar porter family MFS transporter( domain architecture ID 11489872)

sugar porter family major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of sugar or polyol substrates such as glucose, galactose, trehalose, and arabinose, among others

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
SCOP:  3000310
TCDB:  2.A.1.1

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
SP TIGR00879
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of ...
11-448 6.59e-150

MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of the major facilitator superfamily (pfam00083) [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


:

Pssm-ID: 273317 [Multi-domain]  Cd Length: 481  Bit Score: 435.61  E-value: 6.59e-150
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730   11 SNKAMTFFVCFLAALAGLLFGLDIGVIAGALPFITDEFQI--------SAHTQEWVVSSMMFGAAVGAVGSGWLSFKLGR 82
Cdd:TIGR00879  21 STYWKVALLSLIAAIGGLMFGYDTGVIGGALALPAFEFKFtsansdsySSSLWGLVVSIFLVGGFIGALFAGWLSDRFGR 100
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730   83 KKSLMIGAILFVAGSLFSAAAPN---VEVLIISRVLLGLAVGVASYTAPLYLSEIAPEKIRGSMISMYQLMITIGILGAY 159
Cdd:TIGR00879 101 KKSLLIIALLFVIGAILMGLAAFalsVEMLIVGRVLLGIGVGIASALVPMYLSEIAPKALRGALTSLYQLAITFGILVAY 180
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  160 LSDTA---FSYSGAWRWMLGVIIIPAILLLIGVFFLPDSPRWFAAKRRFHDAERVLLRLRDTSAEAKNELEEIR------ 230
Cdd:TIGR00879 181 GFGSGkvsLNNTLGWRIPLGLQLIPAGLLFLGLFFLPESPRWLVGKGRVEEARKSLARLRGTSGEDKELLDELElidikr 260
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  231 --ESLKVKQSGWALFKENSNFRRAVFLGVLLQIMQQFTGMNVIMYYAPKIFELAGYTNTTeQMWGTVIVGLTNVLATFIA 308
Cdd:TIGR00879 261 siEKRSVQPSWGSLFSSTRRIRRRLFLGVVLQWFQQFTGINAIMYYSPTIFENAGVSTDH-AFLVSIIVGAVNFAFTFVA 339
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  309 IGLVDRWGRKPTLTLGFLVMAVGMGVLGTMMHMGIH--SPTAQYFAVAMLLMFIIGFAMSAGPLIWVLCSEIQPLKGRDF 386
Cdd:TIGR00879 340 IFLVDRFGRRPLLLIGAAGMAICLFVLGILGASFVTgsSKSSGNVAIVFILLFIAFFAMGWGPVPWVIVSEIFPLSLRPK 419
                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 505384730  387 GITCSTATNWIANMIVGATFLTMLNTLGNANTFWVYAGLNLFFIVLTIWLVPETKHVSLEHI 448
Cdd:TIGR00879 420 GISIAVAANWLANFIVGFLFPTMLESIGVGGVFIFFGGLNVLGLIFVYFFLPETKGRTLEEI 481
 
Name Accession Description Interval E-value
SP TIGR00879
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of ...
11-448 6.59e-150

MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of the major facilitator superfamily (pfam00083) [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273317 [Multi-domain]  Cd Length: 481  Bit Score: 435.61  E-value: 6.59e-150
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730   11 SNKAMTFFVCFLAALAGLLFGLDIGVIAGALPFITDEFQI--------SAHTQEWVVSSMMFGAAVGAVGSGWLSFKLGR 82
Cdd:TIGR00879  21 STYWKVALLSLIAAIGGLMFGYDTGVIGGALALPAFEFKFtsansdsySSSLWGLVVSIFLVGGFIGALFAGWLSDRFGR 100
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730   83 KKSLMIGAILFVAGSLFSAAAPN---VEVLIISRVLLGLAVGVASYTAPLYLSEIAPEKIRGSMISMYQLMITIGILGAY 159
Cdd:TIGR00879 101 KKSLLIIALLFVIGAILMGLAAFalsVEMLIVGRVLLGIGVGIASALVPMYLSEIAPKALRGALTSLYQLAITFGILVAY 180
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  160 LSDTA---FSYSGAWRWMLGVIIIPAILLLIGVFFLPDSPRWFAAKRRFHDAERVLLRLRDTSAEAKNELEEIR------ 230
Cdd:TIGR00879 181 GFGSGkvsLNNTLGWRIPLGLQLIPAGLLFLGLFFLPESPRWLVGKGRVEEARKSLARLRGTSGEDKELLDELElidikr 260
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  231 --ESLKVKQSGWALFKENSNFRRAVFLGVLLQIMQQFTGMNVIMYYAPKIFELAGYTNTTeQMWGTVIVGLTNVLATFIA 308
Cdd:TIGR00879 261 siEKRSVQPSWGSLFSSTRRIRRRLFLGVVLQWFQQFTGINAIMYYSPTIFENAGVSTDH-AFLVSIIVGAVNFAFTFVA 339
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  309 IGLVDRWGRKPTLTLGFLVMAVGMGVLGTMMHMGIH--SPTAQYFAVAMLLMFIIGFAMSAGPLIWVLCSEIQPLKGRDF 386
Cdd:TIGR00879 340 IFLVDRFGRRPLLLIGAAGMAICLFVLGILGASFVTgsSKSSGNVAIVFILLFIAFFAMGWGPVPWVIVSEIFPLSLRPK 419
                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 505384730  387 GITCSTATNWIANMIVGATFLTMLNTLGNANTFWVYAGLNLFFIVLTIWLVPETKHVSLEHI 448
Cdd:TIGR00879 420 GISIAVAANWLANFIVGFLFPTMLESIGVGGVFIFFGGLNVLGLIFVYFFLPETKGRTLEEI 481
Sugar_tr pfam00083
Sugar (and other) transporter;
19-452 1.35e-139

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 408.20  E-value: 1.35e-139
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730   19 VCFLAALAGLLFGLDIGVIAGALPFI--TDEFQISAHTQE---------WVVSSMMFGAAVGAVGSGWLSFKLGRKKSLM 87
Cdd:pfam00083   1 VALVAALGGFLFGYDTGVIGAFLTLIdfFKNFGLSKSVSSlaalsvlsgLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730   88 IGAILFVAGSLFSAAAP---NVEVLIISRVLLGLAVGVASYTAPLYLSEIAPEKIRGSMISMYQLMITIGILGAYLSDTA 164
Cdd:pfam00083  81 IANVLFVIGAVLQGAAKgkwSVYQLIVGRVLVGIGVGGASVLAPMYISEIAPKKLRGALGSLYQLAITFGILLAYIFGLG 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  165 FSYSGA---WRWMLGVIIIPAILLLIGVFFLPDSPRWFAAKRRFHDAERVLLRLR---DTSAEAKNELEEIRESLKVKQS 238
Cdd:pfam00083 161 LNKTSNsdgWRIPLGLQLVPALLLIIGLLFLPESPRWLVEKGRLEEAREVLAKLRgvpDVDRELDEIKDSLEAGQEAEKA 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  239 GWALFKENSNFRRAVFLGVLLQIMQQFTGMNVIMYYAPKIFELAGYTNTteqMWGTVIVGLTNVLATFIAIGLVDRWGRK 318
Cdd:pfam00083 241 SWKELFSTKTRRQRLLIGVMLQIFQQLTGINAIFYYSTTIFENLGLSDS---FLVTIIVGVVNFVFTFIAIFLVDRFGRR 317
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  319 PTLTLGFLVMAVGMGVLGTMMHMGIH-SPTAQYFAVAMLLMFIIGFAMSAGPLIWVLCSEIQPLKGRDFGITCSTATNWI 397
Cdd:pfam00083 318 PLLLLGAAGMAICFVILGIVALLGVSkSDWAGIVAIVFIALFIAFFAMGWGPVPWVIVSELFPLSVRSKAMALATAANWL 397
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 505384730  398 ANMIVGATFLTMLNTLGNANTFWVYAGLNLFFIVLTIWLVPETKHVSLEHIERNL 452
Cdd:pfam00083 398 ANFLIGFLFPIITDAIGLGYTFFIFAGLLVLFIIFVFFFVPETKGRTLEEIDELF 452
MFS_GLUT_like cd17315
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ...
22-439 9.32e-133

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340873 [Multi-domain]  Cd Length: 365  Bit Score: 387.70  E-value: 9.32e-133
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  22 LAALAGLLFGLDIGVIAGALPFITDEFQISAHT--QEWVVSSMMFGAAVGAVGSGWLSFKLGRKKSLMIGAILFVAGSLF 99
Cdd:cd17315    1 VAALGGLLFGYDLGVINGALLYIAKDLGFGLSTslQGLVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 100 SAAAPNVEVLIISRVLLGLAVGVASYTAPLYLSEIAPEKIRGSMISMYQLMITIGILGAYLSDTAFSYS--GAWRWMLGV 177
Cdd:cd17315   81 SALAPNVWVLIVGRFLLGLGVGLASVLVPLYISEIAPAKIRGALGTLNQLMITFGILLAYLLGLALSLSppGWWRLMFAL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 178 IIIPAILLLIGVFFLPDSprwfaakrrfhdaervllrlrdtsaeakneleeireslkvkqsgwalfkensnfrRAVFLGV 257
Cdd:cd17315  161 AAVPALLQLLLMFFLPES-------------------------------------------------------RALLVGV 185
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 258 LLQIMQQFTGMNVIMYYAPKIFELAGytNTTEQMWGTVIVGLTNVLATFIAIGLVDRWGRKPTLTLGFLVMAVGMGVLGT 337
Cdd:cd17315  186 GLQLLQQLTGINAVMYYAPTIFKSAG--GGTASILASIIVGVVNLLATLVAIRLVDKVGRRPLLLIGFAGMAASLLLLAI 263
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 338 MMHMGIHSPTAQYFAVAMLLMFIIGFAMSAGPLIWVLCSEIQPLKGRDFGITCSTATNWIANMIVGATFLTMLNTLGNAN 417
Cdd:cd17315  264 AFLLPALAKAAGWLALLGILLYIAAFAMGAGPVPWLLLSEIFPLRIRGKGMAIATLVNWIFNFIVGLTFLIMVSTIGLAG 343
                        410       420
                 ....*....|....*....|..
gi 505384730 418 TFWVYAGLNLFFIVLTIWLVPE 439
Cdd:cd17315  344 VFIFFAAVCLLALVFVFFFVPE 365
xylE PRK10077
D-xylose transporter XylE; Provisional
12-450 3.06e-86

D-xylose transporter XylE; Provisional


Pssm-ID: 182225 [Multi-domain]  Cd Length: 479  Bit Score: 272.34  E-value: 3.06e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  12 NKAMTFFVCFLAALAGLLFGLDIGVIAGALP-----FITDEFQISAHTQEW---VVSSMMFGAAVGAVGSGWLSFKLGRK 83
Cdd:PRK10077   6 NSSYIFSITLVATLGGLLFGYDTAVISGTVEslntvFVAPQNLSESAANSLlgfCVASALIGCIIGGALGGYCSNRFGRR 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  84 KSLMIGAILFVAGSLFSAA---------APNVEVLI---ISRVLLGLAVGVASYTAPLYLSEIAPEKIRGSMISMYQLMI 151
Cdd:PRK10077  86 DSLKIAAVLFFISALGSAWpefgftsigPDNTGYVPefvIYRIIGGIGVGLASMLSPMYIAEIAPAHIRGKLVSFNQFAI 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 152 TIGILGAYL--------SDTAFSYSGAWRWMLGVIIIPAILLLIGVFFLPDSPRWFAAKRRFHDAERVLLRLRDTSaEAK 223
Cdd:PRK10077 166 IFGQLVVYFvnyfiarsGDASWLNTDGWRYMFASEAIPALLFLMLLYFVPETPRYLMSRGKQEQAEGILRKIMGNT-LAT 244
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 224 NELEEIRESLKVKQ-SGWALFkenSNFRRAVFLGVLLQIMQQFTGMNVIMYYAPKIFELAGyTNTTEQMWGTVIVGLTNV 302
Cdd:PRK10077 245 QALQEIKHSLDHGRkTGGKLL---MFGVGVIVIGVMLSVFQQFVGINVVLYYAPEIFKTLG-ASTDIALLQTIIVGVINL 320
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 303 LATFIAIGLVDRWGRKPTLTLGFLVMAVGMGVLGTMMHMGIhsptAQYFAVAMLLMFIIGFAMSAGPLIWVLCSEIQPLK 382
Cdd:PRK10077 321 TFTVLAIMTVDKFGRKPLQIIGALGMAIGMFSLGTAFYTQA----PGIVALLSMLFYVAAFAMSWGPVCWVLLSEIFPNA 396
                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 505384730 383 GRDFGITCSTATNWIANMIVGATFLTM------LNTLGNANTFWVYaGLNLFFIVLTIW-LVPETKHVSLEHIER 450
Cdd:PRK10077 397 IRGKALAIAVAAQWIANYFVSWTFPMMdknswlVAHFHNGFSYWIY-GCMGVLAALFMWkFVPETKGKTLEEMEA 470
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
10-399 9.27e-38

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 140.88  E-value: 9.27e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  10 TSNKAMTFFVCFLAALAGLLFGLDIGVIAGALPFITDEFQISAHTQEWVVSSMMFGAAVGAVGSGWLSFKLGRKKSLMIG 89
Cdd:COG2814    2 PATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLG 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  90 AILFVAGSLFSAAAPNVEVLIISRVLLGLAVGVASYTAPLYLSEIAPEKIRGSMISMYQLMITIGILGAYLSDTAFSYSG 169
Cdd:COG2814   82 LLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLF 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 170 AWRWMLGVIIIPAILLLIGV-FFLPDSPRwfAAKRRFHDAERVLLRlrdtsaeakneleeireslkvkqsgwalfkensn 248
Cdd:COG2814  162 GWRWVFLVNAVLALLALLLLlRLLPESRP--AARARLRGSLRELLR---------------------------------- 205
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 249 fRRAVFLGVLLQIMQQFTGMNVIMYYAPKIFELAGYTnTTEQMWGTVIVGLTNVLATFIAIGLVDRWGRKPTLTLGFLVM 328
Cdd:COG2814  206 -RPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLS-ASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLL 283
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 505384730 329 AVGMGVLGtmmhmgihspTAQYFAVAMLLMFIIGFAMS-AGPLIWVLCSEIQPLKGRDFGITCSTATNWIAN 399
Cdd:COG2814  284 ALGLLLLA----------LAGSLWLLLLALFLLGFGFGlLFPLLQALVAELAPPEARGRASGLYNSAFFLGG 345
 
Name Accession Description Interval E-value
SP TIGR00879
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of ...
11-448 6.59e-150

MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of the major facilitator superfamily (pfam00083) [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273317 [Multi-domain]  Cd Length: 481  Bit Score: 435.61  E-value: 6.59e-150
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730   11 SNKAMTFFVCFLAALAGLLFGLDIGVIAGALPFITDEFQI--------SAHTQEWVVSSMMFGAAVGAVGSGWLSFKLGR 82
Cdd:TIGR00879  21 STYWKVALLSLIAAIGGLMFGYDTGVIGGALALPAFEFKFtsansdsySSSLWGLVVSIFLVGGFIGALFAGWLSDRFGR 100
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730   83 KKSLMIGAILFVAGSLFSAAAPN---VEVLIISRVLLGLAVGVASYTAPLYLSEIAPEKIRGSMISMYQLMITIGILGAY 159
Cdd:TIGR00879 101 KKSLLIIALLFVIGAILMGLAAFalsVEMLIVGRVLLGIGVGIASALVPMYLSEIAPKALRGALTSLYQLAITFGILVAY 180
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  160 LSDTA---FSYSGAWRWMLGVIIIPAILLLIGVFFLPDSPRWFAAKRRFHDAERVLLRLRDTSAEAKNELEEIR------ 230
Cdd:TIGR00879 181 GFGSGkvsLNNTLGWRIPLGLQLIPAGLLFLGLFFLPESPRWLVGKGRVEEARKSLARLRGTSGEDKELLDELElidikr 260
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  231 --ESLKVKQSGWALFKENSNFRRAVFLGVLLQIMQQFTGMNVIMYYAPKIFELAGYTNTTeQMWGTVIVGLTNVLATFIA 308
Cdd:TIGR00879 261 siEKRSVQPSWGSLFSSTRRIRRRLFLGVVLQWFQQFTGINAIMYYSPTIFENAGVSTDH-AFLVSIIVGAVNFAFTFVA 339
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  309 IGLVDRWGRKPTLTLGFLVMAVGMGVLGTMMHMGIH--SPTAQYFAVAMLLMFIIGFAMSAGPLIWVLCSEIQPLKGRDF 386
Cdd:TIGR00879 340 IFLVDRFGRRPLLLIGAAGMAICLFVLGILGASFVTgsSKSSGNVAIVFILLFIAFFAMGWGPVPWVIVSEIFPLSLRPK 419
                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 505384730  387 GITCSTATNWIANMIVGATFLTMLNTLGNANTFWVYAGLNLFFIVLTIWLVPETKHVSLEHI 448
Cdd:TIGR00879 420 GISIAVAANWLANFIVGFLFPTMLESIGVGGVFIFFGGLNVLGLIFVYFFLPETKGRTLEEI 481
Sugar_tr pfam00083
Sugar (and other) transporter;
19-452 1.35e-139

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 408.20  E-value: 1.35e-139
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730   19 VCFLAALAGLLFGLDIGVIAGALPFI--TDEFQISAHTQE---------WVVSSMMFGAAVGAVGSGWLSFKLGRKKSLM 87
Cdd:pfam00083   1 VALVAALGGFLFGYDTGVIGAFLTLIdfFKNFGLSKSVSSlaalsvlsgLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730   88 IGAILFVAGSLFSAAAP---NVEVLIISRVLLGLAVGVASYTAPLYLSEIAPEKIRGSMISMYQLMITIGILGAYLSDTA 164
Cdd:pfam00083  81 IANVLFVIGAVLQGAAKgkwSVYQLIVGRVLVGIGVGGASVLAPMYISEIAPKKLRGALGSLYQLAITFGILLAYIFGLG 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  165 FSYSGA---WRWMLGVIIIPAILLLIGVFFLPDSPRWFAAKRRFHDAERVLLRLR---DTSAEAKNELEEIRESLKVKQS 238
Cdd:pfam00083 161 LNKTSNsdgWRIPLGLQLVPALLLIIGLLFLPESPRWLVEKGRLEEAREVLAKLRgvpDVDRELDEIKDSLEAGQEAEKA 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  239 GWALFKENSNFRRAVFLGVLLQIMQQFTGMNVIMYYAPKIFELAGYTNTteqMWGTVIVGLTNVLATFIAIGLVDRWGRK 318
Cdd:pfam00083 241 SWKELFSTKTRRQRLLIGVMLQIFQQLTGINAIFYYSTTIFENLGLSDS---FLVTIIVGVVNFVFTFIAIFLVDRFGRR 317
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  319 PTLTLGFLVMAVGMGVLGTMMHMGIH-SPTAQYFAVAMLLMFIIGFAMSAGPLIWVLCSEIQPLKGRDFGITCSTATNWI 397
Cdd:pfam00083 318 PLLLLGAAGMAICFVILGIVALLGVSkSDWAGIVAIVFIALFIAFFAMGWGPVPWVIVSELFPLSVRSKAMALATAANWL 397
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 505384730  398 ANMIVGATFLTMLNTLGNANTFWVYAGLNLFFIVLTIWLVPETKHVSLEHIERNL 452
Cdd:pfam00083 398 ANFLIGFLFPIITDAIGLGYTFFIFAGLLVLFIIFVFFFVPETKGRTLEEIDELF 452
MFS_GLUT_like cd17315
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ...
22-439 9.32e-133

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340873 [Multi-domain]  Cd Length: 365  Bit Score: 387.70  E-value: 9.32e-133
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  22 LAALAGLLFGLDIGVIAGALPFITDEFQISAHT--QEWVVSSMMFGAAVGAVGSGWLSFKLGRKKSLMIGAILFVAGSLF 99
Cdd:cd17315    1 VAALGGLLFGYDLGVINGALLYIAKDLGFGLSTslQGLVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 100 SAAAPNVEVLIISRVLLGLAVGVASYTAPLYLSEIAPEKIRGSMISMYQLMITIGILGAYLSDTAFSYS--GAWRWMLGV 177
Cdd:cd17315   81 SALAPNVWVLIVGRFLLGLGVGLASVLVPLYISEIAPAKIRGALGTLNQLMITFGILLAYLLGLALSLSppGWWRLMFAL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 178 IIIPAILLLIGVFFLPDSprwfaakrrfhdaervllrlrdtsaeakneleeireslkvkqsgwalfkensnfrRAVFLGV 257
Cdd:cd17315  161 AAVPALLQLLLMFFLPES-------------------------------------------------------RALLVGV 185
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 258 LLQIMQQFTGMNVIMYYAPKIFELAGytNTTEQMWGTVIVGLTNVLATFIAIGLVDRWGRKPTLTLGFLVMAVGMGVLGT 337
Cdd:cd17315  186 GLQLLQQLTGINAVMYYAPTIFKSAG--GGTASILASIIVGVVNLLATLVAIRLVDKVGRRPLLLIGFAGMAASLLLLAI 263
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 338 MMHMGIHSPTAQYFAVAMLLMFIIGFAMSAGPLIWVLCSEIQPLKGRDFGITCSTATNWIANMIVGATFLTMLNTLGNAN 417
Cdd:cd17315  264 AFLLPALAKAAGWLALLGILLYIAAFAMGAGPVPWLLLSEIFPLRIRGKGMAIATLVNWIFNFIVGLTFLIMVSTIGLAG 343
                        410       420
                 ....*....|....*....|..
gi 505384730 418 TFWVYAGLNLFFIVLTIWLVPE 439
Cdd:cd17315  344 VFIFFAAVCLLALVFVFFFVPE 365
MFS_XylE_like cd17359
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ...
18-439 1.12e-117

D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340917 [Multi-domain]  Cd Length: 383  Bit Score: 349.94  E-value: 1.12e-117
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  18 FVCFLAALAGLLFGLDIGVIAGALPFITDEFQISAHTQEWVVSSMMFGAAVGAVGSGWLSFKLGRKKSLMIGAILFVAGS 97
Cdd:cd17359    1 LISLVAALGGLLFGYDTGVINGALPFLQTDFNLTPFLEGLVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISA 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  98 LFSAAAPNVEVLIISRVLLGLAVGVASYTAPLYLSEIAPEKIRGSMISMYQLMITIGILGAYLSDTAFSYSG-------- 169
Cdd:cd17359   81 LGSAFSPNFTIFIIARIIGGLAVGGASALVPMYIAEVAPAEIRGRLVSLNQLMIVFGQLLAYIVNYLIANAGgadwlgae 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 170 AWRWMLGVIIIPAILLLIGVFFLPDSPRWFAAKRrfhdaervllrlrdtsaeakneleeireslkvkqsgwalfkensnf 249
Cdd:cd17359  161 GWRWMLGLEAIPAILFLLGMLFIPESPRWLVSKG---------------------------------------------- 194
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 250 RRAVFLGVLLQIMQQFTGMNVIMYYAPKIFELAGYTnTTEQMWGTVIVGLTNVLATFIAIGLVDRWGRKPTLTLGFLVMA 329
Cdd:cd17359  195 KPILIIGIGLAIFQQFVGINVIFYYGPEIFQNAGFS-ENAALLQTIGIGVVNVIFTIIAILLVDKVGRKPLLLIGSIGMA 273
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 330 VGMGVLGTMMHMGIHSPTAQYFAVAMLLMFIIGFAMSAGPLIWVLCSEIQPLKGRDFGITCSTATNWIANMIVGATFLTM 409
Cdd:cd17359  274 ISLLLIGTAFYFAPGSQASGIVALVLILLFVAFFAMSWGPVTWVLLSEIFPNRIRGLAMGIAVFFLWIANFLVSLTFPIL 353
                        410       420       430
                 ....*....|....*....|....*....|
gi 505384730 410 LNTLGNANTFWVYAGLNLFFIVLTIWLVPE 439
Cdd:cd17359  354 LAAFGLAFTFLIFAVICVLAFLFVWKFVPE 383
MFS_HMIT_like cd17360
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ...
23-439 1.28e-101

H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340918 [Multi-domain]  Cd Length: 362  Bit Score: 308.04  E-value: 1.28e-101
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  23 AALAGLLFGLDIGVIAGALPFITDEFQISAHT---QEWVVSSMMFGAAVGAVGSGWLSFKLGRKKSLMIGAILFVAGSLF 99
Cdd:cd17360    2 AGIGGFLFGYDTGVISGALLYIKDDLGEVVLStgwQELIVSSTVAGAAVGAAIGGWLNDRFGRRPCILLADALFTIGAIV 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 100 SAAAPNVEVLIISRVLLGLAVGVASYTAPLYLSEIAPEKIRGSMISMYQLMITIGILGAYLSDTAFSY-SGAWRWMLGVI 178
Cdd:cd17360   82 MAAAPNKEVLIVGRVLVGLGVGIASMTVPLYIAEAAPPRIRGRLVTINVLFITGGQFVAYVINGAFSYlPGGWRWMLGLA 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 179 IIPAILLLIGVFFLPDSPRWfaakrrfhdaervllrlrdtsaeakneleeireslkvkqsgwalfKENsnfRRAVFLGVL 258
Cdd:cd17360  162 AVPAVLQFIGLLFLPESPRW---------------------------------------------PST---RRALIVGCG 193
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 259 LQIMQQFTGMNVIMYYAPKIFELAGYTNTTEQMWGTVIVGLTNVLATFIAIGLVDRWGRKPTLTLGFLVMAVGMGVLgtm 338
Cdd:cd17360  194 LQAFQQFSGINTVMYYSATILQMAGFKDNQNAIWLSLIVAGTNFIFTIVGMYLIDKFGRRKLLLISLFGVIVALVVL--- 270
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 339 mhmgihsptAQYFAVAMLLMFIIGFAMSAGPLIWVLCSEIQPLKGRDFGITCSTATNWIANMIVGATFLTMLNTLGNANT 418
Cdd:cd17360  271 ---------AVWLALVGLILYLAFFAPGMGPVPWTVNSEIYPLWARGTGGGCAAAVNWVFNLLVSQTFLTLTQAIGPYGT 341
                        410       420
                 ....*....|....*....|.
gi 505384730 419 FWVYAGLNLFFIVLTIWLVPE 439
Cdd:cd17360  342 FLLFAGLAVLGLIFIYFCVPE 362
MFS_GLUT6_8_Class3_like cd17358
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ...
17-447 1.82e-96

Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340916 [Multi-domain]  Cd Length: 436  Bit Score: 297.18  E-value: 1.82e-96
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  17 FFVCFLAALAGLLFGLDIGVIAGALPFITDE----FQISAHTQEWVVSSMMFGAAVGAVGSGWLSFKLGRKKSLMIGAIL 92
Cdd:cd17358    1 LLATFVANLGSFSFGIAVGWSSPALPSLMSDnslsLPLTVAQFSWFGSLLTLGALIGALLSGKLADRIGRKRTLLISAIP 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  93 FVAGSLFSAAAPNVEVLIISRVLLGLAVGVASYTAPLYLSEIAPEKIRGSMISMYQLMITIGILGAYLSDTAFSysgaWR 172
Cdd:cd17358   81 CILGWLLIAFAKDVWMLYLGRFLAGFGGGAASVVVPVYIAEIAPKNVRGALGSLNQLLVNIGILLGYVLGSFLP----WR 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 173 WMLGVIIIPAILLLIGVFFLPDSPRWFAAKRRFHDAERVLLRLRDTSAEAKNELEEIRESLK-----VKQSGWALFKENS 247
Cdd:cd17358  157 TLALIGAIPPVVFLILLFFIPESPRWLAKKGREEEAEKSLQFLRGKDADISKEAAEIQEELAelekeAKESSFSDLFQRK 236
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 248 NfRRAVFLGVLLQIMQQFTGMNVIMYYAPKIFELAGytNTTEQMWGTVIVGLTNVLATFIAIGLVDRWGRKPTLTLGFLV 327
Cdd:cd17358  237 Y-LKPLVIGLGLMLFQQLSGINAVIFYASSIFDEAG--SGLDPNTATIIIGVVQVVGTLVATLLVDRLGRRPLLLVSAIG 313
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 328 MAVGMGVLGTMMHMGIHSPTAQ---YFAVAMLLMFIIGFAMSAGPLIWVLCSEIQPLKGRDFGITCSTATNWIANMIVGA 404
Cdd:cd17358  314 MGIGLLALGLYFYLQEHGALLSsvsWLPLVGLVIYIISFSIGLGPLPWVIMSEIFPAKIKGLAGSLVTLVNWLFAFIVTK 393
                        410       420       430       440
                 ....*....|....*....|....*....|....*....|...
gi 505384730 405 TFLTMLNTLGNANTFWVYAGLNLFFIVLTIWLVPETKHVSLEH 447
Cdd:cd17358  394 TFPFLTLAWGASGTFWIFAGICGLALVFVLLFVPETKGKSLEE 436
xylE PRK10077
D-xylose transporter XylE; Provisional
12-450 3.06e-86

D-xylose transporter XylE; Provisional


Pssm-ID: 182225 [Multi-domain]  Cd Length: 479  Bit Score: 272.34  E-value: 3.06e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  12 NKAMTFFVCFLAALAGLLFGLDIGVIAGALP-----FITDEFQISAHTQEW---VVSSMMFGAAVGAVGSGWLSFKLGRK 83
Cdd:PRK10077   6 NSSYIFSITLVATLGGLLFGYDTAVISGTVEslntvFVAPQNLSESAANSLlgfCVASALIGCIIGGALGGYCSNRFGRR 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  84 KSLMIGAILFVAGSLFSAA---------APNVEVLI---ISRVLLGLAVGVASYTAPLYLSEIAPEKIRGSMISMYQLMI 151
Cdd:PRK10077  86 DSLKIAAVLFFISALGSAWpefgftsigPDNTGYVPefvIYRIIGGIGVGLASMLSPMYIAEIAPAHIRGKLVSFNQFAI 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 152 TIGILGAYL--------SDTAFSYSGAWRWMLGVIIIPAILLLIGVFFLPDSPRWFAAKRRFHDAERVLLRLRDTSaEAK 223
Cdd:PRK10077 166 IFGQLVVYFvnyfiarsGDASWLNTDGWRYMFASEAIPALLFLMLLYFVPETPRYLMSRGKQEQAEGILRKIMGNT-LAT 244
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 224 NELEEIRESLKVKQ-SGWALFkenSNFRRAVFLGVLLQIMQQFTGMNVIMYYAPKIFELAGyTNTTEQMWGTVIVGLTNV 302
Cdd:PRK10077 245 QALQEIKHSLDHGRkTGGKLL---MFGVGVIVIGVMLSVFQQFVGINVVLYYAPEIFKTLG-ASTDIALLQTIIVGVINL 320
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 303 LATFIAIGLVDRWGRKPTLTLGFLVMAVGMGVLGTMMHMGIhsptAQYFAVAMLLMFIIGFAMSAGPLIWVLCSEIQPLK 382
Cdd:PRK10077 321 TFTVLAIMTVDKFGRKPLQIIGALGMAIGMFSLGTAFYTQA----PGIVALLSMLFYVAAFAMSWGPVCWVLLSEIFPNA 396
                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 505384730 383 GRDFGITCSTATNWIANMIVGATFLTM------LNTLGNANTFWVYaGLNLFFIVLTIW-LVPETKHVSLEHIER 450
Cdd:PRK10077 397 IRGKALAIAVAAQWIANYFVSWTFPMMdknswlVAHFHNGFSYWIY-GCMGVLAALFMWkFVPETKGKTLEEMEA 470
MFS_GLUT10_12_Class3_like cd17362
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ...
23-448 2.55e-85

Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340920 [Multi-domain]  Cd Length: 389  Bit Score: 266.91  E-value: 2.55e-85
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  23 AALAGLLFGLDIGVIAGALPFI-------TDEFQISAHTQEWVVSSMMFGAAVGAVGSGWLSFKLGRKKSLMIGAILFVA 95
Cdd:cd17362    2 PALGGLLFGYDIGATSGALLSItspalsgTDWYNLSSLQSGLVVSGSLLGALLGSLVAGALIDRLGRRKELILAALLYLV 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  96 GSLFSAAAPNVEVLIISRVLLGLAVGVASYTAPLYLSEIAPEKIRGSMISMYQLMITIGILGAYLSDTAF-SYSGAWRWM 174
Cdd:cd17362   82 GSLVTGLAPSYPVLLVGRLIYGVGIGLAMHAAPVYIAETSPSHIRGLLVSLKELFIVLGILLGYVSGYAFaDVVGGWRYM 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 175 LGVIIIPAILLLIGVFFLPDSPRWfaakrrfhdaervllrlrdtsaeakneleeireslkvkqsgwalfkeNSNFRRAVF 254
Cdd:cd17362  162 YGLAAPPALLLGIGMWFLPPSPRW-----------------------------------------------QGNYRKPLI 194
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 255 LGVLLQIMQQFTGMNVIMYYAPKIFELAGYTNTTEQMWGTVIVGLTNVLATFIAIGLVDRWGRKPTLTLGFLVMAVGMGV 334
Cdd:cd17362  195 IGLGLVLFQQITGQPSVLYYAATIFKSAGFSAASDATLVSVGLGVFKLLMTIVAVLLVDKLGRRPLLLGGVSGMVVSLFL 274
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 335 LGTMMHMGIHSPTAQ-YFAVAMLLMFIIGFAMSAGPLIWVLCSEIQPLKGRDFGITCSTATNWIANMIVGATFLTMLNTL 413
Cdd:cd17362  275 LAAYNLFVQMGPAGLaWLSLVALLLYVGAYQISFGPISWLMVSEIFPLRVRGRAIALAVLVNFGSNALVSLAFLPLQELI 354
                        410       420       430
                 ....*....|....*....|....*....|....*
gi 505384730 414 GNANTFWVYAGLNLFFIVLTIWLVPETKHVSLEHI 448
Cdd:cd17362  355 GLPGTFLGFGVIGVLALLFIYFTVPETKGLSLEEI 389
MFS_GLUT8_Class3 cd17433
Glucose transporter type 8, a Class 3 GLUT, of the Major Facilitator Superfamily of ...
17-446 9.56e-73

Glucose transporter type 8, a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 8 (GLUT8) is also called Solute carrier family 2, facilitated glucose transporter member 8 (SLC2A8) or glucose transporter type X1 (GLUTX1). It is classified as a Class 3 GLUT protein and is an insulin-regulated facilitative glucose transporter predominantly expressed in testis and brain. It can also transport fructose and galactose. SLC2A8 knockout mice were viable, developed normally, and display only a very mild phenotype, including mild alterations in the brain (increased proliferation of hippocampal neurons), heart (impaired transmission of electrical wave through the atrium), and sperm cells (reduced number of motile sperm cells). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340991 [Multi-domain]  Cd Length: 416  Bit Score: 235.54  E-value: 9.56e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  17 FFVCFLAALAGLLFGLDIGVIAGALPFITD----EFQISAHTQEWVVSSMMFGAAVGAVGSGWLSFKLGRKKSLMIGAIL 92
Cdd:cd17433    1 FLATFAAVLGPLSFGFVLGYSSPAIPSLQRiadpALRLDDAAASWFGSVVTLGAAAGGVLGGWIVDRAGRKLSLMLCSVP 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  93 FVAGSLFSAAAPNVEVLIISRVLLGLAVGVASYTAPLYLSEIAPEKIRGSMISMYQLMITIGILGAYLSDTAFSysgaWR 172
Cdd:cd17433   81 FIAGFTVITAAQNVWMLYVGRLLTGLASGVTSLVVPVYISEIAHPRVRGTLGSCVQLMVVIGIMGAYLAGLVLD----WR 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 173 WMLGVIIIPAILLLIGVFFLPDSPRWFAAKRRFHDAERVLLRLRDTSAEAKNELEEIRESLKVKQSGWALFK-ENSNFRR 251
Cdd:cd17433  157 WLAVLGSIPPTLMLLLMCFMPETPRFLLTQHRRQEAMAALRFLRGPDQGWEWECIGIEQSFHLEEQSFSLALlKQPGIYK 236
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 252 AVFLGVLLQIMQQFTGMNVIMYYAPKIFELAGYTNTTeqmWGTVIVGLTNVLATFIAIGLVDRWGRKPTLTLGFLVMAVG 331
Cdd:cd17433  237 PLIIGVSLMAFQQLTGINAVMFYAETIFEEAKFKDSS---VASVIVAAIQVLFTAVAALIMDRAGRKVLLVLSGVVMVFS 313
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 332 MGVLGtmmhmgihsptaqYFAVAMLLMFIIGFAMSAGPLIWVLCSEIQPLKGRDFGITCSTATNWIANMIVGATFLTMLN 411
Cdd:cd17433  314 TAAFG-------------WLAVGSMGFFIAGFAVGWGPIPWLVMSEIFPLHVRGVASGICVLTNWLMAFLVTKEFSSLME 380
                        410       420       430
                 ....*....|....*....|....*....|....*
gi 505384730 412 TLGNANTFWVYAGLNLFFIVLTIWLVPETKHVSLE 446
Cdd:cd17433  381 VLSSYGTFWLFSAFCAFSVLFTLFCVPETKGKTLE 415
MFS_HXT cd17356
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ...
18-450 2.87e-70

Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340914 [Multi-domain]  Cd Length: 403  Bit Score: 228.67  E-value: 2.87e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  18 FVCFLAALAGLLFGLDIGVIAGAL---------PFITDEFQISAHTQEWVVSSMMFGAAVGAVGSGWLSFKLGRKKSLMI 88
Cdd:cd17356    1 LLCAFVSLGGFLFGYDTGSISGILnmksfqkyfADNTGTYYPSSSRQGLIVSIVNLGSFFGALISSFLSDRIGRKKSIQI 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  89 GAILFVAGSLFS-AAAPNVEVLIISRVLLGLAVGVASYTAPLYLSEIAPEKIRGSMISMYQLMITIGILGAYLSDTAFSY 167
Cdd:cd17356   81 GCVIYIIGAIIQvAAIGKWYQLIVGRIIAGLGVGFASVLVPVYQSEVAPKHIRGTLVSLYQLAITIGILVAYCINYGTHK 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 168 ---SGAWRWMLGVIIIPAILLLIGVFFLPDSPRWfaakrrfhdaervLLRLrdtsaeakneleeireslkvkqsgwalfk 244
Cdd:cd17356  161 ldgSAQWRIPLGLQIVWGLLLLIGMFFLPESPRW-------------LYRT----------------------------- 198
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 245 ensnfrravFLGVLLQIMQQFTGMNVIMYYAPKIFELAGYTNtTEQMWGTVIVGLTNVLATFIAIGLVDRWGRKPTLTLG 324
Cdd:cd17356  199 ---------ILGIMLQLFQQLTGINYFFYYGTTIFQSTGLTG-SSPLLTSIILYIVNFVSTIPGLFFVDKFGRRTCLLIG 268
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 325 FLVM--------AVGMGVLGTMMHMGIHSPTAQYFAVAMLLMFIIGFAMSAGPLIWVLCSEIQPLKGRDFGITCSTATNW 396
Cdd:cd17356  269 AAGMsiclfiyaAVGVRYLIPNPQSGTSNKSAGNGMIVFICLFIFSFATTWGPIAWVYVAEVFPLRVRSKGMALATAFNW 348
                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....
gi 505384730 397 IANMIVGATFLTMLNTLGnANTFWVYAGLNLFFIVLTIWLVPETKHVSLEHIER 450
Cdd:cd17356  349 LWNFLISFFTPFIIGSIG-FKYYYIFAGCNLLAFIVVFFFVPETKGLTLEEIDE 401
MFS_STP cd17361
Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; ...
22-439 6.54e-70

Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; The plant Sugar transport protein (STP) subfamily includes STP1-STP14; they are also called hexose transporters. They mediate the active uptake of hexoses such as glucose, 3-O-methylglucose, fructose, xylose, mannose, galactose, fucose, 2-deoxyglucose and arabinose, by sugar/hydrogen symport. Several STP family transporters are expressed in a tissue-specific manner, or at specific developmental stages. STP1 is the member with the highest expression level of all members and high expression is detected in photosynthetic tissues, such as leaves and stems, while roots, siliques, and flowers show lower expression levels. It plays a major role in the uptake and response of Arabidopsis seeds and seedlings to sugars. The STP subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340919 [Multi-domain]  Cd Length: 390  Bit Score: 227.13  E-value: 6.54e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  22 LAALAGLLFGLDIGVIAGAL---PFITDEF------QISAHTQEW----------VVSSMMFGAAVGAVGSGWLSFKLGR 82
Cdd:cd17361    1 VAALGGLIFGYDIGISGGVTsmdPFLEKFFpsvyekKKGASENNYckyddqllqlFTSSLYLAGLVASLLASYVTRKWGR 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  83 KKSLMIGAILFVAGSLFSAAAPNVEVLIISRVLLGLAVGVASYTAPLYLSEIAPEKIRGSMISMYQLMITIGILGAYLSD 162
Cdd:cd17361   81 KPSMLIGGVLFLVGAALNAAAQNIAMLIVGRILLGFGVGFGNQAVPLYLSEMAPAKLRGALNIGFQLAITIGILIANLIN 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 163 TAFSYSGA--WRWMLGVIIIPAILLLIGVFFLPDSPrwfaakrrfhdaervllrlrdTSAEakneleeireslkvkqsgw 240
Cdd:cd17361  161 YGTSKIKPngWRLSLGLAAVPALILLLGSLFLPETP---------------------NSPQ------------------- 200
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 241 alfkensnfrraVFLGVLLQIMQQFTGMNVIMYYAPKIFELAGYTNTTEQMwGTVIVGLTNVLATFIAIGLVDRWGRKPT 320
Cdd:cd17361  201 ------------LVIAILIPFFQQLTGINVIMFYAPVLFQTLGFGSDASLI-SAVITGAVNVVSTLVSIYLVDRFGRRFL 267
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 321 LTLGFLVMAVGMGVLGTMMHM----GIHSPTAQ-YFAVAMLLMFIIGFAMSAGPLIWVLCSEIQPLKGRDFGITCSTATN 395
Cdd:cd17361  268 LLEGGVQMLASQVAIGILLAVkfgdGGELPKAYaIAVVVLICLYVAAFAWSWGPLGWLVPSEIFPLETRSAGQSLTVAVN 347
                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....
gi 505384730 396 WIANMIVGATFLTMLNTLgNANTFWVYAGLNLFFIVLTIWLVPE 439
Cdd:cd17361  348 FLFTFVIAQAFLSMLCAM-KFGIFLFFAGWVVVMSLFVYFLLPE 390
MFS_GLUT_Class1_2_like cd17357
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ...
58-441 6.01e-68

Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340915 [Multi-domain]  Cd Length: 447  Bit Score: 223.68  E-value: 6.01e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  58 VVSSMMFGAAVGAVGSGWLSFKLGRKKSLMIGAILFVAGSL---FSAAAPNVEVLIISRVLLGLAVGVASYTAPLYLSEI 134
Cdd:cd17357   54 IVSIFFIGGAIGSFISAFLANRFGRKNGLLISNALLVVSSLlmfLSKSAKSPELLIFGRFLVGIACGLSTGFVPMYLQEI 133
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 135 APEKIRGSMISMYQLMITIGIL-GAYLS-DTAFSYSGAWRWMLGVIIIPAILLLIGVFFLPDSPRW-FAAKRRFHDAERV 211
Cdd:cd17357  134 SPSELRGALGSLTQIGVTLGILlGQVFGlPSVLGTETLWPYLLFFPGIPALLQLAALPFFPESPKFlLISKGDEEEAEKS 213
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 212 LLRLRDTSAEAKNELEEIR-ESLKVKQSG----WALFKENSNfRRAVFLGVLLQIMQQFTGMNVIMYYAPKIFELAGYTn 286
Cdd:cd17357  214 LKFLRGIEDDVDQELEEIKkESEQMGDQKqvslMQLLRDPSL-RLPLLLVLVVSASQQFSGINAIFFYSTFIFENAGFS- 291
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 287 TTEQMWGTVIVGLTNVLATFIAIGLVDRWGRKPTLTLGFLVMAVGMGVLGTMMHMGIHSPTAQYFAVAMLLMFIIGFAMS 366
Cdd:cd17357  292 PQLAEWANLGIGIVNVLSTIVGPFLIEKVGRRPLLLISLSVCAVALLLMSVFLFLSEQNSWMSYGCIVAIFLFIFFFAIG 371
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 505384730 367 AGPLIWVLCSEIQPLKGRDFGITCSTATNWIANMIVGATFLTMLNTLGNAnTFWVYAGLNLFFIVLTIWLVPETK 441
Cdd:cd17357  372 LGPIPWFIGAELFPQAPRSAAQSLGSSVNWTSNFIVGMAFPPLQSIGGGF-VFIIFAIPCALFLLYLYRYLPETK 445
MFS_PLT cd17437
Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The ...
22-448 1.05e-64

Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The plant Polyol transporter (PLT) subfamily includes PLT1-6 from Arabidopsis thaliana and similar transporters. The best characterized member of the group is Polyol transporter 5, also called Sugar-proton symporter PLT5, which mediates the H+-symport of numerous substrates including linear polyols (such as sorbitol, xylitol, erythritol or glycerol), cyclic polyol myo-inositol, and different hexoses, pentoses (including ribose), tetroses, and sugar alcohols. It functions to transport a wide range of substrates into specific sink tissues in the plant. The PLT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340995 [Multi-domain]  Cd Length: 387  Bit Score: 213.42  E-value: 1.05e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  22 LAALAGLLFGLDIGVIAGALPFITDEFQISAHTQEWVVSSMMFGAAVGAVGSGWLSFKLGRKKSLMIGAILFVAGSLFSA 101
Cdd:cd17437    1 LASLNSILLGYDIGVMSGAVIFIKEDLKISDVQEEVLIGSLNIISLVGSLAAGRTSDWIGRRYTIALAALIFFVGALLMG 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 102 AAPNVEVLIISRVLLGLAVGVASYTAPLYLSEIAPEKIRGSMISMYQLMITIGILGAYLSDTAFSYSGA---WRWMLGVI 178
Cdd:cd17437   81 VAPNYPVLMVGRFVAGIGVGFALMIAPVYTAEVAPASSRGFLTSFPEIFINIGILLGYVSNYAFSGLPLhvgWRLMLGVG 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 179 IIPAILLLIGVFFLPDSPRWFAAkrrfhdaervllrlrdtsaeakneleeireslkvkqsgwalfkensnFRRAVFLGVL 258
Cdd:cd17437  161 AVPSLFLAIGVLAMPESPRWTPA-----------------------------------------------VRRMLIAALG 193
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 259 LQIMQQFTGMNVIMYYAPKIFELAGYTNTTEQMWGTVIVGLTNVLATFIAIGLVDRWGRKPTLTLGFLVMAVGMGVLGTM 338
Cdd:cd17437  194 IHFFQQASGIDAVVLYSPRIFKKAGIKSKDKLLLATVAVGVTKTLFILVATFLLDKVGRRPLLLTSTGGMTLSLTALATS 273
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 339 MHM----GIHSPTAQYFAVAMLLMFIIGFAMSAGPLIWVLCSEIQPLKGRDFGITCSTATNWIANMIVGATFLTMLNTLG 414
Cdd:cd17437  274 LTFidrnGGGLTWALVLAITAVCSFVAFFSIGAGPITWVYSSEIFPLRLRAQGASLGVVVNRLMSGTVSMTFLSMSKAIT 353
                        410       420       430
                 ....*....|....*....|....*....|....
gi 505384730 415 NANTFWVYAGLNLFFIVLTIWLVPETKHVSLEHI 448
Cdd:cd17437  354 TGGTFFLFAGVAAAAWVFFYFFLPETKGKSLEEI 387
MFS_GLUT_Class1 cd17431
Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ...
18-441 1.19e-60

Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-4 are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT1, also called solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1), displays broad substrate specificity and can transport a wide range of pentoses and hexoses including glucose, galactose, mannose, and glucosamine. It is found in the brain, erythrocytes, and in many fetal tissues. GLUT2 (or SLC2A2) is found in the liver, islet of Langerhans, intestine, and kidney, and is the isoform that likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by beta cells. GLUT3 (or SLC2A3) is found in the brain and can mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and dehydroascorbate. GLUT4 (or SLC2A4) is an insulin-regulated facilitative glucose transporter found in adipose tissues, and in skeletal and cardiac muscle. GLUT14 (or SLC2A14) is an orphan transporter expressed mainly in the testis. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340989 [Multi-domain]  Cd Length: 445  Bit Score: 204.49  E-value: 1.19e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  18 FVCFLAALAGLLFGLDIGVIAGALPFITDEFQ----------ISAH--TQEWVVSSMMF--GAAVGAVGSGWLSFKLGRK 83
Cdd:cd17431    1 FAVFVAVLGSLQFGYNTGVINAPQKVIEEFYNktlgdrygepISPEtlTTLWSLSVAIFsvGGMIGSFSVGLFVNRFGRR 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  84 KSLMIGAILFVAGSL---FSAAAPNVEVLIISRVLLGLAVGVASYTAPLYLSEIAPEKIRGSMISMYQLMITIGILGAYL 160
Cdd:cd17431   81 NSMLYNNLLAFAGAAlmgLSKLAKSYEMLILGRFIIGLYCGLTTGLVPMYIGEISPTALRGALGTLHQLGIVVGILISQI 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 161 --SDTAFSYSGAWRWMLGVIIIPAILLLIGVFFLPDSPRWFAAKR-RFHDAERVLLRLR---DTSAEAKNELEEIRESLK 234
Cdd:cd17431  161 fgLEFILGTEELWPLLLGFTIVPAILQLALLPFCPESPRYLLINRnEEEEAKSVLKKLRgttDVSEDIQEMKEESRQMMR 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 235 VKQSGWALFKENSNFRRAVFLGVLLQIMQQFTGMNVIMYYAPKIFELAGytnTTEQMWGTVIVGLTNVLATFIAIGLVDR 314
Cdd:cd17431  241 EKKVTILELFRSSSYRQPIIIAIVLQLSQQLSGINAVFYYSTSIFEKAG---VQQPVYATIGAGVVNTIFTVVSLFLVER 317
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 315 WGRKpTLtlgFLVMAVGMGVLGTMMHMGI----HSPTAQYFAVAMLLMFIIGFAMSAGPLIWVLCSEIQPLKGRDFGITC 390
Cdd:cd17431  318 AGRR-TL---HLIGLGGMAICAILMTIALllleGYPWMSYVSIVAIFGFVAFFEIGPGPIPWFIVAELFSQGPRPAAMAV 393
                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|.
gi 505384730 391 STATNWIANMIVGATFLTMLNTLGNAnTFWVYAGLNLFFIVLTIWLVPETK 441
Cdd:cd17431  394 AGFSNWTSNFIVGMCFQYIANLCGPY-VFIIFTVFLLTFFIFTYFKVPETK 443
MFS_GLUT12_Class3 cd17435
Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of ...
23-448 1.19e-60

Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 12 (GLUT12) is also called Solute carrier family 2, facilitated glucose transporter member 12 (SLC2A12). It is a facilitative glucose transporter, classified as a Class 3 GLUT, and is expressed in the heart, skeletal muscle, prostate, and small intestine, and is highly upregulated in breast ductal cell carcinoma. It plays a role as a secondary insulin-sensitive glucose transporter in insulin-dependent tissues. The GLUT12 subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340993 [Multi-domain]  Cd Length: 376  Bit Score: 202.72  E-value: 1.19e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  23 AALAGLLFGLDIGVIAGALPFITDEFQISAHTQEWVVSSMMFGAAVGAVGSGWLSFKLGRKKSLMIGAILFVAGSLFSAA 102
Cdd:cd17435    6 AAVSGLLVGYELGIISGALLQLRTLLALSCHEQEMVVSSLLIGALLASLTGGVLIDRYGRRTAIILTSCLLVLGSLLLVC 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 103 APNVEVLIISRVLLGLAVGVASYTAPLYLSEIAPEKIRGSMISMYQLMITIGILGAYLSDTAF-SYSGAWRWMLGVIIIP 181
Cdd:cd17435   86 SVSYTVLIVGRIAIGVSISLSSIATCVYIAEIAPQHRRGLLVSLNELMIVIGILLAYISNYAFaNVSNGWKYMFGLVIPL 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 182 AILLLIGVFFLPDSPRWFAAKrrfhdaervllrlrdtsaeakneleeireslkvkqsgwalfkenSNFRRAVFLGVLLQI 261
Cdd:cd17435  166 AALQAIAMYFLPPSPRFLVMK--------------------------------------------DNMRARLLIGLTLVF 201
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 262 MQQFTGMNVIMYYAPKIFELAGYTNTTEQMWGTVIVGLTNVLATFIAIGLVDRWGRKPTLTLGFLVMAVGMGVLGTmmhm 341
Cdd:cd17435  202 FVQITGQPNILFYASTVLKSVGFQSNEAASLASTGVGVVKVVSTIPAIFLVDKVGSKTFLCIGSSVMAVSLVTMGL---- 277
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 342 gihsptaqYFAVAMLLMFIIGFAMSAGPLIWVLCSEIQP--LKGRDFGITcsTATNWIANMIVGATFLTMLNTLGNANTF 419
Cdd:cd17435  278 --------WLSLASLLVYVAAFSIGLGPMPWLVLSEIFPggIRGRAMALT--SSMNWGINLLISLTFLTVTELIGLPWVC 347
                        410       420
                 ....*....|....*....|....*....
gi 505384730 420 WVYAGLNLFFIVLTIWLVPETKHVSLEHI 448
Cdd:cd17435  348 FIYTAMSLASLVFVIMFVPETKGCSLEQI 376
MFS_GLUT10_Class3 cd17436
Glucose transporter type 10 (GLUT10), a Class 3 GLUT, of the Major Facilitator Superfamily of ...
25-448 8.90e-52

Glucose transporter type 10 (GLUT10), a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 10 (GLUT10) is also called Solute carrier family 2, facilitated glucose transporter member 10 (SLC2A10). It is classified as a Class 3 GLUT and is a facilitative glucose transporter that exhibits a wide tissue distribution. It is expressed in pancreas, placenta, heart, lung, liver, brain, fat, muscle, and kidney. GLUT10 facilitates the transport of dehydroascorbic acid (DHA), the oxidized form of vitamin C, into mitochondria, and also increases cellular uptake of DHA, which in turn protects cells against oxidative stress. Loss-of-function mutations in SLC2A10 cause arterial tortuosity syndrome (ATS), an autosomal recessive connective tissue disorder characterized by twisting and lengthening of the major arteries, hypermobility of the joints, and laxity of skin. The GLUT10 subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340994 [Multi-domain]  Cd Length: 376  Bit Score: 179.23  E-value: 8.90e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  25 LAGLLFGLDIGVIAGALPFITDEFQISAHTQEWVVSSMMFGAAVGAVGSGWLSFKLGRKKSLMIGAILFVAGSLFSAAAP 104
Cdd:cd17436    8 LGGLTFGYELGIISGALLQLQTDFSLSCFEQEALVSALLIGALLASLIGGFLIDRHGRRTSILGSNLVLLAGSLILTLAG 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 105 NVEVLIISRVLLGLAVGVASYTAPLYLSEIAPEKIRGSMISMYQLMITIGILGAYLSDTAFS-YSGAWRWMLGVIIIPAI 183
Cdd:cd17436   88 SFFWLVIGRAVVGFAISVSSMACCIYVSEMVTPHQRGLLVSLYEAGITVGILISYALNYFFSnVLTGWRYMFGLAIIPAA 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 184 LLLIGVFFLPDSPRWFAAKrrfhdaervllrlrdtsaeakneleeireslkvkqsgwalfkenSNFRRAVFLGVLLQIMQ 263
Cdd:cd17436  168 IQFASILLLPKKPEVLNIK--------------------------------------------DNMRRRTLVGLGLVLFQ 203
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 264 QFTGMNVIMYYAPKIFELAGYTNTTEQMWGTVIVGLTNVLATFIAIGLVDRWGRKPTLTLGFLVMAVGMGVLGTmmhmgi 343
Cdd:cd17436  204 QFTGQPNVLCYASTIFRSVGFQSNSSAVLASVGLGVVKVIATLLAMLFADRAGRRSLLIAGCSVMAVSVSGIGL------ 277
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 344 hsptaqYFAVAMLLMFIIGFAMSAGPLIWVLCSEIQPLKGRDFGITCSTATNWIANMIVGATFLTMLNTLGNANTFWVYA 423
Cdd:cd17436  278 ------WITLLCLMAFVSAFSIGFGPMTWLVLSEIYPADIRGRAFSFCNSFNWAANLLITLSFLDLIDVIGLSWTFLLYG 351
                        410       420
                 ....*....|....*....|....*
gi 505384730 424 GLNLFFIVLTIWLVPETKHVSLEHI 448
Cdd:cd17436  352 VVGVAGVVFIYLFVPETKGQSLEEI 376
MFS_GLUT_Class2 cd17432
Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ...
21-441 1.13e-49

Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT5, also called Solute carrier family 2, facilitated glucose transporter member 5 (SLC2A5), is a well-established fructose transporter found in the small intestine. GLUT7 (or SLC2A7) is a high-affinity glucose and fructose transporter expressed in the small intestine and colon. GLUT9 (or SLC2A9) transports urate and fructose, and is most strongly expressed in the basolateral membranes of proximal renal tubular cells, liver and placenta. It may play a role in urate reabsorption by proximal tubules. GLUT11 (or SLC2A11) is a facilitative glucose transporter expressed in heart and skeletal muscle. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340990 [Multi-domain]  Cd Length: 452  Bit Score: 175.50  E-value: 1.13e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  21 FLAALAG-LLFGLDIGVIAGALPFITDEF----------QISAHTQE--W--VVSSMMFGAAVGAVGSGWLSFKLGRKKS 85
Cdd:cd17432    3 LAAAFGSsFQYGYNLSVVNSPTPYIQNFYnetwterygtPLEESTLTllWslTVSIFPLGGLFGSLLVGPLVIRLGRKGT 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  86 LMIGAILFVAGSL---FSAAAPNVEVLIISRVLLGLAVGVASYTAPLYLSEIAPEKIRGSMISMYQLMITIGILGAY--- 159
Cdd:cd17432   83 LLLNNIFAIVAAIlmgLSKIAKSFEMIIVGRFLVGINAGISLNVVPMYLGESAPKNLRGAVGLVPAIFITLGILLGQvlg 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 160 LSDTAFSYSGaWRWMLGVIIIPAILLLIGVFFLPDSPRW-FAAKRRFHDAERVLLRLR---DTSAEAKNELEEIRESLKV 235
Cdd:cd17432  163 LRELLGNEEG-WPLLLALTGVPALLQLLTLPFFPESPRYlLIEKGDEEAARKALQRLRgkeDVDDEMEEMLEEQRAEKGV 241
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 236 KQ-SGWALFKENSnFRRAVFLGVLLQIMQQFTGMNVIMYYAPKIFELAGYTNTTEQmWGTVIVGLTNVLATFIAIGLVDR 314
Cdd:cd17432  242 GTvSVLELFRDRS-VRWQLISIIVLMAGQQLCGINAIYFYADSIFLEAGIPEDKIQ-YVTVGTGACEVLATITCVLVIER 319
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 315 WGRKPTLTLGFLVMAVGMGVLGTMMHMGIHSPTAQYFAVAMLLMFIIGFAMSAGPLIWVLCSEI--QPLKGRDFGITCSt 392
Cdd:cd17432  320 LGRRPLLIGGFGLMAVWCAVLTVALSLQNTVSWMPYLSIVCIFAYIASFGIGPAGVPFILTTEIfdQSSRPAAFMVAGS- 398
                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*....
gi 505384730 393 aTNWIANMIVGATFLTMLNTLGnANTFWVYAGLNLFFIVLTIWLVPETK 441
Cdd:cd17432  399 -LNWLSNFLVGLLFPFIQEGLG-AYCFLVFAVICLLTAIYIFFVLPETK 445
MFS_GLUT6_Class3 cd17434
Glucose transporter type 6, a Class 3 GLUT, of the Major Facilitator Superfamily of ...
17-446 3.05e-47

Glucose transporter type 6, a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 6 (GLUT6) is also called Solute carrier family 2, facilitated glucose transporter member 6 (SLC2A6). It is classified as a Class 3 GLUT protein, and is a facilitative glucose transporter that binds cytochalasin B with low affinity. It is found in the brain, spleen, and leucocytes. GLUT6 may function in oxalate secretion. SLC2A6 has been identified as an oxalate nephrolithiasis gene in mice; its deletion causes spontaneous calcium oxalate nephrolithiasis in the setting of hyperoxalaemia, hyperoxaluria, and nephrocalcinosis. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340992 [Multi-domain]  Cd Length: 417  Bit Score: 168.09  E-value: 3.05e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  17 FFVCFLAALAGLLFGLDIGVIAGALPFI----TDEFQISAHTQEWVVSSMMFGAAVGAVGSGWLSFKLGRKKSLMIGAIL 92
Cdd:cd17434    1 FLAVFSAVLGNFSFGYALVYTSPVIPALeqgdDPRLHLNVHQISWFGSVFTLGAAAGGLSAMFLNDRLGRKLSIMFSAVP 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  93 FVAGSLFSAAAPNVEVLIISRVLLGLAVGVASYTAPLYLSEIAPEKIRGSMISMYQLMITIGILGAYlsdtAFSYSGAWR 172
Cdd:cd17434   81 SALGYLLMGSAQGIWMLLLGRFLTGFAGGITAASIPVYVSEISHPGVRGALGACPQIMAVFGSLALY----ALGLLLPWR 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 173 WMLGVIIIPAILLLIGVFFLPDSPRWFAAKRRFHDAERVLLRLRDTSAEAKNELEEIRESLKVKQS--GWALFKENSNFr 250
Cdd:cd17434  157 WLAVAGEVPVVIMILLLCFMPNSPRFLISKGKDEKALKALAWLRGPNTDYMTEFEQIKDNIRKQSSrlSWAELKTPSYY- 235
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 251 RAVFLGVLLQIMQQFTGMNVIMYYAPKIFELAGYtnTTEQMWGTVIVGLTNVLATFIAIGLVDRWGRKPTLTLGFLVMAV 330
Cdd:cd17434  236 KPILIAVVMRFLQQLTGITPILVYLEPIFHLTAV--ILEPKYDAALVGAVRLLSVAIAASLMDKAGRKILLFTSAFLMFA 313
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 331 GMGVLGTMMHMGIhsptaqyfavamlLMFIIGFAMSAGPLIWVLCSEIQPLKGRDFGITCSTATNWIANMIVGATFLTML 410
Cdd:cd17434  314 ANLSMGLIPLIAA-------------MLFIMGYAMGWGPITWLLMSEILPLKARGVASGLCVVVSWITAFVLTQLFLPVV 380
                        410       420       430
                 ....*....|....*....|....*....|....*.
gi 505384730 411 NTLGNANTFWVYAGLNLFFIVLTIWLVPETKHVSLE 446
Cdd:cd17434  381 VTFGLQVPFLFFAAVCAVSIIFTACCVPETKGRTLE 416
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
10-399 9.27e-38

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 140.88  E-value: 9.27e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  10 TSNKAMTFFVCFLAALAGLLFGLDIGVIAGALPFITDEFQISAHTQEWVVSSMMFGAAVGAVGSGWLSFKLGRKKSLMIG 89
Cdd:COG2814    2 PATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLG 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  90 AILFVAGSLFSAAAPNVEVLIISRVLLGLAVGVASYTAPLYLSEIAPEKIRGSMISMYQLMITIGILGAYLSDTAFSYSG 169
Cdd:COG2814   82 LLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLF 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 170 AWRWMLGVIIIPAILLLIGV-FFLPDSPRwfAAKRRFHDAERVLLRlrdtsaeakneleeireslkvkqsgwalfkensn 248
Cdd:COG2814  162 GWRWVFLVNAVLALLALLLLlRLLPESRP--AARARLRGSLRELLR---------------------------------- 205
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 249 fRRAVFLGVLLQIMQQFTGMNVIMYYAPKIFELAGYTnTTEQMWGTVIVGLTNVLATFIAIGLVDRWGRKPTLTLGFLVM 328
Cdd:COG2814  206 -RPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLS-ASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLL 283
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 505384730 329 AVGMGVLGtmmhmgihspTAQYFAVAMLLMFIIGFAMS-AGPLIWVLCSEIQPLKGRDFGITCSTATNWIAN 399
Cdd:COG2814  284 ALGLLLLA----------LAGSLWLLLLALFLLGFGFGlLFPLLQALVAELAPPEARGRASGLYNSAFFLGG 345
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
18-222 6.68e-31

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 120.69  E-value: 6.68e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  18 FVCFLAALAGLLFGLDIGVIAGALPFITDEFQISAHTQEWVVSSMMFGAAVGAVGSGWLSFKLGRKKSLMIGAILFVAGS 97
Cdd:COG0477   14 RALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLAS 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  98 LFSAAAPNVEVLIISRVLLGLAVGVASYTAPLYLSEIAPEKIRGSMISMYQLMITIGILGAYLSDTAFSYSGAWRWMLGV 177
Cdd:COG0477   94 LLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLI 173
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 505384730 178 IIIPAILLLIGVFFLPDSPRWFAAKRRFHDAERVLLRLRDTSAEA 222
Cdd:COG0477  174 NAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLAL 218
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
21-434 8.97e-26

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 108.02  E-value: 8.97e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  21 FLAALAGLLFGLDIGVIAGALPFITDEFQISAHTQEWVVSSMMFGAAVGAVGSGWLSFKLGRKKSLMIGAILFVAGSLFS 100
Cdd:cd17324    2 LALALAAFAIGTTEYVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLA 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 101 AAAPNVEVLIISRVLLGLAVGVASYTAPLYLSEIAPEKIRGSMISMYQLMITIGILGAYLSDTAFSYSGAWRWMLGVIII 180
Cdd:cd17324   82 ALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAV 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 181 PAILLLIGV-FFLPDSPRwfaakrrfhdaervllrlrdtsaeakneleEIRESLKVKQSGWALFKensnfRRAVFLGVLL 259
Cdd:cd17324  162 LALLAALLLwRLLPSLPP------------------------------KKPGSLGLLSSLLLLLR-----NPRLRLAYLI 206
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 260 QIMQqFTGMNVIMYYAPKIFELAGYTNTTEQMWGTVIVGLTNVLATFIAIGLVDRWGRKPTLTLGFLVMAVGMGVLGtmm 339
Cdd:cd17324  207 TFLL-FGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTL--- 282
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 340 hmgihspTAQYFAVAMLLMFIIGFAM-SAGPLIWVLCSEIQPlKGRDFGITCSTATNWIANMIVGATFLTMLNTLGNANT 418
Cdd:cd17324  283 -------LGPSPLLLLVGLVLWGLGFfAAHSALQTRVLRLAP-EARGLASSLYLAAYNLGGALGAALGGLVLDHGGWAGV 354
                        410
                 ....*....|....*.
gi 505384730 419 FWVYAGLNLFFIVLTI 434
Cdd:cd17324  355 GWVGAALLLLALLLAL 370
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
10-441 3.64e-25

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 106.11  E-value: 3.64e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  10 TSNKAMTFFVCFLAALAGLLFGLDIGVIAGALPFITDEFQISAHTQEWVVSSMMFGAAVGAVGSGWLSFKLGRKKSLMIG 89
Cdd:COG2271    2 RAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIG 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  90 AILFVAGSLFSAAAPNVEVLIISRVLLGLAVGVASYTAPLYLSEIAPEKIRGSMISMYQLMITIGILGAYLSDTAFSYSG 169
Cdd:COG2271   82 LLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAF 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 170 AWRWMLGViiipailllIGVFFLpdsprwfaakrrfhdaervllrlrdtsaeakneleeireslkvkqsGWALFKensnf 249
Cdd:COG2271  162 GWRAAFLI---------LGLPGL----------------------------------------------LLALLR----- 181
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 250 rravFLGVLLQIMQQFTGMNVIMYYAPKIFELAGYTNTTEQMWGTVIVGLTNVLATFIAIGLVDRWGR--KPTLTLGFLV 327
Cdd:COG2271  182 ----FWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRrrKLVLAIGLLL 257
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 328 MAVGMGVLGTMMHMgihsptaqyfAVAMLLMFIIGFAMSAG-PLIWVLCSEIQPLKGRDFGITCSTATNWIANMIVGATF 406
Cdd:COG2271  258 AALALLLLALLPSP----------ALAIALLFLAGFGLGGAfGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLV 327
                        410       420       430
                 ....*....|....*....|....*....|....*
gi 505384730 407 LTMLNTLGNANTFWVYAGLNLFFIVLTIWLVPETK 441
Cdd:COG2271  328 GYLLDATGYQAAFLLLAALALLAALLALLLLRETR 362
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
16-362 4.41e-25

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 106.67  E-value: 4.41e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730   16 TFFVCFLAALaglLFGLDIGVIAGALPFITDEFQISAHTQEWVVSSMMFGAAVGAVGSGWLSFKLGRKKSLMIGAILFVA 95
Cdd:TIGR00895  18 AIILSFLIML---MDGYDLAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSV 94
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730   96 GSLFSAAAPNVEVLIISRVLLGLAVGVASYTAPLYLSEIAPEKIRGSMISMYQLMITIG-ILGAYLSDTAFSYSGaWRWM 174
Cdd:TIGR00895  95 FTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGaAVGGFLAGWLIPVFG-WRSL 173
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  175 LGVIIIPAILLLIGV-FFLPDSPRWFAAKRRFHDAERVLLRLRDTSAEAKNELEEIRESLKVKQSGWALFKENSNFRRAV 253
Cdd:TIGR00895 174 FYVGGIAPLLLLLLLmRFLPESIDFLVSKRPETVRRIVNAIAPQMQAEAQSALPEQKSTQGTKRSVFKALFQGKTARITV 253
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  254 FLGVLlqimqqfTGMNVIMYYA-----PKIFELAGYtNTTEQMWGTVIVGLTNVLATFIAIGLVDRWGRKPTlTLGFLVM 328
Cdd:TIGR00895 254 LLWLL-------YFMLLVGVYFltnwlPKLMVELGF-SLSLAATGGALFNFGGVIGSIIFGWLADRLGPRVT-ALLLLLG 324
                         330       340       350
                  ....*....|....*....|....*....|....
gi 505384730  329 AVGMGVLGTMMhmgiHSPTAQYFAVAMLLMFIIG 362
Cdd:TIGR00895 325 AVFAVLVGSTL----FSPTLLLLLGAIAGFFVNG 354
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
21-435 7.93e-25

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 104.99  E-value: 7.93e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  21 FLAALAGLLFGLDIGVIAGALPFITDEF--QISAHTQEWVVSSMMFGAAVGAVGSGWLSFKLGRKKSLMIGAILFVAGSL 98
Cdd:cd17316    2 LLAGLGWFFDAYDFFLIGFVAPVLAAEFslGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATL 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  99 FSAAAPNVEVLIISRVLLGLAVGVASYTAPLYLSEIAPEKIRGSMISMYQLMITIGILGAYLSDTAFSYSG----AWRWM 174
Cdd:cd17316   82 LIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLsgdwGWRIL 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 175 LGViiipaiLLLIGVFFLPdsprwfaakrrfhdaervllrlrdtsaeakneleeireslkvkqsgwalfkensnFRRAVF 254
Cdd:cd17316  162 FLI------GALPALLALL-------------------------------------------------------LRRRTL 180
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 255 LGVLLQIMQQFtGMNVIMYYAPKIFELAGYTNTTEQMWGTVIVGLTNVLATFIAIGLVDRWGRKPTLTLGFLVMAVGMGV 334
Cdd:cd17316  181 LLILLWFFISF-GYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALP 259
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 335 LGTMMHMGIhsptaqyFAVAMLLMFIIGFAMSAGPLIWVLCSEIQPLKGRDFGITCSTATNWIANMIVGATFLTMLNTLG 414
Cdd:cd17316  260 LFYLLSGSP-------TLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTG 332
                        410       420
                 ....*....|....*....|.
gi 505384730 415 NANTFWVYAGLNLFFIVLTIW 435
Cdd:cd17316  333 GTGVPALILALLAIVALIVAL 353
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
23-434 4.41e-24

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 103.28  E-value: 4.41e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  23 AALAGLLFGLDIGVIAGALPFITDEFQISAHTQEWVVSSMMFGAAVGAVGSGWLSFKLGRKKSLMIGAILFVAGSLFSAA 102
Cdd:cd06174    1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 103 APNVEVLIISRVLLGLAVGVASYTAPLYLSEIAPEKIRGSMISMYQLMITIG-ILGAYLSDTAFSYSGA-WRWMLGVIII 180
Cdd:cd06174   81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGgILGPLLGGILASSLGFgWRAVFLIAAA 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 181 PAILLLIGVFFLPDSPRWfaakrrfhdaervllrlrdtsaeAKNELEEIRESLKVKQSGWALFKensnfRRAVFLGVLLQ 260
Cdd:cd06174  161 LALLAAILLLLVVPDPPE-----------------------SARAKNEEASSKSVLKLLKRVLK-----NPGLWLLLLAI 212
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 261 IMQQFTGMNVIMYYAPKIFELAGYTNTTEqMWGTVIVGLTNVLATFIAIGLVDR-WGRKPTLTLGFLVMAVGMGVLGTMM 339
Cdd:cd06174  213 FLVNLAYYSFSTLLPLFLLDLGGLSVAVA-GLLLSLFGLAGALGSLLLGLLSDRlIGRKPLLLIGLLLMALGLALLLLAP 291
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 340 HmgihsptaqyFAVAMLLMFIIGFAMSAG-PLIWVLCSEIQPLKGRDFGITCSTATNWIANMIVGATFLTMLN-TLGNAN 417
Cdd:cd06174  292 S----------LLLLLLLLLLLGFGLGGLlPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAaTFGLTG 361
                        410
                 ....*....|....*..
gi 505384730 418 TFWVYAGLNLFFIVLTI 434
Cdd:cd06174  362 AFLVLAVLLLLAAILLL 378
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
60-446 3.71e-22

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 98.93  E-value: 3.71e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730   60 SSMMFGAAVGAVGSGWLSFKLGRKKSLMIgAILFVAGS-LFSAAAPNVEVLIISRVLLGLAVGVASYTAPLYLSEIAPEK 138
Cdd:TIGR00898 134 SCFFVGVLLGSFVFGYLSDRFGRKKVLLL-STLVTAVSgVLTAFSPNYTVFLVFRLLVGMGIGGIWVQAVVLNTEFLPKK 212
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  139 IRGSMISMYQLMITIGILGayLSDTAFSYSGaWRWMLGVIIIPAILLLIGVFFLPDSPRWFAAKRRFHDAERVLLRLRDT 218
Cdd:TIGR00898 213 QRAIVGTLIQVFFSLGLVL--LPLVAYFIPD-WRWLQLAVSLPTFLFFLLSWFVPESPRWLISQGRIEEALKILQRIAKI 289
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  219 -----SAEAKNELEEIRESLKVKQSGWALFKENSNFRRavflgVLLQIMQQFTGMNVIMYYAPKIFELAG---Ytntteq 290
Cdd:TIGR00898 290 ngkklPAEVLSLSLEKDLSSSKKQYSFLDLFRTPNLRK-----TTLCLMMLWFTTAFSYYGLVLDLGNLGgniY------ 358
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  291 mWGTVIVGLTNVLATFIAIGLVDRWGRKPTLTLGFLVMAVGMGVLGTMMHMgihsptaQYFAVAMLLMFIIGFAMSAGPL 370
Cdd:TIGR00898 359 -LDLFISGLVELPAKLITLLLIDRLGRRYTMAASLLLAGVALLLLLFVPVD-------LYFLRTALAVLGKFGITSAFQM 430
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  371 IWVLCSEIQPLKGRDFGI-TCSTATNwianmiVGATFLTMLNTLGNANTFW---VYAGLNLFFIVLTIWLvPETKHVSLE 446
Cdd:TIGR00898 431 VYLYTAELYPTVVRNLGVgVCSTMAR------VGSIISPFLVYLGEKWLFLplvLFGGLALLAGILTLFL-PETKGVPLP 503
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
24-437 7.71e-21

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 93.79  E-value: 7.71e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  24 ALAGLLFGLDIGVIAGALPFITDEFQISAHTQEWVVSSMMFGAAVGAVGSGWLSFKLGRKKSLMIGAILFVAGSLFSAAA 103
Cdd:cd17325    2 SLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFA 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 104 PNVEVLIISRVLLGLAVGVASYTAPLYLSEIAPEKIRGSMISMYQLMITIGILGAYLSDTAFSYSGAWRWMLGVIIIPAI 183
Cdd:cd17325   82 TSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALAL 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 184 LLLIGVFFLPDSPRWFAAKRRFHDAERVLLRLRDtsaeakneleeireslkvkqsgwalfkensnFRRAVFLGVLLQIMQ 263
Cdd:cd17325  162 LALVLALLLLPEPRPPPNKRAVSAARLRSGLRLL-------------------------------LRDRRLLALFLAIFV 210
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 264 QFTGMNVIMYYAPkiFELAGYTNTTEQMWGTV--IVGLTNVLATFIAIGLVDRWGRKPTLTLGFLVMAVGMGVLGTMmhm 341
Cdd:cd17325  211 LAFAFGALEPFLP--LYAAELGGLSPAQIGLLfgAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLA--- 285
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 342 gihspTAQYFAVAMLLMFIIGFAMSAGPLIWVLCSEIQP-LKGRDFGITcSTATNwiANMIVGATFLTML-NTLGNANTF 419
Cdd:cd17325  286 -----TSFWLLLLLLALLGLGLGLVFPATLALLADIVPPeGRGTAMGLF-NTAFS--LGMVLGPLLGGFLyDAFGFATPF 357
                        410
                 ....*....|....*...
gi 505384730 420 WVYAGLNLFFIVLTIWLV 437
Cdd:cd17325  358 LAAAALLLLAAVLFLLLR 375
MFS_1 pfam07690
Major Facilitator Superfamily;
24-401 1.07e-20

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 92.87  E-value: 1.07e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730   24 ALAGLLFGLDIGVIAGALP-FITDEFQISAHTQEWVVSSMMFGAAVGAVGSGWLSFKLGRKKSLMIGAILFVAGSLFSAA 102
Cdd:pfam07690   2 FLAAFLAALGRSLLGPALPlLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLF 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  103 APNVEVLIISRVLLGLAVGVASYTAPLYLSEIAPEKIRGSMISMYQLMITIGILGAYLSDTAFSYSGAWRWMLGVIIIPA 182
Cdd:pfam07690  82 ASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILS 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  183 ILLLIGVFFLPDSPrwfaakrrfhdaervllrlrdtsaeakneleEIRESLKVKQSGWALFKENSNFRRAVFLGVLLQIM 262
Cdd:pfam07690 162 LLAAVLLLLPRPPP-------------------------------ESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALL 210
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  263 QQFTGMNVIMYYAPKIFELAGYTNTTEqMWGTVIVGLTNVLATFIAIGLVDRWGRKPTLTLGFLVMAVGMGVLgtmmhmg 342
Cdd:pfam07690 211 LFGFAFFGLLTYLPLYQEVLGLSALLA-GLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGL------- 282
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  343 IHSPTAQYFAVAMLLMFIIGFAMS-AGPLIWVLCSEIQPLKGRDFGITCSTATNWIANMI 401
Cdd:pfam07690 283 LLLSLTLSSLWLLLALLLLGFGFGlVFPALNALVSDLAPKEERGTASGLYNTAGSLGGAL 342
MFS_PhT cd17364
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This ...
24-440 1.33e-20

Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of predominantly fungal and plant high-affinity inorganic phosphate transporters (PhT or PiPT), which are involved in the uptake, translocation, and internal transport of inorganic phosphate. They also function in sensing external phosphate levels as transceptors. Phosphate is crucial for structural and metabolic needs, including nucleotide and lipid synthesis, signalling and chemical energy storage. The Pht subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340922 [Multi-domain]  Cd Length: 389  Bit Score: 93.11  E-value: 1.33e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  24 ALAGLLF---GLDIGVIAGALPFITDEFQISAHTQEWVVSSMM-----FGAAVGAVGSGWLSFKLGRKKSLMIGAILFVA 95
Cdd:cd17364    2 IIAGMGFftdAYDLFSISLVTKILGRLYYGGKGSLPSGVSGLVnaaalVGTIIGQLFFGFLGDRFGRKRVYGVELIIMII 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  96 GSLFSAAAPNVEV------LIISRVLLGLAVGVASYTAPLYLSEIAPEKIRGSMISMYQLMITIGIL------------- 156
Cdd:cd17364   82 GTILSALSPGSTPlgvmgwLIFFRFLLGIGIGGDYPLSATIMSEYANKKRRGALIAAVFAMQGFGILagaivtlilsaif 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 157 -GAYLSDTAFSYSGAWRWMLGVIIIPAIllliGVFFLpdsprwfaakrRFHdaervllrlrdtsaeakneleeiresLKV 235
Cdd:cd17364  162 eHPLPAGTYHHADLVWRIVLGLGAIPAL----SVLYF-----------RKH--------------------------LLG 200
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 236 KQSGWALFkENSNFRRAVFLGVLLQIMQQFTGMNVIMyyapkifelAGYTNTTEQmwgTVIVGLTNVLATFIAIGLVDRW 315
Cdd:cd17364  201 TAGTWFLL-DIAFYGQNLFQSTIISAIGFSKTMNAYQ---------ELFNIAVGQ---LIIALAGTVPGYWFTVFLIDRI 267
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 316 GRKPTLTLGFLVMAVGMGVLGTMMHMGIHSPTAqYFAVAMLLMFIigFAMSAGPLIWVLCSEIQPLKGRDFGITCSTATN 395
Cdd:cd17364  268 GRKKIQMMGFFGMTIFLLILAGPYDHWKISTIG-FFVLYGLTFFF--SNFGPNTTTFIVPAEVFPARVRSTCHGISAASG 344
                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*
gi 505384730 396 WIANMIVGATFLTMLNTLGNANTFWVYAGLNLFFIVLTIWLVPET 440
Cdd:cd17364  345 KIGAIVGSFLFLSLTQNIGVRNVLIILAGVALLGIILTLLFPEEK 389
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
23-367 6.51e-20

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 91.10  E-value: 6.51e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  23 AALAGLLFGLDIGVIAGALPFITDEFQISAHTQEWVVSSMMFGAAVGAVGSGWLSFKLGRKKSLMIGAILFVAGSLFSAA 102
Cdd:cd17503    1 LLLGAFMAILDTTIVNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 103 APNVEVLIISRVLLGLAVGVASYTAPLYLSEIAPEKIRGSMISMYQLMITIG-----ILGAYLSDTAfsysgAWRWMLGV 177
Cdd:cd17503   81 APNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLApaigpTLGGWLTDNL-----SWRWIFYI 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 178 iiiPAILLLIGVFFLPdsprwfaakrrfhdaervLLRLRdtsaeakneleeireslkvkqsgwaLFKeNSNFRRAVFLGV 257
Cdd:cd17503  156 ---NLPIGILALLLAP------------------LLDLR-------------------------LFK-DRNFTLGLLLSF 188
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 258 LLQImqqftGMNVIMYYAPKIFE-LAGYTnTTEQMWGTVIVGLTNVLATFIAIGLVDRWGRKPTLTLGFLVMAVGMGVlg 336
Cdd:cd17503  189 LLGL-----GLFGAMFLLPLYLQnVLGYS-AFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGLLLLALGTLL-- 260
                        330       340       350
                 ....*....|....*....|....*....|.
gi 505384730 337 tMMHMGIHSPTAQYFAVAMLLMFIIGFAMSA 367
Cdd:cd17503  261 -LAFLTPDTSLWLIILPLFIRGLGMGLVFMP 290
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
19-444 5.23e-19

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 88.40  E-value: 5.23e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  19 VCFLAALAGLLFGLDIGVIAGALPFITDEFQISAHTQEWVVSSMMFGAAVGAVGSGWLSFKLGRKKSLMIGAILFVAGSL 98
Cdd:COG2223    6 VLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLL 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  99 FSAAAPNVEVLIISRVLLGLAVGvASYTAPL-YLSEIAPEKIRGSMISMYQLMITIGILGAYLSDTAFSYSGAWRWMLGV 177
Cdd:COG2223   86 LLALAVSYWLLLLLGLLLGIGGG-GSFAVGIaLVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLI 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 178 IIIPAILLLIGV-FFLPDSPrwfaakrrfhdaervllrlRDTSAEAKNELEEIRESLKVKQSgWALFkensnfrrAVFLG 256
Cdd:COG2223  165 LGILLLVVAVLAwLFLRDPP-------------------AGAAAAAKASLRDQLEALRDPRF-WLLS--------LLYFG 216
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 257 VllqimqqFTGMNVIMYYAPKIFELAGYTNTTEQMWGTVIVGLTNVLATFIAIGLVDRWGRKPTLTLGFLVMAVGMGVLG 336
Cdd:COG2223  217 T-------FGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLA 289
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 337 TMMHMgihsptaqyFAVAMLLMFIIGFAMSAG-PLIWVLCSEIQPLKGRDFGITCSTATNWIANMIVGATFLTMLNTLGN 415
Cdd:COG2223  290 LALGS---------LWLFLVLFLLLGLALGGGnGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGS 360
                        410       420       430
                 ....*....|....*....|....*....|
gi 505384730 416 -ANTFWVYAGLNLFFIVLTIWLVPETKHVS 444
Cdd:COG2223  361 yTAAFLVFAVLALVALVLTLLLYRRPRRAA 390
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
24-370 1.62e-18

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 86.84  E-value: 1.62e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  24 ALAGLLFGLDIGVIAGALPFITDEFQISAHTQEWVVSSMMFGAAVGAVGSGWLSFKLGRKKSLMIGAILFVAGSLFSAAA 103
Cdd:cd17321    2 LLAVFLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALA 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 104 PNVEVLIISRVLLGLAVGVASYTAPLYLSEIAPEKIRGSMISMYQLMITIG-ILGAYLSDTAFSYSGaWRWMLGViiiPA 182
Cdd:cd17321   82 PSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGaALGPLLGGLLLELFG-WRWIFLI---NV 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 183 ILLLIGVFFLPdsprwfaakrrfhdaervllrlrdtsaeakneleeireslkvkqsgwalfkensNFRRAVFLGVLLqim 262
Cdd:cd17321  158 PIGLVALLLAR------------------------------------------------------TFSGAVLAAFLL--- 180
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 263 qqFTGMNVIMYYAPKIFELAGYTNTTEQMWGTVIVGLTNVLATFIAIGLVDRWGRKPTLTLGFLVMAVGMGVLgtmmhMG 342
Cdd:cd17321  181 --GAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLLLL-----AL 253
                        330       340
                 ....*....|....*....|....*...
gi 505384730 343 IHSPTAQYFAVAMLLMFIIGFAMSAGPL 370
Cdd:cd17321  254 LGADSSVWLLLPGLVLLGLGLGLFATPL 281
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
20-440 7.50e-17

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 81.96  E-value: 7.50e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  20 CFLAALAGLLFGLDIGVIAGALPFITDEFQISAHTQEWVVSSMMFGAAVGAVGSGWLSFKLGRKKSLMIGAILFVAGSLF 99
Cdd:cd17371    1 FWAAFLGWALDGFDLLLLGLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 100 SAAAPNVEVLIISRVLLGLAVGVASYTAPLYLSEIAPEKIRGSMISMYQLMITIGILGAYLSDT-AFSYSG---AWRWML 175
Cdd:cd17371   81 CGFAQNYWQLLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAAlLFPLLPpeiAWRVLF 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 176 GVIIIPAILLLIGVFFLPDSPRWFAAKRRfhdaervllrlrdtsaeakneleeiRESLKVKQSGWALFkeNSNFRRAVFL 255
Cdd:cd17371  161 LLGALPALLVLFIRRFVKEPPQWQAARAA-------------------------RRHFADRPSLRELF--SPPLLRTTLL 213
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 256 GVLLQIMQQFTGMNVIMYYaPKIFELAGYTNTTEQMWGTVIVGLTNVLATFIAIGLVDRWGRKPTLTLGFLVMAVGMgVL 335
Cdd:cd17371  214 ASLLATGALGGYYGITTWL-PSYLTGERGLSFEGSAGYLVVTILGGFLGYLAGGFLADRIGRRNNFALFALGSAISI-LL 291
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 336 GTMMHMGihsptaqyFAVAMLLMFIIGFAMSAGPLIW-VLCSEIQPLKGRDfgiTCSTATNWIANMI-----VGATFLTM 409
Cdd:cd17371  292 YFFLPLS--------PTLILILGFPLGFFASGPFSGMgAYLTELFPTAVRA---TAQGFCYNVGRIIgalfpFLVGFLAT 360
                        410       420       430
                 ....*....|....*....|....*....|.
gi 505384730 410 LNTLGNAntFWVYAGLNLFFIVLTIWLVPET 440
Cdd:cd17371  361 SGSLGTA--IAVFAAVYYIAGLVLALLLPET 389
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
18-362 1.09e-15

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 78.01  E-value: 1.09e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  18 FVCFLAALaglLFGLDIGVIAGALPFITDEFQISAHTQEWVVSSMMFGAAVGAVGSGWLSFKLGRKKSLMIGAILFVAGS 97
Cdd:cd17365    2 ALCFLIIV---LDGFDLAVMGFVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFT 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  98 LFSAAAPNVEVLIISRVLLGLAVGVASYTAPLYLSEIAPEKIRGSMISMYQLMITIG-ILGAYLSdTAFSYSGAWRWMLg 176
Cdd:cd17365   79 LLTAFAQSVLQLALLRFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGaALGGFLA-AALIPAFGWRSVF- 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 177 viiipAILLLIGVFFLPdsprwfaakrrfhdAERVLLRLrdtsaeakneleeireslkvkqsgWALFkensnfrravFLG 256
Cdd:cd17365  157 -----LLGGVPPLILLP--------------LLRGTLLL------------------------WVTF----------FMG 183
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 257 VLLqimqqFTGMNVimyYAPKIFELAGYTnTTEQMWGTVIVGLTNVLATFIAIGLVDRWGRKPTLTLGFLVMAVGMGVLG 336
Cdd:cd17365  184 LLL-----VYLLNS---WLPKLMVEAGYS-LSQALTITLLLNIGGVIGSLLLGWLADRFGPKRVLALFFALGAVSLALLG 254
                        330       340
                 ....*....|....*....|....*.
gi 505384730 337 TMMhmgiHSPTAQYFAVAMLLMFIIG 362
Cdd:cd17365  255 VSP----ASLVLLYVLVFLAGACVNG 276
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
24-174 6.81e-15

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 76.08  E-value: 6.81e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  24 ALAGLLFGLDIGVIAGALPFITDEFQISAHTQEWVVSSMMFGAAVGAVGSGWLSFKLGRKKSLMIGAILFVAGSLFSAAA 103
Cdd:cd17504    2 ALAALAVMLVETMLSPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFA 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 104 PNVEVLIISRVLLGLAVGVasytAPLYLS----EIAPEKIrGSMISMYQLMITIG-----ILGAYLSDTAfsysgAWRWM 174
Cdd:cd17504   82 PNLPVLIAGRALQGIGGAV----FPLAFAlvreEFPPERV-PVAQGILSATFGIGagiglPLGGWIVQHL-----GWRWI 151
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
25-436 1.33e-14

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 74.52  E-value: 1.33e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  25 LAGLLFGLDIGVIAGALPFITDEFQiSAHTQEWVVSSMMFGAAVGAVGSGWLSFKLGRKKSLMIGAILFVAGSLFSAAAP 104
Cdd:cd17502    3 LALFLAALDQTIVATALPTIVAEFG-GLSLVSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAP 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 105 NVEVLIISRVLLGLAVGVASYTAPLYLSEIAPEKIRGSMISMYQLMITIG-----ILGAYLSDTAfsysgAWRWmlgvii 179
Cdd:cd17502   82 NMTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPRERGKYQGYIGAVFGIAsvagpLIGGAFTDHL-----SWRW------ 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 180 ipaillligVFFlpdsprwfaakrrfhdaervllrlrdtsaeakneleeiresLKVKQSGWALFkensnFRRAVFLGVLL 259
Cdd:cd17502  151 ---------CFY-----------------------------------------INLPIGGLALA-----LLRTILLSSIF 175
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 260 QIMQQFtGMNVIMYYAPKIFELAGYTNTTEQMWGTVIVGLTNVLATFIAIGLVDRWGR-KPTLTLGFLVMAVGMGVLGTM 338
Cdd:cd17502  176 GFLFGG-ALFGLIYYLPLYFQLVLGDSATKSGVRLLPLIIGLVIGSIISGALISKTGRyKPLIVIGTILMSVGAGLLTTL 254
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 339 MHmgiHSPTAQYFAVAMLLMFIIGFAMSAGPLiwvlcSEIQPLKGRDFGItcSTATNWIANMIVGATFLTMLntlgnaNT 418
Cdd:cd17502  255 TL---DTSKWLLIGYLILLGLGLGIGFQQPLV-----AVQNAVPPADVGV--ATATNTFFRSLGGTLGVAIT------DV 318
                        410
                 ....*....|....*...
gi 505384730 419 FWVYAGLNLFFIVLTIWL 436
Cdd:cd17502  319 FLVALALAALAFLLSLFL 336
efflux_EmrB TIGR00711
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ...
16-174 3.49e-14

drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]


Pssm-ID: 129794 [Multi-domain]  Cd Length: 485  Bit Score: 74.34  E-value: 3.49e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730   16 TFFVCFLAALAGLLfglDIGVIAGALPFITDEFQISAHTQEWVVSSMMFGAAVGAVGSGWLSFKLGRKKSLMIGAILFVA 95
Cdd:TIGR00711   3 LTIVLMLGTFMAVL---DSTIVNVAIPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730   96 GSLFSAAAPNVEVLIISRVLLGLAVGVASYTAPLYLSEIAPEKIRGSMISMYQLMITIG-----ILGAYLSDTAfsysgA 170
Cdd:TIGR00711  80 GSLLCGVAPNLELMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVApalgpTLGGWIIENY-----H 154

                  ....
gi 505384730  171 WRWM 174
Cdd:TIGR00711 155 WRWI 158
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
21-374 7.89e-14

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 72.96  E-value: 7.89e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  21 FLAALAGLLFGLDIGVIAGALPFITDEFQISAHTQEWVVSSMMFGAAVGAVGSGWLSFKLGRKKSLMIGAILFVAGSLFS 100
Cdd:COG0738   11 IAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLF 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 101 AAAPNVEVLIISRVLLGLAVGVASYTAPLYLSEIAPEKiRGSMISMYQLMITIG-ILGAYLSDTAFSYSGAWRWMLGVII 179
Cdd:COG0738   91 ALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPET-AASRLNLLHAFFSLGaLLGPLLGGLLILLGLSLSWHLPYLI 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 180 IPAILLLIGVFFLpdsprwfaaKRRFHDAErvllrlrDTSAEAKNELEEIRESLKVKQSGWALFkensnfrrAVFLGVLL 259
Cdd:COG0738  170 LAVLLLLLALLFL---------RSKLPEIE-------EEEEEAAGSAASLKSLLKNPRLLLGGL--------AIFLYVGA 225
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 260 QIMqqftgmnvIMYYAPKIFELAGYTNTTEQMWGTVIVGLTNVLATFIAIGLVDRWGRKPTLTLGFLVMAVGMGVLGtmm 339
Cdd:COG0738  226 EGA--------IGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLAL--- 294
                        330       340       350
                 ....*....|....*....|....*....|....*.
gi 505384730 340 hmgihspTAQYFAVAMLLMFIIGFAMSAG-PLIWVL 374
Cdd:COG0738  295 -------LAPGPWLALIGLALVGLGLSLMfPTIFSL 323
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
40-366 1.59e-13

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 71.84  E-value: 1.59e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  40 ALPFITDEFQISAHTQEWVVSSMMFGAAVGAVGSGWLSFKLGRKKSLMIGAILFVAGSLFSAAAPNVEVLIISRVLLGLA 119
Cdd:cd17320   21 ALPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLG 100
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 120 VGVASYTAPLYLSEIAPEKIRGSMISMyqLMITIGI-------LGAYLSDTafsysGAWRWMLGVIIIPAILLLIGVFFL 192
Cdd:cd17320  101 AAAGSVVARAIVRDLYSGAELAKIFSL--LMMILAIapalaplLGGLLLLF-----FGWRAIFVFLALLGLLLLLLVLLF 173
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 193 pdsprwfaakrrfhdaervllrlrdtsaeakneLEEIRESLKVKQSGWALFKENSN-FRRAVFLGVLLQIMQQFTGMNVI 271
Cdd:cd17320  174 ---------------------------------LPETLPEEKRKPLLSSLLRAYKRvLKNRRFLGYALALGLSFAGLFAY 220
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 272 MYYAPKIFELAGYTNTTEQMWGTVIVGLTNVLATFIAIGLVDRWGRKPTLTLGFLVMAVGmGVLGTMMHMGIHSPTAQYF 351
Cdd:cd17320  221 LAAAPFIYIEQLGLSPAQFGLLFALNAIALILGSLLNGRLVRRFGPRRLLRLGLLLLLAA-ALVLLLAALLGGLSLWPLV 299
                        330
                 ....*....|....*
gi 505384730 352 AVAMLLMFIIGFAMS 366
Cdd:cd17320  300 APLFLIFFGFGLIFP 314
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
1-368 3.02e-13

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 71.06  E-value: 3.02e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730   1 MPDNNKQGRTSNKAMTFFVCFLAALAGLLFGLDIGVIAGALPFITDEFQISAHTQEWVVSSMMFGAAVGAVGSGWLSFKL 80
Cdd:COG2807    1 MSTTSSSARRSRRAGRWLLLLAIVLVALNLRPAITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  81 GRKKSLMIGAILFVAGSLFSAAAPNVEVLIISRVLLGLAVGVASYTAPLYLSEIAPEKIrGSMISMYQLMITIG-ILGAY 159
Cdd:COG2807   81 GLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWFPDRV-GLMTGLYTAAMGLGaALAAG 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 160 LSDTAFSYSGaWRWMLGVIIIPAIllligVFFLPdsprWFAAKRRfhdaervllrlRDTSAEAKNELEEIRESLKVKQsG 239
Cdd:COG2807  160 LTVPLAAALG-WRGALAVWALLAL-----LALLL----WLPLLRR-----------RPAAAAAAPAAASLRSLWRSPL-A 217
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 240 WALfkensnfrrAVFLGVllqimqQFTGMNVIMYYAPKIFELAGYTnTTEQMWGTVIVGLTNVLATFIAIGLVDRWG-RK 318
Cdd:COG2807  218 WLL---------TLFFGL------QSLLYYAVVAWLPPILRDAGLS-AATAGLLLSLFQLAGIPGSLLVPLLADRLGdRR 281
                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|
gi 505384730 319 PTLTLGFLVMAVGMGVLGTMmhmgihsPTAQYFAVAMLLMFIIGFAMSAG 368
Cdd:COG2807  282 PLLLLLGLLGLAGLLGLLLA-------PGSLPWLWAVLLGLGQGGLFPLA 324
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
56-436 6.96e-13

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 69.53  E-value: 6.96e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  56 EWVVSSMMFGAAVGAVGSGWLSFKLGRKKSLMIGAILFVAGSLFSAAAPNVEVLIISRVLLGLAVGVASYTAPLYLSEIA 135
Cdd:cd17317   28 ALVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVGFVLGMEIV 107
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 136 PEKIRGSMISMYQLMITIGILG----AYLSDTafsysgaWRWMLgviiipAILLLIGVFFLPDSprWFAAkrrfhdaerv 211
Cdd:cd17317  108 GPKYRSFVGILFGLFWALGYMLlallAYLIRD-------WRWLQ------LAISLPGLLFLLLL--WWLP---------- 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 212 llrlrdtsaeakneleeireslkvkqsgwalfkensnfRRAVFLGVLLqimqqftGMNVIMYYA--PKIFELAGYtntte 289
Cdd:cd17317  163 --------------------------------------RRTIIVGLIW-------FVTSLVYYGlsLNSSNLGGN----- 192
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 290 QMWGTVIVGLTNVLATFIAIGLVDRWGRKPTLtlgFLVMAVGMGVLGTMMHMGIHSPTAqyfavAMLLMFIIGFAMSAG- 368
Cdd:cd17317  193 LYLNFFLSGLVEIPAYFLALLLLDRLGRRWTL---SGSLLLAGLACLVTALLPDDENTL-----ALTLALVGKFAISAAf 264
                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 505384730 369 PLIWVLCSEIQPLKGRDFGI-TCSTATNWIAnmiVGATFLTMLNTLGNANTFWVYAGLNLFFIVLTIWL 436
Cdd:cd17317  265 SVIYLYTAELYPTVVRNTGVgLCSTVARVGA---ILAPFIVLLGKIGPLLPLIIFGVLALLGGLLTLLL 330
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
25-437 8.07e-13

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 69.55  E-value: 8.07e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  25 LAGLLFGLDIGVIAGALPFITDEFQISAHTQEWVVSSMMFGAAVGAVGSGWLSFKLGRKKSLMIGAILFVAGSLFSAAAP 104
Cdd:cd17489    3 LANFFFFLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLAT 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 105 NVEVLIISRVLLGLAVGVASYTAPLYLSEIAPEKIRGSMISMYQLMITIG-ILGAYLSDTAFSYSGAWrWMLGVIIIPAI 183
Cdd:cd17489   83 SVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAmALGPALGLFLYQHLGFA-VLFIVAAVLAL 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 184 LLLIGVFFLPDSPRwfaakrrfhdaervllrlrdtsaeakneleeireslKVKQSGWALFKENSNFRRAVFLGVLLQIMQ 263
Cdd:cd17489  162 LALLLVFLVKDPPP------------------------------------VAAEEAEAGTRAFRRLVEKKVLPPALILFL 205
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 264 QFTGMNVIMYYAPKIFELAGYTNTTEQMwgtVIVGLTNVLATFIAIGLVDRWGRKPTLTLGFLVMAVGMGVLGtmmhmgi 343
Cdd:cd17489  206 ASIAYGAISTFLPLYAAERGISNAGLFF---TVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLS------- 275
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 344 hspTAQYFAVAMLLMFIIGFAMSAG-PLIWVLCSEIQPLKGRdfGITCST-ATNWIANMIVGATFLTML-NTLGNANTFW 420
Cdd:cd17489  276 ---FAGSPWMLLLAAVLYGLGFGLLfPALQALAVDLVPPHRR--GAANGTfFIFFDLGIGLGGLLLGLVaELFGYRAMFL 350
                        410
                 ....*....|....*..
gi 505384730 421 VYAGLNLFFIVLTIWLV 437
Cdd:cd17489  351 LAAVVVLLALVLYIFLL 367
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
13-336 3.08e-12

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 67.98  E-value: 3.08e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  13 KAMTFFVCFLAALAgllfgldIGVIAGALPFITDEFQISAHTQEWVVSSMMFGAAVGAVGSGWLSFKLGRKKSLMIGAIL 92
Cdd:cd17474    1 LYAVFFATLLAVLG-------VSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLL 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  93 FVAGSLFSAAAPNVEVLIISRVLLGLAVGVASYTAPLYLSEIAPEKIRGSMISMYQLMITIG-----ILGAYLSDTafsy 167
Cdd:cd17474   74 FGIGGLLCGLSDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGiavgpLLGGLLAAI---- 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 168 sgAWRWMLGVIIIPAILLLIGVFFLPDSPrwfaakrrfhdaervllrlrdtsaeakneleeirESLKVKQSGWALFKENS 247
Cdd:cd17474  150 --SWRYPFFLLAALIPVAFLAILFLLPEP----------------------------------KEKAKSSSATKLRDLKK 193
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 248 NFRRAVFLGVLLQIMQQFTGMNVIMYYAPKIFELAGYtnTTEQMWGTVIVGLTNVLATFIAIG---LVDRWGRKPTLTLG 324
Cdd:cd17474  194 ALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYG--ISPIIIGLLFAGWSVLLALGSLFVgrlLKKRFGARRILVIG 271
                        330
                 ....*....|..
gi 505384730 325 FLVMAVGMGVLG 336
Cdd:cd17474  272 LLLYALSLLLLG 283
synapt_SV2 TIGR01299
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ...
17-236 3.94e-12

synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.


Pssm-ID: 130366 [Multi-domain]  Cd Length: 742  Bit Score: 68.46  E-value: 3.94e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730   17 FFVCFLAALAGllfGLDIGVIAGALPFITDEFQISAHTQEWVVSSMMFGAAVGAVGSGWLSFKLGRKKSLMIGAILFVAG 96
Cdd:TIGR01299 169 FFVLGLALMAD---GVEVFVVGFVLPSAEKDLCIPDSGKGMLGLIVYLGMMVGAFFWGGLADKLGRKQCLLICLSVNGFF 245
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730   97 SLFSAAAPNVEVLIISRVLLGLAVGVASYTAPLYLSEIAPEKIRGSMISMYQLMITIGilGAYLSDTA----------FS 166
Cdd:TIGR01299 246 AFFSSFVQGYGFFLFCRLLSGFGIGGAIPIVFSYFAEFLAQEKRGEHLSWLCMFWMIG--GIYAAAMAwaiiphygwsFQ 323
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 505384730  167 YSGA-----WRWMLGVIIIPAILLLIGVFFLPDSPRWFAAKRRFHDAERVLLRLRDTSAEAKNELEEIRESLKVK 236
Cdd:TIGR01299 324 MGSAyqfhsWRVFVIVCAFPCVFAIGALTFMPESPRFFLENGKHDEAWMILKLIHDTNMRAKGHPEKVFSVNHIK 398
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
21-224 5.42e-12

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 67.26  E-value: 5.42e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  21 FLAALAGLLFGLDIGVIAGALPFITDEFQISAHTQEWVVSSMMFGAAVGAVGSGWLSFKLGRKKSLMIGAILFVAGSLFS 100
Cdd:cd17328    2 AVLFLINLLNYMDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLS 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 101 AAAPNVEVLIISRVLLGlaVGVASYT--APLYLSEIAPEKIRGSMISMYQLMITIG-ILGAYLSDTAFSYSGAWRWMLGV 177
Cdd:cd17328   82 SFAPNFWQLLLFRALVG--IGEASYSpiAPTIIADLFPKEKRTRALGVFYFAIPLGsGLGYVVGGLVAQATGGWRWAFRV 159
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 505384730 178 IIIPAILLLIGVFFLPDSPRWFAAKRRFHDAERVLLRLRDTSAEAKN 224
Cdd:cd17328  160 TGVLGVLLAILLLLFVREPPRGAAEGGVMAKSTATSFLADLKALAKN 206
2A0109 TIGR00887
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the ...
65-450 9.52e-12

phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the major facilitator superfamily (pfam00083). [Transport and binding proteins, Anions]


Pssm-ID: 129965 [Multi-domain]  Cd Length: 502  Bit Score: 67.06  E-value: 9.52e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730   65 GAAVGAVGSGWLSFKLGRKKS------LMIGAILFVAGSLFSAAAPNVEVLIISRVLLGLAVGVASYTAPLYLSEIAPEK 138
Cdd:TIGR00887  68 GTLAGQLFFGWLADKLGRKRVygmeliIMIIATVASGLSPGSSPKSVMATLCFWRFWLGVGIGGDYPLSAIITSEFATKK 147
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  139 IRGSMISMYQLMITIGILG-------------------AYLSDTAFSYSGA----WRWMLGVIIIPAILLLIGVFFLPDS 195
Cdd:TIGR00887 148 WRGAMMAAVFAMQGFGILAgaivalivlagfkhsleaaADEASCTGSCVPAvdymWRILIGFGAVPALLALYFRLTIPET 227
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  196 PRWFA--AKRRFHDAERVLLRLRDTSAEAKNELEEIRESLKVKQSGWA-LFKENSNFRRA-VFLGV-----LLQImqQFT 266
Cdd:TIGR00887 228 PRYTAdvAKDVEQAASDMSAVLQVKIEAEPDEVEKASTAVEVPKASWSdFFTHFFKWRHGkHLLGTagswfLLDI--AFY 305
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  267 GMNVimyYAPKIFELAGYTNTTEQMWGTVIVGLTNVLATFIAIG-----------LVDRWGRKPTLTLGFLVMAVGMGVL 335
Cdd:TIGR00887 306 GVNL---NQKVILSAIGYSPPAATNNAYEELYKTAVGNLIIALAgtvpgywvtvfLVDIIGRKPIQLMGFFILTVLFFVL 382
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  336 GTMMHmgiHSPTAQYFAVAMLLMFIIGFAMSAGPLIwvLCSEIQPLKGRDFGITCSTATNWIANmIVGATFLTMLNTLGN 415
Cdd:TIGR00887 383 GFAYN---HLSTHGFLAIYVLAQFFANFGPNATTFI--VPGEVFPTRYRSTAHGISAASGKAGA-IIGQFGFLYLAQHGD 456
                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*.
gi 505384730  416 A-----------NTFWVYAGLNLFFIVLTIwLVPETKHVSLEHIER 450
Cdd:TIGR00887 457 PtkgyptgiwmgHVLEIFALFMFLGILFTL-LIPETKGKSLEELSG 501
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
20-173 4.72e-11

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 64.13  E-value: 4.72e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  20 CFLAALAGLLFGLDIGVIAGALPFITDEFQISAHTQEWVVSSMMFGAAVGAVGSGWLSFKLGRKKSLMIGAILFVAGSLF 99
Cdd:cd17323    1 VFIISFLTFVVTFGSSIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIG 80
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 505384730 100 SAAAPNVEVLIISRVLLGLAVGVASYTAPLYLSEIAPEKIRGSMISMYQLMITIG-----ILGAYLSDtafsySGAWRW 173
Cdd:cd17323   81 CALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGpalgpIIGGFITQ-----SLGWRW 154
MFS_SVOP_like cd17372
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator ...
22-193 5.78e-11

Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator Superfamily; This subfamily is composed of synaptic vesicle 2 (SV2)-related protein (SVOP), SVOP-like protein (SVOPL), and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP and SVOPL share structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. The SVOP-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340930 [Multi-domain]  Cd Length: 367  Bit Score: 63.71  E-value: 5.78e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  22 LAALAGLLFGLDIGVIAGALPFITDEFQISAHTQEWVVSSMMFGAAVGAVGSGWLSFKLGRKKSLMIGAILFVAGSLFSA 101
Cdd:cd17372    3 YAGMGWVAEAMEMMLLSFVGPAVQCEWNLSAWQVALITSVVFAGMMIGSYLWGIVSDKYGRRKGLIISALWTFYAGFLSA 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 102 AAPNVEVLIISRVLLGLAVGVASYTAPLYLsEIAPEKIRGSMISMYQLMITIG-ILGAYLSDTAFSYSGaWRWMLGVIII 180
Cdd:cd17372   83 FAPNYMWLIILRCLVGLGLGGGPQLASWYL-EFLPAKSRGTWMVLFSVFWTVGtIFEASLAWLVMPRLG-WRWLLAFSSV 160
                        170
                 ....*....|...
gi 505384730 181 PAILLLIGVFFLP 193
Cdd:cd17372  161 PSSLLLVFYRWTP 173
MFS_TRI12_like cd06179
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ...
18-173 9.38e-11

Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340868 [Multi-domain]  Cd Length: 518  Bit Score: 63.80  E-value: 9.38e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  18 FVCFLAALAGLLFGLdigVIAGALPFITDEFQISAhTQEWVVSSMMFGAAVGAVGSGWLSFKLGRKKSLMIGAILFVAGS 97
Cdd:cd06179    1 AALCLAYFAQLFGVT---LPAAVLPFIVADLGPSS-NSTWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGS 76
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 505384730  98 LFSAAAPNVEVLIISRVLLGLAVGvASYTAPLYLSEIAPEKIRGSMIS-MYQLMITIGILGAYLSDTAFSYSGA-WRW 173
Cdd:cd06179   77 IVAGTAKSVNMLIGGQALIGIGAG-TQGLGAAVASELVPNKYRGLVQGvVNLVASPGSALGPLIAGALVEANAAgWRW 153
PRK11551 PRK11551
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
9-147 1.15e-10

putative 3-hydroxyphenylpropionic transporter MhpT; Provisional


Pssm-ID: 236927 [Multi-domain]  Cd Length: 406  Bit Score: 63.06  E-value: 1.15e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730   9 RTSNKAMTFFVCFLAALaglLFGLDIGVIAGALPFITDEFQISAHTQEWVVSSMMFGAAVGAVGSGWLSFKLGRKKSLMI 88
Cdd:PRK11551   9 SSSRLALTIGLCFLVAL---LEGLDLQSAGVAAPRMAQEFGLDVAQMGWAFSAGILGLLPGALLGGRLADRIGRKRILIV 85
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  89 GAILFVAGSLFSAAAPNVEVLIISRVLLGLAVGVASYTAPLYLSEIAPEKIRGSMIS-MY 147
Cdd:PRK11551  86 SVALFGLFSLATAQAWDFPSLLVARLLTGVGLGGALPNLIALTSEAVGPRLRGTAVSlMY 145
MFS_CitA cd17368
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton ...
68-394 1.29e-10

Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton symporter, also called citrate carrier protein or citrate transporter or citrate utilization protein A (CitA), is a proton symporter that functions in the uptake of citrate across the boundary membrane. It allows the utilization of citrate as a sole source of carbon and energy. In Klebsiella pneumoniae, the gene encoding this protein is called citH, instead of citA, which is the case for Escherichia coli and other organisms. CitA belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340926 [Multi-domain]  Cd Length: 407  Bit Score: 63.16  E-value: 1.29e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  68 VGAVGSGWLSFKLGRKKSLMIGAILFVAGSLFSAAAPNVE--------VLIISRVLLGLAVGVASYTAPLYLSEIAPEKI 139
Cdd:cd17368   55 IGAIVLGAYADRIGRKPAMTLTLAIMALGTLLIALAPTYAtigiaaplLVLLARLLQGFAAGGEVGGVTAYLVEAAPPGR 134
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 140 RG---SMISMYQLMITI--GILGAYLSDT-AFSYSGAWRWMLgviiipaiLLLIGVFFLPdsprwfaakrrfhdaerVLL 213
Cdd:cd17368  135 RGfytSWQSASQQVAIVagALVGYLLSLTlTAEALAEWGWRI--------PFFIGLLIIP-----------------LGL 189
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 214 RLRDTSAEAKNELEEIRESLkvKQSGWALFKENsnfRRAVFLGVLLQIMQQFTgMNVIMYYAPKIFELAGYTNTTEQMWG 293
Cdd:cd17368  190 WLRRSLEETEAFLERKARPT--RRELFALLANN---RRIILLGMLLVAGSTVT-FYFTTVYTPTYAKTVLGLSARDSFLV 263
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 294 TVIVGLTNVLATFIAIGLVDRWGRKPTL---TLGFLVMAVgmgvlgTMMHMGIHSPTAQYFaVAMLLMFIIGFAMSAGPL 370
Cdd:cd17368  264 TLLAGVANFIWAPLGGALSDRIGRRPVLlviTLAALVTLY------PVFAWLTAAPSFGRL-LLVLLVLSFFFGMYGGAM 336
                        330       340
                 ....*....|....*....|....*.
gi 505384730 371 IwVLCSEIQP--LKGRDFGITCSTAT 394
Cdd:cd17368  337 V-VALVELFPvrVRSTGFSLVYALAV 361
MFS_SV2 cd17363
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic ...
17-237 2.73e-10

Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. The SV2 family belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340921 [Multi-domain]  Cd Length: 474  Bit Score: 62.12  E-value: 2.73e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  17 FFVCFLAALAGllfGLDIGVIAGALPFITDEFQISAHTQEWVVSSMMFGAAVGAVGSGWLSFKLGRKKSLMIGAILFVAG 96
Cdd:cd17363    1 FFVLGLALMAD---GVEVFVVGFVLPSAEKDMCLSNSNKGMLGLIVYLGMMVGAFVWGGLADKLGRKQCLLIALSVNGVF 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  97 SLFSAAAPNVEVLIISRVLLGLAVGVASYTAPLYLSEIAPEKIRGSMISMYQLMITIGilGAYLSDTA----------FS 166
Cdd:cd17363   78 AFLSSFVQGYGFFLFCRLLSGIGIGGSIPIVFSYFAEFLAREKRGEHLSWLCMFWMIG--GLYASAMAwaiiphygwgFS 155
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 505384730 167 YSGA-----WRWMLGVIIIPAILLLIGVFFLPDSPRWFAAKRRFHDAERVLLRLRDTSAEAKNELEEIRESLKVKQ 237
Cdd:cd17363  156 MGTAyqfhsWRVFVIVCALPSVASVVALTFMPESPRFLLEVGKHDEAWMILKQVHDTNMRAKGHPERVFTVSHIKR 231
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
16-437 2.78e-10

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 61.82  E-value: 2.78e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  16 TFFVCFLAALAGLLFGLDIGVIAGALPFITDEFQISAHTQEWVVSSMMFGAAVGAVGSGWLSFKLGRKKSLMIGAILFVA 95
Cdd:cd17319    1 RWRIIPLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  96 GSLFSAAAPNVEVLIISRVLLGLAVGVASYTAPLYLSEIAPEKIRGSMISMYQLMITIG-ILGAYLSDTAFSYSGaWRWM 174
Cdd:cd17319   81 FTALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGaAIGPPLSGWLLLLFG-WRWA 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 175 LGViiipailllIGVFFLPDSPRWFAAKRRFhdaervllrlrdtsaeakneleeireslkvkqsgWALFkensnfrrAVF 254
Cdd:cd17319  160 FII---------EGLLGLLLAVLWWFYLRQV----------------------------------WGLA--------LGY 188
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 255 LGVLlqimqqfTGMNVIMYYAPKIFELAGYTNTTEQMWGTVIVGLTNVLATFIAIGLVDR---WGRKPTLTLGFLVMAVG 331
Cdd:cd17319  189 FGIN-------YALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRllrGARRLVIIIGLLLAAVG 261
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 332 MGVLGTMMHMgihsptaqyfAVAMLLMFIIGFAMSAG-PLIWVLCSEIQPLK--GRDFGITCSTAT--NWIANMIVGAtf 406
Cdd:cd17319  262 LLLAYLTTSP----------VVAVILLSLAGFGIGAAsPVFWSLPADLLPGEaaATAGGLINSGGNlgGFVAPLLIGY-- 329
                        410       420       430
                 ....*....|....*....|....*....|.
gi 505384730 407 ltMLNTLGNANTFWVYAGLNLFFIVLTIWLV 437
Cdd:cd17319  330 --LVDATGSYTAAFLFLAAVALLAALLVLLL 358
MFS_KgtP cd17367
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ...
59-441 3.62e-10

Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340925 [Multi-domain]  Cd Length: 407  Bit Score: 61.54  E-value: 3.62e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  59 VSSMMFGAAVGAVG----------SGWLSFKLGRKKSLMIGAILFVAGSLFSAAAPNVE--------VLIISRVLLGLAV 120
Cdd:cd17367   36 TVALLSTAAVFAVGflmrpiggwlFGRLADRIGRRAALTLSVSLMAAGSLVIAVTPTYAtigiwapiILLLARLLQGLSV 115
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 121 GVASYTAPLYLSEIAPEKIRGSMISMYQLMITIGILGAYLSDTAFSY--------SGAWR--WMLGviiipaillliGVF 190
Cdd:cd17367  116 GGEYGTSATYLSEVAPPGRRGFYSSFQYVTLIGGQLLALGVLLVLQHtlgedqmaAWGWRipFLLG-----------GVL 184
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 191 FLpdsprwfaakrrfhdaerVLLRLRDTSAEAKnELEEIRESLKVKQSGWALFKensNFRRAVFLGVLLQimqqfTGMNV 270
Cdd:cd17367  185 AV------------------VVLWLRRGLEETE-SFEAIAESNEASAGTLRELR---RHPRELLLVVGLT-----AGGTL 237
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 271 IMY----YAPKIFELAGYTNTTEQMWGTVIVGLTNVLATFIAIGLVDRWGRKPTLtlgfLVMAVGMGVLGTMMHMGIHSP 346
Cdd:cd17367  238 AFYtwttYLQKFLVNTAGFSKGDATWITTAALLVFMLLQPLGGRLSDRIGRRPLL----LFFGIGGTLATVPLLSALDHT 313
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 347 TAQYFAVAMLL--MFIIGFAMSAGPliwVLCSEIQPLKGRDFGITCSTAtnwIANMIVGAT---FLTMLNTLGNANTFWV 421
Cdd:cd17367  314 DSPYTAFALVLvgLVFLSGYTSINA---VVKAELFPTHVRALGVGLPYA---LAVAIFGGTapyVALWLKSIGHEWVFFW 387
                        410       420
                 ....*....|....*....|
gi 505384730 422 YAGLNLFFIVLTIWLVPETK 441
Cdd:cd17367  388 YVAGLIAISLVVYLRMPETR 407
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
21-164 7.72e-10

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 60.28  E-value: 7.72e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  21 FLAALAGLLFGLDIGVIAGALP-FITDEFQISAHTQEWVVSSMMFGAAVGAVGSGWLSFKLGRKKSLMIGAILFVAGSLF 99
Cdd:cd17325  202 LALFLAIFVLAFAFGALEPFLPlYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLL 281
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 100 SAAAPNVEVLIISRVLLGLAVGVASYTAPLYLSEIAPEKIRGSMISMYQLMITIG-----ILGAYLSDTA 164
Cdd:cd17325  282 LPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGmvlgpLLGGFLYDAF 351
MFS_SV2C cd17440
Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; ...
17-237 3.33e-09

Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2C exhibits enriched expression in several basal ganglia nuclei, and has been found to be involved in normal operation of the basal ganglia network and could be also be involved in system adaptation in basal ganglia pathological conditions. SV2C belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340998 [Multi-domain]  Cd Length: 479  Bit Score: 58.77  E-value: 3.33e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  17 FFVCFLAALAGllfGLDIGVIAGALPFITDEFQISAHTQEWVVSSMMFGAAVGAVGSGWLSFKLGRKKSLMIGAILFVAG 96
Cdd:cd17440    1 FFVLGMALMAD---GVEVFVVGFVLPSAETDMCIPNSGSGWLGSIVYLGMMVGAFFWGGLADKVGRRQSLLICMSVNGFF 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  97 SLFSAAAPNVEVLIISRVLLGLAVGVASYTAPLYLSEIAPEKIRGSMISMYQLMITIGilGAYLSDTA----------FS 166
Cdd:cd17440   78 AFLSSFVQGYGLFLFCRLLSGFGIGGAVPTVFSYFAEVLAREKRGEHLSWLCMFWMIG--GIYASAMAwaiiphygwsFS 155
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 505384730 167 YSGA-----WRWMLGVIIIPAILLLIGVFFLPDSPRWFAAKRRFHDAERVLLRLRDTSAEAKNELEEIRESLKVKQ 237
Cdd:cd17440  156 MGSAyqfhsWRVFVIVCALPCVSSVVALTFMPESPRFLLEVGKHDEAWMILKQIHDTNMRARGQPEKVFTVNRIKK 231
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
21-171 9.05e-09

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 57.20  E-value: 9.05e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  21 FLAALAGLLFGLDIGVIAGALPFITD-EFQISAHTQEWVVSSMMFGAAVGAVGSG-WLSFKLGRKKSLMIGAILFVAGSL 98
Cdd:cd17474  201 LTFLVSAFLYFFLYFAFLTYLPFLLElLYGISPIIIGLLFAGWSVLLALGSLFVGrLLKKRFGARRILVIGLLLYALSLL 280
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  99 FSAAAPNVEVLIISRVLLGLAVGVASYTAPLYLSEIAPEKIRGSMISMYQLM---------ITIGILGAYLSDTAFSYSG 169
Cdd:cd17474  281 LLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVrflgqavgpLLFGLLLEIFGLSAPFLVG 360

                 ..
gi 505384730 170 AW 171
Cdd:cd17474  361 AA 362
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
21-160 9.12e-09

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 57.24  E-value: 9.12e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  21 FLAALAGLLFGLDIGVIAGALPFITDEFQISAHTQEWVVSSMMFGAAVGAVGSGWLSFKLGRKKSLMIGAILFVAGSLFS 100
Cdd:cd06173  212 LLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVL 291
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 101 AAAPNVEVLIISRVLLGLAVGVASYTAPLYLSEIAPEKIRGSMISMYQLMITIGILGAYL 160
Cdd:cd06173  292 GLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGAL 351
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
25-366 1.02e-08

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 56.81  E-value: 1.02e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  25 LAGLLFGLDIGVIAGALPFITDEFQ-ISAHTQEWVVSSMMFGAAVGAVGSGWLSFKLGRKKSLMIGAILFVAGSLFSAAA 103
Cdd:cd17473    6 LASTLTVMAGAAIAPALPAIAQHFVpNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFL 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 104 PNVEVLIISRVLLGLAVGVASYTAPLYLSEIAPEKIRGSMISMYQLMITIG-----ILGAYLSDTafsysgAWRWMLGVI 178
Cdd:cd17473   86 DSLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGgvvflLLGGALAEI------GWRAPFLVY 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 179 IIPAILLLIGVFFLPDSPrwfaakrrfhdaervllrlRDTSAEAKNELEEIRESLKVKQSGWALfkensnfrrAVFLGVL 258
Cdd:cd17473  160 LLALPVLILVLLFLPEPA-------------------RKSKSAASPGAATAAALPWKRVLPIYF---------LAFLAML 211
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 259 LqimqqftgMNVIMYYAPKIFELAGYTNTTEQMWGTVIVGLTNVLATFIAIGLVDRWGRKPTLTLGFLVMAVGMGVLGtm 338
Cdd:cd17473  212 L--------FYVIPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLA-- 281
                        330       340
                 ....*....|....*....|....*...
gi 505384730 339 mhmgihspTAQYFAVAMLLMFIIGFAMS 366
Cdd:cd17473  282 --------LASGLWVVLLGAILAGLGFG 301
efflux_Bcr_CflA TIGR00710
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ...
16-124 1.99e-08

drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.


Pssm-ID: 273229 [Multi-domain]  Cd Length: 385  Bit Score: 56.24  E-value: 1.99e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730   16 TFFVCFLAALAGLLFGLDIGVIAGALPFITDEFQISAHTQEWVVSSMMFGAAVGAVGSGWLSFKLGRKKSLMIGAILFVA 95
Cdd:TIGR00710   3 AKAFALLLGCLSILGPLGIDMYLPAFPEIAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFAL 82
                          90       100
                  ....*....|....*....|....*....
gi 505384730   96 GSLFSAAAPNVEVLIISRVLLGLAVGVAS 124
Cdd:TIGR00710  83 SSLGLALSNNIETLLVLRFVQAFGASAGS 111
MFS_ShiA_like cd17369
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ...
68-370 3.39e-08

Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340927 [Multi-domain]  Cd Length: 408  Bit Score: 55.61  E-value: 3.39e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  68 VGAVGSGWLSFKLGRKKSLMI-----GAILFVAGSLFSAA-----APnvEVLIISRVLLGLAVGVASYTAPLYLSEIAPE 137
Cdd:cd17369   59 LGGVVFGHFGDRIGRKKTLVLtlllmGIATFLIGLLPTYAqigilAP--ILLVLLRLLQGLALGGEWGGAVLMAVEHAPP 136
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 138 KIRGSMISMYQLMITIG---------ILGAYLSDTAFSysgAWRW---------MLGViiipaillliGVFflpdsprwf 199
Cdd:cd17369  137 KRRGFYGSFPQLGAPVGlllatgvflLLSALLSDEAFL---SWGWripfllsavLVAV----------GLY--------- 194
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 200 aakrrfhdaerVLLRLRDTSaeaknELEEIRESLKVKQSG-WALFKENsnfRRAVFLGVLLQIMQQ--FTGMNV-IMYYA 275
Cdd:cd17369  195 -----------IRLRLEETP-----VFRRAKEAGQVVRAPlVEVLRRH---WRALLLAIGLRLAENvlFYLFTTfALSYA 255
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 276 PKIFELAGYTNTTEQMWGTVIVGLTNVLATFIAiglvDRWGRKPTltlgFLVMAVGMGVLGTMMHMGIHSPTAQYFAVAM 355
Cdd:cd17369  256 TQTLGVDRSTVLLAVLIASVVAAITIPLFGWLS----DRVGRRPV----YLAGALLAALFAFPFFWLLDTGSTWLIVLAA 327
                        330
                 ....*....|....*
gi 505384730 356 LLMFIIGFAMSAGPL 370
Cdd:cd17369  328 VVVLGVLHGMMYGPQ 342
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
25-171 4.12e-08

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 54.87  E-value: 4.12e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  25 LAGLLFGLDIGVIAGALPFITDEFQISAHTQEWVVSSMMFGAAVGAVGSGWLSFKLGRKKSLMIGAILFVAGSLFSAAAP 104
Cdd:cd17477    3 LSVALLGLGSGLLLPLLSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTD 82
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 505384730 105 NVEVLIISRVLLGLAVGVASYTAPLYLSEIAPEKIRGSMISMYQLMITIGILGAYLSDTAFSYSGAW 171
Cdd:cd17477   83 SPWVWFLLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLLLALVGTAGAL 149
MFS_SV2B cd17438
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; ...
17-229 5.66e-08

Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2B is a key modulator of amyloid toxicity at the synaptic site and also has an essential role in the formation and maintenance of the glomerular capillary wall. SV2B belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340996 [Multi-domain]  Cd Length: 477  Bit Score: 54.93  E-value: 5.66e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  17 FFVCFLAALAGllfGLDIGVIAGALPFITDEFQISAHTQEWVVSSMMFGAAVGAVGSGWLSFKLGRKKSLMIGAILFVAG 96
Cdd:cd17438    1 FFVLGLALMAD---GVEVFVVGFVLPSAEKDMCLSSSNKGMLGLIVYLGMMAGAFIWGGLADKLGRKRCLIISLAINASF 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  97 SLFSAAAPNVEVLIISRVLLGLAVGVASYTAPLYLSEIAPEKIRGSMISMYQLMITIGilGAYLSDTAFS---------- 166
Cdd:cd17438   78 AFLSSFVQGYGAFLFCRLISGFGIGGSLPIVFAYFSEFLAREKRGEHLSWLCMFWMIG--GLYASAMAWSiiphygwgfs 155
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 505384730 167 -----YSGAWRWMLGVIIIPAILLLIGVFFLPDSPRWFAAKRRFHDAERVLLRLRDTSAEAKNELEEI 229
Cdd:cd17438  156 mgtnyHFHSWRVFVIICALPCIASIIALKFMPESPRFLLEMGKHDEAWMILKNIHDTNMRAKGTPEKV 223
2_A_01_02 TIGR00880
Multidrug resistance protein;
73-173 1.18e-07

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 50.73  E-value: 1.18e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730   73 SGWLSFKLGRKKSLMIGAILFVAGSLFSAAAPNVEVLIISRVLLGLAVGVASYTAPLYLSEIAPEKIRGSMISMYQLMIT 152
Cdd:TIGR00880  18 SGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIYPPEERGVALGLMSAGIA 97
                          90       100
                  ....*....|....*....|.
gi 505384730  153 IGILGAYLSDTAFSYSGAWRW 173
Cdd:TIGR00880  98 LGPLLGPPLGGVLAQFLGWRA 118
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
21-154 2.71e-07

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 52.60  E-value: 2.71e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  21 FLAALAGLLFGLDIGVIAGALP-FITDEFQISAHTQEWVVSSMMFGAAVGAVGSGWLSFKLGRKKSLMIGAILFVAGSL- 98
Cdd:COG2211  231 LLLLLAYLLFFLALALVAALLLyYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLl 310
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 505384730  99 -FSAAAPNVEVLIISRVLLGLAVGVASYTAPLYLSEIAP-------EKIRGSMISMYQLMITIG 154
Cdd:COG2211  311 lFFLGPGNLWLLLVLAALAGIGLGAILVLPWAMLADVVDydewktgRRREGLYFGIFTFAIKLG 374
PRK03893 PRK03893
putative sialic acid transporter; Provisional
21-174 5.51e-07

putative sialic acid transporter; Provisional


Pssm-ID: 179668 [Multi-domain]  Cd Length: 496  Bit Score: 52.01  E-value: 5.51e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  21 FLAALAG-LLFGLDIGVIAGALPFITDEFQISAHTQEWVVS----SMMFGA-AVGAVGSgwlsfKLGRKKSLMIGAILFV 94
Cdd:PRK03893  22 FSAAWLGyLLDGFDFVLITLVLTEVQGEFGLTTVQAASLISaafiSRWFGGlLLGAMGD-----RYGRRLAMVISIVLFS 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  95 AGSLFSAAAPNVEVLIISRVLLGLAVGVASYTAPLYLSEIAPEKIR----GSMISMYQlmitigiLGAYLSDTAFSY--- 167
Cdd:PRK03893  97 VGTLACGFAPGYWTLFIARLVIGMGMAGEYGSSATYVIESWPKHLRnkasGFLISGFS-------IGAVVAAQVYSLvvp 169

                 ....*..
gi 505384730 168 SGAWRWM 174
Cdd:PRK03893 170 VWGWRAL 176
2A0104 TIGR00881
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ...
40-177 5.69e-07

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273319 [Multi-domain]  Cd Length: 379  Bit Score: 51.61  E-value: 5.69e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730   40 ALPFITDEFQISAHTQEWVVSSMMFGAAVGAVGSGWLSFKLGRKKSLMIGAILFVAGSLFSAAAPNVEVLIISRVLLGLA 119
Cdd:TIGR00881  17 AMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWALNGIF 96
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 505384730  120 VGVASYTAPLYLSEIAPEKIRGSMISMYQLMITI-GILGAYLSDTAFSYSGAWRWMLGV 177
Cdd:TIGR00881  97 QGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVgGGLLPPLVLFGIAELYSWHWVFIV 155
MFS_FEN2_like cd17327
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ...
50-406 6.23e-07

Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340885 [Multi-domain]  Cd Length: 406  Bit Score: 51.48  E-value: 6.23e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  50 ISAHTQEWVVSSMMFGAAVGAVGSGWLSFKLGRKKSLMIGAILFVAGSLFSAAAPNVEVLIISRVLLGLAVGVASYTAPL 129
Cdd:cd17327   38 LVGNQYNWGNTVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGLLTLLTAAVKNFGGLIALRFFLGLFESGVFPGFIL 117
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 130 YLSEIAPEKIRGSMISMYQLMITIG-ILGAYLSDTAFSYSGA-----WRWM-LGVIIIPAILLLIGVFFLPDSP--RWFa 200
Cdd:cd17327  118 YLGMWYKREEQAKRIAFFYAAAGLGsIFGGLLAYGVFKILGVgglagWRWLfIIEGLITIIIGLVIFFWLPDNPskAWF- 196
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 201 akrrFHDAERVLLRLRdtsaeakneLEEIRESLKVKQSGWALFKEnsNFRR-AVFLGVLLQIMQQFTgMNVIMYYAPKIF 279
Cdd:cd17327  197 ----LTEEEKELAVER---------LRANQTGKGDQKFKWKQIKE--AFKDpRTWLLFLFFFCSQIT-NNGISNFLPLIL 260
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 280 ELAGYTNTTEQMWgTVIVGLTNVLATFIAIGLVDRWGRKPTLTLGFLVMA-VGMGVLGtmmhmGIHSPTAQYFAVAMLLM 358
Cdd:cd17327  261 KSLGFYSLQTNLL-SVPIGALGAVSLLIAALLSDRFKKRGLFAIFACVLAlVGSIILL-----AAPNPPGAYFAAYILGG 334
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*...
gi 505384730 359 fiiGFAMSAGPLIWVLCSEIQPLKGRDFGITCSTATNWIANMIVGATF 406
Cdd:cd17327  335 ---GSYAGFPILLSWISSNCAGYTKRATVLAIMLIFYNVGNIVAPQIF 379
MFS_OFA_like cd17353
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ...
21-436 7.20e-07

Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340911 [Multi-domain]  Cd Length: 389  Bit Score: 51.07  E-value: 7.20e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  21 FLAALAGLLFGLDIGVIAG---ALPFITDEFQISAHTQEWVVSSMMFGAAVGAVGSGWLSFKLGRKKSLMIGAILFVAGS 97
Cdd:cd17353    3 WLVLLGAVLMHLILGYQYAwsvFNPPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGLGF 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  98 LFSAAAPNVEVLIISR-VLLGLAVGVAsYTAPLYLS-EIAPEKiRGsMISMyqlMITIG-----ILGAYLSDTAFSYSGA 170
Cdd:cd17353   83 ILSAFAISLPLLFLGYgVLGGIGAGIG-YITPVSTAvKWFPDK-RG-LATG---IVIAGfglgsLIFSPLIAYLINTVGV 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 171 WRWMLGVIIIPAILLLIGVFFLPDSPRWFAAKRRFHDAERVLLRLRDTSAeakneleeiRESLKVKQsGWALFKensnfr 250
Cdd:cd17353  157 PTTFLILGIIFLIIIVIGAFLIRDPPKGWVPPGVDPLANNAENSPRDYTP---------REMLRTPT-FWLLWL------ 220
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 251 rAVFLGVllqimqqFTGMNVIMYYAPKIFELAGYTNTTEQMWGTVIvGLTNVLATFIAIGLVDRWGRKPTLTLGFLVMAV 330
Cdd:cd17353  221 -MFFLNA-------TAGLMLIGQAKPIGQEFAGLDAGIAALAVSIL-SIFNGGGRPFWGWLSDKIGRKNTLSIAFLIQGV 291
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 331 GMGVLgtmmhmgihSPTAQYFAVAMLLMFIIGFAMSAG-PLIWVLCSEIQPLK--GRDFGIT-CSTAtnwIANMIVGATF 406
Cdd:cd17353  292 AMFLL---------PFIGSVAVLFVLGVALIGFCYGGGfALFPALTADFFGTKnaGTNYGLLyTAKG---VGGLIGPIIA 359
                        410       420       430
                 ....*....|....*....|....*....|
gi 505384730 407 LTMLNTLGNANTFWVYAGLNLFFIVLTIWL 436
Cdd:cd17353  360 AYVLYTGGYNAAFIIAAALSLVALALALLL 389
MFS_SLC17A9_like cd17380
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ...
40-123 1.04e-06

Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340938 [Multi-domain]  Cd Length: 361  Bit Score: 50.63  E-value: 1.04e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  40 ALPFITDEFQISAHTQEWVVSSMMFGAAVGAVGSGWLSFKLGRKKSLMIGAILFVAGSLFS--AAAPNVEVLIISRVLLG 117
Cdd:cd17380   21 AIVPMAKEFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLLTplLAYSSLPLLILSRILLG 100

                 ....*.
gi 505384730 118 LAVGVA 123
Cdd:cd17380  101 LGEGVH 106
MFS_SV2A cd17439
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; ...
21-237 1.30e-06

Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. It is unclear how SV2A is involved in correct SV function, but it has been suggested to either act as a transporter or a regulator of exocytosis by mediating Ca2+ dynamics. SV2A has been identified as the molecular target of the antiepileptic drug levetiracetam (LEV). Its expression is decreased in patients with epilepsy and in epileptic animal models. SV2A belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340997 [Multi-domain]  Cd Length: 478  Bit Score: 50.80  E-value: 1.30e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  21 FLAALAGLLFGLDIGVIAGALPFITDEFQISAHTQEWVVSSMMFGAAVGAVGSGWLSFKLGRKKSLMIGAILFVAGSLFS 100
Cdd:cd17439    2 FVLGLALMADGVEVFVVGFVLPSAEKDMCLSDSNKGMLGLIVYLGMMVGAFLWGGLADRIGRRQCLLISLSVNSVFAFFS 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 101 AAAPNVEVLIISRVLLGLAVGVASYTAPLYLSEIAPEKIRGSMISMYQLMITIGilGAYLSDTA----------FSYSGA 170
Cdd:cd17439   82 SFVQGYGTFLFCRLLSGVGIGGSIPIVFSYFSEFLAQEKRGEHLSWLCMFWMIG--GIYASAMAwaiiphygwsFQMGSA 159
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 505384730 171 -----WRWMLGVIIIPAILLLIGVFFLPDSPRWFAAKRRFHDAERVLLRLRDTSAEAKNELEEIRESLKVKQ 237
Cdd:cd17439  160 yqfhsWRVFVLVCAFPSVFAIGALTTMPESPRFFLENGKHDEAWMVLKQVHDTNMRAKGHPERVFSVTHIKR 231
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
40-374 2.00e-06

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 49.90  E-value: 2.00e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  40 ALPFITDEFQISAhtqeWVVSSMMFGA----AVGAVGSGWLS----FKLGRKKS-LMIGAILFVAGSLFSAAAPNVE--- 107
Cdd:COG2211   33 LLYFYTDVLGLSA----ALVGLILLVArlwdAITDPLIGALSdrtrTRWGRRRPwILIGAIPLALSFVLLFTAPDLSptg 108
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 108 ---VLIISRVLLGLAVGVAS--YTAplYLSEIAPE-KIRGSMISMYQLMITIG-ILGAYLSDTAFSYSG-----AWRWML 175
Cdd:COG2211  109 kliYALVTYLLLGLAYTLVNipYSA--LGAELTPDyEERTRLSSWRFAFAGLGgLLASVLPPPLVAAFGgdaalGYRLTA 186
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 176 GVIIIPAILLLIGVFFLpdsprwfaAKRRFHDAErvllrlrdtsaeakneleeirESLKVKQSGWALFKeNSNFRRAVFL 255
Cdd:COG2211  187 LIFAVLGLLAFLLTFFG--------TKERPVPEE---------------------EKVSLKESLKALLK-NRPFLLLLLA 236
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 256 GVLLQIMQQFTGMnVIMYYAPKIFELagytNTTEQMWGTVIVGLTNVLATFIAIGLVDRWGRKPTLTLGFLVMAVGMGVL 335
Cdd:COG2211  237 YLLFFLALALVAA-LLLYYFKYVLGL----SAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLL 311
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|
gi 505384730 336 GTMmhmgihspTAQYFAVAMLLMFIIGFAMSA-GPLIWVL 374
Cdd:COG2211  312 FFL--------GPGNLWLLLVLAALAGIGLGAiLVLPWAM 343
MFS_FucP_MFSD4_like cd17333
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ...
28-173 2.26e-06

Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340891 [Multi-domain]  Cd Length: 372  Bit Score: 49.63  E-value: 2.26e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  28 LLFGLDIGVIAGALPFITDEFQISAHTQEWVVSSMMFGAAVGAVGSGWLSFKLGRKKSLMIGAILFVAGSLFSAAAPNVE 107
Cdd:cd17333    6 FSNGLTDALLGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIY 85
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 505384730 108 VLIISRVLLGLAVGVASYTAPLYLSEIAPEKIRGSMISMYQLMITIGILGAYLSDTAFSYSGAWRW 173
Cdd:cd17333   86 LFVVLMFLAGLGAGILDTGANTFVGALFEESSATRLNVLHGFFGLGALIGPLIATSLLTSELSWSW 151
MFS_1 pfam07690
Major Facilitator Superfamily;
21-156 2.85e-06

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 49.34  E-value: 2.85e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730   21 FLAALAGLLFGLDIGVIAGALPFITDEFQISAHTQEWVVSSMMFGAAVGAVGSGWLSFKLGRKKSL---MIGAILFVAGS 97
Cdd:pfam07690 203 LWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLllaLLLLILAALGL 282
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 505384730   98 LFSAAAPNVEVLIISRVLLGLAVGVASYTAPLYLSEIAPEKIRGSMISMYQLMITIGIL 156
Cdd:pfam07690 283 LLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGA 341
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
43-437 6.21e-06

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 48.38  E-value: 6.21e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  43 FITDEFQISAHTQEWVVSSMMFGAAVGAVGSGWLSFKLGRKKSLMIGAILFVAGSLFSAAAPNVEVLIISRVLLGLAVGV 122
Cdd:cd17329   25 YLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGL 104
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 123 ASYTAPLYLSEIAPEKIRGSMISMYQLMITIGI-LGAYLSDTAFSYSGAWRWMLGviiipailllIGVFFLpdsprwFAA 201
Cdd:cd17329  105 FEPASEAMIADVTTPENRTRAFSLLYWAINLGVaIGPLLGGLLLLYSFRLLFLAA----------AVLFLL------AAL 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 202 krrfhdaerVLLRL--RDTSAEAKNELEEIRESLKVKqsgwalfkensnFRRAVFLGVLLQIMQQFTGMNVIMYYAPKIF 279
Cdd:cd17329  169 ---------VLLFLlpETRPKRRAAEKTEILRGYKIV------------LRDRAFLLFLLASFLISLIYFQLESTLPVYV 227
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 280 ELAGYTNTTEQMWGTVIVGLTNVLATFIAIGLVDRWGRKPTLTLGFLVMAVGMGVLGtmmhmgihspTAQYFAVAMLLMF 359
Cdd:cd17329  228 VEILGLGESLLGLLLALNALLIVLLQFPVARLVERFRLRKILMIGILLFAIGFAVLA----------FANTLAVLILAMI 297
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 360 IIGFA-MSAGPLIWVLCSEIQP--LKGRDFGI--TCSTATNWIANMIVGAtfltMLNTLGNANTFWVYAGLNLFFIVLTI 434
Cdd:cd17329  298 VLTLGeMLVFPAVQTLVAALAPpdKRGSYMGFyaLAWGLGRAIGPLVGGL----LLDLLGPGLPWLILAALGLIAAALLL 373

                 ...
gi 505384730 435 WLV 437
Cdd:cd17329  374 GLQ 376
MFS_CsbX cd17337
CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed ...
66-436 1.12e-05

CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed of Bacillus subtilis CsbX protein (also named alpha-ketoglutarate permease), Klebsiella pneumoniae D-arabinitol transporter (DalT), and similar proteins. The csbX gene is a sigmaB-controlled gene that is expressed during the stationary phase of cell growth. DalT is a pentose-specific ion symporter for D-arabinitol uptake. Most members of this family remain uncharacterized. The CsbX family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340895 [Multi-domain]  Cd Length: 388  Bit Score: 47.50  E-value: 1.12e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  66 AAVGAVGSGWLSFKLGRKKSLMIGAILFVAGSL----FSAAAPNVEVLIISRVLLGLAVGVASYTAPLYLSEIAPEKIRG 141
Cdd:cd17337   45 VAIASWLSGVLAELFGPRRVMLIGLIIWLVFEVlflaFGLPSHNYPLMLLTYGLRGFGYPLFAYSFLVWITYRTPAERLG 124
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 142 SMISMYQLMITIG--ILGAYLSDTAFSYSGAwrwmLGVIIIPAILLLIGVFFlpdsprwfaakrrfhdaerVLLRLRDTS 219
Cdd:cd17337  125 SAVGWFWFAFTGGlpVLGSYLASFTIPVIGE----IGTLWLSLVFVALGGLI-------------------ALFLVRDRT 181
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 220 AEAKNELEEiRESLKVKQSGWALFKENsnfrRAVFLGVLLQIMQQFT--GMNVIM--YYAPKIfelaGYTnTTE--QMWG 293
Cdd:cd17337  182 GEQPLANPS-EEPLKELLSGITILFRN----PKIAIGGIVRIINTLSqfGFPVFMplYFTDTG----GFS-TSQwlQIWG 251
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 294 tvIVGLTNVLATFIAIGLVDRWGRKPTLTL-GFLVMAVGMGVLGTMMHMGIHSptaqyFAVAMLLMFIIGFAMSA-GPLI 371
Cdd:cd17337  252 --IIFLVNIFFNLIFGILGDKIGWRRTVRWfGGVGCAISTLLFYYVPQLFGHN-----YWAALIAAILFGIGLAGfVPLS 324
                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 505384730 372 WVLCSEIQPLKGRDFGITC--STATNWIANMIVGAtfltMLNTLGNANTFWVYAGLNLFFIVLTIWL 436
Cdd:cd17337  325 ALMPSLAPEHKGAAMSILNlgAGLSNFVGPAIVTL----FLGSFGAGGVVWIFAGLYLLSAVLTLFL 387
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
247-452 1.54e-05

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 46.89  E-value: 1.54e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 247 SNFRRAVFLGVLLQIMQQFTGMNVIMYYAPKIFELAGYTNTTEQmWGTVIVGLTNVLATFIAIGLVDRWGRKPTLTLGFL 326
Cdd:COG2814    5 PRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAG-LVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLL 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 327 VMAVGMGVLGTmmhmgihsptAQYFAVAMLLMFIIGFAMSAG-PLIWVLCSEIQPLKGRDFGITCSTATNWIANMIVGAT 405
Cdd:COG2814   84 LFALGSLLCAL----------APSLWLLLAARFLQGLGAGALfPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLL 153
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 505384730 406 FLTMLNTLGNANTFWVYAGLNLFFIVLTIWLVPETKHVSLEHIERNL 452
Cdd:COG2814  154 GGLLADLFGWRWVFLVNAVLALLALLLLLRLLPESRPAARARLRGSL 200
PRK11102 PRK11102
Bcr/CflA family multidrug efflux MFS transporter;
40-160 1.78e-05

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182964 [Multi-domain]  Cd Length: 377  Bit Score: 46.83  E-value: 1.78e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  40 ALPFITDEFQISAHTQEWVVSSMMFGAAVGAVGSGWLSFKLGRKKSLMIGAILFVAGSLFSAAAPNVEVLIISRVLLGLA 119
Cdd:PRK11102  13 ALPVIAADFGVSAGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFLHGLA 92
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 505384730 120 VGVASYTAPLYLSEIAPEKIRGSMISMYQLMITIG-----ILGAYL 160
Cdd:PRK11102  93 AAAASVVINALMRDMFPKEEFSRMMSFVTLVMTIApllapIIGGWL 138
MFS_SVOP cd17441
Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic ...
47-198 1.82e-05

Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein (SVOP) is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. This SVOP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340999 [Multi-domain]  Cd Length: 372  Bit Score: 46.73  E-value: 1.82e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  47 EFQISAHTQEWVVSSMMFGAAVGAVGSGWLSFKLGRKKSLMIGAILFVAGSLFSAAAPNVEVLIISRVLLGLAVGVASYT 126
Cdd:cd17441   28 EWRLPSWQVALLTSVVFIGMMLSSSLWGNISDQYGRKTGLKISVLWTLYYGILSAFAPIYSWILVLRGLVGFGIGGVPQS 107
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 505384730 127 APLYlSEIAPEKIRGSMISMYQLMITIG-ILGAYLSDTAFSYSGaWRWMLGVIIIPAILLLIGVFFLPDSPRW 198
Cdd:cd17441  108 VTLY-AEFLPMKSRAKCILLIEVFWALGtVFEVLLAVFVMPTLG-WRWLLILSALPLLIFAVLCFWLPESARY 178
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
57-161 3.63e-05

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 45.65  E-value: 3.63e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  57 WVVSSMMFGAAVGAVGSGWLSFKLGRKKSLMIGAILFVAGSLFSAAAPNVEVLIISRVLLGLAVGVASyTAPLYLSEIAP 136
Cdd:cd17330   38 LLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLARFLDGLTGGNVS-VAQAYIADITD 116
                         90       100       110
                 ....*....|....*....|....*....|
gi 505384730 137 EKIRGSMISMYQLMITIG-----ILGAYLS 161
Cdd:cd17330  117 EEERAKAFGIISAAFGLGfilgpALGGFLS 146
TRI12 pfam06609
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific ...
10-175 4.15e-05

Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific trichothecene efflux pump proteins. Many of the genes involved in trichothecene toxin biosynthesis in Fusarium sporotrichioides are present within a gene cluster.It has been suggested that TRI12 may play a role in F. sporotrichioides self-protection against trichothecenes.


Pssm-ID: 115279 [Multi-domain]  Cd Length: 598  Bit Score: 45.81  E-value: 4.15e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730   10 TSNKAMTFFVCFLAALAGLLFGLDIGviAGALPFITDEFQISaHTQEWVVSSMMFGAAVGAVGSGWLSFKLGRKKSLMIG 89
Cdd:pfam06609  38 RSPRIIASFAAFSLNVCATYFVLQAS--ASALPNILQDIGQS-ENQGLFSTLWTMGQAVSILMMGRLTDRFGRRPFVIAT 114
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730   90 AILFVAGSLFSAAAPNVEVLIISRVLLGLAVGVASyTAPLYLSEIAPEKIR--GSMISMYQLMITIGiLGAYLSDTaFSY 167
Cdd:pfam06609 115 HIIGLVGAIVGCTANKFNTLLAAMTLLGVAAGPAG-ASPLFIGELMSNKTKflGLLIVSAPTIAMNG-AGPYFGQR-LAI 191

                  ....*...
gi 505384730  168 SGAWRWML 175
Cdd:pfam06609 192 QGNWRWIF 199
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
287-455 4.20e-05

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 45.68  E-value: 4.20e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 287 TTEQMWGTVIVGL-------TNVLATFIAIGLVDRWGRKPTLTLGFLVMAVGMGVLGTMmhmgiHSPtaqYFAVAMLLMF 359
Cdd:cd17329   27 HQQLGLSASIVGLvlalsavAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFA-----HSP---WLFAIALVLT 98
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 360 IIGFAMSAgPLIWVLCSEIQPLKGRDFGITCStatNWIAN--MIVGATFLTMLNTLGNANTFWVYAGLNLFFIVLTIWLV 437
Cdd:cd17329   99 GFGGGLFE-PASEAMIADVTTPENRTRAFSLL---YWAINlgVAIGPLLGGLLLLYSFRLLFLAAAVLFLLAALVLLFLL 174
                        170
                 ....*....|....*...
gi 505384730 438 PETKHVSLEHIERNLMKG 455
Cdd:cd17329  175 PETRPKRRAAEKTEILRG 192
MFS_TRI12_like cd06179
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ...
255-454 9.57e-05

Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340868 [Multi-domain]  Cd Length: 518  Bit Score: 44.92  E-value: 9.57e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 255 LGVLLQIMQQFTGMNVIMYYAPKIFELAGytNTTEQMWGTVIVGLTNVLATFIAIGLVDRWGRKPTLTLGFLVMAVGMgv 334
Cdd:cd06179    1 AALCLAYFAQLFGVTLPAAVLPFIVADLG--PSSNSTWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGS-- 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 335 lgtmmhmgIHSPTAQYFAVAMLLMFIIGFAMSAGPLIWVLCSEIQPLKGRDFGITCSTATNWIANMI--VGATFLTMLNT 412
Cdd:cd06179   77 --------IVAGTAKSVNMLIGGQALIGIGAGTQGLGAAVASELVPNKYRGLVQGVVNLVASPGSALgpLIAGALVEANA 148
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 505384730 413 LGNANTFWVYAGLNLF-FIVLTIWLVPETKHVSLEHIERNLMK 454
Cdd:cd06179  149 AGWRWIFYINAIFNALaLILLFFFYHPPPRPQLHGSSTRQKLK 191
MFS_SLC22A1_2_3 cd17379
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, ...
60-174 1.01e-04

Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, and 3) of the Major Facilitator Superfamily of transporters; This sufamily includes solute carrier family 22 member 1 (SLC22A1, also called organic cation transporter 1 or OCT1), SLC22A2 (or OCT2), SLC22A3 (or OCT3), and similar proteins. OCT1-3 have similar basic functional properties: they are able to translocate a variety of structurally different organic cations in both directions across the plasma membrane; to translocate organic cations independently from sodium, chloride or proton gradients; and to function as electrogenic uniporters for cations or as electroneutral cation exchangers. They show overlapping but distinct substrate and inhibitor specificities, and different tissue expression pattern. In humans, OCT1 is strongly expressed in the liver, OCT2 is highly expressed in the kidney where it is localized at the basolateral membrane of renal proximal tubules, and OCT3 is most strongly expressed in skeletal muscle. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. The SLC22A1-3 subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340937 [Multi-domain]  Cd Length: 340  Bit Score: 44.26  E-value: 1.01e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  60 SSMMFGAAVGAVGSGWLSFKLGRKKSLMIGAILFVAGSLFSAAAPNVEVLIISRVLLGLAVGVASYTAPLYLSEIAPEKI 139
Cdd:cd17379   40 SSLNLGFLIGSIVIGYLADRFGRKVCFLISILGNGVSGVLMAFSPNYPWFLIFRFLQGLFGKGGWMTGYVLVTEFVGSKY 119
                         90       100       110
                 ....*....|....*....|....*....|....*
gi 505384730 140 RGSMISMYQLMITIGILgaYLSDTAFsYSGAWRWM 174
Cdd:cd17379  120 RRTVGIVYQMFFTLGLL--ILPGIAY-FIPHWRWL 151
PRK11043 PRK11043
Bcr/CflA family multidrug efflux MFS transporter;
12-124 1.39e-04

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182924 [Multi-domain]  Cd Length: 401  Bit Score: 44.11  E-value: 1.39e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  12 NKAMTFFVCFLAALAGLLFgLDIGVIAGALPFITDEFQISAHTQEWVVSSMMFGAAVGAVGSGWLSFKLGRKKSLMIGAI 91
Cdd:PRK11043   1 MQPSKGFLVYLAGLSMLGF-LATDMYLPAFKAIQADLQTSASAVSASLSLFLAGFALGQLLWGPLSDRYGRKPVLLAGLS 79
                         90       100       110
                 ....*....|....*....|....*....|...
gi 505384730  92 LFVAGSLFSAAAPNVEVLIISRVLlgLAVGVAS 124
Cdd:PRK11043  80 LFALGSLGMLWVESAAQLLVLRFV--QAVGVCS 110
MFS_YajR_like cd17472
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ...
74-117 1.49e-04

Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341025 [Multi-domain]  Cd Length: 371  Bit Score: 43.74  E-value: 1.49e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 505384730  74 GWLSFKLGRKKSLMIGAILFVAGSLFSAAAPNVEVLIISRVLLG 117
Cdd:cd17472   53 GLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQG 96
PRK10406 PRK10406
alpha-ketoglutarate transporter; Provisional
74-173 1.80e-04

alpha-ketoglutarate transporter; Provisional


Pssm-ID: 182433 [Multi-domain]  Cd Length: 432  Bit Score: 43.64  E-value: 1.80e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  74 GWLSFKLGRKKSLMIGAILFVAGSLFSAAAPNVEV--------LIISRVLLGLAVGVASYTAPLYLSEIAPEKIRGSMIS 145
Cdd:PRK10406  84 GRIADKHGRKKSMLISVCMMCFGSLVIACLPGYETigtwapalLLLARLFQGLSVGGEYGTSATYMSEVAVEGRKGFYAS 163
                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 505384730 146 mYQLMITIG----------ILGAYLSDTAFSysgAWRW 173
Cdd:PRK10406 164 -FQYVTLIGgqllallvvvVLQQTLEDAELR---EWGW 197
MFS_Amf1_MDR_like cd17476
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ...
21-174 3.35e-04

Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341029 [Multi-domain]  Cd Length: 362  Bit Score: 42.63  E-value: 3.35e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  21 FLAALAGLLFGLDIGVIAGALPFITDEFQISAHTQEWVVSSmmFGAAVGA--VGSGWLSFKLGRKKSLMIGAILFVAGSL 98
Cdd:cd17476    1 ATISGAQLLNQAGLGSVIVILPIIGDSFGTSPNQLSWLAAS--YSLTVGTfiLIFGRLGDIYGHKKMFVIGSFWFAIWSL 78
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 505384730  99 FSAAAPNVEVLIISRVLLGLAVGVASYTAPLYLSEIAPEKIRGSMI-SMYQLMITIG-ILGAYLSDTAFSYSGaWRWM 174
Cdd:cd17476   79 IAGFSPNFIFFIICRALQGLGPAFLLPNAMALLGRTYPPGPRKNIVfSLFGATAPLGfALGGVFGGLFAQLAW-WPWI 155
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
62-160 3.39e-04

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 42.92  E-value: 3.39e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  62 MMFGAAVGAVGSGWLSFKLGRKKSLMIGAILFVAGSLFSAAAPNVEVLIISRVLLGLAVGVASYTAPLYLSEIAPEKIRG 141
Cdd:cd17370  243 FNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRG 322
                         90
                 ....*....|....*....
gi 505384730 142 SMISMYQLMITIGILGAYL 160
Cdd:cd17370  323 TAYGLFNTVVGIGWLLASL 341
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
19-171 5.04e-04

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 42.03  E-value: 5.04e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  19 VCFLAALAGLLFGLDIGVIAGALPFITDEFQISAHTQEWVVSSMMFGAAVGAVGSGWLS-FKLGRKKSLMIGAILFVAGS 97
Cdd:cd06174  205 LWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSdRLIGRKPLLLIGLLLMALGL 284
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 505384730  98 LFSAAAPNVEVLIISRVLLGLAVGVASYTAPLYLSEIAPEKIRGSMISMYQLMITIG-----ILGAYLSDTAFSYSGAW 171
Cdd:cd06174  285 ALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGgaigpLLAGFLLAATFGLTGAF 363
BtlA COG2270
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ...
35-150 7.59e-04

MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];


Pssm-ID: 441871 [Multi-domain]  Cd Length: 424  Bit Score: 41.68  E-value: 7.59e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  35 GVIAGALPFITDEFQISAHTQEWVVSSMMFGAAVGAVGSGWLSFKLGRKKSLMIGAILFVAGSLFSAAAPNVEVLIISRV 114
Cdd:COG2270  256 TVIAFAGIYAAGVLGFSTTELIVFGLLVQIVAALGALLFGRLDDRIGPKRVILVSLVIWIVVCLAAYFLTTALAFWILGL 335
                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 505384730 115 LLGLAVG---VASYTaplYLSEIAPEKIRGSMISMYQLM 150
Cdd:COG2270  336 LIGLVMGgiqALSRS---LLARLIPPGREAEFFGLYALS 371
MFS_YcxA_like cd17355
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ...
22-378 9.13e-04

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340913 [Multi-domain]  Cd Length: 386  Bit Score: 41.49  E-value: 9.13e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  22 LAALAGLLFGLDIGVIAGALPF---ITDEFQISAHTQEWVVSSMMFGAAVGAVGSGWLSFKLGRKKSLMIGAILFVAGSL 98
Cdd:cd17355    4 VLAVTFLILILSWGIRYYFGVFiipIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLV 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  99 FSAAAPNVEVLIISRVLL-GLAVGVASYTAPLYLSEIAPEKIRGsmismyqLMITIGILGAYLSDTAFSYSGA------- 170
Cdd:cd17355   84 LLALATSLWQLYLLWGLLgGGGAGTLAAVAFATVAAWWFERRRG-------LALGILTAGGGLGSLVFLPLGAalieafg 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 171 WRWMLGVIIIPAILLLIGVFFLPDSPRWFAAKRRFHDAERVLLRLRDTSAeakneleeireslkvkqsgwalfkensnFR 250
Cdd:cd17355  157 WRTALLVLALLALLVLVPVLLLLRRRPADLALRAYDDASPASPGSTLKEA----------------------------LR 208
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 251 RAVFlgVLLQIMQQFTG--MNVIMYYAPKIFELAGYTnTTEQMWGTVIVGLTNVLATFIAIGLVDRWGRKPTLTLGFLVM 328
Cdd:cd17355  209 SASF--WLLALAFFLCGfaVVGLIVHLVPYLADRGIS-PAAAAVALALIGLFNIVGRLLSGWLGDRYSPRRLLAASYALR 285
                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|
gi 505384730 329 AVGMGVLGtmmhmgihSPTAQYFAVAMLLMFIIGFAMSAGPLIWVLCSEI 378
Cdd:cd17355  286 ALGLALLL--------LLPFPPLALLLFAALFGLGWGATVPLTAALAARY 327
MFS_SLC22A15 cd17377
Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; ...
58-133 1.15e-03

Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 15 (SLC22A15) is also called fly-like putative transporter 1 (FLIPT1). It is expressed at the highest levels in the kidney and brain. It is a member of the SLC22 family of transporters, which includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A15 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340935 [Multi-domain]  Cd Length: 353  Bit Score: 40.92  E-value: 1.15e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 505384730  58 VVSSMMF-GAAVGAVGSGWLSFKLGRKKSLMIGAILFVAGSLFSAAAPNVEVLIISRVLLGLAVGVASYTAPLYLSE 133
Cdd:cd17377   43 LASSFFFaGVLIGVVSFGQLSDRFGRKPVYLTGLALDILFAYFNALAPSYEFFAVSRFLVGVMNGGMSLVAFVLLNE 119
MFS_MelB_like cd17332
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ...
24-135 1.23e-03

Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340890 [Multi-domain]  Cd Length: 424  Bit Score: 41.05  E-value: 1.23e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  24 ALAGLLFGLDIGVIAGALPFITDEFQISAHTQEWVVSSMMFGAAVGAVGSGWLSFKLGRKKSLMIGAILFVAGSL--FSA 101
Cdd:cd17332  227 LLAYLLYFLAFNIVNTVLVYYFKYVLGGRAELVLLLLLILSGALLALLPWPPLKKRFGKKKAFFIGLLLAILGLLllFFL 306
                         90       100       110
                 ....*....|....*....|....*....|....
gi 505384730 102 AAPNVEVLIISRVLLGLAVGVASYTAPLYLSEIA 135
Cdd:cd17332  307 PPGNLVLILVLAVLAGIGYGGANLLPWAMLADVI 340
PRK10504 PRK10504
putative transporter; Provisional
32-118 1.65e-03

putative transporter; Provisional


Pssm-ID: 182502 [Multi-domain]  Cd Length: 471  Bit Score: 40.87  E-value: 1.65e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  32 LDIGVIAGALPFITDEFQISAHTQEWVVSSMMFGAAVGAVGSGWLSFKLGRKKSLMIGAILFVAGSLFSAAAPNVEVLII 111
Cdd:PRK10504  24 LDTTIVNTALPSMAQSLGESPLHMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFTAIVLFTLGSLFCALSGTLNELLL 103

                 ....*..
gi 505384730 112 SRVLLGL 118
Cdd:PRK10504 104 ARVLQGV 110
PRK10473 PRK10473
MdtL family multidrug efflux MFS transporter;
15-146 1.74e-03

MdtL family multidrug efflux MFS transporter;


Pssm-ID: 182486 [Multi-domain]  Cd Length: 392  Bit Score: 40.39  E-value: 1.74e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  15 MTFFVCFLAALAgLLFGLDIGVIAGALPFITDEFQISAHTQEWVVSSMMFGAAVGAVGSGWLSFKLGRKKSLMIGAILFV 94
Cdd:PRK10473   1 MSRFLLCSFALV-LLYPAGIDMYLVGLPRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKIADRSGRKPVAIPGAALFI 79
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 505384730  95 AGSLFSAAAPNVEVLIISRVLLGLAVGVASYTAPLYLSEIAPEKIRGSMISM 146
Cdd:PRK10473  80 IASLLCSLAETSSLFLAGRFLQGIGAGCCYVVAFAILRDTLDDRRRAKVLSL 131
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
35-380 1.78e-03

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 40.62  E-value: 1.78e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  35 GVIAGALPFITDEFQISAHTQEWVVSSMMFGAAVGAVGSGWLSFKLGRKKSLMIGaILFVAGSLFSAA-APNVEVLIISR 113
Cdd:cd17478   13 GFLPALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLG-PLLTGLGLSLLGfAPNYWLLLLLV 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 114 VLLGLAVGVASYTAPLYLSEIAPEKiRGSMISMYQLMITIGI-LGAYLSDTAFsysgAWRWMLGVIIIPAILLLIGVFFL 192
Cdd:cd17478   92 ALAGIGSAAFHPEGARLASQAAGGR-RGLAMSIFSVGGNLGFaLGPLIAAALV----ALFGGLGLLILLIIPGLAVALLL 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 193 pdsprwfaakrrfhdaeRVLLRLRDTSAEAKNELEEIRESLKVKQSGWALFKENSNFRRAVFLGVLLqimqqftgmnvim 272
Cdd:cd17478  167 -----------------LRLRPLKKPEAKKAAAKSSARSTLKGVWRALLLLLIIVFLRSWVLSSLTT------------- 216
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 273 yYAPKIFELAGYTNTTEQMWGTVIVgLTNVLATFIAIGLVDRWGRKPTLTLGFLVMAVGMGVLgtmmhmgIHSPTaqyfA 352
Cdd:cd17478  217 -FLPFYLVQRGYSLVFAGLLLSLFL-FAGAIGTLIGGPLSDRFGRRRVIIASLLLAAPFLLLF-------LLTPG----I 283
                        330       340
                 ....*....|....*....|....*....
gi 505384730 353 VAMLLMFIIGFA-MSAGPLIWVLCSEIQP 380
Cdd:cd17478  284 WSYILLVLAGFLlFASFPVTVVLAQELLP 312
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
58-160 2.21e-03

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 40.23  E-value: 2.21e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  58 VVSSMMFGAAVGAVGSGWLSFKLGRKKSLMIGAILFVAGSLFSAAAPNVeVLIISRVLLGLAVGVASYTAPLYLSEIAPE 137
Cdd:cd17478  235 LLSLFLFAGAIGTLIGGPLSDRFGRRRVIIASLLLAAPFLLLFLLTPGI-WSYILLVLAGFLLFASFPVTVVLAQELLPG 313
                         90       100
                 ....*....|....*....|....*
gi 505384730 138 KIrgSMIS--MYQLMITIGILGAYL 160
Cdd:cd17478  314 NV--GLASglMMGLSFGLGGIGAPV 336
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
14-171 3.55e-03

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 39.48  E-value: 3.55e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  14 AMTFFVCFLAALAGLLFGL-------------------DIGVIAGALPFITDEFQISAHTQEWVVSSM-MFGAAVGAVGS 73
Cdd:cd17330  152 ALPFLVAAALALLNLVLVLfflpplrrlllvyflialaFAGLESVFSLFLKDRFGFSPSQIGLLLALVgIAGILAQLLLI 231
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  74 GWLSFKLGRKKSLMIGAILFVAGSLFSAAAPNVEVLIISRVLLGLAVGVASYTAPLYLSEIAPEKIRGSMISMYQLMITI 153
Cdd:cd17330  232 PRLAKRLGERKLLRLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSL 311
                        170
                 ....*....|....*....
gi 505384730 154 G-ILGAYLSDTAFSYSGAW 171
Cdd:cd17330  312 ArIIGPLLAGPLYSFLGPG 330
emrD PRK11652
multidrug transporter EmrD;
40-123 4.14e-03

multidrug transporter EmrD;


Pssm-ID: 183259 [Multi-domain]  Cd Length: 394  Bit Score: 39.51  E-value: 4.14e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  40 ALPFITDEFQISAHTQEWVVSSMMFGAAVGAVGSGWLSFKLGRKKSLMIGAILFVAGSLFSAAAPNVEVLIISRVLLGLA 119
Cdd:PRK11652  30 AIADMARDLNVREGAVQAVMAAYLLTYGLSQLFYGPLSDRVGRRPVILVGMSIFILGTLVALFAHSLTVLIAASAIQGLG 109

                 ....
gi 505384730 120 VGVA 123
Cdd:PRK11652 110 TGVG 113
MFS_ShiA_like cd17369
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ...
58-177 4.36e-03

Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340927 [Multi-domain]  Cd Length: 408  Bit Score: 39.43  E-value: 4.36e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  58 VVSSMMFGAAVGAVG---SGWLSFKLGRKKSLMIGAILFV--AGSLFSAAAPNVEVLIISRVLLGLAVGVASYTAPL--Y 130
Cdd:cd17369  266 VLLAVLIASVVAAITiplFGWLSDRVGRRPVYLAGALLAAlfAFPFFWLLDTGSTWLIVLAAVVVLGVLHGMMYGPQaaF 345
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 505384730 131 LSEIAPEKIRGSMISM-YQLmitIGILGA----YLSDTAFSYSGAWRWMLGV 177
Cdd:cd17369  346 LAELFPTRVRYTGASLgYQL---GAILGGgfapLIATALVAATGSWWPVALY 394
MFS_SLC22A7_OAT2 cd17447
Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major ...
65-175 4.62e-03

Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 7 (SLC22A7), also called organic anion transporter 2 (OAT2) mediates sodium-independent transport of a variety of organic anions including prostaglandin E2, prostaglandin F2, tetracycline, bumetanide, estrone sulfate, glutarate, dehydroepiandrosterone sulfate, allopurinol, 5-fluorouracil, paclitaxel, L-ascorbic acid, salicylate, ethotrexate, and alpha-ketoglutarate. It also plays a role in renal uric acid uptake from blood as a first step of tubular secretion. OAT2 belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS)of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341005 [Multi-domain]  Cd Length: 341  Bit Score: 38.94  E-value: 4.62e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  65 GAAVGAVGSGWLSFKLGRKKSLMIGAILFVAGSLFSAAAPNVEVLIISRVLLGLAV-GVASYTAPLYLS--EIAPEKIRG 141
Cdd:cd17447   47 GVTMGAVAFGYLSDRFGRKRMLLVAYVLSLVFGLASAFSVSYVMFAITRTLTGFALtGFSIISMVLCVEwvDIEHRTVAG 126
                         90       100       110
                 ....*....|....*....|....*....|....
gi 505384730 142 SMISmyqLMITIGILGayLSDTAFsYSGAWRWML 175
Cdd:cd17447  127 VLIS---LFWTVGNML--LALVAY-LIRDWRWLI 154
MFS_OAT cd17374
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ...
60-174 5.68e-03

Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340932 [Multi-domain]  Cd Length: 341  Bit Score: 38.81  E-value: 5.68e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  60 SSMMFGAAVGAVGSGWLSFKLGRKKSLMIGAILFVAGSLFSAAAPNVEVLIISRVLLGLAV-GVASYTAPLYLSEIAPEK 138
Cdd:cd17374   42 SIFMAGLLVGALIFGHLSDRFGRKFILLLSLLQLAIFGTCAAFAPTFPVYCVLRFLAGFAVsGISINTLILGTEWTTPRH 121
                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 505384730 139 iRGSMISMYQLMITIGilGAYLSDTAFSYSGaWRWM 174
Cdd:cd17374  122 -RALAITLTSCFFSIG--QMLLAGLAYAIRD-WRLL 153
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
314-459 6.96e-03

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 38.73  E-value: 6.96e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 314 RWG-RKPTLTLGFLVMAVGMGVLGTMMHMGIHSPTAQYFAVAMLLMFIIGFAMSAgplIWVLCSEI-QPLKGRDFGITCS 391
Cdd:COG2211   76 RWGrRRPWILIGAIPLALSFVLLFTAPDLSPTGKLIYALVTYLLLGLAYTLVNIP---YSALGAELtPDYEERTRLSSWR 152
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 505384730 392 TATNWIANMIVGATFLTMLNTLGNAN------TFWVYAGLNLFFIVLTIWLVPETKHVSLEHIE-----RNLMKGRPLR 459
Cdd:COG2211  153 FAFAGLGGLLASVLPPPLVAAFGGDAalgyrlTALIFAVLGLLAFLLTFFGTKERPVPEEEKVSlkeslKALLKNRPFL 231
MFS_MT3072_like cd17475
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ...
21-123 7.16e-03

Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341028 [Multi-domain]  Cd Length: 378  Bit Score: 38.37  E-value: 7.16e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  21 FLAALAGLLFGLDIGVIAgalPFITDEFQISAHTQEWVVSSMMFGAAVGAVGSGWLSFKLGRKKSLMIGAILFVAGSLFS 100
Cdd:cd17475    2 TLAQAAASLVAQGIPALA---PFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLM 78
                         90       100
                 ....*....|....*....|...
gi 505384730 101 AAAPNVEVLIISRVLLGLAVGVA 123
Cdd:cd17475   79 ALVGSYPVLLVLLFLVGAGYGSV 101
MFS_YxlH_like cd17490
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ...
21-156 7.36e-03

Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341043 [Multi-domain]  Cd Length: 371  Bit Score: 38.36  E-value: 7.36e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  21 FLAALAGLLFGLDIGVIAGALPFITDEFQISAHTQEWVVSSMMFGAAVGAVGSGWLSF-KLGRKKSLMIGAILFVAGSLF 99
Cdd:cd17490  198 FFSLLAILQQMITFSTTFGFTPLIAKQLGASSFQLGLLSIIYLLPNALASLLSGTLFYkKLGERNTIIIGFLLLGAYCFL 277
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730 100 SAAAPNVEVLIISRVLLGLAVGVASytaPLYLS---EIAPEKIRGSMISMYQLMITIGIL 156
Cdd:cd17490  278 IPFAPNLTLLYLLQALNGFGTGILF---PLLMSlsiEGVPAEQRSTAMGFFQAIYALGMF 334
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
21-177 9.02e-03

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 38.34  E-value: 9.02e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  21 FLAALAGLLFGLDIGVIAGALPFITDEFQISAhtqeWVVSSMMFGAAVGAVG--SGWLSFKLGRKKSLMIGAILFVAGSL 98
Cdd:cd17489  197 LPPALILFLASIAYGAISTFLPLYAAERGISN----AGLFFTVYAIALLLSRpfSGKLSDRKGPKTVIIPGLLLLALGLL 272
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384730  99 FSAAAPNVEVLIISRVLLGLAVGVASYTAPLYLSEIAPEKIRGSMISMYQLMITIGI-LGAYLSD---TAFSYSGAWRWM 174
Cdd:cd17489  273 LLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIgLGGLLLGlvaELFGYRAMFLLA 352

                 ...
gi 505384730 175 LGV 177
Cdd:cd17489  353 AVV 355
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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